ATOD5
MCID: DRM057
MIFTS: 33

Dermatitis, Atopic, 5 (ATOD5)

Categories: Genetic diseases, Immune diseases, Neuronal diseases, Skin diseases
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Aliases & Classifications for Dermatitis, Atopic, 5

MalaCards integrated aliases for Dermatitis, Atopic, 5:

Name: Dermatitis, Atopic, 5 57 12 71
Atopic Dermatitis 5 11 14
Atod5 57 11
Dermatitis, Atopic, Susceptibility to, 5 57
Dermatitis, Atopic 5 57

Classifications:



External Ids:

Disease Ontology 11 DOID:0110101
OMIM® 57 605844
OMIM Phenotypic Series 57 PS603165
MedGen 40 C1853900
UMLS 71 C1853900

Summaries for Dermatitis, Atopic, 5

Disease Ontology: 11 An atopic dermatitis associated with variation in the region 13q12-q14.

MalaCards based summary: Dermatitis, Atopic, 5, also known as atopic dermatitis 5, is related to dermatitis, atopic and dermatitis. An important gene associated with Dermatitis, Atopic, 5 is ATOD5 (Dermatitis, Atopic, 5), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include skin, and related phenotypes are no phenotypic analysis and endocrine/exocrine gland

More information from OMIM: 605844 PS603165

Related Diseases for Dermatitis, Atopic, 5

Diseases in the Dermatitis, Atopic family:

Dermatitis, Atopic, 2 Dermatitis, Atopic, 3
Dermatitis, Atopic, 4 Dermatitis, Atopic, 5
Dermatitis, Atopic, 6 Dermatitis, Atopic, 7
Dermatitis, Atopic, 8 Dermatitis, Atopic, 9

Diseases related to Dermatitis, Atopic, 5 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Related Disease Score Top Affiliating Genes
1 dermatitis, atopic 30.1 TSLP PTGDR2 ITGAX IL33 GATA3 FCGR3A
2 dermatitis 10.3
3 bronchiectasis 1 10.2 KLRG1 IL7R
4 chronic rhinitis 10.2 PTGDR2 IL33
5 goat milk allergy 10.2 TSLP IL33
6 chronic ethmoiditis 10.2 TSLP IL33
7 near-fatal asthma 10.2 TSLP IL33
8 aneruptive fever 10.2 TBX21 GATA3
9 cryoglobulinemia, familial mixed 10.1 TSLP CD5
10 intermittent asthma 10.1 TSLP IL33
11 occupational asthma 10.1 TSLP IL33
12 environmental induced asthma 10.1 TSLP IL33
13 chronic spontaneous urticaria 10.1 TSLP IL33
14 t2-low asthma 10.1 TSLP PTGDR2 IL33
15 type 1 diabetes mellitus 21 10.1 TBX21 GATA3
16 t2-high asthma 10.1 TSLP PTGDR2 IL33
17 pneumothorax, primary spontaneous 10.1 TSLP PTGDR2 IL33
18 legume allergy 10.1 TSLP PTGDR2 IL33
19 fruit allergy 10.1 TSLP PTGDR2 IL33
20 esophagitis, eosinophilic, 1 10.1 TSLP PTGDR2 IL33
21 common cold 10.1 TSLP PTGDR2 IL33
22 contact dermatitis 10.1 TSLP PTGDR2 IL33
23 peanut allergy 10.1 TSLP IL33
24 chronic conjunctivitis 10.0 TSLP IL33
25 b-cell prolymphocytic leukemia 10.0 ITGAX CD5
26 acute asthma 10.0 TSLP IL33
27 lethal midline granuloma 10.0 FCGR3B CD5
28 conjunctivitis 10.0 PTGDR2 IL7 IL33
29 retinal detachment 10.0
30 allergic rhinitis 10.0
31 food allergy 10.0
32 severe combined immunodeficiency, x-linked 10.0 TSLP IL7R IL7
33 rhinitis 9.9 TSLP IL33 GATA3
34 nasal cavity disease 9.9 TSLP PTGDR2 IL33 GATA3
35 nose disease 9.9 TSLP PTGDR2 IL33 GATA3
36 spleen cancer 9.9 ITGAX CD5
37 b-cell expansion with nfkb and t-cell anergy 9.9 FCGR3B CD5
38 primary cutaneous t-cell non-hodgkin lymphoma 9.9 IL7R IL7 CD5
39 listeriosis 9.8 TBX21 KLRG1 ITGAX IL7R
40 splenic marginal zone lymphoma 9.8 ITGAX CD5
41 spastic paraplegia 32, autosomal recessive 9.8 FCGR3B FCGR3A
42 sezary's disease 9.8 IL7 GATA3 CD5
43 oxirane allergy 9.8 FCGR3B FCGR3A
44 chronic nk-cell lymphocytosis 9.8 FCGR3B FCGR3A
45 bronchiectasis 3 9.8 FCGR3B FCGR3A
46 developmental and epileptic encephalopathy 38 9.8 FCGR3B FCGR3A
47 immunodeficiency 20 9.8 FCGR3B FCGR3A
48 autoimmune myocarditis 9.7 TBX21 ITGAX
49 felty syndrome 9.7 FCGR3B FCGR3A
50 critical covid-19 9.7 IL7 FCGR3B

Graphical network of the top 20 diseases related to Dermatitis, Atopic, 5:



Diseases related to Dermatitis, Atopic, 5

Symptoms & Phenotypes for Dermatitis, Atopic, 5

Clinical features from OMIM®:

605844 (Updated 24-Oct-2022)

MGI Mouse Phenotypes related to Dermatitis, Atopic, 5:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 no phenotypic analysis MP:0003012 9.91 CD5 FCGR3A FCGR3B GATA3 ICOS IL33
2 endocrine/exocrine gland MP:0005379 9.81 AMBP GATA3 GUSB ICOS IL33 IL7
3 immune system MP:0005387 9.77 CD5 FCGR3A FCGR3B GATA3 ICOS IL33
4 hematopoietic system MP:0005397 9.47 CD5 FCGR3A FCGR3B GATA3 GUSB ICOS

Drugs & Therapeutics for Dermatitis, Atopic, 5

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Multi-center, Open, Long-term Follow-up Study to Evaluate the Efficacy and Safety of FURESTEM-AD Inj. in Patients With Moderate to Severe Chronic Atopic Dermatitis: 5-year Results From the K0102 Extension Study Active, not recruiting NCT03962387
2 Long-term Follow-up Study to Evaluate the Safety and Explore the Efficacy of Multiple Doses of FURESTEM-AD Inj. for Moderate to Severe Chronic Atopic Dermatitis: 5-year Results From the K0104 Extension Study Not yet recruiting NCT04730024

Search NIH Clinical Center for Dermatitis, Atopic, 5

Genetic Tests for Dermatitis, Atopic, 5

Anatomical Context for Dermatitis, Atopic, 5

Organs/tissues related to Dermatitis, Atopic, 5:

MalaCards : Skin

Publications for Dermatitis, Atopic, 5

Articles related to Dermatitis, Atopic, 5:

(show all 16)
# Title Authors PMID Year
1
Susceptibility loci for atopic dermatitis on chromosomes 3, 13, 15, 17 and 18 in a Swedish population. 57
12045207 2002
2
Association and linkage of atopic dermatitis with chromosome 13q12-14 and 5q31-33 markers. 57
11069631 2000
3
Emollients for prevention of atopic dermatitis; 5-year findings from the BEEP randomised trial. 62
36263451 2022
4
A Journey into Atopic Dermatitis: 5 Experts' Reviews Appearing in DPCJ Next Issues. 62
35024239 2021
5
Revolutionizing Atopic Dermatitis, 5 April 2020. 62
32242919 2020
6
Effects of Merino Wool on Atopic Dermatitis Using Clinical, Quality of Life, and Physiological Outcome Measures. 62
30864970 2019
7
Epicutaneous allergen application preferentially boosts specific T cell responses in sensitized patients. 62
28912492 2017
8
The Trend of Change of Allergic Diseases over the Years: Three Repeated Surveys from 1994 to 2014. 62
28787739 2017
9
Urticarial dermatitis: clinical features, diagnostic evaluation, and etiologic associations in a series of 146 patients at Mayo Clinic (2006-2012). 62
24268310 2014
10
Characteristics and completeness of clinical trial registrations in psoriasis and atopic dermatitis. 62
17199575 2007
11
Japanese cedar pollen as an exacerbation factor in atopic dermatitis: results of atopy patch testing and histological examination. 62
16648919 2006
12
[Coexistent diseases in allergic asthmatic patients. A study of 100 cases]. 62
15491076 2004
13
Interleukin 4 and interferon-gamma expression of the dermal infiltrate in patients with erythroderma and mycosis fungoides. An immuno-histochemical study. 62
11028812 2000
14
Type-1 hypersensitivity reactions to Malassezia pachydermatis extracts in atopic dogs. 62
9659547 1998
15
Retinal detachment in patients with atopic dermatitis. 5-year retrospective survey. 62
7630624 1995
16
[Use of a new radioenzymatic test in urticaria and drug allergy]. 62
95431 1979

Variations for Dermatitis, Atopic, 5

Expression for Dermatitis, Atopic, 5

Search GEO for disease gene expression data for Dermatitis, Atopic, 5.

Pathways for Dermatitis, Atopic, 5

GO Terms for Dermatitis, Atopic, 5

Biological processes related to Dermatitis, Atopic, 5 according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 10.18 KLRG1 KLRB1 IL7R FCGR3B FCGR3A
2 positive regulation of gene expression GO:0010628 9.97 GATA3 IL33 IL7 IL7R ITGAX TBX21
3 positive regulation of chemokine production GO:0032722 9.93 TSLP IL7 IL33
4 immune response GO:0006955 9.9 PTGDR2 IL7R IL7 ICOS FCGR3B FCGR3A
5 positive regulation of cytokine-mediated signaling pathway GO:0001961 9.8 TSLP IL7
6 regulation of immune response GO:0050776 9.8 TBX21 FCGR3B FCGR3A
7 positive regulation of receptor signaling pathway via STAT GO:1904894 9.73 TSLP IL7R
8 T cell differentiation GO:0030217 9.67 TBX21 IL7R GATA3
9 lymphocyte migration GO:0072676 9.56 TBX21 GATA3
10 positive regulation of interleukin-13 production GO:0032736 9.43 TSLP IL33 GATA3
11 positive regulation of interleukin-5 production GO:0032754 9.1 TSLP IL33 GATA3

Molecular functions related to Dermatitis, Atopic, 5 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 9.92 NCR2 KLRB1 FCGR3B FCGR3A
2 carbohydrate binding GO:0030246 9.86 KLRG1 KLRB1 GUSB AMBP
3 signaling receptor activity GO:0038023 9.65 NCR2 KLRG1 KLRB1 ITGAX CD5
4 IgG binding GO:0019864 9.46 FCGR3B FCGR3A
5 interleukin-7 receptor binding GO:0005139 8.92 TSLP IL7

Sources for Dermatitis, Atopic, 5

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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