MCID: DNT001
MIFTS: 43

Dental Fluorosis

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Dental Fluorosis

MalaCards integrated aliases for Dental Fluorosis:

Name: Dental Fluorosis 12 76 15
Intrinsic Enamel Discolouration of Fluorosis 12
Dental Fluorosis, Acquired 73
Mottling of Enamel 12
Fluorosis, Dental 44
Mottled Teeth 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13711
ICD10 33 K00.3
ICD9CM 35 520.3
MeSH 44 D009050
NCIt 50 C85059
UMLS 73 C0026618

Summaries for Dental Fluorosis

MalaCards based summary : Dental Fluorosis, also known as intrinsic enamel discolouration of fluorosis, is related to dental caries and aromatase deficiency, and has symptoms including toothache An important gene associated with Dental Fluorosis is COL1A2 (Collagen Type I Alpha 2 Chain), and among its related pathways/superpathways are Degradation of the extracellular matrix and Cell adhesion_ECM remodeling. The drugs Cariostatic Agents and Fluorides have been mentioned in the context of this disorder. Affiliated tissues include bone, thyroid and testes.

Wikipedia : 76 Dental fluorosis (also termed mottled enamel) is an extremely common disorder, characterized by... more...

Related Diseases for Dental Fluorosis

Diseases related to Dental Fluorosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 dental caries 30.3 AMELX DSPP
2 aromatase deficiency 10.5 BGLAP ESR1
3 ehlers-danlos syndrome, classic type, 1 10.5 COL1A2 DSPP
4 endometrial disease 10.5 DSPP ESR1
5 osteogenesis imperfecta, type iv 10.5 COL1A2 DSPP
6 dentinogenesis imperfecta 10.4 COL1A2 DSPP
7 osteogenesis imperfecta, type iii 10.4 BGLAP COL1A2
8 bone remodeling disease 10.4 BGLAP ESR1
9 progesterone resistance 10.4 ESR1 ESR2
10 postmenopausal atrophic vaginitis 10.4 ESR1 ESR2
11 osteogenesis imperfecta, type i 10.4 BGLAP COL1A2
12 progesterone-receptor positive breast cancer 10.4 ESR1 ESR2
13 gender identity disorder 10.3 ESR1 ESR2
14 aging 10.3
15 estrogen excess 10.3 ESR1 ESR2
16 spinal stenosis 10.3 COL1A2 TIMP1
17 endometriosis of ovary 10.3 ESR1 ESR2
18 lobular neoplasia 10.3 ESR1 ESR2
19 vaginitis 10.3 ESR1 ESR2
20 hypophosphatemia 10.2 BGLAP DSPP
21 pelvic organ prolapse 10.2 ESR1 ESR2
22 brittle bone disorder 10.2 BGLAP COL1A2 DSPP
23 hypocalcified amelogenesis imperfecta 10.2 DSPP MMP20
24 female reproductive system disease 10.1 ESR1 ESR2
25 thyroiditis 10.1
26 idiopathic scoliosis 10.0 COL1A2 ESR1 ESR2
27 bone resorption disease 10.0 BGLAP ESR1 ESR2
28 burns 10.0
29 periodontitis 10.0
30 diabetes insipidus 10.0
31 endometrial adenocarcinoma 10.0 ESR1 ESR2
32 dental pulp necrosis 9.9 AMELX DSPP
33 tooth resorption 9.9 AMELX DSPP
34 tooth agenesis 9.9 COL1A2 DSPP MMP20
35 saethre-chotzen syndrome 9.8 BGLAP COL1A2
36 taurodontism 9.8
37 kashin-beck disease 9.8
38 amelogenesis imperfecta 9.8
39 dentin dysplasia 9.8
40 gingivitis 9.8
41 periodontal disease 9.8
42 sporadic breast cancer 9.8 ESR1 ESR2
43 amelogenesis imperfecta, type iiia 9.7 AMELX MMP20
44 osteoporosis 9.6 BGLAP COL1A2 ESR1 ESR2
45 amelogenesis imperfecta hypomaturation type 9.6 AMELX MMP20
46 teeth hard tissue disease 9.3 AMELX DSPP MMP20

Graphical network of the top 20 diseases related to Dental Fluorosis:



Diseases related to Dental Fluorosis

Symptoms & Phenotypes for Dental Fluorosis

UMLS symptoms related to Dental Fluorosis:


toothache

Drugs & Therapeutics for Dental Fluorosis

Drugs for Dental Fluorosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Cariostatic Agents Phase 3,Phase 1,Not Applicable
2 Fluorides Phase 3,Phase 1,Not Applicable
3 Protective Agents Phase 3,Phase 1,Not Applicable
4
Calcium Carbonate Approved, Investigational Phase 1 471-34-1
5 sodium fluoride Approved Phase 1,Not Applicable 7681-49-4
6 Listerine Phase 1,Not Applicable
7 Antacids Phase 1
8 Anti-Ulcer Agents Phase 1
9 Calcium, Dietary Phase 1,Not Applicable
10 Gastrointestinal Agents Phase 1
11 Pharmaceutical Solutions Phase 1
12
Ethanol Approved Not Applicable 64-17-5 702
13
Hydrogen peroxide Approved, Vet_approved Not Applicable 7722-84-1 784
14 Anti-Infective Agents Not Applicable
15 Anti-Infective Agents, Local Not Applicable
16 Immunoconjugates Not Applicable
17 Bone Density Conservation Agents Not Applicable
18 Fluorides, Topical Not Applicable
19 Sodium fluoride topical preparation Not Applicable
20 Anesthetics Not Applicable

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Effect of pH and Fluoride Concentration of Dentifrices on Caries Control Completed NCT01049503 Phase 3
2 Anticaries Potential and Fluorosis Risk From Different Fluoride Toothpastes Completed NCT01589991 Phase 1 Toothpaste
3 Systemic Fluoride Bioavailability From Toothpastes Containing Calcium Carbonate or Silica as Abrasives Completed NCT01571050 Phase 1 Purified water;Fresh MFP/CaCO3 toothpaste;Fresh NaF/SiO2 toothpaste;Aged NaF/SiO2 toothpaste;Aged MFP/CaCO3 toothpaste
4 Fluoride Bioavailability After Ingestion of Water or Foods Prepared With Fluoridated Water Completed NCT01978041 Phase 1
5 Resin Infiltration and Resin Infiltration With Bleaching in Improving the Esthetics for Fluorosis Stains Completed NCT01733888 Not Applicable
6 Fluoride Intake From Toothbrushig With Children's or Regular Toothpastes Completed NCT01568541 Not Applicable Regular toothpastes;Children's toothpastes
7 Treatment of Hypersensitivity Using Diode Laser and Desensitising Agent on Fluorosed and Non-fluorosed Teeth Completed NCT03237793 Not Applicable
8 Using Eggshell Calcium to Mitigate Fluorosis in Ethiopia Recruiting NCT03355222 Not Applicable
9 Clinical Trial Proximal Caries Infiltration and Detection Recruiting NCT01796106 Not Applicable
10 Dental Health Epidemiology Among Israel Defense Forces (IDF) Recruits Active, not recruiting NCT02958891
11 Iowa Fluoride Study/Iowa Bone Development Study Active, not recruiting NCT03547128
12 Action of Infiltration Resin Icon in Fluorosis, Clinical Trial, Monitoring for 12 Month Not yet recruiting NCT02925780 Not Applicable

Search NIH Clinical Center for Dental Fluorosis

Cochrane evidence based reviews: fluorosis, dental

Genetic Tests for Dental Fluorosis

Anatomical Context for Dental Fluorosis

MalaCards organs/tissues related to Dental Fluorosis:

41
Bone, Thyroid, Testes, Kidney, Brain

Publications for Dental Fluorosis

Articles related to Dental Fluorosis:

(show top 50) (show all 462)
# Title Authors Year
1
Dental fluorosis and associated risk factors in early adolescents in India. ( 29975665 )
2018
2
Comparative Analysis of Gene Expression Profiles of Human Dental Fluorosis and Kashin-Beck Disease. ( 29317700 )
2018
3
Dental Fluorosis over Time: A comparison of National Health and Nutrition Examination Survey data from 2001-2002 and 2011-2012. ( 29500282 )
2018
4
Dental Fluorosis Treatment Can Improve the Individuals' OHRQoL? Results from a Randomized Clinical Trial. ( 29898055 )
2018
5
Aesthetic Rehabilitation of a Severe Dental Fluorosis Case with Ceramic Veneers: A Step-by-Step Guide. ( 29977624 )
2018
6
Minimally invasive esthetic improvement in a patient with dental fluorosis by using microabrasion and bleaching: AA clinical report. ( 29724552 )
2018
7
Threshold effects of moderately excessive fluoride exposure on children's health: A potential association between dental fluorosis and loss of excellent intelligence. ( 29870912 )
2018
8
Exposure to fluoride of children during the critical age for dental fluorosis, in the semiarid region of Brazil. ( 29694589 )
2018
9
Automatic detection and classification of dental fluorosis in vivo using white light and fluorescence imaging. ( 29929587 )
2018
10
Factors affecting dental fluorosis in low socioeconomic status children in Mexico. ( 28573833 )
2017
11
High prevalence of dental fluorosis among adolescents is a growing concern: a school based cross-sectional study from Southern India. ( 29165120 )
2017
12
Risk factors and prevalence of dental fluorosis and dental caries in school children of North India. ( 28025807 )
2017
13
A comparison of various minimally invasive techniques for the removal of dental fluorosis stains in children. ( 28762354 )
2017
14
High prevalence of dental fluorosis among schoolchildren in three villages in Vavuniya District: an observational study ( 29390597 )
2017
15
Protective effect of lycopene on fluoride-induced ameloblasts apoptosis and dental fluorosis through oxidative stress-mediated Caspase pathways. ( 27871895 )
2017
16
Microabrasion-remineralization (MAb-Re): An innovative approach for dental fluorosis. ( 28914255 )
2017
17
The effect of elemental content on the risk of dental fluorosis and the exposure of the environment and population to fluoride produced by coal-burning. ( 29101881 )
2017
18
Impact of caries and dental fluorosis on oral health-related quality of life: a cross-sectional study in schoolchildren receiving water naturally fluoridated at above-optimal levels. ( 28251432 )
2017
19
Prevalence of dental fluorosis in Mexico 2005-2015: a literature review. ( 28902318 )
2017
20
Polymorphisms in Nonamelogenin Enamel Matrix Genes Are Associated with Dental Fluorosis. ( 29207377 )
2017
21
Impact of Dental Fluorosis, Socioeconomic Status and Self-Perception in Adolescents Exposed to a High Level of Fluoride in Water. ( 28085102 )
2017
22
Polymorphisms in genes involved in enamel development are associated with dental fluorosis. ( 28131910 )
2017
23
Dental fluorosis, nutritional status, kidney damage, and thyroid function along with bone metabolic indicators in school-going children living in fluoride-affected hilly areas of Doda district, Jammu and Kashmir, India. ( 29063198 )
2017
24
Dietary Fluoride Intake and Associated Skeletal and Dental Fluorosis in School Age Children in Rural Ethiopian Rift Valley. ( 27472351 )
2016
25
The prevalence of dental fluorosis and its associated factors in Salem district. ( 27307668 )
2016
26
Prevalence of Dental Fluorosis and associated Risk Factors in Bagalkot District, Karnataka, India. ( 27843259 )
2016
27
Natural history and long-term impact of dental fluorosis: a prospective cohort study. ( 26763813 )
2016
28
Dental fluorosis, fluoride in urine, and nutritional status in adolescent students living in the rural areas of Guanajuato, Mexico. ( 28032042 )
2016
29
Fluoride Varnish Applications in Preschoolers and Dental Fluorosis in Permanent Incisors: Results of a Nested-cohort Study Within a Clinical Trial. ( 28206898 )
2016
30
Prevalence of dental fluorosis among primary school children in association with different water fluoride levels in Mysore district, Karnataka. ( 27237204 )
2016
31
LS8 cell apoptosis induced by NaF through p-ERK and p-JNK - a mechanism study of dental fluorosis. ( 27624793 )
2016
32
Caries with Dental Fluorosis and Oral Health Behaviour Among 12-Year School Children in Moderate-Fluoride Drinking Water Community in Quetta, Pakistan. ( 27671177 )
2016
33
Grading and quantification of dental fluorosis in zebrafish larva. ( 27300491 )
2016
34
Independent and Additive Effects of Different Sources of Fluoride and Dental Fluorosis. ( 27306248 )
2016
35
Chronic Exposure to Bisphenol A Exacerbates Dental Fluorosis in Growing Rats. ( 27257137 )
2016
36
Is there an association between the presence of dental fluorosis and dental trauma amongst school children? ( 26960108 )
2016
37
Validation of ICMR index for identification of dental fluorosis in epidemiological studies. ( 27834326 )
2016
38
Application of quantitative light-induced fluorescence to determine the depth of demineralization of dental fluorosis in enamel microabrasion: a case report. ( 27508165 )
2016
39
Dental fluorosis and urinary fluoride concentration as a reflection of fluoride exposure and its impact on IQ level and BMI of children of Laxmisagar, Simlapal Block of Bankura District, W.B., India. ( 26960765 )
2016
40
Prevalence and severity of dental fluorosis in four English cities. ( 28537367 )
2016
41
Dental Fluorosis and Catalase Immunoreactivity of the Brain Tissues in Rats Exposed to High Fluoride Pre- and Postnatally. ( 27052310 )
2016
42
Enzymatic Activity of Glutathione S-Transferase and Dental Fluorosis Among Children Receiving Two Different Levels of Naturally Fluoridated Water. ( 27449362 )
2016
43
The prevalence of dental fluorosis and exposure to fluoride in drinking water: A systematic review. ( 27651877 )
2016
44
Dental fluorosis in the Blue Mountains and Hawkesbury, New South Wales, Australia: policy implications. ( 25511082 )
2015
45
Comment on "Severe dental fluorosis and cognitive deficits". ( 25986437 )
2015
46
Adult perceptions of dental fluorosis and select dental conditions-an Asian perspective. ( 26564646 )
2015
47
Association of Temporomandibular Joint Signs & Symptoms with Dental Fluorosis & Skeletal Manifestations in Endemic Fluoride Areas of Dungarpur District, Rajasthan, India. ( 26816986 )
2015
48
Dental fluorosis and its influence on children's life. ( 25590503 )
2015
49
Dental fluorosis: A histological study using Light and Confocal microscopy. ( 26275189 )
2015
50
Nutritional status and dental fluorosis among schoolchildren in communities with different drinking water fluoride concentrations in a central region in Mexico. ( 26426374 )
2015

Variations for Dental Fluorosis

Expression for Dental Fluorosis

Search GEO for disease gene expression data for Dental Fluorosis.

Pathways for Dental Fluorosis

GO Terms for Dental Fluorosis

Cellular components related to Dental Fluorosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 AMELX BGLAP COL1A2 DSPP ESR2 MMP20
2 extracellular matrix GO:0031012 9.33 COL1A2 MMP20 TIMP1
3 endoplasmic reticulum lumen GO:0005788 8.92 AMELX BGLAP COL1A2 TIMP1

Biological processes related to Dental Fluorosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid hormone mediated signaling pathway GO:0043401 9.32 ESR1 ESR2
2 odontogenesis GO:0042476 9.26 BGLAP COL1A2
3 intracellular estrogen receptor signaling pathway GO:0030520 9.16 ESR1 ESR2
4 skeletal system development GO:0001501 9.13 BGLAP COL1A2 DSPP
5 biomineral tissue development GO:0031214 8.8 AMELX BGLAP DSPP

Molecular functions related to Dental Fluorosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 9.73 ESR1 ESR2 MMP20 TIMP1
2 extracellular matrix structural constituent GO:0005201 9.48 COL1A2 DSPP
3 steroid hormone receptor activity GO:0003707 9.46 ESR1 ESR2
4 nuclear receptor activity GO:0004879 9.4 ESR1 ESR2
5 core promoter sequence-specific DNA binding GO:0001046 9.37 ESR1 ESR2
6 steroid binding GO:0005496 9.32 ESR1 ESR2
7 estrogen receptor activity GO:0030284 9.26 ESR1 ESR2
8 estrogen response element binding GO:0034056 9.16 ESR1 ESR2
9 hydroxyapatite binding GO:0046848 8.96 AMELX BGLAP
10 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding GO:0038052 8.62 ESR1 ESR2

Sources for Dental Fluorosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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