MCID: DNT006
MIFTS: 40

Dental Pulp Necrosis

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Dental Pulp Necrosis

MalaCards integrated aliases for Dental Pulp Necrosis:

Name: Dental Pulp Necrosis 12 43 15 71
Pulp Necrosis 12 54
Necrosis of the Pulp 12
Necrotic Pulp 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11623
ICD9CM 34 522.1
MeSH 43 D003790
SNOMED-CT 67 42711005
ICD10 32 K04.1
UMLS 71 C0011407

Summaries for Dental Pulp Necrosis

MalaCards based summary : Dental Pulp Necrosis, also known as pulp necrosis, is related to root resorption and chronic apical periodontitis. An important gene associated with Dental Pulp Necrosis is DSPP (Dentin Sialophosphoprotein), and among its related pathways/superpathways are Degradation of the extracellular matrix and ECM-receptor interaction. The drugs Ciprofloxacin and Metronidazole have been mentioned in the context of this disorder. Affiliated tissues include bone, salivary gland and testes, and related phenotypes are craniofacial and hematopoietic system

Wikipedia : 74 Pulp necrosis is a clinical diagnostic category indicating the death of cells and tissues in the pulp... more...

Related Diseases for Dental Pulp Necrosis

Diseases related to Dental Pulp Necrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Related Disease Score Top Affiliating Genes
1 root resorption 30.0 TNFSF11 DSPP DMP1
2 chronic apical periodontitis 29.9 TNFSF11 SNRNP40
3 ankylosis 29.8 IBSP BMP2 BGLAP
4 dental pulp disease 27.7 NT5E MCAM IBSP ENG DSPP DMP1
5 periodontitis 10.4
6 dentinogenesis imperfecta 1 10.4 DSPP DMP1
7 suppurative periapical periodontitis 10.4 SPRTN DSPP
8 hair whorl 10.3
9 malignant giant cell tumor of soft parts 10.3 NT5E ENG
10 rapidly involuting congenital hemangioma 10.3
11 ossification of the posterior longitudinal ligament of spine 10.2 BMP2 BGLAP
12 osseous heteroplasia, progressive 10.2 BMP2 BGLAP
13 dentin dysplasia, type ii 10.2 IBSP DSPP DMP1
14 synovial chondromatosis 10.2 FGF2 BMP2
15 tooth erosion 10.2 DSPP AMELX
16 dyssegmental dysplasia, silverman-handmaker type 10.2 FGF2 BMP2
17 dentinogenesis imperfecta 10.2 IBSP DSPP DMP1
18 dentin caries 10.1 MEPE DSPP
19 osteofibrous dysplasia 10.1 BMP2 BGLAP
20 oncogenic osteomalacia 10.1 MEPE DMP1
21 juvenile nasopharyngeal angiofibroma 10.1 FGF2 ENG
22 osteochondroma 10.1 FGF2 BMP2
23 gingival recession 10.1 FGF2 DSPP BMP2
24 angiodysplasia 10.0 FGF2 ENG
25 bacterial infectious disease 10.0
26 pulpitis 10.0
27 pik3ca-related overgrowth syndrome 10.0
28 tibial nerve palsy 10.0 NT5E MCAM ENG
29 hypophosphatemic rickets, x-linked dominant 10.0 MEPE DMP1
30 bone development disease 10.0 IBSP BMP2 BGLAP
31 dental abscess 10.0 MEPE DSPP DMP1
32 osteogenesis imperfecta, type vi 10.0 MEPE IBSP
33 dental fluorosis 9.9 DSPP BGLAP AMELX
34 hypophosphatemic rickets, autosomal dominant 9.9 MEPE DMP1
35 germ cell and embryonal cancer 9.9 NT5E FGF2 ENG
36 hypophosphatemic rickets, x-linked recessive 9.9 MEPE DMP1
37 periodontitis, chronic 9.9
38 cellulitis 9.9
39 herpes simplex 9.9
40 periapical periodontitis 9.9 TNFSF11 SPRTN DSPP
41 raynaud phenomenon 9.8
42 sickle cell anemia 9.8
43 deficiency anemia 9.8
44 inflammatory myofibroblastic tumor 9.8
45 paresthesia 9.8
46 phosphorus metabolism disease 9.8 MEPE DMP1 BGLAP
47 osteoblastoma 9.8 MEPE DMP1
48 osteopetrosis, autosomal dominant 2 9.8 TNFSF11 BGLAP
49 bone benign neoplasm 9.8 MEPE AMELX
50 multicentric carpotarsal osteolysis syndrome 9.8 TNFSF11 BGLAP

Graphical network of the top 20 diseases related to Dental Pulp Necrosis:



Diseases related to Dental Pulp Necrosis

Symptoms & Phenotypes for Dental Pulp Necrosis

MGI Mouse Phenotypes related to Dental Pulp Necrosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.43 BMP2 DMP1 ENG IBSP NT5E TNFSF11
2 hematopoietic system MP:0005397 9.28 BMP2 DMP1 ENG FGF2 IBSP MCAM

Drugs & Therapeutics for Dental Pulp Necrosis

Drugs for Dental Pulp Necrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 129)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
2
Metronidazole Approved Phase 4 443-48-1 4173
3
Cefixime Approved, Investigational Phase 4 79350-37-1 54362 5362065
4
Simvastatin Approved Phase 4 79902-63-9 54454
5
Polymyxin B Approved, Vet_approved Phase 4 1404-26-8
6
Bacitracin Approved, Vet_approved Phase 4 1405-87-4 439542 10909430
7
Neomycin Approved, Vet_approved Phase 4 1404-04-2 8378
8
Zinc Approved, Investigational Phase 4 7440-66-6 32051
9
Eugenol Approved Phase 4 97-53-0 3314
10
Zinc oxide Approved Phase 4 1314-13-2
11
Chloramphenicol succinate Approved Phase 4 3544-94-3
12
Chloramphenicol Approved, Vet_approved Phase 4 56-75-7 298 5959
13
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
14
Ethanol Approved Phase 4 64-17-5 702
15
Xylometazoline Approved, Investigational Phase 4 526-36-3 5709
16
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
17
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
18
Salicylic acid Approved, Investigational, Vet_approved Phase 4 69-72-7 338
19
Ceftibuten Approved, Investigational Phase 4 97519-39-6 5282241 5282242
20
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
21
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
22
Clavulanate Approved, Vet_approved Phase 4 58001-44-8 5280980
23
Sodium citrate Approved, Investigational Phase 4 68-04-2
24
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
25
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
26
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
27
Citric acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
28
Lactitol Investigational Phase 4 585-86-4, 585-88-6 493591
29 Anti-Inflammatory Agents Phase 4
30 Anesthetics Phase 4
31 Cytochrome P-450 Enzyme Inhibitors Phase 4
32 Antiparasitic Agents Phase 4
33 Topoisomerase Inhibitors Phase 4
34 Antiprotozoal Agents Phase 4
35 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
36 Chlorhexidine gluconate Phase 4
37 Anti-Infective Agents, Local Phase 4
38 Polymyxins Phase 4
39 Propolis Phase 4
40 Vasoconstrictor Agents Phase 4
41 Bee Products Phase 4
42 Antiemetics Phase 4
43 HIV Protease Inhibitors Phase 4
44 Gastrointestinal Agents Phase 4
45
protease inhibitors Phase 4
46 Autonomic Agents Phase 4
47 Hormone Antagonists Phase 4
48 BB 1101 Phase 4
49 Antineoplastic Agents, Hormonal Phase 4
50 glucocorticoids Phase 4

Interventional clinical trials:

(show top 50) (show all 81)
# Name Status NCT ID Phase Drugs
1 Evaluation of Postoperative Pain After Using 3MIX-TATIN Versus Calcium Hydroxide Iodoform Paste In Necrotic Primary Molars Treated by Lesion Sterilization and Tissue Repair Therapy: A Randomized Controlled Trial Completed NCT03084601 Phase 4 Calcium Hydroxide, Iodoform, paste;3-mixtatin
2 Efficiency of Triple Antibiotic Mixture and Propolis as Intracanal Medication in Revascularization Process in Immature Apex: A Clinical Study Completed NCT03533231 Phase 4
3 Revascularisation Versus Mineral Trioxide Aggregate in the Management of Non-Vital Immature Permanent Incisors in a Young Population: A Randomised Controlled Trial (Pilot Study) Completed NCT01817413 Phase 4
4 Survival of Primary Molars Treated With Antimicrobial Pulpotomy or Calcium Hydroxide Pulpectomy Completed NCT01010451 Phase 4
5 Effect of Topical Dexamethasone on Histologic Response of Human Dental Pulp Completed NCT02574468 Phase 4 Dexamethasone applied on pulp or Dexamethasone did not applied on pulp
6 Assessment of Postoperative Pain After Using Silver Nanoparticles With and Without Calcium Hydroxide as an Intracanal Medication in Patients With Necrotic Pulp: (A Randomized Clinical Trial) Not yet recruiting NCT03692286 Phase 4 Silver Nanoparticles in gel form;Calcium Hydroxide Intracanal medication
7 Effect of Irrigation With Antibiotic-containing Solutions Versus Sodium Hypochlorite on Postoperative Pain and Intra-canal Bacteria in Teeth With Necrotic Pulps (a Randomized Double-blind Clinical Trial) Not yet recruiting NCT04035070 Phase 4
8 Enhancement of Apexification Procedure Outcome of Non Vital Incompletely Formed Roots Using Apical Matrix Completed NCT03849222 Phase 2, Phase 3 MTA;Ca(OH)2;Apical matrix
9 Assessment of a New Apexification Method for Patients Presenting a Non Vital Immature Tooth Completed NCT00472173 Phase 3 Mineral Trioxide Aggregate;Calcium hydroxide
10 Nanodiamonds and Antibiotics Modified Gutta-percha (NDGX) for Non-surgical Root Canal Therapy (RCT) Filler Material Recruiting NCT03376984 Phase 2, Phase 3
11 Clinical and Radiographic Evaluation of Calcium Hydroxide and Bi-antibiotic Paste as Anti-microbial Dressing in Revascularization of Non Vital Immature Permanent Anterior Teeth: A Randomized Clinical Trial Not yet recruiting NCT03504332 Phase 3
12 Efficacy of 1% Chlorexidine Gel as Intracanal Medicament in Primary Molar Teeth - a Clinical and Microbiological Study Unknown status NCT00624572 Phase 2 chlorexidine
13 Effect Of Different Lining Materials on Clinical Symptoms of Stepwise Excavation Without Re-enter: Double Blind Randomizd Clinical Trial Unknown status NCT01730287 Phase 2 Control;Calcium Hydroxide;Mineral Trioxide Aggregate(MTA);CEM cement
14 Incidence of Flare-ups and Apical Healing After Single-visit or Two-visits Treatment of Teeth With Necrotic Pulp and Apical Periodontitis After a Two-year Control Period. A Randomised Clinical Trial. Completed NCT02815189 Phase 2 Acetaminophen 325 mg for Flare up
15 Magnetic Resonance Imaging Assessment of Pulp Regeneration Following Regenerative Endodontic Procedures in Mature Teeth Completed NCT03804450 Phase 2
16 Application Success of Photodynamic Therapy and Diode Laser During Endodontic Therapy of Young Permanent Teeth Completed NCT03074136 Phase 2 0.5% Sodium hypochlorite
17 Comparison of the Success Rate of Anesthesia Between Lidocaine 2% and Lidocaine 2% Mixed With 10% Magnesium Sulfate in the Inferior Alveolar Nerve Block in Posterior Teeth With Irreversible Pulpitis Completed NCT03262857 Phase 2 use of magnesium sulfate with lidocaine in inferior alveolar nerve block
18 A Randomized Controlled Clinical Trial of Regenerative Protocols to Treat Immature Necrotic Teeth Active, not recruiting NCT01827098 Phase 2
19 Pulp Therapy in Necrotic Primary Molars Using CTZ Paste and Zinc Oxide-Eugenol Paste - a Randomized Controlled Clinical Trial Active, not recruiting NCT03650036 Phase 2 Pulp Therapy CTZ Paste;Pulp Therapy ZOE Paste
20 Acute Pain Rate of Single Versus Two-visit Root Canal Treatment of Teeth With Necrotic Pulp and Apical Periodontitis: A Multicenter Clinical Trial Enrolling by invitation NCT04115904 Phase 2
21 The Use of Platelet Rich Fibrin in Pulpal and Periodontal Regeneration in Mature Teeth Withdrawn NCT02477358 Phase 1, Phase 2
22 Influence of Foraminal Enlargement on Postoperative Pain in Teeth With Necrotic Pulp and Apical Periodontitis: A Randomized Controlled Trial. Completed NCT02770053 Phase 1
23 Influence of Maintaining Apical Patency on Postoperative Pain in Posterior Teeth With Necrotic Pulp and Apical Periodontitis: A Randomized Controlled Trial. Completed NCT02768285 Phase 1
24 Regeneration of Pulp-Dentin Development in Teeth With Necrotic Pulps and Immature Roots Active, not recruiting NCT01976065 Phase 1 Triple Antibiotic Paste
25 Incidence of Post-Operative Pain After Single Visit Root Canal Treatment in Necrotic Teeth Using Two Different Rotary Systems (Protaper Nex t& Neolix File) Unknown status NCT03059290
26 Evaluation of the Post Treatment Pain After Instrumentation of Root Canals With a Single File Reciprocating (Wave-One Ni Ti File, DENTSPLY Maillefer) or Rotary(One Shape, Micro Mega, France) File System in Patient With Asymptomatic Necrotic Molars Unknown status NCT03301259
27 Revitalization of Young Immature Permanent Teeth With Necrotic Pulps Using Autologous Stem Cells From Human Exfoliated Deciduous Teeth Unknown status NCT01814436
28 Comparison Of The Effect of Adding XP Endo Finisher To The Irrigation Protocol Versus Conventional Irrigation Method On Post-Operative Flare Ups In Necrotic Teeth Unknown status NCT02952326
29 Effect Of Combination of Calcium Hydroxide And Chlorhexidine Gel 2% as Intracanal Medication in Comparison to Calcium Hydroxide Paste as Intracanal Medication on Postoperative Pain And Bacterial Endotoxins in Necrotic Teeth: Unknown status NCT03009006 Chlorhexidine 2% gel - Calcium Hydroxide Paste - Non-Setting;Calcium Hydroxide Paste - Non-Setting
30 Postoperative Pain After Using Reciprocating Motion With Reciproc Files Versus Adaptive Motion With Twisted File Adaptive In Instrumentation Of Necrotic Mandibular Molars: A Randomized Clinical Trial Unknown status NCT03338322
31 Evaluation of Survival of Mature Second Premolar With Periapical Lesion Following Different Regenerative Treatment Protocols Unknown status NCT02915419
32 The Effect of 3D Instrumentation Versus Rotary Instrumentation on Postoperative Pain and Bacterial Reduction in Necrotic Oval Canals: A Randomized Clinical Trial Unknown status NCT03285334
33 Influence of Reciprocating and Rotational Single-file Systems on the Postoperative Pain: A Randomized Clinical Trial. Completed NCT02929511
34 A Comparative Study Between Pulp Revascularization and MTA Apexification in Necrotic Immature Anterior Teeth, A Randomized Controlled Trial Completed NCT03083015
35 Measurement of Bite Force in Humans Completed NCT00223327
36 Treatment Outcome With a Revascularization Protocol Using the Triple Versus Double Antibiotic Paste Completed NCT00881491 Early Phase 1 Double Antibiotic Paste;Triple Antibiotic Paste;Mineral Trioxide Aggregate
37 Postoperative Pain Assessment After Foraminal Enlargement Using Protaper Next and Reciproc File Systems. Completed NCT03380585
38 Postoperative Pain After Endodontic Irrigation Using 1.3% Versus 5.25% Sodium Hypochlorite Completed NCT03792217
39 Comparison of Postoperative Pain After Root Canal Instrumentation Using Reciproc and ProTaper Next in Asymptomatic Necrotic Molars: A Randomized Clinical Trial Completed NCT02946099
40 Incidence of Post-operative Pain After Single-visit Versus Two-visit Root Canal Treatment of Teeth With Necrotic Pulp and Apical Periodontitis Completed NCT03120845
41 Comparative Evaluation of Different File Systems in Postoperative Pain: Randomize Clinical Study Completed NCT03708081
42 Tissue Characterization in Teeth Treated With a Regeneration Protocol Completed NCT00881907 Early Phase 1 Triple Antibiotic Paste;Triple Antibiotic Paste;Triple Antibiotic Paste
43 Antimicrobial Photodynamic Therapy Associated With the Conventional Endodontic Treatment: A Clinical and Molecular Microbiological Study Completed NCT03212729
44 Periapical Healing After One or Two-visits to Endodontic Treatment in Adolescents Patients Completed NCT01312194
45 Clinical and Radiographic Evaluation of Biodentine and Mineral Trioxide Aggregate in Revascularization of Non Vital Immature Permanent Anterior Teeth (Randomized Clinical Study) Completed NCT03589560 Biodentine;Mineral Trioxide Aggregate
46 Cytokine Regulation of Periradicular Pain in Humans Completed NCT00223470
47 Postoperative Pain of Root Canal Therapy With Three Techniques Completed NCT02442388
48 Development of a Model to Evaluate Regenerative Endodontic Techniques Completed NCT00595595
49 Clinical and Microbiological Evaluation of a Series of Clinical Cases of Permanent Teeth With Incomplete Apexogenesis and Traumatic Necrosis, Treated With Double Antimicrobial Paste, Revascularization Procedures, and MTA Completed NCT03112291
50 Effect of Smear Layer on Endodontic Outcome: A Randomized Controlled Trial Completed NCT03277404

Search NIH Clinical Center for Dental Pulp Necrosis

Cochrane evidence based reviews: dental pulp necrosis

Genetic Tests for Dental Pulp Necrosis

Anatomical Context for Dental Pulp Necrosis

MalaCards organs/tissues related to Dental Pulp Necrosis:

40
Bone, Salivary Gland, Testes, Heart, Spleen, Kidney, Liver

Publications for Dental Pulp Necrosis

Articles related to Dental Pulp Necrosis:

(show top 50) (show all 622)
# Title Authors PMID Year
1
The caries process and its effect on the pulp: the science is changing and so is our understanding. 54 61
18565367 2008
2
The caries process and its effect on the pulp: the science is changing and so is our understanding. 54 61
18615983 2008
3
Long-term prognosis of crown-fractured permanent incisors. The effect of stage of root development and associated luxation injury. 54 61
11310111 2000
4
Evaluation of the effect of delayed management of traumatized permanent teeth. 54 61
7499982 1995
5
Resinous adhesive systems differentially affect the expression of cytokines by human monocytes stimulated or not with Streptococcus mutans in vitro. 61
31927406 2020
6
Regenerative Endodontic Treatment as a Biologically Based Approach for Non-Surgical Retreatment of Immature Teeth. 61
31740065 2020
7
Regenerative Endodontic Therapy with Platelet Rich Fibrin: Case Series. 61
31995420 2020
8
Long-term Pulpal and Restorative Outcomes of Pulpotomy in Mature Permanent Teeth. 61
31902641 2020
9
Revascularization and vital pulp therapy in immature molars with necrotic pulp and irreversible pulpitis: A case report with two-year follow-up. 61
31998518 2020
10
Microbiological Aspects of Traumatic Injuries. 61
31623904 2019
11
Microbiological aspects of traumatic injuries. 61
31125490 2019
12
Immunophenotypic quantification of M1 and M2 macrophage polarization in radicular cysts of primary and permanent teeth. 61
31845371 2019
13
Diagnosis and Management of Transverse Root Fractures. 61
31623913 2019
14
Diagnosis and management of transverse root fractures. 61
31112367 2019
15
Treatment of an Acute Apical Abscess in a Patient With Autoimmune Hepatitis Taking Alendronate: A Case Report. 61
31757341 2019
16
Demographic and Clinical Characteristics of 5294 Jaw Cysts: A Retrospective Study of 38 Years. 61
30758760 2019
17
Efficacy of reciprocating and ultrasonic activation of 6% sodium hypochlorite in the reduction of microbial content and virulence factors in teeth with primary endodontic infection. 61
31879958 2019
18
Osteosynthesis of segmental alveolar fractures by internal fixation and the prognosis of the fractures and teeth. 61
31724290 2019
19
Guided endodontics: a case report of maxillary lateral incisors with multiple dens invaginatus. 61
31799166 2019
20
A case report of multiple bilateral dens invaginatus in maxillary anteriors. 61
31799167 2019
21
Evidence-based clinical practice guideline on antibiotic use for the urgent management of pulpal- and periapical-related dental pain and intraoral swelling: A report from the American Dental Association. 61
31668170 2019
22
Evaluation of pulp necrosis of a tooth with extensive restoration in absence of microleakages. 61
31749352 2019
23
[Apical barrier technology to treat chronic apical periodontitis caused by type Ⅱ dens invaginatus: a case report]. 61
31721510 2019
24
Endodontic complications associated with orthodontic temporary anchorage devices: A systematic review of human studies. 61
31621999 2019
25
Clinical outcomes of 79 traumatically intruded permanent teeth in Chinese children and adolescents: A retrospective study. 61
31638331 2019
26
Progressive ossificans fibrodysplasia endodontic management: Case report. 61
31418882 2019
27
[Clinical management and prognosis evaluation of pulp regeneration therapy]. 61
31550780 2019
28
External invasive resorption: Possible coexisting factors and demographic and clinical characteristics. 61
30129090 2019
29
Effect of root canal debridement on inflammatory cytokine levels. 61
30230109 2019
30
Influence of photobiomodulation therapy on root development of rat molars with open apex and pulp necrosis. 61
31460610 2019
31
[Endodontic-periodontal combined therapy for type Ⅲ dens invaginatus in maxillary lateral incisor: a case report]. 61
31512844 2019
32
Effect of Different Concentrations of Sodium Hypochlorite on Outcome of Primary Root Canal Treatment: A Randomized Controlled Trial. 61
30827769 2019
33
Calcific metamorphosis of pulp after extrusive luxation. 61
30480872 2019
34
Development and evaluation of calcium hydroxide-coated, pericardium-based biomembranes for direct pulp capping. 61
30525301 2019
35
Immunological profile of teeth with inflammatory periapical disease from chronic liver disease patients. 61
30091243 2019
36
Biomaterials and Scaffold Design Strategies for Regenerative Endodontic Therapy. 61
31803727 2019
37
Downregulation of miR-224-5p Promotes Migration and Proliferation in Human Dental Pulp Stem Cells. 61
31396530 2019
38
[Outcomes of traumatic dental injuries in children]. 61
31513162 2019
39
Non-surgical Removal of Dens Invaginatus in Maxillary Lateral Incisor Using CBCT: Two-year Follow-up Case Report. 61
31667354 2019
40
Cytokines and chemokines associated with Treg/Th17 response in chronic inflammatory periapical disease. 61
31664358 2019
41
Oral manifestations of sickle cell disease. 61
30631169 2019
42
Genetic Risk of Talon Cusp: Talon Cusp in Five Siblings. 61
31534801 2019
43
Postoperative malocclusion after maxillofacial fracture management: a retrospective case study. 61
30370261 2018
44
Revascularization-associated Intracanal Calcification: A Case Report with an 8-year Review. 61
30487078 2018
45
Regenerative endodontics: a comprehensive review. 61
29777616 2018
46
Continued root maturation despite persistent apical periodontitis of immature permanent teeth after failed regenerative endodontic therapy. 61
29336522 2018
47
Dental Stem Cells: Current research and future applications. 61
30567439 2018
48
Correlation between crestal alveolar bone loss with intracanal bacteria and apical lesion area in necrotic teeth. 61
30025275 2018
49
Cone-beam computed tomographic and histological investigation of regenerative endodontic procedure in an immature mandibular second premolar with chronic apical abscess. 61
29984903 2018
50
Prevotella strains and lactamic resistance gene distribution in different oral environments of children with pulp necrosis. 61
29737548 2018

Variations for Dental Pulp Necrosis

Expression for Dental Pulp Necrosis

Search GEO for disease gene expression data for Dental Pulp Necrosis.

Pathways for Dental Pulp Necrosis

Pathways related to Dental Pulp Necrosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.37 IBSP FGF2 DSPP DMP1 BMP2
2
Show member pathways
11.74 IBSP DSPP DMP1
3 11.19 IBSP DSPP DMP1
4 11.01 TNFSF11 NT5E FGF2
5 10.72 TNFSF11 IBSP BGLAP
6 9.95 TNFSF11 IBSP BGLAP

GO Terms for Dental Pulp Necrosis

Cellular components related to Dental Pulp Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 TNFSF11 MCAM IBSP FGF2 ENG BMP2
2 endoplasmic reticulum lumen GO:0005788 9.46 MEPE DMP1 BGLAP AMELX
3 extracellular region GO:0005576 9.36 TNFSF11 MEPE MCAM LRRC7 IBSP FGF2
4 extracellular matrix GO:0031012 9.26 MEPE DSPP DMP1 AMELX

Biological processes related to Dental Pulp Necrosis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.88 MCAM IBSP ENG BGLAP AMELX
2 extracellular matrix organization GO:0030198 9.76 IBSP FGF2 DSPP DMP1
3 animal organ morphogenesis GO:0009887 9.7 TNFSF11 FGF2 BMP2
4 cellular response to growth factor stimulus GO:0071363 9.61 IBSP BMP2 BGLAP
5 skeletal system development GO:0001501 9.56 MEPE DSPP BMP2 BGLAP
6 positive regulation of collagen biosynthetic process GO:0032967 9.54 ENG AMELX
7 bone development GO:0060348 9.54 TNFSF11 ENG BGLAP
8 endocardial cushion morphogenesis GO:0003203 9.51 ENG BMP2
9 bone mineralization GO:0030282 9.5 IBSP BMP2 BGLAP
10 regulation of osteoclast differentiation GO:0045670 9.49 TNFSF11 BGLAP
11 osteoblast differentiation GO:0001649 9.46 IBSP BMP2 BGLAP AMELX
12 paracrine signaling GO:0038001 9.4 TNFSF11 FGF2
13 ossification GO:0001503 9.35 TNFSF11 DSPP DMP1 BMP2 BGLAP
14 biomineral tissue development GO:0031214 9.1 MEPE IBSP DSPP DMP1 BGLAP AMELX

Molecular functions related to Dental Pulp Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.33 FGF2 BMP2 AMELX
2 integrin binding GO:0005178 9.13 IBSP FGF2 DMP1
3 hydroxyapatite binding GO:0046848 8.62 BGLAP AMELX

Sources for Dental Pulp Necrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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