MCID: DPR002
MIFTS: 40

Depersonalization Disorder

Categories: Eye diseases, Mental diseases, Neuronal diseases

Aliases & Classifications for Depersonalization Disorder

MalaCards integrated aliases for Depersonalization Disorder:

Name: Depersonalization Disorder 12 76 15 73
Depersonalization 44 73
Neurotic Derealization 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11038
ICD9CM 35 300.6
MeSH 44 D003861
NCIt 50 C94331
SNOMED-CT 68 70764005

Summaries for Depersonalization Disorder

Disease Ontology : 12 A dissociative disorder in which the sufferer is affected by persistent or recurrent feelings of depersonalization and/or derealization.

MalaCards based summary : Depersonalization Disorder, also known as depersonalization, is related to depersonalization/derealization disorder and dissociative disorder, and has symptoms including symptoms, feeling detached and feeling strange. An important gene associated with Depersonalization Disorder is TNFSF11 (TNF Superfamily Member 11), and among its related pathways/superpathways are NF-kappaB Signaling and Apoptosis and Autophagy. The drugs Fluoxetine and Cytochrome P-450 CYP2D6 Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include eye, cortex and testes.

Wikipedia : 76 Depersonalization disorder (DPD), also known as depersonalization/derealization disorder, is a mental... more...

Related Diseases for Depersonalization Disorder

Diseases related to Depersonalization Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 26)
# Related Disease Score Top Affiliating Genes
1 depersonalization/derealization disorder 11.8
2 dissociative disorder 11.4
3 panic disorder 10.3
4 epilepsy 10.2
5 temporal lobe epilepsy 10.1
6 schizophrenia 10.1
7 alexithymia 10.1
8 depression 10.1
9 bipolar disorder 10.0
10 koro 10.0
11 obsessive-compulsive disorder 9.9
12 anxiety 9.9
13 multiple sclerosis 9.9
14 autism 9.9
15 borderline personality disorder 9.9
16 social phobia 9.9
17 hypochondriasis 9.9
18 personality disorder 9.9
19 impotence 9.9
20 focal epilepsy 9.9
21 complex regional pain syndrome 9.9
22 neurotic disorder 9.9
23 agoraphobia 9.9
24 decubitus ulcer 9.9
25 cannabis abuse 9.9
26 headache 9.9

Graphical network of the top 20 diseases related to Depersonalization Disorder:



Diseases related to Depersonalization Disorder

Symptoms & Phenotypes for Depersonalization Disorder

UMLS symptoms related to Depersonalization Disorder:


symptoms, feeling detached, feeling strange, feeling weightless, floating feeling, affective symptoms, behavioral symptoms, schizophrenic language

Drugs & Therapeutics for Depersonalization Disorder

Drugs for Depersonalization Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluoxetine Approved, Vet_approved Not Applicable 54910-89-3 3386
2 Cytochrome P-450 CYP2D6 Inhibitors Not Applicable
3 Psychotropic Drugs Not Applicable
4 Neurotransmitter Uptake Inhibitors Not Applicable
5 Cytochrome P-450 Enzyme Inhibitors Not Applicable
6 Antidepressive Agents Not Applicable
7 Neurotransmitter Agents Not Applicable
8 Serotonin Uptake Inhibitors Not Applicable
9 Serotonin Agents Not Applicable
10 Antidepressive Agents, Second-Generation Not Applicable
11
Serotonin Investigational, Nutraceutical Not Applicable 50-67-9 5202

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Depersonalization Disorder With Transcranial Magnetic Stimulation (TMS) Completed NCT00529217 Phase 2
2 Treatment of Depersonalization Disorder With Repetitive Transcranial Magnetic Stimulation (rTMS) Withdrawn NCT02256085 Phase 2
3 Study of Fluoxetine in Patients With Depersonalization Disorder Completed NCT00004446 Not Applicable fluoxetine
4 Depersonalization Disorder: Therapeutic Effect of Neuronavigated Repetitive Transcranial Stimulation Recruiting NCT02476435 Not Applicable

Search NIH Clinical Center for Depersonalization Disorder

Cochrane evidence based reviews: depersonalization

Genetic Tests for Depersonalization Disorder

Anatomical Context for Depersonalization Disorder

MalaCards organs/tissues related to Depersonalization Disorder:

41
Eye, Cortex, Testes, Temporal Lobe, Pituitary, Skin, Prefrontal Cortex

Publications for Depersonalization Disorder

Articles related to Depersonalization Disorder:

(show top 50) (show all 326)
# Title Authors Year
1
Anomalous Self-Experiences: Markers of Schizophrenia Vulnerability or Symptoms of Depersonalization Disorder? A Phenomenological Investigation of Two Cases. ( 29730662 )
2018
2
White matter network alterations in patients with depersonalization/derealization disorder. ( 30125247 )
2018
3
Depersonalization, adversity, emotionality, and coping with stressful situations. ( 28509616 )
2018
4
What was once essential, may become detrimental: The mediating role of depersonalization in the relationship between childhood emotional maltreatment and psychological distress in adults. ( 29144883 )
2018
5
Emotion regulation strategies moderate the relationship of fatigue with depersonalization and derealization symptoms. ( 29172049 )
2018
6
Resting-State Networks of Adolescents Experiencing Depersonalization-Like Illusions: Cross-sectional and Longitudinal Findings. ( 29566227 )
2018
7
Resolution of Acute-Onset Depersonalization/Derealization With Clonazepam and Inpatient Hospitalization. ( 29601318 )
2018
8
The depersonalized brain: New evidence supporting a distinction between depersonalization and derealization from discrete patterns of autonomic suppression observed in a non-clinical sample. ( 29929064 )
2018
9
Depersonalization Under Academic Stress: Frequency, Predictors, and Consequences. ( 29945133 )
2018
10
Third-Year Medical Students' Reactions to Surgical Patients in Pain: Doubt, Distress, and Depersonalization. ( 30144537 )
2018
11
High Betrayal Adolescent Sexual Abuse and Nonsuicidal Self-Injury: The Role of Depersonalization in Emerging Adults. ( 30403925 )
2018
12
Treatment of Depersonalization Disorder With Repetitive Transcranial Magnetic Stimulation. ( 28291040 )
2017
13
Treatment of a Patient With Depersonalization Disorder With Low Frequency Repetitive Transcranial Magnetic Stimulation of the Right Temporo-Parietal Junction in a Private Practice Setting. ( 28291041 )
2017
14
Depersonalization and derealization in self-report and clinical interview: The spectrum of borderline personality disorder, dissociative disorders, and healthy controls. ( 27681414 )
2017
15
Dual role as a protective factor for burnout-related depersonalization in oncologists. ( 28317213 )
2017
16
Daily Elevations in Dissociative Absorption and Depersonalization in a Nonclinical Sample Are Related to Daily Stress and Psychopathological Symptoms. ( 29087250 )
2017
17
The Dissociative Subtype of Posttraumatic Stress Disorder (PTSD) Among Adolescents: Co-Occurring PTSD, Depersonalization/Derealization, and Other Dissociation Symptoms. ( 29173740 )
2017
18
Ventrolateral prefrontal cortex repetitive transcranial magnetic stimulation in the treatment of depersonalization disorder: A consecutive case series. ( 27104926 )
2016
19
Emotional Experience and Awareness of Self: Functional MRI Studies of Depersonalization Disorder. ( 27313548 )
2016
20
Dissociable brain correlates for depression, anxiety, dissociation, and somatization in depersonalization-derealization disorder. ( 24059962 )
2016
21
Cognitive load and autonomic response patterns under negative priming demand in depersonalization-derealization disorder. ( 26791018 )
2016
22
Cardiac modulation of startle is altered in depersonalization-/derealization disorder: Evidence for impaired brainstem representation of baro-afferent neural traffic. ( 27078753 )
2016
23
Pain and tactile dissociation, derealization and depersonalization symptoms in women and recalled traumatic events in childhood, adolescence and early adulthood. ( 27086330 )
2016
24
Differential Diagnosis of an Elderly Manic-Depressive Patient with Depersonalization and Other Symptoms. ( 27293942 )
2016
25
A case series of 223 patients with depersonalization-derealization syndrome. ( 27349226 )
2016
26
The relationship of depersonalization and absorption to hallucinations in psychotic and non-clinical participants. ( 27525824 )
2016
27
Tracking Potentiating States of Dissociation: An Intensive Clinical Case Study of Sleep, Daydreaming, Mood, and Depersonalization/Derealization. ( 27582722 )
2016
28
Older women deserve more than chaos and depersonalization. ( 27814134 )
2016
29
RELIABILITY, VALIDITY, AND PSYCHOMETRIC PROPERTIES OF THE GREEK TRANSLATION OF THE CAMBRIDGE DEPERSONALIZATION SCALE (CDS). ( 27999491 )
2016
30
Abnormal cardiovascular sympathetic and parasympathetic responses to physical and emotional stimuli in depersonalization disorder. ( 25859177 )
2015
31
Prevalence and correlates of depersonalization in students aged 12-18 years in Germany. ( 25201182 )
2015
32
Symptom profiles in depersonalization and anxiety disorders: an analysis of the Beck Anxiety Inventory. ( 25401973 )
2015
33
Organic depersonalization as a chronic sequela of mefloquine intoxication. ( 25619679 )
2015
34
Depersonalization: physiological or pathological in adolescents? ( 25748214 )
2015
35
Depersonalization: An exploratory factor analysis of the Italian version of the Cambridge Depersonalization Scale. ( 25863646 )
2015
36
The Occurrence of Depersonalization Symptoms After Accelerated HF-rTMS of the Left DLPFC in a Patient With Treatment-resistant Depression: A Case Report. ( 25865771 )
2015
37
"I HEAR MY VOICE, BUT WHO IS TALKING?": UNDERSTANDING DEPERSONALIZATION. ( 26443948 )
2015
38
A disembodied man: A case of somatopsychic depersonalization in schizotypal disorder. ( 26571072 )
2015
39
Vestibular Function and Depersonalization/Derealization Symptoms. ( 26595960 )
2015
40
Aripiprazole in depersonalization disorder comorbid with major depression and obsessive-compulsive disorder: 3 cases. ( 24992087 )
2014
41
Grey matter alterations in patients with depersonalization disorder: a voxel-based morphometry study. ( 25285875 )
2014
42
Altered orientation of spatial attention in depersonalization disorder. ( 24594203 )
2014
43
Testing a neurobiological model of depersonalization disorder using repetitive transcranial magnetic stimulation. ( 24439959 )
2014
44
Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on Specific Symptom Clusters in Depersonalization Disorder (DPD). ( 23941986 )
2014
45
Psychometric properties of the Cambridge depersonalization scale in Puerto Rico. ( 24283777 )
2014
46
Face processing in depersonalization: an fMRI study of the unfamiliar self. ( 24582597 )
2014
47
Striking discrepancy of anomalous body experiences with normal interoceptive accuracy in depersonalization-derealization disorder. ( 24587061 )
2014
48
Prolonged depersonalization/derealization-like symptom after migraine headache: a case report. ( 24752392 )
2014
49
Anxiety changes depersonalization and derealization symptoms in vestibular patients. ( 24803735 )
2014
50
How do you feel when you can't feel your body? Interoception, functional connectivity and emotional processing in depersonalization-derealization disorder. ( 24967634 )
2014

Variations for Depersonalization Disorder

Expression for Depersonalization Disorder

Search GEO for disease gene expression data for Depersonalization Disorder.

Pathways for Depersonalization Disorder

Pathways related to Depersonalization Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.67 BCL10 TNFSF11
2 11.22 BCL10 TNFSF11
3 10.6 BCL10 TNFSF11

GO Terms for Depersonalization Disorder

Cellular components related to Depersonalization Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 8.62 BCL10 RAP1B

Biological processes related to Depersonalization Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homooligomerization GO:0051260 9.32 BCL10 TNFSF11
2 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.26 BCL10 TNFSF11
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.16 BCL10 TNFSF11
4 positive regulation of phosphorylation GO:0042327 8.96 BCL10 TNFSF11
5 positive regulation of T cell activation GO:0050870 8.62 BCL10 TNFSF11

Sources for Depersonalization Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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