MCID: DNT002
MIFTS: 24

Dentine Erosion

Categories: Oral diseases

Aliases & Classifications for Dentine Erosion

MalaCards integrated aliases for Dentine Erosion:

Name: Dentine Erosion 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:13629
ICD9CM 36 521.32
UMLS 74 C1456162

Summaries for Dentine Erosion

MalaCards based summary : Dentine Erosion is related to enamel caries and amelogenesis imperfecta, type ib. An important gene associated with Dentine Erosion is GPI (Glucose-6-Phosphate Isomerase). Related phenotypes are no effect and Increased cell death HMECs cells

Related Diseases for Dentine Erosion

Graphical network of the top 20 diseases related to Dentine Erosion:



Diseases related to Dentine Erosion

Symptoms & Phenotypes for Dentine Erosion

GenomeRNAi Phenotypes related to Dentine Erosion according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 9.92 AMBN AMELX ATP7B BMP2 BMP3 BRD1
2 Increased cell death HMECs cells GR00103-A-0 9.35 BMP3 BRD1 CUL3 SMARCA2 TYRO3

MGI Mouse Phenotypes related to Dentine Erosion:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.22 AMBN ATP7B BMP2 BRD1 CUL3 ENAM
2 hematopoietic system MP:0005397 10.15 ATP7B BMP2 BRD1 ENAM GPI MMP2
3 homeostasis/metabolism MP:0005376 10.13 ATP7B BMP2 CUL3 ENAM GPI MMP2
4 immune system MP:0005387 10 ATP7B BMP2 GPI MMP2 MTF1 PLA2G15
5 craniofacial MP:0005382 9.98 AMBN BMP2 ENAM MMP2 MTF1 SMARCA4
6 liver/biliary system MP:0005370 9.76 ATP7B BRD1 CUL3 GPI MTF1 PLA2G15
7 neoplasm MP:0002006 9.43 AMBN MMP2 MTF1 SMARCA2 SMARCA4 TNFSF11
8 skeleton MP:0005390 9.28 AMBN BMP2 BMP3 ENAM MMP2 SMARCA2

Drugs & Therapeutics for Dentine Erosion

Search Clinical Trials , NIH Clinical Center for Dentine Erosion

Genetic Tests for Dentine Erosion

Anatomical Context for Dentine Erosion

Publications for Dentine Erosion

Articles related to Dentine Erosion:

(show all 14)
# Title Authors Year
1
Preventive effect of toothpastes with MMP inhibitors on human dentine erosion and abrasion in vitro. ( 27008258 )
2016
2
Impact of Sn/F Pre-Treatments on the Durability of Protective Coatings against Dentine Erosion/Abrasion. ( 26075906 )
2015
3
The role of matrix metalloproteinases and cysteine-cathepsins on the progression of dentine erosion. ( 26134516 )
2015
4
Evaluation of the effects of two novel irrigants on intraradicular dentine erosion, debris and smear layer removal. ( 26295025 )
2015
5
Prevention of dentine erosion by brushing with anti-erosive toothpastes. ( 24704085 )
2014
6
The effect of casein phosphopeptide-amorphous calcium phosphate paste and sodium fluoride mouthwash on the prevention of dentine erosion: An in vitro study. ( 24944448 )
2014
7
Anacardic acid from brazilian cashew nut trees reduces dentine erosion. ( 24993776 )
2014
8
Effect of a pulsed CO2 laser and fluoride on the prevention of enamel and dentine erosion. ( 20031117 )
2010
9
Effect of two restorative materials on root dentine erosion. ( 20225213 )
2010
10
Effect of iron on matrix metalloproteinase inhibition and on the prevention of dentine erosion. ( 20551644 )
2010
11
Impact of the in situ formed salivary pellicle on enamel and dentine erosion induced by different acids. ( 18607835 )
2008
12
Effect of an iron mouthrinse on enamel and dentine erosion subjected or not to abrasion: an in situ/ex vivo study. ( 17045952 )
2007
13
Influence of the organic matrix on root dentine erosion by citric acid. ( 15741726 )
2005
14
The effect of saliva on enamel and dentine erosion. ( 10377607 )
1999

Variations for Dentine Erosion

Expression for Dentine Erosion

Search GEO for disease gene expression data for Dentine Erosion.

Pathways for Dentine Erosion

GO Terms for Dentine Erosion

Cellular components related to Dentine Erosion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 9.62 AMELX ENAM MMP2 TFIP11
2 extracellular space GO:0005615 9.61 BMP2 BMP3 CPM GPI MMP2 PLA2G15
3 extracellular region GO:0005576 9.4 AMBN AMELX BMP2 BMP3 CPM ENAM
4 SWI/SNF complex GO:0016514 9.37 SMARCA2 SMARCA4
5 nBAF complex GO:0071565 9.26 SMARCA2 SMARCA4
6 npBAF complex GO:0071564 9.16 SMARCA2 SMARCA4

Biological processes related to Dentine Erosion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.71 AMBN AMELX CUL3 ENAM
2 regulation of signaling receptor activity GO:0010469 9.63 AMBN AMELX BMP2 BMP3 GPI TNFSF11
3 cellular protein metabolic process GO:0044267 9.56 AMBN AMELX ENAM MMP2
4 osteoblast differentiation GO:0001649 9.54 AMELX BMP2 BMP3
5 ossification GO:0001503 9.5 BMP2 BMP3 TNFSF11
6 response to immobilization stress GO:0035902 9.43 BRD1 GPI
7 odontogenesis of dentin-containing tooth GO:0042475 9.26 AMBN AMELX BMP2 ENAM
8 biomineral tissue development GO:0031214 9.02 AMBN AMELX ENAM TFIP11 TUFT1

Molecular functions related to Dentine Erosion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.56 BMP2 BMP3 GPI TNFSF11
2 histone binding GO:0042393 9.54 BRD1 SMARCA2 SMARCA4
3 growth factor activity GO:0008083 9.35 AMBN AMELX BMP2 BMP3 GPI
4 BMP receptor binding GO:0070700 9.32 BMP2 BMP3
5 hydrolase activity, acting on acid anhydrides GO:0016817 9.16 SMARCA2 SMARCA4
6 structural constituent of tooth enamel GO:0030345 8.92 AMBN AMELX ENAM TUFT1

Sources for Dentine Erosion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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