MCID: DNT006
MIFTS: 45

Dental Pulp Necrosis

Categories: Gastrointestinal diseases, Oral diseases
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Aliases & Classifications for Dental Pulp Necrosis

MalaCards integrated aliases for Dental Pulp Necrosis:

Name: Dental Pulp Necrosis 11 43 14 71 33
Pulp Necrosis 11 53 33
Necrotic Pulp 11 33
Necrosis of the Pulp 11
Dental Pulp Gangrene 33
Putrescent Pulpitis 33
Devitalized Tooth 33
Devitalised Pulp 33
Putrescent Pulp 33
Nonvital Tooth 33
Pulpless Tooth 33
Pulp Gangrene 33
Dead Pulp 33

Classifications:



External Ids:

Disease Ontology 11 DOID:11623
ICD9CM 34 522.1
MeSH 43 D003790
SNOMED-CT 68 196332000
ICD10 31 K04.1
ICD11 33 1192336635
UMLS 71 C0011407

Summaries for Dental Pulp Necrosis

Disease Ontology: 11 A dental pulp disease characterized by death of the pulp tissue.

MalaCards based summary: Dental Pulp Necrosis, also known as pulp necrosis, is related to dental abscess and periodontitis. An important gene associated with Dental Pulp Necrosis is DSPP (Dentin Sialophosphoprotein), and among its related pathways/superpathways are Extracellular matrix organization and Endochondral ossification. The drugs Amoxicillin and Clindamycin have been mentioned in the context of this disorder. Affiliated tissues include bone, skeletal muscle and bone marrow, and related phenotypes are homeostasis/metabolism and immune system

Related Diseases for Dental Pulp Necrosis

Diseases related to Dental Pulp Necrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 136)
# Related Disease Score Top Affiliating Genes
1 dental abscess 31.9 MEPE DMP1
2 periodontitis 30.7 TNFSF11 RUNX2 BGLAP
3 dentinogenesis imperfecta 1 30.5 DSPP DMP1
4 periapical periodontitis 30.3 TNFSF11 RUNX2 IBSP DSPP BGLAP
5 root resorption 30.3 TNFSF11 RUNX2 DSPP DMP1
6 chronic apical periodontitis 30.1 TNFSF11 RUNX2
7 ankylosis 29.5 TNFSF11 RUNX2 IBSP BMP2 BGLAP
8 bone resorption disease 29.5 TNFSF11 RUNX2 IBSP BMP2 BGLAP
9 periapical granuloma 11.2
10 rapidly involuting congenital hemangioma 10.3
11 teeth, supernumerary 10.3 RUNX2 DSPP
12 tooth erosion 10.3 DSPP AMELX
13 root caries 10.3 DSPP AMELX
14 hair whorl 10.3
15 epithelioid trophoblastic tumor 10.2 MCAM AMELX
16 diamond-blackfan anemia 6 10.2 IBSP BMP2
17 sclerosteosis 1 10.2 DMP1 BGLAP
18 dental fluorosis 10.2 BGLAP AMELX
19 diffuse idiopathic skeletal hyperostosis 10.2 BMP2 BGLAP
20 hypercementosis 10.2 IBSP DSPP AMELX
21 ossification of the posterior longitudinal ligament of spine 10.1 RUNX2 BMP2 BGLAP
22 hypophosphatasia 10.1 RUNX2 DSPP BGLAP
23 exostosis 10.1 RUNX2 BMP2 BGLAP
24 spondylometaphyseal dysplasia with corneal dystrophy 10.1 NT5E ENG
25 hyperphosphatemia 10.1 RUNX2 BMP2 BGLAP
26 dental pulp calcification 10.1 IBSP DSPP BMP2 AMELX
27 angiodysplasia 10.1 FGF2 ENG
28 saethre-chotzen syndrome 10.1 RUNX2 IBSP BGLAP
29 sickle cell anemia 10.1
30 deficiency anemia 10.1
31 autosomal recessive hypophosphatemic rickets 10.1 MEPE DSPP DMP1
32 arterial calcification of infancy 10.1 RUNX2 NT5E DMP1
33 hypophosphatemic rickets, x-linked recessive 10.1 MEPE DSPP DMP1
34 meckel syndrome, type 7 10.0 TNFSF11 BGLAP
35 ataxia with vitamin e deficiency 10.0
36 48,xxxy syndrome 10.0
37 48,xxyy syndrome 10.0
38 48,xyyy 10.0
39 chronic recurrent multifocal osteomyelitis 10.0 TNFSF11 BMP2 BGLAP
40 endosteal hyperostosis, autosomal dominant 10.0 TNFSF11 IBSP BMP2
41 multicentric carpotarsal osteolysis syndrome 10.0 TNFSF11 IBSP BGLAP
42 crouzon syndrome 10.0 RUNX2 FGF2 BGLAP
43 fibrous dysplasia 10.0 TNFSF11 IBSP BGLAP
44 osteopetrosis, autosomal dominant 2 10.0 TNFSF11 BGLAP
45 osteoglophonic dysplasia 10.0 MEPE DMP1
46 enchondromatosis, multiple, ollier type 10.0 TNFSF11 RUNX2 BMP2
47 cardiomyopathy, familial restrictive, 3 10.0 BMP7 BMP2
48 inflammatory bowel disease 14 10.0 THY1 NT5E
49 dental caries 10.0 IBSP DSPP DMP1 BMP2 AMELX
50 sexual masochism 10.0 ENG BMP7

Graphical network of the top 20 diseases related to Dental Pulp Necrosis:



Diseases related to Dental Pulp Necrosis

Symptoms & Phenotypes for Dental Pulp Necrosis

MGI Mouse Phenotypes related to Dental Pulp Necrosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.18 AMELX BGLAP BMP2 BMP7 DMP1 DSPP
2 immune system MP:0005387 10.03 AMELX BGLAP BMP2 BMP7 DMP1 DSPP
3 craniofacial MP:0005382 10.02 AMELX BMP2 BMP7 DMP1 DSPP ENG
4 limbs/digits/tail MP:0005371 9.98 BMP2 BMP7 DMP1 ENG IBSP RUNX2
5 digestive/alimentary MP:0005381 9.91 AMELX BMP2 BMP7 DSPP ENG IBSP
6 skeleton MP:0005390 9.77 AMELX BGLAP BMP2 BMP7 DMP1 DSPP
7 respiratory system MP:0005388 9.7 AMELX BMP7 DSPP ENG RUNX2 THY1
8 hematopoietic system MP:0005397 9.44 AMELX BGLAP BMP2 BMP7 DMP1 ENG

Drugs & Therapeutics for Dental Pulp Necrosis

Drugs for Dental Pulp Necrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 105)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
2
Clindamycin Approved, Vet_approved Phase 4 18323-44-9, 24729-96-2 29029
3
Sodium citrate Approved, Investigational Phase 4 68-04-2 23431961
4
Clavulanic acid Approved, Vet_approved Phase 4 58001-44-8 5280980
5
Lactitol Approved, Investigational Phase 4 585-86-4, 585-88-6 157355 493591
6
Ethanol Approved Phase 4 64-17-5 702
7
Xylometazoline Approved, Investigational Phase 4 526-36-3 5709
8
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
9
Cefixime Approved, Investigational Phase 4 79350-37-1 5362065
10
Simvastatin Approved Phase 4 79902-63-9 54454
11
Racepinephrine Approved, Vet_approved Phase 4 51-43-4, 329-65-7 838 5816
12
Citric acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
13
Clindamycin phosphate Phase 4 32603
14 Clindamycin palmitate Phase 4
15 Citrate Phase 4
16 beta-Lactamase Inhibitors Phase 4
17 Amoxicillin-Potassium Clavulanate Combination Phase 4
18 Anesthetics Phase 4
19 Antibiotics, Antitubercular Phase 4
20 Vasoconstrictor Agents Phase 4
21 Hormones Phase 4
22 Epinephryl borate Phase 4
23 Carticaine Phase 4
24
Thrombin Approved, Investigational Phase 2, Phase 3
25 Anti-Infective Agents Phase 2, Phase 3
26
Sodium Hypochlorite Phase 2, Phase 3
27 Eusol Phase 2, Phase 3
28 Bee Products Phase 2, Phase 3
29 Propolis Phase 2, Phase 3
30 Disinfectants Phase 2, Phase 3
31 Root Canal Irrigants Phase 2, Phase 3
32 Horseradish Tree Phase 2, Phase 3
33
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
34
Clotrimazole Approved, Vet_approved Phase 2 23593-75-1 2812
35
Acetaminophen Approved Phase 2 103-90-2 1983
36
Lidocaine Approved, Vet_approved Phase 2 137-58-6 3676
37
Ibuprofen Approved Phase 2 15687-27-1 3672
38
Polihexanide Approved, Investigational Phase 2 28757-47-3 20977
39
Tetracycline Approved, Vet_approved Phase 1, Phase 2 60-54-8 5353990
40
Eugenol Approved Phase 1, Phase 2 97-53-0 3314
41
Chloramphenicol Approved, Vet_approved Phase 1, Phase 2 56-75-7 298 5959
42
Zinc oxide Approved Phase 1, Phase 2 1314-13-2
43
Zinc cation Approved, Experimental, Investigational Phase 1, Phase 2 7440-66-6, 23713-49-7 32051
44
Methylthioninium Approved, Experimental, Investigational Phase 1, Phase 2 61-73-4, 7060-82-4 6099
45 Cytochrome P-450 CYP3A Inhibitors Phase 2
46 Antifungal Agents Phase 2
47 Hormone Antagonists Phase 2
48 Antirheumatic Agents Phase 2
49 Anti-Inflammatory Agents, Non-Steroidal Phase 2
50 Analgesics, Non-Narcotic Phase 2

Interventional clinical trials:

(show top 50) (show all 81)
# Name Status NCT ID Phase Drugs
1 Effect of Irrigation With Antibiotic-containing Solutions Versus Sodium Hypochlorite on Postoperative Pain and Intra-canal Bacteria in Teeth With Necrotic Pulps (a Randomized Double-blind Clinical Trial) Unknown status NCT04035070 Phase 4
2 Efficiency of Triple Antibiotic Mixture and Propolis as Intracanal Medication in Revascularization Process in Immature Apex: A Clinical Study Completed NCT03533231 Phase 4
3 Evaluation of Postoperative Pain After Using 3MIX-TATIN Versus Calcium Hydroxide Iodoform Paste In Necrotic Primary Molars Treated by Lesion Sterilization and Tissue Repair Therapy: A Randomized Controlled Trial Completed NCT03084601 Phase 4 Calcium Hydroxide, Iodoform, paste;3-mixtatin
4 Assessment of Postoperative Pain After Using Silver Nanoparticles With and Without Calcium Hydroxide as an Intracanal Medication in Patients With Necrotic Pulp: (A Randomized Clinical Trial) Completed NCT03692286 Phase 4 Silver Nanoparticles in gel form;Calcium Hydroxide Intracanal medication
5 Revascularisation Versus Mineral Trioxide Aggregate in the Management of Non-Vital Immature Permanent Incisors in a Young Population: A Randomised Controlled Trial (Pilot Study) Completed NCT01817413 Phase 4
6 Assessment of Postoperative Pain After Using Two Formulations of Calcium Hydroxide Intracanal Medication : A Randomized Clinical Trial. Recruiting NCT05021809 Phase 4 Calcium hydroxide intracanal medication application
7 Clinical and Radiographic Evaluation of Calcium Hydroxide and Bi-antibiotic Paste as Anti-microbial Dressing in Revascularization of Non Vital Immature Permanent Anterior Teeth: A Randomized Clinical Trial Unknown status NCT03504332 Phase 3
8 Assessment of a New Apexification Method for Patients Presenting a Non Vital Immature Tooth Completed NCT00472173 Phase 3 Mineral Trioxide Aggregate;Calcium hydroxide
9 Enhancement of Apexification Procedure Outcome of Non Vital Incompletely Formed Roots Using Apical Matrix Completed NCT03849222 Phase 2, Phase 3 MTA;Ca(OH)2;Apical matrix
10 Transplantation of Allogeneic Mesenchymal Stromal Cells in Patients With Immature Apex Teeth With Pulp Necrosis and Chronic Apical Periodontitis Completed NCT04545307 Phase 2, Phase 3
11 Nanodiamonds and Antibiotics Modified Gutta-percha (NDGX) for Non-surgical Root Canal Therapy (RCT) Filler Material Recruiting NCT03376984 Phase 2, Phase 3
12 Effect Of Propolis Nanoparticles Versus Sodium Hypochlorite As Root Canal Irrigant On Postoperative Pain And Bacterial Reduction In Mandibular Premolars With Necrotic Pulps (A Randomized Clinical Trial) Not yet recruiting NCT05146713 Phase 2, Phase 3 sodium hypochlorite
13 Assessment of 3 Different Root Canal Obturating Sealers on Postoperative Pain and Swelling in Single Canal Necrotic Teeth With a Single Visit .a Randomized Controlled Trial Not yet recruiting NCT05419752 Phase 2, Phase 3 bioceramic sealer;MTA;resin sealer
14 Effect of Moringa Oleifera Leaf Extract Versus Sodium Hypochlorite as Root Canal Irrigant on Postoperative Pain and Bacterial Reduction in Mandibular Premolars With Necrotic Pulps: A Randomized Clinical Trial Not yet recruiting NCT05348824 Phase 2, Phase 3 Sodium hypochlorite
15 Effect Of Different Lining Materials on Clinical Symptoms of Stepwise Excavation Without Re-enter: Double Blind Randomizd Clinical Trial Unknown status NCT01730287 Phase 2 Control;Calcium Hydroxide;Mineral Trioxide Aggregate(MTA);CEM cement
16 Efficacy of 1% Chlorexidine Gel as Intracanal Medicament in Primary Molar Teeth - a Clinical and Microbiological Study Unknown status NCT00624572 Phase 2 chlorexidine
17 Acute Pain Rate of Single Versus Two-visit Root Canal Treatment of Teeth With Necrotic Pulp and Apical Periodontitis: A Multicenter Clinical Trial Unknown status NCT04115904 Phase 2
18 Pulp Therapy in Necrotic Primary Molars Using CTZ Paste and Zinc Oxide-Eugenol Paste - a Randomized Controlled Clinical Trial Completed NCT03650036 Phase 2 Pulp Therapy CTZ Paste;Pulp Therapy ZOE Paste
19 Efficacy of Combined Blood Clot and Platelet Rich Fibrin Scaffolds in Regeneration of Necrotic Immature Permanent Teeth (A Randomized Controlled Clinical Trial) Completed NCT04390854 Phase 2
20 Magnetic Resonance Imaging Assessment of Pulp Regeneration Following Regenerative Endodontic Procedures in Mature Teeth Completed NCT03804450 Phase 2
21 Incidence of Flare-ups and Apical Healing After Single-visit or Two-visits Treatment of Teeth With Necrotic Pulp and Apical Periodontitis After a Two-year Control Period. A Randomised Clinical Trial. Completed NCT02815189 Phase 2 Acetaminophen 325 mg for Flare up
22 Comparison of Antimicrobial Action of Sodium Hypochlorite and Polyhexamethylene Biguanide as Root Canal Irrigants in Patients Reporting With Non-vital Necrotic Pulp and Apical Periodontitis Enrolling by invitation NCT05306431 Phase 2 Polyhexamethylene biguanide;Sodium Hypochlorite
23 Effectiveness of Antimicrobial Photodynamic Therapy, Guedes-Pinto Paste and CTZ Paste for Endodontic Treatment of Deciduous Teeth - Study Protocol for a Randomized Controlled Clinical Trial Not yet recruiting NCT04587089 Phase 1, Phase 2
24 Microbiological Evaluation of Single Versus Multiple Visits Regeneration Using MALDI-TOF Mass Spectrometry (A Randomized Controlled Clinical Trial) Terminated NCT04533074 Phase 2
25 Influence of Maintaining Apical Patency on Postoperative Pain in Posterior Teeth With Necrotic Pulp and Apical Periodontitis: A Randomized Controlled Trial. Completed NCT02768285 Phase 1
26 Influence of Foraminal Enlargement on Postoperative Pain in Teeth With Necrotic Pulp and Apical Periodontitis: A Randomized Controlled Trial. Completed NCT02770053 Phase 1
27 Regeneration of Pulp-Dentin Development in Teeth With Necrotic Pulps and Immature Roots Active, not recruiting NCT01976065 Phase 1 Triple Antibiotic Paste
28 Assessment of Antimicrobial Efficacy of Nano Chitosan, Chlorhexidine, Chlorhexidine/ Nano Chitosan Combination Versus Sodium Hypochlorite Irrigation in Patients With Necrotic Mandibular Posterior Teeth: A Randomized Clinical Trial Unknown status NCT03668899
29 Revitalization of Young Immature Permanent Teeth With Necrotic Pulps Using Autologous Stem Cells From Human Exfoliated Deciduous Teeth Unknown status NCT01814436
30 Chitosan,Chitosan Nanoparticles,and Chlorhexidine Gluconate, as Intra Canal Medicaments in Primary Teeth: An In-vivo Study Unknown status NCT03588351 chitosan nanoparticles gel;chitosan gel;chlorhexidine gluconate
31 Effect Of Combination of Calcium Hydroxide And Chlorhexidine Gel 2% as Intracanal Medication in Comparison to Calcium Hydroxide Paste as Intracanal Medication on Postoperative Pain And Bacterial Endotoxins in Necrotic Teeth: Unknown status NCT03009006 Chlorhexidine 2% gel - Calcium Hydroxide Paste - Non-Setting;Calcium Hydroxide Paste - Non-Setting
32 The Frequency Of Sodium Hypochlorite Extrusion During Endodontic Treatments: A Clinical Study Unknown status NCT04262362
33 Assessment of Regenerative Potential of Mature Permanent Teeth With Necrotic Pulps Using Two Revascularization Protocols. (In Vivo Study) Unknown status NCT04158232
34 Evaluation of the Antimicrobial Effect of Pre-synthesized Novel Antibiotic Electrospun Nanofibers as an Intracanal Delivery Strategy for Regenerative Endodontics A Randomized Clinical Trial Unknown status NCT03690960
35 Evaluation of Success Rate of Non Vital Mature Anterior Teeth With Periapical Lesion Following Single Versus Two Visit Regenerative Treatment Protocol A Randomized Clinical Study Unknown status NCT03717337
36 Evaluation of the Post Treatment Pain After Instrumentation of Root Canals With a Single File Reciprocating (Wave-One Ni Ti File, DENTSPLY Maillefer) or Rotary(One Shape, Micro Mega, France) File System in Patient With Asymptomatic Necrotic Molars Unknown status NCT03301259
37 Effect of Using Etidronate in Sodium Hypochlorite Versus Sodium Hypochlorite Irrigating Solution on the Intensity of Postoperative Pain and Bacterial Load Reduction in Patients With Necrotic Pulp: A Randomized Clinical Trial Unknown status NCT04035330
38 Evaluation of Post-operative Pain and Bacterial Reduction Following Laser Activated Irrigation Versus Passive Ultrasonic Irrigation in Necrotic Single Rooted Teeth: A Randomized Clinical Trial Unknown status NCT04035083
39 Evaluation of Post-Operative Pain After Regenerative Endodontic Using Photo-Activated Oral Disinfection Versus Triple-Antibiotic Paste for Management of Necrotic Young Permanent Anterior Teeth Unknown status NCT03763110 antibiotic paste
40 Evaluation of the Efficacy of Injectable Platelet-Rich Fibrin Versus Platelet-Rich Plasma in the Regeneration of Necrotic Immature Maxillary Anterior Teeth. (A Randomized Clinical Trial) Unknown status NCT03698188
41 Incidence of Post-Operative Pain After Single Visit Root Canal Treatment in Necrotic Teeth Using Two Different Rotary Systems (Protaper Nex t& Neolix File) Unknown status NCT03059290
42 Comparison Of The Effect of Adding XP Endo Finisher To The Irrigation Protocol Versus Conventional Irrigation Method On Post-Operative Flare Ups In Necrotic Teeth Unknown status NCT02952326
43 Clinical and Radiographic Evaluation of Neo MTA Versus Conventional White MTA in Revascularization of Non-Vital Immature Permanent Anterior Teeth: A Randomized Controlled Trial Unknown status NCT03545139 Early Phase 1
44 Nanodiamond Modified Gutta Percha (NDGP) Composite for Non-surgical Root Canal Therapy (RCT) Filler Material Applied by Vertical Condensation Obturation Procedure Completed NCT02698163
45 Comparison of Postoperative Pain After Root Canal Instrumentation Using Reciproc and ProTaper Next in Asymptomatic Necrotic Molars: A Randomized Clinical Trial Completed NCT02946099
46 Influence of Reciprocating and Rotational Single-file Systems on the Postoperative Pain: A Randomized Clinical Trial. Completed NCT02929511
47 Postoperative Pain After Endodontic Irrigation Using 1.3% Versus 5.25% Sodium Hypochlorite Completed NCT03792217
48 Measurement of Bite Force in Humans Completed NCT00223327
49 Digitized Assessment for the Survival of Mature Anterior Teeth With Periapical Lesion After One Step Regenerative Approach Using Different Asepsis Maneuvers Completed NCT03652129
50 Postoperative Pain Assessment After Foraminal Enlargement Using Protaper Next and Reciproc File Systems. Completed NCT03380585

Search NIH Clinical Center for Dental Pulp Necrosis

Cochrane evidence based reviews: dental pulp necrosis

Genetic Tests for Dental Pulp Necrosis

Anatomical Context for Dental Pulp Necrosis

Organs/tissues related to Dental Pulp Necrosis:

MalaCards : Bone, Skeletal Muscle, Bone Marrow, Monocytes, Heart, Spleen, Kidney

Publications for Dental Pulp Necrosis

Articles related to Dental Pulp Necrosis:

(show top 50) (show all 1385)
# Title Authors PMID Year
1
The caries process and its effect on the pulp: the science is changing and so is our understanding. 53 62
18565367 2008
2
The caries process and its effect on the pulp: the science is changing and so is our understanding. 53 62
18615983 2008
3
Long-term prognosis of crown-fractured permanent incisors. The effect of stage of root development and associated luxation injury. 53 62
11310111 2000
4
Evaluation of the effect of delayed management of traumatized permanent teeth. 53 62
7499982 1995
5
Silver diamine fluoride therapy for dental care. 62
36097560 2022
6
Microbiome Changes during Regenerative Endodontic Treatment Using Different Methods of Disinfection. 62
36030971 2022
7
Inflammation down regulates stromal cell-derived factor 1α in the early phase of pulpitis. 62
35930964 2022
8
Comparative Evaluation of Postoperative Pain in Primary Teeth Obturated With Zinc Oxide Eugenol versus Metapex: A Randomized Clinical Trial. 62
36189565 2022
9
Effect of systemic antibiotic therapy on pulp repair following extrusive luxation and avulsion in a murine model: A histomorphological study. 62
35662418 2022
10
Treatment Outcomes of Regenerative Endodontic Procedures in Traumatized Immature Permanent Necrotic Teeth: A Retrospective Study. 62
35398440 2022
11
Characteristics of Cracked Teeth with Reversible Pulpitis After Orthodontic Banding-A Prospective Cohort Study. 62
36150561 2022
12
The paediatric dentistry-restorative dentistry interface. 62
36151172 2022
13
Preoperative factors analysis on root development after regenerative endodontic procedures: a retrospective study. 62
36058906 2022
14
Survival analysis of fragment reattachments and direct composite restorations in permanent teeth after dental traumatic injuries. 62
36116107 2022
15
Effectiveness of root canal treatment for vital pulps compared with necrotic pulps in the presence or absence of signs of periradicular pathosis: A systematic review and meta-analysis. 62
36107038 2022
16
Review of guidance for the selection of regenerative endodontics, apexogenesis, apexification, pulpotomy, and other endodontic treatments for immature permanent teeth. 62
35929348 2022
17
Persistent pain after successful endodontic treatment in a patient with Wegener's granulomatosis: a case report. 62
36090516 2022
18
Prevalence of sequelae after traumatic dental injuries to anterior primary teeth: A systematic review and meta-analysis. 62
35276019 2022
19
Generalized pulp canal obliteration in a patient on long-term glucocorticoids: a case report and literature review. 62
35971099 2022
20
Radiographic outcomes and prognostic factors in nonvital immature permanent teeth after apexification with modified calcium hydroxide paste: a retrospective study. 62
35399138 2022
21
Self-revascularization Following Horizontal Root Fracture with Lateral Luxation Injury in a Permanent Maxillary Central Incisor. 62
36110591 2022
22
Effectiveness of endodontic tissue engineering in treatment of apical periodontitis: A systematic review. 62
35699668 2022
23
Letter to the editor related to recently published systematic review "What is the best long term treatment modality for immature permanent teeth with pulp necrosis and apical periodontitis?" 62
35298830 2022
24
[Comparative study on the effect of microscopic revascularization and apexification in the treatment of pulp necrosis of permanent teeth]. 62
36204965 2022
25
Clinical Condition of the Oral Cavity in the Adult Polish Population below 70 Years of Age after Myocardial Infarction-A Case-Control Study. 62
35742511 2022
26
Ten-year follow up of previously traumatized immature permanent incisors sustaining second and third traumatic injuries after revascularization treatment: Case reports. 62
35766130 2022
27
Chronic systemic corticosteroid therapy influences the development of pulp necrosis and experimental apical periodontitis, exacerbating the inflammatory process and bone resorption in rats. 62
35278220 2022
28
Regenerative Endodontic Procedure in an Immature Permanent Incisor with Internal Root Resorption: a Case Report. 62
35783498 2022
29
Head and neck radiotherapy effects on the dental pulp vitality and response to sensitivity tests: A systematic review with meta-analysis. 62
35298027 2022
30
Dental Pulp Regeneration Induced by Allogenic Mesenchymal Stromal Cell Transplantation in a Mature Tooth: A Case Report. 62
35307516 2022
31
Deciduous Tooth Pulp Autotransplantation for the Regenerative Endodontic Treatment of Permanent Teeth With Pulp Necrosis: A Case Series. 62
35114270 2022
32
Clinical and radiographic outcomes of regenerative endodontic treatment performed by endodontic postgraduate students: a retrospective study. 62
35692225 2022
33
Effectiveness of revitalization in treating apical periodontitis: A systematic review and meta-analysis. 62
35579093 2022
34
Lateral luxation: Is root resorption an unavoidable complication? 62
35600017 2022
35
Effect of silver diamine fluoride on vital dental pulp: A systematic review. 62
35139409 2022
36
A retrospective study on the long-term outcomes of pulpectomy and influencing factors in primary teeth. 62
35756771 2022
37
Regenerative endodontic procedures for two traumatized mature anterior teeth with transverse root fractures. 62
35413867 2022
38
A critical analysis of clinical research methods to study regenerative endodontics. 62
35338660 2022
39
The effect of photodynamic therapy on postoperative pain in teeth with primary endodontic infection. 62
34954090 2022
40
Efficacy of Ciprofloxacin, Metronidazole and Minocycline in Ordered Mesoporous Silica against Enterococcus faecalis for Dental Pulp Revascularization: An In-Vitro Study. 62
35329718 2022
41
Analysis and Assessment of Pulp Vitality of 102 Intrinsically Stained Teeth in Dogs. 62
34825611 2022
42
Schwann cell-derived EVs facilitate dental pulp regeneration through endogenous stem cell recruitment via SDF-1/CXCR4 axis. 62
34852303 2022
43
Photobiomodulation therapy and endodontic treatment of teeth with apical periodontitis using 940-nm diode laser. Report of two cases. 62
35317289 2022
44
Evaluation of Complete Pulpotomy With Biodentine on Mature Permanent Molars With Signs and Symptoms of Symptomatic Irreversible Pulpitis: 12-months Follow-up. 62
34974080 2022
45
The effect of changing apical foramen diameter on regenerative potential of mature teeth with necrotic pulp and apical periodontitis. 62
34480644 2022
46
[Application of cold flowable gutta-percha in root canal obturation after apexification]. 62
35165471 2022
47
Prevalence of Fungi in Primary Endodontic Infections of a Greek-living Population Through Real-time Polymerase Chain Reaction and Matrix-assisted Laser Desorption/Ionization Time-of-flight Mass Spectrometry. 62
34800484 2022
48
Pulpitis in a dens invaginatus presenting as a Trigeminal Neuralgia: A case report. 62
35173907 2022
49
Pulpal and Periapical Status of the Vital Teeth Used as Abutment for Fixed Prosthesis-A Systematic Review and Meta-Analysis. 62
34516686 2022
50
Prognosis of primary teeth following intrusive luxation according to the degree of intrusion: A retrospective cohort study. 62
34165860 2022

Variations for Dental Pulp Necrosis

Expression for Dental Pulp Necrosis

Search GEO for disease gene expression data for Dental Pulp Necrosis.

Pathways for Dental Pulp Necrosis

GO Terms for Dental Pulp Necrosis

Cellular components related to Dental Pulp Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 TNFSF11 THY1 MEPE MCAM IBSP FGF2

Biological processes related to Dental Pulp Necrosis according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 10.35 AMELX BGLAP ENG IBSP MCAM THY1
2 positive regulation of gene expression GO:0010628 10.3 BMP2 BMP7 ENG FGF2 RUNX2 TNFSF11
3 chondrocyte differentiation GO:0002062 10.09 RUNX2 BMP2 AMELX
4 bone mineralization GO:0030282 10.07 IBSP BMP2 BGLAP
5 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 10.06 ENG BMP7 BMP2
6 BMP signaling pathway GO:0030509 10.06 BMP2 BMP7 ENG RUNX2
7 cell population proliferation GO:0008283 10.05 RUNX2 FGF2 CEMP1 BMP7
8 animal organ morphogenesis GO:0009887 10.04 TNFSF11 FGF2 BMP7 BMP2
9 cellular response to growth factor stimulus GO:0071363 10.03 IBSP BMP2 BGLAP
10 positive regulation of osteoblast differentiation GO:0045669 10.03 RUNX2 FGF2 BMP7 BMP2
11 SMAD protein signal transduction GO:0060395 10.02 RUNX2 BMP7 BMP2
12 stem cell differentiation GO:0048863 9.97 BGLAP FGF2 RUNX2
13 cellular response to BMP stimulus GO:0071773 9.97 RUNX2 BMP7 BMP2
14 odontogenesis of dentin-containing tooth GO:0042475 9.97 RUNX2 BMP7 BMP2 AMELX
15 skeletal system development GO:0001501 9.97 BGLAP BMP2 BMP7 MEPE RUNX2
16 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus GO:1901522 9.95 RUNX2 BMP2
17 bone development GO:0060348 9.95 TNFSF11 ENG BMP2 BGLAP
18 endocardial cushion formation GO:0003272 9.94 BMP7 BMP2
19 positive regulation of epithelial cell differentiation GO:0030858 9.94 BMP7 BMP2
20 mesenchymal cell differentiation GO:0048762 9.93 BMP2 BMP7
21 osteoblast differentiation GO:0001649 9.93 AMELX BGLAP BMP2 FGF2 IBSP RUNX2
22 regulation of odontogenesis of dentin-containing tooth GO:0042487 9.91 RUNX2 BMP2
23 paracrine signaling GO:0038001 9.9 TNFSF11 FGF2
24 thyroid-stimulating hormone-secreting cell differentiation GO:0060129 9.86 FGF2 BMP2
25 epithelial to mesenchymal transition GO:0001837 9.86 ENG BMP7 BMP2 AMELX
26 mesenchyme development GO:0060485 9.85 BMP7 BMP2
27 ameloblast differentiation GO:0036305 9.84 BMP7 BMP2
28 regulation of osteoclast differentiation GO:0045670 9.83 TNFSF11 BGLAP
29 atrioventricular canal morphogenesis GO:1905222 9.81 ENG BMP2
30 corticotropin hormone secreting cell differentiation GO:0060128 9.78 FGF2 BMP2
31 ossification GO:0001503 9.7 TNFSF11 RUNX2 IBSP DMP1 BMP7 BMP2
32 biomineral tissue development GO:0031214 9.4 MEPE IBSP DSPP DMP1 CEMP1 BGLAP

Molecular functions related to Dental Pulp Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.86 TNFSF11 FGF2 BMP7 BMP2
2 growth factor activity GO:0008083 9.76 FGF2 BMP7 BMP2 AMELX
3 integrin binding GO:0005178 9.56 THY1 IBSP FGF2 DMP1
4 hydroxyapatite binding GO:0046848 9.1 CEMP1 BGLAP AMELX

Sources for Dental Pulp Necrosis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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