MCID: DNT012
MIFTS: 52

Dental Caries

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Dental Caries

MalaCards integrated aliases for Dental Caries:

Name: Dental Caries 12 75 55 44 15 17 72 33
Dental Caries Extending into Pulp 12
Dental Caries of Smooth Surface 12
Dental Caries Pit and Fissure 12
Smooth Surface Dental Caries 17

Classifications:



External Ids:

Disease Ontology 12 DOID:216
MeSH 44 D003731
NCIt 50 C52593
SNOMED-CT 68 80967001
ICD10 33 K02 K02.6 K02.9
UMLS 72 C0011334 C1456145

Summaries for Dental Caries

MalaCards based summary : Dental Caries, also known as dental caries extending into pulp, is related to root caries and dental fluorosis, and has symptoms including halitosis and snoring. An important gene associated with Dental Caries is DSPP (Dentin Sialophosphoprotein), and among its related pathways/superpathways is Salivary secretion. The drugs Midazolam and Aspirin have been mentioned in the context of this disorder. Affiliated tissues include testes, salivary gland and bone, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 75 Tooth decay, also known as dental caries or cavities, is a breakdown of teeth due to acids made by... more...

Related Diseases for Dental Caries

Diseases related to Dental Caries via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 279)
# Related Disease Score Top Affiliating Genes
1 root caries 33.6 LTF DSPP CD79A
2 dental fluorosis 31.8 DSPP AMELX
3 aplasia of lacrimal and salivary glands 31.6 LTF LPO FGF10 DSPP
4 dental pulp necrosis 30.7 DSPP AMELX
5 dentin caries 12.2
6 enamel caries 11.9
7 tricho-dento-osseous syndrome 1 11.5
8 periapical periodontitis 11.4
9 flynn-aird syndrome 11.3
10 cockayne syndrome a 11.3
11 cutis laxa, autosomal recessive, type iia 11.3
12 insensitivity to pain, congenital, with anhidrosis 11.3
13 osteopetrosis, autosomal recessive 1 11.3
14 timothy syndrome 11.3
15 cockayne syndrome 11.3
16 periapical granuloma 11.3
17 benjamin syndrome 11.3
18 dominant dystrophic epidermolysis bullosa 11.3
19 recessive dystrophic epidermolysis bullosa-generalized other 11.3
20 odontoclasia 11.0
21 gingivitis 10.9
22 periodontitis 10.8
23 body mass index quantitative trait locus 1 10.7
24 down syndrome 10.6
25 body mass index quantitative trait locus 11 10.6
26 body mass index quantitative trait locus 9 10.6
27 body mass index quantitative trait locus 8 10.6
28 body mass index quantitative trait locus 4 10.6
29 body mass index quantitative trait locus 10 10.6
30 body mass index quantitative trait locus 7 10.6
31 body mass index quantitative trait locus 12 10.6
32 body mass index quantitative trait locus 14 10.6
33 body mass index quantitative trait locus 18 10.6
34 body mass index quantitative trait locus 19 10.6
35 body mass index quantitative trait locus 20 10.6
36 cerebral palsy 10.5
37 chronic ethmoiditis 10.5 MUC7 MUC5B
38 amelogenesis imperfecta, type iiia 10.5 ENAM AMELX
39 pulpitis 10.5
40 cleft lip 10.5
41 parotitis 10.4 LTF CD79A
42 hair whorl 10.4
43 rapidly involuting congenital hemangioma 10.4
44 dental pulp calcification 10.4 ENAM DSPP
45 amelogenesis imperfecta, hypoplastic/hypomaturation, x-linked 2 10.4 TUFT1 AMELX
46 tooth erosion 10.4 TUFT1 DSPP
47 iron metabolism disease 10.4
48 47,xyy 10.4
49 cleft lip/palate 10.4
50 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.4

Comorbidity relations with Dental Caries via Phenotypic Disease Network (PDN): (show all 12)


Acute Apical Periodontitis Acute Cystitis
Acute Pericementitis Alzheimer Disease
Aortic Valve Disease 1 Deficiency Anemia
Familial Atrial Fibrillation Gingivitis
Heart Disease Periodontitis, Chronic
Periodontosis Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Dental Caries:



Diseases related to Dental Caries

Symptoms & Phenotypes for Dental Caries

UMLS symptoms related to Dental Caries:


halitosis, snoring

GenomeRNAi Phenotypes related to Dental Caries according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00381-A-1 9.4 CD79A LTF TAS1R2 TUFT1
2 Decreased viability GR00381-A-3 9.4 CD79A LTF TAS1R2 TUFT1
3 Decreased viability GR00402-S-2 9.4 CD79A LTF TAS1R2 TUFT1

Drugs & Therapeutics for Dental Caries

Drugs for Dental Caries (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 272)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
2
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
3
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
4
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
5
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
6
Imidacloprid Vet_approved Phase 4 105827-78-9 86418
7 Caseins Phase 4
8 Chelating Agents Phase 4
9 Bifidobacterium Phase 4
10 Acidophilus Phase 4
11 Anti-Inflammatory Agents Phase 4
12 Tranquilizing Agents Phase 4
13 Psychotropic Drugs Phase 4
14 Gastrointestinal Agents Phase 4
15 Cathartics Phase 4
16 Laxatives Phase 4
17 Anti-Anxiety Agents Phase 4
18 GABA Agents Phase 4
19 Adjuvants, Anesthesia Phase 4
20 GABA Modulators Phase 4
21 Cyclooxygenase Inhibitors Phase 4
22 Fibrinolytic Agents Phase 4
23 Anti-Inflammatory Agents, Non-Steroidal Phase 4
24 Antipyretics Phase 4
25 Platelet Aggregation Inhibitors Phase 4
26 Antirheumatic Agents Phase 4
27 Central Nervous System Depressants Phase 4
28 Anesthetics Phase 4
29 Neurotransmitter Agents Phase 4
30 Adrenergic Agonists Phase 4
31 Adrenergic Agents Phase 4
32 Peripheral Nervous System Agents Phase 4
33 Anesthetics, General Phase 4
34 Anesthetics, Intravenous Phase 4
35 Analgesics Phase 4
36 Hypnotics and Sedatives Phase 4
37 Excitatory Amino Acid Antagonists Phase 4
38 Anesthetics, Dissociative Phase 4
39 Excitatory Amino Acids Phase 4
40 Analgesics, Non-Narcotic Phase 4
41 Adrenergic alpha-Agonists Phase 4
42 Adrenergic alpha-2 Receptor Agonists Phase 4
43 Cariostatic Agents Phase 4
44 Fluorides Phase 4
45 Protective Agents Phase 4
46 Calcium, Dietary Phase 4
47 Hormones Phase 4
48 Bone Density Conservation Agents Phase 4
49 Cinnamon Approved Phase 3
50
Salicylic acid Approved, Investigational, Vet_approved Phase 3 69-72-7 338

Interventional clinical trials:

(show top 50) (show all 652)
# Name Status NCT ID Phase Drugs
1 Dental Caries Management by Risk Assessment: Identification and Treatment of Risk Factors Among Israeli Defence Force (IDF) Personnel Unknown status NCT01142440 Phase 4
2 Phase 4 Study Prevention of Incipient Carious Lesions (White Spot Lesions) in Patients With Fixed Orthodontic Appliances Following the Application of Elmex Gel Unknown status NCT00268138 Phase 4 elmex gel
3 Consumption Effect of Probiotic Products on Salivary Cariogenic Bacterial Counts in Preschool Children. Unknown status NCT02692625 Phase 4
4 Anticaries Effect of Probiotic Lactobacillus Brevis CD2 (Lb CD2). A Randomized Double Blind Interventional Study. Unknown status NCT01778699 Phase 4
5 Prevention of Dental Caries Lesions With Fluoride Varnish in Erupting First Permanent Molars Completed NCT02592278 Phase 4 Fluoride Varnish;Control Group
6 Comparison of Enamel Remineralization Potential of Dentifrices Incorporating Different Fluoride Salts Using an in Situ Caries Model Completed NCT01128946 Phase 4 NaF;SnF;NaMFP
7 The Effectiveness of Sealants in Prevention of Occlusal Caries on Primary Molars Completed NCT01438866 Phase 4
8 Evaluation of Resin Modified Glass Ionomer Liner (Vitrebond™) Versus Calcium Hydroxide as Indirect Pulp Treatment Material Used in Deep Carious Lesions in Primary Molars: A Randomized Clinical Trial Completed NCT03770871 Phase 4 Dycal (Indirect pulp treatment);Vitrebond (Indirect pulp treatment)
9 Fuji Type VII Sealants Versus Resin Based Sealants. A Clinical Trial Completed NCT02795728 Phase 4
10 A Study to Measure the Effect of Dentifrice Usage Regime on Delivery and Efficacy of Fluoride Using an In Situ Caries Model Completed NCT01563172 Phase 4 Sodium fluoride / silica and carbopol, 0.5g;Sodium fluoride / silica and carbopol, 1.5g;Sodium fluoride / silica and carbopol, 1.5g
11 A 2-year Clinical Study on Postoperative Pulpal Complications Arising From the Absence of a Glass-ionomer Lining in Deep Occlusal Resin Composite Restorations Completed NCT01567514 Phase 4
12 Impact of Maternal Xylitol Consumption on Mutans Sterptococci ,Plaque and Caries Levels in Children Completed NCT02036151 Phase 4 xylitol;fluoride varnish application
13 Therapeutic Effect of Two Fluoride Varnishes on White Spot Lesions: a Clinical Study Completed NCT00723515 Phase 4 sodium fluoride;sodium fluoride calcium fluoride
14 Effect of the Amount of Fluoride Toothpaste on Fluoride Availability in the Oral Fluids in Children Completed NCT03455621 Phase 4
15 Evaluation of the Impact of Fluoride Vanish Application in Dental Prevention Among Institutionalised Elderly People Completed NCT01038817 Phase 4 Duraphat
16 Randomized Controlled Trial of Oral Sedatives for Moderate Sedation in Young Children Completed NCT00902395 Phase 4 Midazolam;Midazolam, ketamine
17 A Randomized Clinical Trial on Preventive and Therapeutic Proximal Sealants Completed NCT02338180 Phase 4
18 White Spot Lesion Development in Post-orthodontic Patients Following Weekly Application of a 1.25% Fluoride Gel Compared to Placebo Over 6 Months Completed NCT01329731 Phase 4 elmex® gelée;negative control (placebo)
19 Bifidobacterium Lactis BB12 and Xylitol Delivered With a Novel Slow-release Pacifier Completed NCT00638677 Phase 4
20 Caries-preventive Effectiveness of a Dentifrice Containing 5.000 Ppm Fluoride - a Randomized Controlled Trial in Adolescents With Fixed Orthodontic Appliances Completed NCT01768390 Phase 4
21 Economic Evaluation of ART Sealant in Preventing Pit and Fissure Caries in Permanent First Molars in an Asia Population Completed NCT03034837 Phase 4 resin sealant;ART sealant
22 Comparison Of The Caries-Protective Effect Of Fluoride Varnish (Duraphat®) With Treatment As Usual In Nursery School Attendees Receiving Preventive Oral Health Support Through The Childsmile Oral Health Improvement Programme: An RCT Completed NCT01674933 Phase 4 Duraphat® Fluoride Varnish
23 The Effect of Silver Diamine Fluoride (SDF) on Bacteria Involved in Root or Cervical Carious Lesions Using HOMINGS Technology. A Clinical Study Completed NCT02953886 Phase 4
24 Partial Pulpotomy Treatment Of Immature Permanent Molars: A Randomized Clinical Trial Completed NCT03426046 Phase 4 Pulp Capping Agents
25 Efficacy, Safety and Cost-effectiveness of Intranasal Sedation With Ketamine and Midazolam in Pediatric Dentistry: a Randomized Clinical Trial Completed NCT02447289 Phase 4 Intranasal ketamine;Oral ketamine;Intranasal midazolam;Oral midazolam
26 Comparison of the Effect of Fluoride Remineralizer Gel and Foam: a Randomized Clinical Trial Completed NCT02490592 Phase 4
27 Comparison of Topical Analgesic With Saline Rinses in Post Extraction Healing Among Hypertensive and Non-hypertensive Subjects Completed NCT02921165 Phase 4 analgesic mouth rinses (dissolved Aspirin);Normal saline rinses.
28 Oral Fluoride Bioavailability by the Consumption of Meals Prepared With Fluoridated Water or Salt Completed NCT02776280 Phase 4
29 Effects of Two Sugar Substituted Chewing Gums Plus Tooth Brushing on Different Caries and Gingivitis Related Variables: a Double Blind, Randomized Controlled Clinical Trial Completed NCT01578603 Phase 4
30 MI Varnish and MI Paste Plus in a Caries Prevention and Remineralization Study Completed NCT02424097 Phase 4 CPP-ACP 5% sodium fluoride varnish & 900ppm fluoride paste;1,100pm F-toothpaste and 0.5%NaF rinse
31 Interaction Chlorhexidine-fluoride - a 4-day and 6-week Randomised Clinical Mouthrinse Study Completed NCT02935322 Phase 4 0.12 % chlorhexidine + 0.2 % NaF mouthrinse;0.2 % NaF mouthrinse;0.12% chlorhexidine
32 Dental Fluorosis Risk by the Use of Acidulated Fluoride Dentifrice: Clinical Trial - Epidemiological Study With Children Residing in an área Without Public Water Fluoridation Completed NCT03761485 Phase 4
33 The Use of MI Varnish for the Prevention and Reduction of White Spot Lesions in Orthodontic Treatment Completed NCT03446690 Phase 4 MI Varnish
34 BiodentineTM Versus Formocresol Pulpotomy Technique in Primary Molars: A 12-Month Randomized Controlled Clinical Trial Completed NCT03779698 Phase 4 Formocresol
35 Effect of Probiotic on the Plaque pH. A Randomized Double Blind Interventional Study Completed NCT01601145 Phase 4
36 FISSURE-Project. Improved Dental Decay Management in Dental Service for Children: Fissure Sealants or Fluoride Varnish? Recruiting NCT03315312 Phase 4 Fluoride Varnishes;Fissure Sealants
37 Post-operative Pain After Silver Diamine Fluoride Application in Primary Molars With Deep Caries Versus Interim Restorative Therapy Recruiting NCT03563534 Phase 4 Silver Diamine Fluoride;Glass Ionomer
38 Clinical and Radiographic Evaluation of a New Bioactive Ionic Resin Material (ACTIVA™ BioACTIVE) Versus Compomer for Class II Restorations in Primary Molars: A Split Mouth Randomized Clinical Trial Recruiting NCT03516838 Phase 4 ACTIVA™ BioACTIVE;Compomer
39 Reminerlization Potential of Innovative Biomimetic Material Versus Casein Phosphopeptide-amorphous Calcium Phosphate in Caries White Spot Lesions "A Randomized Clinical Trial" Recruiting NCT03823612 Phase 4 Clinpro Tooth Creme;GC tooth mousse
40 Esthetic Effect of Casein Phosphopeptide-Amorphous Calcium Phosphate Varnish Versus Tricalcium Phosphate Varnish on Postorthodontic White Spot Lesions: A Randomized Pilot Study Recruiting NCT03217084 Phase 4 MI varnish GC;White varnish 3M
41 Clinical Efficacy of Giomer Versus Sodium Fluoride Varnish for Management of Hypersensitivity: Randomized Control Trail Recruiting NCT03818945 Phase 4 shofu PRG barrier coat;Sodium fluoride varnish
42 Intranasal Sedation With Dexmedetomidine and Ketamine in Pediatric Dentistry (NASO II): Randomized Clinical Trial Recruiting NCT03290625 Phase 4 Dexmedetomidine Hydrochloride;Ketamine Hydrochloride
43 The Effectiveness of MI and PreviDent Varnish on Non Cavitated Interproximal Lesions. Randomised Clinical Trial Active, not recruiting NCT03925740 Phase 4 MI Varnish;PreviDent Varnish;1.23% ACP fluoride
44 Discoloration of Carious Primary Teeth After Application of Silver Diamine Fluoride Versus Sodium Fluoride Varnish: A Randomized Clinical Trial Not yet recruiting NCT03557996 Phase 4 Silver Diamine Fluoride;Sodium Fluoride Varnish
45 Postoperative Pain After Application of Silver Diamine Fluoride Verses Sodium Fluoride Varnish in Treatment of Carious Primary Teeth (A Randomized Clinical Trial) Not yet recruiting NCT03554980 Phase 4 Silver Diamine Fluoride;Sodium Fluoride varnish
46 Clinical and Radiographic Evaluation of Light Cured Resin Modified Calcium Silicate Versus Light Cured Calcium Hydroxide in Indirect Pulp Treatment of Primary Molars Not yet recruiting NCT03791255 Phase 4 Calcium silicate liner;Calcium hydroxide liner
47 Comparison of Silver Modified and Conventional Atraumatic Restorative Treatment Modalities in Primary Molars in a Group of Egyptian School Children. A Randomized Controlled Trial Not yet recruiting NCT03881020 Phase 4 Silver diamine Fluoride 38%
48 The Effectiveness of Resin-Modified Glass Ionomer Varnish in Preventing White Spot Lesions During Fixed Appliance Orthodontic Therapy Withdrawn NCT03711097 Phase 4 Vanish XT Dental Varnish
49 Study on Children's Dental Caries Prevention and Mechanism Unknown status NCT02341352 Phase 3 fluoride varnish
50 Phase 3 Study of Using Combination of Bi Phasic Calcium Phosphate and Bu Phasic Calcium Sulphate During Extractions Unknown status NCT01503593 Phase 3

Search NIH Clinical Center for Dental Caries

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Alcloxa
aluminum chloride
Nicotine
Sodium fluoride
Sodium fluorophosphate
Stannous fluoride
Triclosan

Cochrane evidence based reviews: dental caries

Genetic Tests for Dental Caries

Anatomical Context for Dental Caries

MalaCards organs/tissues related to Dental Caries:

41
Testes, Salivary Gland, Bone, Heart, Colon, Breast, Thyroid

Publications for Dental Caries

Articles related to Dental Caries:

(show top 50) (show all 17223)
# Title Authors PMID Year
1
Analysis of the association between lactotransferrin (LTF) gene polymorphism and dental caries. 9 38
20485928 2010
2
Mucosal and systemic immunization with targeted fusion anti-caries DNA plasmid in young rats. 9 38
19428904 2009
3
[Oral health suggestion on dental caries, periodontal diseases, dentin hypersensitivity, and malocclusion]. 9 38
19575979 2009
4
[Relationship of concentration of lactoferrin and lysozyme in saliva and dental caries in primary dentition]. 9 38
19563039 2009
5
Assessment of the nanostructure of acid-base resistant zone by the application of all-in-one adhesive systems: Super dentin formation. 9 38
19581710 2009
6
Quantitative assessment of IgA levels in the unstimulated whole saliva of caries-free and caries-active children. 9 38
19008624 2008
7
Common dental infections in the primary care setting. 9 38
18386594 2008
8
Ammonium hexafluorosilicate elicits calcium phosphate precipitation and shows continuous dentin tubule occlusion. 9 38
17544103 2008
9
Composite restorations in the anterior region: clinical and aesthetic performances. 9 38
17970479 2007
10
Dentin in severe fluorosis: a quantitative histochemical study. 9 38
17720855 2007
11
Identification and subcellular localization of paracellin-1 (claudin-16) in human salivary glands. 9 38
17551748 2007
12
Effect of a papain-based gel for chemomechanical caries removal on dentin shear bond strength. 9 38
18477426 2007
13
A possible role of LIM mineralization protein 1 in tertiary dentinogenesis of dental caries treatment. 9 38
17374459 2007
14
Differential expression profiles of Streptococcus mutans ftf, gtf and vicR genes in the presence of dietary carbohydrates at early and late exponential growth phases. 9 38
16764842 2006
15
Criteria for a diagnosis of caries through the DIAGNOdent. 9 38
16503789 2006
16
Relationship between large tubules and dentin caries in human deciduous tooth. 9 38
16285599 2005
17
Matrix metalloproteinases (MMPs) in oral diseases. 9 38
15533204 2004
18
Correlation among mutans streptococci counts, dental caries, and IgA to Streptococcus mutans in saliva. 9 38
16089269 2004
19
Carbon dioxide laser in dental caries prevention. 9 38
15304298 2004
20
Both lactoferrin and iron influence aggregation and biofilm formation in Streptococcus mutans. 9 38
15222477 2004
21
Aluminum concentrations in human deciduous enamel and dentin related to dental caries. 9 38
15646261 2004
22
A historical glimpse of toothpick use: etiquette, oral and medical conditions. 9 38
12846259 2003
23
Microbiology and management of endodontic infections in children. 9 38
14604136 2003
24
Infectious complications of dental and periodontal diseases in the elderly population. 9 38
11941548 2002
25
Compositional and structural changes of human dentin following caries removal by Er,Cr:YSGG laser irradiation in primary teeth. 9 38
12175132 2002
26
Pulp-dentin biology in restorative dentistry. Part 4: Dental caries--characteristics of lesions and pulpal reactions. 9 38
11695140 2001
27
[Dental pain]. 9 38
11680189 2001
28
Presence or absence of tertiary dentinogenesis in relation to caries progression. 9 38
12640747 2001
29
A vaccine against dental caries: an overview. 9 38
11543691 2001
30
A case report: arresting dental caries. 9 38
11603306 2001
31
Hereditary and environmental dental findings in identification of human remains. 9 38
10946469 2000
32
In vitro dentinal surface reaction of 9.5% buffered hydrofluoric acid in repair of ceramic restorations: a scanning electron microscopic investigation. 9 38
10842137 2000
33
The relation between salivary IgA and caries in renal transplant patients. 9 38
10807716 2000
34
1H-NMR analysis of microbial-derived organic acids in primary root carious lesions and saliva. 9 38
10516616 1999
35
RVG-ui: a sensor to rival direct-exposure intra-oral x-ray film. 9 38
11351483 1999
36
Intranasal immunization against dental caries with a Streptococcus mutans-enriched fimbrial preparation. 9 38
10225844 1999
37
Hydrophobic interaction chromatography and capillary zone electrophoresis to explore the correlation between the isoenzymes of salivary alpha-amylase and dental caries. 9 38
10219681 1999
38
Occurrence and distribution of caries in 6-year-old children in Blekinge, Sweden. 9 38
10431342 1999
39
Can low accuracy disease risk predictor models improve health care using decision support systems? 9 38
9929285 1998
40
Phosphoprotein analysis of sequential extracts of human dentin and the determination of the subsequent remineralization potential of these dentin matrices. 9 38
9701661 1998
41
Immunoglobulin A reaction to oral streptococci in saliva of subjects with different combinations of caries and levels of mutans streptococci. 9 38
9467389 1997
42
Characterization of multiply phosphorylated peptides selectively precipitated from a pancreatic casein digest. 9 38
8675752 1995
43
IgA antibodies to Streptococcus mutans in caries-resistant and -susceptible children. 9 38
7937259 1994
44
Antimicrobial factors of saliva in relation to dental caries and salivary levels of mutans streptococci. 9 38
1644785 1992
45
Expression of type I collagen pro-alpha 2 chain mRNA in adult human permanent teeth as revealed by in situ hybridization. 9 38
1740554 1992
46
Sexual orientation-related oral health disparities in the United States. 38
30277565 2019
47
Survival analysis of caries incidence in African-American school-aged children. 38
30238461 2019
48
Spontaneous bone regeneration after surgical extraction of a horizontally impacted mandibular third molar: a retrospective panoramic radiograph analysis. 38
30915316 2019
49
Caries prevalence and associations with medications and medical comorbidities. 38
30440082 2019
50
Current and future options for dental pulp therapy. 38
30733839 2019

Variations for Dental Caries

Expression for Dental Caries

Search GEO for disease gene expression data for Dental Caries.

Pathways for Dental Caries

Pathways related to Dental Caries according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.44 STATH PRH2 PRH1 MUC7 MUC5B LPO

GO Terms for Dental Caries

Cellular components related to Dental Caries according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.86 PRH2 PRH1 MUC5B LTF LPO FGF10
2 extracellular region GO:0005576 9.5 TUFT1 STATH PRH2 MUC7 MUC5B LYZL2
3 extracellular matrix GO:0031012 9.35 TFIP11 ENAM DSPP DMBT1 AMELX
4 other organism cell membrane GO:0044218 9.16 MUC7 LTF

Biological processes related to Dental Caries according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.71 STATH LTF LPO HTN1
2 cellular protein metabolic process GO:0044267 9.67 LTF ENAM DMBT1 AMELX
3 ossification GO:0001503 9.63 STATH LTF DSPP
4 defense response to Gram-negative bacterium GO:0050829 9.61 LYZL2 LTF DMBT1
5 odontogenesis of dentin-containing tooth GO:0042475 9.5 FGF10 ENAM AMELX
6 detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 9.33 TAS2R38 LPO CA6
7 biomineral tissue development GO:0031214 9.17 TUFT1 TFIP11 STATH HTN1 ENAM DSPP
8 killing of cells of other organism GO:0031640 9.13 MUC7 LTF HTN1
9 positive regulation of enamel mineralization GO:0070175 8.96 ENAM

Molecular functions related to Dental Caries according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydroxyapatite binding GO:0046848 8.96 STATH AMELX
2 structural constituent of tooth enamel GO:0030345 8.92 TUFT1 STATH ENAM AMELX
3 protein binding GO:0005515 10.03 TUFT1 TFIP11 STATH PRH2 PRH1 MUC7

Sources for Dental Caries

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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