MCID: DNT048
MIFTS: 12

Dentinogenesis Imperfecta Type 3

Categories: Bone diseases, Genetic diseases, Oral diseases, Rare diseases

Aliases & Classifications for Dentinogenesis Imperfecta Type 3

MalaCards integrated aliases for Dentinogenesis Imperfecta Type 3:

Name: Dentinogenesis Imperfecta Type 3 54
Brandywine Type Dentinogenesis Imperfecta 54
Dentinogenesis Imperfecta, Shields Type 3 54
Dentinogenesis Imperfecta Shields Type 3 54
Dentinogenesis Imperfecta Type Iii 54

Classifications:



Summaries for Dentinogenesis Imperfecta Type 3

NIH Rare Diseases : 54 Dentinogenesis imperfecta type 3 is a rare and severe form of dentinogenesis imperfecta, a condition that affects tooth development. People affected by this condition generally have discolored (most often a blue-gray or yellow-brown color) and translucent teeth. Teeth are also weaker than normal, making them prone to rapid wear, breakage, and loss. These problems can affect both primary (baby) teeth and permanent teeth. Dentinogenesis imperfecta type 3 is caused by changes (mutations) in the DSPP gene which are inherited in an autosomal dominant manner. Treatment is usually focused on protecting primary (baby) and then permanent teeth with preformed pediatric crowns and other interventions. The replacement of teeth might be considered in the future with dentures and/or implants.

MalaCards based summary : Dentinogenesis Imperfecta Type 3, also known as brandywine type dentinogenesis imperfecta, is related to dentinogenesis imperfecta and dentinogenesis imperfecta, shields type iii. Affiliated tissues include bone.

Related Diseases for Dentinogenesis Imperfecta Type 3

Diseases in the Dentinogenesis Imperfecta family:

Dentinogenesis Imperfecta 1 Dentinogenesis Imperfecta Type 2
Dentinogenesis Imperfecta Type 3

Diseases related to Dentinogenesis Imperfecta Type 3 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 dentinogenesis imperfecta 11.7
2 dentinogenesis imperfecta, shields type iii 11.4

Symptoms & Phenotypes for Dentinogenesis Imperfecta Type 3

Drugs & Therapeutics for Dentinogenesis Imperfecta Type 3

Search Clinical Trials , NIH Clinical Center for Dentinogenesis Imperfecta Type 3

Genetic Tests for Dentinogenesis Imperfecta Type 3

Anatomical Context for Dentinogenesis Imperfecta Type 3

MalaCards organs/tissues related to Dentinogenesis Imperfecta Type 3:

42
Bone

Publications for Dentinogenesis Imperfecta Type 3

Articles related to Dentinogenesis Imperfecta Type 3:

# Title Authors Year
1
Dentin phosphoprotein compound mutation in dentin sialophosphoprotein causes dentinogenesis imperfecta type III. ( 15690376 )
2005
2
Dentin sialophosphoprotein knockout mouse teeth display widened predentin zone and develop defective dentin mineralization similar to human dentinogenesis imperfecta type III. ( 12721295 )
2003
3
Genetic linkage of the dentinogenesis imperfecta type III locus to chromosome 4q. ( 10371253 )
1999
4
Dentinogenesis imperfecta type III with enamel and cementum defects. ( 2989751 )
1985

Variations for Dentinogenesis Imperfecta Type 3

Expression for Dentinogenesis Imperfecta Type 3

Search GEO for disease gene expression data for Dentinogenesis Imperfecta Type 3.

Pathways for Dentinogenesis Imperfecta Type 3

GO Terms for Dentinogenesis Imperfecta Type 3

Sources for Dentinogenesis Imperfecta Type 3

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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