Dermatitis, Atopic, 2 (ATOD2)

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OMIM 57 605803 Disease Ontology 12 DOID:0110098 MedGen 42 C1853965

MeSH 44 D003876 UMLS 73 C1853965 C0011615

UniProtKB/Swiss-Prot : ⁷⁵ Dermatitis atopic 2: Atopic dermatitis is a complex, inflammatory disease with multiple alleles at several loci thought to be involved in the pathogenesis. It commonly begins in infancy or early childhood and is characterized by a chronic relapsing form of skin inflammation, a disturbance of epidermal barrier function that culminates in dry skin, and IgE- mediated sensitization to food and environmental allergens. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee.

MalaCards based summary : Dermatitis, Atopic, 2, also known as atod2, is related to ichthyosis vulgaris and ichthyosis, and has symptoms including pruritus and exanthema. An important gene associated with Dermatitis, Atopic, 2 is FLG (Filaggrin), and among its related pathways/superpathways is Keratinization. Affiliated tissues include skin, colon and liver.

Disease Ontology : ¹² An atopic dermatitis conferred by variation in the FLG gene on chromosome 1q21.

Description from OMIM: 605803

Clinical features from OMIM:

605803

Search Clinical Trials , NIH Clinical Center for Dermatitis, Atopic, 2

betamethasone betamethasone acetate betamethasone benzoate betamethasone dipropionate betamethasone sodium phosphate betamethasone valerate betamethasone valerate pwdr doxepin doxepin hydrochloride fluocinolone

fluocinolone acetonide methdilazine methdilazine hydrochloride pimecrolimus tacrolimus trimeprazine trimeprazine tartrate triprolidine triprolidine hydrochloride zinc oxide

Search GEO for disease gene expression data for Dermatitis, Atopic, 2.