MCID: DRM053
MIFTS: 67

Dermatitis, Atopic

Categories: Skin diseases, Respiratory diseases, Neuronal diseases, Immune diseases, Genetic diseases

Aliases & Classifications for Dermatitis, Atopic

MalaCards integrated aliases for Dermatitis, Atopic:

Name: Dermatitis, Atopic 57 29 44 73
Atopic Dermatitis 12 76 25 37 6 15
Atopic Eczema 12 25
Dermatitis, Atopic, Susceptibility to, 1 57
Atopic Neurodermatitis 12
Dermatitis, Atopic, 1 13
Dermatitis, Atopic 1 57
Allergic Dermatitis 12
Besnier's Prurigo 12
Dermatitis Atopic 55
Eczema, Atopic 57
Allergic 12
Eczema 73
Atod 57

Characteristics:

OMIM:

57
Miscellaneous:
food intolerance
diagnosis requires 3 major features (a positive family history is also considered a major feature) and at least 3 minor features

Inheritance:
autosomal dominant


HPO:

32
dermatitis, atopic:
Inheritance autosomal dominant inheritance


Classifications:



Summaries for Dermatitis, Atopic

Genetics Home Reference : 25 Atopic dermatitis (also known as atopic eczema) is a disorder characterized by inflammation of the skin (dermatitis). The condition usually begins in early infancy, and it often disappears before adolescence. However, in some affected individuals the condition continues into adulthood; in others, it does not begin until adulthood. Hallmarks of atopic dermatitis include dry, itchy skin and red rashes that come and go. The rashes can occur on any part of the body, although the pattern tends to be different at different ages. In affected infants, the rashes commonly occur on the face, scalp, hands, and feet. In children, the rashes are usually found in the bend of the elbows and knees and on the front of the neck. In adolescents and adults, the rashes typically occur on the wrists, ankles, and eyelids in addition to the bend of the elbows and knees. Scratching the itchy skin can lead to oozing and crusting of the rashes and thickening and hardening (lichenification) of the skin. The itchiness can be so severe as to disturb sleep and impair a person's quality of life.

MalaCards based summary : Dermatitis, Atopic, also known as atopic dermatitis, is related to dermatitis, atopic, 3 and dermatitis, and has symptoms including exanthema and pruritus. An important gene associated with Dermatitis, Atopic is MIR155 (MicroRNA 155
miR-155 was one of the highest-ranked upregulated miRNAs in patients with atopic dermatitis. In the skin miR-155 was predominantly expressed in infiltrating immune cells. miR-155 was upregulated during T-cell differentiation/activation and was markedly induced by T-cell activators in PBMCs in vitro and by superantigens and allergens in the skin in vivo. CTLA-4, an important negative regulator of T-cell activation, was identified as a direct target of miR-155. Overexpression of miR-155 in T(H) cells resulted in decreased CTLA-4 levels accompanied by an increased proliferative response.), and among its related pathways/superpathways are Allograft rejection and Regulation of IFNA signaling. The drugs Montelukast and Petrolatum have been mentioned in the context of this disorder. Affiliated tissues include the skin, skin and testes, and related phenotypes are conjunctivitis and cataract

Disease Ontology : 12 A dermatitis that is a chronically relapsing inflammatory allergic response located in the skin that causes itching and flaking.

OMIM : 57 Atopic dermatitis (ATOD), also known as eczema, is a common chronic pruritic inflammatory skin disease with a strong genetic component. Onset typically occurs during the first 2 years of life (review by Soderhall et al., 2007). (603165)

Wikipedia : 76 Atopic dermatitis (AD), also known as atopic eczema, is a type of inflammation of the skin (dermatitis).... more...

Related Diseases for Dermatitis, Atopic

Diseases in the Dermatitis, Atopic family:

Dermatitis, Atopic, 2 Dermatitis, Atopic, 3
Dermatitis, Atopic, 4 Dermatitis, Atopic, 5
Dermatitis, Atopic, 6 Dermatitis, Atopic, 7
Dermatitis, Atopic, 8 Dermatitis, Atopic, 9

Diseases related to Dermatitis, Atopic via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 123)
# Related Disease Score Top Affiliating Genes
1 dermatitis, atopic, 3 35.3 ATOD3 FLG
2 dermatitis 31.9 CCL17 CCL22 FLG IFNG IL13 IL31
3 allergic contact dermatitis 31.5 CCL17 FLG IFNG IL31 IL4 IL5
4 contact dermatitis 31.4 CCL17 CCL22 FLG IFNG IL31 IL4
5 rhinitis 31.3 IL13 IL4 IL5 RNASE3
6 allergic rhinitis 31.2 IFNG IL13 IL4 IL5 MS4A2 RNASE3
7 skin disease 31.1 CCL17 FLG IFNG IL13 IL31 IL4
8 asthma 30.6 CCL17 CCL22 FLG IFNG IL13 IL31
9 dermatitis, atopic, 2 12.5
10 dermatitis, atopic, 4 12.2
11 dermatitis, atopic, 5 12.2
12 dermatitis, atopic, 6 12.2
13 dermatitis, atopic, 7 12.2
14 dermatitis, atopic, 8 12.2
15 dermatitis, atopic, 9 12.2
16 cough variant asthma 11.3 IL4 IL5 RNASE3
17 angiostrongyliasis 11.3 IL13 IL4 IL5
18 necatoriasis 11.3 CCL17 CCL22 IL5
19 mycoplasmal pneumonia 11.3 IFNG IL4
20 eczema herpeticum 11.3 FLG IFNG TSLP
21 penicillin allergy 11.3 IFNG IL13 IL4
22 intrinsic asthma 11.3 IL4 IL5 RNASE3
23 ascaris lumbricoides infection 11.3 IL13 IL5 TSLP
24 eosinophilic meningitis 11.3 IL13 IL4 IL5
25 cytokine deficiency 11.3 IL13 IL5
26 esophagitis, eosinophilic, 1 11.3 FLG IL13 IL5 TSLP
27 intestinal schistosomiasis 11.3 IL13 IL4 IL5
28 eosinophilic gastritis 11.3 IL13 IL4 IL5
29 chronic tic disorder 11.3 IL13 IL4 IL5
30 orofacial granulomatosis 11.3 FLG IFNG IL4
31 strongyloidiasis 11.3 IFNG IL13 IL5
32 inflammatory bowel disease 4 11.3 IL13 IL4 IL5 RNASE3
33 allergic bronchopulmonary aspergillosis 11.2 CCL17 IL4 IL5
34 paragonimiasis 11.2 CCL17 IL13 IL5 RNASE3
35 gastrointestinal allergy 11.2 IL4 IL5 RNASE3 TSLP
36 kimura disease 11.2 IL4 IL5 RNASE3 TSLP
37 peanut allergy 11.2 CCL22 FLG IFNG IL13
38 folliculitis 11.2 IFNG IL4 IL5
39 enterobiasis 11.2 IL13 IL4 IL5
40 vernal keratoconjunctivitis 11.2 IL13 IL4 IL5 RNASE3
41 toxic oil syndrome 11.2 IFNG IL4 IL5
42 eosinophilic fasciitis 11.2 IFNG IL5
43 onchocerciasis 11.2 IL13 IL4 IL5 RNASE3
44 esophageal disease 11.2 IL13 IL5 TSLP
45 pollen allergy 11.2 IL13 IL5 RNASE3
46 paranasal sinus disease 11.2 IFNG IL13 IL4 IL5
47 parasitic helminthiasis infectious disease 11.2 IL13 IL4 IL5 RNASE3
48 milk allergy 11.2 IL4 IL5 RNASE3
49 leukocyte disease 11.2 IL13 IL4 IL5 RNASE3
50 common cold 11.2 IL13 IL5 RNASE3 TSLP

Graphical network of the top 20 diseases related to Dermatitis, Atopic:



Diseases related to Dermatitis, Atopic

Symptoms & Phenotypes for Dermatitis, Atopic

Symptoms via clinical synopsis from OMIM:

57
Skin Nails Hair Skin:
ichthyosis
facial erythema
keratosis pilaris
xerosis
pruritus (major feature)
more
Head And Neck Nose:
allergic rhinitis

Immunology:
elevated ige

Head And Neck Eyes:
keratoconus
cataracts (anterior- subcapsular)
conjunctivitis (recurrent)
orbital darkening

Respiratory Airways:
bronchial asthma

Laboratory Abnormalities:
immediate (type i) skin test reactivity


Clinical features from OMIM:

603165

Human phenotypes related to Dermatitis, Atopic:

32 (show all 17)
# Description HPO Frequency HPO Source Accession
1 conjunctivitis 32 HP:0000509
2 cataract 32 HP:0000518
3 keratoconus 32 HP:0000563
4 dry skin 32 HP:0000958
5 eczema 32 HP:0000964
6 pallor 32 HP:0000980
7 pruritus 32 HP:0000989
8 facial erythema 32 HP:0001041
9 atopic dermatitis 32 HP:0001047
10 recurrent skin infections 32 HP:0001581
11 abnormality of metabolism/homeostasis 32 HP:0001939
12 asthma 32 HP:0002099
13 allergic rhinitis 32 HP:0003193
14 flexural lichenification 32 HP:0007453
15 ichthyosis 32 HP:0008064
16 infra-orbital fold 32 HP:0011232
17 food intolerance 32 HP:0012537

UMLS symptoms related to Dermatitis, Atopic:


exanthema, pruritus

Drugs & Therapeutics for Dermatitis, Atopic

Drugs for Dermatitis, Atopic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 411)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Montelukast Approved Phase 4,Not Applicable 158966-92-8 5281040
2
Petrolatum Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 8009-03-8
3
Bacitracin Approved, Vet_approved Phase 4 1405-87-4 439542 10909430
4
Bronopol Approved Phase 4 52-51-7
5
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-23-7 5754
6 Parthenolide Approved, Investigational Phase 4 20554-84-1
7
Desonide Approved, Investigational Phase 4,Phase 3 638-94-8 5311066
8
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 75614-87-8, 51-45-6 774
9
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83-43-2 6741
10
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-24-8 5755
11
Betamethasone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 378-44-9 9782
12
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2 7440-66-6 23994
13
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 104987-11-3 445643 439492
14
Pimecrolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 137071-32-0 6447131 17753757
15
Fluocinonide Approved, Investigational Phase 4,Not Applicable 356-12-7 9642
16
Fluticasone Approved, Experimental, Investigational Phase 4,Phase 3 90566-53-3 62924
17
Desoximetasone Approved Phase 4 382-67-2 5311067
18
Cortisone acetate Approved, Investigational Phase 4,Phase 2 1950-04-4, 50-04-4 5745
19
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 22916-47-8 4189
20
Cetirizine Approved Phase 4,Phase 3,Phase 2 83881-51-0 2678
21
Levocetirizine Approved Phase 4,Phase 3 130018-77-8 1549000
22
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 124-94-7 31307
23
Omalizumab Approved, Investigational Phase 4,Phase 2,Phase 1 242138-07-4
24
Glycerol Approved, Investigational Phase 4,Phase 3,Not Applicable 56-81-5 753
25
Mupirocin Approved, Investigational, Vet_approved Phase 4 12650-69-0 446596
26
Epinephrine Approved, Vet_approved Phase 4,Phase 2 51-43-4 5816
27
Racepinephrine Approved Phase 4,Phase 2 329-65-7 838
28
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 1994-09-7, 94-09-7 2337
29
Triclosan Approved, Investigational Phase 4 3380-34-5 5564
30
Clobetasol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 25122-46-7, 25122-41-2 32798 5311051
31
Alitretinoin Approved, Investigational Phase 4,Phase 3 5300-03-8 444795 449171
32
Sorbitol Approved Phase 4 50-70-4 5780
33
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 12560
34
Insulin glulisine Approved Phase 4 207748-29-6
35
Clotrimazole Approved, Vet_approved Phase 4 23593-75-1 2812
36
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Not Applicable 50-14-6 5280793
37
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 1406-16-2
38
Vitamin D3 Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Not Applicable 67-97-0 6221 5280795
39
Chitosan Approved, Nutraceutical Phase 4,Phase 2,Not Applicable 9012-76-4 71853
40
Glucosamine Approved, Investigational, Nutraceutical Phase 4 3416-24-8 439213
41 tannic acid Approved, Nutraceutical Phase 4,Phase 3,Phase 1,Phase 2
42
Tretinoin Approved, Investigational, Nutraceutical Phase 4,Phase 3 302-79-4 5538 444795
43
Butyric Acid Experimental, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 107-92-6 264
44
BCG vaccine Investigational Phase 4,Phase 3
45
Lactitol Investigational Phase 4 585-86-4 3871
46 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
47 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
48 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
49 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
50 Leukotriene Antagonists Phase 4,Not Applicable

Interventional clinical trials:

(show top 50) (show all 861)
# Name Status NCT ID Phase Drugs
1 Does Treatment With Montelukast Improve Symptoms of Atopic Dermatitis in Children? Unknown status NCT02534467 Phase 4 Montelukast
2 Efficacy of KAM2904 Face Cream and KAM3008 Body Lotion Treatment in Children With Atopic Dermatitis (AD) Unknown status NCT01781663 Phase 4
3 Effect of Moisturizing Creams on Skin Barrier Function Unknown status NCT00771121 Phase 4 urea/lactic acid;Placebo
4 Clinical Evaluation of T.R.U.E. Test Allergens in Children an Adolescents Unknown status NCT01797562 Phase 4 T.R.U.E. Test Panel 3.2
5 The Randomized Controlled Clinical Trial of Kushen Injection Unknown status NCT02346318 Phase 4 Compound Kushen Injection
6 Efficacy and Tolerability of New Topical Formulations in Subjects With Atopic Dermatitis Completed NCT02732314 Phase 4 Investigational OTC Cream;0.05% Desonide Cream
7 An Efficacy and Safety Study of Tacrolimus Ointment in Adult Participants With Atopic Dermatitis Completed NCT01828879 Phase 4 Tacrolimus
8 An Efficacy and Safety Study of Tacrolimus Ointment in Pediatric Participants With Atopic Dermatitis Completed NCT01782729 Phase 4 Tacrolimus
9 Effects of Pimecrolimus Cream 1% on the Molecular and Cellular Profile of Adult Male Patients With Atopic Dermatitis Completed NCT00117377 Phase 4 Pimecrolimus;Placebo
10 A Study Evaluating the Efficacy of Fluocinonide Cream 0.1% (Vanos) in Subjects With Atopic Dermatitis Completed NCT01049243 Phase 4 Fluocinonide Cream 0.1%
11 Open Label Study of Long Term Treatment of Pediatric Treatment of Atopic Dermatitis With Pimecrolimus Cream 1% Within a Usual Clinical Setting Completed NCT00509990 Phase 4 Pimecrolimus
12 A Comparison Study Between Protopic (Tacrolimus) Ointment and Elidel (Pimecrolimus) Cream in Treating Subjects With Atopic Dermatitis Completed NCT00666302 Phase 4 tacrolimus ointment;pimecrolimus cream
13 Comparison Study Between Protopic (Tacrolimus Ointment) and Elidel (Pimecrolimus Cream) in Treating Pediatric Patients With Atopic Dermatitis Completed NCT00666159 Phase 4 tacrolimus ointment;pimecrolimus cream
14 Comparison Study Between Protopic (Tacrolimus Ointment) and Elidel (Pimecrolimus Cream) in Pediatric Patients With Mild Atopic Dermatitis Completed NCT00667160 Phase 4 tacrolimus ointment;pimecrolimus cream
15 Evaluation of Cetaphil Advanced Usage to Control Light to Moderate Atopic Dermatitis, in Attempt to Reduce the Necessity of Topic Corticoids Application Completed NCT01063218 Phase 4
16 Comparison of Pimecrolimus Cream 1% Twice-Daily to Once-Daily Dosing in the Management of Atopic Dermatitis in Pediatric Subjects Completed NCT00139581 Phase 4 Pimecrolimus;Pimecrolimus
17 Pimecrolimus Cream 1% Plus Topical Corticosteroid in Patients (2-17 Years of Age) With Severe Atopic Dermatitis Completed NCT00121381 Phase 4 Pimecrolimus plus topical corticosteroid (TCS);Pimecrolimus vehicle (Placebo) plus topical corticosteroid (TCS)
18 Study to Evaluate the Safety and Efficacy of Alefacept (Amevive) in Subjects With Moderate to Severe Atopic Dermatitis Completed NCT00832585 Phase 4 Alefacept
19 Adherence to Topical Hydrocortisone 17-butyrate 0.1% (Locoid®) Using Different Vehicles in Adults With Atopic Dermatitis Completed NCT00693693 Phase 4 hydrocortisone 17-butyrate 0.1% Cream preparation;hydrocortisone 17-butyrate 0.1% Ointment preparation;hydrocortisone 17-butyrate 0.1% Lipocream preparation
20 Protopic Ointment in Children Atopic Eczema Completed NCT00689832 Phase 4 Tacrolimus 0.03%;Fluticasone 0.005%
21 Evaluating Treatment Resistant Dermatitis TaroIIR Completed NCT03050294 Phase 4 Desoximetasone 0.25% spray
22 Protopic Ointment in Adult Atopic Eczema of the Face Completed NCT00690105 Phase 4 tacrolimus 0.1%;fluticasone 0.005 %
23 Efficacy Study of Montelukast in Atopic Dermatitis Induced by Food Allergens Completed NCT00557284 Phase 4 Montelukast;Placebo
24 Analysis of the Quality of Life, the Clinical Effectiveness and Cost-effectiveness of a Novel Educational Programme in Patients With Psoriasis and Atopic Dermatitis Completed NCT01077882 Phase 4
25 Locobase® REPAIR Used as an Adjunctive to Standard Therapy in Children With Moderate to Severe Atopic Dermatitis Completed NCT00673725 Phase 4 Locobase® REPAIR
26 A Clinical Study in Children and Adolescents With Mild to Moderate Atopic Dermatitis Completed NCT00568412 Phase 4 Elidel
27 Measuring Adherence to Topical Therapy in Children With Atopic Dermatitis and the Impact of a Return Visit Completed NCT00654355 Phase 4 tacrolimus ointment
28 Elidel-Study: Elidel in Patients With Atopic Dermatitis Completed NCT00180141 Phase 4 Elidel-Creme
29 Pimecrolimus Cream 1% (Elidel®) and Medicated Device Cream (EletoneTM) in the Treatment and Maintenance of Atopic Dermatitis. Completed NCT01177566 Phase 4 pimecrolimus
30 Efficacy of Desonide (Desonatetm) Gel 0.05% in Younger and Older Subjects With Atopic Dermatitis Completed NCT00690833 Phase 4 topical desonide hydrogel 0.05%
31 A Multi-Center Study of Short and Long-term Use of Protopic Ointment in Patients With Atopic Dermatitis Completed NCT00106496 Phase 4 Protopic;Corticosteroid;placebo
32 Reconstitution With Pimecrolimus Cream 1% of Steroid-damaged Skin in Adults With Atopic Dermatitis Completed NCT00367393 Phase 4 Pimecrolimus cream 1%
33 Epiceram™ Device Versus Mid-Strength Topical Steroid (Fluticasone Propionate 0.05%) for Treatment of Atopic Dermatitis Completed NCT00616538 Phase 4 Fluticasone Propionate 0.05%
34 Combination Therapy for Atopic Dermatitis Completed NCT00119158 Phase 4 Combination of pimecrolimus and fluticasone;pimecrolimus
35 Management of Pruritus With Xyzal in Atopic Dermatitis Completed NCT00884325 Phase 4 Levocetirizine dihydrochloride (Xyzal);placebo
36 Efficacy and Safety Study of Advantan for Maintenance Treatment of Atopic Dermatitis Completed NCT00185510 Phase 4 Methylprednisolone Aceponate (Advantan, BAY86-4862);Placebo
37 A Study to Determine Serum and Skin Biopsy Biomarkers in Patients Receiving Topical Corticosteroid (TCS) and Following TCS Withdrawal Completed NCT02317276 Phase 4 Triamcinolone 0.1%
38 Trial on Effectiveness Combined Probiotics in Atopic Dermatitis in Children Completed NCT02519556 Phase 4 Probiatop;Placebo
39 Epiceram Versus Elidel for Treatment of Mild to Moderate Atopic Dermatitis Completed NCT00460083 Phase 4 Elidel(R) (pimecrolimus 1%)
40 A Quality of Life and Safety Study With Pimecrolimus Cream, 1% in Children (Age 2-12 Years) With Atopic Dermatitis Completed NCT00484003 Phase 4 Pimecrolimus cream 1%
41 Prednisolone vs. Ciclosporine in Severe Atopic Eczema Completed NCT00445081 Phase 4 Prednisolone;Ciclosporine A
42 Efficacy and Safety of Pimecrolimus Cream 1% in Patients (2 to 11 Years Old) With Mild to Moderate Facial Atopic Dermatitis Completed NCT00130364 Phase 4 Pimecrolimus;Placebo
43 Cetaphil Restoraderm Effect on Young Children With Atopic Dermatitis Completed NCT02589392 Phase 4
44 Open-label Study to Investigate Systemic Exposure in Adult and Pediatric Atopic Dermatitis Patients Treated 8.5 Days With Pimecrolimus Cream 1% Under Occlusion Completed NCT00925730 Phase 4 Pimecrolimus
45 Study to Determine the Effect of an Anti-IgE Agent on Inflammatory Cells in the Skin of Atopic Dermatitis Patients Completed NCT00822783 Phase 4 Omalizumab;Placebo
46 A Study to Investigate the Use of Hydrogel Vehicle in Maintaining the Skin Barrier in Persons With Atopic Dermatitis Completed NCT01065714 Phase 4 Hydrogel vehicle;Eucerin Lotion
47 Preventive Treatment of Tacrolimus Ointment in Children With Atopic Dermatitis Completed NCT01745159 Phase 4 tacrolimus
48 Effect of Moisturising Creams on Skin Moisture in Atopic Dermatitis Completed NCT00846235 Phase 4
49 Comparison of the Efficacy and Safety of Two Topical Creams for Pediatric Atopic Dermatitis Completed NCT00828412 Phase 4 Desonide Cream 0.05%
50 Safety and Efficacy of Pimecrolimus Cream 1% in Mild to Moderate Head and Neck Atopic Dermatitis (AD) Patients Completed NCT00121316 Phase 4 Pimecrolimus;Placebo

Search NIH Clinical Center for Dermatitis, Atopic

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: dermatitis, atopic

Genetic Tests for Dermatitis, Atopic

Genetic tests related to Dermatitis, Atopic:

# Genetic test Affiliating Genes
1 Dermatitis, Atopic 29

Anatomical Context for Dermatitis, Atopic

The Foundational Model of Anatomy Ontology organs/tissues related to Dermatitis, Atopic:

19
The Skin

MalaCards organs/tissues related to Dermatitis, Atopic:

41
Skin, Testes, T Cells, Colon, Breast, Monocytes, Thymus

Publications for Dermatitis, Atopic

Articles related to Dermatitis, Atopic:

(show top 50) (show all 2726)
# Title Authors Year
1
Alopecia areata after dupilumab for atopic dermatitis. ( 29387767 )
2018
2
The Genetics of Chronic Itch: Gene Expression in the Skin of Patients with Atopic Dermatitis and Psoriasis with SevereA Itch. ( 29317264 )
2018
3
Could conjunctivitis in dupilumab treated atopic dermatitis patients be caused by colonization with Demodex and increased IL-17 levels? Reply from authors. ( 29336016 )
2018
4
Increased interleukin-36I^ expression in skin and sera of patients with atopic dermatitis and mycosis fungoides/SAczary syndrome. ( 29314201 )
2018
5
A 8-year population-based cohort study of irritable bowel syndrome in childhood with history of atopic dermatitis. ( 29374025 )
2018
6
Validation of patient-reported global severity of atopic dermatitis in adults. ( 28905999 )
2018
7
Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances and childhood atopic dermatitis: a prospective birth cohort study. ( 29343261 )
2018
8
Identification and interaction analysis of key genes and microRNAs in atopic dermatitis by bioinformatics analysis. ( 29974487 )
2018
9
Exploring Immune Development in Infants With Moderate to Severe Atopic Dermatitis. ( 29966024 )
2018
10
Cardiovascular disease and atopic dermatitis: epidemiological strengths and limitations. ( 29971775 )
2018
11
Breast abscess caused by <i>Staphylococcus aureus</i> in 2 adolescent girls with atopic dermatitis. ( 29963104 )
2018
12
An approach on the potential use of probiotics in the treatment of skin conditions: acne and atopic dermatitis. ( 29676446 )
2018
13
IgE-expressing memory B cells and plasmablasts are increased in blood of children with asthma, food allergy and atopic dermatitis. ( 29380876 )
2018
14
Impact of dupilumab on health-related quality of life in patients with atopic dermatitis. ( 29441557 )
2018
15
Enolase-1 expression in the stratum corneum is elevated with parakeratosis of atopic dermatitis and disrupts the cellular tight junction barrier in keratinocytes. ( 29430682 )
2018
16
Fecal Microbiome and Food Allergy in Pediatric Atopic Dermatitis: A Cross-Sectional Pilot Study. ( 29393195 )
2018
17
Online education improves pediatric residents' understanding of atopic dermatitis. ( 29193379 )
2018
18
Cause-specific mortality in adults with atopic dermatitis. ( 29102489 )
2018
19
Atopic dermatitis in Chinese patients shows T<sub>H</sub>2/T<sub>H</sub>17-skewing with psoriasiform features. ( 29964056 )
2018
20
JAK inhibitors appear to have a bright future in the treatment of atopic dermatitis. ( 29441552 )
2018
21
Duration of topical therapy in the maintenance of atopic dermatitis remission in paediatric age. ( 29968448 )
2018
22
Cytokine Targeted Therapeutics forA Alopecia Areata: Lessons fromA Atopic Dermatitis and OtherA Inflammatory Skin Diseases. ( 29273110 )
2018
23
Conjunctivitis Occurring in Atopic Dermatitis Patients Treated with Dupilumab - Clinical Characteristics and Treatment. ( 29432961 )
2018
24
Comparison of topical tofacitinib and 0.1% hypochlorous acid in a murine atopic dermatitis model. ( 29970189 )
2018
25
Microbiome analysis of forehead skin in patients with atopic dermatitis and healthy subjects: Implication of Staphylococcus and Corynebacterium. ( 29971837 )
2018
26
Case of atopic dermatitis concurrent with idiopathic thrombocytopenic purpura, whose serum thymus and activation-regulated chemokine level remained undetectable. ( 29399856 )
2018
27
Substance P restores normal skin architecture and reduces epidermal infiltration of sensory nerve fiber in TNCB-induced atopic dermatitis-like lesions in NC/Nga mice. ( 29269174 )
2018
28
Eyelash length for the diagnosis of atopic dermatitis and ichthyosis vulgaris in children-a case control study. ( 29675643 )
2018
29
Serum levels of squamous cell carcinoma antigens 1 and 2 reflect disease severity and clinical type of atopic dermatitis in adult patients. ( 28734739 )
2018
30
Atopic dermatitis: the skin barrier and beyond. ( 29969827 )
2018
31
Lymphopenia in atopic dermatitis patients treated with oral immunosuppressive drugs. ( 29526121 )
2018
32
Eosinophils determine dermal thickening and water loss in a MC903 model of atopic dermatitis. ( 29964034 )
2018
33
Stand-alone Emollient Treatment Reduces Flares After Discontinuation of Topical Steroid Treatment in Atopic Dermatitis: A Double-blind, Randomized, Vehicle-controlled, Left-right Comparison Study. ( 29335742 )
2018
34
Very early introduction of semisolid foods in preterm infants does not increase food allergies or atopic dermatitis. ( 29981439 )
2018
35
Drug survival and post-drug survival of first-line immunosuppressive treatments for atopic dermatitis: comparison between methotrexate and cyclosporine. ( 29444359 )
2018
36
Atopic dermatitis yardstick: Practical recommendations for an evolving therapeutic landscape. ( 29273118 )
2018
37
Juniperus chinensis Fruits Attenuate Oxazolone- and 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis Symptoms in Mice. ( 29386485 )
2018
38
A cross-sectional study of YouTube videos about atopic dermatitis. ( 29447681 )
2018
39
Is atopic dermatitis associated with obesity? A systematic review of observational studies. ( 29444366 )
2018
40
Altered lipid properties of the stratum corneum in Canine Atopic Dermatitis. ( 29175102 )
2018
41
A case of atopic dermatitis caused by <i>Ascaris lumbricoides</i> infection. ( 29651227 )
2018
42
Ultraviolet A Eye Irradiation Ameliorates Atopic Dermatitis via p53 and Clock Gene Proteins in NC/Nga Mice. ( 29105092 )
2018
43
Association of Inadequately Controlled Disease and Disease Severity With Patient-Reported Disease Burden in Adults With Atopic Dermatitis. ( 29971354 )
2018
44
Activity During Sleep Measured by a Sheet-Shaped Body Vibrometer and the Severity of Atopic Dermatitis in Adults: A Comparison With Wrist Actigraphy. ( 29351828 )
2018
45
Atopic dermatitis complicated by severe impetigo in a Syrian refugee infant. ( 29764821 )
2018
46
Phenotype, Function, and Mobilization of 6-Sulfo LacNAc-Expressing Monocytes in Atopic Dermatitis. ( 29977237 )
2018
47
Antioxidative Phytochemicals Accelerate Epidermal Terminal Differentiation via the AHR-OVOL1 Pathway: Implications for Atopic Dermatitis. ( 29972223 )
2018
48
Signs of atopic dermatitis and contact dermatitis affected by distinct H2-haplotype in the NC/Nga genetic background. ( 29416104 )
2018
49
Could conjunctivitis in dupilumab treated atopic dermatitis patients be caused by colonization with demodex and increased IL-17 levels? ( 29333603 )
2018
50
Impact of Food Allergy on the Growth of Children with Moderate-Severe Atopic Dermatitis. ( 29378286 )
2018

Variations for Dermatitis, Atopic

ClinVar genetic disease variations for Dermatitis, Atopic:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 KCNJ11 NM_000525.3(KCNJ11): c.185C> G (p.Thr62Arg) single nucleotide variant Likely pathogenic rs1057518775 GRCh38 Chromosome 11, 17387907: 17387907
2 KCNJ11 NM_000525.3(KCNJ11): c.185C> G (p.Thr62Arg) single nucleotide variant Likely pathogenic rs1057518775 GRCh37 Chromosome 11, 17409454: 17409454
3 CYP4F22 NM_173483.3(CYP4F22): c.1211T> C (p.Leu404Pro) single nucleotide variant Uncertain significance GRCh38 Chromosome 19, 15548182: 15548182
4 CYP4F22 NM_173483.3(CYP4F22): c.1211T> C (p.Leu404Pro) single nucleotide variant Uncertain significance GRCh37 Chromosome 19, 15658993: 15658993
5 CYP4F22 NM_173483.3(CYP4F22): c.1544G> T (p.Arg515Leu) single nucleotide variant Uncertain significance GRCh38 Chromosome 19, 15551419: 15551419
6 CYP4F22 NM_173483.3(CYP4F22): c.1544G> T (p.Arg515Leu) single nucleotide variant Uncertain significance GRCh37 Chromosome 19, 15662230: 15662230

Expression for Dermatitis, Atopic

Search GEO for disease gene expression data for Dermatitis, Atopic.

Pathways for Dermatitis, Atopic

Pathways related to Dermatitis, Atopic according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.71 IFNG IL13 IL4 IL5 MS4A2 RNASE3
2
Show member pathways
12.47 IFNG IL13 IL4 IL5 TSLP
3
Show member pathways
12.42 IL13 IL4 IL5 MS4A2
4
Show member pathways
12.28 IFNG IL13 IL4 IL5
5
Show member pathways
12.16 CCL17 IFNG IL13 IL4 IL5
6
Show member pathways
11.86 CCL17 CCL22 IFNG IL13 IL4 IL5
7 11.82 IFNG IL4 IL5
8 11.8 CCL22 IL13 IL4
9 11.62 IFNG IL13 IL4 IL5
10
Show member pathways
11.6 IFNG IL4 IL5
11 11.51 CCL17 IL4 IL5
12 11.5 IL13 IL4 IL5
13 11.46 IFNG IL13 IL4 IL5 TSLP
14 11.38 CCL22 IL13 IL4
15 11.15 IFNG IL4 IL5
16 11.1 IFNG IL13 IL4 IL5
17 10.97 IFNG IL13 IL4 IL5
18 10.86 IFNG IL13 IL4 IL5 TSLP
19 10.83 CCL17 CCL22 IFNG IL13 IL31 IL4

GO Terms for Dermatitis, Atopic

Cellular components related to Dermatitis, Atopic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 CCL17 CCL22 IFNG IL13 IL31 IL4
2 extracellular space GO:0005615 9.32 CCL17 CCL22 IFNG IL13 IL31 IL4

Biological processes related to Dermatitis, Atopic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.77 CCL17 CCL22 IL13 IL5 MS4A2
2 cytokine-mediated signaling pathway GO:0019221 9.65 CCL22 IL13 IL31 IL4 IL5
3 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.58 IFNG IL13 TSLP
4 positive regulation of B cell proliferation GO:0030890 9.5 IL13 IL4 IL5
5 immune response GO:0006955 9.5 CCL17 CCL22 IFNG IL13 IL4 IL5
6 positive regulation of macrophage activation GO:0043032 9.46 IL13 MIR155
7 positive regulation of interleukin-13 production GO:0032736 9.43 IL4 TSLP
8 regulation of signaling receptor activity GO:0010469 9.23 CCL17 CCL22 IFNG IL13 IL31 IL4
9 negative regulation of complement-dependent cytotoxicity GO:1903660 9.16 IL13 IL4

Molecular functions related to Dermatitis, Atopic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.23 CCL17 CCL22 IFNG IL13 IL31 IL4
2 cytokine receptor binding GO:0005126 9.13 IL13 IL31 IL4

Sources for Dermatitis, Atopic

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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