MCID: DNT001
MIFTS: 43

Dental Fluorosis

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Dental Fluorosis

MalaCards integrated aliases for Dental Fluorosis:

Name: Dental Fluorosis 12 76 15
Intrinsic Enamel Discolouration of Fluorosis 12
Dental Fluorosis, Acquired 73
Mottling of Enamel 12
Fluorosis, Dental 44
Mottled Teeth 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13711
ICD10 33 K00.3
ICD9CM 35 520.3
MeSH 44 D009050
NCIt 50 C85059
SNOMED-CT 68 30265004
UMLS 73 C0026618

Summaries for Dental Fluorosis

MalaCards based summary : Dental Fluorosis, also known as intrinsic enamel discolouration of fluorosis, is related to amelogenesis imperfecta and dental caries, and has symptoms including toothache An important gene associated with Dental Fluorosis is COL1A2 (Collagen Type I Alpha 2 Chain), and among its related pathways/superpathways are Degradation of the extracellular matrix and Development_Hedgehog and PTH signaling pathways in bone and cartilage development. The drugs Cariostatic Agents and Protective Agents have been mentioned in the context of this disorder. Affiliated tissues include bone, thyroid and brain.

Wikipedia : 76 Dental fluorosis (also termed mottled enamel) is an extremely common disorder, characterized by... more...

Related Diseases for Dental Fluorosis

Diseases related to Dental Fluorosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)
# Related Disease Score Top Affiliating Genes
1 amelogenesis imperfecta 29.5 AMBN AMELX MMP20
2 dental caries 10.8
3 gingivitis 10.2
4 ehlers-danlos syndrome, classic type, 1 10.2 COL1A2 DSPP
5 osteogenesis imperfecta, type i 10.2 BGLAP COL1A2
6 endometrial disease 10.2 DSPP ESR1
7 postmenopausal atrophic vaginitis 10.2 ESR1 ESR2
8 vaginitis 10.2 ESR1 ESR2
9 osteogenesis imperfecta, type iv 10.1 COL1A2 DSPP
10 progesterone-receptor positive breast cancer 10.1 ESR1 ESR2
11 aromatase deficiency 10.1 BGLAP ESR1
12 progesterone resistance 10.1 ESR1 ESR2
13 gender identity disorder 10.1 ESR1 ESR2
14 estrogen excess 10.1 ESR1 ESR2
15 endometriosis of ovary 10.1 ESR1 ESR2
16 lobular neoplasia 10.1 ESR1 ESR2
17 dentinogenesis imperfecta 10.1 COL1A2 DSPP
18 diabetes insipidus 10.1
19 osteogenesis imperfecta, type iii 10.1 BGLAP COL1A2
20 spinal stenosis 10.1 COL1A2 TIMP1
21 brittle bone disorder 10.1 BGLAP COL1A2 DSPP
22 pelvic organ prolapse 10.1 ESR1 ESR2
23 bone resorption disease 10.1 BGLAP ESR1
24 tooth resorption 10.0 AMELX DSPP
25 dental pulp disease 10.0 AMELX DSPP
26 bone remodeling disease 10.0 BGLAP ESR1
27 primary pigmented nodular adrenocortical disease 10.0 ESR1 ESR2
28 tooth agenesis 10.0 COL1A2 DSPP MMP20
29 taurodontism 10.0
30 kashin-beck disease 10.0
31 dentin dysplasia 10.0
32 periodontal disease 10.0
33 amelogenesis imperfecta hypomaturation type 10.0 AMELX MMP20
34 hypophosphatemia 9.9 BGLAP DSPP
35 osteoporosis 9.9 BGLAP COL1A2 ESR1 ESR2
36 amelogenesis imperfecta, hypoplastic/hypomaturation, x-linked 2 9.9 AMBN AMELX
37 hypocalcified amelogenesis imperfecta 9.8 AMBN DSPP MMP20
38 dental pulp necrosis 9.8 AMBN AMELX DSPP
39 amelogenesis imperfecta, type iiia 9.7 AMBN AMELX MMP20
40 teeth hard tissue disease 9.6 AMBN AMELX DSPP MMP20

Graphical network of the top 20 diseases related to Dental Fluorosis:



Diseases related to Dental Fluorosis

Symptoms & Phenotypes for Dental Fluorosis

UMLS symptoms related to Dental Fluorosis:


toothache

Drugs & Therapeutics for Dental Fluorosis

Drugs for Dental Fluorosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Cariostatic Agents Phase 3,Phase 1,Not Applicable
2 Protective Agents Phase 3,Phase 1,Not Applicable
3 Fluorides Phase 3,Phase 1,Not Applicable
4 sodium fluoride Approved Phase 1,Not Applicable 7681-49-4
5
Calcium Carbonate Approved, Investigational Phase 1 471-34-1
6 Listerine Phase 1,Not Applicable
7 Gastrointestinal Agents Phase 1
8 Anti-Ulcer Agents Phase 1
9 Antacids Phase 1
10 Calcium, Dietary Phase 1,Not Applicable
11 Pharmaceutical Solutions Phase 1
12
Hydrogen peroxide Approved, Vet_approved Not Applicable 7722-84-1 784
13
Ethanol Approved Not Applicable 64-17-5 702
14 Anti-Infective Agents Not Applicable
15 Immunoconjugates Not Applicable
16 Immunologic Factors Not Applicable
17 Anti-Infective Agents, Local Not Applicable
18 Bone Density Conservation Agents Not Applicable
19 Anesthetics Not Applicable
20 Sodium fluoride topical preparation Not Applicable
21 Fluorides, Topical Not Applicable

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Dental Fluorosis Risk by the Use of Acidulated Fluoride Dentifrice Completed NCT03761485 Phase 4
2 Effect of pH and Fluoride Concentration of Dentifrices on Caries Control Completed NCT01049503 Phase 3
3 Anticaries Potential and Fluorosis Risk From Different Fluoride Toothpastes Completed NCT01589991 Phase 1 Toothpaste
4 Systemic Fluoride Bioavailability From Toothpastes Containing Calcium Carbonate or Silica as Abrasives Completed NCT01571050 Phase 1 Purified water;Fresh MFP/CaCO3 toothpaste;Fresh NaF/SiO2 toothpaste;Aged NaF/SiO2 toothpaste;Aged MFP/CaCO3 toothpaste
5 Fluoride Bioavailability After Ingestion of Water or Foods Prepared With Fluoridated Water Completed NCT01978041 Phase 1
6 Dental Health Epidemiology Among Israel Defense Forces (IDF) Recruits Unknown status NCT02958891
7 Presence of Enamel Fluorosis in Libyan Children Completed NCT03746990
8 Resin Infiltration and Resin Infiltration With Bleaching in Improving the Esthetics for Fluorosis Stains Completed NCT01733888 Not Applicable
9 Fluoride Intake From Toothbrushig With Children's or Regular Toothpastes Completed NCT01568541 Not Applicable Regular toothpastes;Children's toothpastes
10 Treatment of Hypersensitivity Using Diode Laser and Desensitising Agent on Fluorosed and Non-fluorosed Teeth Completed NCT03237793 Not Applicable
11 Using Eggshell Calcium to Mitigate Fluorosis in Ethiopia Active, not recruiting NCT03355222 Not Applicable
12 Iowa Fluoride Study/Iowa Bone Development Study Active, not recruiting NCT03547128
13 12 Month Follow up in Vivo Icon Study on Fluorotic Teeth Not yet recruiting NCT02925780 Not Applicable
14 Clinical Trial Proximal Caries Infiltration and Detection Terminated NCT01796106 Not Applicable

Search NIH Clinical Center for Dental Fluorosis

Cochrane evidence based reviews: fluorosis, dental

Genetic Tests for Dental Fluorosis

Anatomical Context for Dental Fluorosis

MalaCards organs/tissues related to Dental Fluorosis:

41
Bone, Thyroid, Brain, Kidney, Testes, Breast, Ovary

Publications for Dental Fluorosis

Articles related to Dental Fluorosis:

(show top 50) (show all 487)
# Title Authors Year
1
Dental fluorosis and associated risk factors in early adolescents in India. ( 29975665 )
2018
2
Comparative Analysis of Gene Expression Profiles of Human Dental Fluorosis and Kashin-Beck Disease. ( 29317700 )
2018
3
Dental Fluorosis over Time: A comparison of National Health and Nutrition Examination Survey data from 2001-2002 and 2011-2012. ( 29500282 )
2018
4
Dental Fluorosis Treatment Can Improve the Individuals' OHRQoL? Results from a Randomized Clinical Trial. ( 29898055 )
2018
5
Aesthetic Rehabilitation of a Severe Dental Fluorosis Case with Ceramic Veneers: A Step-by-Step Guide. ( 29977624 )
2018
6
Minimally invasive esthetic improvement in a patient with dental fluorosis by using microabrasion and bleaching: AA clinical report. ( 29724552 )
2018
7
Threshold effects of moderately excessive fluoride exposure on children's health: A potential association between dental fluorosis and loss of excellent intelligence. ( 29870912 )
2018
8
Exposure to fluoride of children during the critical age for dental fluorosis, in the semiarid region of Brazil. ( 29694589 )
2018
9
Brick tea consumption is a risk factor for dental caries and dental fluorosis among 12-year-old Tibetan children in Ganzi. ( 30483920 )
2018
10
Automatic detection and classification of dental fluorosis in vivo using white light and fluorescence imaging. ( 29929587 )
2018
11
Prevalence, severity, and request for treatment of dental fluorosis among adults in an endemic region of Northern Nigeria. ( 29988248 )
2018
12
The Effect of Dental Fluorosis on the Quality of Life of Female High School and Precollege Students of High Fluoride-Concentrated Area. ( 30123763 )
2018
13
Analysis of Polymorphisms in Genes Differentially Expressed in the Enamel of Mice with Different Genetic Susceptibilities to Dental Fluorosis. ( 30149392 )
2018
14
Comparative evaluation of three different recording criteria of dental fluorosis in a known endemic fluoride area of Haryana. ( 30168488 )
2018
15
Dental fluorosis and a polymorphism in the COL1A2 gene in Mexican children. ( 30172079 )
2018
16
A comparison of dental fluorosis in adult populations with and without lifetime exposure to water fluoridation. ( 30178518 )
2018
17
Interventions for dental fluorosis: A systematic review. ( 30194793 )
2018
18
The Prevalence and Associated Risk Indicators of Dental Fluorosis in China: Findings from the 4th National Oral Health Survey. ( 30255171 )
2018
19
Two-fold excess of fluoride in the drinking water has no obvious health effects other than dental fluorosis. ( 30262282 )
2018
20
Power bleaching enhances resin infiltration masking effect of dental fluorosis. A randomized clinical trial. ( 30342902 )
2018
21
Investigation on the Gradient Nanomechanical Behavior of Dental Fluorosis Enamel. ( 30377848 )
2018
22
How pH is regulated during amelogenesis in dental fluorosis. ( 30402142 )
2018
23
Estrogen receptor gene is associated with dental fluorosis in Brazilian children. ( 30539292 )
2018
24
Factors affecting dental fluorosis in low socioeconomic status children in Mexico. ( 28573833 )
2017
25
High prevalence of dental fluorosis among adolescents is a growing concern: a school based cross-sectional study from Southern India. ( 29165120 )
2017
26
Risk factors and prevalence of dental fluorosis and dental caries in school children of North India. ( 28025807 )
2017
27
A comparison of various minimally invasive techniques for the removal of dental fluorosis stains in children. ( 28762354 )
2017
28
High prevalence of dental fluorosis among schoolchildren in three villages in Vavuniya District: an observational study ( 29390597 )
2017
29
Protective effect of lycopene on fluoride-induced ameloblasts apoptosis and dental fluorosis through oxidative stress-mediated Caspase pathways. ( 27871895 )
2017
30
Microabrasion-remineralization (MAb-Re): An innovative approach for dental fluorosis. ( 28914255 )
2017
31
The effect of elemental content on the risk of dental fluorosis and the exposure of the environment and population to fluoride produced by coal-burning. ( 29101881 )
2017
32
Impact of caries and dental fluorosis on oral health-related quality of life: a cross-sectional study in schoolchildren receiving water naturally fluoridated at above-optimal levels. ( 28251432 )
2017
33
Prevalence of dental fluorosis in Mexico 2005-2015: a literature review. ( 28902318 )
2017
34
Polymorphisms in Nonamelogenin Enamel Matrix Genes Are Associated with Dental Fluorosis. ( 29207377 )
2017
35
Impact of Dental Fluorosis, Socioeconomic Status and Self-Perception in Adolescents Exposed to a High Level of Fluoride in Water. ( 28085102 )
2017
36
Polymorphisms in genes involved in enamel development are associated with dental fluorosis. ( 28131910 )
2017
37
Dental fluorosis, nutritional status, kidney damage, and thyroid function along with bone metabolic indicators in school-going children living in fluoride-affected hilly areas of Doda district, Jammu and Kashmir, India. ( 29063198 )
2017
38
Dietary Fluoride Intake and Associated Skeletal and Dental Fluorosis in School Age Children in Rural Ethiopian Rift Valley. ( 27472351 )
2016
39
The prevalence of dental fluorosis and its associated factors in Salem district. ( 27307668 )
2016
40
Prevalence of Dental Fluorosis and associated Risk Factors in Bagalkot District, Karnataka, India. ( 27843259 )
2016
41
Natural history and long-term impact of dental fluorosis: a prospective cohort study. ( 26763813 )
2016
42
Dental fluorosis, fluoride in urine, and nutritional status in adolescent students living in the rural areas of Guanajuato, Mexico. ( 28032042 )
2016
43
Fluoride Varnish Applications in Preschoolers and Dental Fluorosis in Permanent Incisors: Results of a Nested-cohort Study Within a Clinical Trial. ( 28206898 )
2016
44
Prevalence of dental fluorosis among primary school children in association with different water fluoride levels in Mysore district, Karnataka. ( 27237204 )
2016
45
LS8 cell apoptosis induced by NaF through p-ERK and p-JNK - a mechanism study of dental fluorosis. ( 27624793 )
2016
46
Caries with Dental Fluorosis and Oral Health Behaviour Among 12-Year School Children in Moderate-Fluoride Drinking Water Community in Quetta, Pakistan. ( 27671177 )
2016
47
Grading and quantification of dental fluorosis in zebrafish larva. ( 27300491 )
2016
48
Independent and Additive Effects of Different Sources of Fluoride and Dental Fluorosis. ( 27306248 )
2016
49
Chronic Exposure to Bisphenol A Exacerbates Dental Fluorosis in Growing Rats. ( 27257137 )
2016
50
Is there an association between the presence of dental fluorosis and dental trauma amongst school children? ( 26960108 )
2016

Variations for Dental Fluorosis

Expression for Dental Fluorosis

Search GEO for disease gene expression data for Dental Fluorosis.

Pathways for Dental Fluorosis

GO Terms for Dental Fluorosis

Cellular components related to Dental Fluorosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.76 AMBN AMELX BGLAP COL1A2 DSPP ESR2
2 extracellular matrix GO:0031012 9.35 AMELX COL1A2 DSPP MMP20 TIMP1
3 endoplasmic reticulum lumen GO:0005788 9.02 AMBN AMELX BGLAP COL1A2 TIMP1

Biological processes related to Dental Fluorosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.5 AMBN AMELX TIMP1
2 odontogenesis GO:0042476 9.26 BGLAP COL1A2
3 intracellular estrogen receptor signaling pathway GO:0030520 9.16 ESR1 ESR2
4 skeletal system development GO:0001501 9.13 BGLAP COL1A2 DSPP
5 biomineral tissue development GO:0031214 8.92 AMBN AMELX BGLAP DSPP

Molecular functions related to Dental Fluorosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.54 AMBN AMELX TIMP1
2 steroid hormone receptor activity GO:0003707 9.46 ESR1 ESR2
3 nuclear receptor activity GO:0004879 9.43 ESR1 ESR2
4 steroid binding GO:0005496 9.4 ESR1 ESR2
5 structural constituent of tooth enamel GO:0030345 9.32 AMBN AMELX
6 estrogen receptor activity GO:0030284 9.26 ESR1 ESR2
7 estrogen response element binding GO:0034056 9.16 ESR1 ESR2
8 hydroxyapatite binding GO:0046848 8.96 AMELX BGLAP
9 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding GO:0038052 8.62 ESR1 ESR2

Sources for Dental Fluorosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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