MCID: DNT003
MIFTS: 25

Dental Pulp Calcification

Categories: Oral diseases

Aliases & Classifications for Dental Pulp Calcification

MalaCards integrated aliases for Dental Pulp Calcification:

Name: Dental Pulp Calcification 12 44 15 70
Pulp Calcifications 12 6
Pulpal Calcifications 12
Pulp Calcification 12
Dental Pulp Stone 70

Classifications:



External Ids:

Disease Ontology 12 DOID:5608
MeSH 44 D003784
SNOMED-CT 67 57602001
ICD10 32 K04.2
UMLS 70 C0011401 C1527284

Summaries for Dental Pulp Calcification

MalaCards based summary : Dental Pulp Calcification, also known as pulp calcifications, is related to dentin dysplasia and dentin dysplasia, type ii. An important gene associated with Dental Pulp Calcification is DSPP (Dentin Sialophosphoprotein). Affiliated tissues include salivary gland, and related phenotypes are craniofacial and skeleton

Related Diseases for Dental Pulp Calcification

Diseases related to Dental Pulp Calcification via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
# Related Disease Score Top Affiliating Genes
1 dentin dysplasia 29.5 ENAM DSPP AMELX
2 dentin dysplasia, type ii 11.1
3 hypoplastic amelogenesis imperfecta 10.1 FAM20A ENAM
4 end stage renal disease 10.0
5 root caries 10.0 DSPP AMELX
6 dental pulp necrosis 10.0 DSPP AMELX
7 root resorption 10.0
8 bruxism 10.0
9 dentine erosion 10.0 ENAM AMELX
10 amelogenesis imperfecta, type ic 10.0 ENAM AMELX
11 dental pulp disease 9.9 DSPP AMELX
12 enamel caries 9.9 ENAM AMELX
13 amelogenesis imperfecta, type ib 9.9 ENAM AMELX
14 tooth resorption 9.9 DSPP AMELX
15 papillary craniopharyngioma 9.9 ENAM AMELX
16 dental abscess 9.9 GALNT3 DSPP
17 amelogenesis imperfecta, type ig 9.9 FAM20B FAM20A
18 marfan syndrome 9.9
19 salivary gland disease 9.9
20 immunodeficiency 9 9.9 FAM83H FAM20A CNNM4
21 trigeminal neuralgia 9.9
22 tooth ankylosis 9.9
23 ankylosis 9.9
24 dentinogenesis imperfecta 9.9
25 pulp degeneration 9.8 ENAM DSPP AMELX
26 autosomal recessive hypophosphatemic rickets 9.8 GALNT3 DSPP
27 tooth erosion 9.8 ENAM DSPP AMELX
28 dental fluorosis 9.8 ENAM DSPP AMELX
29 dental caries 9.8 ENAM DSPP AMELX
30 familial tumoral calcinosis 9.8 SAMD9 GALNT3
31 calcinosis 9.7 SAMD9 GALNT3
32 amelogenesis imperfecta, type iiia 9.7 FAM83H ENAM AMELX
33 tumoral calcinosis, hyperphosphatemic, familial, 1 9.7 SAMD9 GALNT3
34 jalili syndrome 9.6 FAM83H FAM20A ENAM CNNM4
35 tooth disease 9.6 ENAM DSPP AMELX
36 hypophosphatemic rickets, x-linked dominant 9.6 GALNT3 DSPP
37 hypercementosis 9.5 FAM83H ENAM DSPP AMELX
38 tooth agenesis 9.4 FAM20A ENAM DSPP CNNM4 AMELX
39 trichodentoosseous syndrome 9.1 FAM83H FAM20A ENAM DSPP CNNM4 AMELX
40 teeth hard tissue disease 9.1 FAM83H FAM20A ENAM DSPP CNNM4 AMELX
41 amelogenesis imperfecta 8.9 FAM83H FAM20B FAM20A ENAM DSPP CNNM4

Graphical network of the top 20 diseases related to Dental Pulp Calcification:



Diseases related to Dental Pulp Calcification

Symptoms & Phenotypes for Dental Pulp Calcification

MGI Mouse Phenotypes related to Dental Pulp Calcification:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.35 CNNM4 ENAM FAM20A FAM83H GALNT3
2 skeleton MP:0005390 9.1 CNNM4 ENAM FAM20A FAM20B FAM83H GALNT3

Drugs & Therapeutics for Dental Pulp Calcification

Search Clinical Trials , NIH Clinical Center for Dental Pulp Calcification

Cochrane evidence based reviews: dental pulp calcification

Genetic Tests for Dental Pulp Calcification

Anatomical Context for Dental Pulp Calcification

MalaCards organs/tissues related to Dental Pulp Calcification:

40
Salivary Gland

Publications for Dental Pulp Calcification

Articles related to Dental Pulp Calcification:

(show top 50) (show all 53)
# Title Authors PMID Year
1
The dentin phosphoprotein repeat region and inherited defects of dentin. 6
26788535 2016
2
Dentin phosphoprotein frameshift mutations in hereditary dentin disorders and their variation patterns in normal human population. 6
18456718 2008
3
Mutation of the signal peptide region of the bicistronic gene DSPP affects translocation to the endoplasmic reticulum and results in defective dentine biomineralization. 6
12354781 2002
4
Dental pulp calcifications in prehistoric and historical skeletal remains. 61
33515689 2021
5
Analysis on the predictive value of different variables in pulp stones appearance frequency and its pulpal response to cold stimuli. 61
32778987 2021
6
Effects of advanced glycation end products on dental pulp calcification. 61
33539626 2021
7
Evaluation of dentinogenesis inducer biomaterials: an in vivo study. 61
31800871 2020
8
Pulp Stones as Risk Predictors for Coronary Artery Disease. 61
32089807 2020
9
Endodontic treatment of a hypertaurodontic mandibular left second molar in a patient with many taurodonts combined with multiple pulp stones. 61
30113740 2019
10
Pulp pathosis associated with ancient Maya dental inlays. 61
30144666 2018
11
Guided Endodontic Access in Maxillary Molars Using Cone-beam Computed Tomography and Computer-aided Design/Computer-aided Manufacturing System: A Case Report. 61
29571910 2018
12
Age-related morphological, histological and functional changes in teeth. 61
28032898 2017
13
Pulp Obliteration in a Patient with Sclerodermatous Chronic Graft-versus-Host Disease. 61
26906241 2016
14
Advanced glycation end products increase expression of S100A8 and A9 via RAGE-MAPK in rat dental pulp cells. 61
25098709 2015
15
The osseous and dental changes of patients with chronic renal failure by CBCT. 61
25629722 2015
16
The relationship between pulp calcifications and salivary gland calcifications. 61
25674311 2014
17
Histologic evaluation of human pulp tissue after orthodontic intrusion. 61
25115659 2014
18
Can dental pulp calcification predict the risk of ischemic cardiovascular disease? 61
24910654 2013
19
Potential correlation between statins and pulp chamber calcification. 61
23953283 2013
20
Previously undescribed pulpal and periodontal ligament calcifications in systemic sclerosis: a case report. 61
23332508 2013
21
Idiopathic dental pulp calcifications in a tertiary care setting in South India. 61
23349577 2013
22
A biochemical and histopathological evaluation of generalized pulp calcification in young permanent teeth. 61
22842270 2012
23
Association of pulp stones with coronary artery stenosis. 61
22320071 2011
24
Orthodontic treatment in a patient with sickle cell anemia. 61
22051492 2011
25
Oral and radiographic findings in patients undergoing continuous ambulatory peritoneal dialysis. 61
22043576 2011
26
Pulp calcification in traumatized primary teeth: prevalence and associated factors. 61
22046696 2011
27
Evaluation of the interaction between calcifying nanoparticles and human dental pulp cells: a preliminary investigation. 61
21289977 2010
28
High glucose levels increase osteopontin production and pathologic calcification in rat dental pulp tissues. 61
20478457 2010
29
Can dental pulp calcification serve as a diagnostic marker for carotid artery calcification in patients with renal diseases? 61
20026712 2009
30
Prevalence of carotid and pulp calcifications: a correlation using digital panoramic radiographs. 61
20033616 2009
31
Long term histological response of hemisectioned exposed primary pulps. An in vivo study. 61
19953804 2009
32
Prevalence of pulp calcifications in patients with Marfan syndrome. 61
18805711 2008
33
A clinical and histological study of dental defects in a 10-year-old girl with pseudoxanthoma elasticum and amelogenesis imperfecta. 61
18298544 2008
34
[A retrospective study of pulp healing after luxation injuries]. 61
19087600 2008
35
Pulp stones: a review. 61
18422587 2008
36
Pulp calcifications in traumatized primary incisors. A morphological and inductive analysis study. 61
9249185 1997
37
Effect on human teeth of renal transplantation: a postmortem study. 61
8362197 1993
38
Microradiography and light microscopy of mineralization in the pulp of undemineralized human primary molars. 61
8445542 1993
39
Pseudohypoparathyroidism: case report. 61
1881816 1991
40
Pulp calcifications in primary teeth. 61
2074414 1990
41
Pulp calcifications in primary teeth. 61
2374084 1990
42
[The occurrence of denticles in the craniums of Norwegian Samis (Lapps)]. 61
2623598 1989
43
[Ultrastructure of microcalcifications of the pulp mesenchyme of human deciduous teeth]. 61
2924012 1989
44
Transmission electron microscopy of the morphological relationship between fibroblasts and pulp calcifications in temporary teeth. 61
3135373 1988
45
[Pulp calcifications]. 61
3333822 1987
46
Visualization of the human periodontium using serial thin section contact radiography. 61
3858504 1985
47
[Crystallographic and ultramicroscopic (SEM) study of pulp calcifications: preliminary results]. 61
6947838 1981
48
Dental pulp calcification as a response to the methods of treatment. 61
4519735 1973
49
[Dental pulp calcification]. 61
5276014 1970
50
[Pulp calcifications]. 61
5265903 1969

Variations for Dental Pulp Calcification

ClinVar genetic disease variations for Dental Pulp Calcification:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 DSPP NM_014208.3(DSPP):c.16T>G (p.Tyr6Asp) SNV Pathogenic 16857 rs121912988 GRCh37: 4:88532076-88532076
GRCh38: 4:87610924-87610924
2 DSPP NM_014208.3(DSPP):c.2040del (p.Ser680fs) Deletion Pathogenic 16860 rs1560478758 GRCh37: 4:88535854-88535854
GRCh38: 4:87614702-87614702
3 DSPP NM_014208.3(DSPP):c.3135del (p.Ser1045fs) Deletion Likely pathogenic 548664 rs1553904372 GRCh37: 4:88536949-88536949
GRCh38: 4:87615797-87615797
4 DSPP NM_014208.3(DSPP):c.3504_3508dup (p.Asp1170fs) Duplication Likely pathogenic 548665 rs1553904512 GRCh37: 4:88537316-88537317
GRCh38: 4:87616164-87616165

Expression for Dental Pulp Calcification

Search GEO for disease gene expression data for Dental Pulp Calcification.

Pathways for Dental Pulp Calcification

GO Terms for Dental Pulp Calcification

Cellular components related to Dental Pulp Calcification according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 8.8 ENAM DSPP AMELX

Biological processes related to Dental Pulp Calcification according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enamel mineralization GO:0070166 9.13 FAM20A CNNM4 AMELX
2 biomineral tissue development GO:0031214 9.1 FAM83H FAM20A ENAM DSPP CNNM4 AMELX

Molecular functions related to Dental Pulp Calcification according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphotransferase activity, alcohol group as acceptor GO:0016773 8.96 FAM20B FAM20A
2 structural constituent of tooth enamel GO:0030345 8.62 ENAM AMELX

Sources for Dental Pulp Calcification

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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