MCID: DNT001
MIFTS: 43

Dental Fluorosis

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Dental Fluorosis

MalaCards integrated aliases for Dental Fluorosis:

Name: Dental Fluorosis 12 74 15 17
Mottled Teeth 12 32
Intrinsic Enamel Discolouration of Fluorosis 12
Dental Fluorosis, Acquired 71
Mottling of Enamel 12
Fluorosis, Dental 44

Classifications:



External Ids:

Disease Ontology 12 DOID:13711
ICD9CM 34 520.3
MeSH 44 D009050
NCIt 50 C85059
SNOMED-CT 67 30265004
ICD10 32 K00.3
UMLS 71 C0026618

Summaries for Dental Fluorosis

MalaCards based summary : Dental Fluorosis, also known as mottled teeth, is related to dental caries and periodontitis, and has symptoms including toothache An important gene associated with Dental Fluorosis is MMP20 (Matrix Metallopeptidase 20), and among its related pathways/superpathways are Glioma and Degradation of the extracellular matrix. The drugs Protective Agents and Calcium carbonate have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and kidney, and related phenotypes are growth/size/body region and craniofacial

Wikipedia : 74 Dental fluorosis is a common disorder, characterized by hypomineralization of tooth enamel caused by... more...

Related Diseases for Dental Fluorosis

Diseases related to Dental Fluorosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)
# Related Disease Score Top Affiliating Genes
1 dental caries 30.4 MMP2 ENAM DSPP AMELX AMBN
2 periodontitis 30.3 MMP9 MMP2 BGLAP
3 osteoporosis 29.7 MMP9 ESR2 ESR1 COL1A2 BGLAP
4 hypercementosis 29.1 MMP20 ENAM DSPP AMELX AMBN
5 dentin dysplasia 29.1 MMP20 ENAM DSPP AMELX AMBN
6 amelogenesis imperfecta 27.4 ODAM MMP9 MMP20 ESR2 ESR1 ENAM
7 gingivitis 10.3
8 nonmucinous bronchioloalveolar adenocarcinoma 10.3 ESR2 ESR1
9 bile duct cystadenoma 10.3 ESR2 ESR1
10 postmenopausal atrophic vaginitis 10.3 ESR2 ESR1
11 enamel erosion 10.2 MMP20 AMELX
12 root caries 10.2 DSPP AMELX
13 progesterone resistance 10.2 ESR2 ESR1
14 dental pulp necrosis 10.2 DSPP BGLAP AMELX
15 dental pulp disease 10.2 DSPP BGLAP AMELX
16 hair whorl 10.2
17 vaginal cancer 10.2 ESR2 ESR1
18 amelogenesis imperfecta hypomaturation type 10.2 MMP20 AMELX
19 idiopathic scoliosis 10.1 ESR2 ESR1 COL1A2
20 amelogenesis imperfecta, hypomaturation type, iia2 10.1 MMP20 AMTN
21 progesterone-receptor positive breast cancer 10.1 ESR2 ESR1
22 gender identity disorder 10.1 ESR2 ESR1 AMELX
23 extracranial arteriovenous malformation 10.1 MMP9 MMP2
24 suppurative periapical periodontitis 10.1 DSPP AMBN
25 focal myositis 10.1 MMP9 MMP2
26 spastic entropion 10.1 MMP9 MMP2
27 acute transverse myelitis 10.1 MMP9 MMP2
28 lentigo maligna melanoma 10.1 MMP9 MMP2
29 nasal cavity squamous cell carcinoma 10.1 MMP9 MMP2
30 hermansky-pudlak syndrome 6 10.1 AMELX AMBN
31 light chain deposition disease 10.1 MMP9 MMP2
32 senile ectropion 10.1 MMP9 MMP2
33 dentin caries 10.1 MMP20 MMP2 DSPP
34 gingival recession 10.1 DSPP AMBN
35 odontogenic myxoma 10.1 MMP9 MMP2
36 bone mineral density quantitative trait locus 8 10.1
37 bone mineral density quantitative trait locus 15 10.1
38 diabetes insipidus 10.1
39 nasal cavity benign neoplasm 10.1 MMP9 MMP2
40 estrogen excess 10.1 ESR2 ESR1
41 osteogenesis imperfecta, type vii 10.1 COL1A2 BGLAP
42 bone resorption disease 10.0 ESR2 ESR1 COL1A2 BGLAP
43 bone remodeling disease 10.0 ESR2 ESR1 COL1A2 BGLAP
44 parotitis 10.0 MMP9 MMP2
45 oral submucous fibrosis 10.0 MMP9 MMP2 COL1A2
46 ductal carcinoma in situ 10.0 MMP9 ESR2 ESR1
47 fallopian tube carcinoma 10.0 MMP9 MMP2 ESR1
48 periapical periodontitis 10.0 MMP9 MMP2 DSPP
49 hyperostosis 10.0 MMP9 MMP2 COL1A2
50 aggressive periodontitis 10.0 MMP9 MMP2 BGLAP

Graphical network of the top 20 diseases related to Dental Fluorosis:



Diseases related to Dental Fluorosis

Symptoms & Phenotypes for Dental Fluorosis

UMLS symptoms related to Dental Fluorosis:


toothache

MGI Mouse Phenotypes related to Dental Fluorosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.73 AMBN AMTN COL1A2 DLX1 DLX2 ENAM
2 craniofacial MP:0005382 9.7 AMBN AMTN DLX1 DLX2 ENAM MMP2
3 skeleton MP:0005390 9.4 AMBN AMTN BGLAP COL1A2 DLX1 DLX2

Drugs & Therapeutics for Dental Fluorosis

Drugs for Dental Fluorosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Protective Agents Phase 4
2
Calcium carbonate Approved, Investigational Phase 1 471-34-1
3 sodium fluoride Approved Phase 1 7681-49-4
4 Anti-Ulcer Agents Phase 1
5 Antacids Phase 1
6 Fluorides Phase 1
7 Calcium, Dietary Phase 1
8 Gastrointestinal Agents Phase 1
9 Pharmaceutical Solutions Phase 1
10 Listerine Phase 1
11
Calcium Nutraceutical Phase 1 7440-70-2 271
12
Hydrogen peroxide Approved, Vet_approved 7722-84-1 784
13
Ethanol Approved 64-17-5 702
14
Salicylic acid Approved, Investigational, Vet_approved 69-72-7 338
15 Immunologic Factors
16 Anti-Infective Agents
17 Immunoconjugates
18 Anti-Infective Agents, Local

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Dental Fluorosis Risk by the Use of Acidulated Fluoride Dentifrice: Clinical Trial - Epidemiological Study With Children Residing in an área Without Public Water Fluoridation Completed NCT03761485 Phase 4
2 Effect of pH and Fluoride Concentration of Liquid Dentifrices on Caries Control in a Fluoridated Area: a Randomized Clinical Trial Completed NCT01049503 Phase 3
3 Systemic Fluoride Bioavailability From Toothpastes Containing Calcium Carbonate or Silica as Abrasives Completed NCT01571050 Phase 1 Purified water;Fresh MFP/CaCO3 toothpaste;Fresh NaF/SiO2 toothpaste;Aged NaF/SiO2 toothpaste;Aged MFP/CaCO3 toothpaste
4 Fluoride Bioavailability in Plasma and Saliva After Ingestion of Water or Foods Prepared With Fluoridated Water Completed NCT01978041 Phase 1
5 Anticaries Potential and Fluorosis Risk From Different Fluoride Toothpastes Completed NCT01589991 Phase 1 Toothpaste
6 Caries, Gingivitis, Dental Trauma and Fluorosis Prevalence Among IDF Recruits - an Epidemiological Survey Unknown status NCT02958891
7 Fluoride Intake From Tooth Brushing With Children's and Regular Toothpastes: a Study With Preschooler Children Completed NCT01568541 Regular toothpastes;Children's toothpastes
8 Evaluation of Degree of Enamel Fluorosis in Children of Tobruk and Kufra Regions in Libya Completed NCT03746990
9 Treatment of Hypersensitivity Using Diode Laser and Potassium Nitrate Desensitising Agent- a Comparison of Treatment Effects on Fluorosed and Non-fluorosed Teeth- an in Vivo Randomised Controlled Trial Completed NCT03237793
10 Evaluating the Effect of Resin Infiltration and Resin Infiltration With Bleaching in Improving the Esthetics for Non Pitted Fluorosis Stains in Indian Population Completed NCT01733888
11 Using Eggshell Calcium to Mitigate Fluorosis in Ethiopia Completed NCT03355222
12 Iowa Fluoride Study/Iowa Bone Development Study Active, not recruiting NCT03547128
13 In Vivo Action of Infiltrating Resin Icon® on Fluorosis - a 12 Month Follow up Trial Not yet recruiting NCT02925780
14 Colorimetric Comparison of Email Defects Using Spectrophotometric and Computer Techniques and Biological, Structural and Physico-chemical Analyses of Teeth or Pathological Enamel Not yet recruiting NCT04704089

Search NIH Clinical Center for Dental Fluorosis

Cochrane evidence based reviews: fluorosis, dental

Genetic Tests for Dental Fluorosis

Anatomical Context for Dental Fluorosis

MalaCards organs/tissues related to Dental Fluorosis:

40
Thyroid, Bone, Kidney, Whole Blood, Brain, Testis, T Cells

Publications for Dental Fluorosis

Articles related to Dental Fluorosis:

(show top 50) (show all 1417)
# Title Authors PMID Year
1
miR-122-5p Mediates Fluoride-Induced Osteoblast Activation by Targeting CDK4. 61
32572801 2021
2
Altered miRNA expression profiling in enamel organ of fluoride affected rat embryos. 61
33418158 2021
3
Refinement Impairments of Verbal-Performance Intelligent Quotient in Children Exposed to Fluoride Produced by Coal Burning. 61
32363519 2021
4
Effects of water improvement and defluoridation on fluorosis-endemic areas in China: A meta-analysis. 61
33333408 2021
5
Effect of Fluoride in Drinking Water on Fecal Microbial Community in Rats. 61
33576944 2021
6
Structural changes in the oral microbiome of the adolescent patients with moderate or severe dental fluorosis. 61
33536555 2021
7
Dental Fluorosis and Periodontium: an Original Research Report of In Vitro and In Vivo Institutional Studies. 61
33405081 2021
8
Does dental fluorosis affect electric pulp test response and/or optimum probe placement site? 61
33438314 2021
9
Epidemiology of Erosive Tooth Wear, Dental Fluorosis and Molar Incisor Hypomineralization in the American Continent. 61
33440378 2021
10
Evaluating the Association Between Dental Fluorosis and Polymorphisms in Bone Development and Mineralization Genes Among Population from a Fluoride Endemic Region of Eastern India. 61
32185656 2021
11
Determination of the Fluoride Content in Water of Aqueducts of Cauca (Colombia) by Ion Exchange Chromatography. 61
33405075 2021
12
Fluoride Geochemistry and Exposure Risk Through Groundwater Sources in Northeastern Parts of Rajasthan, India. 61
33388840 2021
13
Surface properties and Streptococcus mutans - Streptococcus sanguinis adhesion of fluorotic enamel. 61
33202357 2021
14
MAP kinase phosphatase MKP-1 regulates p-ERK1/2 signaling pathway with fluoride treatment. 61
33493990 2021
15
Oral health status of 12-year-old children in Lisu minority ethnic group in China: a cross-sectional study. 61
33435927 2021
16
Fluoride and arsenic contamination in drinking water due to mining activities and its impact on local area population. 61
32880840 2021
17
Risk assessment of fluoride daily intake from preference beverage. 61
33384801 2021
18
Open-Source Portable Device for the Determination of Fluoride in Drinking Water. 61
33415970 2021
19
Curcumin suppresses cell growth and attenuates fluoride-mediated Caspase-3 activation in ameloblast-like LS8 cells. 61
33486250 2021
20
A stereolithographic template for computer-assisted teeth preparation in dental esthetic ceramic veneer treatment. 61
32851792 2020
21
Missing and decayed teeth, oral hygiene and dental staining in relation to esophageal cancer risk: ESCCAPE case-control study in Kilimanjaro, Tanzania. 61
33320959 2020
22
Minimal intervention treatment of crown-root fracture in a mature permanent tooth by MTA pulpotomy and Fragment Reattachment: A Case Report. 61
33314383 2020
23
Resin Infiltration in Dental Fluorosis Treatment-1-Year Follow-Up. 61
33383755 2020
24
The impact of stopping or reducing the level of fluoride in public water supplies on dental fluorosis: a systematic review. 61
32598322 2020
25
Hydrogeochemistry and fluoride contamination in Jiaokou Irrigation District, Central China: Assessment based on multivariate statistical approach and human health risk. 61
32886997 2020
26
Esthetic Management of Incisors with Diffuse and Demarcated Opacities: 24 Month Follow-up Case Report. 61
32516394 2020
27
Calcium and Vitamin D Supplementation Effectively Alleviates Dental and Skeletal Fluorosis and Retain Elemental Homeostasis in Mice. 61
33057951 2020
28
Fluoride contamination in and around selected geothermal sites in Odisha, Eastern India: assessment of ionic relations, fluoride exposure and remediation. 61
33001397 2020
29
[Study of masking ability of laminate veneers for discolored teeth]. 61
33047734 2020
30
Relationship between dental fluorosis and I.Q of school going children aged 10-12 years in and around Nalgonda district-A cross-sectional study. 61
33402613 2020
31
Minimally invasive esthetic management of dental fluorosis: a case report. 61
33121307 2020
32
Impact of dental fluorosis on the oral health related quality of life among 11- to 14-year-old school children in endemic fluoride areas of Haryana (India). 61
32358889 2020
33
Clinical Performance of Enamel Microabrasion for Esthetic Management of Stained Dental Fluorosis Teeth. 61
32926733 2020
34
DENTAL FLUOROSIS PREVALENCE, SEVERITY AND ASSOCIATED RISK FACTORS IN PRE-SCHOOL AGED CHILDREN RESIDING IN FLUORIDE DEFICIENT REGIONS OF GEORGIA. 61
33130647 2020
35
Molar-incisor hypomineralization (MIH), dental fluorosis, and caries in rural areas with different fluoride levels in the drinking water. 61
32965763 2020
36
Esthetic management of white spot lesions by using minimal intervention techniques of bleaching and resin infiltration: A clinical report. 61
33008631 2020
37
Surface Nanohardness of Normal and Fluorosed Enamel Adjacent to Restorative Materials: An In Vitro Study and Polarized Light Microscopy Analysis. 61
33568592 2020
38
Marginalization and fluorosis its relationship with dental caries in rural children in Mexico: A cross-sectional study. 61
32338469 2020
39
Effects of Fluoride on Oxidative Stress Markers of Lipid, Gene, and Protein in Rats. 61
32789643 2020
40
Single nucleotide polymorphism rs4284505 in microRNA17 and risk of dental fluorosis. 61
32619376 2020
41
Conservative esthetic management of severe dental fluorosis with in-office power bleaching. 61
32820736 2020
42
Dental Fluorosis: the Risk of Misdiagnosis-a Review. 61
32705431 2020
43
Radionuclide activity concentration in soil, granites and water in a fluorosis endemic area of India: An oral health perspective. 61
32509515 2020
44
Geochemical evaluation of fluoride contamination in groundwater from Shanmuganadhi River basin, South India: implication on human health. 61
31705400 2020
45
Relationship between gingival bleeding and associated factors with reports of verbal bullying in adolescents. 61
32716571 2020
46
Protections against toxicity in the brains of rat with chronic fluorosis and primary neurons exposed to fluoride by resveratrol involves nicotinic acetylcholine receptors. 61
32142957 2020
47
Spatial distribution of endemic fluorosis caused by drinking water in a high-fluorine area in Ningxia, China. 61
32239411 2020
48
Dental fluorosis in the Australian adult population. 61
32583583 2020
49
At-home dental bleaching and resin infiltration seem to provide important benefits for young patients with dental fluorosis. 61
32303359 2020
50
Effect of Fluoride Concentration in Drinking Water on Dental Fluorosis in Southwest Saudi Arabia. 61
32492867 2020

Variations for Dental Fluorosis

Expression for Dental Fluorosis

Search GEO for disease gene expression data for Dental Fluorosis.

Pathways for Dental Fluorosis

GO Terms for Dental Fluorosis

Cellular components related to Dental Fluorosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.9 ODAM MMP9 MMP20 MMP2 ENAM DSPP
2 collagen-containing extracellular matrix GO:0062023 9.56 MMP9 MMP2 COL1A2 AMELX
3 endoplasmic reticulum lumen GO:0005788 9.43 ENAM COL1A2 BGLAP AMTN AMELX AMBN
4 extracellular matrix GO:0031012 9.23 MMP9 MMP20 MMP2 ENAM DSPP COL1A2

Biological processes related to Dental Fluorosis according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.9 ENAM AMTN AMELX AMBN
2 ossification GO:0001503 9.76 MMP9 DSPP BGLAP
3 skeletal system development GO:0001501 9.73 MMP9 DSPP COL1A2 BGLAP
4 extracellular matrix disassembly GO:0022617 9.7 MMP9 MMP20 MMP2
5 extracellular matrix organization GO:0030198 9.65 MMP9 MMP20 MMP2 DSPP COL1A2
6 collagen catabolic process GO:0030574 9.63 MMP9 MMP20 MMP2
7 cellular protein metabolic process GO:0044267 9.63 ODAM MMP2 ENAM AMTN AMELX AMBN
8 intracellular estrogen receptor signaling pathway GO:0030520 9.61 ESR2 ESR1
9 embryo development GO:0009790 9.61 DLX2 DLX1
10 response to amyloid-beta GO:1904645 9.59 MMP9 MMP2
11 cellular response to UV-A GO:0071492 9.58 MMP9 MMP2
12 negative regulation of oligodendrocyte differentiation GO:0048715 9.57 DLX2 DLX1
13 intracellular steroid hormone receptor signaling pathway GO:0030518 9.56 ESR2 ESR1
14 forebrain neuron differentiation GO:0021879 9.55 DLX2 DLX1
15 amelogenesis GO:0097186 9.54 MMP20 ENAM
16 negative regulation of photoreceptor cell differentiation GO:0046533 9.51 DLX2 DLX1
17 subpallium development GO:0021544 9.49 DLX2 DLX1
18 cerebral cortex GABAergic interneuron differentiation GO:0021892 9.48 DLX2 DLX1
19 odontogenesis of dentin-containing tooth GO:0042475 9.43 ODAM DLX2 DLX1 AMTN AMELX AMBN
20 positive regulation of enamel mineralization GO:0070175 9.4 ENAM AMTN
21 positive regulation of amacrine cell differentiation GO:1902871 9.37 DLX2 DLX1
22 cerebral cortex GABAergic interneuron fate commitment GO:0021893 9.32 DLX2 DLX1
23 biomineral tissue development GO:0031214 9.17 ODAM ENAM DSPP BGLAP AMTN AMELX

Molecular functions related to Dental Fluorosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 9.8 MMP9 MMP20 MMP2 ESR2 ESR1
2 metalloendopeptidase activity GO:0004222 9.5 MMP9 MMP20 MMP2
3 steroid hormone receptor activity GO:0003707 9.37 ESR2 ESR1
4 estrogen receptor activity GO:0030284 9.26 ESR2 ESR1
5 hydroxyapatite binding GO:0046848 9.16 BGLAP AMELX
6 estrogen response element binding GO:0034056 8.96 ESR2 ESR1
7 structural constituent of tooth enamel GO:0030345 8.8 ENAM AMELX AMBN

Sources for Dental Fluorosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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