MCID: DNT010
MIFTS: 26

Dentin Caries

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Dentin Caries

MalaCards integrated aliases for Dentin Caries:

Name: Dentin Caries 12 15
Dental Caries Extending into Dentine 12
Dental Caries Extending into Dentin 73
Compound Dental Caries 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10461
ICD10 33 K02 K02.1
ICD9CM 35 521.02
SNOMED-CT 68 44828002 50047001
UMLS 73 C0266846

Summaries for Dentin Caries

MalaCards based summary : Dentin Caries, also known as dental caries extending into dentine, is related to aging and pulpitis. An important gene associated with Dentin Caries is DSPP (Dentin Sialophosphoprotein). The drugs Salicylic acid and sodium fluoride have been mentioned in the context of this disorder.

Related Diseases for Dentin Caries

Diseases related to Dentin Caries via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 aging 10.0
2 pulpitis 10.0
3 hypophosphatasia 9.8 ALPP DSPP

Symptoms & Phenotypes for Dentin Caries

Drugs & Therapeutics for Dentin Caries

Drugs for Dentin Caries (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Salicylic acid Approved, Investigational, Vet_approved Phase 3,Not Applicable 69-72-7 338
2 sodium fluoride Approved Phase 3,Not Applicable 7681-49-4
3 silver nitrate Approved, Investigational Phase 3
4 Cariostatic Agents Phase 3,Not Applicable
5 Protective Agents Phase 3,Not Applicable
6 Fluorides Phase 3,Not Applicable
7 Anti-Infective Agents Phase 3,Phase 1,Not Applicable
8 Anti-Infective Agents, Local Phase 3,Not Applicable
9 Pharmaceutical Solutions Phase 3,Not Applicable
10 Listerine Phase 3,Not Applicable
11 Calcium, Dietary Phase 1,Not Applicable
12 Anti-Bacterial Agents Phase 1,Not Applicable
13 Bone Density Conservation Agents Phase 1
14
Chlorhexidine Approved, Vet_approved Not Applicable 55-56-1 2713 9552079
15
Iodine Approved, Investigational Not Applicable 7553-56-2 807
16
Dopamine Approved Not Applicable 51-61-6, 62-31-7 681
17
Methamphetamine Approved, Illicit Not Applicable 537-46-2 10836
18
Miconazole Approved, Investigational, Vet_approved Not Applicable 22916-47-8 4189
19
Petrolatum Approved, Investigational Not Applicable 8009-03-8
20 Anesthetics Not Applicable
21 Micronutrients Not Applicable
22 Dermatologic Agents Not Applicable
23 Chlorhexidine gluconate Not Applicable
24 cadexomer iodine Not Applicable
25 Trace Elements Not Applicable
26 Disinfectants Not Applicable
27 Ophthalmic Solutions Not Applicable
28 Neurotransmitter Uptake Inhibitors Not Applicable
29 Keratolytic Agents Not Applicable
30 Antiviral Agents Not Applicable
31 Sympathomimetics Not Applicable
32 Antifungal Agents Not Applicable
33 Adrenergic Agents Not Applicable
34 Dopamine Uptake Inhibitors Not Applicable
35 Carbopol 940 Not Applicable
36 Dopamine Agents Not Applicable
37 Neurotransmitter Agents Not Applicable
38 Central Nervous System Stimulants Not Applicable
39 Autonomic Agents Not Applicable
40 Peripheral Nervous System Agents Not Applicable
41 Fluorides, Topical Not Applicable
42 Acidophilus Not Applicable

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 Postoperative Hypersensitivity Randomized Comparative Effectiveness Research Trial Completed NCT01268605 Phase 3
2 The Caries-arresting Effect of Incorporating fTCP to NaF Varnish Applied Following AgNO3 in Preschool Children Active, not recruiting NCT03423797 Phase 3 25% AgNO3 solution followed by 5% NaF;25% AgNO3 solution followed by 5% NaF with fTCP
3 Antibacterial Effect of Light-activated Calcium Silicate Versus Light-activated Calcium Hydroxide Not yet recruiting NCT03214770 Phase 1 TheraCal;light-cured calcium hydroxide
4 Effectiveness of ART and Conventional Treatment - Practice-based Clinical Trial Unknown status NCT02568917 Not Applicable
5 Partial Removal of Caries Dentines Unknown status NCT00887952 Not Applicable
6 Diamine Silver Fluoride and Potassium Iodide Completed NCT02771704 Not Applicable
7 Digital Subtraction Radiography Evaluation of SMART Restoration With Partial Caries Removal in Primary Teeth Completed NCT01749267 Not Applicable
8 The Survival Rate of Glass Ionomer Cement, Glass Carbomer Cement and Compomer in Occlusal and Proximal ART Restorations Completed NCT02217098 Not Applicable
9 Clinical Study of Biosilicate Under Resin Composite Restorations in Caries Affected Teeth Completed NCT02389569 Not Applicable
10 Effectiveness of Silver Diamine Fluoride in Arresting Dental Caries Recruiting NCT03063307 Not Applicable
11 Laser Used in the Treatment of Hypomineralized Occlusal Lesions in Teeth Enamel Affected by MIH Recruiting NCT03614819 Not Applicable
12 Effects of Partical Excavation in One Versus Two Procedures of Primary Deep Caries (PAPRICA) Recruiting NCT03696498 Not Applicable
13 Outcomes of Restoring Untreated and SDF-treated Dentine Caries Lesions in Primary Teeth of Preschool Children Active, not recruiting NCT03657862 Not Applicable
14 Comparison of Conventional Versus Conservative Caries Removal in Primary Teeth Active, not recruiting NCT03650647 Not Applicable
15 Oral Health and Its Relation to Development and Well-being of Schoolchildren Before and After Restorative Treatments Active, not recruiting NCT02754466 Not Applicable
16 Comparison of Caries Arrested & Prevented Among SDF, NaF Varnish and Combination in Children Active, not recruiting NCT03480516 Not Applicable
17 Radiographic Assessment of Glass Ionomer Restorations With and Without Prior Application of Nano Silver Fluoride in Occlusal Carious Molars Treated With Partial Caries Removal Technique Enrolling by invitation NCT03193606 Not Applicable
18 Isolation of the Operative Field Influences the Survival Rate of Composite Restorations Not yet recruiting NCT03733522 Not Applicable

Search NIH Clinical Center for Dentin Caries

Genetic Tests for Dentin Caries

Anatomical Context for Dentin Caries

Publications for Dentin Caries

Articles related to Dentin Caries:

(show top 50) (show all 62)
# Title Authors Year
1
Caries-Preventive Effect of NaF, NaF plus TCP, NaF plus CPP-ACP, and SDF Varnishes on Sound Dentin and Artificial Dentin Caries in vitro. ( 29339648 )
2018
2
Three-dimensional diagnosis of dentin caries beneath composite restorations using swept-source optical coherence tomography. ( 29669953 )
2018
3
Fluoride activity of antibacterial ammonium hexafluorosilicate solution for the prevention of dentin caries. ( 29630795 )
2018
4
Scientific evidence for the management of dentin caries lesions in pediatric dentistry: A systematic review and network meta-analysis. ( 30462676 )
2018
5
Curcumin-mediated antimicrobial photodynamic therapy reduces the viability and vitality of infected dentin caries microcosms. ( 30240927 )
2018
6
Comparison of initial oral microbiomes of young adults with and without cavitated dentin caries lesions using an in situ biofilm model. ( 30228377 )
2018
7
Functional profiles of coronal and dentin caries in children. ( 30034639 )
2018
8
Optical diagnosis of dentin caries lesions using Quantitative Light-induced Fluorescence technology. ( 29807148 )
2018
9
Effect of methylene blue-mediated antimicrobial photodynamic therapy on dentin caries microcosms. ( 29119417 )
2017
10
Clinical evaluation of near-infrared light transillumination in approximal dentin caries detection. ( 28653255 )
2017
11
Dentin caries risk indicators in 1-year-olds. A two year follow-up study. ( 27624864 )
2016
12
Dentin caries progression and the role of metalloproteinases: an update. ( 27759416 )
2016
13
Optical analysis of enamel and dentin caries in relation to mineral density using swept-source optical coherence tomography. ( 27704033 )
2016
14
Restorative approaches to treat dentin caries in preschool children: systematic review. ( 27377109 )
2016
15
Effectiveness of Different Mechanical Methods on Dentin Caries Removal: Micro-CT and Digital Image Evaluation. ( 25575196 )
2015
16
Effect of Lesion Baseline Severity and Mineral Distribution on Remineralization and Progression of Human and Bovine Dentin Caries Lesions. ( 26228732 )
2015
17
Non-surgical treatment of dentin caries in preschool children - systematic review. ( 25888484 )
2015
18
Sealing Dentin Caries with Resin-Modified Glass Ionomer Decreases Lesion Progression and Bacterial Survival in an Experimental Model. ( 25893224 )
2015
19
Aciduric bacterial communities at three levels in dentin caries. ( 23957049 )
2013
20
Concomitant caries and calculus formation from in situ dentin caries model. ( 24358849 )
2013
21
Molecular and structural evaluation of dentin caries-like lesions produced by different artificial models. ( 24474358 )
2013
22
Laser fluorescence of dentin caries covered with a novel nano-filled sealant. ( 22460738 )
2013
23
Attitudes and behaviour regarding deep dentin caries removal: a survey among German dentists. ( 23899958 )
2013
24
Antibacterial activity of ammonium hexafluorosilicate solution with antimicrobial agents for the prevention of dentin caries. ( 22558689 )
2012
25
Dentin caries activity in early occlusal lesions selected to receive operative treatment: findings from the Practitioners Engaged in Applied Research and Learning (PEARL) Network. ( 22467698 )
2012
26
Occlusion of dentin tubules with antibacterial ammonium hexafluorosilicate solution for the prevention of dentin caries. ( 21874933 )
2011
27
Influence of Er:YAG laser frequency on dentin caries removal capacity. ( 20623778 )
2011
28
Assessment of enamel-dentin caries lesions detection using bitewing PSP digital images. ( 21986650 )
2011
29
Dentin caries zones: mineral, structure, and properties. ( 19131321 )
2009
30
Effect of adhesive restorations over incomplete dentin caries removal: 5-year follow-up study in primary teeth. ( 19619424 )
2009
31
Comparison of visual inspection and different radiographic methods for dentin caries detection on occlusal surfaces. ( 19767515 )
2009
32
Association between staining by caries detector dye and the corresponding mineral density in dentin caries. ( 19281113 )
2009
33
Use of Diagnodent for diagnosis of non-cavitated occlusal dentin caries. ( 19089284 )
2008
34
Unrestored dentin caries and deep dentin restorations in Swedish adolescents. ( 18446024 )
2008
35
Confocal laser scanning microscopic analysis of the depth of dentin caries-like lesions in primary and permanent teeth. ( 18568229 )
2008
36
In vitro comparison of ceramic burs and conventional tungsten carbide bud burs in dentin caries excavation. ( 19057746 )
2008
37
Grey levels and radiolucent lesion depth as cavity predictors for approximal dentin caries lesions in primary teeth. ( 17881594 )
2007
38
Comparison of dentin caries excavation with polymer and conventional tungsten carbide burs. ( 17694212 )
2007
39
Elastomeric impression as a diagnostic method of cavitation in proximal dentin caries in primary molars. ( 19089193 )
2007
40
Efficiency of the polymer bur SmartPrep compared with conventional tungsten carbide bud bur in dentin caries excavation. ( 16827030 )
2006
41
Relationship between large tubules and dentin caries in human deciduous tooth. ( 16285599 )
2005
42
Histologic evaluation of adhesive restorations on dentin caries in rat molar teeth. ( 15119678 )
2004
43
New device for selective dentin caries removal. ( 14982221 )
2003
44
Dentin caries activity status related to hardness and elasticity. ( 12786956 )
2003
45
Buonocore Memorial Lecture. Dentin caries: progression and clinical management. ( 12022450 )
2002
46
Effectiveness of silver diamine fluoride and sodium fluoride varnish in arresting dentin caries in Chinese pre-school children. ( 12407092 )
2002
47
The sensitivity and specificity of clinical assessment compared with bitewing radiography for detection of occlusal dentin caries. ( 11447949 )
2001
48
[The study of histopathology and bacteriology of coronal pulp tissue in deciduous teeth with deep dentin caries]. ( 11780246 )
2000
49
Antibacterial activity of resin adhesives, glass ionomer and resin-modified glass ionomer cements and a compomer in contact with dentin caries samples. ( 11203829 )
2000
50
Molecular pathogenesis of root dentin caries. ( 10522203 )
1999

Variations for Dentin Caries

Expression for Dentin Caries

Search GEO for disease gene expression data for Dentin Caries.

Pathways for Dentin Caries

GO Terms for Dentin Caries

Cellular components related to Dentin Caries according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 myelin sheath GO:0043209 8.62 IMMT TCP1

Molecular functions related to Dentin Caries according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.17 ALPP DSPP GK IMMT INO80 TCP1

Sources for Dentin Caries

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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