MCID: DNT010
MIFTS: 32

Dentin Caries

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Dentin Caries

MalaCards integrated aliases for Dentin Caries:

Name: Dentin Caries 12 15
Dental Caries Extending into Dentine 12
Dental Caries Extending into Dentin 70
Compound Dental Caries 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10461
ICD9CM 34 521.02
SNOMED-CT 67 442551007
ICD10 32 K02 K02.1
UMLS 70 C0266846

Summaries for Dentin Caries

MalaCards based summary : Dentin Caries, also known as dental caries extending into dentine, is related to dental caries and root caries. An important gene associated with Dentin Caries is DSPP (Dentin Sialophosphoprotein), and among its related pathways/superpathways are Degradation of the extracellular matrix and NAD metabolism. The drugs Hormones and Calcium, Dietary have been mentioned in the context of this disorder. Affiliated tissues include testis, tongue and bone.

Related Diseases for Dentin Caries

Graphical network of the top 20 diseases related to Dentin Caries:



Diseases related to Dentin Caries

Symptoms & Phenotypes for Dentin Caries

Drugs & Therapeutics for Dentin Caries

Drugs for Dentin Caries (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hormones Phase 1
2 Calcium, Dietary Phase 1
3
Calcium Nutraceutical Phase 1 7440-70-2 271
4
Silicon Approved, Investigational 7440-21-3 4082203
5
Pemetrexed Approved, Investigational 150399-23-8, 137281-23-3 446556 60843
6
Levoleucovorin Approved, Investigational 68538-85-2 149436
7
Salicylic acid Approved, Investigational, Vet_approved 69-72-7 338
8
Chlorhexidine Approved, Vet_approved 55-56-1 9552079 2713
9
Iodine Approved, Investigational 7553-56-2 807
10
Petrolatum Approved, Investigational 8009-03-8
11
Folic acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
12
Cadexomer iodine Experimental 94820-09-4
13 Anti-Bacterial Agents
14 Folic Acid Antagonists
15 Vitamin B9
16 Folate
17 Vitamin B Complex
18 Pharmaceutical Solutions
19 Protective Agents
20 Fluorides
21 Propolis
22 Anti-Infective Agents
23 Bee Products
24 Acidophilus
25 Trace Elements
26 Anti-Infective Agents, Local
27 Nutrients
28 Micronutrients
29 Chlorhexidine gluconate
30 Disinfectants
31 Anesthetics
32 Anesthetics, Local
33 Carbopol 940

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Antibacterial Effect of Light-activated Calcium Silicate Versus Calcium Hydroxide on Permanent Carious Molars Treated With Step-wise Excavation (A Randomized Clinical Trial) Unknown status NCT03214770 Phase 1 TheraCal;light-cured calcium hydroxide
2 Randomized Clinical Trial Comparison of Conventional Versus Conservative Caries Removal in Primary Teeth: a Two-year Evaluation Unknown status NCT03650647
3 Comparative Study on the Outcomes of Restoring Untreated and SDF-treated Dentine Caries Lesions in Primary Teeth of Preschool Children Unknown status NCT03657862
4 Clinical and Digital Subtraction Radiography Evaluation of Partial Caries Removal in Primary Teeth Completed NCT01749267
5 Randomized, Controlled Clinical Evaluation of Extensive Direct Composite Restorations With Polyethylene Fiber in the First Permanent Molars of Children Completed NCT04612543
6 Evaluation of the Efficacy of Er,Cr:YSGG Laser in Partial Pulpotomy Therapy of Permanent Immature Molar Teeth With Deep Dentin Caries Completed NCT04010929
7 Effectiveness of an ICCMS™ Caries Management Program. A Schoolchildren Multicenter Randomized Controlled Trial. Completed NCT04676230
8 Management of Occlusal Dentinal Caries in Deciduous Molars- A Clinical and Radiographic Evaluation of Three Approaches Completed NCT03552835
9 Investigation of Atraumatic Restorative Treatment by in Vivo and in Vitro Methods in Terms of the Microbiological, Marginal Adaptation and Microleakage Completed NCT04813744
10 Evaluation of the Remineralizing and Antibacterial Effect of Natural Versus Synthetic Materials on Deep Carious Dentin Completed NCT04145102
11 Radiographic Assessment of Glass Ionomer Restorations With and Without Prior Application of Nano Silver Fluoride in Occlusal Carious Molars Treated With Partial Caries Removal Technique (Randomized Clinical Trial) Completed NCT03193606
12 In Vivo Evaluation of the Antimicrobial Activity of Diamine Silver Fluoride and Potassium Iodide on Dentin Carious Lesions in Kuwaiti Subjects. Completed NCT02771704
13 Excavation of Root Caries With Air-water Powder Stream vs Manual Excavation for Atraumatic Restorative Treatment in Older Patients: a Single-blind Randomized Controlled Trial Not yet recruiting NCT04822246
14 Oral Health and Its Relation to Growth, Development and Well-being of Schoolchildren Before and After Restorative Treatments Suspended NCT02754466

Search NIH Clinical Center for Dentin Caries

Genetic Tests for Dentin Caries

Anatomical Context for Dentin Caries

MalaCards organs/tissues related to Dentin Caries:

40
Testis, Tongue, Bone

Publications for Dentin Caries

Articles related to Dentin Caries:

(show top 50) (show all 343)
# Title Authors PMID Year
1
In vitro comparison of two types of digital X-ray sensors for proximal caries detection validated by micro-computed tomography. 61
32822231 2021
2
Comparison of novel and established caries diagnostic methods: a clinical study on occlusal surfaces. 61
33663454 2021
3
Effect of ionizing radiation and cariogenic biofilm challenge on root-dentin caries. 61
33765193 2021
4
Protective effect of titanium tetrafluoride and silver diamine fluoride on radiation-induced dentin caries in vitro. 61
33727650 2021
5
Antimicrobial effects of silver diamine fluoride: An in vivo study. 61
33544989 2021
6
Coherent surface structure induces unique epitaxial overgrowth of metastable octacalcium phosphate on stable hydroxyapatite at critical fluoride concentration. 61
33631397 2021
7
Use of phosphorylated PAMAM and carboxyled PAMAM to induce dentin biomimetic remineralization and dentinal tubule occlusion. 61
33642446 2021
8
Assessment of dental pain in children with intellectual disability using the dental discomfort questionnaire. 61
33499707 2021
9
Inhibitory effect of Salvadora persica extract (Miswak) on collagen degradation in demineralized dentin: In vitro study. 61
33384799 2021
10
Demineralization Inhibitory Effects of Highly Concentrated Fluoride Dentifrice and Fluoride Gels/Solutions on Sound Dentin and Artificial Dentin Caries Lesions in vitro. 61
33285548 2021
11
Near-infrared transillumination with high dynamic range imaging for occlusal caries detection in vitro. 61
32594346 2020
12
The efficacy of dental sealant used with bonding agent on occlusal caries (ICDAS 2-4): A 24-month randomized clinical trial. 61
33220141 2020
13
Is it worth using low-cost glass ionomer cements for occlusal ART restorations in primary molars? 2-year survival and cost analysis of a Randomized clinical trial. 61
32758684 2020
14
Laser induced fluorescence with 2-D Hilbert transform edge detection algorithm and 3D fluorescence images for white spot early recognition. 61
32604049 2020
15
Influence of Silver Diamine Fluoride Treatment on the Microtensile Bond Strength of Glass Ionomer Cement to Sound and Carious Dentin. 61
32502257 2020
16
3D imaging of proximal caries in posterior teeth using optical coherence tomography. 61
32978464 2020
17
EMILIN proteins are novel extracellular constituents of the dentin-pulp complex. 61
32948785 2020
18
Clinical performance of clinical-visual examination, digital bitewing radiography, laser fluorescence, and near-infrared light transillumination for detection of non-cavitated proximal enamel and dentin caries. 61
32333336 2020
19
A randomized clinical trial to arrest dentin caries in young children using silver diamine fluoride. 61
32428523 2020
20
Human closed and open apex premolar teeth express different toll-like receptor. 61
32400961 2020
21
Temporomandibular dysfunction assessment in children treated with the Hall Technique: A pilot study. 61
31991506 2020
22
Structural and Functional Characteristics of the Microbiome in Deep-Dentin Caries. 61
32196394 2020
23
Comparison between conventional and chemomechanical approaches for the removal of carious dentin: an in vitro study. 61
32415190 2020
24
Effect of silver diamine fluoride on the bond durability of normal and carious dentin. 61
32509229 2020
25
In vivo performance of near-infrared light transillumination for dentine proximal caries detection in permanent teeth. 61
32405221 2020
26
The effects of photodynamic therapy with blue light and papain-based gel associated with Urucum, on collagen and fibroblasts: a spectroscopic and cytotoxicity analysis. 61
31407100 2020
27
Diagnosis of Occlusal Caries with Dynamic Slicing of 3D Optical Coherence Tomography Images. 61
32192069 2020
28
Dentin degradonomics - The potential role of salivary MMP-8 in dentin caries. 61
32071691 2020
29
Effects of Dentifrices Differing in Fluoride Content on Remineralization Characteristics of Dentin in vitro. 61
31775152 2020
30
Is Fluorescence Technology a Promising Tool for Detecting Infected Dentin in Deep Carious Lesions? 61
32580204 2020
31
Follow-up interval for dental appointments: a randomized clinical trial with children with low caries risk. 61
33331406 2020
32
Disinfection of Cariogenic Pathogens in Planktonic Lifestyle, Biofilm and Carious Dentine with Antimicrobial Photodynamic Therapy. 61
31483869 2020
33
How to Intervene in the Caries Process: Dentin Caries in Primary Teeth. 61
32854105 2020
34
The frequency of enamel and dentin caries lesions among elderly Norwegians. 61
31267814 2020
35
[Spectroscopic studies of the molecular composition of the dentinal and gingival fluids and their diagnostic potential for preventive screening of dentin caries]. 61
33034171 2020
36
In vitro comparison of two photostimulable phosphor plate systems for early detection of occlusal dentin caries with and without a sharpening filter. 61
33575011 2020
37
The use of photodynamic therapy in the treatment of dental caries in children of contaminated areas of the ecosystem of the upper tysa region. 61
32285818 2020
38
Enamel and Dentin Caries Risk Factors of Adolescents in the Context of the International Caries Detection and Assessment System (ICDAS): A Longitudinal Study. 61
32850535 2020
39
Accurate Detection of Non-Cavitated Proximal Caries in Posterior Permanent Teeth: An in vivo Study. 61
32943960 2020
40
Does low-cost GIC have the same survival rate as high-viscosity GIC in atraumatic restorative treatments? A RCT. 61
31994598 2020
41
Nanosilver Fluoride-A Paradigm Shift for Arrest in Dental Caries in Primary Teeth of Schoolchildren: A Randomized Controlled Clinical Trial. 61
32440060 2019
42
Remineralization of Natural Human Carious Dentin Lesions with an Experimental Whisker-Reinforced Atraumatic Restorative Treatment Composite. 61
29323776 2019
43
The effectiveness of curcumin-mediated antimicrobial photodynamic therapy depends on pre-irradiation and biofilm growth times. 61
31310825 2019
44
Bonding Performance of Universal Adhesive Systems Applied in Etch-and-Rinse and Self-Etch Strategies on Natural Dentin Caries. 61
31461392 2019
45
Could a chelant improve the effect of curcumin-mediated photodynamic antimicrobial chemotherapy against dental intact biofilms? 61
30604346 2019
46
Dental caries lesions in primary teeth without obvious cavitation: Treatment decision-making process. 61
30803096 2019
47
Remineralization of Artificial Dentin Caries Using Dentin and Enamel Matrix Proteins. 61
31266157 2019
48
Histological determination of cariously altered collagen after dentin caries excavation with the polymer bur PolyBur P1 in comparison to a conventional bud bur. 61
31307514 2019
49
Scientific evidence in antimicrobial photodynamic therapy: An alternative approach for reducing cariogenic bacteria. 61
30898559 2019
50
Can red fluorescence be useful in diagnostic decision making of residual dentin caries? 61
30797117 2019

Variations for Dentin Caries

Expression for Dentin Caries

Search GEO for disease gene expression data for Dentin Caries.

Pathways for Dentin Caries

Pathways related to Dentin Caries according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.21 MMP8 MMP20 MMP2 DSPP
2
Show member pathways
11.8 ALPP ALPI ALPG
3
Show member pathways
11.72 ALPP ALPI ALPG
4
Show member pathways
11.33 MMP8 MMP20 MMP2
5
Show member pathways
10.59 ALPP ALPI ALPG
6 10 ALPP ALPI ALPG

GO Terms for Dentin Caries

Cellular components related to Dentin Caries according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 MMP8 MMP20 MMP2 MEPE IGLL1 DSPP
2 anchored component of membrane GO:0031225 9.33 ALPP ALPI ALPG
3 extracellular matrix GO:0031012 9.02 MMP8 MMP20 MMP2 MEPE DSPP

Biological processes related to Dentin Caries according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.71 SENP7 MMP8 MMP20 MMP2
2 extracellular matrix organization GO:0030198 9.46 MMP8 MMP20 MMP2 DSPP
3 dephosphorylation GO:0016311 9.43 ALPP ALPI ALPG
4 biomineral tissue development GO:0031214 9.37 MEPE DSPP
5 endodermal cell differentiation GO:0035987 9.32 MMP8 MMP2
6 extracellular matrix disassembly GO:0022617 9.13 MMP8 MMP20 MMP2
7 collagen catabolic process GO:0030574 8.8 MMP8 MMP20 MMP2

Molecular functions related to Dentin Caries according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.71 SENP7 MMP8 MMP20 MMP2
2 zinc ion binding GO:0008270 9.65 MMP8 MMP20 MMP2 ALPP ALPI
3 metallopeptidase activity GO:0008237 9.54 MMP8 MMP20 MMP2
4 phosphatase activity GO:0016791 9.5 ALPP ALPI ALPG
5 hydrolase activity GO:0016787 9.5 SENP7 MMP8 MMP20 MMP2 ALPP ALPI
6 metalloendopeptidase activity GO:0004222 9.33 MMP8 MMP20 MMP2
7 alkaline phosphatase activity GO:0004035 8.8 ALPP ALPI ALPG

Sources for Dentin Caries

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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