MCID: DPR002
MIFTS: 36

Depersonalization Disorder

Categories: Mental diseases, Neuronal diseases

Aliases & Classifications for Depersonalization Disorder

MalaCards integrated aliases for Depersonalization Disorder:

Name: Depersonalization Disorder 12 76 15 73
Depersonalization 44 73
Neurotic Derealization 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11038
ICD9CM 35 300.6
MeSH 44 D003861
NCIt 50 C94331
SNOMED-CT 68 70764005

Summaries for Depersonalization Disorder

Disease Ontology : 12 A dissociative disorder in which the sufferer is affected by persistent or recurrent feelings of depersonalization and/or derealization.

MalaCards based summary : Depersonalization Disorder, also known as depersonalization, is related to depersonalization/derealization disorder and alexithymia, and has symptoms including affective symptoms, behavioral symptoms and schizophrenic language. An important gene associated with Depersonalization Disorder is TNFSF11 (TNF Superfamily Member 11), and among its related pathways/superpathways are NF-kappaB Signaling and Apoptosis and Autophagy. The drugs Fluoxetine and Antidepressive Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, pituitary and prefrontal cortex.

Wikipedia : 76 Depersonalization disorder (DPD), also known as depersonalization/derealization disorder, is a mental... more...

Related Diseases for Depersonalization Disorder

Diseases related to Depersonalization Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 depersonalization/derealization disorder 11.6
2 alexithymia 10.0
3 depression 10.0
4 obsessive-compulsive disorder 9.8
5 schizophrenia 9.8
6 anxiety 9.8

Graphical network of the top 20 diseases related to Depersonalization Disorder:



Diseases related to Depersonalization Disorder

Symptoms & Phenotypes for Depersonalization Disorder

UMLS symptoms related to Depersonalization Disorder:


affective symptoms, behavioral symptoms, schizophrenic language, feeling detached, feeling strange, feeling weightless, floating feeling, symptoms

Drugs & Therapeutics for Depersonalization Disorder

Drugs for Depersonalization Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluoxetine Approved, Vet_approved Not Applicable 54910-89-3 3386
2 Antidepressive Agents Not Applicable
3 Antidepressive Agents, Second-Generation Not Applicable
4 Cytochrome P-450 CYP2D6 Inhibitors Not Applicable
5 Cytochrome P-450 Enzyme Inhibitors Not Applicable
6 Neurotransmitter Agents Not Applicable
7 Neurotransmitter Uptake Inhibitors Not Applicable
8 Psychotropic Drugs Not Applicable
9 Serotonin Agents Not Applicable
10 Serotonin Uptake Inhibitors Not Applicable
11
Serotonin Investigational, Nutraceutical Not Applicable 50-67-9 5202

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Depersonalization Disorder With Transcranial Magnetic Stimulation (TMS) Completed NCT00529217 Phase 2
2 Treatment of Depersonalization Disorder With Repetitive Transcranial Magnetic Stimulation (rTMS) Withdrawn NCT02256085 Phase 2
3 Study of Fluoxetine in Patients With Depersonalization Disorder Completed NCT00004446 Not Applicable fluoxetine
4 Depersonalization Disorder: Therapeutic Effect of Neuronavigated Repetitive Transcranial Stimulation Recruiting NCT02476435 Not Applicable

Search NIH Clinical Center for Depersonalization Disorder

Cochrane evidence based reviews: depersonalization

Genetic Tests for Depersonalization Disorder

Anatomical Context for Depersonalization Disorder

MalaCards organs/tissues related to Depersonalization Disorder:

41
Eye, Pituitary, Prefrontal Cortex, Skin, Cortex, Testes

Publications for Depersonalization Disorder

Articles related to Depersonalization Disorder:

(show top 50) (show all 69)
# Title Authors Year
1
Anomalous Self-Experiences: Markers of Schizophrenia Vulnerability or Symptoms of Depersonalization Disorder? A Phenomenological Investigation of Two Cases. ( 29730662 )
2018
2
Treatment of Depersonalization Disorder With Repetitive Transcranial Magnetic Stimulation. ( 28291040 )
2017
3
Treatment of a Patient With Depersonalization Disorder With Low Frequency Repetitive Transcranial Magnetic Stimulation of the Right Temporo-Parietal Junction in a Private Practice Setting. ( 28291041 )
2017
4
Ventrolateral prefrontal cortex repetitive transcranial magnetic stimulation in the treatment of depersonalization disorder: A consecutive case series. ( 27104926 )
2016
5
Emotional Experience and Awareness of Self: Functional MRI Studies of Depersonalization Disorder. ( 27313548 )
2016
6
Abnormal cardiovascular sympathetic and parasympathetic responses to physical and emotional stimuli in depersonalization disorder. ( 25859177 )
2015
7
Aripiprazole in depersonalization disorder comorbid with major depression and obsessive-compulsive disorder: 3 cases. ( 24992087 )
2014
8
Grey matter alterations in patients with depersonalization disorder: a voxel-based morphometry study. ( 25285875 )
2014
9
Altered orientation of spatial attention in depersonalization disorder. ( 24594203 )
2014
10
Testing a neurobiological model of depersonalization disorder using repetitive transcranial magnetic stimulation. ( 24439959 )
2014
11
Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on Specific Symptom Clusters in Depersonalization Disorder (DPD). ( 23941986 )
2014
12
Interoceptive-reflective regions differentiate alexithymia traits in depersonalization disorder. ( 23932225 )
2013
13
Depersonalization disorder: disconnection of cognitive evaluation from autonomic responses to emotional stimuli. ( 24058547 )
2013
14
Preliminary physiological evidence for impaired emotion regulation in depersonalization disorder. ( 23507419 )
2013
15
Depicting depersonalization disorder. ( 23450287 )
2013
16
Implicit self-esteem in borderline personality and depersonalization disorder. ( 22493585 )
2012
17
Conditional reasoning in Asperger's syndrome and depersonalization disorder. ( 22922241 )
2012
18
Depersonalization disorder and anxiety: a special relationship? ( 22414660 )
2012
19
Multiple clinical traits predict clinical diagnosis of depersonalization disorder: implications for DSM-V. ( 22206878 )
2012
20
Who is the man in the mirror? Depersonalization disorder after obesity surgery. ( 21640666 )
2012
21
Psychophysiological investigations in depersonalization disorder and effects of electrodermal biofeedback. ( 22545565 )
2012
22
Cannabis-induced depersonalization disorder in adolescence. ( 22378193 )
2012
23
Depersonalization disorder may be related to glutamate receptor activation imbalance. ( 21742442 )
2011
24
The efficacy of lamotrigine in a resistant case of depersonalization disorder. ( 21769750 )
2011
25
Temporo-parietal junction stimulation in the treatment of depersonalization disorder. ( 20837362 )
2011
26
Lamotrigine in the immediate treatment of outpatients with depersonalization disorder without psychiatric comorbidity: randomized, double-blind, placebo-controlled study. ( 21192145 )
2011
27
Methylphenidate in depersonalization disorder: a case report. ( 21274825 )
2011
28
Skin conductance and memory fragmentation after exposure to an emotional film clip in depersonalization disorder. ( 20381160 )
2010
29
Depersonalization disorder. ( 20308898 )
2010
30
Is depersonalization disorder initiated by illicit drug use any different? A survey of 394 adults. ( 19538903 )
2009
31
Alexithymia, absorption, and cognitive failures in depersonalization disorder: a comparison to posttraumatic stress disorder and healthy volunteers. ( 19597356 )
2009
32
Reliability and validity of a Japanese version of the Cambridge depersonalization scale as a screening instrument for depersonalization disorder. ( 19566762 )
2009
33
ECEM (Eye Closure, Eye Movements): application to depersonalization disorder. ( 19862896 )
2009
34
Somatoform dissociation in depersonalization disorder. ( 19042782 )
2008
35
Depersonalization disorder: pharmacological approaches. ( 18088198 )
2008
36
Emotional memory and perception of emotional faces in patients suffering from depersonalization disorder. ( 17705944 )
2007
37
Temporal disintegration in depersonalization disorder. ( 17409052 )
2007
38
Lamotrigine as an add-on treatment for depersonalization disorder: a retrospective study of 32 cases. ( 16960469 )
2006
39
Autonomic response in the perception of disgust and happiness in depersonalization disorder. ( 17074399 )
2006
40
Quetiapine: focus on emotional numbing in depersonalization disorder: an fMRI case report. ( 16140509 )
2006
41
Emotional memory in depersonalization disorder: a functional MRI study. ( 17085021 )
2006
42
An open trial of naltrexone in the treatment of depersonalization disorder. ( 15876908 )
2005
43
Role of fantasy proneness, imaginative involvement, and psychological absorption in depersonalization disorder. ( 14718779 )
2004
44
Migraine and depersonalization disorder. ( 15265059 )
2004
45
A placebo-controlled, cross-over trial of lamotrigine in depersonalization disorder. ( 12680746 )
2003
46
Examination of the pathological dissociation taxon in depersonalization disorder. ( 14614341 )
2003
47
Basal norepinephrine in depersonalization disorder. ( 14572626 )
2003
48
Feeling unreal: a depersonalization disorder update of 117 cases. ( 14628973 )
2003
49
Depersonalization disorder: a functional neuroanatomical perspective. ( 13129809 )
2003
50
Autonomic response in depersonalization disorder. ( 12215083 )
2002

Variations for Depersonalization Disorder

Expression for Depersonalization Disorder

Search GEO for disease gene expression data for Depersonalization Disorder.

Pathways for Depersonalization Disorder

Pathways related to Depersonalization Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.67 BCL10 TNFSF11
2 11.22 BCL10 TNFSF11
3 10.6 BCL10 TNFSF11

GO Terms for Depersonalization Disorder

Cellular components related to Depersonalization Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 8.62 BCL10 RAP1B

Biological processes related to Depersonalization Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homooligomerization GO:0051260 9.32 BCL10 TNFSF11
2 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.26 BCL10 TNFSF11
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.16 BCL10 TNFSF11
4 positive regulation of phosphorylation GO:0042327 8.96 BCL10 TNFSF11
5 positive regulation of T cell activation GO:0050870 8.62 BCL10 TNFSF11

Sources for Depersonalization Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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