Dental Pulp Calcification disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Dental Pulp Calcification

MalaCards integrated aliases for Dental Pulp Calcification:

Name: Dental Pulp Calcification ¹² ⁴⁴ ¹⁵ ⁷³

Pulpal Calcifications ¹²

Pulp Calcifications ¹²

Pulp Calcification ¹²

Dental Pulp Stone ⁷³

Classifications:

MalaCards categories:
Anatomical: Oral diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the digestive system

Diseases of oral cavity, salivary glands and jaws

Diseases of pulp and periapical tissues

Pulp degeneration

External Ids:

Disease Ontology ¹² DOID:5608

ICD10 ³³ K04.2

MeSH ⁴⁴ D003784

SNOMED-CT ⁶⁸ 57602001

UMLS ⁷³ C0011401 C1527284

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Summaries for Dental Pulp Calcification

MalaCards based summary : Dental Pulp Calcification, also known as pulpal calcifications, is related to dentin dysplasia, type ii and root resorption. An important gene associated with Dental Pulp Calcification is ENAM (Enamelin), and among its related pathways/superpathways are Degradation of the extracellular matrix and Elastic fibre formation. Related phenotypes are behavior/neurological and growth/size/body region

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Related Diseases for Dental Pulp Calcification

Diseases related to Dental Pulp Calcification via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 26)

#	Related Disease	Score	Top Affiliating Genes
1	dentin dysplasia, type ii	31.7	DSPP SPP1
2	root resorption	30.0	DSPP SPP1
3	marfan syndrome	29.6	FBN1 FBN2 TGFBR2
4	hypocalcified amelogenesis imperfecta	10.2	DSPP ENAM
5	teeth hard tissue disease	10.1	DSPP ENAM
6	pleural empyema	10.1	CTSC PDLIM7
7	marden-walker syndrome	10.1	FBN1 FBN2
8	dental caries	10.1	DSPP ENAM
9	amelogenesis imperfecta	10.0
10	amelogenesis imperfecta local hypoplastic	10.0
11	weill-marchesani syndrome	10.0	FBN1 FBN2
12	familial thoracic aortic aneurysm and dissection	10.0	FBN1 TGFBR2
13	dentin dysplasia	10.0	DSPP SPP1
14	char syndrome	10.0	FBN1 TGFBR2
15	loeys-dietz syndrome 3	10.0	FBN1 TGFBR2
16	loeys-dietz syndrome 1	9.9	FBN1 TGFBR2
17	dentinogenesis imperfecta	9.9	DSPP SPP1
18	aortic aneurysm, familial thoracic 1	9.9	FBN1 TGFBR2
19	aortic disease	9.9	FBN1 TGFBR2
20	hypercementosis	9.9	DSPP ENAM SPP1
21	loeys-dietz syndrome	9.8	FBN1 FBN2 TGFBR2
22	orthostatic intolerance	9.8	FBN1 FBN2
23	calcinosis	9.8	FBN1 SPP1
24	connective tissue disease	9.7	FBN1 FBN2 SPP1
25	aortic aneurysm	9.7	BGN FBN1 FBN2 TGFBR2
26	aortic valve disease 1	9.5	FBN1 FBN2 SPP1 TGFBR2

Graphical network of the top 20 diseases related to Dental Pulp Calcification:

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Symptoms & Phenotypes for Dental Pulp Calcification

MGI Mouse Phenotypes related to Dental Pulp Calcification:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	9.98	BGN CTSC ENAM FBN1 FBN2 SPP1
2	growth/size/body region	MP:0005378	9.97	BGN CTSC ENAM FBN1 FBN2 PDLIM7
3	homeostasis/metabolism	MP:0005376	9.92	BGN CTSC ENAM FBN1 FBN2 PDLIM7
4	craniofacial	MP:0005382	9.88	BGN ENAM FBN1 FBN2 SPP1 TGFBR2
5	immune system	MP:0005387	9.8	BGN CHIT1 CTSC FBN1 PDLIM7 SPP1
6	muscle	MP:0005369	9.55	BGN FBN1 FBN2 SPP1 TGFBR2
7	respiratory system	MP:0005388	9.35	FBN1 FBN2 PDLIM7 SPP1 TGFBR2
8	skeleton	MP:0005390	9.1	BGN ENAM FBN1 FBN2 SPP1 TGFBR2

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Drugs & Therapeutics for Dental Pulp Calcification

Search Clinical Trials , NIH Clinical Center for Dental Pulp Calcification

Cochrane evidence based reviews: dental pulp calcification

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Genetic Tests for Dental Pulp Calcification

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Anatomical Context for Dental Pulp Calcification

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Publications for Dental Pulp Calcification

Articles related to Dental Pulp Calcification:

#	Title	Authors	Year
1	Can dental pulp calcification predict the risk of ischemic cardiovascular disease? ( 24910654 )		2013
2	Can dental pulp calcification serve as a diagnostic marker for carotid artery calcification in patients with renal diseases? ( 20026712 )		2009
3	Prevalence of pulpal calcifications in the primary dentition of Hispanic children. ( 10860084 )	Milano M...Seybold SV	1999
4	Radiographic pulpal calcifications: normal or abnormal--a paradox. ( 1895038 )	Selden HS	1991
5	Pulpal calcifications in patients with coronary atherosclerosis. ( 3481572 )	Maranh?o de Moura AA...de Paiva JG	1987
6	Pulpal calcifications in primary teeth: a light microscope study. ( 3459852 )	Yaacob HB...Hamid JA	1986
7	Unusual pulpal calcifications--a case report. ( 10621589 )	Buller DL...Waters N	1976
8	Dental pulp calcification as a response to the methods of treatment. ( 4519735 )	Sayegh F.S....Reed J.A.	1973

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Genes for Dental Pulp Calcification

Genes related to Dental Pulp Calcification (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ENAM	Enamelin	Protein Coding	15.81	DISEASES inferred ¹⁵
2	CHIT1	Chitinase 1	Protein Coding	15.73	DISEASES inferred ¹⁵
3	DSPP	Dentin Sialophosphoprotein	Protein Coding	15.61	DISEASES inferred ¹⁵
4	PDLIM7	PDZ And LIM Domain 7	Protein Coding	15.49	DISEASES inferred ¹⁵
5	FBN2	Fibrillin 2	Protein Coding	15.38	DISEASES inferred ¹⁵
6	CTSC	Cathepsin C	Protein Coding	14.9	DISEASES inferred ¹⁵
7	FBN1	Fibrillin 1	Protein Coding	14.83	DISEASES inferred ¹⁵
8	TGFBR2	Transforming Growth Factor Beta Receptor 2	Protein Coding	14.64	DISEASES inferred ¹⁵
9	SPP1	Secreted Phosphoprotein 1	Protein Coding	13.92	DISEASES inferred ¹⁵
10	BGN	Biglycan	Protein Coding	13.55	DISEASES inferred ¹⁵

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Variations for Dental Pulp Calcification

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Expression for Dental Pulp Calcification

Search GEO for disease gene expression data for Dental Pulp Calcification.

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Pathways for Dental Pulp Calcification

Pathways related to Dental Pulp Calcification according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Degradation of the extracellular matrix ⁶⁶ Show member pathways Collagen degradation ⁶⁶ Extracellular matrix organization ⁶⁶	12.01	BGN DSPP FBN1 FBN2 SPP1
2	Elastic fibre formation ⁶⁶ Show member pathways Molecules associated with elastic fibres ⁶⁶	11.23	FBN1 FBN2
3	TGF-beta Receptor Signaling (WikiPathways) ¹	11.09	SPP1 TGFBR2
4	ECM proteoglycans ⁶⁶	11.01	BGN DSPP
5	Integrins in angiogenesis ¹	10.82	SPP1 TGFBR2
6	Hypothesized Pathways in Pathogenesis of Cardiovascular Disease ¹	10.2	FBN1 FBN2 TGFBR2

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GO Terms for Dental Pulp Calcification

Cellular components related to Dental Pulp Calcification according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	endoplasmic reticulum lumen	GO:0005788	9.56	CTSC ENAM FBN1 SPP1
2	extracellular region	GO:0005576	9.56	BGN CHIT1 CTSC DSPP ENAM FBN1
3	collagen-containing extracellular matrix	GO:0062023	9.46	BGN CTSC FBN1 FBN2
4	microfibril	GO:0001527	9.32	FBN1 FBN2
5	extracellular matrix	GO:0031012	9.02	BGN DSPP ENAM FBN1 FBN2

Biological processes related to Dental Pulp Calcification according to GeneCards Suite gene sharing:

(show all 13)

#	Name	GO ID	Score	Top Affiliating Genes
1	post-translational protein modification	GO:0043687	9.67	ENAM FBN1 SPP1
2	cellular protein metabolic process	GO:0044267	9.61	ENAM FBN1 SPP1
3	response to organic substance	GO:0010033	9.54	CTSC SPP1 TGFBR2
4	camera-type eye development	GO:0043010	9.52	FBN1 FBN2
5	response to mechanical stimulus	GO:0009612	9.51	DSPP TGFBR2
6	positive regulation of osteoblast differentiation	GO:0045669	9.48	FBN2 PDLIM7
7	embryo implantation	GO:0007566	9.46	SPP1 TGFBR2
8	response to steroid hormone	GO:0048545	9.4	SPP1 TGFBR2
9	embryonic eye morphogenesis	GO:0048048	9.32	FBN1 FBN2
10	positive regulation of enamel mineralization	GO:0070175	9.26	DSPP ENAM
11	sequestering of TGFbeta in extracellular matrix	GO:0035583	9.16	FBN1 FBN2
12	biomineral tissue development	GO:0031214	9.13	DSPP ENAM SPP1
13	extracellular matrix organization	GO:0030198	9.02	BGN DSPP FBN1 FBN2 SPP1

Molecular functions related to Dental Pulp Calcification according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular matrix binding	GO:0050840	9.26	BGN SPP1
2	glycosaminoglycan binding	GO:0005539	9.16	BGN TGFBR2
3	extracellular matrix constituent conferring elasticity	GO:0030023	8.96	FBN1 FBN2
4	extracellular matrix structural constituent	GO:0005201	8.92	BGN DSPP FBN1 FBN2

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Sources for Dental Pulp Calcification

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