MCID: DNT003
MIFTS: 28

Dental Pulp Calcification

Categories: Oral diseases

Aliases & Classifications for Dental Pulp Calcification

MalaCards integrated aliases for Dental Pulp Calcification:

Name: Dental Pulp Calcification 12 43 15 71
Pulpal Calcifications 12
Pulp Calcifications 12
Pulp Calcification 12
Dental Pulp Stone 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5608
MeSH 43 D003784
ICD10 32 K04.2
UMLS 71 C0011401 C1527284

Summaries for Dental Pulp Calcification

MalaCards based summary : Dental Pulp Calcification, also known as pulpal calcifications, is related to dentin dysplasia and amelogenesis imperfecta. An important gene associated with Dental Pulp Calcification is FAM20A (FAM20A Golgi Associated Secretory Pathway Pseudokinase). The drugs Chlorhexidine and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, bone marrow and bone, and related phenotypes are craniofacial and growth/size/body region

Related Diseases for Dental Pulp Calcification

Diseases related to Dental Pulp Calcification via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
# Related Disease Score Top Affiliating Genes
1 dentin dysplasia 30.0 ENAM DSPP
2 amelogenesis imperfecta 28.5 WDR72 FAM83H FAM20A ENAM DSPP CNNM4
3 dentin dysplasia, type ii 11.3
4 suppurative periapical periodontitis 10.3 FAM20A DSPP
5 hypoplastic amelogenesis imperfecta 10.2 FAM20A ENAM
6 tooth erosion 10.2 ENAM DSPP
7 root resorption 10.2
8 dental fluorosis 10.2 ENAM DSPP
9 amelogenesis imperfecta, type ia 10.0
10 atherosclerosis susceptibility 10.0
11 bruxism 10.0
12 amelogenesis imperfecta local hypoplastic 10.0
13 end stage renal disease 10.0
14 gingival fibromatosis 10.0 FAM20B FAM20A
15 conjunctival deposit 9.9 KL GALNT3
16 junctional epidermolysis bullosa 9.9 WDR72 ENAM
17 hypervitaminosis d 9.9 KL GALNT3
18 dental caries 9.9 ENAM DSPP
19 hypophosphatemic rickets, x-linked dominant 9.9 KL GALNT3
20 metaphyseal chondrodysplasia, jansen type 9.9 KL GALNT3
21 hypophosphatemic rickets, autosomal dominant 9.9 KL GALNT3
22 marfan syndrome 9.9
23 trigeminal neuralgia 9.9
24 salivary gland disease 9.9
25 tooth ankylosis 9.9
26 ankylosis 9.9
27 dentinogenesis imperfecta 9.9
28 hypercementosis 9.9 FAM83H ENAM DSPP
29 osteoglophonic dysplasia 9.9 KL GALNT3
30 phosphorus metabolism disease 9.8 KL GALNT3
31 arterial calcification of infancy 9.8 KL GALNT3
32 mineral metabolism disease 9.8 KL GALNT3
33 hyperphosphatemia 9.8 KL GALNT3
34 hypophosphatemia 9.8 KL DSPP
35 tooth agenesis 9.7 FAM20A ENAM DSPP CNNM4
36 dental abscess 9.7 KL GALNT3 DSPP
37 autosomal recessive hypophosphatemic rickets 9.7 KL GALNT3 DSPP
38 amelogenesis imperfecta, type iiia 9.7 WDR72 FAM83H ENAM
39 hyperostosis 9.4 KL GALNT3
40 familial tumoral calcinosis 9.3 SAMD9 KL GALNT3
41 calcinosis 9.3 SAMD9 KL GALNT3
42 tumoral calcinosis, hyperphosphatemic, familial, 1 9.3 SAMD9 KL GALNT3
43 jalili syndrome 9.2 WDR72 FAM83H FAM20A ENAM CNNM4
44 trichodentoosseous syndrome 9.0 WDR72 FAM83H FAM20A ENAM DSPP CNNM4
45 teeth hard tissue disease 9.0 WDR72 FAM83H FAM20A ENAM DSPP CNNM4

Graphical network of the top 20 diseases related to Dental Pulp Calcification:



Diseases related to Dental Pulp Calcification

Symptoms & Phenotypes for Dental Pulp Calcification

MGI Mouse Phenotypes related to Dental Pulp Calcification:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.87 CNNM4 ENAM FAM20A FAM83H GALNT3 KL
2 growth/size/body region MP:0005378 9.76 CNNM4 ENAM FAM20A FAM20B FAM83H GALNT3
3 digestive/alimentary MP:0005381 9.65 CNNM4 ENAM FAM20B GALNT3 KL
4 renal/urinary system MP:0005367 9.35 CNNM4 FAM20A GALNT3 KL WDR72
5 skeleton MP:0005390 9.23 CNNM4 ENAM FAM20A FAM20B FAM83H GALNT3

Drugs & Therapeutics for Dental Pulp Calcification

Drugs for Dental Pulp Calcification (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Chlorhexidine Approved, Vet_approved 55-56-1 9552079 2713
2 Pharmaceutical Solutions
3 Chlorhexidine gluconate
4 Disinfectants
5 Anti-Infective Agents, Local
6 Anti-Bacterial Agents
7 Dermatologic Agents
8 Anti-Infective Agents
9 Calcium, Dietary
10
Calcium Nutraceutical 7440-70-2 271

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Ozone Application in Stepwise Excavation Completed NCT03737201
2 154/2013 Grant for Mineral Trioxide Aggregate and Biodentine for Vital Pulp Therapy Active, not recruiting NCT03186690

Search NIH Clinical Center for Dental Pulp Calcification

Cochrane evidence based reviews: dental pulp calcification

Genetic Tests for Dental Pulp Calcification

Anatomical Context for Dental Pulp Calcification

MalaCards organs/tissues related to Dental Pulp Calcification:

40
Salivary Gland, Bone Marrow, Bone

Publications for Dental Pulp Calcification

Articles related to Dental Pulp Calcification:

(show all 42)
# Title Authors PMID Year
1
Removal of calcifications from distal canals of mandibular molars by a non-instrumentational cleaning system: A micro-CT study. 61
31605428 2020
2
Histological and immunohistochemical aspects of the atrophic dental pulp modifications of abutment teeth. 61
31912101 2019
3
Evaluation of the relationship between sleep bruxism and pulpal calcifications in young women: A clinico-radiological study. 61
30607352 2018
4
A histological and radiographic study of pulpal calcification in periodontally involved teeth in a Taiwanese population. 61
30895005 2016
5
Pulp Obliteration in a Patient with Sclerodermatous Chronic Graft-versus-Host Disease. 61
26906241 2016
6
Advanced glycation end products increase expression of S100A8 and A9 via RAGE-MAPK in rat dental pulp cells. 61
25098709 2015
7
A Rare Co-occurrence of Amelogenesis Imperfecta (AI) and Various Non-Enamel Manifestations In Siblings-Report of Two Cases. 61
24596797 2014
8
Potential correlation between statins and pulp chamber calcification. 61
23953283 2013
9
Can dental pulp calcification predict the risk of ischemic cardiovascular disease? 61
24910654 2013
10
Multiple unerupted teeth with amelogenesis imperfecta in siblings. 61
22655284 2012
11
Association of pulp stones with coronary artery stenosis. 61
22320071 2011
12
Oral and radiographic findings in patients undergoing continuous ambulatory peritoneal dialysis. 61
22043576 2011
13
Long-term radiologic pulp evaluation after partial pulpotomy in young permanent molars. 61
21716982 2011
14
Evaluation of the interaction between calcifying nanoparticles and human dental pulp cells: a preliminary investigation. 61
21289977 2010
15
High glucose levels increase osteopontin production and pathologic calcification in rat dental pulp tissues. 61
20478457 2010
16
Can dental pulp calcification serve as a diagnostic marker for carotid artery calcification in patients with renal diseases? 61
20026712 2009
17
Prevalence of carotid and pulp calcifications: a correlation using digital panoramic radiographs. 61
20033616 2009
18
[A retrospective study of pulp healing after luxation injuries]. 61
19087600 2008
19
Enamel dysplasia with hamartomatous atypical follicular hyperplasia: review of the literature and report of a case. 61
18561808 2008
20
Clinical, radiographic and histological analysis of the effects of mineral trioxide aggregate used in direct pulp capping and pulpotomies of primary teeth. 61
17256303 2006
21
Multiple pulp stones and shortened roots of unknown etiology. 61
16731378 2006
22
Dental abnormalities in children preparing for pediatric bone marrow transplantation. 61
16184186 2005
23
Unusual manifestations in X-linked amelogenesis imperfecta. 61
12924992 2003
24
Pulp biology: progress during the past 25 years. 61
12772964 2003
25
Hereditary pattern for dentinal dysplasia type Id: a case report. 61
12193893 2002
26
Prevalence of pulpal calcifications in the primary dentition of Hispanic children. 61
10860084 1999
27
Pulp stones throughout the dentition of monozygotic twins: a case report. 61
10397671 1999
28
Dentin dysplasia, type II: report of 2 new families and review of the literature. 61
10397672 1999
29
Diagnostic radiographic findings and symptom-free teeth. 61
8006564 1994
30
Radiographic pulpal calcifications: normal or abnormal--a paradox. 61
1895038 1991
31
[The aging of the human pulp-dentin organ]. 61
1853181 1991
32
Comparison of the radiographic appearance of root canal size to its actual diameter. 61
2084209 1990
33
Pulpal calcifications in patients with coronary atherosclerosis. 61
3481572 1987
34
Traumatically injured primary incisors: a clinical and histological study. 61
3478370 1987
35
Hereditary amelogenesis imperfecta. I. Oral health in children. 61
3466378 1986
36
Pulpal calcifications in primary teeth: a light microscope study. 61
3459852 1986
37
Dental abnormalities in aging sand rats (Psammomys obesus). 61
6432980 1984
38
Tangier disease with oral abnormalities. 61
6409822 1983
39
[Pulpal calcifications related to cases of generalized periodontal diseases]. 61
351744 1978
40
Unusual pulpal calcifications--a case report. 61
10621589 1976
41
Dental pulp calcification as a response to the methods of treatment. 61
4519735 1973
42
[Dental pulp calcification]. 61
5276014 1970

Variations for Dental Pulp Calcification

Expression for Dental Pulp Calcification

Search GEO for disease gene expression data for Dental Pulp Calcification.

Pathways for Dental Pulp Calcification

GO Terms for Dental Pulp Calcification

Biological processes related to Dental Pulp Calcification according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 fibroblast growth factor receptor signaling pathway GO:0008543 9.26 KL GALNT3
2 calcium ion homeostasis GO:0055074 9.16 KL FAM20A
3 enamel mineralization GO:0070166 9.13 WDR72 FAM20A CNNM4
4 biomineral tissue development GO:0031214 9.1 WDR72 FAM83H FAM20A ENAM DSPP CNNM4

Molecular functions related to Dental Pulp Calcification according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphotransferase activity, alcohol group as acceptor GO:0016773 8.62 FAM20B FAM20A

Sources for Dental Pulp Calcification

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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