Aliases & Classifications for Dental Pulp Disease

MalaCards integrated aliases for Dental Pulp Disease:

Name: Dental Pulp Disease 12 15
Dental Pulp Diseases 44 73
Disorder of Pulp of Tooth 12
Dental Pulp Disorder 12
Pulp Disorder 12


External Ids:

Disease Ontology 12 DOID:5330
MeSH 44 D003788
NCIt 50 C34530
SNOMED-CT 68 57203004
UMLS 73 C0011405

Summaries for Dental Pulp Disease

MalaCards based summary : Dental Pulp Disease, also known as dental pulp diseases, is related to paroxysmal extreme pain disorder and recurrent corneal erosion, and has symptoms including toothache An important gene associated with Dental Pulp Disease is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are Bacterial infections in CF airways and Spinal Cord Injury. The drugs Lidocaine and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include testes and bone, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 76 The pulp, or endodontium is the part in the center of a tooth made up of living connective tissue and... more...

Related Diseases for Dental Pulp Disease

Diseases related to Dental Pulp Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 132)
# Related Disease Score Top Affiliating Genes
1 paroxysmal extreme pain disorder 10.7 SCN11A TRPV1
2 recurrent corneal erosion 10.6 CXCL8 IL1B
3 diverticulitis of colon 10.6 NPS TRPV1
4 bagassosis 10.6 CXCL8 IL1B
5 peptic esophagitis 10.6 CXCL8 IL1B
6 funisitis 10.6 CXCL8 IL1B
7 periapical periodontitis 10.6 DSPP IL1B SASS6
8 opisthorchiasis 10.5 CXCL8 IL1B
9 aspiration pneumonia 10.5 TAC1 TRPV1
10 retinitis pigmentosa 68 10.5 NPS TAC1
11 epicondylitis 10.5 NPS TAC1
12 vaginal disease 10.4 CXCL8 DSPP IL1B
13 endometrial disease 10.4 CXCL8 DSPP IL1B
14 stomach disease 10.4 CXCL8 IL1B TRPV1
15 esophagitis 10.4 CXCL8 IL1B TRPV1
16 systemic onset juvenile idiopathic arthritis 10.4 IL1B TNF
17 staphylococcal toxic shock syndrome 10.4 IL1B TNF
18 autoimmune myocarditis 10.4 IL1B TNF
19 gastroesophageal reflux 10.4 CXCL8 IL1B TRPV1
20 kashin-beck disease 10.4 IL1B TNF
21 somatoform disorder 10.4 IL1B TAC1 TRPV1
22 mononeuropathy 10.4 TAC1 TRPV1
23 trigeminal nerve disease 10.4 SCN11A TAC1 TRPV1
24 vulvar vestibulitis syndrome 10.3 IL1B TNF
25 burns 10.3 IL1B TNF
26 laryngitis 10.3 IL1B TNF
27 cerebral artery occlusion 10.3 IL1B TNF
28 aplasia of lacrimal and salivary glands 10.3 DSPP TAC1
29 retinitis pigmentosa 60 10.3 IL1B TNF
30 irritant dermatitis 10.3 IL1B TNF
31 acute vascular insufficiency of intestine 10.3 IL1B TNF
32 actinic prurigo 10.3 IL1B TNF
33 tungiasis 10.2 CXCL8 TNF
34 streptococcal toxic-shock syndrome 10.2 CXCL8 TNF
35 interstitial cystitis 10.2 CXCL8 TAC1 TRPV1
36 poems syndrome 10.2 IL1B TNF
37 sebaceous gland disease 10.2 CXCL8 NPS
38 central nervous system vasculitis 10.2 IL1B TNF
39 trichuriasis 10.2 CXCL8 TNF
40 lacrimal apparatus disease 10.2 IL1B TNF TRPV1
41 osteosclerotic myeloma 10.2 IL1B TNF
42 stachybotrys chartarum 10.1 IL1B TNF
43 hypersensitivity reaction disease 10.1 IL1B TNF TRPV1
44 mouth disease 10.1 IL1B TNF TRPV1
45 glucose metabolism disease 10.1 IL1B TNF TRPV1
46 arteries, anomalies of 10.1 IL1B TNF TRPV1
47 clonorchiasis 10.1 CXCL8 TNF
48 immune system disease 10.1 IL1B TNF TRPV1
49 acquired metabolic disease 10.1 IL1B TNF TRPV1
50 vaginitis 10.1 CXCL8 IL1B

Graphical network of the top 20 diseases related to Dental Pulp Disease:

Diseases related to Dental Pulp Disease

Symptoms & Phenotypes for Dental Pulp Disease

UMLS symptoms related to Dental Pulp Disease:


GenomeRNAi Phenotypes related to Dental Pulp Disease according to GeneCards Suite gene sharing:

# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.36 IL1B
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-14 9.36 IL1B METTL14 SCN11A
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.36 IL1B METTL14
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-187 9.36 SCN11A
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.36 SCN11A
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.36 METTL14
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.36 METTL14
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 9.36 METTL14

Drugs & Therapeutics for Dental Pulp Disease

Drugs for Dental Pulp Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 142)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 137-58-6 3676
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
Tramadol Approved, Investigational Phase 4,Phase 1,Phase 2 27203-92-5 33741
Ketoprofen Approved, Vet_approved Phase 4 22071-15-4 3825
Prednisolone Approved, Vet_approved Phase 4,Phase 3 50-24-8 5755
Ibuprofen Approved Phase 4,Phase 2,Not Applicable 15687-27-1 3672
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 51-43-4 5816
Methamphetamine Approved, Illicit Phase 4 537-46-2 10836
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3 83-43-2 6741
Racepinephrine Approved Phase 4,Phase 3,Phase 2,Not Applicable 329-65-7 838
Ephedrine Approved Phase 4 299-42-3 9294
Pseudoephedrine Approved Phase 4 90-82-4 7028
Phenylephrine Approved Phase 4 59-42-7 6041
Oxymetazoline Approved, Investigational Phase 4 1491-59-4 4636
Tetracaine Approved, Vet_approved Phase 4 94-24-6 5411
Bismuth Phase 4,Phase 2,Phase 3 7440-69-9 16682734 105143
18 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
19 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable
20 Bone Density Conservation Agents Phase 4,Phase 2,Phase 3,Not Applicable
21 Calcium, Dietary Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
22 Prednisolone acetate Phase 4,Phase 3
23 Analgesics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
24 glucocorticoids Phase 4,Phase 3
25 Respiratory System Agents Phase 4,Phase 3,Phase 2,Not Applicable
26 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
27 Methylprednisolone acetate Phase 4,Phase 3
28 Methylprednisolone Hemisuccinate Phase 4,Phase 3
29 Adrenergic Agents Phase 4,Phase 3,Phase 2,Not Applicable
30 Central Nervous System Stimulants Phase 4
31 Adrenergic Agonists Phase 4,Phase 3,Phase 2,Not Applicable
32 Adrenergic alpha-Agonists Phase 4,Phase 3,Phase 2,Not Applicable
33 Adrenergic beta-Agonists Phase 4,Phase 3,Phase 2,Not Applicable
34 Mydriatics Phase 4,Phase 3,Phase 2,Not Applicable
35 Gastrointestinal Agents Phase 4,Phase 3
36 Narcotics Phase 4,Phase 2,Phase 1
37 Sodium Channel Blockers Phase 4,Phase 3,Phase 2,Not Applicable
38 Neuroprotective Agents Phase 4,Phase 3
39 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Not Applicable
40 Cyclooxygenase Inhibitors Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
41 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
42 Analgesics, Opioid Phase 4,Phase 2,Phase 1
43 Neurotransmitter Uptake Inhibitors Phase 4
44 Anesthetics Phase 4,Phase 2,Phase 3,Not Applicable
45 Hormone Antagonists Phase 4,Phase 3
46 Anesthetics, Local Phase 4,Phase 3,Phase 2,Not Applicable
47 Dexketoprofen trometamol Phase 4
48 Hormones Phase 4,Phase 3
49 Diuretics, Potassium Sparing Phase 4,Phase 3,Phase 2,Not Applicable
50 Dopamine Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 153)
# Name Status NCT ID Phase Drugs
1 Success and Color Stability of MTA Pulpotomized Primary Molars: an RCT Unknown status NCT02702505 Phase 4
2 Success Rate Evaluation of Miniature Pulpotomy With MTA in Primary Molars Unknown status NCT02286648 Phase 4 Formocresol;Mineral Trioxide Aggregate
3 Postoperative Pain in Single-visit and Multiple-visit Retreatment Cases Completed NCT03042377 Phase 4 Multiple-Visit-"Calcium Hydroxide";Multiple-Visit-"Corticosteroid Paste";Multiple-Visit-"Antibiotic Paste"
4 Efficacy Study of Articaine Versus Lidocaine as Supplemental Infiltration in Inflamed Molars Completed NCT01496846 Phase 4 IANB Articaine;SUP Articaine;SUP Lidocaine
5 Oral Glucocorticoids Effect on Post Endodontic Pain Completed NCT02819648 Phase 4 Prednisolone
6 Mepivacaine-Tramadol on the Success of Inferior Alveolar Nerve Block in Symptomatic Irreversible Pulpitis Completed NCT02110966 Phase 4 Mepivacaine;Mepivacaine plus Tramadol
7 Dexketoprofen Trometamol in Postoperative Endodontic Pain Completed NCT02086097 Phase 4 Dexketoprofen trometamol;Ibuprofen;PLACEBO
8 Anesthetic Efficacy in Irreversible Pulpitis Completed NCT02054767 Phase 4 Intervention: inferior alveolar nerve block injection
9 Anesthetic Efficacy of Articaine and Lidocaine in Lower Molars With Irreversible Pulpits Completed NCT01912755 Phase 4 4% articaine with 1:100,000 epinephrine;2% lidocaine with 1:100,000 epinephrine
10 Prefabricated Endodontic Posts: Glass Fiber Versus Titanium - A Randomized Controlled Pilot- Trial Completed NCT01520766 Phase 4
11 Efficiency of Triple Antibiotic Paste, Ciprofloxacin/Propolis, Ciprofloxacin/Metronidazole, Propolis/Metronidazole Combinations on Revascularization Process of Immature Necrotic Maxillary Incisors of Patients 8-18 Years Old. Completed NCT03533231 Phase 4
12 Comparison of Two Dental Techniques Used to Treat Teeth Which Have Become Infected or Painful Following Trauma Completed NCT01817413 Phase 4
13 Efficacy of Calcium Silicate Pulp-capping; a Randomized Controlled Clinical Trial Active, not recruiting NCT02201641 Phase 4
14 Efficacy of Tetracaine/Oxymetazoline Nasal Spray for Endodontic Treatment Not yet recruiting NCT03502135 Phase 4 Tetracaine HCl and oxymetazoline HCl nasal spray
15 : Pulpal Blood Flow With the Use of Intra-nasal Anesthetic Not yet recruiting NCT03368391 Phase 4 tetracaine HCl and oxymetazoline HCL;2% Lidocaine with 1:100,000 epinephrine;3% Mepivacaine with 1:100,000 epinephrine;saline intranasal;saline infiltration
16 Effect of Preoperative Diclofenac Potassium on Postoperative Endodontic Pain Completed NCT03341260 Phase 2, Phase 3 Diclofenac Potassium 50mg Tab.;Placebo
17 Pretreatment Aceclofenac Effect on Pain and Analgesic Intake After Endodontic Treatment Completed NCT03335007 Phase 2, Phase 3 Aceclofenac
18 Pre-operative Aceclofenac on the Anesthetic Efficacy of IANB in Symptomatic Irreversible Pulpitis Completed NCT03146481 Phase 2, Phase 3 Aceclofenac
19 Effect of Inferior Alveolar and Gow-Gates Nerve Block Techniques for Symptomatic Mandibular Molars Completed NCT03117491 Phase 3
20 4% Articaine and 2% Lidocaine by Intraligamentary Technique in Irreversible Pulpitis Completed NCT02807298 Phase 3 4%articaine;2% Lignocaine;Epinephrine
21 Calcium Hydroxide, Mineral Trioxide Aggregate and Biodentine (Trademark) as Direct Pulp Capping of Permanent Teeth Completed NCT02492841 Phase 2, Phase 3 Mineral trioxide aggregate;Calcium hydroxide;Biodentine
22 Effect of Sodium Bicarbonate Buffered Lidocaine on the Success of IAN Block of Teeth With Irreversible Pulpitis Completed NCT02226913 Phase 3 2% lidocaine with 1:80,000 epinephrine;sodium bicarbonate;placebo
23 Human Pulpal Response After Pulp Capping With Four Different Agents Completed NCT01468480 Phase 2, Phase 3 Pro Root MTA;Pro Root MTA- single visit;MultiCal;Dycal
24 Partial Pulpotomy on Caries Free Human Teeth Completed NCT01420718 Phase 2, Phase 3 MTA;iRoot BP
25 Assessment of a New Apexification Method for Patients Presenting a Non Vital Immature Tooth Completed NCT00472173 Phase 3 Mineral Trioxide Aggregate;Calcium hydroxide
26 Nanodiamond-Gutta Percha Composite Biomaterials for Root Canal Therapy Recruiting NCT03376984 Phase 2, Phase 3
27 Effect of Preoperative Diclofenac Potassium on Articaine Buccal Infitration Success Recruiting NCT03174860 Phase 2, Phase 3 Diclofenac Potassium 50mg Tab;Placebo
28 Clinical Comparison of Endodontically Treated Teeth Restored With Fiber Posts or Cast Metal Posts Recruiting NCT01461239 Phase 3
29 Efficacy of Oral Prednisolone on Pain Reduction in Emergency Care of Acute Irreversible Pulpitis Recruiting NCT02629042 Phase 3 prednisolone
30 Evaluation the Post Operative Pain of Endodontic Treated Molar Tooth With Race and Reciprocal Systems Among Bandarabbas Patients in 2017 Recruiting NCT03488836 Phase 2, Phase 3
31 Evaluation of Postoperative Pain After Using 3MIX-TATIN Versus Calcium Hydroxide Iodoform Paste In Necrotic Primary Molars Treated by Lesion Sterilization and Tissue Repair Therapy Recruiting NCT03084601 Phase 2, Phase 3 Calcium Hydroxide, Iodoform, paste;3-mixtatin
32 Diclofenac Potassium on IANB Efficacy in Symptomatic Irreversible Pulpitis Active, not recruiting NCT03163420 Phase 2, Phase 3 Diclofenac potassium
33 Regenerative Endodontic Procedure of Immature Permanent Teeth With L-PRF: a Pilot Controlled, Clinical Trial Active, not recruiting NCT02437708 Phase 3
34 Revascularization of Immature Anterior Necrotic Teeth Not yet recruiting NCT03504332 Phase 3
35 A Clinical Study: the Antibacterial Effect of Insoluble Antibacterial Nanoparticles (IABN) Incorporated in Dental Materials for Root Canal Treatment Unknown status NCT01167985 Phase 2
36 Effect Of Different Lining Materials in Stepwise Excavation Unknown status NCT01730287 Phase 2 Control;Calcium Hydroxide;Mineral Trioxide Aggregate(MTA);CEM cement
37 Efficacy of Chlorexidine as Intracanal Medicament in Primary Teeth Unknown status NCT00624572 Phase 2 chlorexidine
38 Photodynamic Therapy in Endodontic Treatment Completed NCT02824601 Phase 2 Calcium hydroxide
39 Application of Photodynamic Therapy and Diode Laser for Endodontic Therapy of Young Permanent Teeth Completed NCT03074136 Phase 2 0.5% Sodium hypochlorite
40 Endodontic Treatment of Primary Teeth Using Mineral Trioxide Aggregate Paste Completed NCT02887456 Phase 2 Endodontic treatment using Vitapex;Endodontic treatment using MTA paste
41 Premedication Efficacy of Oral Ketorolac and Ketorolac/ Acetaminophen on Post Treatment Pain Completed NCT02614118 Phase 2 Ketorolac tromethamine;Acetaminophen;Placebo
42 Effect of Premedication on Success of Inferior Alveolar Nerve Block Injection Completed NCT02601911 Phase 2 Ketorolac Tromethamine;Acetaminophen
43 Effect of Fentanyl on the Rate of Anesthesia Completed NCT01794533 Phase 2 Lidocaine with Epinephrine+ Normal saline;Lidocaine with Epinephrine + fentanyl
44 Effect of Sufentanil on the Rate of Anesthesia Completed NCT01572116 Phase 2 Lidocaine with Epinephrine+ Normal saline;Lidocaine with Epinephrine + sufentanil
45 The Effects of Three Oral Medications on Post-operative Pain Following Endodontic Treatment Completed NCT01178203 Phase 1, Phase 2 Placebo;Tramadol;Novafen;Naproxen
46 MTA/FS Pulpotomy for Vital Primary Incisors: A Randomized Controlled Trial Completed NCT02019563 Phase 2
47 Chlorhexidine Intracanal Medicament in Periodontal Healing in Concomitant Endo Perio Lesion With Communication Completed NCT02627326 Phase 2
48 Efficacy of Different Drugs to Control Post Root Canal Treatment Pain Completed NCT02417337 Phase 2 Paracetamol;Ibuprofen;Mefenamic acid;Diclofenac
49 Postoperative Pain Evaluation of Mineral Trioxide Aggregate and Propolis After Pulpotomy in Primary Carious Molars Recruiting NCT03580135 Phase 2 Propolis;Mineral Trioxide Aggregate
50 A Clinical Study to Compare Two Revascularization Protocols to Treat Non-vital Teeth With Incomplete Root Formation Recruiting NCT01827098 Phase 2

Search NIH Clinical Center for Dental Pulp Disease

Cochrane evidence based reviews: dental pulp diseases

Genetic Tests for Dental Pulp Disease

Anatomical Context for Dental Pulp Disease

MalaCards organs/tissues related to Dental Pulp Disease:

Testes, Bone

Publications for Dental Pulp Disease

Articles related to Dental Pulp Disease:

# Title Authors Year
Effects of combining CBCT technology with visual root canal recurrence in treatment of elderly patients with dental pulp disease. ( 28338208 )
Diagnostic imaging in veterinary dental practice. Dental pulp disease in a river otter. ( 23971840 )

Variations for Dental Pulp Disease

Expression for Dental Pulp Disease

Search GEO for disease gene expression data for Dental Pulp Disease.

Pathways for Dental Pulp Disease

Pathways related to Dental Pulp Disease according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
Show member pathways
11.98 CXCL8 IL1B TNF
2 11.8 CXCL8 IL1B TNF
3 11.77 CXCL8 IL1B TNF
4 11.7 CXCL8 IL1B TNF
Show member pathways
6 11.67 CXCL8 IL1B TNF
7 11.65 CXCL8 IL1B TNF
8 11.61 CXCL8 IL1B TNF
Show member pathways
10 11.51 CXCL8 IL1B TNF
11 11.41 CXCL8 IL1B TNF
Show member pathways
11.38 CXCL8 IL1B TNF
13 11.28 CXCL8 IL1B TNF
14 11.19 CXCL8 IL1B TNF
15 11.14 CXCL8 IL1B TAC1 TNF
16 11.12 CXCL8 IL1B TNF
17 10.96 CXCL8 TNF
18 10.92 IL1B TNF
19 10.85 CXCL8 TNF
20 10.76 IL1B TNF

GO Terms for Dental Pulp Disease

Cellular components related to Dental Pulp Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.23 CXCL8 DSPP IL1B LRRC7 MCAM NPS

Biological processes related to Dental Pulp Disease according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of interleukin-8 production GO:0032757 9.56 IL1B TNF
2 response to pain GO:0048265 9.55 TAC1 TRPV1
3 embryonic digestive tract development GO:0048566 9.54 CXCL8 TNF
4 negative regulation of lipid catabolic process GO:0050995 9.52 IL1B TNF
5 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.51 IL1B TNF
6 positive regulation of synaptic transmission, GABAergic GO:0032230 9.49 NPS TAC1
7 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.48 IL1B TNF
8 positive regulation of chemokine biosynthetic process GO:0045080 9.46 IL1B TNF
9 regulation of establishment of endothelial barrier GO:1903140 9.43 IL1B TNF
10 positive regulation of action potential GO:0045760 9.4 NPS TAC1
11 positive regulation of fever generation GO:0031622 9.37 IL1B TNF
12 inflammatory response GO:0006954 9.35 CXCL8 IL1B TAC1 TNF TRPV1
13 positive regulation of nitric oxide biosynthetic process GO:0045429 9.33 IL1B TNF TRPV1
14 fever generation GO:0001660 9.32 IL1B TRPV1
15 sequestering of triglyceride GO:0030730 9.26 IL1B TNF
16 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 8.62 IL1B TNF

Sources for Dental Pulp Disease

9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
70 SNOMED-CT via Orphanet
72 Tocris
74 UMLS via Orphanet
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