Dental Pulp Calcification disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Dental Pulp Calcification

MalaCards integrated aliases for Dental Pulp Calcification:

Name: Dental Pulp Calcification ¹² ⁴⁴ ¹⁵ ⁷³

Pulpal Calcifications ¹²

Pulp Calcifications ¹²

Pulp Calcification ¹²

Dental Pulp Stone ⁷³

Classifications:

MalaCards categories:
Anatomical: Oral diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the digestive system

Diseases of oral cavity, salivary glands and jaws

Diseases of pulp and periapical tissues

Pulp degeneration

External Ids:

Disease Ontology ¹² DOID:5608

ICD10 ³³ K04.2

MeSH ⁴⁴ D003784

SNOMED-CT ⁶⁸ 57602001

UMLS ⁷³ C0011401 C1527284

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Summaries for Dental Pulp Calcification

MalaCards based summary : Dental Pulp Calcification, also known as pulpal calcifications, is related to dentin dysplasia, type ii and root resorption. An important gene associated with Dental Pulp Calcification is CHIT1 (Chitinase 1), and among its related pathways/superpathways are Degradation of the extracellular matrix and Elastic fibre formation. Related phenotypes are behavior/neurological and growth/size/body region

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Related Diseases for Dental Pulp Calcification

Diseases related to Dental Pulp Calcification via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 26)

#	Related Disease	Score	Top Affiliating Genes
1	dentin dysplasia, type ii	31.4	DSPP SPP1
2	root resorption	29.6	DSPP SPP1
3	marfan syndrome	28.8	FBN1 FBN2 TGFBR2
4	hypocalcified amelogenesis imperfecta	10.4	DSPP ENAM
5	teeth hard tissue disease	10.4	DSPP ENAM
6	dental caries	10.2	DSPP ENAM
7	marden-walker syndrome	10.1	FBN1 FBN2
8	weill-marchesani syndrome	10.1	FBN1 FBN2
9	popliteal pterygium syndrome	10.0	FBN1 FBN2
10	familial thoracic aortic aneurysm and dissection	10.0	FBN1 TGFBR2
11	char syndrome	9.9	FBN1 TGFBR2
12	amelogenesis imperfecta	9.9
13	amelogenesis imperfecta local hypoplastic	9.9
14	dentin dysplasia	9.9	DSPP SPP1
15	aortic aneurysm, familial thoracic 1	9.8	FBN1 TGFBR2
16	dentinogenesis imperfecta	9.8	DSPP SPP1
17	aortic disease	9.7	FBN1 TGFBR2
18	orthostatic intolerance	9.7	FBN1 FBN2
19	hypercementosis	9.5	DSPP ENAM SPP1
20	aortic valve disease 1	9.5	FBN1 SPP1
21	loeys-dietz syndrome	9.5	FBN1 FBN2 TGFBR2
22	calcinosis	9.3	FBN1 SPP1
23	connective tissue disease	9.2	FBN1 FBN2 SPP1
24	aortic valve disease 2	9.0	FBN1 SPP1
25	aneurysm	8.9	BGN FBN1 FBN2 TGFBR2
26	aortic aneurysm	8.8	BGN FBN1 FBN2 TGFBR2

Graphical network of the top 20 diseases related to Dental Pulp Calcification:

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Symptoms & Phenotypes for Dental Pulp Calcification

MGI Mouse Phenotypes related to Dental Pulp Calcification:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	9.88	TGFBR2 BGN ENAM FBN1 FBN2 SPP1
2	growth/size/body region	MP:0005378	9.87	BGN ENAM FBN1 FBN2 PDLIM7 SPP1
3	craniofacial	MP:0005382	9.77	BGN ENAM FBN1 SPP1 TGFBR2
4	immune system	MP:0005387	9.73	BGN CHIT1 FBN1 PDLIM7 SPP1 TGFBR2
5	muscle	MP:0005369	9.55	BGN FBN1 FBN2 SPP1 TGFBR2
6	respiratory system	MP:0005388	9.35	FBN1 FBN2 PDLIM7 SPP1 TGFBR2
7	skeleton	MP:0005390	9.1	BGN ENAM FBN1 FBN2 SPP1 TGFBR2

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Drugs & Therapeutics for Dental Pulp Calcification

Search Clinical Trials , NIH Clinical Center for Dental Pulp Calcification

Cochrane evidence based reviews: dental pulp calcification

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Genetic Tests for Dental Pulp Calcification

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Anatomical Context for Dental Pulp Calcification

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Publications for Dental Pulp Calcification

Articles related to Dental Pulp Calcification:

#	Title	Authors	Year
1	Can dental pulp calcification predict the risk of ischemic cardiovascular disease? ( 24910654 )	Khojastepour L....Rahimi E.	2013
2	Can dental pulp calcification serve as a diagnostic marker for carotid artery calcification in patients with renal diseases? ( 20026712 )	Kansu O....GenAstoy G.	2009
3	Dental pulp calcification as a response to the methods of treatment. ( 4519735 )	Sayegh F.S....Reed J.A.	1973

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Genes for Dental Pulp Calcification

Genes related to Dental Pulp Calcification (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CHIT1	Chitinase 1	Protein Coding	15.9	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	ENAM	Enamelin	Protein Coding	15.88	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	DSPP	Dentin Sialophosphoprotein	Protein Coding	15.74	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	PDLIM7	PDZ And LIM Domain 7	Protein Coding	15.65	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	FBN2	Fibrillin 2	Protein Coding	15.54	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	FBN1	Fibrillin 1	Protein Coding	14.94	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	TGFBR2	Transforming Growth Factor Beta Receptor 2	Protein Coding	14.83	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	SPP1	Secreted Phosphoprotein 1	Protein Coding	14.09	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	BGN	Biglycan	Protein Coding	13.66	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)

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Variations for Dental Pulp Calcification

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Expression for Dental Pulp Calcification

Search GEO for disease gene expression data for Dental Pulp Calcification.

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Pathways for Dental Pulp Calcification

Pathways related to Dental Pulp Calcification according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Degradation of the extracellular matrix ⁶⁶ Show member pathways Collagen degradation ⁶⁶ Extracellular matrix organization ⁶⁶	12.01	BGN DSPP FBN1 FBN2 SPP1
2	Elastic fibre formation ⁶⁶ Show member pathways Molecules associated with elastic fibres ⁶⁶	11.23	FBN1 FBN2
3	TGF-beta Receptor Signaling (WikiPathways) ¹	11.09	SPP1 TGFBR2
4	ECM proteoglycans ⁶⁶	11.01	BGN DSPP
5	Integrins in angiogenesis ¹	10.82	SPP1 TGFBR2
6	Hypothesized Pathways in Pathogenesis of Cardiovascular Disease ¹	10.2	FBN1 FBN2 TGFBR2

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GO Terms for Dental Pulp Calcification

Cellular components related to Dental Pulp Calcification according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	endoplasmic reticulum lumen	GO:0005788	9.43	ENAM FBN1 SPP1
2	extracellular matrix	GO:0031012	9.33	BGN FBN1 FBN2
3	extracellular region	GO:0005576	9.17	BGN CHIT1 DSPP ENAM FBN1 FBN2
4	microfibril	GO:0001527	8.96	FBN1 FBN2

Biological processes related to Dental Pulp Calcification according to GeneCards Suite gene sharing:

(show all 12)

#	Name	GO ID	Score	Top Affiliating Genes
1	post-translational protein modification	GO:0043687	9.67	ENAM FBN1 SPP1
2	cellular protein metabolic process	GO:0044267	9.58	ENAM FBN1 SPP1
3	camera-type eye development	GO:0043010	9.51	FBN1 FBN2
4	extracellular matrix disassembly	GO:0022617	9.5	FBN1 FBN2 SPP1
5	positive regulation of osteoblast differentiation	GO:0045669	9.48	FBN2 PDLIM7
6	embryo implantation	GO:0007566	9.46	SPP1 TGFBR2
7	response to steroid hormone	GO:0048545	9.43	SPP1 TGFBR2
8	embryonic eye morphogenesis	GO:0048048	9.37	FBN1 FBN2
9	regulation of cellular response to growth factor stimulus	GO:0090287	9.26	FBN1 FBN2
10	sequestering of TGFbeta in extracellular matrix	GO:0035583	9.16	FBN1 FBN2
11	biomineral tissue development	GO:0031214	9.13	DSPP ENAM SPP1
12	extracellular matrix organization	GO:0030198	9.02	BGN DSPP FBN1 FBN2 SPP1

Molecular functions related to Dental Pulp Calcification according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular matrix binding	GO:0050840	9.26	BGN SPP1
2	glycosaminoglycan binding	GO:0005539	9.16	BGN TGFBR2
3	extracellular matrix constituent conferring elasticity	GO:0030023	8.96	FBN1 FBN2
4	extracellular matrix structural constituent	GO:0005201	8.92	BGN DSPP FBN1 FBN2

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Sources for Dental Pulp Calcification

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

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¹⁶ DrugBank

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¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia