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MCID: DNT010
MIFTS: 32

Dentin Caries

Categories: Gastrointestinal diseases, Oral diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Dentin Caries

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MalaCards integrated aliases for Dentin Caries:

Name: Dentin Caries 12 15
Dental Caries Extending into Dentine 12
Dental Caries Extending into Dentin 71
Compound Dental Caries 12

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases Oral diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:10461
ICD9CM 34 521.02
SNOMED-CT 67 442551007
ICD10 32 K02 K02.1
UMLS 71 C0266846
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Summaries for Dentin Caries

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MalaCards based summary : Dentin Caries, also known as dental caries extending into dentine, is related to root caries and dental caries. An important gene associated with Dentin Caries is DSPP (Dentin Sialophosphoprotein), and among its related pathways/superpathways are Degradation of the extracellular matrix and Matrix Metalloproteinases. The drugs sodium fluoride and Fluorides have been mentioned in the context of this disorder. Affiliated tissues include testes, salivary gland and colon.

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Related Diseases for Dentin Caries

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Diseases related to Dentin Caries via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 28)
# Related Disease Score Top Affiliating Genes
1 root caries 30.5 STATH DSPP
2 dental caries 30.5 STATH MMP2 DSPP
3 dental pulp necrosis 30.3 MEPE DSPP
4 pulpitis 10.5
5 enamel caries 10.4
6 hypercementosis 10.3 MMP20 DSPP
7 47,xyy 10.2
8 trichodentoosseous syndrome 10.2 MMP20 DSPP
9 arthrogryposis, distal, type 4 10.1 ZDHHC4 AWAT2
10 gingival recession 10.1 MMP8 DSPP
11 aging 10.1
12 metabolic acidosis 10.1
13 gingivitis 10.1
14 dentin sensitivity 10.1
15 candida glabrata 10.1
16 hypoxia 10.1
17 dental abscess 10.0 MEPE DSPP
18 dental fluorosis 10.0 MMP20 MMP2 DSPP
19 periapical periodontitis 9.9 MMP8 MMP2 DSPP
20 hypophosphatemic rickets, x-linked recessive 9.9 MEPE DSPP
21 tooth erosion 9.9 STATH DSPP
22 oral submucous fibrosis 9.9 MMP8 MMP2
23 dentin dysplasia 9.8 MMP20 MEPE DSPP
24 tongue carcinoma 9.8 MMP8 MMP20 MMP2
25 preterm premature rupture of the membranes 9.8 MMP8 MMP2
26 teeth hard tissue disease 9.7 STATH MMP20 DSPP
27 pelvic organ prolapse 9.6 MMP8 MMP2
28 autosomal recessive hypophosphatemic rickets 9.4 STATH MEPE DSPP

Graphical network of the top 20 diseases related to Dentin Caries:



Diseases related to Dentin Caries
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Symptoms & Phenotypes for Dentin Caries

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Drugs & Therapeutics for Dentin Caries

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Drugs for Dentin Caries (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 sodium fluoride Approved Phase 2, Phase 3 7681-49-4
2 Fluorides Phase 2, Phase 3
3 Protective Agents Phase 2, Phase 3
4 Calcium, Dietary Phase 2, Phase 3
5 Caseins Phase 2, Phase 3
6 Fluorides, Topical Phase 2, Phase 3
7 Listerine Phase 2, Phase 3
8
Calcium Nutraceutical Phase 2, Phase 3 7440-70-2 271
9 Hormones Phase 1
10 Anti-Bacterial Agents Phase 1
11
Pemetrexed Approved, Investigational 137281-23-3, 150399-23-8 60843 446556
12
leucovorin Approved 58-05-9 6006 143
13
Hydrocortisone Approved, Vet_approved 50-23-7 5754
14
Hydrocortisone acetate Approved, Vet_approved 50-03-3
15
Methamphetamine Approved, Illicit 537-46-2 10836
16
Dopamine Approved 51-61-6, 62-31-7 681
17
Petrolatum Approved, Investigational 8009-03-8
18
Salicylic acid Approved, Investigational, Vet_approved 69-72-7 338
19
Folic acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
20
Imidacloprid Vet_approved 105827-78-9 86418
21 Vitamin B Complex
22 Folic Acid Antagonists
23 Folate
24 Vitamin B9
25 Acidophilus
26 Pharmaceutical Solutions
27 Hydrocortisone 17-butyrate 21-propionate
28 Hydrocortisone hemisuccinate
29 Central Nervous System Stimulants
30 Adrenergic Agents
31 Sympathomimetics
32 Neurotransmitter Agents
33 Dopamine Agents
34 Antibiotics, Antitubercular
35 Anti-Infective Agents
36 Propolis
37 Bee Products
38 Anesthetics

Interventional clinical trials:

(show all 24)
# Name Status NCT ID Phase Drugs
1 Resin Based Composite Occlusal Restoration Postoperative Hypersensitivity: Randomized Comparative Effectiveness Research Trial Completed NCT01268605 Phase 3
2 Parental Perception of Silver Diamine Fluoride Staining and Its Efficacy on Caries Arrestment in Comparison to Sodium Fluoride With Casein Phosphopeptide-amorphous Calcium Phosphate Suspended NCT04213573 Phase 2, Phase 3 silver diamine fluoride;MI Varnish
3 Effect of Low-intensity Laser and Photodynamic Therapy on Infected Dentin of Permanent Teeth With MIH - Controlled Clinical Trial Completed NCT03826810 Phase 1
4 Antibacterial Effect of Light-activated Calcium Silicate Versus Calcium Hydroxide on Permanent Carious Molars Treated With Step-wise Excavation (A Randomized Clinical Trial) Not yet recruiting NCT03214770 Phase 1 TheraCal;light-cured calcium hydroxide
5 Effectiveness of Silver Diamine Fluoride in Arresting Dental Caries in Deciduous Molars: a Controlled and Randomized Clinical Trial Unknown status NCT03063307
6 Clinical and Digital Subtraction Radiography Evaluation of Partial Caries Removal in Primary Teeth Completed NCT01749267
7 Evaluation of the Efficacy of Er,Cr:YSGG Laser in Partial Pulpotomy Therapy of Permanent Immature Molar Teeth With Deep Dentin Caries Completed NCT04010929
8 Radiographic Assessment of Glass Ionomer Restorations With and Without Prior Application of Nano Silver Fluoride in Occlusal Carious Molars Treated With Partial Caries Removal Technique (Randomized Clinical Trial) Completed NCT03193606
9 Impact of Atraumatic Restorative Treatment Associated With Oral Health Educational Strategy on Dental Anxiety, Oral Health-related Quality of Life and Salivary Biochemical and Microbiological Characteristics of Brazilian Schoolchildren Completed NCT03100773
10 Does Virtual Reality Exposure Therapy Affect Children's Dental Anxiety, Pain, and Behaviour? A Randomized, Placebo-Controlled Cross-Over Trial Completed NCT04226651
11 Effect of Pulp Protection After Selective Carious Tissue Removal in Permanent Teeth, a Randomized Controlled Clinical Trial Recruiting NCT04250142
12 Laser Used in the Treatment of Hypomineralized Occlusal Lesions in Teeth Enamel Affected by MIH: a Randomized Controlled Clinical Study Recruiting NCT03614819
13 The Effect of Light Curable Resin Modified Glass Ionomer Varnish on Inhibiting the Progression of Non-Cavitated Proximal Carious Lesions: A Randomized Controlled Trial Recruiting NCT03685058
14 Efficacy of Resin Infiltration of Proximal Caries Tested With DIAGNOcam and Bitewing Radiography:Randomized Controlled Clinical Trial Recruiting NCT04092296
15 Effects of PArtial Excavation in One Procedure Versus Partial Excavation in Two Procedures of PRImary Deep CAries in Permanent Teeth - A Randomised, Multicenter Clinical Superiority Trial With Blinded Outcome Assessment Recruiting NCT03696498
16 A Randomized Clinical Trial of Silver Diamine Fluoride to Arrest Early Childhood Caries in Young Children Recruiting NCT04054635
17 Randomized Clinical Trial Comparison of Conventional Versus Conservative Caries Removal in Primary Teeth: a Two-year Evaluation Active, not recruiting NCT03650647
18 Oral Health and Its Relation to Growth, Development and Well-being of Schoolchildren Before and After Restorative Treatments Active, not recruiting NCT02754466
19 The Evaluation of Stepwise and One Step Excavation Techniques In The Management of Deep Dentin Lesions Active, not recruiting NCT04351048
20 Clinical Performance of MTA Cavity Lining in the Treatment of Deep Caries Lesions: A 4- Year Randomized Controlled Clinical Trial Active, not recruiting NCT04018716
21 Does the Isolation of the Operative Field Influence the Survival Rate of Bulkfill Composite Restorations in Primary Teeth Active, not recruiting NCT03733522
22 Evaluation of the Remineralizing and Antibacterial Effect of Natural Versus Synthetic Materials on Deep Carious Dentin Not yet recruiting NCT04145102
23 Effectiveness Silver Diamine Fluoride Versus Sodium Fluoride in Arresting Caries Around Crown Margins in Older Adults Not yet recruiting NCT04255251 Early Phase 1 Silver Diammine Fluoride;Fluoride Varnishes
24 Effectiveness of Atraumatic Restorative Treatment and Conventional Restorations in Primary and Permanent Dentition: A Practice-based Clinical Trial Suspended NCT02568917

Search NIH Clinical Center for Dentin Caries

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Genetic Tests for Dentin Caries

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Anatomical Context for Dentin Caries

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MalaCards organs/tissues related to Dentin Caries:

40
Testes, Salivary Gland, Colon, Bone
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Publications for Dentin Caries

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Articles related to Dentin Caries:

(show top 50) (show all 319)
# Title Authors PMID Year
1
Temporomandibular dysfunction assessment in children treated with the Hall Technique: A pilot study. 61
31991506 2020
2
Structural and Functional Characteristics of the Microbiome in Deep-Dentin Caries. 61
32196394 2020
3
A randomized clinical trial to arrest dentin caries in young children using silver diamine fluoride. 61
32428523 2020
4
In vivo performance of near-infrared light transillumination for dentine proximal caries detection in permanent teeth. 61
32405221 2020
5
Human closed and open apex premolar teeth express different toll-like receptor. 61
32400961 2020
6
Comparison between conventional and chemomechanical approaches for the removal of carious dentin: an in vitro study. 61
32415190 2020
7
Effect of silver diamine fluoride on the bond durability of normal and carious dentin. 61
32509229 2020
8
The effects of photodynamic therapy with blue light and papain-based gel associated with Urucum, on collagen and fibroblasts: a spectroscopic and cytotoxicity analysis. 61
31407100 2020
9
Clinical performance of clinical-visual examination, digital bitewing radiography, laser fluorescence, and near-infrared light transillumination for detection of non-cavitated proximal enamel and dentin caries. 61
32333336 2020
10
Diagnosis of Occlusal Caries with Dynamic Slicing of 3D Optical Coherence Tomography Images. 61
32192069 2020
11
Dentin degradonomics - The potential role of salivary MMP-8 in dentin caries. 61
32071691 2020
12
The frequency of enamel and dentin caries lesions among elderly Norwegians. 61
31267814 2020
13
The use of photodynamic therapy in the treatment of dental caries in children of contaminated areas of the ecosystem of the upper tysa region. 61
32285818 2020
14
Disinfection of Cariogenic Pathogens in Planktonic Lifestyle, Biofilm and Carious Dentine with Antimicrobial Photodynamic Therapy. 61
31483869 2020
15
Does low-cost GIC have the same survival rate as high-viscosity GIC in atraumatic restorative treatments? A RCT. 61
31994598 2020
16
Effects of Dentifrices Differing in Fluoride Content on Remineralization Characteristics of Dentin in vitro. 61
31775152 2020
17
Nanosilver Fluoride-A Paradigm Shift for Arrest in Dental Caries in Primary Teeth of Schoolchildren: A Randomized Controlled Clinical Trial. 61
32440060 2019
18
Remineralization of Natural Human Carious Dentin Lesions with an Experimental Whisker-Reinforced Atraumatic Restorative Treatment Composite. 61
29323776 2019
19
Bonding Performance of Universal Adhesive Systems Applied in Etch-and-Rinse and Self-Etch Strategies on Natural Dentin Caries. 61
31461392 2019
20
The effectiveness of curcumin-mediated antimicrobial photodynamic therapy depends on pre-irradiation and biofilm growth times. 61
31310825 2019
21
Could a chelant improve the effect of curcumin-mediated photodynamic antimicrobial chemotherapy against dental intact biofilms? 61
30604346 2019
22
Histological determination of cariously altered collagen after dentin caries excavation with the polymer bur PolyBur P1 in comparison to a conventional bud bur. 61
31307514 2019
23
Remineralization of Artificial Dentin Caries Using Dentin and Enamel Matrix Proteins. 61
31266157 2019
24
Dental caries lesions in primary teeth without obvious cavitation: Treatment decision-making process. 61
30803096 2019
25
Scientific evidence in antimicrobial photodynamic therapy: An alternative approach for reducing cariogenic bacteria. 61
30898559 2019
26
Can red fluorescence be useful in diagnostic decision making of residual dentin caries? 61
30797117 2019
27
Remineralization effects of conventional and experimental ion-releasing materials in chemically or bacterially-induced dentin caries lesions. 61
30853209 2019
28
Remineralization of demineralized dentin using a dual analog system. 61
31074152 2019
29
Glass carbomer and compomer for ART restorations: 3-year results of a randomized clinical trial. 61
30171345 2019
30
Evaluation of detecting proximal caries in posterior teeth via visual inspection, digital bitewing radiography and near-infrared light transillumination. 61
31094141 2019
31
Could chlorhexidine be an adequate positive control for antimicrobial photodynamic therapy in- in vitro studies? 61
30399454 2019
32
The impact of ICDAS on occlusal caries treatment recommendations for high caries risk patients: an in vitro study. 61
30845943 2019
33
Classification of dental diseases using hyperspectral imaging and laser induced fluorescence. 61
30500670 2019
34
Microcomputed Tomography Evaluation of Root Dentin Caries Prevention by Topical Fluorides and Potassium Iodide. 61
30791530 2019
35
[Hypoxia-dependent control of the activity of innate antimicrobial immunity in patients with dentin caries]. 61
31701931 2019
36
Long-term survival of different deep dentin caries treatments: A 5-year clinical study. 61
30666030 2019
37
Association of Enamel Caries Lesions with Oral Hygiene and DMFT among Adults. 61
30917373 2019
38
Amplicon-based microbiome study highlights the loss of diversity and the establishment of a set of species in patients with dentin caries. 61
31365560 2019
39
The Effect of Silver Diamine Fluoride in Preventing Caries in the Primary Dentition: A Systematic Review and Meta-Analysis. 61
29874642 2019
40
[Clinical and laboratory evaluation of the Elgydium Protection caries toothpaste effectiveness in patients with high intensity of dental caries]. 61
31322589 2019
41
Profile of high-fluoride toothpastes combined or not with functionalized tri-calcium phosphate on root dentin caries control: An in vitro study. 61
30658374 2018
42
Curcumin-mediated antimicrobial photodynamic therapy reduces the viability and vitality of infected dentin caries microcosms. 61
30240927 2018
43
Micro-computed tomography assessment of root dentin around fluoride-releasing restorations after demineralization/remineralization. 61
30055024 2018
44
Optical coherence tomography to evaluate variance in the extent of carious lesions in depth. 61
29725944 2018
45
Evaluation of occlusal caries detection and assessment by visual inspection, digital bitewing radiography and near-infrared light transillumination. 61
29915930 2018
46
Optical diagnosis of dentin caries lesions using quantitative light-induced fluorescence technology. 61
29807148 2018
47
Comparison of initial oral microbiomes of young adults with and without cavitated dentin caries lesions using an in situ biofilm model. 61
30228377 2018
48
Biomimetic Mineralizing Agents Recover the Micro Tensile Bond Strength of Demineralized Dentin. 61
30223511 2018
49
Three-dimensional diagnosis of dentin caries beneath composite restorations using swept-source optical coherence tomography. 61
29669953 2018
50
Microhardness and shear bond-strength of carious dentin after fluorescence-aided or conventionally excavation: (An in-vitro comparison). 61
30057709 2018
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Variations for Dentin Caries

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Expression for Dentin Caries

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Search GEO for disease gene expression data for Dentin Caries.
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Pathways for Dentin Caries

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Pathways related to Dentin Caries according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Degradation of the extracellular matrix 65
Show member pathways
 11.91 MMP8 MMP20 MMP2 DSPP
2
Matrix Metalloproteinases 1
Show member pathways
 10.79 MMP8 MMP20 MMP2
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GO Terms for Dentin Caries

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Cellular components related to Dentin Caries according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 STATH MMP8 MMP20 MMP2 MEPE DSPP
2 extracellular matrix GO:0031012 9.02 MMP8 MMP20 MMP2 MEPE DSPP

Biological processes related to Dentin Caries according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.72 SENP7 MMP8 MMP20 MMP2 CPB1
2 extracellular matrix organization GO:0030198 9.56 MMP8 MMP20 MMP2 DSPP
3 endodermal cell differentiation GO:0035987 9.37 MMP8 MMP2
4 extracellular matrix disassembly GO:0022617 9.33 MMP8 MMP20 MMP2
5 collagen catabolic process GO:0030574 9.13 MMP8 MMP20 MMP2
6 biomineral tissue development GO:0031214 8.8 STATH MEPE DSPP

Molecular functions related to Dentin Caries according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.35 SENP7 MMP8 MMP20 MMP2 CPB1
2 metalloendopeptidase activity GO:0004222 9.33 MMP8 MMP20 MMP2
3 metallopeptidase activity GO:0008237 8.92 MMP8 MMP20 MMP2 CPB1
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Sources for Dentin Caries

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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