Dental Pulp Necrosis

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Dental Pulp Necrosis

MalaCards integrated aliases for Dental Pulp Necrosis:

Name: Dental Pulp Necrosis 12 44 15 73
Pulp Necrosis 12 55
Necrosis of the Pulp 12
Necrotic Pulp 12


External Ids:

Disease Ontology 12 DOID:11623
ICD10 33 K04.1
ICD9CM 35 522.1
MeSH 44 D003790
UMLS 73 C0011407

Summaries for Dental Pulp Necrosis

MalaCards based summary : Dental Pulp Necrosis, also known as pulp necrosis, is related to periapical periodontitis and dental fluorosis. An important gene associated with Dental Pulp Necrosis is DSPP (Dentin Sialophosphoprotein). The drugs Ceftibuten and Chlorhexidine have been mentioned in the context of this disorder. Affiliated tissues include bone.

Wikipedia : 76 Necrotic pulp is a finding in dentistry to describe dental pulp within a tooth which has become... more...

Related Diseases for Dental Pulp Necrosis

Graphical network of the top 20 diseases related to Dental Pulp Necrosis:

Diseases related to Dental Pulp Necrosis

Symptoms & Phenotypes for Dental Pulp Necrosis

Drugs & Therapeutics for Dental Pulp Necrosis

Drugs for Dental Pulp Necrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 86)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Ceftibuten Approved, Investigational Phase 4 97519-39-6 5282241 5282242
Chlorhexidine Approved, Vet_approved Phase 4,Not Applicable 55-56-1 9552079 2713
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
Salicylic acid Approved, Investigational, Vet_approved Phase 4 69-72-7 338
Chloramphenicol Approved, Vet_approved Phase 4 56-75-7 298 5959
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
Zinc Approved, Investigational Phase 4,Phase 1,Early Phase 1,Not Applicable 7440-66-6 23994
Zinc oxide Approved Phase 4,Not Applicable 1314-13-2
Chloramphenicol succinate Experimental Phase 4 3544-94-3
11 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
12 Bone Density Conservation Agents Phase 4,Phase 3,Phase 2,Not Applicable
13 Calcium, Dietary Phase 4,Phase 3,Phase 2,Not Applicable
14 Anesthetics Phase 4,Phase 2,Phase 1,Not Applicable
15 Antiemetics Phase 4
16 Anti-Infective Agents, Local Phase 4,Phase 1,Early Phase 1,Not Applicable
17 Anti-Inflammatory Agents Phase 4,Phase 2
18 Antineoplastic Agents, Hormonal Phase 4
19 Autonomic Agents Phase 4
20 BB 1101 Phase 4
21 Chlorhexidine gluconate Phase 4,Not Applicable
22 Dermatologic Agents Phase 4,Not Applicable
23 Dexamethasone acetate Phase 4 1177-87-3
24 Gastrointestinal Agents Phase 4
25 glucocorticoids Phase 4
26 HIV Protease Inhibitors Phase 4
27 Hormone Antagonists Phase 4
28 Hormones Phase 4
29 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
30 Peripheral Nervous System Agents Phase 4,Phase 2,Not Applicable
protease inhibitors Phase 4
32 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable
33 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable
Ciprofloxacin Approved, Investigational Phase 2, Phase 3,Phase 1,Early Phase 1 85721-33-1 2764
Metronidazole Approved Phase 2, Phase 3,Phase 1,Early Phase 1 443-48-1 4173
Cefixime Approved, Investigational Phase 2, Phase 3 79350-37-1 54362 5362065
Simvastatin Approved Phase 2, Phase 3 79902-63-9 54454
Amoxicillin Approved, Vet_approved Phase 2, Phase 3 26787-78-0 33613
39 Disinfectants Phase 2, Phase 3,Not Applicable
Acetaminophen Approved Phase 2,Not Applicable 103-90-2 1983
Epinephrine Approved, Vet_approved Phase 2,Phase 1,Not Applicable 51-43-4 5816
Ibuprofen Approved Phase 2,Not Applicable 15687-27-1 3672
Lidocaine Approved, Vet_approved Phase 2,Not Applicable 137-58-6 3676
Racepinephrine Approved Phase 2,Phase 1,Not Applicable 329-65-7 838
45 Eusol Phase 2,Phase 1,Not Applicable
46 Sodium hypochlorite Phase 2,Phase 1,Not Applicable
47 Analgesics Phase 2,Not Applicable
48 Analgesics, Non-Narcotic Phase 2
49 Anti-Inflammatory Agents, Non-Steroidal Phase 2
50 Antipyretics Phase 2

Interventional clinical trials:

(show top 50) (show all 55)
# Name Status NCT ID Phase Drugs
1 Efficiency of Triple Antibiotic Paste, Ciprofloxacin/Propolis, Ciprofloxacin/Metronidazole, Propolis/Metronidazole Combinations on Revascularization Process of Immature Necrotic Maxillary Incisors of Patients 8-18 Years Old. Completed NCT03533231 Phase 4
2 Effect of Topical Dexamethasone on Histologic Response of Human Dental Pulp Completed NCT02574468 Phase 4 Dexamethasone applied on pulp or Dexamethasone did not applied on pulp
3 Antimicrobial Pulpotomy of Primary Molars Completed NCT01010451 Phase 4
4 Comparison of Two Dental Techniques Used to Treat Teeth Which Have Become Infected or Painful Following Trauma Completed NCT01817413 Phase 4
5 Assessment of a New Apexification Method for Patients Presenting a Non Vital Immature Tooth Completed NCT00472173 Phase 3 Mineral Trioxide Aggregate;Calcium hydroxide
6 Evaluation of Postoperative Pain After Using 3MIX-TATIN Versus Calcium Hydroxide Iodoform Paste In Necrotic Primary Molars Treated by Lesion Sterilization and Tissue Repair Therapy Recruiting NCT03084601 Phase 2, Phase 3 Calcium Hydroxide, Iodoform, paste;3-mixtatin
7 Nanodiamond-Gutta Percha Composite Biomaterials for Root Canal Therapy Recruiting NCT03376984 Phase 2, Phase 3
8 Revascularization of Immature Anterior Necrotic Teeth Not yet recruiting NCT03504332 Phase 3
9 Efficacy of Chlorexidine as Intracanal Medicament in Primary Teeth Unknown status NCT00624572 Phase 2 chlorexidine
10 Effect Of Different Lining Materials in Stepwise Excavation Unknown status NCT01730287 Phase 2 Control;Calcium Hydroxide;Mineral Trioxide Aggregate(MTA);CEM cement
11 Use of Mineral Trioxide Aggregate in the Treatment of Traumatized Teeth Completed NCT02625298 Phase 2
12 Incidence of Flare-ups and Apical Healing After Single-visit or Two-visits Treatment. Completed NCT02815189 Phase 2 Acetaminophen 325 mg for Flare up
13 Application of Photodynamic Therapy and Diode Laser for Endodontic Therapy of Young Permanent Teeth Completed NCT03074136 Phase 2 0.5% Sodium hypochlorite
14 A Clinical Study to Compare Two Revascularization Protocols to Treat Non-vital Teeth With Incomplete Root Formation Recruiting NCT01827098 Phase 2
15 The Use of Platelet Rich Fibrin in Pulpal and Periodontal Regeneration in Mature Teeth Withdrawn NCT02477358 Phase 1, Phase 2
16 Foraminal Enlargement and Postoperative Pain. Completed NCT02770053 Phase 1
17 Apical Patency and Postoperative Pain. Completed NCT02768285 Phase 1
18 Accuracy of ERCLMDs in Teeth With Apical Periodontitis Completed NCT01904552 Phase 1
19 Regeneration of Pulp-Dentin Development in Teeth With Necrotic Pulps and Immature Roots Recruiting NCT01976065 Phase 1 Triple Antibiotic Paste
20 Revitalization of Immature Permanent Teeth With Necrotic Pulps Using SHED Cells Unknown status NCT01814436 Not Applicable
21 Clinical and Microbiological Evaluation of 0.5% Versus 3% Sodium Hypochlorite in Root Canal Treatment Unknown status NCT02681276 Not Applicable
22 Tissue Characterization in Teeth Treated With a Regeneration Protocol Completed NCT00881907 Early Phase 1 Triple Antibiotic Paste;Triple Antibiotic Paste;Triple Antibiotic Paste
23 Postoperative Pain and PTN and Reciproc Completed NCT03380585 Not Applicable
24 Comparison Between Reciproc and Protaper Next Completed NCT02946099 Not Applicable
25 Treatment Outcome With a Revascularization Protocol Using the Triple Versus Double Antibiotic Paste Completed NCT00881491 Early Phase 1 Double Antibiotic Paste;Triple Antibiotic Paste;Mineral Trioxide Aggregate
26 Measurement of Bite Force in Humans Completed NCT00223327
27 Reciprocation vs Rotational Single-file Systems in Postoperative Pain Completed NCT02929511 Not Applicable
28 Incidence of Post-operative Pain After Single-visit Versus Two-visit Treatment Completed NCT03120845 Not Applicable
29 Pulp Revascularization Versus MTA Apexification Completed NCT03083015 Not Applicable
30 Periapical Healing After One or Two-visits to Endodontic Treatment in Adolescents Patients Completed NCT01312194 Not Applicable
31 Effect of Root Canal Treatment (Versus no Treatment) for Patients With Tooth Infections and Toothaches Completed NCT01870973 Not Applicable
32 Antimicrobial Pastes and Clinical Cases of Apexogenesis Completed NCT03112291 Not Applicable
33 Postoperative Pain of Root Canal Therapy With Three Techniques Completed NCT02442388 Not Applicable
34 Cytokine Regulation of Periradicular Pain in Humans Completed NCT00223470
35 Effect of Sodium Hypochlorite Concentration on Success of Non-surgical Root Canal Treatment Completed NCT03288467 Not Applicable
36 Development of a Model to Evaluate Regenerative Endodontic Techniques Using Extract Human Teeth Completed NCT00595595
37 Effect of Different Instrumentation Technique on Endodontic Outcome Completed NCT03278054 Not Applicable
38 Antimicrobial Photodynamic Therapy Associated With the Conventional Endodontic Treatment: A Clinical and Microbiological Study Completed NCT03212729 Not Applicable
39 Effect of Passive Ultrasonic Irrigation on Success of Primary Endodontic Treatment Completed NCT02632513 Not Applicable
40 Direct Pulp Capping With MTA and Calcium Hydroxide. Completed NCT03284697 Not Applicable
41 Effect of Smear Layer on Endodontic Outcome Completed NCT03277404 Not Applicable
42 Evaluation of Dentinal Fluid for the Presence of Matrix Metalloproteinase 9 (MMP-9) in Pulpal Inflammation Completed NCT02967081
43 Efficacy and the Safety Study of RD94 in Patients With Endodontic Care Completed NCT01737229 Not Applicable
44 Nanodiamond Modified Gutta Percha (NDGP) Composite for Non-surgical Root Canal Therapy (RCT) Filler Material Recruiting NCT02698163 Not Applicable
45 Research of Revascularization in Immature Teeth With Periapical Periodontitis Recruiting NCT01799187 Not Applicable
46 Cone-beam Computed Tomographic (CBCT) and Regenerative Endodontic Treatment. Recruiting NCT03544528 Not Applicable
47 A Telephone-based Case-management Intervention for Caries Prevention in Children With Severe Early Childhood Caries Recruiting NCT02487043 Not Applicable
48 Apical Size and Root Canal Treatment Success Trial (AS-RCT Trial) Recruiting NCT03053037 Not Applicable
49 FE in Anterior Teeth Recruiting NCT03527602 Not Applicable
50 Comparing Between XP Endo Finisher and Conventional Irrigation Method On Post-Operative Flare Ups In Necrotic Teeth Not yet recruiting NCT02952326 Not Applicable

Search NIH Clinical Center for Dental Pulp Necrosis

Cochrane evidence based reviews: dental pulp necrosis

Genetic Tests for Dental Pulp Necrosis

Anatomical Context for Dental Pulp Necrosis

MalaCards organs/tissues related to Dental Pulp Necrosis:


Publications for Dental Pulp Necrosis

Articles related to Dental Pulp Necrosis:

# Title Authors Year
Dental pulp necrosis as a rare complication of reduction malarplasty. ( 17667692 )

Variations for Dental Pulp Necrosis

Expression for Dental Pulp Necrosis

Search GEO for disease gene expression data for Dental Pulp Necrosis.

Pathways for Dental Pulp Necrosis

GO Terms for Dental Pulp Necrosis

Biological processes related to Dental Pulp Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 odontogenesis of dentin-containing tooth GO:0042475 9.16 AMBN AMELX
2 tooth mineralization GO:0034505 8.96 AMELX AMELY
3 biomineral tissue development GO:0031214 8.92 AMBN AMELX AMELY DSPP

Molecular functions related to Dental Pulp Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of tooth enamel GO:0030345 8.8 AMBN AMELX AMELY

Sources for Dental Pulp Necrosis

9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
70 SNOMED-CT via Orphanet
72 Tocris
74 UMLS via Orphanet
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