MCID: DPR002
MIFTS: 43

Depersonalization Disorder

Categories: Eye diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Depersonalization Disorder

MalaCards integrated aliases for Depersonalization Disorder:

Name: Depersonalization Disorder 12 74 52 15 71
Depersonalization 43 71
Depersonalization/derealization Disorder 52
Neurotic Derealization 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11038
ICD9CM 34 300.6
MeSH 43 D003861
NCIt 49 C94331
SNOMED-CT 67 70764005
ICD10 32 F48.1
UMLS 71 C0011551 C0683416

Summaries for Depersonalization Disorder

Disease Ontology : 12 A dissociative disorder in which the sufferer is affected by persistent or recurrent feelings of depersonalization and/or derealization.

MalaCards based summary : Depersonalization Disorder, also known as depersonalization, is related to dissociative disorder and dissociative amnesia, and has symptoms including symptoms, feeling detached and feeling strange. An important gene associated with Depersonalization Disorder is TNFSF11 (TNF Superfamily Member 11), and among its related pathways/superpathways are Peptide ligand-binding receptors and Circadian entrainment. The drugs Etomidate and Ketamine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and temporal lobe.

Wikipedia : 74 Depersonalization disorder (DPD), also known as depersonalization/derealization disorder (DPDR), is a... more...

Related Diseases for Depersonalization Disorder

Diseases related to Depersonalization Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Related Disease Score Top Affiliating Genes
1 dissociative disorder 30.5 TNFSF11 DMTN
2 dissociative amnesia 10.4
3 anxiety 10.4
4 social phobia 10.3
5 temporal lobe epilepsy 10.3
6 amnestic disorder 10.3
7 personality disorder 10.3
8 endogenous depression 10.2
9 obsessive-compulsive disorder 10.2
10 schizophrenia 10.2
11 depression 10.2
12 major affective disorder 8 10.2
13 major affective disorder 9 10.2
14 epilepsy 10.2
15 bipolar disorder 10.2
16 agoraphobia 10.2
17 acute stress disorder 10.2
18 major depressive disorder 10.1
19 alexithymia 10.1
20 avoidant personality disorder 10.1
21 mental depression 10.1
22 bipolar i disorder 10.1
23 post-traumatic stress disorder 10.1
24 focal epilepsy 10.1
25 melancholia 10.1
26 mood disorder 10.1
27 subacute delirium 10.1
28 koro 10.1
29 encephalopathy 10.1
30 migraine with or without aura 1 10.0
31 exanthem 10.0
32 schizotypal personality disorder 10.0
33 borderline personality disorder 10.0
34 multiple personality disorder 10.0
35 neurotic disorder 10.0
36 panic disorder 10.0
37 severe combined immunodeficiency 10.0
38 neurofibromatosis, type ii 9.9
39 multiple sclerosis 9.9
40 motion sickness 9.9
41 autism 9.9
42 intracranial hypertension, idiopathic 9.9
43 ataxia and polyneuropathy, adult-onset 9.9
44 yemenite deaf-blind hypopigmentation syndrome 9.9
45 anorexia nervosa 9.9
46 phobia, specific 9.9
47 retinal dystrophy, iris coloboma, and comedogenic acne syndrome 9.9
48 aphasia 9.9
49 anosognosia 9.9
50 pain agnosia 9.9

Graphical network of the top 20 diseases related to Depersonalization Disorder:



Diseases related to Depersonalization Disorder

Symptoms & Phenotypes for Depersonalization Disorder

UMLS symptoms related to Depersonalization Disorder:


symptoms, feeling detached, feeling strange, feeling weightless, floating feeling, affective symptoms, behavioral symptoms, schizophrenic language

Drugs & Therapeutics for Depersonalization Disorder

Drugs for Depersonalization Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etomidate Approved Phase 4 33125-97-2 36339 667484
2
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
3
Cefpirome Approved Phase 4 84957-29-9 5479539
4
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
5
Sotalol Approved Phase 4 3930-20-9, 959-24-0 5253
6 Excitatory Amino Acid Antagonists Phase 4
7 Hypnotics and Sedatives Phase 4
8 Anesthetics, General Phase 4
9 Analgesics Phase 4
10 Anesthetics, Dissociative Phase 4
11 Anesthetics, Intravenous Phase 4
12 Anti-Infective Agents Phase 4
13 Anti-Bacterial Agents Phase 4
14 Norgestimate, ethinyl estradiol drug combination Phase 4
15 Antibiotics, Antitubercular Phase 4
16 Neurotransmitter Agents Phase 4
17 Sodium Channel Blockers Phase 4
18 Adrenergic Agents Phase 4
19 Adrenergic Antagonists Phase 4
20 Sympatholytics Phase 4
21 Anti-Arrhythmia Agents Phase 4
22 Adrenergic beta-Antagonists Phase 4
23 Diuretics, Potassium Sparing Phase 4
24 Pharmaceutical Solutions Phase 3
25 Micronutrients Phase 3
26 Trace Elements Phase 3
27
Fluoxetine Approved, Vet_approved 54910-89-3 3386
28
Mannitol Approved, Investigational Early Phase 1 69-65-8 6251 453
29
Metronidazole Approved 443-48-1 4173
30
Ketanserin Investigational Early Phase 1 74050-98-9 3822
31 Antidepressive Agents
32 Cytochrome P-450 Enzyme Inhibitors
33 Serotonin Uptake Inhibitors
34 Psychotropic Drugs
35 Serotonin Receptor Agonists Early Phase 1
36 Hallucinogens Early Phase 1
37 Anesthetics
38
Serotonin Investigational, Nutraceutical 50-67-9 5202

Interventional clinical trials:

(show all 33)
# Name Status NCT ID Phase Drugs
1 Ketamine Versus Etomidate During Rapid Sequence Intubation: Consequences on Hospital Morbidity Completed NCT00440102 Phase 4 Ketamine;Etomidate
2 Plasma and Abscess Fluid Pharmacokinetics of Cefpirome and Moxifloxacin After Single and Multiple Dose Administration Completed NCT00280514 Phase 4 cefpirome and moxifloxacin administration
3 A Prospective, Multi-Center, Randomized, Open Label Trial to Determine if a Common Atrial Fibrillation Risk Locus Modulates Differential Response to Antiarrhythmic Drugs Not yet recruiting NCT02347111 Phase 4 Flecainide;Sotalol
4 The Efficacy of Eye Movement Desensitization and Reprocessing (EMDR) in Patients With Post Traumatic Stress Disorder in Multiple Sclerosis. A Randomized Controlled Trial. Unknown status NCT01743664 Phase 3
5 Impact of a Specific Amino Acid Composition With Micronutrients on Wellbeing and Endocrine-cardiometabolic Situation of Patients With Chronic Exhaustion Conditions, Such as Burnout Completed NCT02997137 Phase 3
6 Treatment of Depersonalization Disorder With Transcranial Magnetic Stimulation (TMS) Completed NCT00529217 Phase 2
7 Alternative Treatments to Help Post Traumatic Stress Disorder Recruiting NCT03534583 Phase 2
8 Treatment of Depersonalization Disorder With Repetitive Transcranial Magnetic Stimulation (rTMS) Withdrawn NCT02256085 Phase 2
9 A Brief Cognitive Behavioural Therapy (CBT) Intervention for Depersonalisation/Derealisation in Psychosis: a Feasibility Study Completed NCT02427542 Phase 1
10 Depersonalization Disorder: Therapeutic Effect of Neuronavigated Repetitive Transcranial Stimulation of Right Angular Gyrus. Unknown status NCT02476435
11 The Reflect, Empathize, Analyze, and Discuss in Small Groups Study: The Effect of Peer-facilitated Small Group Discussions on Burnout and Professional Development Among Physician Trainees Unknown status NCT03163251
12 The Experience of Loneliness Among Ear, Nose and Throat (ENT) Surgical Patients During the Perioperative Period Unknown status NCT01203761
13 Study of Fluoxetine in Patients With Depersonalization Disorder Completed NCT00004446 fluoxetine
14 Burnout Syndrome Among Medical Residents Completed NCT03668080
15 Burn Out Among Surgical Residents Working at All Institutes in Lahore: An Area of Grave Concerns Completed NCT02206139
16 Burn Out Among Surgical Residents Working at Government Institutes in Lahore: An Area of Grave Concerns Completed NCT02204592
17 Effect of Video-Module Based Mindfulness Training on Physician Stress and Well Being Completed NCT02173626
18 Effectiveness of a Mind-body Stress Reduction Program for Nurses: A Randomized Controlled Study Completed NCT01796054
19 Role of the Serotonin 5-HT2A Receptor in LSD-induced Altered States of Consciousness (LDR-Study) Completed NCT03321136 Early Phase 1 LSD;LSD;LSD;LSD;LSD;Placebo
20 Can a Mindfulness Curriculum Prevent Burnout During Pediatric Internship? A Multi-center Cluster Randomized Controlled Trial. Completed NCT03148626
21 Individual Early Warning Score (I-EWS) - Does Clinical Assessment Improve Detection of Acute Deterioration in Hospitalized Patients - a Cluster-randomized Trial Completed NCT03690128
22 Achieving the Quadruple Aim by Reducing Burnout: A Randomized Trial of a Compassion Based Curriculum for Outpatient Teams Completed NCT03746574
23 Wellness and Distress in Health Care Professionals Dealing With End of Life and Bioethical Issues (WeDistressHELL) Completed NCT04434755
24 Sudarshan Kriya Yoga (SKY) in Post Traumatic Stress Disorder: a Feasibility Study Completed NCT02749253
25 Efficacy of Mindfulness-based Therapy vs. Relaxation in Prevention of Burnout in Medical Students : A Multicenter, Single Blind Randomized Controlled Study Recruiting NCT04026594
26 Body Image and Self-esteem in a Sample of Oncological Adolescents: A Pilot Study Recruiting NCT04043117
27 Enhanced Stress Resilience Training for Faculty Physicians Active, not recruiting NCT03516877
28 The Impact of Combined Mindfulness-Based Interventions and Nutritional Counseling on Physician Burnout: A Clinical Trial Active, not recruiting NCT04336436
29 Remote Physiologic Monitoring of Resident Wellness and Burnout Not yet recruiting NCT04304703
30 Anxiety Reduction Treatment for Acute Trauma Terminated NCT02315378
31 Wearable Brain Computer Interface (BCI) to Assist Communication in Mechanically Ventilated Patients the Intensive Care Unit (ICU) Terminated NCT02791425
32 Sudarshan Kriya Yoga (SKY) Versus Wait List Control (WLC) in Post Traumatic Stress Disorder: A Randomised Controlled Study Withdrawn NCT02553252
33 The Impact of Work Burnout on Sleep Quality and Negative Emotions in Medical Residents: An Intervention for Improving Wellbeing in Graduate Medical Education Withdrawn NCT02736045

Search NIH Clinical Center for Depersonalization Disorder

Cochrane evidence based reviews: depersonalization

Genetic Tests for Depersonalization Disorder

Anatomical Context for Depersonalization Disorder

MalaCards organs/tissues related to Depersonalization Disorder:

40
Brain, Testes, Temporal Lobe, Eye, Heart, Bone Marrow, Bone

Publications for Depersonalization Disorder

Articles related to Depersonalization Disorder:

(show top 50) (show all 2462)
# Title Authors PMID Year
1
Differentiating psychogenic nonepileptic from epileptic seizures: A mixed-methods, content analysis study. 61
32388401 2020
2
Symptoms of depersonalization/derealization are independent risk factors for the development or persistence of psychological distress in the general population: Results from the Gutenberg health study. 61
32421621 2020
3
Dissociation as a disorder of integration - On the footsteps of Pierre Janet. 61
32194203 2020
4
Burnout Phenomenon and Its Predictors in Radiology Residents. 61
31629625 2020
5
Analyzing the Impact of Practice Environment on Nurse Burnout Using Conventional and Multilevel Logistic Regression Models. 61
31983290 2020
6
Describing the emotional exhaustion, depersonalization, and low personal accomplishment symptoms associated with Maslach Burnout Inventory subscale scores in US physicians: an item response theory analysis. 61
32488344 2020
7
Could the connectedness of primary health care workers involved in social networks affect their job burnout? A cross-sectional study in six counties, Central China. 61
32552752 2020
8
Burnout in Pediatric Critical Care Medicine Fellows. 61
32118699 2020
9
Prevalence of Burnout Among Cardiothoracic Radiologists. 61
32555005 2020
10
Strategies of Advanced Practice Providers to Reduce Stress at Work. 61
32491978 2020
11
Burnout and career satisfaction in neuro-oncology: a survey of the Society for Neuro-Oncology and the European Association of Neuro-Oncology memberships. 61
31832657 2020
12
Burnout in Nursing Managers: A Systematic Review and Meta-Analysis of Related Factors, Levels and Prevalence. 61
32512738 2020
13
Prevalence of burnout in mental health nurses in China: A meta-analysis of observational studies. 61
32513464 2020
14
The Relationship Between Residents' Perceptions of Residency Program Leadership Team Behaviors and Resident Burnout and Satisfaction. 61
32520754 2020
15
Work satisfaction and burnout risk of gastroenterologists in Germany: results of a nationwide survey. 61
32512590 2020
16
Data relating to factors affecting teachers' burnout: A sem analysis in an Asian context. 61
32309526 2020
17
Systems to Address Burnout and Support Well-being: Implications for Intensive Care Unit Nurses. 61
32525995 2020
18
Workplace Aggression and Burnout in Nursing-The Moderating Role of Follow-Up Counseling. 61
32369903 2020
19
Factors Associated with Burnout Syndrome in Primary and Secondary School Teachers in the Republic of Srpska (Bosnia and Herzegovina). 61
32443806 2020
20
Job Satisfaction and Its Associated Factors Among General Practitioners in China. 61
32430379 2020
21
Stressors and Coping Mechanisms Related to Burnout Within Urology. 61
32032685 2020
22
Evidence of burnout in critical care pharmacists. 61
32280966 2020
23
Comparison of Burnout and Empathy Among Millennial and Generation X Residents and Fellows: Associations with Training Level and Race but Not Generation Affiliation. 61
32372337 2020
24
Evaluation of a brief cognitive behavioral group intervention to reduce depersonalization in students with high levels of trait test anxiety: a randomized controlled trial. 61
32160798 2020
25
Prospective association between burnout and road traffic accidents in teachers. 61
32407605 2020
26
A network analysis of posttraumatic stress disorder and dissociation in trauma-exposed adolescents. 61
32272318 2020
27
Burnout in providers serving individuals with ASD: The impact of the workplace. 61
32120047 2020
28
The Role of Childhood Maltreatment in The Relationship Between Social Anxiety and Dissociation: A Novel Link. 61
32000621 2020
29
Structural and functional brain alterations in psychiatric patients with dissociative experiences: A systematic review of magnetic resonance imaging studies. 61
32480060 2020
30
Levels of Depersonalization and Derealization Reported by Recovered and Non-recovered Borderline Patients Over 20 Years of Prospective Follow-up. 61
32000616 2020
31
What Is the Prevalence of Burnout, Depression, and Substance Use Among Orthopaedic Surgery Residents and What Are the Risk Factors? A Collaborative Orthopaedic Educational Research Group Survey Study. 61
32452925 2020
32
Psychometric properties of the dissociative symptoms scale (DSS) in Italian outpatients and community adults. 61
32396059 2020
33
Causes and consequences of burnout among mental health professionals: A practice-oriented review of recent empirical literature. 61
32463274 2020
34
Wellness, burnout, and the dermatologist: Fundamentals for practice longevity. 61
32563345 2020
35
Lessons learned: A single academic department's unique approach to preventing physician burnout. 61
32516695 2020
36
Prevalence and Risk Factors for Burnout in Pediatric Emergency Medicine Fellows. 61
32229786 2020
37
The effect of mindfulness training on burnout syndrome in nursing: A systematic review and meta-analysis. 61
32026484 2020
38
Validity and reliability of a Persian version of the Dissociative Experiences Scale II (DES-II) on Iranian patients diagnosed with schizophrenia and mood disorders. 61
31621534 2020
39
Nurses' views on workload, care rationing and work environments. 61
32255223 2020
40
High prevalence of burnout syndrome in orthopedic nurses in Italy. 61
31866212 2020
41
Role stress, social support and occupational burnout among physicians in China: a path analysis approach. 61
31343067 2020
42
Burnout syndrome among nephrologists - a burning issue - results of the countrywide survey by the Polish Society of Nephrology. 61
32398009 2020
43
Prevalence and Predictors of Burnout Among Hospice and Palliative Care Clinicians in the U.S. 61
31778784 2020
44
A Pilot Study of Mindfulness-Based Cognitive Therapy to Improve Well-Being for Health Professionals Providing Chronic Disease Care. 61
32417086 2020
45
Characterization of Burnout Among Spanish Family Physicians Treating Fibromyalgia Patients: The EPIFFAC Study. 61
32430370 2020
46
Perceived Stress and Indicators of Burnout in Teachers at Portuguese Higher Education Institutions (HEI). 61
32392696 2020
47
Assessment of burnout within a health-system pharmacy department. 61
32298409 2020
48
Burnout among Academic Clinicians as It Correlates with Workload and Demographic Variables. 61
32471265 2020
49
From brooding to detachment: Rumination longitudinally predicts an increase in depersonalization and derealisation. 61
32333727 2020
50
142 Withdrawal Symptom Assessment in an Esketamine Safety Study in Patients with Treatment-resistant Depression. 61
32331032 2020

Variations for Depersonalization Disorder

Expression for Depersonalization Disorder

Search GEO for disease gene expression data for Depersonalization Disorder.

Pathways for Depersonalization Disorder

GO Terms for Depersonalization Disorder

Cellular components related to Depersonalization Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell junction GO:0030054 9.77 GRIN3B GRIN3A GRIK4 GRIK3 GRID2
2 postsynaptic membrane GO:0045211 9.55 GRIN3B GRIN3A GRIK4 GRIK3 GRID2
3 synapse GO:0045202 9.5 PNOC HAPLN1 GRIN3B GRIN3A GRIK4 GRIK3
4 NMDA selective glutamate receptor complex GO:0017146 9.32 GRIN3B GRIN3A
5 kainate selective glutamate receptor complex GO:0032983 9.26 GRIK4 GRIK3
6 postsynaptic density membrane GO:0098839 9.02 GRIN3B GRIN3A GRIK4 GRIK3 GRID2

Biological processes related to Depersonalization Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.8 GRIN3B GRIN3A GRIK4 GRIK3 GRID2
2 ion transmembrane transport GO:0034220 9.77 GRIN3B GRIN3A GRIK4 GRIK3 GRID2
3 regulation of postsynaptic membrane potential GO:0060078 9.56 GRIN3B GRIN3A GRIK4 GRIK3
4 modulation of chemical synaptic transmission GO:0050804 9.55 GRIN3B GRIN3A GRIK4 GRIK3 GRID2
5 glutamate receptor signaling pathway GO:0007215 9.5 GRIK4 GRIK3 GRID2
6 prepulse inhibition GO:0060134 9.43 GRIN3A GRID2
7 synaptic transmission, glutamatergic GO:0035249 9.35 GRIN3B GRIN3A GRIK4 GRIK3 GRID2
8 ionotropic glutamate receptor signaling pathway GO:0035235 9.02 GRIN3B GRIN3A GRIK4 GRIK3 GRID2

Molecular functions related to Depersonalization Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 9.77 GRIN3B GRIN3A GRIK4 GRIK3 GRID2
2 ion channel activity GO:0005216 9.72 GRIN3B GRIN3A GRIK4 GRIK3 GRID2
3 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential GO:1904315 9.65 GRIN3B GRIN3A GRIK4 GRIK3 GRID2
4 ligand-gated ion channel activity GO:0015276 9.55 GRIN3B GRIN3A GRIK4 GRIK3 GRID2
5 glycine binding GO:0016594 9.46 GRIN3B GRIN3A
6 NMDA glutamate receptor activity GO:0004972 9.43 GRIN3B GRIN3A
7 kainate selective glutamate receptor activity GO:0015277 9.4 GRIK4 GRIK3
8 glutamate receptor activity GO:0008066 9.35 GRIN3B GRIN3A GRIK4 GRIK3 GRID2
9 ionotropic glutamate receptor activity GO:0004970 9.02 GRIN3B GRIN3A GRIK4 GRIK3 GRID2

Sources for Depersonalization Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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