MCID: DNT006
MIFTS: 33

Dental Pulp Necrosis

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Dental Pulp Necrosis

MalaCards integrated aliases for Dental Pulp Necrosis:

Name: Dental Pulp Necrosis 12 44 15 73
Pulp Necrosis 12 55
Necrosis of the Pulp 12
Necrotic Pulp 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11623
ICD10 33 K04.1
ICD9CM 35 522.1
MeSH 44 D003790
SNOMED-CT 68 42711005
UMLS 73 C0011407

Summaries for Dental Pulp Necrosis

MalaCards based summary : Dental Pulp Necrosis, also known as pulp necrosis, is related to periapical periodontitis and periodontitis. An important gene associated with Dental Pulp Necrosis is DSPP (Dentin Sialophosphoprotein). The drugs Ciprofloxacin and Cefixime have been mentioned in the context of this disorder. Affiliated tissues include bone.

Wikipedia : 76 Pulp necrosis is a clinical diagnostic category indicating the death of cells and tissues in the pulp... more...

Related Diseases for Dental Pulp Necrosis

Graphical network of the top 20 diseases related to Dental Pulp Necrosis:



Diseases related to Dental Pulp Necrosis

Symptoms & Phenotypes for Dental Pulp Necrosis

Drugs & Therapeutics for Dental Pulp Necrosis

Drugs for Dental Pulp Necrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 111)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 1,Early Phase 1,Not Applicable 85721-33-1 2764
2
Cefixime Approved, Investigational Phase 4 79350-37-1 5362065 54362
3
Metronidazole Approved Phase 4,Phase 3,Phase 1,Early Phase 1,Not Applicable 443-48-1 4173
4
Simvastatin Approved Phase 4 79902-63-9 54454
5
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
6
Xylometazoline Approved, Investigational Phase 4 526-36-3 5709
7
Ethanol Approved Phase 4,Phase 2 64-17-5 702
8
Zinc Approved, Investigational Phase 4,Phase 2,Phase 1,Early Phase 1,Not Applicable 7440-66-6
9
Neomycin Approved, Vet_approved Phase 4,Phase 1,Early Phase 1 1404-04-2 8378
10
Bacitracin Approved, Vet_approved Phase 4,Phase 1,Early Phase 1 1405-87-4 10909430 439542
11
Chlorhexidine Approved, Vet_approved Phase 4,Phase 2,Not Applicable 55-56-1 2713 9552079
12
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
13
Salicylic acid Approved, Investigational, Vet_approved Phase 4 69-72-7 338
14
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
15
Ceftibuten Approved, Investigational Phase 4 97519-39-6 5282241 5282242
16
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
17
Chloramphenicol Approved, Vet_approved Phase 4,Phase 2 56-75-7 5959 298
18
Eugenol Approved Phase 4,Phase 2,Not Applicable 97-53-0 3314
19
Tetracycline Approved, Vet_approved Phase 4,Phase 2 60-54-8 5353990
20
Zinc oxide Approved Phase 4,Phase 2,Not Applicable 1314-13-2
21
Lactitol Investigational Phase 4 585-86-4 3871
22
Chloramphenicol succinate Experimental Phase 4,Phase 2 3544-94-3
23 Bone Density Conservation Agents Phase 4,Phase 3,Phase 2,Not Applicable
24 Calcium, Dietary Phase 4,Phase 3,Phase 2,Not Applicable
25 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
26 Propolis Phase 4
27 Antiprotozoal Agents Phase 4,Phase 1,Early Phase 1
28 Topoisomerase Inhibitors Phase 4,Phase 1,Early Phase 1
29 Bacitracin zinc, neomycin sulfate, polymyxin B, drug combination Phase 4,Phase 1,Early Phase 1
30 Polymyxins Phase 4,Phase 1,Early Phase 1
31 Pharmaceutical Solutions Phase 4,Phase 2,Not Applicable
32 Polymyxin B Phase 4,Phase 1,Early Phase 1
33 Vasoconstrictor Agents Phase 4
34 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 1,Early Phase 1
35 Antiparasitic Agents Phase 4,Phase 1,Early Phase 1
36 Anti-Infective Agents, Local Phase 4,Phase 1,Early Phase 1,Not Applicable
37 Anesthetics Phase 4,Phase 2,Phase 1,Not Applicable
38 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 1,Early Phase 1
39 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable
40 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable
41 Antitubercular Agents Phase 4,Phase 1,Early Phase 1,Not Applicable
42 Bee Products Phase 4
43 Hormone Antagonists Phase 4
44 Peripheral Nervous System Agents Phase 4,Phase 2,Not Applicable
45 glucocorticoids Phase 4
46 Autonomic Agents Phase 4
47 Antineoplastic Agents, Hormonal Phase 4
48 Chlorhexidine gluconate Phase 4,Phase 2,Not Applicable
49 Hormones Phase 4
50 HIV Protease Inhibitors Phase 4

Interventional clinical trials:

(show top 50) (show all 70)
# Name Status NCT ID Phase Drugs
1 Evaluation of Postoperative Pain After Using 3MIX-TATIN Versus Calcium Hydroxide Iodoform Paste In Necrotic Primary Molars Treated by Lesion Sterilization and Tissue Repair Therapy Completed NCT03084601 Phase 4 Calcium Hydroxide, Iodoform, paste;3-mixtatin
2 Efficiency of Triple Antibiotic Paste, Ciprofloxacin/Propolis, Ciprofloxacin/Metronidazole, Propolis/Metronidazole Combinations on Revascularization Process of Immature Necrotic Maxillary Incisors of Patients 8-18 Years Old. Completed NCT03533231 Phase 4
3 Effect of Topical Dexamethasone on Histologic Response of Human Dental Pulp Completed NCT02574468 Phase 4 Dexamethasone applied on pulp or Dexamethasone did not applied on pulp
4 Antimicrobial Pulpotomy of Primary Molars Completed NCT01010451 Phase 4
5 Comparison of Two Dental Techniques Used to Treat Teeth Which Have Become Infected or Painful Following Trauma Completed NCT01817413 Phase 4
6 Assessment of Postoperative Pain After Using Various Intracanal Medication in Patients With Necrotic Pulp Not yet recruiting NCT03692286 Phase 4 Silver Nanoparticles in gel form;Calcium Hydroxide Intracanal medication
7 Assessment of a New Apexification Method for Patients Presenting a Non Vital Immature Tooth Completed NCT00472173 Phase 3 Mineral Trioxide Aggregate;Calcium hydroxide
8 Nanodiamond-Gutta Percha Composite Biomaterials for Root Canal Therapy Recruiting NCT03376984 Phase 2, Phase 3
9 Revascularization of Immature Anterior Necrotic Teeth Not yet recruiting NCT03504332 Phase 3
10 Efficacy of Chlorexidine as Intracanal Medicament in Primary Teeth Unknown status NCT00624572 Phase 2 chlorexidine
11 Effect Of Different Lining Materials in Stepwise Excavation Unknown status NCT01730287 Phase 2 Control;Calcium Hydroxide;Mineral Trioxide Aggregate(MTA);CEM cement
12 Use of Mineral Trioxide Aggregate in the Treatment of Traumatized Teeth Completed NCT02625298 Phase 2
13 Incidence of Flare-ups and Apical Healing After Single-visit or Two-visits Treatment. Completed NCT02815189 Phase 2 Acetaminophen 325 mg for Flare up
14 Magnetic Resonance Imaging (MRI) of Pulp Regeneration Completed NCT03804450 Phase 2
15 Application of Photodynamic Therapy and Diode Laser for Endodontic Therapy of Young Permanent Teeth Completed NCT03074136 Phase 2 0.5% Sodium hypochlorite
16 Root Canal Treatment in Primary Molars With Necrotic Pulp Using Two Different Pulp Therapies Recruiting NCT03650036 Phase 2 Pulp Therapy CTZ Paste;Pulp Therapy ZOE Paste
17 A Clinical Study to Compare Two Revascularization Protocols to Treat Non-vital Teeth With Incomplete Root Formation Recruiting NCT01827098 Phase 2
18 The Use of Platelet Rich Fibrin in Pulpal and Periodontal Regeneration in Mature Teeth Withdrawn NCT02477358 Phase 1, Phase 2
19 Foraminal Enlargement and Postoperative Pain. Completed NCT02770053 Phase 1
20 Apical Patency and Postoperative Pain. Completed NCT02768285 Phase 1
21 Accuracy of ERCLMDs in Teeth With Apical Periodontitis Completed NCT01904552 Phase 1
22 Regeneration of Pulp-Dentin Development in Teeth With Necrotic Pulps and Immature Roots Active, not recruiting NCT01976065 Phase 1 Triple Antibiotic Paste
23 Revitalization of Immature Permanent Teeth With Necrotic Pulps Using SHED Cells Unknown status NCT01814436 Not Applicable
24 Comparing Between XP Endo Finisher and Conventional Irrigation Method On Post-Operative Flare Ups In Necrotic Teeth Unknown status NCT02952326 Not Applicable
25 Postoperative Pain After Endodontic Irrigation Using 1.3% Versus 5.25% Sodium Hypochlorite Completed NCT03792217 Not Applicable
26 Tissue Characterization in Teeth Treated With a Regeneration Protocol Completed NCT00881907 Early Phase 1 Triple Antibiotic Paste;Triple Antibiotic Paste;Triple Antibiotic Paste
27 Postoperative Pain and PTN and Reciproc Completed NCT03380585 Not Applicable
28 Comparison Between Reciproc and Protaper Next Completed NCT02946099 Not Applicable
29 Treatment Outcome With a Revascularization Protocol Using the Triple Versus Double Antibiotic Paste Completed NCT00881491 Early Phase 1 Double Antibiotic Paste;Triple Antibiotic Paste;Mineral Trioxide Aggregate
30 Measurement of Bite Force in Humans Completed NCT00223327
31 Reciprocation vs Rotational Single-file Systems in Postoperative Pain Completed NCT02929511 Not Applicable
32 Incidence of Post-operative Pain After Single-visit Versus Two-visit Treatment Completed NCT03120845 Not Applicable
33 Evaluation of Biodentine and Mineral Trioxide Aggregate in Revascularization of Non Vital Immature Anterior Teeth Completed NCT03589560 Not Applicable Biodentine;Mineral Trioxide Aggregate
34 Pulp Revascularization Versus MTA Apexification Completed NCT03083015 Not Applicable
35 Periapical Healing After One or Two-visits to Endodontic Treatment in Adolescents Patients Completed NCT01312194 Not Applicable
36 Effect of Root Canal Treatment (Versus no Treatment) for Patients With Tooth Infections and Toothaches Completed NCT01870973 Not Applicable
37 Antimicrobial Pastes and Clinical Cases of Apexogenesis Completed NCT03112291 Not Applicable
38 Comparative Evaluation of Different File Systems in Postoperative Pain Completed NCT03708081
39 Postoperative Pain of Root Canal Therapy With Three Techniques Completed NCT02442388 Not Applicable
40 Cytokine Regulation of Periradicular Pain in Humans Completed NCT00223470
41 Effect of Sodium Hypochlorite Concentration on Success of Non-surgical Root Canal Treatment Completed NCT03288467 Not Applicable
42 Development of a Model to Evaluate Regenerative Endodontic Techniques Using Extract Human Teeth Completed NCT00595595
43 Effect of Different Instrumentation Technique on Endodontic Outcome Completed NCT03278054 Not Applicable
44 Antimicrobial Photodynamic Therapy Associated With the Conventional Endodontic Treatment: A Clinical and Microbiological Study Completed NCT03212729 Not Applicable
45 Effect of Passive Ultrasonic Irrigation on Success of Primary Endodontic Treatment Completed NCT02632513 Not Applicable
46 Clinical and Microbiological Evaluation of 0.5% Versus 3% Sodium Hypochlorite in Root Canal Treatment Completed NCT02681276 Not Applicable
47 Direct Pulp Capping With MTA and Calcium Hydroxide. Completed NCT03284697 Not Applicable
48 Effect of Smear Layer on Endodontic Outcome Completed NCT03277404 Not Applicable
49 Evaluation of Dentinal Fluid for the Presence of Matrix Metalloproteinase 9 (MMP-9) in Pulpal Inflammation Completed NCT02967081
50 Efficacy and the Safety Study of RD94 in Patients With Endodontic Care Completed NCT01737229 Not Applicable

Search NIH Clinical Center for Dental Pulp Necrosis

Cochrane evidence based reviews: dental pulp necrosis

Genetic Tests for Dental Pulp Necrosis

Anatomical Context for Dental Pulp Necrosis

MalaCards organs/tissues related to Dental Pulp Necrosis:

41
Bone

Publications for Dental Pulp Necrosis

Articles related to Dental Pulp Necrosis:

(show all 34)
# Title Authors Year
1
Influence of Apical Diameter on the Outcome of Regenerative Endodontic Treatment in Teeth with Pulp Necrosis: A Review. ( 29273495 )
2018
2
Management of Intruded Immature Maxillary Central Incisor with Pulp Necrosis and Severe External Resorption by Regenerative Approach. ( 29275849 )
2018
3
Prevotella strains and lactamic resistance gene distribution in different oral environments of children with pulp necrosis. ( 29737548 )
2018
4
Pulp necrosis and crown discoloration: a systematic review and meta-analysis. ( 29896799 )
2018
5
There is no pulp necrosis or calcific metamorphosis of pulp induced by orthodontic treatment: biological basis. ( 30304152 )
2018
6
Cellular profile of primary molars with pulp necrosis after treatment with antibiotic paste. ( 30324690 )
2018
7
An Evidence-based Review of the Efficacy of Treatment Approaches for Immature Permanent Teeth with Pulp Necrosis. ( 28511779 )
2017
8
A prospective study of the incidence of asymptomatic pulp necrosis following crown preparation. ( 24964352 )
2015
9
Pulp necrosis of teeth retained at the mandibular fracture site and the effect of dexamethasone on its occurrence. ( 25311423 )
2015
10
Early detection of pulp necrosis and dental vitality after traumatic dental injuries in children and adolescents by 3-Tesla magnetic resonance imaging. ( 26165761 )
2015
11
Microbial profile of root canals of primary teeth with pulp necrosis and periradicular lesion. ( 24709428 )
2014
12
Microbial reduction by two chemical-mechanical protocols in primary teeth with pulp necrosis and periradicular lesion - an in vivo study. ( 25250494 )
2014
13
Predictive factors for pulp necrosis in traumatized primary incisors: a longitudinal study. ( 23331274 )
2013
14
Histologic evaluation and immunohistochemical localization of STRO-1 and BMP-4 in rat immature teeth: a comparison between vital and induced pulp necrosis. ( 23683387 )
2013
15
Combination injuries 2. The risk of pulp necrosis in permanent teeth with subluxation injuries and concomitant crown fractures. ( 22221513 )
2012
16
Combination injuries 1. The risk of pulp necrosis in permanent teeth with concussion injuries and concomitant crown fractures. ( 22221538 )
2012
17
Combination injuries 3. The risk of pulp necrosis in permanent teeth with extrusion or lateral luxation and concomitant crown fractures without pulp exposure. ( 22233180 )
2012
18
Apical periodontium response to enamel matrix derivative as an intracanal medication in rat immature teeth with pulp necrosis: radiographic and histologic findings. ( 22414828 )
2012
19
Eighteen-month clinical and radiographic evaluation of two root canal-filling materials in primary teeth with pulp necrosis secondary to trauma. ( 21342437 )
2011
20
Accidents, sports, and physical leisure activities are the most frequent causes of traumatic dental injury and the rate of pulp necrosis is high following its occurrence in Pilsen, The Czech Republic. ( 21605838 )
2011
21
Response to intracanal medication in immature teeth with pulp necrosis: an experimental model in rat molars. ( 21763896 )
2011
22
Antibacterial effects of chemomechanical instrumentation and calcium hydroxide in primary teeth with pulp necrosis. ( 21902996 )
2011
23
Pulp necrosis during septorhinoplasty. ( 20205176 )
2010
24
Arrest of root formation in a permanent maxillary central incisor subsequent to trauma and pulp necrosis to the primary predecessor. ( 18821948 )
2008
25
Dental pulp necrosis as a rare complication of reduction malarplasty. ( 17667692 )
2007
26
Er:YAG laser: antimicrobial effects in the root canals of dogs' teeth with pulp necrosis and chronic periapical lesions. ( 15954818 )
2005
27
Incidence of pulp necrosis subsequent to pulp canal obliteration from trauma of permanent incisors. ( 9198446 )
1996
28
Pulp sensibility and pulp necrosis after Le Fort I osteotomy. ( 2732335 )
1989
29
Dark-field observation of the bacterial distribution in root canals following pulp necrosis. ( 3459804 )
1986
30
Relationship between pulp dimensions and development of pulp necrosis after luxation injuries in the permanent dentition. ( 3460803 )
1986
31
Prognosis of luxated permanent teeth--the development of pulp necrosis. ( 3867505 )
1985
32
Criteria for diagnosis of pulp necrosis in traumatized permanent incisors. ( 6934614 )
1980
33
Diagnosis and treatment of pulp necrosis in permanent anterior teeth with root fracture. ( 6936763 )
1980
34
Influence of pulp necrosis and periapical inflammation of primary teeth on their permanent succesors. Combined macroscopic and histologic study in monkeys. ( 99383 )
1978

Variations for Dental Pulp Necrosis

Expression for Dental Pulp Necrosis

Search GEO for disease gene expression data for Dental Pulp Necrosis.

Pathways for Dental Pulp Necrosis

GO Terms for Dental Pulp Necrosis

Cellular components related to Dental Pulp Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.02 AMBN AMELX BMP2 DSPP LRRC7

Biological processes related to Dental Pulp Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.67 AMELX AMELY BMP2 DSPP
2 regulation of signaling receptor activity GO:0010469 9.58 AMBN AMELX BMP2
3 osteoblast differentiation GO:0001649 9.46 AMELX BMP2
4 ossification GO:0001503 9.43 BMP2 DSPP
5 cartilage development GO:0051216 9.32 BMP2 DSPP
6 chondrocyte differentiation GO:0002062 9.26 AMELX BMP2
7 epithelial to mesenchymal transition GO:0001837 9.16 AMELX BMP2
8 odontogenesis of dentin-containing tooth GO:0042475 9.13 AMBN AMELX BMP2
9 biomineral tissue development GO:0031214 8.92 AMBN AMELX AMELY DSPP

Molecular functions related to Dental Pulp Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.13 AMBN AMELX BMP2
2 structural constituent of tooth enamel GO:0030345 8.8 AMBN AMELX AMELY

Sources for Dental Pulp Necrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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