Aliases & Classifications for Dentin Sensitivity

MalaCards integrated aliases for Dentin Sensitivity:

Name: Dentin Sensitivity 12 55 44 15 73
Sensitive Dentin 12

Classifications:



External Ids:

Disease Ontology 12 DOID:698
MeSH 44 D003807
NCIt 50 C50778
SNOMED-CT 68 13468005
UMLS 73 C0011432

Summaries for Dentin Sensitivity

MalaCards based summary : Dentin Sensitivity, also known as sensitive dentin, is related to physical urticaria and dental pulp disease, and has symptoms including toothache An important gene associated with Dentin Sensitivity is DSPP (Dentin Sialophosphoprotein), and among its related pathways/superpathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and CREB Pathway. The drugs sodium fluoride and Etodolac have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and bone, and related phenotypes are behavior/neurological and integument

Related Diseases for Dentin Sensitivity

Diseases related to Dentin Sensitivity via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 physical urticaria 10.5 TRPV1 TRPV3
2 dental pulp disease 10.4 DSPP TRPV1
3 migraine with or without aura 1 10.2 TRPA1 TRPM8 TRPV1
4 paine syndrome 10.1 TRPA1 TRPV1
5 periodontitis 10.0
6 cervicitis 9.7
7 gingivitis 9.7

Graphical network of the top 20 diseases related to Dentin Sensitivity:



Diseases related to Dentin Sensitivity

Symptoms & Phenotypes for Dentin Sensitivity

UMLS symptoms related to Dentin Sensitivity:


toothache

MGI Mouse Phenotypes related to Dentin Sensitivity:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.96 ASIC3 GJA1 KCNK2 SIX1 TRPA1 TRPM3
2 integument MP:0010771 9.81 TRPM3 TRPM8 TRPV1 TRPV3 TRPV4 ASIC3
3 nervous system MP:0003631 9.73 ASIC3 ENTPD2 GJA1 KCNK10 KCNK2 KCNK4
4 taste/olfaction MP:0005394 8.92 ENTPD2 SIX1 TRPA1 TRPV1

Drugs & Therapeutics for Dentin Sensitivity

Drugs for Dentin Sensitivity (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 100)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 sodium fluoride Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 7681-49-4
2
Etodolac Approved, Investigational, Vet_approved Phase 4 41340-25-4 3308
3
Calcium Carbonate Approved, Investigational Phase 4,Not Applicable 471-34-1
4
Hydrogen peroxide Approved, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable 7722-84-1 784
5
Glycerol Approved, Investigational Phase 4 56-81-5 753
6 Fluorides Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
7 Fluorophosphate Phase 4,Phase 3,Phase 2,Not Applicable
8 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Not Applicable
9 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
10 Anti-Infective Agents, Local Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
11 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
12 Listerine Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
13 Cariostatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
14
Tin Phase 4,Phase 3,Not Applicable 7440-31-5
15 Analgesics Phase 4,Phase 3,Not Applicable
16 Fluorides, Topical Phase 4,Phase 3,Phase 1,Not Applicable
17 Gastrointestinal Agents Phase 4,Not Applicable
18 Cyclooxygenase 2 Inhibitors Phase 4,Not Applicable
19 Cyclooxygenase Inhibitors Phase 4,Phase 3,Not Applicable
20 Analgesics, Non-Narcotic Phase 4,Phase 3,Not Applicable
21 Tin Fluorides Phase 4,Phase 3,Not Applicable
22 Antacids Phase 4,Not Applicable
23 Pharmaceutical Solutions Phase 4,Phase 2,Not Applicable
24 Anti-Inflammatory Agents Phase 4,Phase 3,Not Applicable
25 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Not Applicable
26 Anti-Ulcer Agents Phase 4,Not Applicable
27 Antirheumatic Agents Phase 4,Phase 3,Not Applicable
28 Bone Density Conservation Agents Phase 4,Phase 2,Phase 1,Not Applicable
29 Calcium, Dietary Phase 4,Phase 2,Phase 1,Not Applicable
30 arginine Nutraceutical Phase 4,Phase 3,Not Applicable
31
Dopamine Approved Phase 2, Phase 3 51-61-6, 62-31-7 681
32
Methamphetamine Approved, Illicit Phase 2, Phase 3 537-46-2 10836
33
Ketorolac Approved Phase 3 74103-06-3, 66635-83-4 3826
34
Acetaminophen Approved Phase 3 103-90-2 1983
35
Silicon Approved, Investigational Phase 3 7440-21-3 4082203
36
Piroxicam Approved, Investigational Phase 3 36322-90-4 5280452 54676228
37
Triclosan Approved, Investigational Phase 3 3380-34-5 5564
38
Betadex Experimental Phase 3 7585-39-9 320761
39 Adrenergic Agents Phase 2, Phase 3
40 Central Nervous System Stimulants Phase 2, Phase 3
41 Neurotransmitter Agents Phase 2, Phase 3,Not Applicable
42 Neurotransmitter Uptake Inhibitors Phase 2, Phase 3
43 Dopamine Agents Phase 2, Phase 3
44 Dopamine Uptake Inhibitors Phase 2, Phase 3
45 Autonomic Agents Phase 2, Phase 3,Not Applicable
46 Micronutrients Phase 3
47 Trace Elements Phase 3
48 Hypolipidemic Agents Phase 3
49 Piroxicam-beta-cyclodextrin Phase 3
50 Ketorolac Tromethamine Phase 3

Interventional clinical trials:

(show top 50) (show all 141)
# Name Status NCT ID Phase Drugs
1 The Efficacy of Cyanoacrylate Adhesive (PeriAcryl®90 HV) in Periodontal Wound Healing Unknown status NCT02826109 Phase 4
2 Efficacy of Two Oral Hygiene Regimens in the Reduction of Dentin Hypersensitivity After Periodontal Treatment Completed NCT02461030 Phase 4 In-office and at home Colgate sensitive pro-relief - CSPR;In-office Villevie® prophy paste + Colgate Toothpaste
3 Clinical Study of the Whitening Dentifrices on Tooth Color and Sensitivity Completed NCT02483013 Phase 4
4 The Effect of Desensitizing Agents in In-home or In-office Dental Bleaching Completed NCT02316080 Phase 4
5 Nano-hydroxyapatite With Potassium Nitrate in the Therapy of the Dental Sensitivity Completed NCT02895321 Phase 4
6 Study to Investigate the Efficacy of an Occluding Dentifrice in Providing Relief From Dentine Hypersensitivity Completed NCT02773758 Phase 4
7 Etodolac and Post-bleaching Sensitivity Completed NCT02881619 Phase 4 Etodolac;Placebo
8 Longevity and Effectiveness of Bleaching in Healthy and Smokers Patients Completed NCT02017873 Phase 4 Peroxide Carbamide 10% - Dental bleaching treatment
9 To Investigate the Efficacy of an Occluding Dentifrice in Dentinal Hypersensitivity (DH) Completed NCT02923895 Phase 4
10 Short Term Clinical Study Investigating the Efficacy of an Occluding Dentifrice in Providing Relief From Dentinal Hypersensitivity Completed NCT02731833 Phase 4
11 Dose Response of a Tubule Occlusion Agent Completed NCT01075256 Phase 4
12 Clinical Effectiveness of In-office Bleaching Activated With a LED/Laser Device Completed NCT01231243 Phase 4
13 Efficacy of a Whitening Dentifrice on Tooth Discoloration Completed NCT02741427 Phase 4
14 Effectiveness of Nanohydroxyapetite Paste on Reducing Dentin Hypersensitivity Recruiting NCT02936830 Phase 4 5% Sodium Fluoride Varnish;15% Nanohydroxyapetite paste;Glycerol
15 Combined Bleaching Technique: Efficacy and Tooth Sensitivity Active, not recruiting NCT03089216 Phase 4 8% arginine and calcium carbonate
16 Combined Dental Bleaching Protocols and Time Required to Achieve Satisfactory Color Enrolling by invitation NCT03514797 Phase 4 Bleaching Agents;Bleaching Agents
17 Effectiveness of Arginin and Potassium Nitrate Dentifrices in Dentin Hypersensitivity Therapy Unknown status NCT02829879 Phase 3 8% arginine/1450ppm sodium monofluorophosphate dentifrice;5% potassium nitrate/2500ppm sodium fluoride dentifrice
18 Evaluation of Dentin Hypersensitivity Using Glass Ionomer Cements Unknown status NCT02378129 Phase 2, Phase 3 Resin-modified glass ionomer cement Clinpro XT;Glass Ionomer cement Vidrion R
19 Dentin Treatments for Restorations of Cervical Lesions Non-Carious Unknown status NCT02434601 Phase 2, Phase 3
20 Effectiveness of a Homecare Dentin Hypersensitivity Gel Completed NCT02128633 Phase 2, Phase 3 placebo gel;5% sodium fluoride, potassium oxalate 5%, strontium chloride 10%;Fluoride neutral NaF gel 2 %
21 Piroxicam-beta-Cyclodextrin on Tooth Sensitivity Caused by In-office Bleaching Completed NCT03153657 Phase 3 Piroxicam-Beta-Cyclodextrin;Placebo
22 Cyanoacrylate and Laser and Dentin Sensitivity Completed NCT01111474 Phase 3
23 IN-OFFICE TOOTH BLEACHING WITH 37% CARBAMIDE PEROXIDE Completed NCT02935114 Phase 3 37% Carbamide Peroxide;35% hydrogen Peroxide
24 The Effect of Different Drugs in the Prevention of Tooth Sensitivity Caused by Tooth Bleaching Treatment. Completed NCT03343392 Phase 3 acetam/ketoro tromet group;Placebo group
25 Investigating the Efficacy of an Occluding Dentifrice in Providing Relief From Dentinal Hypersensitivity Completed NCT02832375 Phase 3 stannous fluoride;sodium monofluorophosphate
26 Investigating the Efficacy of a Dentifrice in Providing Long Term Relief From Dentinal Hypersensitivity Completed NCT01827670 Phase 3 Stannous fluoride;Sodium monofluorophosphate
27 The Efficacy of a Dentifrice in Providing Relief From Immediate and Short Term Relief From Dentinal Hypersensitivity Completed NCT03072719 Phase 3 Stannous Fluoride;Sodium Monofluorophosphate
28 The Efficacy of a Dentifrice in Providing Relief From the Pain of Dentinal Hypersensitivity Completed NCT01592864 Phase 3 Stannous Fluoride;Sodium Monofluorophosphate
29 Clinical Efficacy of a Toothpaste in Providing Relief From the Pain of Dentinal Hypersensitivity Completed NCT01592851 Phase 3 Stannous Fluoride;Sodium Monofluorophosphate
30 The Efficacy of a Toothpaste to Reduce Sensitivity Completed NCT00763269 Phase 3 Triclosan, Silicon dioxide, fluoride;Triclosan, fluoride
31 Comparison of Different Desensitizers in Reducing Dentinal Hypersensitivity Recruiting NCT03177109 Phase 3 5% fluoride varnish;8% arginine containing paste;Self-adhesive resin
32 The Role of Biodentine in Class V Dental Lesions on Oral Health Related Quality of Life Recruiting NCT03304184 Phase 3
33 Clinical Efficacy in Relieving Dentin Hypersensitivity of Nanohydroxyapatite-Containing Toothpastes and Cream Completed NCT02918617 Phase 2 Control toothpaste containing Novamin® technology;Control toothpaste containing 1500 ppm fluoride as MFP;Test toothpaste with nano-HAP (high concentration);Test toothpaste with nano-HAP (low concentration);Test toothpaste with nano-HAP and KNO3;Control toothpaste without nano-HAP;Test toothpaste with nano-HAP (medium concentration);Test cream with nano-HAP (higher concentration);Control cream without nano-HAP
34 Efficacy of Potassium Nitrate Solution in Reducing Dentinal Hypersensitivity Completed NCT01115452 Phase 2 5% Potassium nitrate;2.5% Potassium nitrate
35 Different Concentrations of Potassium Nitrate in In-office Tooth Bleaching Sensitivity Completed NCT03323372 Phase 2 3% potassium nitrate and 0.25% sodium fluoride;5% potassium nitrate and 2% sodium fluoride
36 Clinical Study Investigating the Efficacy of a Mouthwash in Providing Long Term Relief From Dentinal Hypersensitivity Completed NCT02226562 Phase 2 Potassium nitrate and sodium fluoride;Standard fluoride dentifrice
37 Exploratory Study to Evaluate an Occlusion Based Dentifrice in Relief of Dentinal Hypersensitivity Completed NCT01691560 Phase 2 5% calcium sodium phosphosilicate/ sodium monofluorophosphate dentifrice;0% calcium sodium phosphosilicate/sodium monofluorophosphate dentifrice;Sodium monofluorophosphate dentifrice;Sodium fluoride dentifrice
38 Exploratory Study to Evaluate the Efficacy of an Occlusion Based Dentifrice in Relief of Dentinal Hypersensitivity Completed NCT01831817 Phase 2 5% calcium sodium phosphosilicate/ sodium monofluorophosphate dentifrice;0% calcium sodium phosphosilicate/ sodium monofluorophosphate dentifrice;Sodium monofluorophosphate dentifrice;Sodium Fluoride dentifrice
39 Clinical Performance of 3-Unit FPDs Completed NCT00223431 Phase 2
40 Comparison Of Clinical Efficacy Of A Herbal And A Non-Herbal Mouthwash On Dentinal Hypersensitivity Completed NCT02008500 Phase 2
41 A Clinical Method Development Study to Characterise The Efficacy of a Dentifrice For The Relief Of Dentin Hypersensitivity Not yet recruiting NCT03361774 Phase 2 Dentifrice containing 5% w/w KNO3 and 0.454% w/w SnF2 (1100 ppm fluoride).;Dentifrice containing 0.454% w/w SnF2 (1100 ppm fluoride).
42 Effect of Laser and Potassium Nitrate Application on the Sensitivity Control in Bleached Teeth Completed NCT03434782 Phase 1 In-office dental bleaching;Low Level Laser Therapy;5% potassium nitrate / 2% sodium fluoride gel
43 Evaluation of the Effect of Fluoride and Laser Application on the Prevention of Sensitivity in Bleached Teeth Completed NCT03044171 Phase 1 1.1% Sodium Fluoride;In-office dental bleaching
44 Pharmacokinetics of Diammine Silver Fluoride Completed NCT01664871 Phase 1
45 Effectiveness of Bioactiveglass Air Abrasion Versus Fluoride Varnish in Management of Dentin Hypersensitivity Not yet recruiting NCT03285360 Phase 1
46 Effects of DIammine SIlver Fluoride on Tooth Sensitivity Unknown status NCT01063530 Not Applicable
47 Randomized Controlled Trial of a Novel Laser-aided Orthodontic-periodontal Treatment Strategy Unknown status NCT02352038 Not Applicable
48 The Efficacy and Safety of Tooth Bleaching Procedure Using Y10 Whitening Toothpaste and RF Current Unknown status NCT02841514 Not Applicable
49 Clinical Benefit of a Mouthrinse for the Treatment of Dentine Hypersensitivity Completed NCT03232255 Not Applicable
50 Clinical Trial to Compare the Efficacy of a Fluoride Gel and a Dental Bonding Agent in Treatment of Tooth Sensitivity Completed NCT02919202 Not Applicable

Search NIH Clinical Center for Dentin Sensitivity

Cochrane evidence based reviews: dentin sensitivity

Genetic Tests for Dentin Sensitivity

Anatomical Context for Dentin Sensitivity

MalaCards organs/tissues related to Dentin Sensitivity:

41
Testes, Brain, Bone

Publications for Dentin Sensitivity

Articles related to Dentin Sensitivity:

(show all 27)
# Title Authors Year
1
Comparing the effect of a desensitizing material and a self-etch adhesive on dentin sensitivity after periodontal surgery: a randomized clinical trial. ( 28808633 )
2017
2
Randomized trial of the clinical efficacy of a potassium oxalate-containing mouthrinse in rapid relief of dentin sensitivity. ( 24282871 )
2013
3
Biomimetic mineralization: long-term observations in patients with dentin sensitivity. ( 22305715 )
2012
4
Human odontoblasts express functional thermo-sensitive TRP channels: implications for dentin sensitivity. ( 21168271 )
2011
5
Oxalic acid under adhesive restorations as a means to reduce dentin sensitivity: a four-month clinical trial. ( 21777095 )
2011
6
[Dentin sensitivity: an oral symptom that should not be neglected]. ( 19575978 )
2009
7
Considerations for the development of over-the-counter dentifrices for the treatment and relief of dentin sensitivity. ( 19902641 )
2009
8
Clinical evaluation of cervical dentin sensitivity (CDS) in patients attending general dental clinics (GDC) and periodontal specialty clinics (PSC). ( 11908469 )
2002
9
Root-dentin sensitivity following non-surgical periodontal treatment. ( 10983603 )
2000
10
The Dentin Disc surface: a plausible model for dentin physiology and dentin sensitivity evaluation. ( 9470509 )
1997
11
[Treatment of dentin sensitivity with stannous fluoride gel. Electron microscopic study and evaluation of dentin permeability]. ( 9567615 )
1997
12
Theory of dentin sensitivity. ( 8534375 )
1994
13
Dental pain evoked by hydrostatic pressures applied to exposed dentin in man: a test of the hydrodynamic theory of dentin sensitivity. ( 7996085 )
1994
14
Dentin permeability and dentin sensitivity. ( 1508886 )
1992
15
Relation of dentin sensitivity to histological changes in dog teeth with exposed and stimulated dentin. ( 1508867 )
1992
16
An in vivo study of dentin sensitivity: the relation of dentin sensitivity and the patency of dentin tubules. ( 1753319 )
1991
17
Evaluation of tartar control dentifrices in in vitro models of dentin sensitivity. ( 1650304 )
1991
18
The influence of frequent ingestion of acids in the diet on treatment for dentin sensitivity. ( 2285881 )
1990
19
Mechanisms of dentin sensitivity. ( 2197121 )
1990
20
Double-blind evaluation of duration of dentin sensitivity reduction by fluoride iontophoresis. ( 2638286 )
1989
21
The efficacy of a new dentifrice in treating dentin sensitivity: effects of sodium citrate and sodium fluoride as active ingredients. ( 2953887 )
1987
22
Dentin permeability, dentin sensitivity, and treatment through tubule occlusion. ( 3465852 )
1986
23
Dentin sensitivity: a review. ( 3860500 )
1985
24
Clinical evaluation of the effectiveness of three dentifrices in relieving dentin sensitivity. ( 6596425 )
1984
25
Dentin sensitivity, odontoblasts and nerves under desiccated or infected experimental cavities. A clinical, light microscopic and ultrastructural investigation. ( 6955990 )
1982
26
Dentin sensitivity and aspiration of odontoblasts. ( 14014982 )
1963
27
Sodium fluoride therapy for combating dentin sensitivity and gingival decay. ( 21008391 )
1945

Variations for Dentin Sensitivity

Expression for Dentin Sensitivity

Search GEO for disease gene expression data for Dentin Sensitivity.

Pathways for Dentin Sensitivity

Pathways related to Dentin Sensitivity according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.99 ASIC3 TRPA1 TRPM3 TRPM8 TRPV1 TRPV2
2
Show member pathways
12.96 TRPM3 TRPM8 TRPV1 TRPV2 TRPV3 TRPV4
3
Show member pathways
12.29 ASIC3 TRPA1 TRPM8 TRPV1 TRPV2 TRPV3
4
Show member pathways
12.05 ASIC3 TRPA1 TRPM3 TRPM8 TRPV1 TRPV2
5
Show member pathways
11.71 KCNK10 KCNK2 KCNK4
6
Show member pathways
11.59 KCNK10 KCNK2 KCNK4
7 10.57 TRPA1 TRPM3 TRPM8 TRPV1 TRPV2 TRPV3

GO Terms for Dentin Sensitivity

Cellular components related to Dentin Sensitivity according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.97 ASIC3 ENTPD2 GJA1 KCNK10 KCNK2 KCNK4
2 plasma membrane GO:0005886 9.77 ASIC3 ENTPD2 GJA1 KCNK10 KCNK2 KCNK4
3 integral component of plasma membrane GO:0005887 9.32 ASIC3 GJA1 KCNK10 KCNK2 KCNK4 TRPA1

Biological processes related to Dentin Sensitivity according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.97 CSN3 GJA1 TRPA1 TRPM3 TRPM8 TRPV1
2 ion transmembrane transport GO:0034220 9.86 ASIC3 GJA1 TRPA1 TRPM3 TRPM8 TRPV1
3 positive regulation of cytosolic calcium ion concentration GO:0007204 9.82 GJA1 TRPV1 TRPV4
4 potassium ion transport GO:0006813 9.82 KCNK10 KCNK2 KCNK4
5 potassium ion transmembrane transport GO:0071805 9.81 KCNK10 KCNK2 KCNK4
6 response to heat GO:0009408 9.78 ASIC3 TRPV1 TRPV2 TRPV3
7 protein homotetramerization GO:0051289 9.77 TRPA1 TRPM8 TRPV1
8 cation transport GO:0006812 9.76 ASIC3 TRPM3 TRPM8
9 memory GO:0007613 9.74 KCNK10 KCNK2 KCNK4
10 response to mechanical stimulus GO:0009612 9.72 ASIC3 KCNK2 TRPV4
11 sensory perception of pain GO:0019233 9.71 KCNK4 TRPA1 TRPV1
12 calcium ion transport GO:0006816 9.7 TRPA1 TRPM3 TRPM8 TRPV1 TRPV2 TRPV3
13 stabilization of membrane potential GO:0030322 9.67 KCNK10 KCNK2 KCNK4
14 negative regulation of cardiac muscle cell proliferation GO:0060044 9.63 GJA1 KCNK2
15 response to pain GO:0048265 9.63 TRPA1 TRPV1
16 response to temperature stimulus GO:0009266 9.63 TRPM8 TRPV2 TRPV3
17 positive regulation of calcium ion import GO:0090280 9.62 TRPV2 TRPV3
18 detection of temperature stimulus involved in sensory perception of pain GO:0050965 9.62 ASIC3 TRPV1
19 sensory perception GO:0007600 9.61 ASIC3 TRPV2
20 negative regulation of DNA biosynthetic process GO:2000279 9.61 GJA1 KCNK2
21 sensory perception of temperature stimulus GO:0050951 9.61 KCNK4 TRPM3 TRPM8
22 response to pH GO:0009268 9.6 GJA1 TRPV1
23 detection of mechanical stimulus involved in sensory perception of pain GO:0050966 9.58 ASIC3 TRPA1
24 detection of chemical stimulus involved in sensory perception of pain GO:0050968 9.58 ASIC3 TRPA1 TRPV1
25 diet induced thermogenesis GO:0002024 9.56 TRPV1 TRPV4
26 thermoception GO:0050955 9.54 TRPA1 TRPM8 TRPV1
27 cellular response to temperature stimulus GO:0071502 9.52 KCNK4 TRPV1
28 detection of temperature stimulus GO:0016048 9.51 TRPM3 TRPM8
29 calcium ion transmembrane transport GO:0070588 9.5 TRPA1 TRPM3 TRPM8 TRPV1 TRPV2 TRPV3
30 ion transport GO:0006811 9.36 ASIC3 KCNK10 KCNK2 KCNK4 TRPA1 TRPM3

Molecular functions related to Dentin Sensitivity according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion channel activity GO:0005216 9.62 TRPV1 TRPV2 TRPV3 TRPV4
2 potassium channel activity GO:0005267 9.54 KCNK10 KCNK2 KCNK4
3 ion transmembrane transporter activity GO:0015075 9.43 GJA1 TRPV2
4 cation channel activity GO:0005261 9.43 ASIC3 TRPM3 TRPV1 TRPV2 TRPV3 TRPV4
5 calcium-release channel activity GO:0015278 9.4 TRPA1 TRPV1
6 potassium ion leak channel activity GO:0022841 9.33 KCNK10 KCNK2 KCNK4
7 temperature-gated cation channel activity GO:0097604 9.26 KCNK4 TRPA1
8 calcium channel activity GO:0005262 9.17 TRPA1 TRPM3 TRPM8 TRPV1 TRPV2 TRPV3

Sources for Dentin Sensitivity

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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