ATOD
MCID: DRM053
MIFTS: 68

Dermatitis, Atopic (ATOD)

Categories: Genetic diseases, Immune diseases, Neuronal diseases, Skin diseases

Aliases & Classifications for Dermatitis, Atopic

MalaCards integrated aliases for Dermatitis, Atopic:

Name: Dermatitis, Atopic 57 44 40 72
Atopic Dermatitis 12 75 25 37 6 15 33
Atopic Eczema 12 25 15 17
Dermatitis, Atopic, Susceptibility to, 1 57 29 13
Atopic Neurodermatitis 12
Dermatitis, Atopic 1 57
Allergic Dermatitis 12
Besnier's Prurigo 12
Dermatitis Atopic 55
Eczema, Atopic 57
Eczema 72
Atod 57

Characteristics:

OMIM:

57
Miscellaneous:
food intolerance
diagnosis requires 3 major features (a positive family history is also considered a major feature) and at least 3 minor features

Inheritance:
autosomal dominant


HPO:

32
dermatitis, atopic:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:3310
KEGG 37 H01358
MeSH 44 D003876
SNOMED-CT 68 24079001
MedGen 42 C0011615
UMLS 72 C0011615 C0013595

Summaries for Dermatitis, Atopic

Genetics Home Reference : 25 Atopic dermatitis (also known as atopic eczema) is a disorder characterized by inflammation of the skin (dermatitis). The condition usually begins in early infancy, and it often disappears before adolescence. However, in some affected individuals the condition continues into adulthood; in others, it does not begin until adulthood. Hallmarks of atopic dermatitis include dry, itchy skin and red rashes that come and go. The rashes can occur on any part of the body, although the pattern tends to be different at different ages. In affected infants, the rashes commonly occur on the face, scalp, hands, and feet. In children, the rashes are usually found in the bend of the elbows and knees and on the front of the neck. In adolescents and adults, the rashes typically occur on the wrists, ankles, and eyelids in addition to the bend of the elbows and knees. Scratching the itchy skin can lead to oozing and crusting of the rashes and thickening and hardening (lichenification) of the skin. The itchiness can be so severe as to disturb sleep and impair a person's quality of life. The word "atopic" indicates an association with allergies. While atopic dermatitis is not always due to an allergic reaction, it is commonly associated with other allergic disorders: up to 60 percent of people with atopic dermatitis develop asthma or hay fever (allergic rhinitis) later in life, and up to 30 percent have food allergies. Atopic dermatitis is often the beginning of a series of allergic disorders, referred to as the "atopic march." Development of these disorders typically follows a pattern, beginning with atopic dermatitis, followed by food allergies, then hay fever, and finally asthma. However, not all individuals with atopic dermatitis will progress through the atopic march, and not all individuals with one allergic disease will develop others. Individuals with atopic dermatitis have an increased risk of developing other conditions related to inflammation, such as inflammatory bowel disease, rheumatoid arthritis, and hair loss caused by a malfunctioning immune reaction (alopecia areata). They also have an increased risk of having a behavioral or psychiatric disorder, such as attention-deficit/hyperactivity disorder (ADHD) or depression. In a particular subset of individuals with atopic dermatitis, the immune system is unable to protect the body from foreign invaders such as bacteria and fungi (which is known as immunodeficiency). These individuals are prone to recurrent infections. Most also have other allergic disorders, such as asthma, hay fever, and food allergies. Atopic dermatitis can also be a feature of separate disorders that have a number of signs and symptoms, which can include skin abnormalities and immunodeficiency. Some such disorders are Netherton syndrome; immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome; and severe dermatitis, multiple allergies, metabolic wasting (SAM) syndrome.

MalaCards based summary : Dermatitis, Atopic, also known as atopic dermatitis, is related to dermatitis, atopic, 3 and asthma, and has symptoms including pruritus and exanthema. An important gene associated with Dermatitis, Atopic is FLG (Filaggrin), and among its related pathways/superpathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. The drugs Clobetasol and Glycerol have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and t cells, and related phenotypes are cataract and ichthyosis

Disease Ontology : 12 A dermatitis that is a chronically relapsing inflammatory allergic response located in the skin that causes itching and flaking.

OMIM : 57 Atopic dermatitis (ATOD), also known as eczema, is a common chronic pruritic inflammatory skin disease with a strong genetic component. Onset typically occurs during the first 2 years of life (review by Soderhall et al., 2007). (603165)

KEGG : 37
Atopic dermatitis (AD) is a relapsing chronic inflammatory skin disease characterized by eczematous skin lesions and intense pruritus. A genetic defect in the filaggrin (FLG) protein and/or environmental factors are thought to cause AD by disrupting the epidermis. This disruption, in turn, results in contact between immune cells in the dermis and antigens from the external environment leading to intense itching, scratching, and inflammation. Apart from FLG, recent genome-wide association studies (GWASs) have identified many susceptibility loci of atopic dermatitis with genome-wide significance.

Wikipedia : 75 Atopic dermatitis (AD), also known as atopic eczema, is a type of inflammation of the skin (dermatitis).... more...

Related Diseases for Dermatitis, Atopic

Diseases in the Dermatitis, Atopic family:

Dermatitis, Atopic, 2 Dermatitis, Atopic, 3
Dermatitis, Atopic, 4 Dermatitis, Atopic, 5
Dermatitis, Atopic, 6 Dermatitis, Atopic, 7
Dermatitis, Atopic, 8 Dermatitis, Atopic, 9

Diseases related to Dermatitis, Atopic via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 774)
# Related Disease Score Top Affiliating Genes
1 dermatitis, atopic, 3 35.4 FLG ATOD3
2 asthma 34.2 TSLP RNASE3 IL5 IL4R IL4 IL31
3 milk allergy 34.1 RNASE3 IL5 IL4
4 egg allergy 34.0 IL5 IL4
5 dermatitis 33.5 TSLP IL5 IL4 IL31 IL13 FLG
6 eczema herpeticum 33.2 TSLP FLG
7 skin disease 32.8 RNASE3 IL5 IL4 IL31 IL13 FLG
8 allergic conjunctivitis 32.5 RNASE3 IL5 IL4 IL13
9 rhinitis 32.5 RNASE3 IL5 IL4R IL4 IL13
10 allergic rhinitis 32.4 RNASE3 IL5 IL4R IL4 IL13
11 contact dermatitis 32.3 IL5 IL4 IL31 FLG CCL17
12 food allergy 32.3 RNASE3 IL5 IL4 IL13 FLG
13 allergic contact dermatitis 32.2 IL5 IL4 IL31 FLG CCL17
14 tetanus 32.1 IL5 IL4 IL13
15 allergic hypersensitivity disease 32.1 TSLP RNASE3 IL5 IL4R IL4 IL13
16 hypereosinophilic syndrome 32.1 RNASE3 IL5 IL4 IL13 CCL17
17 atopic keratoconjunctivitis 32.0 RNASE3 IL5 IL4
18 blepharoconjunctivitis 32.0 RNASE3 IL4 CMA1
19 bronchiolitis 31.9 RNASE3 IL5 IL4R IL4 IL13
20 pollen allergy 31.9 RNASE3 IL5 IL4R IL13
21 latex allergy 31.9 RNASE3 IL5 IL4 IL13 FLG
22 ascaris lumbricoides infection 31.9 TSLP IL5 IL13
23 ige responsiveness, atopic 31.9 RNASE3 IL5 IL4R IL4 IL13
24 respiratory allergy 31.8 TSLP RNASE3 IL5 IL4R IL4 IL13
25 urticaria 31.7 RNASE3 FCER2 CMA1
26 cow milk allergy 31.7 RNASE3 IL5
27 keratoconjunctivitis 31.7 RNASE3 IL5 IL4 IL13 CCL17
28 vernal keratoconjunctivitis 31.7 RNASE3 IL5 IL4 IL13
29 schistosomiasis 31.7 RNASE3 IL5 IL4 IL13
30 cytokine deficiency 31.7 IL5 IL13
31 conjunctival disease 31.7 RNASE3 IL5 IL4 IL13
32 onchocerciasis 31.7 RNASE3 IL5 IL4 IL13
33 allergic asthma 31.7 TSLP RNASE3 IL5 IL4R IL4 IL13
34 chronic conjunctivitis 31.7 TSLP RNASE3 IL5 IL4 IL13 FCER2
35 parasitic helminthiasis infectious disease 31.7 RNASE3 IL5 IL4 IL13
36 gastroenteritis 31.7 TSLP RNASE3 IL5 IL4
37 proteasome-associated autoinflammatory syndrome 1 31.7 RNASE3 IL5 IL4 IL13
38 peanut allergy 31.7 IL13 FLG CCL17
39 aspergillosis 31.6 IL5 IL4 CCL17
40 common cold 31.6 TSLP RNASE3 IL5 IL13
41 cutaneous leishmaniasis 31.6 IL5 IL4 IL13 FCER2
42 conjunctivitis 31.5 RNASE3 IL5 IL4 IL13
43 leishmaniasis 31.5 IL5 IL4 IL13
44 nickel allergic contact dermatitis 31.5 IL5 IL4 IL13
45 esophagitis, eosinophilic, 1 31.4 TSLP IL5 IL13
46 eosinophilic gastroenteritis 31.4 TSLP RNASE3 IL5
47 esophagitis 31.4 TSLP IL5 IL13
48 allergic bronchopulmonary aspergillosis 31.4 IL5 IL4 CCL17
49 drug allergy 31.4 IL5 IL4R
50 stevens-johnson syndrome/toxic epidermal necrolysis 31.4 IL5 IL13 CCL17

Graphical network of the top 20 diseases related to Dermatitis, Atopic:



Diseases related to Dermatitis, Atopic

Symptoms & Phenotypes for Dermatitis, Atopic

Human phenotypes related to Dermatitis, Atopic:

32 (show all 18)
# Description HPO Frequency HPO Source Accession
1 cataract 32 HP:0000518
2 ichthyosis 32 HP:0008064
3 abnormality of metabolism/homeostasis 32 HP:0001939
4 pallor 32 HP:0000980
5 pruritus 32 HP:0000989
6 dry skin 32 HP:0000958
7 asthma 32 HP:0002099
8 conjunctivitis 32 HP:0000509
9 eczema 32 HP:0000964
10 keratoconus 32 HP:0000563
11 recurrent skin infections 32 HP:0001581
12 allergic rhinitis 32 HP:0003193
13 atopic dermatitis 32 HP:0001047
14 food intolerance 32 HP:0012537
15 infra-orbital fold 32 HP:0011232
16 facial erythema 32 HP:0001041
17 keratosis pilaris 32 HP:0032152
18 flexural lichenification 32 HP:0007453

Symptoms via clinical synopsis from OMIM:

57
Skin Nails Hair Skin:
ichthyosis
facial erythema
keratosis pilaris
xerosis
pruritus (major feature)
more
Head And Neck Nose:
allergic rhinitis

Immunology:
elevated ige

Head And Neck Eyes:
keratoconus
cataracts (anterior- subcapsular)
conjunctivitis (recurrent)
orbital darkening

Respiratory Airways:
bronchial asthma

Laboratory Abnormalities:
immediate (type i) skin test reactivity

Clinical features from OMIM:

603165

UMLS symptoms related to Dermatitis, Atopic:


pruritus, exanthema

MGI Mouse Phenotypes related to Dermatitis, Atopic:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.17 FCER2 IL13 IL4 IL4R IL5 STAT1

Drugs & Therapeutics for Dermatitis, Atopic

Drugs for Dermatitis, Atopic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 465)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clobetasol Approved, Experimental, Investigational Phase 4 25122-46-7, 25122-41-2 32798 5311051
2
Glycerol Approved, Investigational Phase 4 56-81-5 753
3
Mineral oil Approved, Vet_approved Phase 4 8042-47-5
4
Bacitracin Approved, Vet_approved Phase 4 1405-87-4 439542 10909430
5 Parthenolide Approved, Investigational Phase 4 20554-84-1
6
Bronopol Approved Phase 4 52-51-7
7
Cetirizine Approved Phase 4 83881-51-0 2678
8
Petrolatum Approved, Investigational Phase 4 8009-03-8
9
carbamide peroxide Approved Phase 4 124-43-6
10
Fluticasone Approved, Experimental Phase 4 90566-53-3 62924
11
Montelukast Approved Phase 4 158966-92-8 5281040
12
Fluocinonide Approved, Investigational Phase 4 356-12-7 9642
13
Levocetirizine Approved Phase 4 130018-77-8 1549000
14
Desoximetasone Approved Phase 4 382-67-2 5311067
15
mometasone furoate Approved, Investigational, Vet_approved Phase 4 83919-23-7
16
Promethazine Approved, Investigational Phase 4 60-87-7 4927
17
Diphenhydramine Approved, Investigational Phase 4 58-73-1, 147-24-0 3100
18
Mupirocin Approved, Investigational, Vet_approved Phase 4 12650-69-0 446596
19
Triclosan Approved, Investigational Phase 4 3380-34-5 5564
20
Glucosamine Approved, Investigational Phase 4 3416-24-8 439213
21
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
22
Doxepin Approved, Investigational Phase 4 1668-19-5 667477 667468
23
Loteprednol Approved, Experimental Phase 4 129260-79-3, 82034-46-6 444025 9865442
24
Tobramycin Approved, Investigational Phase 4 32986-56-4 36294 5496
25
Omalizumab Approved, Investigational Phase 4 242138-07-4
26
tannic acid Approved Phase 4 1401-55-4
27
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
28
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
29
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
30
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
31
Coal tar Approved Phase 4 8007-45-2
32
Zinc Approved, Investigational Phase 4 7440-66-6 32051
33
Zinc oxide Approved Phase 4 1314-13-2
34
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
35
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
36
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
37
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
38
Methylprednisolone aceponate Approved, Vet_approved Phase 4 86401-95-8
39
Ustekinumab Approved, Investigational Phase 4 815610-63-0
40
Bleomycin Approved, Investigational Phase 4 11056-06-7 5360373
41 Vedolizumab Approved Phase 4 943609-66-3
42
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
43
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
44
Alitretinoin Approved, Investigational Phase 4 5300-03-8 444795 449171
45
Clotrimazole Approved, Vet_approved Phase 4 23593-75-1 2812
46
Salicylic acid Approved, Investigational, Vet_approved Phase 4 69-72-7 338
47
Calcitriol Approved, Nutraceutical Phase 4 32222-06-3 5280453 134070
48
Enoxolone Investigational Phase 4 471-53-4 18526330
49
Cortisone Experimental Phase 4 53-06-5 222786
50
Chitosan Experimental Phase 4 9012-76-4 71853

Interventional clinical trials:

(show top 50) (show all 1064)
# Name Status NCT ID Phase Drugs
1 Effect of Moisturizing Creams on Skin Barrier Function Unknown status NCT00771121 Phase 4 urea/lactic acid;Placebo
2 Efficacy of KAM2904 Face Cream and KAM3008 Body Lotion Treatment in Children With Atopic Dermatitis (AD) Unknown status NCT01781663 Phase 4
3 Bronchiolitis All-study, SE-Norway What is the Optimal Inhalation Treatment for Children 0-12 Months With Acute Bronchiolitis? Unknown status NCT00817466 Phase 4 Racemic adrenaline;Isotonic saline
4 A Randomized, Double-blind, Placebo-controlled, Multi-center Clinical Trials to Evaluate the Efficacy and Safety of Runzao Zhiyang Capsule in Treating Chronic Eczema Unknown status NCT02601222 Phase 4 Runzao zhiyang capsule;Runzaozhiyang capsule agent simulation;Urea cream
5 Clinical Evaluation of T.R.U.E. Test Panel 3.2 in Children and Adolescents (PREA II) Unknown status NCT01797562 Phase 4 T.R.U.E. Test Panel 3.2
6 The Randomized Controlled Clinical Trial of Kushen Injection Reducing Radiotherapy Related Adverse Reactions in Lung Cancer Unknown status NCT02346318 Phase 4 Compound Kushen Injection
7 Comparing Treatment Efficacy With High and Medium Dose of Fluticasone in Combination With Salmeterol in COPD Patients Unknown status NCT01657487 Phase 4 Fluticasone/Salmeterol high dose
8 Comparison of Efficacy of Glycerol, Two Topical Steroids, and a Topical Immune Modulator Against Experimentally Induced Skin Irritation Unknown status NCT00779792 Phase 4 clobetasol;triamcinolone acetonide;tacrolimus;glycerol;vehicle ointment (paraffin oil/soft white paraffin)
9 Efficacy of Systemic Glucocorticoid in the Treatment of Wheezing in Children Unknown status NCT00494624 Phase 4 prednisolone
10 Prednisolone vs. Ciclosporine in Severe Atopic Eczema Completed NCT00445081 Phase 4 Prednisolone;Ciclosporine A
11 A 3-Month Open Label, National, Quality of Life , and Safety Study With Pimecrolimus Cream, 1% in Children (Age 2-12 Years ) With Atopic Dermatitis Completed NCT00484003 Phase 4 Pimecrolimus cream 1%
12 A Multi-Center Study to Assess the Impact of Topical Corticosteroids on the Safety and Efficacy of Protopic Ointment in the Short-Term Treatment of Atopic Dermatitis and to Assess Protopic in the Long-term Management of Atopic Dermatitis Completed NCT00106496 Phase 4 Protopic;Corticosteroid;placebo
13 A Randomized, Investigator Blinded Study of Protopic (Tacrolimus) Ointment Vs. Elidel (Pimecrolimus) Cream in Patients With Atopic Dermatitis Completed NCT00666302 Phase 4 tacrolimus ointment;pimecrolimus cream
14 A Phase IV,Open Label Study of the Treatment of Children With Moderate to Severe Atopic Dermatitis (AD) Using Locobase® REPAIR as an Adjunctive to Standard Treatment Completed NCT00673725 Phase 4 Locobase® REPAIR
15 Non-comparative Open-label Study to Investigate the Efficacy, Safety and Systemic Exposure of Pimecrolimus in Adult and Pediatric Patients With Moderate to Severe Atopic Dermatitis Treated Topically for 8.5 Days With Pimecrolimus Cream 1% Under Occlusion Completed NCT00925730 Phase 4 Pimecrolimus
16 The Role of Anti-IgE (Omalizumab) in the Management of Severe Recalcitrant Paediatric Atopic Eczema Completed NCT02300701 Phase 4 Xolair;Placebo
17 Effects of Pimecrolimus Cream 1% on the Molecular and Cellular Profile of Adult Male Patients With Atopic Dermatitis Completed NCT00117377 Phase 4 Pimecrolimus;Placebo
18 Control of Therapy With Elidel vs Placebo in Patients With Atopic Dermatitis Using Bioengineering Methods Completed NCT00180141 Phase 4 Elidel-Creme
19 Open Label Multicenter Study, 52 Weeks Duration, Using Pimecrolimus Cream 1% for the Long-term Treatment of Mild to Moderate Atopic Dermatitis in Pediatric Patients Within a Usual Clinical Setting Completed NCT00509990 Phase 4 Pimecrolimus
20 A Randomized, Investigator Blinded Study of Protopic (Tacrolimus) Ointment Vs. Elidel (Pimecrolimus) Cream in Pediatric Patients With Moderate to Severe Atopic Dermatitis Completed NCT00666159 Phase 4 tacrolimus ointment;pimecrolimus cream
21 Measuring Adherence to Topical Therapy in Children With Atopic Dermatitis and the Impact of a Return Visit Completed NCT00654355 Phase 4 tacrolimus ointment
22 A Multicenter, 3-week, Randomized, Double-blind, Parallel-group, Vehicle-controlled Study to Evaluate the Efficacy and Safety of Pimecrolimus Cream 1% in Pediatric Patients With Mild to Moderate Atopic Dermatitis Completed NCT00510003 Phase 4 Pimecrolimus
23 An Exploratory 16 Week, Double Blind, Placebo-Controlled Single Center Mechanistic Study to Determine the Effect of Rhumab-E25 on Phenotype and Function of IgE Mediated Antigen Presentation by Dendritic Cells in Subjects With Atopic Dermatitis. Completed NCT00822783 Phase 4 Omalizumab;Placebo
24 A Multicenter, Randomized, Double-blind Clinical Study to Examine the Efficacy and Safety of Zarzenda in Comparison to Elidel in the Management of Mild to Moderate Atopic Dermatitis in Children and Adolescents Completed NCT00568412 Phase 4 Elidel
25 An Open-label Multicenter 12-month Long Term Study on Skin Reconstitution With Pimecrolimus Cream 1% in Adult Patients With Atopic Eczema and Corticosteroid Induced Skin Damage Completed NCT00367393 Phase 4 Pimecrolimus cream 1%
26 Pimecrolimus Cream 1% Plus Topical Corticosteroid in Patients (2-17 Years of Age) With Severe Atopic Dermatitis Completed NCT00121381 Phase 4 Pimecrolimus plus topical corticosteroid (TCS);Pimecrolimus vehicle (Placebo) plus topical corticosteroid (TCS)
27 A Randomized, Investigator Blinded Study of Protopic (Tacrolimus) Ointment Vs. Elidel (Pimecrolimus) Cream in Pediatric Patients With Mild Atopic Dermatitis Completed NCT00667160 Phase 4 tacrolimus ointment;pimecrolimus cream
28 Comparison of Pimecrolimus Cream 1% Twice-Daily to Once-Daily Dosing in the Management of Atopic Dermatitis in Pediatric Subjects Completed NCT00139581 Phase 4 Pimecrolimus;Pimecrolimus
29 Efficacy and Safety of Pimecrolimus Cream 1% in Patients (2 to 11 Years Old) With Mild to Moderate Facial Atopic Dermatitis Completed NCT00130364 Phase 4 Pimecrolimus;Placebo
30 Safety and Efficacy of Pimecrolimus Cream 1% in Mild to Moderate Head and Neck Atopic Dermatitis (AD) of Patients Intolerant to, or Dependant on, Topical Corticosteroids Completed NCT00121316 Phase 4 Pimecrolimus;Placebo
31 Phase IV - Evaluation of Cetaphil Advanced Usage to Control Light to Moderate Atopic Dermatitis, in Attempt to Reduce the Necessity of Topic Corticoids Application Completed NCT01063218 Phase 4
32 Comparative, Multicentre, Randomized, Double-blind Study to Assess the Efficacy of Tacrolimus 0.1% Ointment Versus Fluticasone 0.005% Ointment in Adult Patients Suffering From Moderate to Severe Atopic Dermatitis and Presenting With So-called 'Red Face' Lesions of the Head and Neck. Completed NCT00690105 Phase 4 tacrolimus 0.1%;fluticasone 0.005 %
33 Comparative, Multicentre, Randomised, Double-blind Study to Assess the Efficacy of Tacrolimus 0.03% Ointment Versus Fluticasone 0.005% Ointment in Children Aged 2 Years or Over Suffering From Moderate to Severe Atopic Dermatitis. Completed NCT00689832 Phase 4 Tacrolimus 0.03%;Fluticasone 0.005%
34 Quality of Life Study in Adults With Facial Eczema Completed NCT00120302 Phase 4 Pimecrolimus;Placebo
35 A Randomized, Double-blind, Placebo-controlled, Parallel Group Study to Evaluate the Efficacy of Montelukast (Singulair) in Participants Ages 1 - 8 Years Diagnosed With Atopic Dermatitis Induced by Food Allergens Completed NCT00557284 Phase 4 Montelukast;Placebo
36 A Multi-Center, Open-Label Study to Evaluate the Effect of ALTANA Inc's Cutivate (Fluticasone Propionate) Lotion 0.05% on the Hypothalmic Pituitary Adrenal (HPA) Axis in the Treatment of Atopic Dermatitis in a Pediatric Population Completed NCT00546000 Phase 4 Fluticasone propionate 0.05% lotion
37 An Open-Label Study Evaluating the Efficacy of Fluocinonide Cream 0.1% (Vanos) in Subjects With Atopic Dermatitis Completed NCT01049243 Phase 4 Fluocinonide Cream 0.1%
38 Interaction of Orally Administered Lactobacillus Rhamnosus GG With Skin and Gut Microbiota and Humoral Immunity in Infants With Atopic Dermatitis Completed NCT01148667 Phase 4
39 Prospective, Randomized, Investigator-Blind, Controlled, Pilot Study Comparing Effect of Epiceram™ Device vs Standard of Care Therapy of Mid-Strength Topical Steroid (Fluticasone Propionate 0.05%) in Treatment of Atopic Dermatitis in Pediatric Subjects Completed NCT00616538 Phase 4 Fluticasone Propionate 0.05%
40 Management of Pruritus With Xyzal in Atopic Dermatitis in a Randomized, Double-Blind, Placebo Controlled Study Completed NCT00884325 Phase 4 Levocetirizine dihydrochloride (Xyzal);placebo
41 A Randomized, Double-Blinded Study of Epiceram Versus Elidel in Pediatric Subjects With Mild to Moderate Atopic Dermatitis Completed NCT00460083 Phase 4 Elidel(R) (pimecrolimus 1%)
42 A Randomized, Investigator-Blind, Six-Week, Parallel Group, Multicenter Pilot Study to Compare the Safety and Efficacy of EpiCeram Skin Barrier Emulsion and Desonide Cream 0.05% in the Twice Daily Treatment of Pediatric Subjects With Moderate Atopic Dermatitis Completed NCT00828412 Phase 4 Desonide Cream 0.05%
43 Short Term Growth in Children With Atopic Dermatitis Completed NCT00236106 Phase 4 tacrolimus ointment 0.1%;mometasone furoate 0.1%
44 Pimecrolimus Cream 1% (Elidel®) and Medicated Device Cream (EletoneTM) in the Treatment and Maintenance of Atopic Dermatitis. Completed NCT01177566 Phase 4 pimecrolimus
45 Effect of Cetaphil® Restoraderm® Moisturizer on Very Dry Skin in Children With a Controlled Atopic Dermatitis:a Randomised, Parallel Group Study Completed NCT02589392 Phase 4
46 Efficacy of Desonide (Desonatetm) Gel 0.05% in Younger and Older Subjects With Atopic Dermatitis Completed NCT00690833 Phase 4 topical desonide hydrogel 0.05%
47 An Investigator Blinded, Randomized, Controlled Study Comparing the Efficacy and Cost-Effectiveness of Aquaphor Healing Ointment, Atopiclair Nonsteroidal Cream (MAS063DP) and EpiCeram Skin Barrier Emulsion in Children With Mild to Moderate Atopic Dermatitis Completed NCT01093469 Phase 4 Atopiclair Nonsteroidal Cream;EpiCeram
48 Prospective Clinical Trial to Assess the Efficacy and Safety of EPOGAM 1000 in Patients With Atopic Dermatitis (Explorative Pilot Study) Completed NCT00878670 Phase 4 EPOGAM 1000
49 Effects of a Novel Formulation of Fluocinonide 0.1% Cream on Skin Barrier Function in Atopic Dermatitis Completed NCT00819507 Phase 4 Fluocinonide
50 An Open -Label Study to Evaluate the Effect of Pandel Cream 0.1% on the Hypothalamic Pituitary Adrenal Axis in the Pediatric and Adult Population Completed NCT01137032 Phase 4 Pandel Cream 0.1%

Search NIH Clinical Center for Dermatitis, Atopic

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Aloe Vera Leaf
Bendazac
Betamethasone
Betamethasone acetate
Betamethasone benzoate
betamethasone dipropionate
betamethasone sodium phosphate
Betamethasone valerate
BETAMETHASONE VALERATE PWDR
Ciclosporin
Clioquinol
Clobetasone
Cortisone acetate
Dexamethasone
Diphenylpyraline
Doxepin
Doxepin Hydrochloride
fluocinolone
Fluocinolone acetonide
Fluocinolone Acetonide
Hydrocortisone
Hydrocortisone butyrate
methdilazine
Methdilazine hydrochloride
Methylprednisolone
Peanut oil
Pimecrolimus
Prednisolone
Prednisone
Tacrolimus
Triamcinolone
Trimeprazine
trimeprazine tartrate
Triprolidine
Triprolidine Hydrochloride
Zinc Oxide

Cochrane evidence based reviews: dermatitis, atopic

Genetic Tests for Dermatitis, Atopic

Genetic tests related to Dermatitis, Atopic:

# Genetic test Affiliating Genes
1 Dermatitis, Atopic, Susceptibility to, 1 29

Anatomical Context for Dermatitis, Atopic

MalaCards organs/tissues related to Dermatitis, Atopic:

41
Skin, Testes, T Cells, Colon, Monocytes, Breast, Eye

The Foundational Model of Anatomy Ontology organs/tissues related to Dermatitis, Atopic:

19
Skin

Publications for Dermatitis, Atopic

Articles related to Dermatitis, Atopic:

(show top 50) (show all 19271)
# Title Authors PMID Year
1
A nonsynonymous substitution of cystatin A, a cysteine protease inhibitor of house dust mite protease, leads to decreased mRNA stability and shows a significant association with atopic dermatitis. 9 38 8
17441792 2007
2
A major susceptibility locus for atopic dermatitis maps to chromosome 3q21. 9 38 8
11101848 2000
3
Linkage of atopic dermatitis to chromosomes 4q22, 3p24 and 3q21. 38 8
19517137 2009
4
Atopic dermatitis. 38 8
18385500 2008
5
Variants in a novel epidermal collagen gene (COL29A1) are associated with atopic dermatitis. 38 8
17850181 2007
6
Susceptibility loci for atopic dermatitis on chromosomes 3, 13, 15, 17 and 18 in a Swedish population. 38 8
12045207 2002
7
Linkage and association to candidate regions in Swedish atopic dermatitis families. 38 8
11511916 2001
8
Genetic linkage of childhood atopic dermatitis to psoriasis susceptibility loci. 38 8
11279517 2001
9
Association and linkage of atopic dermatitis with chromosome 13q12-14 and 5q31-33 markers. 38 8
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MiR-155 is overexpressed in patients with atopic dermatitis and modulates T-cell proliferative responses by targeting cytotoxic T lymphocyte-associated antigen 4. 38 88
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The prevalence of childhood atopic eczema in a general population. 8
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Aetiology of asthma: lessons from lung transplantation. 8
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Transfer of allergen-specific IgE-mediated hypersensitivity with allogeneic bone marrow transplantation. 8
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Changes in the reported prevalence of childhood eczema since the 1939-45 war. 8
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The lines of Blaschko: a review and reconsideration: Observations of the cause of certain unusual linear conditions of the skin. 8
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Sphingosylphosphorylcholine down-regulates filaggrin gene transcription through NOX5-based NADPH oxidase and cyclooxygenase-2 in human keratinocytes. 9 38
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Thymic stromal lymphopoietin receptor-mediated IL-6 and CC/CXC chemokines expression in human airway smooth muscle cells: role of MAPKs (ERK1/2, p38, and JNK) and STAT3 pathways. 9 38
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[Safety of azathioprine therapy adjusted to thiopurine methyltransferase activity in the treatment of infantile atopic dermatitis. Report on 7 cases]. 9 38
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Flaky tail mouse denotes human atopic dermatitis in the steady state and by topical application with Dermatophagoides pteronyssinus extract. 9 38
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Analysis of four prevalent filaggrin mutations (R501X, 2282del4, R2447X and S3247X) in Austrian and German patients with atopic dermatitis. 9 38
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Definition and characterization of an inhibitor for interleukin-31. 9 38
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Brain-derived neurotrophic factor gene polymorphisms and serum levels in Chinese atopic dermatitis patients. 9 38
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Variations for Dermatitis, Atopic

ClinVar genetic disease variations for Dermatitis, Atopic:

6 (show all 12)
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 FLG NM_002016.1(FLG): c.1501C> T (p.Arg501Ter) single nucleotide variant Pathogenic rs61816761 1:152285861-152285861 1:152313385-152313385
2 STAT1 NM_007315.3(STAT1): c.821G> A (p.Arg274Gln) single nucleotide variant Pathogenic rs387906760 2:191859910-191859910 2:190995184-190995184
3 46;XX;t(7;13)(p13;q34)dn Translocation Pathogenic
4 46;XY;t(2;17)(p25;q23)dn Translocation Pathogenic
5 46;X;t(X;12)(p11.2;q24.33)dn Translocation Likely pathogenic
6 KCNJ11 NM_000525.3(KCNJ11): c.185C> G (p.Thr62Arg) single nucleotide variant Likely pathogenic rs1057518775 11:17409454-17409454 11:17387907-17387907
7 CYP4F22 NM_173483.4(CYP4F22): c.1211T> C (p.Leu404Pro) single nucleotide variant Uncertain significance rs1555730246 19:15658993-15658993 19:15548182-15548182
8 CYP4F22 NM_173483.4(CYP4F22): c.1544G> T (p.Arg515Leu) single nucleotide variant Uncertain significance rs1425964436 19:15662230-15662230 19:15551419-15551419
9 46;XY;t(16;20)(q23.1;p11.22) Translocation Uncertain significance
10 46;XY;t(1;4)(q32;q11) Translocation Uncertain significance
11 XDH NM_000379.4(XDH): c.3647C> A (p.Pro1216His) single nucleotide variant Uncertain significance rs143981573 2:31562482-31562482 2:31339616-31339616
12 XDH NM_000379.4(XDH): c.1172C> T (p.Pro391Leu) single nucleotide variant Uncertain significance 2:31602803-31602803 2:31379937-31379937

Expression for Dermatitis, Atopic

Search GEO for disease gene expression data for Dermatitis, Atopic.

Pathways for Dermatitis, Atopic

Pathways related to Dermatitis, Atopic according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.57 TSLP IL5 IL4R IL4 IL31 IL13
2
Show member pathways
13.25 STAT1 IL5 IL4R IL4 IL31 IL13
3
Show member pathways
12.77 STAT1 RNASE3 IL5 IL4R IL4 IL13
4 12.73 STAT1 IL5 IL4R IL4 IL13
5
Show member pathways
12.47 STAT1 IL5 IL4R IL4 IL13
6
Show member pathways
12.28 STAT1 IL4R IL4 FCER2
7
Show member pathways
12.21 IL5 IL4 IL13 CCL17
8
Show member pathways
12.16 TSLP STAT1 IL5 IL4R IL4 IL13
9
Show member pathways
12.13 STAT1 IL5 IL4 IL13
10
Show member pathways
11.89 STAT1 IL5 IL4R IL4 IL13 CCL17
11
Show member pathways
11.88 STAT1 IL5 IL13
12 11.76 IL5 IL4R IL4 FCER2
13 11.71 STAT1 IL4R IL4 IL13 FCER2
14 11.67 STAT1 IL5 IL4 IL13
15 11.64 TSLP IL5 IL4 IL13
16 11.61 IL4 IL13 CCL17
17 11.47 IL5 IL4 IL13 CMA1
18 11.42 IL4 IL13 FCER2
19 11.22 IL5 IL4R IL4
20 11.15 IL5 IL4 IL13
21 11.15 IL5 IL4R IL4 FCER2 CCL17
22 11.1 IL5 IL4 IL13 CCL17
23 11.09 IL5 IL4 IL13
24 10.96 TSLP IL5 IL4 IL13
25 10.76 IL5 IL4R IL4 IL31 IL13 CCL17

GO Terms for Dermatitis, Atopic

Cellular components related to Dermatitis, Atopic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 TSLP RNASE3 IL5 IL4R IL4 IL31
2 extracellular space GO:0005615 9.32 TSLP RNASE3 MIR155 IL5 IL4R IL4

Biological processes related to Dermatitis, Atopic according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.85 IL5 IL4R IL4 IL13 CCL17
2 positive regulation of cold-induced thermogenesis GO:0120162 9.67 IL4R IL4 IL13
3 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.54 TSLP IL4 IL13
4 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.48 STAT1 FCER2
5 positive regulation of mast cell degranulation GO:0043306 9.43 IL4R IL13
6 positive regulation of B cell proliferation GO:0030890 9.43 IL5 IL4 IL13
7 positive regulation of interleukin-13 production GO:0032736 9.4 TSLP IL4
8 positive regulation of immunoglobulin production GO:0002639 9.32 IL4R IL13
9 cytokine-mediated signaling pathway GO:0019221 9.17 STAT1 IL5 IL4R IL4 IL31 IL13
10 negative regulation of complement-dependent cytotoxicity GO:1903660 9.16 IL4 IL13
11 positive regulation of macrophage activation GO:0043032 9.13 MIR155 IL4R IL13

Molecular functions related to Dermatitis, Atopic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine receptor binding GO:0005126 9.13 IL4 IL31 IL13
2 cytokine activity GO:0005125 9.1 TSLP IL5 IL4 IL31 IL13 CCL17