MCID: DNT012
MIFTS: 53

Dental Caries

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Dental Caries

MalaCards integrated aliases for Dental Caries:

Name: Dental Caries 12 74 54 43 15 17 71 32
Dental Caries Extending into Pulp 12
Dental Caries of Smooth Surface 12
Dental Caries Pit and Fissure 12
Smooth Surface Dental Caries 17

Classifications:



External Ids:

Disease Ontology 12 DOID:216
ICD9CM 34 521.0 521.07
MeSH 43 D003731
NCIt 49 C52593
SNOMED-CT 67 80967001
ICD10 32 K02 K02.6 K02.9
UMLS 71 C0011334 C1456145

Summaries for Dental Caries

Disease Ontology : 12 A teeth hard tissue disease that is characterized by damage to a tooth that can happen when decay-causing bacteria in your mouth make acids that attack the tooth’s surface, or enamel.

MalaCards based summary : Dental Caries, also known as dental caries extending into pulp, is related to dentin caries and root caries, and has symptoms including snoring and halitosis. An important gene associated with Dental Caries is TFIP11 (Tuftelin Interacting Protein 11), and among its related pathways/superpathways is Salivary secretion. The drugs Sorbitol and Ethanol have been mentioned in the context of this disorder. Affiliated tissues include testes, salivary gland and bone, and related phenotypes are Decreased hepcidin::fluc mRNA expression and Decreased viability

Wikipedia : 74 Tooth decay, also known as dental caries or cavities, is a breakdown of teeth due to acids made by... more...

Related Diseases for Dental Caries

Diseases related to Dental Caries via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 298)
# Related Disease Score Top Affiliating Genes
1 dentin caries 34.0 STATH DSPP
2 root caries 33.7 STATH LTF DSPP
3 enamel caries 33.1 TUFT1 STATH ENAM AMELX AMBN
4 dental fluorosis 31.6 TUFT1 ENAM DSPP AMELX AMBN
5 gingival recession 30.9 DSPP AMBN
6 capgras syndrome 30.7 PRH2 PRH1
7 dental pulp necrosis 30.6 DSPP AMELX
8 hypoplastic amelogenesis imperfecta 30.5 ENAM AMBN
9 amelogenesis imperfecta 30.1 TUFT1 ENAM DSPP AMELX AMBN
10 calvarial doughnut lesions with bone fragility 11.4
11 aplasia of lacrimal and salivary glands 11.4
12 epidermolysis bullosa dystrophica, autosomal dominant 11.3
13 flynn-aird syndrome 11.3
14 johnson neuroectodermal syndrome 11.3
15 cockayne syndrome a 11.3
16 cutis laxa, autosomal recessive, type iia 11.3
17 insensitivity to pain, congenital, with anhidrosis 11.3
18 osteopetrosis, autosomal recessive 1 11.3
19 timothy syndrome 11.3
20 cockayne syndrome 11.3
21 periapical granuloma 11.3
22 periapical periodontitis 11.3
23 benjamin syndrome 11.3
24 recessive dystrophic epidermolysis bullosa-generalized other 11.3
25 odontoclasia 11.0
26 gingivitis 10.9
27 periodontitis 10.8
28 body mass index quantitative trait locus 1 10.7
29 down syndrome 10.6
30 cerebral palsy 10.5
31 dentine erosion 10.5 TUFT1 TFIP11
32 body mass index quantitative trait locus 11 10.5
33 body mass index quantitative trait locus 9 10.5
34 body mass index quantitative trait locus 8 10.5
35 body mass index quantitative trait locus 4 10.5
36 body mass index quantitative trait locus 10 10.5
37 body mass index quantitative trait locus 7 10.5
38 body mass index quantitative trait locus 12 10.5
39 body mass index quantitative trait locus 14 10.5
40 body mass index quantitative trait locus 18 10.5
41 body mass index quantitative trait locus 19 10.5
42 body mass index quantitative trait locus 20 10.5
43 dental pulp calcification 10.5 ENAM DSPP
44 pulpitis 10.5
45 amelogenesis imperfecta, type ic 10.5 ENAM AMELX
46 chronic ethmoiditis 10.5 MUC7 MUC5B
47 cleft lip 10.5
48 pulp degeneration 10.5 DSPP AMBN
49 hair whorl 10.4
50 rickets 10.4

Comorbidity relations with Dental Caries via Phenotypic Disease Network (PDN): (show all 12)


Acute Apical Periodontitis Acute Cystitis
Acute Pericementitis Alzheimer Disease
Aortic Valve Disease 1 Deficiency Anemia
Familial Atrial Fibrillation Gingivitis
Heart Disease Periodontitis, Chronic
Periodontosis Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Dental Caries:



Diseases related to Dental Caries

Symptoms & Phenotypes for Dental Caries

UMLS symptoms related to Dental Caries:


snoring, halitosis

GenomeRNAi Phenotypes related to Dental Caries according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased hepcidin::fluc mRNA expression GR00253-A 9.43 AMBN AMELX DMBT1 LPO MUC5B TUFT1
2 Decreased viability GR00249-S 9.36 LTF TAS1R2
3 Decreased viability GR00381-A-1 9.36 LTF TAS1R2 TUFT1
4 Decreased viability GR00381-A-3 9.36 LTF TAS1R2 TUFT1
5 Decreased viability GR00402-S-2 9.36 LTF TAS1R2 TUFT1

Drugs & Therapeutics for Dental Caries

Drugs for Dental Caries (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 256)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sorbitol Approved Phase 4 50-70-4 5780
2
Ethanol Approved Phase 4 64-17-5 702
3
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
4
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 5311068 68602
5
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
6
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
7
Histamine Approved, Investigational Phase 4 51-45-6 774
8
Meperidine Approved Phase 4 57-42-1 4058
9
Hydroxyzine Approved Phase 4 68-88-2 3658
10
Iodine Approved, Investigational Phase 4 7553-56-2 807
11
Petrolatum Approved, Investigational Phase 4 8009-03-8
12
Imidacloprid Vet_approved Phase 4 105827-78-9 86418
13 Caseins Phase 4
14 Chelating Agents Phase 4
15 Adrenergic Agents Phase 4
16 Adrenergic Agonists Phase 4
17 Pharmaceutical Solutions Phase 4
18 Bifidobacterium Phase 4
19 Acidophilus Phase 4
20 Fluorophosphate Phase 4
21 Anti-Inflammatory Agents Phase 4
22 Sodium fluoride topical preparation Phase 4
23 Laxatives Phase 4
24 Cathartics Phase 4
25 Gastrointestinal Agents Phase 4
26 Adrenergic alpha-Agonists Phase 4
27 Fibrinolytic Agents Phase 4
28 Analgesics, Non-Narcotic Phase 4
29 Platelet Aggregation Inhibitors Phase 4
30 Cyclooxygenase Inhibitors Phase 4
31 Antipyretics Phase 4
32 Antirheumatic Agents Phase 4
33 Anti-Inflammatory Agents, Non-Steroidal Phase 4
34 Excitatory Amino Acid Antagonists Phase 4
35 Anesthetics, Dissociative Phase 4
36 Neurotransmitter Agents Phase 4
37 Anesthetics, General Phase 4
38 Dermatologic Agents Phase 4
39 Anesthetics, Intravenous Phase 4
40 Hypnotics and Sedatives Phase 4
41 Anti-Anxiety Agents Phase 4
42 Psychotropic Drugs Phase 4
43 GABA Modulators Phase 4
44 Analgesics Phase 4
45 Narcotics Phase 4
46 Histamine H1 Antagonists Phase 4
47 Histamine Antagonists Phase 4
48 Analgesics, Opioid Phase 4
49
Histamine Phosphate Phase 4 51-74-1 65513
50 Calcium, Dietary Phase 4

Interventional clinical trials:

(show top 50) (show all 744)
# Name Status NCT ID Phase Drugs
1 Dental Caries Management by Risk Assessment: Identification and Treatment of Risk Factors Among Israeli Defence Force (IDF) Personnel Unknown status NCT01142440 Phase 4
2 Discoloration of Carious Primary Teeth After Application of Silver Diamine Fluoride Versus Sodium Fluoride Varnish: A Randomized Clinical Trial Unknown status NCT03557996 Phase 4 Silver Diamine Fluoride;Sodium Fluoride Varnish
3 Postoperative Pain After Application of Silver Diamine Fluoride Verses Sodium Fluoride Varnish in Treatment of Carious Primary Teeth (A Randomized Clinical Trial) Unknown status NCT03554980 Phase 4 Silver Diamine Fluoride;Sodium Fluoride varnish
4 Phase 4 Study Prevention of Incipient Carious Lesions (White Spot Lesions) in Patients With Fixed Orthodontic Appliances Following the Application of Elmex Gel Unknown status NCT00268138 Phase 4 elmex gel
5 Post-operative Pain After Silver Diamine Fluoride Application in Primary Molars With Deep Caries Versus Interim Restorative Therapy Unknown status NCT03563534 Phase 4 Silver Diamine Fluoride;Glass Ionomer
6 Consumption Effect of Probiotic Products on Salivary Cariogenic Bacterial Counts in Preschool Children. Unknown status NCT02692625 Phase 4
7 Esthetic Effect of Casein Phosphopeptide-Amorphous Calcium Phosphate Varnish Versus Tricalcium Phosphate Varnish on Postorthodontic White Spot Lesions: A Randomized Pilot Study Unknown status NCT03217084 Phase 4 MI varnish GC;White varnish 3M
8 Anticaries Effect of Probiotic Lactobacillus Brevis CD2 (Lb CD2). A Randomized Double Blind Interventional Study. Unknown status NCT01778699 Phase 4
9 Prevention of Dental Caries Lesions With Fluoride Varnish in Erupting First Permanent Molars Completed NCT02592278 Phase 4 Fluoride Varnish;Control Group
10 Comparison of Enamel Remineralization Potential of Dentifrices Incorporating Different Fluoride Salts Using an in Situ Caries Model Completed NCT01128946 Phase 4 NaF;SnF;NaMFP
11 The Effectiveness of Sealants in Prevention of Occlusal Caries on Primary Molars Completed NCT01438866 Phase 4
12 A Study to Measure the Effect of Dentifrice Usage Regime on Delivery and Efficacy of Fluoride Using an In Situ Caries Model Completed NCT01563172 Phase 4 Sodium fluoride / silica and carbopol, 0.5g;Sodium fluoride / silica and carbopol, 1.5g;Sodium fluoride / silica and carbopol, 1.5g
13 Evaluation of Resin Modified Glass Ionomer Liner (Vitrebond™) Versus Calcium Hydroxide as Indirect Pulp Treatment Material Used in Deep Carious Lesions in Primary Molars: A Randomized Clinical Trial Completed NCT03770871 Phase 4 Indirect pulp treatment using Dycal (TM);Indirect pulp treatment using Vitrebond (TM )
14 Fuji Type VII Sealants Versus Resin Based Sealants. A Clinical Trial Completed NCT02795728 Phase 4
15 A 2-year Clinical Study on Postoperative Pulpal Complications Arising From the Absence of a Glass-ionomer Lining in Deep Occlusal Resin Composite Restorations Completed NCT01567514 Phase 4
16 Effect of the Amount of Fluoride Toothpaste on Fluoride Availability in the Oral Fluids in Children Completed NCT03455621 Phase 4
17 Impact of Maternal Xylitol Consumption on Mutans Sterptococci ,Plaque and Caries Levels in Children Completed NCT02036151 Phase 4 xylitol;fluoride varnish application
18 Therapeutic Effect of Two Fluoride Varnishes on White Spot Lesions: a Clinical Study Completed NCT00723515 Phase 4 sodium fluoride;sodium fluoride calcium fluoride
19 Evaluation of the Impact of Fluoride Vanish Application in Dental Prevention Among Institutionalised Elderly People Completed NCT01038817 Phase 4 Duraphat
20 Randomized Controlled Trial of Oral Sedatives for Moderate Sedation in Young Children Completed NCT00902395 Phase 4 Midazolam;Midazolam, ketamine
21 White Spot Lesion Development in Post-orthodontic Patients Following Weekly Application of a 1.25% Fluoride Gel Compared to Placebo Over 6 Months Completed NCT01329731 Phase 4 elmex® gelée;negative control (placebo)
22 A Randomized Clinical Trial on Preventive and Therapeutic Proximal Sealants Completed NCT02338180 Phase 4
23 Caries-preventive Effectiveness of a Dentifrice Containing 5.000 Ppm Fluoride - a Randomized Controlled Trial in Adolescents With Fixed Orthodontic Appliances Completed NCT01768390 Phase 4
24 Bifidobacterium Lactis BB12 and Xylitol Delivered With a Novel Slow-release Pacifier Completed NCT00638677 Phase 4
25 Comparison Of The Caries-Protective Effect Of Fluoride Varnish (Duraphat®) With Treatment As Usual In Nursery School Attendees Receiving Preventive Oral Health Support Through The Childsmile Oral Health Improvement Programme: An RCT Completed NCT01674933 Phase 4 Duraphat® Fluoride Varnish
26 Economic Evaluation of ART Sealant in Preventing Pit and Fissure Caries in Permanent First Molars in an Asia Population Completed NCT03034837 Phase 4 resin sealant;ART sealant
27 Partial Pulpotomy Treatment Of Immature Permanent Molars: A Randomized Clinical Trial Completed NCT03426046 Phase 4 Pulp Capping Agents
28 The Effect of Silver Diamine Fluoride (SDF) on Bacteria Involved in Root or Cervical Carious Lesions Using HOMINGS Technology. A Clinical Study Completed NCT02953886 Phase 4
29 Comparison of the Effect of Fluoride Remineralizer Gel and Foam: a Randomized Clinical Trial Completed NCT02490592 Phase 4
30 Efficacy, Safety and Cost-effectiveness of Intranasal Sedation With Ketamine and Midazolam in Pediatric Dentistry: a Randomized Clinical Trial Completed NCT02447289 Phase 4 Intranasal ketamine;Oral ketamine;Intranasal midazolam;Oral midazolam
31 Oral Fluoride Bioavailability by the Consumption of Meals Prepared With Fluoridated Water or Salt Completed NCT02776280 Phase 4
32 Effects of Two Sugar Substituted Chewing Gums Plus Tooth Brushing on Different Caries and Gingivitis Related Variables: a Double Blind, Randomized Controlled Clinical Trial Completed NCT01578603 Phase 4
33 Comparison of Topical Analgesic With Saline Rinses in Post Extraction Healing Among Hypertensive and Non-hypertensive Subjects Completed NCT02921165 Phase 4 analgesic mouth rinses (dissolved Aspirin);Normal saline rinses.
34 MI Varnish and MI Paste Plus in a Caries Prevention and Remineralization Study Completed NCT02424097 Phase 4 CPP-ACP 5% sodium fluoride varnish & 900ppm fluoride paste;1,100pm F-toothpaste and 0.5%NaF rinse
35 The Use of MI Varnish for the Prevention and Reduction of White Spot Lesions in Orthodontic Treatment Completed NCT03446690 Phase 4 MI Varnish
36 Dental Fluorosis Risk by the Use of Acidulated Fluoride Dentifrice: Clinical Trial - Epidemiological Study With Children Residing in an área Without Public Water Fluoridation Completed NCT03761485 Phase 4
37 Interaction Chlorhexidine-fluoride - a 4-day and 6-week Randomised Clinical Mouthrinse Study Completed NCT02935322 Phase 4 0.12 % chlorhexidine + 0.2 % NaF mouthrinse;0.2 % NaF mouthrinse;0.12% chlorhexidine
38 BiodentineTM Versus Formocresol Pulpotomy Technique in Primary Molars: A 12-Month Randomized Controlled Clinical Trial Completed NCT03779698 Phase 4 Formocresol
39 Intranasal Sedation With Dexmedetomidine and Ketamine in Pediatric Dentistry (NASO II): Randomized Clinical Trial Completed NCT03290625 Phase 4 Dexmedetomidine Hydrochloride;Ketamine Hydrochloride
40 Effect of Probiotic on the Plaque pH. A Randomized Double Blind Interventional Study Completed NCT01601145 Phase 4
41 FISSURE-Project. Improved Dental Decay Management in Dental Service for Children: Fissure Sealants or Fluoride Varnish? Recruiting NCT03315312 Phase 4 Fluoride Varnishes;Fissure Sealants
42 Clinical and Radiographic Evaluation of a New Bioactive Ionic Resin Material (ACTIVA™ BioACTIVE) Versus Compomer for Class II Restorations in Primary Molars: A Split Mouth Randomized Clinical Trial Recruiting NCT03516838 Phase 4 ACTIVA™ BioACTIVE;Compomer
43 Sedation Versus Protective Stabilization for Dental Treatment of Children With Caries and Negative Behavior at the Dentist: a Non-randomized Clinical Trial Recruiting NCT04119180 Phase 4 Ketamine 50 MG/ML;Midazolam Hcl 2Mg/Ml Syrup
44 Reminerlization Potential of Innovative Biomimetic Material Versus Casein Phosphopeptide-amorphous Calcium Phosphate in Caries White Spot Lesions "A Randomized Clinical Trial" Recruiting NCT03823612 Phase 4 Clinpro Tooth Creme;GC tooth mousse
45 Clinical Efficacy of Giomer Versus Sodium Fluoride Varnish for Management of Hypersensitivity: Randomized Control Trail Recruiting NCT03818945 Phase 4 shofu PRG barrier coat;Sodium fluoride varnish
46 The Effectiveness of Casein Phosphopeptide Amorphous Calcium Phosphate (MI Varnish) and 5% Sodium Fluoride Plus Xylitol (PreviDent Varnish) on Non Cavitated Interproximal Lesions. Randomised Clinical Trial Active, not recruiting NCT03925740 Phase 4 MI Varnish;PreviDent Varnish;1.23% APF
47 Comparing Pediatric Oral Sedation Outcomes Using Midazolam and Hydroxyzine With and Without Meperidine Active, not recruiting NCT04068948 Phase 4 Meperidine;Hydroxyzine;Midazolam
48 Comparative Evaluation of Staining Potential and Caries Arresting Effect of Silver Diamine Fluoride⁄Potassium Iodide and Silver Diamine Fluoride in Carious Primary Anterior Teeth Not yet recruiting NCT04196829 Phase 4 silver diamine fluoride ⁄ potassium Iodide;Silver Diamine Fluoride
49 Clinical and Radiographic Evaluation of Light Cured Resin Modified Calcium Silicate Versus Light Cured Calcium Hydroxide in Indirect Pulp Treatment of Primary Molars Not yet recruiting NCT03791255 Phase 4 Calcium silicate liner;Calcium hydroxide liner
50 Comparison of Silver Modified and Conventional Atraumatic Restorative Treatment Modalities in Primary Molars in a Group of Egyptian School Children. A Randomized Controlled Trial Not yet recruiting NCT03881020 Phase 4 Silver diamine Fluoride 38%

Search NIH Clinical Center for Dental Caries

Inferred drug relations via UMLS 71 / NDF-RT 50 :


aluminum chloride

Cochrane evidence based reviews: dental caries

Genetic Tests for Dental Caries

Anatomical Context for Dental Caries

MalaCards organs/tissues related to Dental Caries:

40
Testes, Salivary Gland, Bone, Colon, Heart, Thyroid, Breast

Publications for Dental Caries

Articles related to Dental Caries:

(show top 50) (show all 18012)
# Title Authors PMID Year
1
Analysis of the association between lactotransferrin (LTF) gene polymorphism and dental caries. 61 54
20485928 2010
2
Mucosal and systemic immunization with targeted fusion anti-caries DNA plasmid in young rats. 54 61
19428904 2009
3
[Oral health suggestion on dental caries, periodontal diseases, dentin hypersensitivity, and malocclusion]. 54 61
19575979 2009
4
[Relationship of concentration of lactoferrin and lysozyme in saliva and dental caries in primary dentition]. 54 61
19563039 2009
5
Assessment of the nanostructure of acid-base resistant zone by the application of all-in-one adhesive systems: Super dentin formation. 54 61
19581710 2009
6
Quantitative assessment of IgA levels in the unstimulated whole saliva of caries-free and caries-active children. 54 61
19008624 2008
7
Common dental infections in the primary care setting. 61 54
18386594 2008
8
Ammonium hexafluorosilicate elicits calcium phosphate precipitation and shows continuous dentin tubule occlusion. 61 54
17544103 2008
9
Composite restorations in the anterior region: clinical and aesthetic performances. 54 61
17970479 2007
10
Dentin in severe fluorosis: a quantitative histochemical study. 61 54
17720855 2007
11
Identification and subcellular localization of paracellin-1 (claudin-16) in human salivary glands. 54 61
17551748 2007
12
Effect of a papain-based gel for chemomechanical caries removal on dentin shear bond strength. 61 54
18477426 2007
13
A possible role of LIM mineralization protein 1 in tertiary dentinogenesis of dental caries treatment. 61 54
17374459 2007
14
Differential expression profiles of Streptococcus mutans ftf, gtf and vicR genes in the presence of dietary carbohydrates at early and late exponential growth phases. 61 54
16764842 2006
15
Criteria for a diagnosis of caries through the DIAGNOdent. 54 61
16503789 2006
16
Relationship between large tubules and dentin caries in human deciduous tooth. 54 61
16285599 2005
17
Matrix metalloproteinases (MMPs) in oral diseases. 54 61
15533204 2004
18
Correlation among mutans streptococci counts, dental caries, and IgA to Streptococcus mutans in saliva. 61 54
16089269 2004
19
Carbon dioxide laser in dental caries prevention. 61 54
15304298 2004
20
Both lactoferrin and iron influence aggregation and biofilm formation in Streptococcus mutans. 54 61
15222477 2004
21
Aluminum concentrations in human deciduous enamel and dentin related to dental caries. 61 54
15646261 2004
22
A historical glimpse of toothpick use: etiquette, oral and medical conditions. 61 54
12846259 2003
23
Microbiology and management of endodontic infections in children. 61 54
14604136 2003
24
Infectious complications of dental and periodontal diseases in the elderly population. 54 61
11941548 2002
25
Compositional and structural changes of human dentin following caries removal by Er,Cr:YSGG laser irradiation in primary teeth. 61 54
12175132 2002
26
Pulp-dentin biology in restorative dentistry. Part 4: Dental caries--characteristics of lesions and pulpal reactions. 61 54
11695140 2001
27
[Dental pain]. 61 54
11680189 2001
28
Presence or absence of tertiary dentinogenesis in relation to caries progression. 61 54
12640747 2001
29
A case report: arresting dental caries. 54 61
11603306 2001
30
A vaccine against dental caries: an overview. 54 61
11543691 2001
31
Hereditary and environmental dental findings in identification of human remains. 54 61
10946469 2000
32
In vitro dentinal surface reaction of 9.5% buffered hydrofluoric acid in repair of ceramic restorations: a scanning electron microscopic investigation. 61 54
10842137 2000
33
The relation between salivary IgA and caries in renal transplant patients. 61 54
10807716 2000
34
1H-NMR analysis of microbial-derived organic acids in primary root carious lesions and saliva. 54 61
10516616 1999
35
RVG-ui: a sensor to rival direct-exposure intra-oral x-ray film. 61 54
11351483 1999
36
Intranasal immunization against dental caries with a Streptococcus mutans-enriched fimbrial preparation. 54 61
10225844 1999
37
Hydrophobic interaction chromatography and capillary zone electrophoresis to explore the correlation between the isoenzymes of salivary alpha-amylase and dental caries. 54 61
10219681 1999
38
Occurrence and distribution of caries in 6-year-old children in Blekinge, Sweden. 61 54
10431342 1999
39
Can low accuracy disease risk predictor models improve health care using decision support systems? 61 54
9929285 1998
40
Phosphoprotein analysis of sequential extracts of human dentin and the determination of the subsequent remineralization potential of these dentin matrices. 54 61
9701661 1998
41
Immunoglobulin A reaction to oral streptococci in saliva of subjects with different combinations of caries and levels of mutans streptococci. 61 54
9467389 1997
42
Characterization of multiply phosphorylated peptides selectively precipitated from a pancreatic casein digest. 54 61
8675752 1995
43
IgA antibodies to Streptococcus mutans in caries-resistant and -susceptible children. 61 54
7937259 1994
44
Antimicrobial factors of saliva in relation to dental caries and salivary levels of mutans streptococci. 61 54
1644785 1992
45
Expression of type I collagen pro-alpha 2 chain mRNA in adult human permanent teeth as revealed by in situ hybridization. 54 61
1740554 1992
46
Dental caries diagnosis in digital radiographs using back-propagation neural network. 61
31949895 2020
47
Enamel defects and caries prevalence in preterm children aged 5-10 years in Dubai. 61
31873070 2020
48
Oral management strategies for radiotherapy of head and neck cancer. 61
32123547 2020
49
Effects of low-level fluoride exposure on glucose homeostasis in female NOD mice. 61
32334241 2020
50
Drug delivery based pharmacological enhancement and current insights of quercetin with therapeutic potential against oral diseases. 61
32521458 2020

Variations for Dental Caries

Expression for Dental Caries

Search GEO for disease gene expression data for Dental Caries.

Pathways for Dental Caries

Pathways related to Dental Caries according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.45 STATH PRH2 PRH1 MUC7 MUC5B LPO

GO Terms for Dental Caries

Cellular components related to Dental Caries according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.76 PRH2 PRH1 MUC5B LTF LPO DMBT1
2 extracellular region GO:0005576 9.53 TUFT1 STATH PRH2 MUC7 MUC5B LYZL2
3 extracellular matrix GO:0031012 9.35 TFIP11 ENAM DSPP DMBT1 AMELX

Biological processes related to Dental Caries according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.71 STATH LTF LPO HTN1
2 ossification GO:0001503 9.61 STATH LTF DSPP
3 defense response to Gram-negative bacterium GO:0050829 9.54 LYZL2 LTF DMBT1
4 odontogenesis of dentin-containing tooth GO:0042475 9.5 ENAM AMELX AMBN
5 detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 9.43 TAS2R38 LPO CA6
6 cellular protein metabolic process GO:0044267 9.35 LTF ENAM DMBT1 AMELX AMBN
7 killing of cells of other organism GO:0031640 9.33 MUC7 LTF HTN1
8 biomineral tissue development GO:0031214 9.23 TUFT1 TFIP11 STATH HTN1 ENAM DSPP

Molecular functions related to Dental Caries according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of tooth enamel GO:0030345 9.02 TUFT1 STATH ENAM AMELX AMBN
2 hydroxyapatite binding GO:0046848 8.96 STATH AMELX

Sources for Dental Caries

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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