MCID: DPR002
MIFTS: 40

Depersonalization Disorder

Categories: Eye diseases, Mental diseases, Neuronal diseases

Aliases & Classifications for Depersonalization Disorder

MalaCards integrated aliases for Depersonalization Disorder:

Name: Depersonalization Disorder 12 77 15 74
Depersonalization 45 74
Neurotic Derealization 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11038
ICD9CM 36 300.6
MeSH 45 D003861
NCIt 51 C94331
SNOMED-CT 69 70764005

Summaries for Depersonalization Disorder

Disease Ontology : 12 A dissociative disorder in which the sufferer is affected by persistent or recurrent feelings of depersonalization and/or derealization.

MalaCards based summary : Depersonalization Disorder, also known as depersonalization, is related to depersonalization/derealization disorder and dissociative disorder, and has symptoms including symptoms, feeling detached and feeling strange. An important gene associated with Depersonalization Disorder is TNFSF11 (TNF Superfamily Member 11), and among its related pathways/superpathways are NF-kappaB Signaling and Apoptosis and Autophagy. The drugs Fluoxetine and Psychotropic Drugs have been mentioned in the context of this disorder. Affiliated tissues include eye, temporal lobe and cortex.

Wikipedia : 77 Depersonalization disorder (DPD), also known as depersonalization/derealization disorder (DPDR), is a... more...

Related Diseases for Depersonalization Disorder

Diseases related to Depersonalization Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 28)
# Related Disease Score Top Affiliating Genes
1 depersonalization/derealization disorder 11.8
2 dissociative disorder 11.5
3 panic disorder 10.3
4 epilepsy 10.3
5 temporal lobe epilepsy 10.2
6 schizophrenia 10.1
7 alexithymia 10.1
8 depression 10.1
9 bipolar disorder 10.1
10 koro 10.1
11 obsessive-compulsive disorder 10.0
12 anxiety 10.0
13 neurotic disorder 10.0
14 multiple sclerosis 9.9
15 meniere disease 9.9
16 autism 9.9
17 borderline personality disorder 9.9
18 social phobia 9.9
19 allergic hypersensitivity disease 9.9
20 hypochondriasis 9.9
21 personality disorder 9.9
22 impotence 9.9
23 focal epilepsy 9.9
24 complex regional pain syndrome 9.9
25 agoraphobia 9.9
26 decubitus ulcer 9.9
27 cannabis abuse 9.9
28 headache 9.9

Graphical network of the top 20 diseases related to Depersonalization Disorder:



Diseases related to Depersonalization Disorder

Symptoms & Phenotypes for Depersonalization Disorder

UMLS symptoms related to Depersonalization Disorder:


symptoms, feeling detached, feeling strange, feeling weightless, floating feeling, affective symptoms, behavioral symptoms, schizophrenic language

Drugs & Therapeutics for Depersonalization Disorder

Drugs for Depersonalization Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluoxetine Approved, Vet_approved Not Applicable 54910-89-3 3386
2 Psychotropic Drugs Not Applicable
3 Serotonin Agents Not Applicable
4 Cytochrome P-450 Enzyme Inhibitors Not Applicable
5 Antidepressive Agents, Second-Generation Not Applicable
6 Serotonin Uptake Inhibitors Not Applicable
7 Cytochrome P-450 CYP2D6 Inhibitors Not Applicable
8 Antidepressive Agents Not Applicable
9 Neurotransmitter Agents Not Applicable
10 Neurotransmitter Uptake Inhibitors Not Applicable
11
Serotonin Investigational, Nutraceutical Not Applicable 50-67-9 5202

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Depersonalization Disorder With Transcranial Magnetic Stimulation (TMS) Completed NCT00529217 Phase 2
2 Treatment of Depersonalization Disorder With Repetitive Transcranial Magnetic Stimulation (rTMS) Withdrawn NCT02256085 Phase 2
3 Study of Fluoxetine in Patients With Depersonalization Disorder Completed NCT00004446 Not Applicable fluoxetine
4 Depersonalization Disorder: Therapeutic Effect of Neuronavigated Repetitive Transcranial Stimulation Recruiting NCT02476435 Not Applicable

Search NIH Clinical Center for Depersonalization Disorder

Cochrane evidence based reviews: depersonalization

Genetic Tests for Depersonalization Disorder

Anatomical Context for Depersonalization Disorder

MalaCards organs/tissues related to Depersonalization Disorder:

42
Eye, Temporal Lobe, Cortex, Testes, Brain, Heart, Prefrontal Cortex

Publications for Depersonalization Disorder

Articles related to Depersonalization Disorder:

(show top 50) (show all 345)
# Title Authors Year
1
Functional Connectivity Between Extrastriate Body Area and Default Mode Network Predicts Depersonalization Symptoms in Major Depression: Findings From an A Priori Specified Multinetwork Comparison. ( 31103548 )
2019
2
High Betrayal Adolescent Sexual Abuse and Nonsuicidal Self-Injury: The Role of Depersonalization in Emerging Adults. ( 30403925 )
2019
3
Minocycline-induced transient depersonalization: A case report. ( 30719316 )
2019
4
Influence of Visual and Vestibular Hypersensitivity on Derealization and Depersonalization in Chronic Dizziness. ( 30814972 )
2019
5
Strange-face illusions during eye-to-eye gazing in dyads: specific effects on derealization, depersonalization and dissociative identity. ( 30938658 )
2019
6
Anomalous Self-Experiences: Markers of Schizophrenia Vulnerability or Symptoms of Depersonalization Disorder? A Phenomenological Investigation of Two Cases. ( 29730662 )
2018
7
White matter network alterations in patients with depersonalization/derealization disorder. ( 29877178 )
2018
8
White matter network alterations in patients with depersonalization/derealization disorder. ( 30125247 )
2018
9
Depersonalization, adversity, emotionality, and coping with stressful situations. ( 28509616 )
2018
10
What was once essential, may become detrimental: The mediating role of depersonalization in the relationship between childhood emotional maltreatment and psychological distress in adults. ( 29144883 )
2018
11
Emotion regulation strategies moderate the relationship of fatigue with depersonalization and derealization symptoms. ( 29172049 )
2018
12
Resting-State Networks of Adolescents Experiencing Depersonalization-Like Illusions: Cross-sectional and Longitudinal Findings. ( 29566227 )
2018
13
Resolution of Acute-Onset Depersonalization/Derealization With Clonazepam and Inpatient Hospitalization. ( 29601318 )
2018
14
The depersonalized brain: New evidence supporting a distinction between depersonalization and derealization from discrete patterns of autonomic suppression observed in a non-clinical sample. ( 29929064 )
2018
15
Depersonalization Under Academic Stress: Frequency, Predictors, and Consequences. ( 29945133 )
2018
16
Third-Year Medical Students' Reactions to Surgical Patients in Pain: Doubt, Distress, and Depersonalization. ( 30144537 )
2018
17
Depersonalization and derealization in self-report and clinical interview: The spectrum of borderline personality disorder, dissociative disorders, and healthy controls. ( 27681414 )
2017
18
Association of Neglect-Like Symptoms with Anxiety, Somatization, and Depersonalization in Complex Regional Pain Syndrome. ( 27605590 )
2017
19
Treatment of Depersonalization Disorder With Repetitive Transcranial Magnetic Stimulation. ( 28291040 )
2017
20
Treatment of a Patient With Depersonalization Disorder With Low Frequency Repetitive Transcranial Magnetic Stimulation of the Right Temporo-Parietal Junction in a Private Practice Setting. ( 28291041 )
2017
21
Dual role as a protective factor for burnout-related depersonalization in oncologists. ( 28317213 )
2017
22
Daily Elevations in Dissociative Absorption and Depersonalization in a Nonclinical Sample Are Related to Daily Stress and Psychopathological Symptoms. ( 29087250 )
2017
23
The Dissociative Subtype of Posttraumatic Stress Disorder (PTSD) Among Adolescents: Co-Occurring PTSD, Depersonalization/Derealization, and Other Dissociation Symptoms. ( 29173740 )
2017
24
Ventrolateral prefrontal cortex repetitive transcranial magnetic stimulation in the treatment of depersonalization disorder: A consecutive case series. ( 27104926 )
2016
25
Emotional Experience and Awareness of Self: Functional MRI Studies of Depersonalization Disorder. ( 27313548 )
2016
26
Persistent Depersonalization/Derealization Disorder Induced by Synthetic Cannabinoids. ( 27477142 )
2016
27
Dissociable brain correlates for depression, anxiety, dissociation, and somatization in depersonalization-derealization disorder. ( 24059962 )
2016
28
Cognitive load and autonomic response patterns under negative priming demand in depersonalization-derealization disorder. ( 26791018 )
2016
29
Cardiac modulation of startle is altered in depersonalization-/derealization disorder: Evidence for impaired brainstem representation of baro-afferent neural traffic. ( 27078753 )
2016
30
Pain and tactile dissociation, derealization and depersonalization symptoms in women and recalled traumatic events in childhood, adolescence and early adulthood. ( 27086330 )
2016
31
Differential Diagnosis of an Elderly Manic-Depressive Patient with Depersonalization and Other Symptoms. ( 27293942 )
2016
32
A case series of 223 patients with depersonalization-derealization syndrome. ( 27349226 )
2016
33
The relationship of depersonalization and absorption to hallucinations in psychotic and non-clinical participants. ( 27525824 )
2016
34
Tracking Potentiating States of Dissociation: An Intensive Clinical Case Study of Sleep, Daydreaming, Mood, and Depersonalization/Derealization. ( 27582722 )
2016
35
Reduction of depersonalization during social stress through cognitive therapy for social anxiety disorder: A randomized controlled trial. ( 27648752 )
2016
36
Older women deserve more than chaos and depersonalization. ( 27814134 )
2016
37
RELIABILITY, VALIDITY, AND PSYCHOMETRIC PROPERTIES OF THE GREEK TRANSLATION OF THE CAMBRIDGE DEPERSONALIZATION SCALE (CDS). ( 27999491 )
2016
38
Grey matter alterations in patients with depersonalization disorder: a voxel-based morphometry study. ( 25285875 )
2015
39
Depersonalization/derealization disorder after exposure to mefloquine. ( 25619678 )
2015
40
Abnormal cardiovascular sympathetic and parasympathetic responses to physical and emotional stimuli in depersonalization disorder. ( 25859177 )
2015
41
Altered patterns of heartbeat-evoked potentials in depersonalization/derealization disorder: neurophysiological evidence for impaired cortical representation of bodily signals. ( 25984819 )
2015
42
Prevalence and correlates of depersonalization in students aged 12-18 years in Germany. ( 25201182 )
2015
43
Symptom profiles in depersonalization and anxiety disorders: an analysis of the Beck Anxiety Inventory. ( 25401973 )
2015
44
Organic depersonalization as a chronic sequela of mefloquine intoxication. ( 25619679 )
2015
45
Depersonalization: physiological or pathological in adolescents? ( 25748214 )
2015
46
Depersonalization: An exploratory factor analysis of the Italian version of the Cambridge Depersonalization Scale. ( 25863646 )
2015
47
The Occurrence of Depersonalization Symptoms After Accelerated HF-rTMS of the Left DLPFC in a Patient With Treatment-resistant Depression: A Case Report. ( 25865771 )
2015
48
"I HEAR MY VOICE, BUT WHO IS TALKING?": UNDERSTANDING DEPERSONALIZATION. ( 26443948 )
2015
49
A disembodied man: A case of somatopsychic depersonalization in schizotypal disorder. ( 26571072 )
2015
50
Vestibular Function and Depersonalization/Derealization Symptoms. ( 26595960 )
2015

Variations for Depersonalization Disorder

Expression for Depersonalization Disorder

Search GEO for disease gene expression data for Depersonalization Disorder.

Pathways for Depersonalization Disorder

Pathways related to Depersonalization Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.67 BCL10 TNFSF11
2 11.22 BCL10 TNFSF11
3 10.62 BCL10 TNFSF11

GO Terms for Depersonalization Disorder

Cellular components related to Depersonalization Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 8.62 BCL10 RAP1B

Biological processes related to Depersonalization Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homooligomerization GO:0051260 9.32 BCL10 TNFSF11
2 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.26 BCL10 TNFSF11
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.16 BCL10 TNFSF11
4 positive regulation of phosphorylation GO:0042327 8.96 BCL10 TNFSF11
5 positive regulation of T cell activation GO:0050870 8.62 BCL10 TNFSF11

Sources for Depersonalization Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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