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ATOD8
MCID: DRM060
MIFTS: 30

Dermatitis, Atopic, 8 (ATOD8)

Categories: Genetic diseases, Immune diseases, Neuronal diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Dermatitis, Atopic, 8

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MalaCards integrated aliases for Dermatitis, Atopic, 8:

Name: Dermatitis, Atopic, 8 56 71
Atopic Dermatitis 8 12 15
Atod8 56 12
Dermatitis, Atopic, Susceptibility to, 8 56
Dermatitis, Atopic, Severity of 56
Dermatitis, Atopic 8 56

Classifications:

MalaCards categories:
Global: Genetic diseases
Anatomical: Skin diseases Neuronal diseases Immune diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0110104
OMIM 56 613518
OMIM Phenotypic Series 56 PS603165
UMLS 71 C3150763
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Summaries for Dermatitis, Atopic, 8

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Disease Ontology : 12 An atopic dermatitis associated with variation in the region 4q22.1.

MalaCards based summary : Dermatitis, Atopic, 8, also known as atopic dermatitis 8, is related to dermatitis, atopic and palladium allergic contact dermatitis. An important gene associated with Dermatitis, Atopic, 8 is ATOD8 (Dermatitis, Atopic, 8), and among its related pathways/superpathways are Allograft rejection and Immune response IFN alpha/beta signaling pathway. Affiliated tissues include skin and t cells.

More information from OMIM: 613518 PS603165
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Related Diseases for Dermatitis, Atopic, 8

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Diseases in the Dermatitis, Atopic family:

Dermatitis, Atopic, 2 Dermatitis, Atopic, 3
Dermatitis, Atopic, 4 Dermatitis, Atopic, 5
Dermatitis, Atopic, 6 Dermatitis, Atopic, 7
Dermatitis, Atopic, 8 Dermatitis, Atopic, 9

Diseases related to Dermatitis, Atopic, 8 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 216)
# Related Disease Score Top Affiliating Genes
1 dermatitis, atopic 30.8 IL1B IL10 CXCL8 ATOD8
2 palladium allergic contact dermatitis 10.0 IL1B IL10
3 eales disease 10.0 IL1B IL10
4 idiopathic neutropenia 10.0 IL1B IL10
5 cysticercosis 10.0 IL1B IL10
6 autoimmune gastritis 10.0 IL1B IL10
7 fascioliasis 10.0 IL1B IL10
8 acute disseminated encephalomyelitis 10.0 IL1B IL10
9 scrub typhus 10.0 IL1B IL10
10 extrapulmonary tuberculosis 10.0 IL1B IL10
11 blau syndrome 10.0 IL1B IL10
12 q fever 10.0 IL1B IL10
13 neonatal jaundice 10.0 IL1B IL10
14 autoimmune uveitis 10.0 IL1B IL10
15 rheumatic heart disease 10.0 IL1B IL10
16 extrinsic cardiomyopathy 9.9 IL1B IL10
17 graft-versus-host disease 9.9 IL1B IL10
18 autoimmune polyendocrine syndrome 9.9 IL1B IL10
19 hair disease 9.9 IL10 CDAN1
20 multinodular goiter 9.9 IL1B IL10
21 myelitis 9.9 IL10 CXCL8
22 ileus 9.9 IL1B IL10
23 acute transverse myelitis 9.9 IL10 CXCL8
24 transverse myelitis 9.9 IL10 CXCL8
25 neurosyphilis 9.9 IL10 CXCL8
26 salmonellosis 9.9 IL1B IL10
27 mycetoma 9.9 IL10 CXCL8
28 bone sarcoma 9.9 IL10 CXCL8
29 primary peritoneal carcinoma 9.9 IL10 CXCL8
30 chlamydia pneumonia 9.9 IL10 CXCL8
31 clonorchiasis 9.9 IL10 CXCL8
32 scabies 9.9 IL10 CXCL8
33 vulvovaginitis 9.9 IL10 CXCL8
34 chronic conjunctivitis 9.9 IL10 CXCL8
35 conjunctivitis 9.9 IL10 CXCL8
36 viral pneumonia 9.9 IL10 CXCL8
37 familial mediterranean fever 9.9 IL1B IL10
38 bronchopneumonia 9.9 IL10 CXCL8
39 relapsing polychondritis 9.9 IL10 CXCL8
40 streptococcus pneumonia 9.9 IL10 CXCL8
41 status asthmaticus 9.9 IL10 CXCL8
42 radiculopathy 9.8 IL10 CXCL8
43 acute pyelonephritis 9.8 IL10 CXCL8
44 dermatitis herpetiformis 9.8 IL10 CXCL8
45 anus disease 9.8 IL10 CXCL8
46 churg-strauss syndrome 9.8 IL10 CXCL8
47 rectal disease 9.8 IL10 CXCL8
48 invasive aspergillosis 9.8 IL10 CXCL8
49 bacterial sepsis 9.8 IL10 CXCL8
50 opportunistic mycosis 9.8 IL10 CXCL8

Graphical network of the top 20 diseases related to Dermatitis, Atopic, 8:



Diseases related to Dermatitis, Atopic, 8
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Symptoms & Phenotypes for Dermatitis, Atopic, 8

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Clinical features from OMIM:

613518
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Drugs & Therapeutics for Dermatitis, Atopic, 8

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Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase IV Study Of The Impact Of Vorinostat On Cellular Signaling And Cytokine Production In Cutaneous T-Cell Lymphoma Patients With Pruritus Withdrawn NCT01801670

Search NIH Clinical Center for Dermatitis, Atopic, 8

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Genetic Tests for Dermatitis, Atopic, 8

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Anatomical Context for Dermatitis, Atopic, 8

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MalaCards organs/tissues related to Dermatitis, Atopic, 8:

40
Skin, T Cells
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Publications for Dermatitis, Atopic, 8

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Articles related to Dermatitis, Atopic, 8:

# Title Authors PMID Year
1
Linkage of atopic dermatitis to chromosomes 4q22, 3p24 and 3q21. 56
19517137 2009
2
[Prevalence of allergic diseases in children with secondary renal tubular acidosis attending a tertiary care pediatric center]. 61
28658721 2017
3
Review of an established UK home phototherapy service 1998-2011: improving access to a cost-effective treatment for chronic skin disease. 61
24726005 2014
4
A distinct profile of serum levels of soluble intercellular adhesion molecule-1 and intercellular adhesion molecule-3 in mycosis fungoides and Sézary syndrome. 61
19615537 2009
5
Analysis of inpatient dermatologic referrals: insight into the educational needs of trainee doctors. 61
19002549 2009
6
Immunofluorescence of the skin in allergic diseases: an investigation of patients with contact dermatitis, allergic vasculitis and atopic dermatitis. 61
76388 1978
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Variations for Dermatitis, Atopic, 8

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Expression for Dermatitis, Atopic, 8

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Search GEO for disease gene expression data for Dermatitis, Atopic, 8.
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Pathways for Dermatitis, Atopic, 8

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Pathways related to Dermatitis, Atopic, 8 according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Allograft rejection 36 1
Show member pathways
 12.48 IL1B IL10 CXCL8
2
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 11.88 IL1B IL10 CXCL8
3
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.79 IL1B IL10 CXCL8
4
Yersinia infection 36
11.62 IL1B IL10 CXCL8
5
Interleukin-4 and 13 signaling 65
11.55 IL1B IL10 CXCL8
6
Salmonella infection (KEGG) 36
11.49 IL1B CXCL8
7
Innate Lymphoid Cell Differentiation Pathways 64
11.48 IL1B IL10
8
Dendritic Cells Developmental Lineage Pathway 64
11.44 IL1B IL10
9
Amoebiasis 36
11.44 IL1B IL10 CXCL8
10
Microglia Activation During Neuroinflammation: Microglia Polarization 64
11.4 IL1B IL10
11
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.34 IL1B CXCL8
12
Lung fibrosis 1
11.32 IL1B CXCL8
13
Legionellosis 36
11.27 IL1B CXCL8
14
Pertussis 36
11.21 IL1B IL10 CXCL8
15
African trypanosomiasis 36
11.05 IL1B IL10
16
IL-10 Pathway 63
11 IL1B IL10
17
Cytokines and Inflammatory Response 1
10.9 IL1B IL10
18
Malaria 36
10.83 IL1B IL10 CXCL8
19
G-protein signaling_Rap2B regulation pathway 22
10.67 IL1B IL10 CXCL8
20
Interleukin-10 signaling 65
10.49 IL1B IL10 CXCL8
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GO Terms for Dermatitis, Atopic, 8

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Biological processes related to Dermatitis, Atopic, 8 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.61 IL1B IL10 CXCL8
2 negative regulation of cell proliferation GO:0008285 9.58 IL1B IL10 CXCL8
3 inflammatory response GO:0006954 9.54 IL1B IL10 CXCL8
4 cytokine-mediated signaling pathway GO:0019221 9.5 IL1B IL10 CXCL8
5 neutrophil chemotaxis GO:0030593 9.46 IL1B CXCL8
6 leukocyte chemotaxis GO:0030595 9.26 IL10 CXCL8
7 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.16 IL1B IL10
8 cellular response to lipopolysaccharide GO:0071222 9.13 IL1B IL10 CXCL8
9 response to molecule of bacterial origin GO:0002237 8.62 IL10 CXCL8

Molecular functions related to Dermatitis, Atopic, 8 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 IL1B IL10 CXCL8
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Sources for Dermatitis, Atopic, 8

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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