MCID: DNT010
MIFTS: 26

Dentin Caries

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Dentin Caries

MalaCards integrated aliases for Dentin Caries:

Name: Dentin Caries 12 15
Dental Caries Extending into Dentine 12
Dental Caries Extending into Dentin 74
Compound Dental Caries 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10461
ICD9CM 36 521.02
SNOMED-CT 69 44828002 50047001
ICD10 34 K02 K02.1
UMLS 74 C0266846

Summaries for Dentin Caries

MalaCards based summary : Dentin Caries, also known as dental caries extending into dentine, is related to pulpitis and aging. An important gene associated with Dentin Caries is DSPP (Dentin Sialophosphoprotein). The drugs Salicylic acid and sodium fluoride have been mentioned in the context of this disorder. Affiliated tissues include bone.

Related Diseases for Dentin Caries

Diseases related to Dentin Caries via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 pulpitis 10.2
2 aging 10.0
3 isolated optic neuritis 10.0

Symptoms & Phenotypes for Dentin Caries

Drugs & Therapeutics for Dentin Caries

Drugs for Dentin Caries (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 46)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Salicylic acid Approved, Investigational, Vet_approved Phase 3,Not Applicable 69-72-7 338
2 sodium fluoride Approved Phase 3,Not Applicable 7681-49-4
3 silver nitrate Approved, Investigational Phase 3
4 Fluorides Phase 3,Not Applicable
5 Pharmaceutical Solutions Phase 3,Not Applicable
6 Protective Agents Phase 3,Not Applicable
7 Anti-Infective Agents, Local Phase 3,Not Applicable
8 Cariostatic Agents Phase 3,Not Applicable
9 Anti-Infective Agents Phase 3,Phase 1,Not Applicable
10 Listerine Phase 3,Not Applicable
11
Calcium Approved, Nutraceutical Phase 1,Not Applicable 7440-70-2 271
12 Hormones Phase 1,Not Applicable
13 Calcium, Dietary Phase 1,Not Applicable
14 Anti-Bacterial Agents Phase 1,Not Applicable
15 Bone Density Conservation Agents Phase 1
16
Chlorhexidine Approved, Vet_approved Not Applicable 55-56-1 2713 9552079
17
Iodine Approved, Investigational Not Applicable 7553-56-2 807
18
Dopamine Approved Not Applicable 62-31-7, 51-61-6 681
19
Methamphetamine Approved, Illicit Not Applicable 537-46-2 10836
20
Miconazole Approved, Investigational, Vet_approved Not Applicable 22916-47-8 4189
21
Petrolatum Approved, Investigational Not Applicable 8009-03-8
22 Anesthetics Not Applicable
23 Dermatologic Agents Not Applicable
24 Disinfectants Not Applicable
25 Micronutrients Not Applicable
26 Nutrients Not Applicable
27 cadexomer iodine Not Applicable
28 Trace Elements Not Applicable
29 Chlorhexidine gluconate Not Applicable
30 Neurotransmitter Uptake Inhibitors Not Applicable
31 Peripheral Nervous System Agents Not Applicable
32 Antiviral Agents Not Applicable
33 Dopamine Agents Not Applicable
34 Neurotransmitter Agents Not Applicable
35 Sympathomimetics Not Applicable
36 Autonomic Agents Not Applicable
37 Ophthalmic Solutions Not Applicable
38 Keratolytic Agents Not Applicable
39 Carbopol 940 Not Applicable
40 Dopamine Uptake Inhibitors Not Applicable
41 Adrenergic Agents Not Applicable
42 Antifungal Agents Not Applicable
43 Central Nervous System Stimulants Not Applicable
44 Central Nervous System Depressants Not Applicable
45 Acidophilus Not Applicable
46 Fluorides, Topical Not Applicable

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 Postoperative Hypersensitivity Randomized Comparative Effectiveness Research Trial Completed NCT01268605 Phase 3
2 The Caries-arresting Effect of Incorporating fTCP to NaF Varnish Applied Following AgNO3 in Preschool Children Active, not recruiting NCT03423797 Phase 3 25% AgNO3 solution followed by 5% NaF;25% AgNO3 solution followed by 5% NaF with fTCP
3 Effect of Low-intensity Laser and Photodynamic Therapy on Infected Dentin of Permanent Teeth With MIH Completed NCT03826810 Phase 1
4 Antibacterial Effect of Light-activated Calcium Silicate Versus Light-activated Calcium Hydroxide Not yet recruiting NCT03214770 Phase 1 TheraCal;light-cured calcium hydroxide
5 Effectiveness of ART and Conventional Treatment - Practice-based Clinical Trial Unknown status NCT02568917 Not Applicable
6 Partial Removal of Caries Dentines Unknown status NCT00887952 Not Applicable
7 Diamine Silver Fluoride and Potassium Iodide Completed NCT02771704 Not Applicable
8 Digital Subtraction Radiography Evaluation of SMART Restoration With Partial Caries Removal in Primary Teeth Completed NCT01749267 Not Applicable
9 The Survival Rate of Glass Ionomer Cement, Glass Carbomer Cement and Compomer in Occlusal and Proximal ART Restorations Completed NCT02217098 Not Applicable
10 Clinical Study of Biosilicate Under Resin Composite Restorations in Caries Affected Teeth Completed NCT02389569 Not Applicable
11 Effectiveness of Silver Diamine Fluoride in Arresting Dental Caries Recruiting NCT03063307 Not Applicable
12 Isolation of the Operative Field Influences the Survival Rate of Composite Restorations Recruiting NCT03733522 Not Applicable
13 Laser Used in the Treatment of Hypomineralized Occlusal Lesions in Teeth Enamel Affected by MIH Recruiting NCT03614819 Not Applicable
14 Effects of Partical Excavation in One Versus Two Procedures of Primary Deep Caries (PAPRICA) Recruiting NCT03696498 Not Applicable
15 Outcomes of Restoring Untreated and SDF-treated Dentine Caries Lesions in Primary Teeth of Preschool Children Active, not recruiting NCT03657862 Not Applicable
16 Radiographic Assessment of Glass Ionomer Restorations With and Without Prior Application of Nano Silver Fluoride in Occlusal Carious Molars Treated With Partial Caries Removal Technique Active, not recruiting NCT03193606 Not Applicable
17 Comparison of Conventional Versus Conservative Caries Removal in Primary Teeth Active, not recruiting NCT03650647 Not Applicable
18 Oral Health and Its Relation to Development and Well-being of Schoolchildren Before and After Restorative Treatments Active, not recruiting NCT02754466 Not Applicable
19 Comparison of Caries Arrested & Prevented Among SDF, NaF Varnish and Combination in Children Active, not recruiting NCT03480516 Not Applicable

Search NIH Clinical Center for Dentin Caries

Genetic Tests for Dentin Caries

Anatomical Context for Dentin Caries

MalaCards organs/tissues related to Dentin Caries:

42
Bone

Publications for Dentin Caries

Articles related to Dentin Caries:

(show top 50) (show all 67)
# Title Authors Year
1
Long-term survival of different deep dentin caries treatments: A 5-year clinical study. ( 30666030 )
2019
2
Microcomputed Tomography Evaluation of Root Dentin Caries Prevention by Topical Fluorides and Potassium Iodide. ( 30791530 )
2019
3
Can red fluorescence be useful in diagnostic decision making of residual dentin caries? ( 30797117 )
2019
4
Remineralization effects of conventional and experimental ion-releasing materials in chemically or bacterially-induced dentin caries lesions. ( 30853209 )
2019
5
Optical diagnosis of dentin caries lesions using Quantitative Light-induced Fluorescence technology. ( 29807148 )
2018
6
Caries-Preventive Effect of NaF, NaF plus TCP, NaF plus CPP-ACP, and SDF Varnishes on Sound Dentin and Artificial Dentin Caries in vitro. ( 29339648 )
2018
7
Three-dimensional diagnosis of dentin caries beneath composite restorations using swept-source optical coherence tomography. ( 29669953 )
2018
8
Fluoride activity of antibacterial ammonium hexafluorosilicate solution for the prevention of dentin caries. ( 29630795 )
2018
9
Functional profiles of coronal and dentin caries in children. ( 30034639 )
2018
10
Comparison of initial oral microbiomes of young adults with and without cavitated dentin caries lesions using an in situ biofilm model. ( 30228377 )
2018
11
Curcumin-mediated antimicrobial photodynamic therapy reduces the viability and vitality of infected dentin caries microcosms. ( 30240927 )
2018
12
Scientific evidence for the management of dentin caries lesions in pediatric dentistry: A systematic review and network meta-analysis. ( 30462676 )
2018
13
Profile of high-fluoride toothpastes combined or not with functionalized tri-calcium phosphate on root dentin caries control: An in vitro study. ( 30658374 )
2018
14
Effect of methylene blue-mediated antimicrobial photodynamic therapy on dentin caries microcosms. ( 29119417 )
2017
15
Clinical evaluation of near-infrared light transillumination in approximal dentin caries detection. ( 28653255 )
2017
16
Dentin caries risk indicators in 1-year-olds. A two year follow-up study. ( 27624864 )
2016
17
Dentin caries progression and the role of metalloproteinases: an update. ( 27759416 )
2016
18
Optical analysis of enamel and dentin caries in relation to mineral density using swept-source optical coherence tomography. ( 27704033 )
2016
19
Restorative approaches to treat dentin caries in preschool children: systematic review. ( 27377109 )
2016
20
Sealing Dentin Caries with Resin-Modified Glass Ionomer Decreases Lesion Progression and Bacterial Survival in an Experimental Model. ( 25893224 )
2015
21
Non-surgical treatment of dentin caries in preschool children - systematic review. ( 25888484 )
2015
22
Effectiveness of Different Mechanical Methods on Dentin Caries Removal: Micro-CT and Digital Image Evaluation. ( 25575196 )
2015
23
Effect of Lesion Baseline Severity and Mineral Distribution on Remineralization and Progression of Human and Bovine Dentin Caries Lesions. ( 26228732 )
2015
24
Aciduric bacterial communities at three levels in dentin caries. ( 23957049 )
2013
25
Attitudes and behaviour regarding deep dentin caries removal: a survey among German dentists. ( 23899958 )
2013
26
Concomitant caries and calculus formation from in situ dentin caries model. ( 24358849 )
2013
27
Molecular and structural evaluation of dentin caries-like lesions produced by different artificial models. ( 24474358 )
2013
28
Laser fluorescence of dentin caries covered with a novel nano-filled sealant. ( 22460738 )
2013
29
Antibacterial activity of ammonium hexafluorosilicate solution with antimicrobial agents for the prevention of dentin caries. ( 22558689 )
2012
30
Dentin caries activity in early occlusal lesions selected to receive operative treatment: findings from the Practitioners Engaged in Applied Research and Learning (PEARL) Network. ( 22467698 )
2012
31
Occlusion of dentin tubules with antibacterial ammonium hexafluorosilicate solution for the prevention of dentin caries. ( 21874933 )
2011
32
Influence of Er:YAG laser frequency on dentin caries removal capacity. ( 20623778 )
2011
33
Assessment of enamel-dentin caries lesions detection using bitewing PSP digital images. ( 21986650 )
2011
34
Dentin caries zones: mineral, structure, and properties. ( 19131321 )
2009
35
Effect of adhesive restorations over incomplete dentin caries removal: 5-year follow-up study in primary teeth. ( 19619424 )
2009
36
Comparison of visual inspection and different radiographic methods for dentin caries detection on occlusal surfaces. ( 19767515 )
2009
37
Association between staining by caries detector dye and the corresponding mineral density in dentin caries. ( 19281113 )
2009
38
Use of Diagnodent for diagnosis of non-cavitated occlusal dentin caries. ( 19089284 )
2008
39
In vitro comparison of ceramic burs and conventional tungsten carbide bud burs in dentin caries excavation. ( 19057746 )
2008
40
Unrestored dentin caries and deep dentin restorations in Swedish adolescents. ( 18446024 )
2008
41
Confocal laser scanning microscopic analysis of the depth of dentin caries-like lesions in primary and permanent teeth. ( 18568229 )
2008
42
Grey levels and radiolucent lesion depth as cavity predictors for approximal dentin caries lesions in primary teeth. ( 17881594 )
2007
43
Comparison of dentin caries excavation with polymer and conventional tungsten carbide burs. ( 17694212 )
2007
44
Elastomeric impression as a diagnostic method of cavitation in proximal dentin caries in primary molars. ( 19089193 )
2007
45
Efficiency of the polymer bur SmartPrep compared with conventional tungsten carbide bud bur in dentin caries excavation. ( 16827030 )
2006
46
Relationship between large tubules and dentin caries in human deciduous tooth. ( 16285599 )
2005
47
Histologic evaluation of adhesive restorations on dentin caries in rat molar teeth. ( 15119678 )
2004
48
New device for selective dentin caries removal. ( 14982221 )
2003
49
Dentin caries activity status related to hardness and elasticity. ( 12786956 )
2003
50
Buonocore Memorial Lecture. Dentin caries: progression and clinical management. ( 12022450 )
2002

Variations for Dentin Caries

Expression for Dentin Caries

Search GEO for disease gene expression data for Dentin Caries.

Pathways for Dentin Caries

GO Terms for Dentin Caries

Cellular components related to Dentin Caries according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 myelin sheath GO:0043209 8.62 IMMT TCP1

Sources for Dentin Caries

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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