Aliases & Classifications for Dental Pulp Disease

MalaCards integrated aliases for Dental Pulp Disease:

Name: Dental Pulp Disease 12 15 17
Dental Pulp Diseases 43 71
Disorder of Pulp of Tooth 12
Dental Pulp Disorder 12
Pulp Disorder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5330
MeSH 43 D003788
NCIt 49 C34530
SNOMED-CT 67 57203004
UMLS 71 C0011405

Summaries for Dental Pulp Disease

MalaCards based summary : Dental Pulp Disease, also known as dental pulp diseases, is related to dental pulp necrosis and carbamazepine allergy, and has symptoms including toothache An important gene associated with Dental Pulp Disease is DSPP (Dentin Sialophosphoprotein), and among its related pathways/superpathways are Akt Signaling and Toll-like Receptor Signaling Pathway. The drugs leucovorin and Pemetrexed have been mentioned in the context of this disorder. Affiliated tissues include bone, eye and liver, and related phenotypes are cardiovascular system and hematopoietic system

Related Diseases for Dental Pulp Disease

Diseases related to Dental Pulp Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 456)
# Related Disease Score Top Affiliating Genes
1 dental pulp necrosis 27.8 NT5E MCAM IBSP ENG DSPP DMP1
2 carbamazepine allergy 10.5 TAC1 NPS
3 angelucci's syndrome 10.5 IL1B CXCL8
4 dermatitis, atopic, 8 10.5 IL1B CXCL8
5 systemic onset juvenile idiopathic arthritis 10.5 TNF IL1B
6 staphylococcal toxic shock syndrome 10.4 TNF IL1B
7 esophagus melanoma 10.4 IL1B CXCL8
8 gingival recession 10.4 IL1B DSPP BMP2
9 vulvar vestibulitis syndrome 10.4 TNF IL1B
10 osteosclerotic myeloma 10.4 IL6 IL1B
11 palladium allergic contact dermatitis 10.4 TNF IL1B
12 periodontitis, chronic 10.4 IL6 IL1B
13 kashin-beck disease 10.4 TNF IL1B
14 external pathological resorption 10.4 TNF IL6
15 autoimmune vasculitis 10.4 TNF IL1B CCR6
16 mycobacterium chelonae 10.4 TLR2 CXCL8
17 uremic pruritus 10.4 IL6 IL1B
18 scorpion envenomation 10.4 TNF IL6
19 myofascial pain syndrome 10.4 TRPV1 TAC1 NPS
20 vasomotor rhinitis 10.3 TRPV1 TAC1 NPS
21 trigeminal nerve disease 10.3 TRPV1 TAC1 NPS
22 mycobacterium marinum 10.3 TLR2 CXCL8
23 acute transverse myelitis 10.3 IL6 CXCL8
24 trigeminal neuralgia 10.3 TRPV1 TAC1 NPS
25 pouchitis 10.3 TLR4 CXCL8
26 paine syndrome 10.3 TRPV1 TAC1 NPS
27 mycobacterium kansasii 10.3 TLR2 CXCL8
28 pustulosis of palm and sole 10.3 TNF CXCL8 CCR6
29 angioimmunoblastic lymphadenopathy with dysproteinemia 10.3 TNF IL6
30 cardiac sarcoidosis 10.3 TNF IL1B CXCL8
31 bone development disease 10.3 IBSP BMP2 BGLAP
32 opisthorchiasis 10.3 TNF IL1B CXCL8
33 recurrent corneal erosion 10.3 IL6 IL1B CXCL8
34 mononeuropathy 10.3 TRPV1 TNF TAC1
35 fibrous dysplasia 10.3 IL6 IBSP BGLAP
36 dental fluorosis 10.3 DSPP BGLAP AMELX
37 pyoderma 10.3 TNF CXCL8 CCR6
38 pyoderma gangrenosum 10.3 TNF CXCL8 CCR6
39 yellow fever 10.3 IL6 IL1B CCR6
40 cyclic neutropenia 10.3 TNF IL1B CXCL8
41 neurosyphilis 10.3 TLR2 CXCL8
42 perianal hematoma 10.3 TAC1 NPS
43 conjunctivochalasis 10.2 IL6 IL1B CXCL8
44 ascaris lumbricoides infection 10.2 IL6 IL1B CXCL8
45 scleral disease 10.2 TNF IL6 CCR6
46 paranasal sinus disease 10.2 TNF CXCL8 CCR6
47 autoimmune disease of cardiovascular system 10.2 TNF IL6 CCR6
48 aseptic meningitis 10.2 TNF IL1B CXCL8
49 iritis 10.2 TNF IL6 CCR6
50 stachybotrys chartarum 10.2 TNF IL6 IL1B

Graphical network of the top 20 diseases related to Dental Pulp Disease:



Diseases related to Dental Pulp Disease

Symptoms & Phenotypes for Dental Pulp Disease

UMLS symptoms related to Dental Pulp Disease:


toothache

MGI Mouse Phenotypes related to Dental Pulp Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.13 BMP2 CCR6 DMP1 ENG IL1B IL6
2 hematopoietic system MP:0005397 9.93 BMP2 CCR6 DMP1 ENG IBSP IL1B
3 craniofacial MP:0005382 9.8 BMP2 DMP1 ENG IBSP IL1B NT5E
4 immune system MP:0005387 9.7 BMP2 CCR6 DMP1 IBSP IL1B IL6
5 integument MP:0010771 9.28 ENG IL1B IL6 NT5E TAC1 TLR2

Drugs & Therapeutics for Dental Pulp Disease

Drugs for Dental Pulp Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 81)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
leucovorin Approved Phase 4 58-05-9 6006 143
2
Pemetrexed Approved, Investigational Phase 4 150399-23-8, 137281-23-3 446556 60843
3
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
4
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
5
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
6
Racepinephrine Approved Phase 4 329-65-7 838
7
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
8
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
9 Folic Acid Antagonists Phase 4
10 Vitamin B Complex Phase 4
11 Vitamin B9 Phase 4
12 Folate Phase 4
13 Anti-Asthmatic Agents Phase 4
14 Adrenergic beta-Agonists Phase 4
15 Bronchodilator Agents Phase 4
16 Antibiotics, Antitubercular Phase 4
17 Antitubercular Agents Phase 4
18 Anti-Bacterial Agents Phase 4
19 Calcium, Dietary Phase 4
20 Hormones Phase 4
21 Carticaine Phase 4
22 Anti-Arrhythmia Agents Phase 4
23 Epinephryl borate Phase 4
24 Sodium Channel Blockers Phase 4
25 Diuretics, Potassium Sparing Phase 4
26
Edetic Acid Approved, Vet_approved Phase 2, Phase 3 60-00-4, 62-33-9 6049
27
acetic acid Approved Phase 2, Phase 3 64-19-7 176
28
Iron Approved, Experimental Phase 2, Phase 3 7439-89-6, 15438-31-0 23925 27284
29
Pentetic acid Approved Phase 2, Phase 3 67-43-6
30
Amoxicillin Approved, Vet_approved Phase 2, Phase 3 26787-78-0 33613
31 Disinfectants Phase 2, Phase 3
32
Retinol acetate Phase 2, Phase 3 127-47-9 10245972
33 Chlorhexidine gluconate Phase 2, Phase 3
34 Chelating Agents Phase 2, Phase 3
35 Anticoagulants Phase 2, Phase 3
36 Iron Chelating Agents Phase 2, Phase 3
37 Dermatologic Agents Phase 2, Phase 3
38 Anti-Infective Agents, Local Phase 2, Phase 3
39 Root Canal Irrigants Phase 2, Phase 3
40
Methylene blue Approved, Investigational Phase 2 61-73-4
41
Sodium citrate Approved, Investigational Phase 2 68-04-2
42
Silicon Approved, Investigational Phase 2 7440-21-3 4082203
43
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
44
Citric acid Approved, Nutraceutical, Vet_approved Phase 2 77-92-9 311
45
Vitamin A Approved, Nutraceutical, Vet_approved Phase 2 68-26-8, 11103-57-4, 22737-96-8 445354 9904001
46 Citrate Phase 2
47 Photosensitizing Agents Phase 2
48
Bismuth Phase 2 7440-69-9 16682734 105143
49 Anti-Inflammatory Agents Phase 2
50 Vitamins Phase 2

Interventional clinical trials:

(show all 36)
# Name Status NCT ID Phase Drugs
1 Success Rate Evaluation of Miniature Pulpotomy With MTA in Primary Molars Unknown status NCT02286648 Phase 4 Formocresol;Mineral Trioxide Aggregate
2 Success and Color Stability of MTA Pulpotomized Primary Molars: an RCT Unknown status NCT02702505 Phase 4
3 Pulpal Blood Flow With the Use of Intra-nasal Anesthetic: a Randomized Double-blind Crossover Study Unknown status NCT03368391 Phase 4 tetracaine HCl and oxymetazoline HCL;2% Lidocaine with 1:100,000 epinephrine;3% Mepivacaine with 1:100,000 epinephrine;saline intranasal;saline infiltration
4 Articaine Versus Lidocaine Supplemental Infiltration Efficacy in Irreversible Pulpitis Mandibular Molars After Failed Inferior Alveolar Nerve Block Completed NCT01496846 Phase 4 IANB Articaine;SUP Articaine;SUP Lidocaine
5 The Clinical Comparative Evaluation Of Postoperative Pain In Single-Visit And Multiple-Visit Pretreatment Cases: A Prospective Randomized Clinical Trial Completed NCT03042377 Phase 4 Multiple-Visit-"Calcium Hydroxide";Multiple-Visit-"Corticosteroid Paste";Multiple-Visit-"Antibiotic Paste"
6 Efficacy of Tetracaine/Oxymetazoline Nasal Spray for Endodontic Treatment Withdrawn NCT03502135 Phase 4 Tetracaine HCl and oxymetazoline HCl nasal spray
7 In-vivo Comparison of Antibacterial Efficacy of Three Different Solutions as Final Irrigant During Endodontic Therapy: A Randomized Controlled Trial Completed NCT03853200 Phase 2, Phase 3 QMix Root Canal Irrigant;17%EDTA+2%Chlorhexidine
8 Nanodiamonds and Antibiotics Modified Gutta-percha (NDGX) for Non-surgical Root Canal Therapy (RCT) Filler Material Recruiting NCT03376984 Phase 2, Phase 3
9 Endodontic Treatment of Primary Teeth With Guedes-Pinto Paste Without Antibiotic: Randomized Non-inferiority Clinical Trial Active, not recruiting NCT03839485 Phase 3 Endodontic treatment using Guedes-Pinto Paste;Endodontic using Guedes-Pinto Paste without antibiotic
10 Does Supplemental Photodynamic Therapy Optimize the Disinfection of Bacteria and Endotoxins in One-visit and Two-visit Root Canal Therapy? A Randomized Clinical Trial Completed NCT02824601 Phase 2 Calcium hydroxide
11 Postoperative Pain Evaluation of Mineral Trioxide Aggregate and Propolis After Pulpotomy in Carious Primary Molars: A Randomized Controlled Trial Active, not recruiting NCT03580135 Phase 2 Propolis;Mineral Trioxide Aggregate
12 Clinical Evaluation of Sodium Hypochlorite Pulpotomies in Primary Molars: A Long-Term Follow-Up in Comparison With Conventional 20% Formocresol Pulpotomies Unknown status NCT02137967 Early Phase 1 2.5% NaOCl;20% Formocresol
13 Application of Different Biomaterials in the Preservation of Vital Pulp in Carious Deciduous Teeth: a Prospective, Single-center, Randomized, Controlled Clinical Trial Unknown status NCT03220360
14 Monocentric Study and Prognostic of Treatments Endodontics of Teeth With Periapical Pathology Realized CSERD (Nantes University Hospital) Completed NCT02819258
15 Sodium Channel Expression in Human Teeth Completed NCT00575263
16 Long-term Evaluation of Endodontic Root Canal Treatments: Complication, Factors Affecting Failure, New Disease and Success Completed NCT03215225
17 Effect of Platelet-Rich Plasma Biomembrane on Enhancing Bone Regeneration Following Endodontic Surgery:A Prospective Randomized Clinical Trial Completed NCT04109417
18 Three-dimensional Analysis of the Root Canal Preparation With Reciproc Blue, WaveOne Gold and XP EndoShaper Completed NCT03680534
19 Development of a Model to Evaluate Regenerative Endodontic Techniques Completed NCT00595595
20 An in Vivo Evaluation of the ProMark, Root ZX II, and NRG Rider Electronic Apex Locators on the Accuracy of Working Length of Molars Completed NCT02521909
21 Clinical and Radiographic Evaluation of Biodentine Versus Formocresol in Vital Pulpotomy of Primary Molars: (A Randomized Control Clinical Trial) Completed NCT03582319
22 Effect of Different Root Canal Instruments on Removal of Endotoxins From Necrotic Root Canals (A Randomized Clinical Trial) Completed NCT03641612
23 The Endocrown; a Prospective Randomised Clinical Trial of Three Different Ceramics Recruiting NCT03542019
24 Nanodiamond Modified Gutta Percha (NDGP) Composite for Non-surgical Root Canal Therapy (RCT) Filler Material Applied by Vertical Condensation Obturation Procedure Recruiting NCT02698163
25 Clinical Evaluation of Vital Pulp Therapy in Young Permanent Molars With Irreversible Pulpitis Recruiting NCT03410134
26 "Clinical and CBCT Evaluation of the Quality of Obturation and Time Efficiency of Rotary Versus Manual Instrumentation in Pediatric Endodontics" Recruiting NCT04102293
27 Impact of an Enhanced Sterile Protocol on Root Canal Treatment Outcome Recruiting NCT03636087
28 N-Acetyl Cysteine Helps Pulp Stem Cells Differentiate During Endodontic Revascularization Recruiting NCT03451435 Early Phase 1 N acetyl cysteine
29 Digitized Assessment for the Survival of Mature Anterior Teeth With Periapical Lesion After One Step Regenerative Approach Using Different Asepsis Maneuvers Recruiting NCT03652129
30 Evaluation of Clinical and Radiological Success of Vital Amputation Treatment Applied in Teeth With Irreversible Pulpitis Using MTA Recruiting NCT03883295
31 Comparative Randomized Clinical Comparison of Pulp Chamber Pulpotomy and Root Canal Treatment (Pulpectomy) as a Permanent Endodontic Treatment of Mature Permanent Teeth: Analysis of Relationship Between Inflammation Biomarkers Pulpal Expression and Treatment Outcome Recruiting NCT02727088
32 Effect of Three Mechanical Systems on Removal of Endotoxins From Necrotic Teeth With Apical Periodontitis After Two-visit RCT Enrolling by invitation NCT04200638
33 The Success and Survival of Teeth and Restoration Following Root Canal Treatment With Varying Degrees of Tooth Structure Loss Restored With CAD CAM Restorations. Not yet recruiting NCT03378778
34 Evaluation of Three Pulp Vitality Tests Not yet recruiting NCT02636504
35 Clinical and Radiographic Success of Guided Versus Conventional Periapical Endodontic Surgery: A Randomized Controlled Trial Not yet recruiting NCT04133181
36 Post-operative Pain Following Treatment Using the Gentlewave System Not yet recruiting NCT03635515

Search NIH Clinical Center for Dental Pulp Disease

Cochrane evidence based reviews: dental pulp diseases

Genetic Tests for Dental Pulp Disease

Anatomical Context for Dental Pulp Disease

MalaCards organs/tissues related to Dental Pulp Disease:

40
Bone, Eye, Liver, Testes, Spinal Cord, Lung, Monocytes

Publications for Dental Pulp Disease

Articles related to Dental Pulp Disease:

(show all 45)
# Title Authors PMID Year
1
Teneligliptin inhibits lipopolysaccharide-induced cytotoxicity and inflammation in dental pulp cells. 61
31078926 2019
2
Role and mechanism of the nod-like receptor family pyrin domain-containing 3 inflammasome in oral disease. 61
30315987 2019
3
[Comparison of the properties of CD146 positive and CD146 negative subpopulations of stem cells from human exfoliated deciduous teeth]. 61
29643528 2018
4
[Vital pulp therapy of damaged dental pulp]. 61
28853497 2017
5
Effects of combining CBCT technology with visual root canal recurrence in treatment of elderly patients with dental pulp disease. 61
28338208 2017
6
Decellularized Swine Dental Pulp as a Bioscaffold for Pulp Regeneration. 61
29387727 2017
7
[Cause and regulation of pain during root canal therapy]. 61
28326697 2016
8
[Clinical analysis for systemic complications of patients in the dental emergency room]. 61
25882958 2015
9
Diagnostic imaging in veterinary dental practice. Dental pulp disease in a river otter. 61
23971840 2013
10
Radiological diagnosis of periapical bone tissue lesions in endodontics: a systematic review. 61
22429152 2012
11
Identify and determine the metrics, hierarchy, and predictive value of all the parameters and/or methods used during endodontic diagnosis. 61
19932338 2009
12
[Dental pulp diseases. Ultramicroscopic studies]. 61
10207299 1998
13
Human polymorphonuclear granule components: relative levels detected by a modified enzyme-linked immunosorbent assay in normal and inflamed dental pulps. 61
1812201 1991
14
[Therapeutic local anesthesia in treatment of dental pulp diseases]. 61
2816122 1989
15
[Comparative study on the antibacterial and antiphlogistic action of a new pharmaceutical in the treatment of dental pulp diseases]. 61
3507056 1987
16
[Experimental studies on the bactericidal activity of various agents used in the treatment of dental pulp diseases in deciduous teeth]. 61
3115686 1987
17
[Cerebral bioelectric effects in dental pulp disease. 1: Experimental basis]. 61
3467484 1986
18
[Credibility of clinical determination of dental pulp disease using histopathological findings]. 61
3870411 1985
19
[The incidence of dental pulp diseases in relation to influenza epidemics]. 61
6675136 1983
20
[Classification of dental pulp diseases]. 61
6961051 1982
21
[Periodontal and dental pulp diseases]. 61
7188226 1982
22
[Dental pulp diseases of the deciduous teeth. II. Clinical classification]. 61
274851 1978
23
[Influence of hydrone on the dental pulp as compared to other drugs]. 61
724568 1978
24
[Diagnosis and treatment of dental pulp diseases in deciduous molars]. 61
265806 1977
25
[Methods of diagnosis of dental pulp diseases]. 61
271334 1977
26
[Diagnosis of dental pulp diseases]. 61
786561 1976
27
[Therapy of dental pulp diseases in the deciduous teeth]. 61
1066235 1976
28
[Testing the electric resistance as an objective diagnostic test in dental pulp diseases]. 61
137616 1976
29
[Pathology of dental pulp diseases]. 61
1073172 1976
30
[Clinical classification of dental pulp diseases]. 61
1059527 1975
31
[Iatrogenic factors in dental pulp diseases]. 61
1057496 1975
32
[Management of dental pulp diseases]. 61
4533823 1974
33
[Hematological studies in dental pulp diseases]. 61
4525109 1974
34
[Review of diagnostic tests in the dental pulp diseases]. 61
4465237 1974
35
[Treatment of category IV of dental pulp diseases. I. Terminology, etiology and pathology of dental pulp necrosis]. 61
4507852 1972
36
[Review of clinical cases of dental pulp diseases]. 61
5208267 1970
37
[Causes of dental pulp diseases]. 61
5260242 1969
38
[Comparisons between clinical and histopathological diagnosis of dental pulp diseases]. 61
5253283 1968
39
[Anion exchange resins in the conservative biological therapy of dental pulp diseases]. 61
5244028 1968
40
[Observations on the correlation between clinical and histopathological diagnosis of dental pulp diseases in school-age children]. 61
4233572 1967
41
[THE SPECIFICITY OF CLINICAL CONDITIONS AND THE RESULTS OF TREATMENT OF CERTAIN DENTAL PULP DISEASES BY MEANS OF DEVITALIZATION]. 61
14326532 1965
42
[Our experiences in the treatment of dental pulp diseases with corticosteroids]. 61
5219408 1964
43
[Dental pulp diseases]. 61
13111015 1953
44
[Classification of dental pulp diseases and basic methods of their therapy]. 61
13048933 1952
45
Aids in diagnosing dental pulp diseases. 61
21026127 1946

Variations for Dental Pulp Disease

Expression for Dental Pulp Disease

Search GEO for disease gene expression data for Dental Pulp Disease.

Pathways for Dental Pulp Disease

Pathways related to Dental Pulp Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.44 TNF TLR4 TLR2 IL6 IL1B CXCL8
2
Show member pathways
13.13 TNF TLR4 TLR2 IL6 IL1B CXCL8
3
Show member pathways
12.96 TNF TLR4 TLR2 IL6 IL1B CXCL8
4
Show member pathways
12.85 TNF TLR4 TLR2 IL6 IL1B CXCL8
5
Show member pathways
12.78 TNF TLR4 IL6 IL1B CXCL8
6
Show member pathways
12.73 TNF TLR4 TLR2 IL6 IL1B BMP2
7
Show member pathways
12.63 TNF TLR4 TLR2 IL6 IL1B
8
Show member pathways
12.63 TNF TLR4 TLR2 IL6 IL1B
9 12.39 TNF TLR4 IL1B CXCL8
10
Show member pathways
12.37 TNF TLR2 IL6 IL1B CXCL8
11
Show member pathways
12.35 TNF TLR4 IL6 IL1B CXCL8
12
Show member pathways
12.34 TNF IL6 CXCL8 CCR6
13 12.31 TNF TLR4 IL6 IL1B CXCL8
14
Show member pathways
12.29 TNF IL6 IL1B CXCL8 BMP2
15
Show member pathways
12.28 TNF TLR4 TLR2 IL1B
16
Show member pathways
12.28 TNF TLR4 TLR2 IL6 CXCL8
17 12.25 TNF TLR4 IL6 IL1B CXCL8
18 12.24 TNF TLR4 TLR2 IL6 IL1B
19 12.22 TNF TLR4 TLR2 IL6
20
Show member pathways
12.22 TNF TLR2 IL6 IL1B CXCL8
21 12.16 TNF TAC1 IL6 IL1B CXCL8
22 12.03 TNF THY1 IL6 ENG
23 12.02 TNF IL6 IL1B CXCL8
24
Show member pathways
12.02 TNF TLR4 TLR2 IL6 IL1B
25
Show member pathways
12.02 TNF TLR4 TLR2 IL6 IL1B CXCL8
26 11.98 IL6 IL1B CXCL8 BMP2
27
Show member pathways
11.98 TNF TLR4 TLR2 IL6 IL1B
28 11.96 TNF TLR4 IL1B CXCL8
29 11.94 TNF IL6 IL1B CXCL8
30 11.93 TNF TLR4 IL6 IL1B CXCL8
31 11.91 TNF TLR4 IL6 IL1B CXCL8
32 11.83 TLR4 IL6 IL1B CXCL8
33 11.82 TNF THY1 IL1B CCR6
34 11.81 IL6 CXCL8 BGLAP
35 11.78 TNF THY1 IL6 IL1B
36 11.74 TNF IL6 IL1B
37 11.74 TNF TLR4 TLR2 IL6 IL1B CXCL8
38
Show member pathways
11.67 TNF IL6 IL1B CXCL8
39 11.66 TNF IL6 IL1B CXCL8
40 11.65 TNF TLR4 IL6 IL1B CXCL8
41 11.63 IBSP DSPP DMP1
42 11.6 TNF TLR4 TLR2 IL6 IL1B CXCL8
43 11.56 TNF THY1 IL6
44 11.53 TNF IL6 IL1B CXCL8
45 11.51 TNF TLR4 TLR2 IL1B
46 11.45 TNF IL6 IL1B BGLAP
47 11.43 TNF IL6 IL1B
48 11.39 IL6 CXCL8 BGLAP
49 11.36 TNF IL6 IL1B
50 11.34 TNF IL6 IL1B

GO Terms for Dental Pulp Disease

Cellular components related to Dental Pulp Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.96 TNF TAC1 MCAM IL6 IL1B IBSP
2 external side of plasma membrane GO:0009897 9.7 TRPV1 TNF TLR4 THY1 MCAM ENG
3 cell surface GO:0009986 9.61 TNF TLR4 TLR2 THY1 NT5E ENG
4 intrinsic component of plasma membrane GO:0031226 9.5 TRPV1 TLR4 TLR2
5 extracellular region GO:0005576 9.47 TNF THY1 TAC1 NPS MCAM IL6

Biological processes related to Dental Pulp Disease according to GeneCards Suite gene sharing:

(show all 50)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.23 TNF TLR4 TLR2 IL6 IL1B ENG
2 cell adhesion GO:0007155 10.13 THY1 MCAM IBSP ENG BGLAP AMELX
3 negative regulation of cell proliferation GO:0008285 10.09 TLR2 IL6 IL1B CXCL8 BMP2
4 immune response GO:0006955 10.02 TNF TLR4 TLR2 IL6 IL1B CXCL8
5 angiogenesis GO:0001525 10.01 THY1 MCAM ENG CXCL8
6 extracellular matrix organization GO:0030198 10 TNF IBSP DSPP DMP1
7 cell-cell signaling GO:0007267 10 THY1 TAC1 IL1B BMP2
8 positive regulation of gene expression GO:0010628 9.98 TNF TLR4 TLR2 IL6 IL1B ENG
9 positive regulation of protein phosphorylation GO:0001934 9.97 TNF IL1B ENG BMP2
10 response to lipopolysaccharide GO:0032496 9.97 TLR4 TLR2 TAC1 IL1B
11 cellular response to lipopolysaccharide GO:0071222 9.93 TNF TLR4 IL6 IL1B CXCL8
12 activation of MAPK activity GO:0000187 9.92 TNF TLR4 IL1B BMP2
13 osteoblast differentiation GO:0001649 9.91 IBSP BMP2 BGLAP AMELX
14 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.89 TNF TLR4 TLR2 IL6 IL1B
15 cellular response to mechanical stimulus GO:0071260 9.88 TLR4 IL1B ENG
16 ossification GO:0001503 9.88 DSPP DMP1 BMP2 BGLAP
17 positive regulation of inflammatory response GO:0050729 9.88 TNF TLR4 TLR2 IL1B
18 cellular response to organic cyclic compound GO:0071407 9.87 TNF IL1B BMP2
19 response to glucocorticoid GO:0051384 9.86 TNF IL6 BGLAP
20 humoral immune response GO:0006959 9.85 TNF IL6 CCR6
21 cellular response to growth factor stimulus GO:0071363 9.85 TRPV1 IBSP BMP2 BGLAP
22 positive regulation of epithelial to mesenchymal transition GO:0010718 9.83 IL6 IL1B BMP2
23 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.83 TNF TLR4 TLR2 IL1B
24 positive regulation of interferon-gamma production GO:0032729 9.82 TNF TLR4 IL1B
25 bone mineralization GO:0030282 9.82 IBSP BMP2 BGLAP
26 microglial cell activation GO:0001774 9.79 TRPV1 TNF TLR2
27 negative regulation of neurogenesis GO:0050768 9.78 TNF IL6 IL1B
28 positive regulation of nitric oxide biosynthetic process GO:0045429 9.76 TRPV1 TNF TLR4 IL1B
29 positive regulation of glial cell proliferation GO:0060252 9.74 TNF IL6 IL1B
30 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.73 TNF THY1 IL1B
31 positive regulation of chemokine biosynthetic process GO:0045080 9.71 TNF IL1B
32 positive regulation of interleukin-6 secretion GO:2000778 9.71 TNF TLR4 TLR2 IL1B
33 cellular response to lipoteichoic acid GO:0071223 9.7 TLR4 TLR2
34 negative regulation of lipid storage GO:0010888 9.69 TNF IL6
35 positive regulation of neuroinflammatory response GO:0150078 9.69 TNF IL6 IL1B
36 regulation of establishment of endothelial barrier GO:1903140 9.68 TNF IL1B
37 positive regulation of lymphocyte proliferation GO:0050671 9.68 TLR4 TAC1
38 lipopolysaccharide-mediated signaling pathway GO:0031663 9.67 TNF TLR4 TLR2 IL1B
39 positive regulation of action potential GO:0045760 9.66 TAC1 NPS
40 positive regulation of fever generation GO:0031622 9.66 TNF IL1B
41 sequestering of triglyceride GO:0030730 9.64 TNF IL1B
42 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.63 TNF IL1B
43 fever generation GO:0001660 9.63 TRPV1 IL1B
44 positive regulation of interleukin-8 production GO:0032757 9.62 TNF TLR4 TLR2 IL1B
45 positive regulation of matrix metallopeptidase secretion GO:1904466 9.6 TLR4 TLR2
46 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.59 TLR4 TLR2
47 positive regulation of chemokine production GO:0032722 9.56 TNF TLR4 TLR2 IL6
48 positive regulation of interleukin-6 production GO:0032755 9.55 TNF TLR4 TLR2 IL6 IL1B
49 biomineral tissue development GO:0031214 9.35 IBSP DSPP DMP1 BGLAP AMELX
50 inflammatory response GO:0006954 9.28 TRPV1 TNF TLR4 TLR2 TAC1 IL6

Molecular functions related to Dental Pulp Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide receptor activity GO:0001875 9.26 TLR4 TLR2
2 integrin binding GO:0005178 9.26 THY1 IL1B IBSP DMP1
3 hydroxyapatite binding GO:0046848 9.16 BGLAP AMELX
4 cytokine activity GO:0005125 9.02 TNF IL6 IL1B CXCL8 BMP2

Sources for Dental Pulp Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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