ATOD5
MCID: DRM057
MIFTS: 33

Dermatitis, Atopic, 5 (ATOD5)

Categories: Genetic diseases, Immune diseases, Neuronal diseases, Skin diseases

Aliases & Classifications for Dermatitis, Atopic, 5

MalaCards integrated aliases for Dermatitis, Atopic, 5:

Name: Dermatitis, Atopic, 5 57 71
Dermatitis, Atopic, Susceptibility to, 5 57 13
Atopic Dermatitis 5 12 15
Atod5 57 12
Dermatitis, Atopic 5 57

Classifications:



External Ids:

Disease Ontology 12 DOID:0110101
OMIM® 57 605844
OMIM Phenotypic Series 57 PS603165
MedGen 41 C1853900
UMLS 71 C1853900

Summaries for Dermatitis, Atopic, 5

Disease Ontology : 12 An atopic dermatitis associated with variation in the region 13q12-q14.

MalaCards based summary : Dermatitis, Atopic, 5, also known as dermatitis, atopic, susceptibility to, 5, is related to dermatitis, atopic and dermatitis. An important gene associated with Dermatitis, Atopic, 5 is ATOD5 (Dermatitis, Atopic, 5), and among its related pathways/superpathways are Innate Immune System and NF-kappaB Signaling. Related phenotypes are hematopoietic system and immune system

More information from OMIM: 605844 PS603165

Related Diseases for Dermatitis, Atopic, 5

Diseases in the Dermatitis, Atopic family:

Dermatitis, Atopic, 2 Dermatitis, Atopic, 3
Dermatitis, Atopic, 4 Dermatitis, Atopic, 5
Dermatitis, Atopic, 6 Dermatitis, Atopic, 7
Dermatitis, Atopic, 8 Dermatitis, Atopic, 9

Diseases related to Dermatitis, Atopic, 5 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Related Disease Score Top Affiliating Genes
1 dermatitis, atopic 30.7 TSLP PTGDR2 IL33 GATA3 FCGR3A ATOD5
2 dermatitis 11.1
3 timothy grass allergy 10.3 PTGDR2 AMBP
4 aneruptive fever 10.2 TBX21 GATA3
5 cryoglobulinemia, familial mixed 10.2 TSLP CD5
6 mental retardation, autosomal dominant 33 10.2 TSLP IL7R
7 thyroid lymphoma 10.2 IL7R IL7
8 macular degeneration, age-related, 8 10.2 TBX21 KLRG1 IL7R
9 pneumothorax, primary spontaneous 10.2 TSLP PTGDR2 IL33
10 chronic spontaneous urticaria 10.1 TSLP PTGDR2 IL33
11 esophagitis, eosinophilic, 1 10.1 TSLP PTGDR2 IL33
12 common cold 10.1 TSLP PTGDR2 IL33
13 type 1 diabetes mellitus 21 10.1 TBX21 GATA3
14 ureter transitional cell carcinoma 10.1 NCAM1 GATA3
15 immunodeficiency 27b 10.1 TBX21 GATA3
16 ureter small cell carcinoma 10.1 NCAM1 GATA3
17 thymus clear cell carcinoma 10.1 GATA3 CD5
18 urinary bladder small cell neuroendocrine carcinoma 10.1 NCAM1 GATA3
19 legume allergy 10.1 TSLP IL33
20 severe combined immunodeficiency, x-linked 10.1 TSLP IL7R IL7
21 papillary thymic adenocarcinoma 10.0 NCAM1 CD5
22 conjunctivitis 10.0 PTGDR2 IL7 IL33
23 breast neuroendocrine neoplasm 10.0 NCAM1 GATA3
24 nasal cavity lymphoma 10.0 NCAM1 CD5
25 gastrointestinal lymphoma 10.0 NCAM1 CD5
26 fruit allergy 10.0 TSLP IL33
27 mediastinal cancer 10.0 NCAM1 CD5
28 microscopic polyangiitis 10.0 FCGR3B FCGR3A
29 retinal detachment 10.0
30 nasal cavity disease 10.0 TSLP PTGDR2 IL33 GATA3
31 nose disease 10.0 TSLP PTGDR2 IL33 GATA3
32 transient neonatal neutropenia 10.0 FCGR3B FCGR3A
33 oxirane allergy 9.9 FCGR3B FCGR3A
34 herpetic whitlow 9.9 FCGR3B FCGR3A
35 gastroenteritis 9.9 TSLP IL33 GUSB GATA3
36 immunodeficiency 20 9.9 FCGR3B FCGR3A
37 rhinitis 9.9 TSLP IL33 GATA3
38 anauxetic dysplasia 1 9.9 FCGR3B FCGR3A
39 chronic conjunctivitis 9.9 TSLP IL33
40 trichothiodystrophy 5, nonphotosensitive 9.8 FCGR3B FCGR3A
41 cardiomyopathy, dilated, 1c, with or without left ventricular noncompaction 9.8 IL7R FCGR3B FCGR3A
42 peripheral t-cell lymphoma 9.8 NCAM1 GATA3 CD5
43 autoimmune disease of central nervous system 9.8 TBX21 ITGAX IL7R
44 autoimmune disease of the nervous system 9.8 TBX21 ITGAX IL7R
45 allergic disease 9.7 TSLP IL33 ICOS GATA3 CD5
46 listeriosis 9.7 TBX21 KLRG1 ITGAX IL7R
47 chronic nk-cell lymphocytosis 9.7 NCAM1 FCGR3B FCGR3A
48 selective igg deficiency disease 9.7 NCAM1 FCGR3B FCGR3A
49 mosaic variegated aneuploidy syndrome 2 9.7 NCAM1 FCGR3B FCGR3A
50 integumentary system disease 9.7 TSLP ITGAX IL33

Graphical network of the top 20 diseases related to Dermatitis, Atopic, 5:



Diseases related to Dermatitis, Atopic, 5

Symptoms & Phenotypes for Dermatitis, Atopic, 5

Clinical features from OMIM®:

605844 (Updated 05-Mar-2021)

MGI Mouse Phenotypes related to Dermatitis, Atopic, 5:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.97 CD5 FCGR3B GATA3 GUSB ICOS IL33
2 immune system MP:0005387 9.73 CD5 FCGR3B GATA3 ICOS IL33 IL7
3 no phenotypic analysis MP:0003012 9.23 CD5 FCGR3B GATA3 ICOS IL33 IL7

Drugs & Therapeutics for Dermatitis, Atopic, 5

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Multi-center, Open, Long-term Follow-up Study to Evaluate the Efficacy and Safety of FURESTEM-AD Inj. in Patients With Moderate to Severe Chronic Atopic Dermatitis: 5-year Results From the K0102 Extension Study Recruiting NCT03962387
2 Long-term Follow-up Study to Evaluate the Safety and Explore the Efficacy of Multiple Doses of FURESTEM-AD Inj. for Moderate to Severe Chronic Atopic Dermatitis: 5-year Results From the K0104 Extension Study Not yet recruiting NCT04730024

Search NIH Clinical Center for Dermatitis, Atopic, 5

Genetic Tests for Dermatitis, Atopic, 5

Anatomical Context for Dermatitis, Atopic, 5

Publications for Dermatitis, Atopic, 5

Articles related to Dermatitis, Atopic, 5:

(show all 14)
# Title Authors PMID Year
1
Susceptibility loci for atopic dermatitis on chromosomes 3, 13, 15, 17 and 18 in a Swedish population. 57
12045207 2002
2
Association and linkage of atopic dermatitis with chromosome 13q12-14 and 5q31-33 markers. 57
11069631 2000
3
Revolutionizing Atopic Dermatitis, 5 April 2020. 61
32242919 2020
4
Effects of Merino Wool on Atopic Dermatitis Using Clinical, Quality of Life, and Physiological Outcome Measures. 61
30864970 2019
5
Epicutaneous allergen application preferentially boosts specific T cell responses in sensitized patients. 61
28912492 2017
6
The Trend of Change of Allergic Diseases over the Years: Three Repeated Surveys from 1994 to 2014. 61
28787739 2017
7
Urticarial dermatitis: clinical features, diagnostic evaluation, and etiologic associations in a series of 146 patients at Mayo Clinic (2006-2012). 61
24268310 2014
8
Characteristics and completeness of clinical trial registrations in psoriasis and atopic dermatitis. 61
17199575 2007
9
Japanese cedar pollen as an exacerbation factor in atopic dermatitis: results of atopy patch testing and histological examination. 61
16648919 2006
10
[Coexistent diseases in allergic asthmatic patients. A study of 100 cases]. 61
15491076 2004
11
Interleukin 4 and interferon-gamma expression of the dermal infiltrate in patients with erythroderma and mycosis fungoides. An immuno-histochemical study. 61
11028812 2000
12
Type-1 hypersensitivity reactions to Malassezia pachydermatis extracts in atopic dogs. 61
9659547 1998
13
Retinal detachment in patients with atopic dermatitis. 5-year retrospective survey. 61
7630624 1995
14
[Use of a new radioenzymatic test in urticaria and drug allergy]. 61
95431 1979

Variations for Dermatitis, Atopic, 5

Expression for Dermatitis, Atopic, 5

Search GEO for disease gene expression data for Dermatitis, Atopic, 5.

Pathways for Dermatitis, Atopic, 5

GO Terms for Dermatitis, Atopic, 5

Cellular components related to Dermatitis, Atopic, 5 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.93 PTGDR2 NCR2 NCAM1 KLRG1 KLRB1 ITGAX
2 external side of plasma membrane GO:0009897 9.35 NCAM1 ITGAX IL7R FCGR3A CD5
3 extracellular region GO:0005576 9.32 TSLP NCAM1 IL7R IL7 IL33 ICOS

Biological processes related to Dermatitis, Atopic, 5 according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.8 KLRG1 KLRB1 IL7R FCGR3B FCGR3A
2 positive regulation of gene expression GO:0010628 9.8 TBX21 ITGAX IL7R IL7 IL33 GATA3
3 immune response GO:0006955 9.73 PTGDR2 IL7R IL7 ICOS FCGR3B FCGR3A
4 T cell differentiation GO:0030217 9.63 TBX21 IL7R GATA3
5 positive regulation of chemokine production GO:0032722 9.61 TSLP IL7 IL33
6 positive regulation of interleukin-4 production GO:0032753 9.55 IL33 GATA3
7 regulation of immune response GO:0050776 9.55 TBX21 NCR2 KLRB1 FCGR3B FCGR3A
8 homeostasis of number of cells GO:0048872 9.54 IL7R GATA3
9 interleukin-7-mediated signaling pathway GO:0038111 9.54 TSLP IL7R IL7
10 positive regulation of T cell differentiation GO:0045582 9.52 IL7 GATA3
11 positive regulation of cytokine-mediated signaling pathway GO:0001961 9.51 TSLP IL7
12 positive regulation of STAT cascade GO:1904894 9.49 TSLP IL7R
13 lymphocyte migration GO:0072676 9.48 TBX21 GATA3
14 positive regulation of interleukin-13 production GO:0032736 9.13 TSLP IL33 GATA3
15 positive regulation of interleukin-5 production GO:0032754 8.8 TSLP IL33 GATA3

Molecular functions related to Dermatitis, Atopic, 5 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 9.56 NCR2 KLRB1 FCGR3B FCGR3A
2 signaling receptor activity GO:0038023 9.26 NCR2 KLRG1 ITGAX CD5
3 IgG binding GO:0019864 9.16 FCGR3B FCGR3A
4 interleukin-7 receptor binding GO:0005139 8.62 TSLP IL7

Sources for Dermatitis, Atopic, 5

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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