MCID: DNT008
MIFTS: 40

Denture Stomatitis

Categories: Oral diseases

Aliases & Classifications for Denture Stomatitis

MalaCards integrated aliases for Denture Stomatitis:

Name: Denture Stomatitis 12 15
Stomatitis, Denture 44 73
Denture Sore Mouth 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11875
ICD10 33 K12.1
MeSH 44 D013282
SNOMED-CT 68 69254008
UMLS 73 C0038364

Summaries for Denture Stomatitis

MalaCards based summary : Denture Stomatitis, also known as stomatitis, denture, is related to stomatitis and diabetes mellitus. An important gene associated with Denture Stomatitis is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways/superpathways are IL-17 Family Signaling Pathways and Immune response IFN gamma signaling pathway. The drugs Nystatin and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include colon, neutrophil and monocytes.

Related Diseases for Denture Stomatitis

Diseases related to Denture Stomatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 123)
# Related Disease Score Top Affiliating Genes
1 stomatitis 11.2
2 diabetes mellitus 10.2
3 recurrent corneal erosion 10.2 CXCL8 IL6
4 bagassosis 10.2 CXCL8 IL6
5 acute transverse myelitis 10.2 CXCL8 IL6
6 transverse myelitis 10.2 CXCL8 IL6
7 streptococcal toxic-shock syndrome 10.2 CXCL8 IL6
8 papillary conjunctivitis 10.2 CXCL8 IL6
9 conjunctivitis 10.2 CXCL8 IL6
10 funisitis 10.2 CXCL8 IL6
11 acute monoblastic leukemia 10.2 CXCL8 IL6
12 capillary leak syndrome 10.2 CXCL8 IL6
13 meconium aspiration syndrome 10.2 CXCL8 IL6
14 louse-borne relapsing fever 10.2 CXCL8 IL6
15 endometrial disease 10.2 CXCL8 IL6
16 vaginal disease 10.2 CXCL8 IL6
17 vaginitis 10.2 CXCL8 IL6
18 necrotizing fasciitis 10.2 CXCL8 IL6
19 fasciitis 10.2 CXCL8 IL6
20 herpes simplex virus keratitis 10.2 CCL2 CXCL8
21 cowpox 10.2 CXCL8 IL6
22 israeli tick typhus 10.2 CCL2 CXCL8
23 pulpitis 10.2 CXCL8 IL6
24 middle ear disease 10.2 CXCL8 IL6
25 perinatal necrotizing enterocolitis 10.2 CXCL8 IL6
26 diabetic foot ulcers 10.2 CCL2 IL6
27 prostatitis 10.2 CXCL8 IL6
28 acute respiratory distress syndrome 10.2 CXCL8 IL6
29 pleural tuberculosis 10.2 CCL2 CXCL8
30 newborn respiratory distress syndrome 10.2 CXCL8 IL6
31 macular holes 10.2 CCL2 CXCL8
32 stachybotrys chartarum 10.2 CCL2 IL6
33 tuberculous meningitis 10.2 CCL2 CXCL8
34 hemorrhagic fever with renal syndrome 10.2 CXCL8 IL6
35 bacterial vaginosis 10.2 CXCL8 IL6
36 macular retinal edema 10.2 CCL2 IL6
37 ischemic heart disease 10.2 CCL2 IL6
38 post-thrombotic syndrome 10.2 CCL2 IL6
39 mesangial proliferative glomerulonephritis 10.2 CCL2 IL6
40 proliferative glomerulonephritis 10.2 CCL2 IL6
41 stromal keratitis 10.2 CCL2 IL6
42 interstitial cystitis 10.2 CXCL8 IL6
43 preterm premature rupture of the membranes 10.2 CXCL8 IL6
44 avian influenza 10.2 CXCL8 IL6
45 diabetic macular edema 10.2 CCL2 IL6
46 dengue shock syndrome 10.2 CCL2 IL6
47 brucellosis 10.2 CXCL8 IL6
48 complex regional pain syndrome 10.2 CCL2 IL6
49 pleurisy 10.2 CCL2 CXCL8
50 viral encephalitis 10.2 CCL2 IL6

Graphical network of the top 20 diseases related to Denture Stomatitis:



Diseases related to Denture Stomatitis

Symptoms & Phenotypes for Denture Stomatitis

Drugs & Therapeutics for Denture Stomatitis

Drugs for Denture Stomatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nystatin Approved, Vet_approved Phase 4,Phase 2 1400-61-9 11953884
2
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 22916-47-8 4189
3
Methylene blue Approved, Investigational Phase 4 61-73-4
4 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Not Applicable
5 Anti-Bacterial Agents Phase 4,Phase 2,Not Applicable
6 Ionophores Phase 4,Phase 2
7 Antifungal Agents Phase 4,Phase 3,Phase 2
8 Pharmaceutical Solutions Phase 4,Not Applicable
9 Bee Products Phase 3,Not Applicable
10 Hormones Phase 3
11 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
12 Cytochrome P-450 Enzyme Inhibitors Phase 3
13 Steroid Synthesis Inhibitors Phase 3
14 Propolis Phase 3,Not Applicable
15 Cytochrome P-450 CYP3A Inhibitors Phase 3
16 Hormone Antagonists Phase 3
17 Anti-Infective Agents, Local Phase 3,Not Applicable
18 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
19
Clotrimazole Approved, Vet_approved Phase 2 23593-75-1 2812
20 Garlic Approved, Nutraceutical Phase 2
21
Titanium dioxide Approved Phase 1,Not Applicable 13463-67-7
22 Photosensitizing Agents Phase 1,Not Applicable
23 Radiation-Protective Agents Phase 1,Not Applicable
24 Protective Agents Phase 1,Not Applicable
25 Sunscreening Agents Phase 1,Not Applicable
26 Dermatologic Agents Phase 1,Not Applicable
27
Chlorhexidine Approved, Vet_approved Not Applicable 55-56-1 2713 9552079
28
Mechlorethamine Approved, Investigational Not Applicable 51-75-2 4033
29 Chlorhexidine gluconate Not Applicable
30 Eusol Not Applicable
31 Disinfectants Not Applicable
32 Sodium hypochlorite Not Applicable
33 Antineoplastic Agents, Alkylating Not Applicable
34 Alkylating Agents Not Applicable
35 chloramine-T Not Applicable

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Photodynamic Therapy Against Candida Spp. in Complete Denture Wearers Completed NCT02642900 Phase 4 Nystatin 100.000 units
2 Efficacy of Standardized-propolis Extract (EPP-AF®) Gel Formulation as Buccal Antiseptic Completed NCT02818803 Phase 3 Miconazole
3 Effect of Aqueous Extract of Garlic and Nystatin Mouthwash in Denture Stomatitis Completed NCT01198223 Phase 2 garlic , nystatin
4 Efficacy of Slow Release Clotrimazole Varnish Treating Denture Stomatitis Comparing to Traditional Treatment of Troches Completed NCT00835029 Phase 2 Clotrimazole varnish;Clotrimazole troches
5 Surface Roughness of Heat Cured Acrylic Resin Versus Acrylic Resin With Titanium Dioxide Unknown status NCT02950584 Phase 1
6 The Effect of Palatal Brushing on Denture Stomatitis Completed NCT01643876 Phase 1
7 Effects of Denture-Related Stomatitis on Blood Pressure in Denture Wearers Unknown status NCT02166450 Nystatin
8 Microbiological Study on Maxillary Complete Dentures of Two Different Materials Unknown status NCT02950623 Not Applicable
9 The Effectiveness of Palatal Brushing on Denture Stomatitis Completed NCT02686632 Not Applicable
10 Hygiene Protocol of Complete Dentures Completed NCT01906242 Not Applicable
11 Experimental Denture Pastes Completed NCT01237795 Not Applicable
12 Efficacy of a Propolis-based Denture Cleanser Completed NCT01237782 Not Applicable Denture soaking solution;Saline solution
13 Novel Coating to Minimize Bacterial Adhesions and Tooth Wear in Denture Acrylic Recruiting NCT02834832
14 The Anti-microbial Effect of Titanium Dioxide Nano Particles in Complete Dentures Made for Edentulous Patients Not yet recruiting NCT03666195 Not Applicable

Search NIH Clinical Center for Denture Stomatitis

Cochrane evidence based reviews: stomatitis, denture

Genetic Tests for Denture Stomatitis

Anatomical Context for Denture Stomatitis

MalaCards organs/tissues related to Denture Stomatitis:

41
Colon, Neutrophil, Monocytes, Lung, Bone, Spinal Cord, Placenta

Publications for Denture Stomatitis

Articles related to Denture Stomatitis:

(show top 50) (show all 263)
# Title Authors Year
1
Characterization of Herbal Antifungal Agent, <i>Origanum vulgare</i> against Oral <i>Candida</i> spp. Isolated from Patients with <i>Candida</i>-Associated Denture Stomatitis: An <i>In vitro</i> Study. ( 29962756 )
2018
2
Role of laser or photodynamic therapy in treatment of denture stomatitis: A systematic review. ( 29807743 )
2018
3
Management of denture stomatitis: a narrative review. ( 29460527 )
2018
4
Cytokine gene polymorphism in denture stomatitis patients: A clinical study. ( 29423993 )
2018
5
Photodynamic inactivation of Candida ssp. on denture stomatitis. A clinical trial involving palatal mucosa and prosthesis disinfection. ( 29678677 )
2018
6
In Vitro Antifungal Susceptibility of <i>Candida</i> Species Isolated from Iranian Patients with Denture Stomatitis. ( 29888258 )
2018
7
The severity of denture stomatitis as related to risk factors and different Candida spp. ( 29759652 )
2018
8
Properties of an acrylic resin after immersion in antiseptic soaps: Low-cost, easy-access procedure for the prevention of denture stomatitis. ( 30161256 )
2018
9
Differential Mucosal Gene Expression Patterns in Candida-Associated, Chronic Oral Denture Stomatitis. ( 30536831 )
2018
10
In-vitro antifungal efficacy of tissue conditioner-chitosan composites as potential treatment therapy for denture stomatitis. ( 30543887 )
2018
11
Efficacy of Propolis on the Denture Stomatitis Treatment in Older Adults: A Multicentric Randomized Trial. ( 28396692 )
2017
12
Inhibitory effect of zirconium oxide nanoparticles on Candida albicans adhesion to repaired polymethyl methacrylate denture bases and interim removable prostheses: a new approach for denture stomatitis prevention. ( 28814859 )
2017
13
Surface Roughness Changes in Denture Liners in Denture Stomatitis Patients. ( 29084304 )
2017
14
Characterization of a novel antibiofilm effect of nitric oxide-releasing aspirin (NCX-4040) on Candida albicans isolates from denture stomatitis patients. ( 28493889 )
2017
15
Phagocytosis and nitric oxide production by peritoneal adherent cells in response to Candida albicans in aging: a collaboration to elucidate the pathogenesis of denture stomatitis. ( 28678945 )
2017
16
Denture Stomatitis: Causes, Cures and Prevention. ( 29258641 )
2017
17
In Vitro Evaluation of the Inhibitory Activity of Thymoquinone in Combatting Candida albicans in Denture Stomatitis Prevention. ( 28698449 )
2017
18
Antimicrobial Photodynamic Therapy mediated by Photodithazine<sup>Ar</sup>in the treatment of denture stomatitis: a case report. ( 29198763 )
2017
19
Oral Candida carriage and species prevalence in denture stomatitis patients with and without diabetes. ( 28685534 )
2017
20
Nystatin and disinfectant solutions seem to be effective in treating denture stomatitis. ( 28242007 )
2017
21
Laboratory-Based Investigation of Denture Sonication Method in Patients with Candida-Associated Denture Stomatitis. ( 28872720 )
2017
22
Efficacy of photodynamic therapy in the inactivation of oral fungal colonization among cigarette smokers and non-smokers with denture stomatitis. ( 28130176 )
2017
23
Candida albicans biofilm heterogeneity does not influence denture stomatitis, but strongly influences denture cleansing capacity. ( 28032543 )
2016
24
Evidence Regarding the Treatment of Denture Stomatitis. ( 27062660 )
2016
25
Fabrication and Evaluation of Nanostructured Herbal Oil/Hydroxypropyl-I^-Cyclodextrin/Polyvinylpyrrolidone Mats for Denture Stomatitis Prevention and Treatment. ( 26821915 )
2016
26
Interventions for the Management of Denture Stomatitis: A Systematic Review and Meta-Analysis. ( 27889906 )
2016
27
Antifungal Effect of Henna against Candida albicans Adhered to Acrylic Resin as a Possible Method for Prevention of Denture Stomatitis. ( 27223294 )
2016
28
Systemic T Cells and Monocyte Characteristics in Patients with Denture Stomatitis. ( 26883670 )
2016
29
Decreased production of proinflammatory cytokines by monocytes from individuals presenting Candida-associated denture stomatitis. ( 26587801 )
2016
30
Comments on &amp;quot;Methylene Blue-Mediated Photodynamic Inactivation Followed by Low-Laser Therapy versus Miconazole Gel in the Treatment of Denture Stomatitis&amp;quot;. ( 27754609 )
2016
31
Transcription Factors Efg1 and Bcr1 Regulate Biofilm Formation and Virulence during Candida albicans-Associated Denture Stomatitis. ( 27453977 )
2016
32
Production of virulence factors in Candida strains isolated from patients with denture stomatitis and control individuals. ( 26971635 )
2016
33
EVALUATION OF DENTURE-RELATED FACTORS PREDISPOSING TO DENTURE STOMATITIS IN A LEBANESE POPULATION. ( 27999492 )
2016
34
Denture Stomatitis and Candida Albicans in Iranian Population: A Systematic Review and Meta-Analysis. ( 27840842 )
2016
35
Clinical study on thermography, as modern investigation method for Candida-associated denture stomatitis. ( 27151707 )
2016
36
Sustained drug-delivery system: a promising therapy for denture stomatitis? ( 27812610 )
2016
37
Denture Stomatitis – A Clinical Update. ( 29148646 )
2016
38
The Beneficial Effect of Equisetum giganteum L. against Candida Biofilm Formation: New Approaches to Denture Stomatitis. ( 26290676 )
2015
39
Methylene Blue-Mediated Photodynamic Inactivation Followed by Low-Laser Therapy versus Miconazole Gel in the Treatment of Denture Stomatitis. ( 26375599 )
2015
40
Invitro Antifungal Evaluation of Denture Soft Liner Incorporated with Tea Tree Oil: A New Therapeutic Approach Towards Denture Stomatitis. ( 26266221 )
2015
41
Photodynamic inactivation of virulence factors of Candida strains isolated from patients with denture stomatitis. ( 26398815 )
2015
42
Expression of Secreted Aspartyl Proteinases in an Experimental Model of Candida albicans-Associated Denture Stomatitis. ( 25857681 )
2015
43
A case with tumor of left parotid gland and denture stomatitis. ( 25826511 )
2015
44
Uncaria tomentosa Gel against Denture Stomatitis: Clinical Report. ( 25675972 )
2015
45
Antifungal medications or disinfectants for denture stomatitis. ( 24971864 )
2014
46
Antifungal Activity of Apple Cider Vinegar on Candida Species Involved in Denture Stomatitis. ( 25219289 )
2014
47
Role of salivary and candidal proteins in denture stomatitis: an exploratory proteomic analysis. ( 24947908 )
2014
48
Is denture stomatitis always related with candida infection? A case control study. ( 25082257 )
2014
49
Evaluation of different treatment methods against denture stomatitis: a randomized clinical study. ( 24908596 )
2014
50
Use of Candida-specific chicken egg yolk antibodies to inhibit the adhering of Candida to denture base materials: prevention of denture stomatitis. ( 25393605 )
2014

Variations for Denture Stomatitis

Expression for Denture Stomatitis

Search GEO for disease gene expression data for Denture Stomatitis.

Pathways for Denture Stomatitis

Pathways related to Denture Stomatitis according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.03 CCL2 CXCL8 IL6
2
Show member pathways
11.77 CCL2 CXCL8 IL6
3 11.73 CCL2 CXCL8 IL6
4
Show member pathways
11.7 CCL2 CXCL8 CXCR1
5 11.67 CCL2 CXCL8 IL6
6 11.58 CCL2 CXCL8 IL6
7 11.5 CCL2 CXCL8 IL6
8 11.38 CXCL8 CXCR1
9
Show member pathways
11.33 CCL2 CXCL8
10 11.31 CXCL8 IL6
11 11.3 CXCL8 IL6
12 11.3 CCL2 CXCL8 IL6
13 11.23 CXCR1 IL6
14 11.21 CXCL8 IL6
15 11.14 CXCL8 CXCR1 IL6
16 11.02 CCL2 CXCL8 IL6
17 10.92 CCL2 CXCL8 IL6
18 10.82 CCL2 CXCL8 IL6
19 10.77 CXCL8 IL6
20 10.33 CCL2 CXCL8 IL6

GO Terms for Denture Stomatitis

Biological processes related to Denture Stomatitis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.63 CCL2 CXCL8 IL6
2 immune response GO:0006955 9.62 CCL2 CXCL8 CXCR1 IL6
3 chemotaxis GO:0006935 9.54 CCL2 CXCL8 CXCR1
4 humoral immune response GO:0006959 9.49 CCL2 IL6
5 monocyte chemotaxis GO:0002548 9.48 CCL2 IL6
6 receptor internalization GO:0031623 9.43 CXCL8 CXCR1
7 cellular response to fibroblast growth factor stimulus GO:0044344 9.4 CCL2 CXCL8
8 neutrophil chemotaxis GO:0030593 9.33 CCL2 CXCL8 CXCR1
9 PERK-mediated unfolded protein response GO:0036499 9.26 CCL2 CXCL8
10 chemokine-mediated signaling pathway GO:0070098 9.13 CCL2 CXCL8 CXCR1
11 cellular response to lipopolysaccharide GO:0071222 8.92 BCR CCL2 CXCL8 IL6

Molecular functions related to Denture Stomatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 8.96 CCL2 CXCL8
2 cytokine activity GO:0005125 8.8 CCL2 CXCL8 IL6

Sources for Denture Stomatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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