MCID: DPR002
MIFTS: 41

Depersonalization Disorder

Categories: Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Depersonalization Disorder

MalaCards integrated aliases for Depersonalization Disorder:

Name: Depersonalization Disorder 12 74 20 15 71
Depersonalization 44 71
Depersonalization/derealization Disorder 20
Neurotic Derealization 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11038
ICD9CM 34 300.6
MeSH 44 D003861
NCIt 50 C94331
SNOMED-CT 67 70764005
ICD10 32 F48.1
UMLS 71 C0011551 C0683416

Summaries for Depersonalization Disorder

Disease Ontology : 12 A dissociative disorder in which the sufferer is affected by persistent or recurrent feelings of depersonalization and/or derealization.

MalaCards based summary : Depersonalization Disorder, also known as depersonalization, is related to schizophrenia and dissociative disorder, and has symptoms including symptoms, feeling detached and feeling strange. An important gene associated with Depersonalization Disorder is GLUD2 (Glutamate Dehydrogenase 2), and among its related pathways/superpathways are Peptide ligand-binding receptors and Circadian entrainment. The drugs Fluoxetine and Neurotransmitter Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and eye, and related phenotype is behavior/neurological.

Wikipedia : 74 Depersonalization-derealization disorder (DPDR, DPD) is a mental disorder in which the person has... more...

Related Diseases for Depersonalization Disorder

Diseases related to Depersonalization Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Related Disease Score Top Affiliating Genes
1 schizophrenia 27.9 PNOC GRIN3B GRIN3A GRIK4 GRIK3 GRID2
2 dissociative disorder 10.3
3 amnestic disorder 10.2
4 personality disorder 10.2
5 social phobia 10.2
6 temporal lobe epilepsy 10.2
7 anxiety 10.2
8 dissociative amnesia 10.2
9 obsessive-compulsive disorder 10.2
10 endogenous depression 10.1
11 acute stress disorder 10.1
12 major depressive disorder 10.1
13 alexithymia 10.1
14 avoidant personality disorder 10.1
15 mental depression 10.1
16 post-traumatic stress disorder 10.1
17 depression 10.1
18 major affective disorder 8 10.0
19 major affective disorder 9 10.0
20 bipolar disorder 10.0
21 agoraphobia 10.0
22 bipolar i disorder 9.9
23 focal epilepsy 9.9
24 melancholia 9.9
25 mood disorder 9.9
26 subacute delirium 9.9
27 koro 9.9
28 migraine with or without aura 1 9.9
29 exanthem 9.9
30 schizotypal personality disorder 9.9
31 borderline personality disorder 9.9
32 multiple personality disorder 9.9
33 neurotic disorder 9.9
34 panic disorder 9.9
35 severe combined immunodeficiency 9.9
36 major affective disorder 1 9.8
37 motion sickness 9.8
38 autism 9.8
39 intracranial hypertension, idiopathic 9.8
40 ataxia and polyneuropathy, adult-onset 9.8
41 yemenite deaf-blind hypopigmentation syndrome 9.8
42 anorexia nervosa 9.8
43 phobia, specific 9.8
44 aphasia 9.8
45 anosognosia 9.8
46 covid-19 9.8
47 schizophreniform disorder 9.8
48 allergic disease 9.8
49 dysthymic disorder 9.8
50 atypical depressive disorder 9.8

Graphical network of the top 20 diseases related to Depersonalization Disorder:



Diseases related to Depersonalization Disorder

Symptoms & Phenotypes for Depersonalization Disorder

UMLS symptoms related to Depersonalization Disorder:


symptoms, feeling detached, feeling strange, feeling weightless, floating feeling, affective symptoms, behavioral symptoms, schizophrenic language

MGI Mouse Phenotypes related to Depersonalization Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.17 GRID2 GRIK3 GRIK4 GRIN3A GRIN3B HAPLN1

Drugs & Therapeutics for Depersonalization Disorder

Drugs for Depersonalization Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluoxetine Approved, Vet_approved 54910-89-3 3386
2 Neurotransmitter Agents
3 Cytochrome P-450 Enzyme Inhibitors
4 Psychotropic Drugs
5 Antidepressive Agents
6 Serotonin Uptake Inhibitors
7
Serotonin Investigational, Nutraceutical 50-67-9 5202

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Depersonalization Disorder With Transcranial Magnetic Stimulation (TMS) Completed NCT00529217 Phase 2
2 Treatment of Depersonalization Disorder With Repetitive Transcranial Magnetic Stimulation (rTMS) Withdrawn NCT02256085 Phase 2
3 A Brief Cognitive Behavioural Therapy (CBT) Intervention for Depersonalisation/Derealisation in Psychosis: a Feasibility Study Completed NCT02427542 Phase 1
4 Depersonalization Disorder: Therapeutic Effect of Neuronavigated Repetitive Transcranial Stimulation of Right Angular Gyrus. Unknown status NCT02476435
5 Study of Fluoxetine in Patients With Depersonalization Disorder Completed NCT00004446 fluoxetine
6 Body Image and Self-esteem in a Sample of Oncological Adolescents: A Pilot Study Recruiting NCT04043117
7 Metacognitive Training Program With Depression Terminated NCT02415426

Search NIH Clinical Center for Depersonalization Disorder

Cochrane evidence based reviews: depersonalization

Genetic Tests for Depersonalization Disorder

Anatomical Context for Depersonalization Disorder

MalaCards organs/tissues related to Depersonalization Disorder:

40
Brain, Temporal Lobe, Eye, Bone Marrow, Cortex, Spinal Cord, Skin

Publications for Depersonalization Disorder

Articles related to Depersonalization Disorder:

(show top 50) (show all 2653)
# Title Authors PMID Year
1
Enhanced Stress Resilience Training in Surgeons: Iterative Adaptation and Biopsychosocial Effects in 2 Small Randomized Trials. 61
32773637 2021
2
Burnout Syndrome in Paediatric Nurses: A Multi-Centre Study. 61
33535707 2021
3
Prevalence of Burnout Syndrome for Public Schoolteachers in the Brazilian Context: A Systematic Review. 61
33567788 2021
4
Understanding the Links between Inferring Mental States, Empathy, and Burnout in Medical Contexts. 61
33546199 2021
5
Do informal caregivers experience more burnout? A meta-analytic study. 61
32816530 2021
6
Syndrome of professional wear and tear or «burnout» in Andalusian ophthalmology. 61
33268284 2021
7
Professional Burnout Survey for Practicing Female Pelvic Medicine and Reconstructive Surgeons: A Cross-sectional Study. 61
32740467 2021
8
Prevalence of burnout and its relationship to health status and social support in more than 1000 subspecialty anesthesiologists. 61
33574158 2021
9
Well-being in Residency: Impact of an Online Physician Well-being Course on Resiliency and Burnout in Incoming Residents. 61
33566347 2021
10
[Psychological flexibility, burnout and job satisfaction in dementia care workers]. 61
33608164 2021
11
The burden of care and burn out syndrome in caregivers of an Egyptian sample of schizophrenia patients. 61
33567951 2021
12
Physician Task Load and the Risk of Burnout Among US Physicians in a National Survey. 61
33168367 2021
13
Supporting Caregivers During COVID-19: Transforming Compassionate Care From a Way of Doing to Being. 61
33543706 2021
14
Posttraumatic cognitions predict distorted body perceptions in women with dissociative identity disorder. 61
33388699 2021
15
A simple screening tool for occupational burnout among dentists. 61
33494868 2021
16
How Do Areas of Work Life Drive Burnout in Orthopaedic Attending Surgeons, Fellows, and Residents? 61
32858718 2021
17
[Analysis on job burnout status and its influencing factors among female workers of labor-intensive enterprises]. 61
33535332 2021
18
Prevalence of Burnout Among Cardiothoracic Radiologists. 61
32555005 2021
19
Intensive care nurse staffing and nurse outcomes: A systematic review. 61
33403791 2021
20
Prevalence and associated factors for burnout among attending general surgeons: a national cross-sectional survey. 61
33413318 2021
21
Drivers of distress and well-being amongst pediatric surgeons. 61
33487463 2021
22
Empowering qualities and skills for leaders in neurosurgery. 61
33500824 2021
23
Burnout in oncology: Magnitude, risk factors and screening among professionals from Middle East and North Africa (BOMENA study). 61
33427352 2021
24
Sensory Processing Sensitivity and Compassion Satisfaction as Risk/Protective Factors from Burnout and Compassion Fatigue in Healthcare and Education Professionals. 61
33445789 2021
25
Trauma and Coping Strategies in Police Officers: A Quantitative-Qualitative Pilot Study. 61
33499414 2021
26
[Current and future strategies for burnout in Japanese neurologists]. 61
33504753 2021
27
The Role of Personal Accomplishment in General Surgery Resident Wellbeing. 61
33491973 2021
28
Residents' Perceptions of Faculty Behaviors and Resident Burnout: a Cross-Sectional Survey Study Across a Large Health Care Organization. 61
33483819 2021
29
[Burnout Among Physicians Working in Psychiatric and Psychosomatic Care]. 61
33472266 2021
30
Value Conflict, Lack of Rewards, and Sense of Community as Psychosocial Risk Factors of Burnout in Communication Professionals (Press, Radio, and Television). 61
33418874 2021
31
Mindful Ethical Practice and Resilience Academy: Equipping Nurses to Address Ethical Challenges. 61
33385208 2021
32
Assessment of burnout among postgraduate pharmacy residents: A pilot study. 61
33131616 2021
33
Prevalence of burnout syndrome among Italian volunteers of the Red Cross: a cross-sectional study. 61
33473066 2021
34
Reduced recognition of facial emotional expressions in global burnout and burnout depersonalization in healthcare providers. 61
33520445 2021
35
Split-mirror gazing increases dissociative states and illusions of self-identity. 61
33470913 2021
36
Occupational burnout among active physiotherapists working in clinical hospitals during the COVID-19 pandemic in south-eastern Poland. 61
33492259 2021
37
Secondary Traumatic Stress and Burnout in Healthcare Workers during COVID-19 Outbreak. 61
33466346 2021
38
Childhood abuse experiences, depression and dissociation symptoms in relation to suicide attempts and suicidal ideation. 61
33427600 2021
39
Validating Dissociative Experience Scale (DES) in a Greek sample. 61
33427597 2021
40
Anxiety in Residents in China: Prevalence and Risk Factors in a Multicenter Study. 61
33464742 2021
41
Burnout and Anxiety Among Trauma Nursing Specialties in a Rural Level I Trauma Center. 61
33417400 2021
42
Collegial surface acting emotional labour, burnout and intention to leave in novice and pre-retirement nurses in the United Kingdom: A cross-sectional study. 61
33318854 2021
43
Prevalence, Related Factors, and Levels of Burnout Among Midwives: A Systematic Review. 61
33463008 2021
44
Personal and Work-Related Factors Associated with Good Care for Institutionalized Older Adults. 61
33477928 2021
45
Mindfulness Workshops Effects on Nurses' Burnout, Stress, and Mindfulness Skills. 61
32282563 2021
46
Addressing Physician Burnout and Ensuring High-Quality Care of the Physician Workforce. 61
33278277 2021
47
Burnout Among Urologists from Denmark and Michigan. 61
32916191 2021
48
Does burnout affect clinical reasoning? An observational study among residents in general practice. 61
33413369 2021
49
Factors associated with self-reported burnout level in allied healthcare professionals in a tertiary hospital in Singapore. 61
33406132 2021
50
High levels of burnout and depression in a population of senior dental students in a school of dentistry in Korea. 61
33384780 2021

Variations for Depersonalization Disorder

Expression for Depersonalization Disorder

Search GEO for disease gene expression data for Depersonalization Disorder.

Pathways for Depersonalization Disorder

GO Terms for Depersonalization Disorder

Cellular components related to Depersonalization Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell junction GO:0030054 9.72 GRIN3B GRIN3A GRIK4 GRIK3 GRID2
2 neuronal cell body GO:0043025 9.61 PNOC GRIN3B GRIN3A
3 glutamatergic synapse GO:0098978 9.54 GRIN3A GRIK3 GRID2
4 presynaptic membrane GO:0042734 9.4 GRIK4 GRIK3
5 postsynaptic membrane GO:0045211 9.35 GRIN3B GRIN3A GRIK4 GRIK3 GRID2
6 NMDA selective glutamate receptor complex GO:0017146 9.26 GRIN3B GRIN3A
7 synapse GO:0045202 9.17 PNOC HAPLN1 GRIN3B GRIN3A GRIK4 GRIK3
8 kainate selective glutamate receptor complex GO:0032983 9.16 GRIK4 GRIK3

Biological processes related to Depersonalization Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.77 GRIN3B GRIN3A GRIK4 GRIK3 GRID2
2 modulation of chemical synaptic transmission GO:0050804 9.58 GRIK4 GRIK3 GRID2
3 ion transmembrane transport GO:0034220 9.55 GRIN3B GRIN3A GRIK4 GRIK3 GRID2
4 regulation of postsynaptic membrane potential GO:0060078 9.5 GRIN3A GRIK4 GRIK3
5 prepulse inhibition GO:0060134 9.43 GRIN3A GRID2
6 synaptic transmission, glutamatergic GO:0035249 9.43 GRIK4 GRIK3 GRID2
7 glutamate receptor signaling pathway GO:0007215 9.13 GRIK4 GRIK3 GRID2
8 ionotropic glutamate receptor signaling pathway GO:0035235 9.02 GRIN3B GRIN3A GRIK4 GRIK3 GRID2

Molecular functions related to Depersonalization Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 9.72 GRIN3B GRIN3A GRIK4 GRIK3 GRID2
2 ion channel activity GO:0005216 9.65 GRIN3B GRIN3A GRIK4 GRIK3 GRID2
3 glutamate receptor activity GO:0008066 9.54 GRIK4 GRIK3 GRID2
4 calcium channel activity GO:0005262 9.48 GRIN3B GRIN3A
5 glycine binding GO:0016594 9.46 GRIN3B GRIN3A
6 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential GO:1904315 9.46 GRIN3A GRIK4 GRIK3 GRID2
7 NMDA glutamate receptor activity GO:0004972 9.43 GRIN3B GRIN3A
8 kainate selective glutamate receptor activity GO:0015277 9.4 GRIK4 GRIK3
9 ligand-gated ion channel activity GO:0015276 9.35 GRIN3B GRIN3A GRIK4 GRIK3 GRID2
10 ionotropic glutamate receptor activity GO:0004970 9.02 GRIN3B GRIN3A GRIK4 GRIK3 GRID2

Sources for Depersonalization Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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