MCID: DNT010
MIFTS: 27

Dentin Caries

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Dentin Caries

MalaCards integrated aliases for Dentin Caries:

Name: Dentin Caries 12 15
Dental Caries Extending into Dentine 12
Dental Caries Extending into Dentin 73
Compound Dental Caries 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10461
ICD9CM 35 521.02
ICD10 33 K02.1
UMLS 73 C0266846

Summaries for Dentin Caries

MalaCards based summary : Dentin Caries, also known as dental caries extending into dentine, is related to tooth erosion and aging. An important gene associated with Dentin Caries is DSPP (Dentin Sialophosphoprotein). The drugs Salicylic acid and silver nitrate have been mentioned in the context of this disorder. Affiliated tissues include bone.

Related Diseases for Dentin Caries

Diseases related to Dentin Caries via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 tooth erosion 9.9 DSPP GPI
2 aging 9.9
3 pulpitis 9.9
4 root caries 9.8 DSPP GPI
5 hypophosphatasia 9.6 ALPP DSPP
6 teeth hard tissue disease 9.5 DSPP GPI

Graphical network of the top 20 diseases related to Dentin Caries:



Diseases related to Dentin Caries

Symptoms & Phenotypes for Dentin Caries

Drugs & Therapeutics for Dentin Caries

Drugs for Dentin Caries (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Salicylic acid Approved, Investigational, Vet_approved Phase 3,Not Applicable 69-72-7 338
2 silver nitrate Approved, Investigational Phase 3
3 sodium fluoride Approved Phase 3 7681-49-4
4 Anti-Infective Agents Phase 3,Phase 1,Not Applicable
5 Pharmaceutical Solutions Phase 3,Not Applicable
6 Anti-Infective Agents, Local Phase 3,Not Applicable
7 Cariostatic Agents Phase 3,Not Applicable
8 Fluorides Phase 3,Not Applicable
9 Protective Agents Phase 3,Not Applicable
10 Listerine Phase 3
11 Calcium, Dietary Phase 1,Not Applicable
12 Anti-Bacterial Agents Phase 1,Not Applicable
13 Bone Density Conservation Agents Phase 1
14
Dopamine Approved Not Applicable 51-61-6, 62-31-7 681
15
Methamphetamine Approved, Illicit Not Applicable 537-46-2 10836
16
Miconazole Approved, Investigational, Vet_approved Not Applicable 22916-47-8 4189
17
Chlorhexidine Approved, Vet_approved Not Applicable 55-56-1 9552079 2713
18
Iodine Approved, Investigational Not Applicable 7553-56-2 807
19
Menthol Approved Not Applicable 2216-51-5 16666
20 Adrenergic Agents Not Applicable
21 Antifungal Agents Not Applicable
22 Antiviral Agents Not Applicable
23 Autonomic Agents Not Applicable
24 Carbopol 940 Not Applicable
25 Central Nervous System Stimulants Not Applicable
26 Dermatologic Agents Not Applicable
27 Dopamine Agents Not Applicable
28 Dopamine Uptake Inhibitors Not Applicable
29 Keratolytic Agents Not Applicable
30 Neurotransmitter Agents Not Applicable
31 Neurotransmitter Uptake Inhibitors Not Applicable
32 Ophthalmic Solutions Not Applicable
33 Peripheral Nervous System Agents Not Applicable
34 Anesthetics Not Applicable
35 cadexomer iodine Not Applicable
36 Chlorhexidine gluconate Not Applicable
37 Disinfectants Not Applicable
38 Micronutrients Not Applicable
39 Trace Elements Not Applicable
40 Acidophilus Nutraceutical Not Applicable

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Postoperative Hypersensitivity Randomized Comparative Effectiveness Research Trial Completed NCT01268605 Phase 3
2 The Caries-arresting Effect of Incorporating fTCP to NaF Varnish Applied Following AgNO3 in Preschool Children Recruiting NCT03423797 Phase 3 25% AgNO3 solution followed by 5% NaF;25% AgNO3 solution followed by 5% NaF with fTCP
3 Antibacterial Effect of Light-activated Calcium Silicate Versus Light-activated Calcium Hydroxide Not yet recruiting NCT03214770 Phase 1 TheraCal;light-cured calcium hydroxide
4 The Survival Rate of Glass Ionomer Cement, Glass Carbomer Cement and Compomer in Occlusal and Proximal ART Restorations Unknown status NCT02217098 Not Applicable
5 Partial Removal of Caries Dentines Unknown status NCT00887952 Not Applicable
6 Diamine Silver Fluoride and Potassium Iodide Completed NCT02771704 Not Applicable
7 Digital Subtraction Radiography Evaluation of SMART Restoration With Partial Caries Removal in Primary Teeth Completed NCT01749267 Not Applicable
8 Clinical Study of Biosilicate Under Resin Composite Restorations in Caries Affected Teeth Completed NCT02389569 Not Applicable
9 Effectiveness of Silver Diamine Fluoride in Arresting Dental Caries Recruiting NCT03063307 Not Applicable
10 Effectiveness of ART and Conventional Treatment - Practice-based Clinical Trial Recruiting NCT02568917 Not Applicable
11 Oral Health and Its Relation to Development and Well-being of Schoolchildren Before and After Restorative Treatments Recruiting NCT02754466 Not Applicable
12 Comparison of Caries Arrested & Prevented Among SDF, NaF Varnish and Combination in Children Active, not recruiting NCT03480516 Not Applicable
13 Radiographic Assessment of Glass Ionomer Restorations With and Without Prior Application of Nano Silver Fluoride in Occlusal Carious Molars Treated With Partial Caries Removal Technique Not yet recruiting NCT03193606 Not Applicable

Search NIH Clinical Center for Dentin Caries

Genetic Tests for Dentin Caries

Anatomical Context for Dentin Caries

MalaCards organs/tissues related to Dentin Caries:

41
Bone

Publications for Dentin Caries

Articles related to Dentin Caries:

(show top 50) (show all 60)
# Title Authors Year
1
Optical diagnosis of dentin caries lesions using Quantitative Light-induced Fluorescence technology. ( 29807148 )
2018
2
Caries-Preventive Effect of NaF, NaF plus TCP, NaF plus CPP-ACP, and SDF Varnishes on Sound Dentin and Artificial Dentin Caries in vitro. ( 29339648 )
2018
3
Three-dimensional diagnosis of dentin caries beneath composite restorations using swept-source optical coherence tomography. ( 29669953 )
2018
4
Fluoride activity of antibacterial ammonium hexafluorosilicate solution for the prevention of dentin caries. ( 29630795 )
2018
5
Effect of methylene blue-mediated antimicrobial photodynamic therapy on dentin caries microcosms. ( 29119417 )
2017
6
Clinical evaluation of near-infrared light transillumination in approximal dentin caries detection. ( 28653255 )
2017
7
Dentin caries risk indicators in 1-year-olds. A two year follow-up study. ( 27624864 )
2016
8
Microbiome of Deep Dentinal Caries Lesions in Teeth with Symptomatic Irreversible Pulpitis. ( 27135405 )
2016
9
Dentin caries progression and the role of metalloproteinases: an update. ( 27759416 )
2016
10
Optical analysis of enamel and dentin caries in relation to mineral density using swept-source optical coherence tomography. ( 27704033 )
2016
11
Restorative approaches to treat dentin caries in preschool children: systematic review. ( 27377109 )
2016
12
Sealing Dentin Caries with Resin-Modified Glass Ionomer Decreases Lesion Progression and Bacterial Survival in an Experimental Model. ( 25893224 )
2015
13
Non-surgical treatment of dentin caries in preschool children - systematic review. ( 25888484 )
2015
14
Effectiveness of Different Mechanical Methods on Dentin Caries Removal: Micro-CT and Digital Image Evaluation. ( 25575196 )
2015
15
Effect of Lesion Baseline Severity and Mineral Distribution on Remineralization and Progression of Human and Bovine Dentin Caries Lesions. ( 26228732 )
2015
16
Aciduric bacterial communities at three levels in dentin caries. ( 23957049 )
2013
17
Attitudes and behaviour regarding deep dentin caries removal: a survey among German dentists. ( 23899958 )
2013
18
Concomitant caries and calculus formation from in situ dentin caries model. ( 24358849 )
2013
19
Molecular and structural evaluation of dentin caries-like lesions produced by different artificial models. ( 24474358 )
2013
20
Laser fluorescence of dentin caries covered with a novel nano-filled sealant. ( 22460738 )
2013
21
Antibacterial activity of ammonium hexafluorosilicate solution with antimicrobial agents for the prevention of dentin caries. ( 22558689 )
2012
22
Dentin caries activity in early occlusal lesions selected to receive operative treatment: findings from the Practitioners Engaged in Applied Research and Learning (PEARL) Network. ( 22467698 )
2012
23
Occlusion of dentin tubules with antibacterial ammonium hexafluorosilicate solution for the prevention of dentin caries. ( 21874933 )
2011
24
Influence of Er:YAG laser frequency on dentin caries removal capacity. ( 20623778 )
2011
25
Assessment of enamel-dentin caries lesions detection using bitewing PSP digital images. ( 21986650 )
2011
26
Dentin caries zones: mineral, structure, and properties. ( 19131321 )
2009
27
Effect of adhesive restorations over incomplete dentin caries removal: 5-year follow-up study in primary teeth. ( 19619424 )
2009
28
Comparison of visual inspection and different radiographic methods for dentin caries detection on occlusal surfaces. ( 19767515 )
2009
29
Association between staining by caries detector dye and the corresponding mineral density in dentin caries. ( 19281113 )
2009
30
Use of Diagnodent for diagnosis of non-cavitated occlusal dentin caries. ( 19089284 )
2008
31
In vitro comparison of ceramic burs and conventional tungsten carbide bud burs in dentin caries excavation. ( 19057746 )
2008
32
Unrestored dentin caries and deep dentin restorations in Swedish adolescents. ( 18446024 )
2008
33
Confocal laser scanning microscopic analysis of the depth of dentin caries-like lesions in primary and permanent teeth. ( 18568229 )
2008
34
Grey levels and radiolucent lesion depth as cavity predictors for approximal dentin caries lesions in primary teeth. ( 17881594 )
2007
35
Comparison of dentin caries excavation with polymer and conventional tungsten carbide burs. ( 17694212 )
2007
36
Elastomeric impression as a diagnostic method of cavitation in proximal dentin caries in primary molars. ( 19089193 )
2007
37
Efficiency of the polymer bur SmartPrep compared with conventional tungsten carbide bud bur in dentin caries excavation. ( 16827030 )
2006
38
Evaluation of a self-limiting concept in dentinal caries removal. ( 16498079 )
2006
39
Relationship between large tubules and dentin caries in human deciduous tooth. ( 16285599 )
2005
40
Histologic evaluation of adhesive restorations on dentin caries in rat molar teeth. ( 15119678 )
2004
41
New device for selective dentin caries removal. ( 14982221 )
2003
42
Dentin caries activity status related to hardness and elasticity. ( 12786956 )
2003
43
Buonocore Memorial Lecture. Dentin caries: progression and clinical management. ( 12022450 )
2002
44
Effectiveness of silver diamine fluoride and sodium fluoride varnish in arresting dentin caries in Chinese pre-school children. ( 12407092 )
2002
45
[Effect of sodium chloride treatment on remineralization of human root dentine caries in vitro]. ( 11955357 )
2002
46
The sensitivity and specificity of clinical assessment compared with bitewing radiography for detection of occlusal dentin caries. ( 11447949 )
2001
47
[The study of histopathology and bacteriology of coronal pulp tissue in deciduous teeth with deep dentin caries]. ( 11780246 )
2000
48
Antibacterial activity of resin adhesives, glass ionomer and resin-modified glass ionomer cements and a compomer in contact with dentin caries samples. ( 11203829 )
2000
49
Molecular pathogenesis of root dentin caries. ( 10522203 )
1999
50
Oral hygiene as a risk indicator of enamel and dentin caries. ( 9792125 )
1998

Variations for Dentin Caries

Expression for Dentin Caries

Search GEO for disease gene expression data for Dentin Caries.

Pathways for Dentin Caries

GO Terms for Dentin Caries

Cellular components related to Dentin Caries according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 myelin sheath GO:0043209 8.62 GPI TCP1

Biological processes related to Dentin Caries according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 8.62 ANGPTL6 GPI

Sources for Dentin Caries

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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