MCID: DNT008
MIFTS: 35

Denture Stomatitis

Categories: Oral diseases

Aliases & Classifications for Denture Stomatitis

MalaCards integrated aliases for Denture Stomatitis:

Name: Denture Stomatitis 12 15 17
Stomatitis, Denture 43 71
Denture Sore Mouth 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11875
MeSH 43 D013282
SNOMED-CT 67 69254008
ICD10 32 K12.1
UMLS 71 C0038364

Summaries for Denture Stomatitis

MalaCards based summary : Denture Stomatitis, also known as stomatitis, denture, is related to oral candidiasis and contact dermatitis. An important gene associated with Denture Stomatitis is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways/superpathways are IL-17 Family Signaling Pathways and Yersinia infection. The drugs Nystatin and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include colon, monocytes and bone.

Related Diseases for Denture Stomatitis

Diseases related to Denture Stomatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 151)
# Related Disease Score Top Affiliating Genes
1 oral candidiasis 30.7 DEFB4A CXCL8 CLEC7A
2 contact dermatitis 30.5 IL6 CXCL8 CCL2
3 candidiasis 30.0 IL6 DEFB4A CXCL8 CLEC7A CDR1
4 periodontitis 29.8 IL6 DEFB4A CXCL8 CCL2
5 gastritis 29.7 IL6 DEFB4A CXCL8
6 gingivitis 29.6 IL6 DEFB4A CXCL8 CCL2
7 stomatitis 11.3
8 idiopathic anterior uveitis 10.5 IL6 CXCL8
9 streptococcal toxic-shock syndrome 10.5 IL6 CXCL8
10 acute transverse myelitis 10.5 IL6 CXCL8
11 transverse myelitis 10.5 IL6 CXCL8
12 herpes simplex virus keratitis 10.5 CXCL8 CCL2
13 candida glabrata 10.4
14 post-cardiac arrest syndrome 10.4 IL6 CXCL8
15 stachybotrys chartarum 10.4 IL6 CCL2
16 recurrent corneal erosion 10.4 IL6 CXCL8
17 bone sarcoma 10.4 IL6 CXCL8
18 angular cheilitis 10.4
19 cheilitis 10.4
20 hard palate cancer 10.4
21 acute monoblastic leukemia 10.4 IL6 CXCL8
22 pyuria 10.4 IL6 CXCL8
23 mycetoma 10.4 CXCL8 CSN1S1
24 peptic esophagitis 10.4 IL6 CXCL8
25 anthracosis 10.4 IL6 CCL2
26 tuberculous meningitis 10.4 CXCL8 CCL2
27 chlamydia pneumonia 10.4 IL6 CXCL8
28 irritant dermatitis 10.4 IL6 CXCL8
29 fuchs' heterochromic uveitis 10.4 IL6 CXCL8 CCL2
30 haemophilus influenzae 10.4 CXCL8 CLEC7A
31 uveitis 10.4 IL6 CXCL8 CCL2
32 meningitis 10.3 IL6 CXCL8 CCL2
33 papillary conjunctivitis 10.3 IL6 CXCL8 CCL2
34 conjunctivitis 10.3 IL6 CXCL8 CCL2
35 viral pneumonia 10.3 IL6 CXCL8 CCL2
36 macular retinal edema 10.3 IL6 CXCL8 CCL2
37 vitreous disease 10.3 IL6 CXCL8 CCL2
38 relapsing polychondritis 10.3 IL6 CXCL8 CCL2
39 drug-induced lupus erythematosus 10.3 IL6 CXCL8 CCL2
40 radiculopathy 10.3 IL6 CXCL8 CCL2
41 bacteriuria 10.3 IL6 CXCL8 CCL2
42 viral meningitis 10.3 IL6 CXCL8 CCL2
43 periapical periodontitis 10.3 IL6 CXCL8
44 viral encephalitis 10.3 IL6 CXCL8 CCL2
45 leptospirosis 10.3 IL6 CXCL8 CCL2
46 cytomegalovirus infection 10.3 IL6 CXCL8 CCL2
47 complex regional pain syndrome 10.3 IL6 CXCL8 CCL2
48 leukemia, acute monocytic 10.3 IL6 CXCL8 CCL2
49 retinal vein occlusion 10.3 IL6 CXCL8 CCL2
50 acute cystitis 10.3 IL6 CXCL8 CCL2

Graphical network of the top 20 diseases related to Denture Stomatitis:



Diseases related to Denture Stomatitis

Symptoms & Phenotypes for Denture Stomatitis

Drugs & Therapeutics for Denture Stomatitis

Drugs for Denture Stomatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nystatin Approved, Vet_approved Phase 4 1400-61-9 11953884
2
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
3
Methylene blue Approved, Investigational Phase 4 61-73-4
4 Ionophores Phase 4
5 Antifungal Agents Phase 4
6 Pharmaceutical Solutions Phase 4
7 Propolis Phase 3
8 Cytochrome P-450 CYP3A Inhibitors Phase 3
9 Cytochrome P-450 Enzyme Inhibitors Phase 3
10 Hormone Antagonists Phase 3
11 Bee Products Phase 3
12 Anti-Infective Agents, Local Phase 3
13 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
14 Steroid Synthesis Inhibitors Phase 3
15 Hormones Phase 3
16
Clotrimazole Approved, Vet_approved Phase 2 23593-75-1 2812
17 Garlic Approved, Nutraceutical Phase 2
18
Mechlorethamine Approved, Investigational 51-75-2 4033
19
Sage Approved
20
Titanium dioxide Approved 13463-67-7
21
Pomegranate Experimental, Investigational
22 Chlorhexidine gluconate
23 Disinfectants
24 Sodium hypochlorite
25 Eusol
26 Alkylating Agents
27 chloramine-T
28 Anti-Inflammatory Agents
29 Anti-Infective Agents
30 Anti-Bacterial Agents
31 Dermatologic Agents
32 Protective Agents
33 Photosensitizing Agents
34 Radiation-Protective Agents
35 Sunscreening Agents

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 Photodynamic Therapy Against Candida Spp. in Complete Denture Wearers: a Randomized Clinical Trial Completed NCT02642900 Phase 4 Nystatin 100.000 units
2 Efficacy of Standardized-propolis Extract (EPP-AF®) Gel Formulation as Buccal Antiseptic in Elderly People Completed NCT02818803 Phase 3 Miconazole
3 Comparison of Therapeutic Effect of Aqueous Extract of Garlic and Nystatin Mouthwash in Denture Stomatitis Completed NCT01198223 Phase 2 garlic , nystatin
4 Efficacy of Slow Release Clotrimazole Varnish Treating Denture Stomatitis Completed NCT00835029 Phase 2 Clotrimazole varnish;Clotrimazole troches
5 The Surface Roughness of Rapid Heat Cured Acrylic Resin Versus Modified Conventional Acrylic Resin With Titanium Dioxide Nanoparticles in Maxillary Single Dentures: A Randomized Clinical Trials Unknown status NCT02950584 Phase 1
6 Phase-I Clinical Trial on the Effect of Palatal Brushing on Denture Stomatitis Completed NCT01643876 Phase 1
7 Effects of Denture-Related Stomatitis on Blood Pressure, Endothelial Function and Systemic Immune Response in Patients With Dentures Unknown status NCT02166450 Nystatin
8 Microbiological Comparative Study Between Single Maxillary Denture Fabricated From Rapid Heat Cured Resin and Conventional Acrylic Resin Modified by Titanium Dioxide Nanoparticles Unknown status NCT02950623
9 The Clinical Efficacy of Topical Nasal Pomegranate Fruit Extract (PFE) for Patients With Chronic Rhinitis, Chronic Sinusitis With or Without Nasal Polyps Unknown status NCT01564849
10 Improving Practice Guidelines for the Treatment of Denture-related Erythematous Stomatitis: A Pragmatic International Multicenter Randomized Controlled Trial Completed NCT02686632
11 Novel Coating to Minimize Bacterial Adhesions and Tooth Wear in Denture Acrylic Completed NCT02834832
12 Hygiene Protocols for Cleaning Complete Dentures Completed NCT01906242
13 A Randomized Trial of Experimental Dentifrices for Cleaning Dentures Completed NCT01237795
14 Efficacy of a Propolis Solution for Cleaning Complete Dentures: a Randomized Crossover Trial Completed NCT01237782 Denture soaking solution;Saline solution
15 Randomized Controlled Clinical Trial for Evaluating a Sage-based Mouthrinse in Regard to Its Anti-inflammatory Potential in Elderly Patients Which Are Dependent in Their ADLs Completed NCT02830802
16 ASSESSMENT OF THE IMPACT OF CLEANING METHODS AND OVERNIGHT DENTURE STORAGE ON BIOFILM FORMATION ON REMOVABLE ACRYLIC DENTURES. Completed NCT02454413
17 Anti-Microbial Effect of Titanium Dioxide Nano Particles Incorporated Acrylic Resin Denture Base Materials in Completely Edentulous Patients: A Randomized Controlled Trial Not yet recruiting NCT03666195

Search NIH Clinical Center for Denture Stomatitis

Cochrane evidence based reviews: stomatitis, denture

Genetic Tests for Denture Stomatitis

Anatomical Context for Denture Stomatitis

MalaCards organs/tissues related to Denture Stomatitis:

40
Colon, Monocytes, Bone, Testes, Endothelial, Salivary Gland, Neutrophil

Publications for Denture Stomatitis

Articles related to Denture Stomatitis:

(show top 50) (show all 701)
# Title Authors PMID Year
1
The Impact of Nicotine and Cigarette Smoke Condensate on Metabolic Activity and Biofilm Formation of Candida albicans on Acrylic Denture Material. 61
30028051 2020
2
Oral Candidiasis: A Disease of Opportunity. 61
31963180 2020
3
Activity of chitosan antifungal denture adhesive against common Candida species and Candida albicans adherence on denture base acrylic resin. 61
31813582 2020
4
The effects of three disinfection protocols on Candida spp., denture stomatitis, and biofilm: A parallel group randomized controlled trial. 61
31955835 2020
5
Self-perceived oral health among institutionalized older adults in Taubate, Brazil. 61
31912539 2020
6
Efficacy of a propolis solution for cleaning complete dentures. 61
31920057 2019
7
Digital Design of a Universal Rat Intraoral Device for Therapeutic Evaluation of a Topical Formulation against Candida-Associated Denture Stomatitis. 61
31527130 2019
8
Efficacy of photodynamic therapy versus local nystatin in the treatment of denture stomatitis: A randomized clinical study. 61
31454713 2019
9
Determination of the effects of cinnamon bark fractions on Candida albicans and oral epithelial cells. 61
31703673 2019
10
Impact of caffeine on metabolic activity and biofilm formation of Candida albicans on acrylic denture resin in the presence of nicotine. 61
31703923 2019
11
The effect of overnight storage conditions on complete denture colonization by Candida albicans and dimensional stability: A systematic review. 61
31787270 2019
12
Denture stomatitis associated with small-colony variants of Staphylococcus aureus: a case report. 61
31604449 2019
13
Salivary Biomarkers in Denture Stomatitis: A Systematic Review. 61
30931724 2019
14
Mechanical and Surface Properties of Resilient Denture Liners Modified with Chitosan Salts. 61
31717771 2019
15
Comparison of the efficacy of indocyanine green-mediated photodynamic therapy and nystatin therapy in treatment of denture stomatitis. 61
31185323 2019
16
Severity of Candida-associated denture stomatitis is improved in institutionalized elders who consume Lactobacillus rhamnosus SP1. 61
30963591 2019
17
Retrospective cohort analysis of maxillary overdentures retained by unsplinted implants. 61
30948296 2019
18
Nicotine Upregulates Coaggregation of Candida albicans and Streptococcus mutans. 61
28598524 2019
19
Candida albicans-Cell Interactions Activate Innate Immune Defense in Human Palate Epithelial Primary Cells via Nitric Oxide (NO) and β-Defensin 2 (hBD-2). 61
31336838 2019
20
Sensitivity to antifungals by Candida spp samples isolated from cases of chronic atrophic candidiasis (CAC). 61
31291399 2019
21
Molecular community profiling of the bacterial microbiota associated with denture-related stomatitis. 61
31308427 2019
22
Laboratory-Based Investigation of Denture Sonication Method in Patients with Candida-Associated Denture Stomatitis. 61
28872720 2019
23
Association between denture stomatitis, candida species and diabetic status. 61
31538448 2019
24
Effectiveness of an Alcohol-Free Chitosan-Curcuminoid Mouthwash Compared with Chlorhexidine Mouthwash in Denture Stomatitis Treatment: A Randomized Trial. 61
30758216 2019
25
Candida glabrata Has No Enhancing Role in the Pathogenesis of Candida-Associated Denture Stomatitis in a Rat Model. 61
30944214 2019
26
Modulation of Candida albicans virulence in in vitro biofilms by oral bacteria. 61
30825340 2019
27
Erythematous and Vascular Oral Mucosal Lesions: A Clinicopathologic Review of Red Entities. 61
30693460 2019
28
In-vitro antifungal efficacy of tissue conditioner-chitosan composites as potential treatment therapy for denture stomatitis. 61
30543887 2019
29
Differential Mucosal Gene Expression Patterns in Candida-Associated, Chronic Oral Denture Stomatitis. 61
30536831 2019
30
In vitro assessment of the antifungal effects of neem powder added to polymethyl methacrylate denture base material. 61
30805122 2019
31
Development and validation of mathematical models for testing antifungal activity of different essential oils against Candida species. 61
30530237 2019
32
In Vitro Evaluation of Adhesion of Candida albicans on CAD/CAM PMMA-Based Polymers. 61
29962017 2019
33
Anti-biofilm Action of Chenopodium ambrosioides Extract, Cytotoxic Potential and Effects on Acrylic Denture Surface. 61
31456753 2019
34
Evaluation of antibacterial and antifungal properties of a tissue conditioner used in complete dentures after incorporation of ZnO‒Ag nanoparticles. 61
31217913 2019
35
Decreasing Cell Population of Individual Candida Species Does Not Impair the Virulence of Candida albicans and Candida glabrata Mixed Biofilms. 61
31354684 2019
36
The effect of nanodiamonds on candida albicans adhesion and surface characteristics of PMMA denture base material - an in vitro study. 61
31691740 2019
37
In vivo biocompatibility of an interim denture resilient liner containing antifungal drugs. 61
30646999 2019
38
Candida-Bacterial Biofilms and Host-Microbe Interactions in Oral Diseases. 61
31732939 2019
39
Do raspberry extracts and fractions have antifungal or anti-adherent potential against Candida spp.? 61
30179710 2018
40
A critical review of protocols for conventional microwave oven use for denture disinfection. 61
30325592 2018
41
Role of laser or photodynamic therapy in treatment of denture stomatitis: A systematic review. 61
29807743 2018
42
Promise of Combining Antifungal Agents in Denture Adhesives to Fight Candida Species Infections. 61
27870138 2018
43
Efficacy of Camellia sinensis extract against Candida species in patients with denture stomatitis. 61
30619964 2018
44
Photodynamic inactivation in the expression of the Candida albicans genes ALS3, HWP1, BCR1, TEC1, CPH1, and EFG1 in biofilms. 61
29589176 2018
45
Evaluation of the effect of denture cleansers on the surface roughness of hard denture base material: An In vitro study. 61
30409949 2018
46
Epidemiology of oral mucosal lesions in Slovenia. 61
30210036 2018
47
Cytokine gene polymorphism in denture stomatitis patients: A clinical study. 61
29423993 2018
48
Sodium bicarbonate: A review and its uses in dentistry. 61
30409952 2018
49
Viability of Candida albicans in Denture Base Resin After Disinfection: A Preliminary Study. 61
30180227 2018
50
Antifungal and Mechanical Properties of Tissue Conditioner Containing Plant-Derived Component: An In Vitro Study. 61
28901663 2018

Variations for Denture Stomatitis

Expression for Denture Stomatitis

Search GEO for disease gene expression data for Denture Stomatitis.

Pathways for Denture Stomatitis

GO Terms for Denture Stomatitis

Biological processes related to Denture Stomatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.46 IL6 CXCL8 CLEC7A CCL2
2 PERK-mediated unfolded protein response GO:0036499 8.96 CXCL8 CCL2
3 cellular response to lipopolysaccharide GO:0071222 8.92 IL6 CXCL8 CCL2 BCR

Sources for Denture Stomatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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