Aliases & Classifications for Dermatographia

MalaCards integrated aliases for Dermatographia:

Name: Dermatographia 12 15
Dermatographic Urticaria 12 76
Dermographism 12 55
Symptomatic Dermographism 73

Classifications:



Summaries for Dermatographia

Disease Ontology : 12 An urticaria induced by stroking of the skin.

MalaCards based summary : Dermatographia, also known as dermatographic urticaria, is related to dermographism, familial and allergic conjunctivitis, and has symptoms including darier's sign and integumentary system signs and symptoms. An important gene associated with Dermatographia is OSMR (Oncostatin M Receptor), and among its related pathways/superpathways are Sphingolipid signaling pathway and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Cetirizine and Fexofenadine have been mentioned in the context of this disorder. Affiliated tissues include skin, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 76 Dermatographic urticaria (also known as dermographism, dermatographism or \"skin writing\") is a skin... more...

Related Diseases for Dermatographia

Diseases related to Dermatographia via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 dermographism, familial 11.7
2 allergic conjunctivitis 9.9
3 conjunctivitis 9.9
4 urticaria 9.7 FCER1A MS4A2
5 allergic hypersensitivity disease 9.4 FCER1A MS4A2
6 physical urticaria 9.3 FCER1A MS4A2 OSMR

Graphical network of the top 20 diseases related to Dermatographia:



Diseases related to Dermatographia

Symptoms & Phenotypes for Dermatographia

UMLS symptoms related to Dermatographia:


darier's sign, integumentary system signs and symptoms

GenomeRNAi Phenotypes related to Dermatographia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00381-A-1 9.17 MS4A2 SCARB2
2 Decreased viability GR00381-A-2 9.17 SCARB2
3 Decreased viability GR00381-A-3 9.17 MS4A2 SCARB2
4 Decreased viability GR00402-S-2 9.17 MS4A2 SCARB2

MGI Mouse Phenotypes related to Dermatographia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.35 CD36 FCER1A MS4A2 OSMR SCARB2
2 immune system MP:0005387 9.02 CD36 FCER1A MS4A2 OSMR SCARB2

Drugs & Therapeutics for Dermatographia

Drugs for Dermatographia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cetirizine Approved Phase 4 83881-51-0 2678
2
Fexofenadine Approved, Investigational Phase 4 83799-24-0 3348
3
Desloratadine Approved, Investigational Phase 4 100643-71-8 124087
4
Histamine Approved, Investigational Phase 4 75614-87-8, 51-45-6 774
5
Ebastine Approved, Investigational Phase 4 90729-43-4 3191
6
Histamine Phosphate Phase 4 51-74-1 65513
7 Cholinergic Agents Phase 4
8 Cholinergic Antagonists Phase 4
9 Neurotransmitter Agents Phase 4
10 Histamine Antagonists Phase 4,Phase 2
11 Histamine H1 Antagonists Phase 4,Phase 2
12 Histamine H1 Antagonists, Non-Sedating Phase 4
13 Anti-Allergic Agents Phase 4,Phase 2
14
Omalizumab Approved, Investigational Phase 2 242138-07-4
15 Respiratory System Agents Phase 2
16 Anti-Asthmatic Agents Phase 2
17 Antibodies Phase 2
18 Immunoglobulins Phase 2
19 Antibodies, Monoclonal Phase 2
20
Levocetirizine Approved 130018-77-8 1549000
21
Dinoprostone Approved 363-24-6 5280360
22
Serine Approved, Nutraceutical 56-45-1 5951

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of the Inhibitory Effect of 5 Anti-Histamines in Urticaria Completed NCT01940393 Phase 4 Cetirizine;Desloratadine;Fexofenadine;Ebastine;Bilastine
2 Bilastine Updosing in Chronic Spontaneous Urticaria Completed NCT02213367 Phase 3 Bilastine;Bilastine;Bilastin
3 Urticaria Facticia Treatment With Omalizumab (UFO) Completed NCT02169115 Phase 2 Omalizumab;Omalizumab;Placebo
4 Cold Urticaria Treatment With Xolair Completed NCT01580592 Phase 2 Omalizumab;Omalizumab;Placebo
5 Phase II Solar Urticaria (SU) Pilot Study Completed NCT00859534 Phase 2 afamelanotide
6 Cold Contact Urticaria Treatment With Rilonacept Active, not recruiting NCT02171416 Phase 2 Rilonacept;Placebo
7 Pathogenesis of Physical Induced Urticarial Syndromes Recruiting NCT00887939
8 The Effect of Levocetirizine on Inflammatory Mediators in Dermatographism Terminated NCT01008592 levocetirizine or placebo

Search NIH Clinical Center for Dermatographia

Genetic Tests for Dermatographia

Anatomical Context for Dermatographia

MalaCards organs/tissues related to Dermatographia:

41
Skin

Publications for Dermatographia

Articles related to Dermatographia:

# Title Authors Year
1
Symptomatic dermographism mimicking latex allergy. ( 24603512 )
2014
2
Papular dermatographia. ( 7451005 )
1980
3
Peculiarties in dermatology. Case reports. I. A case of dermatographia in an African patient. ( 5683138 )
1968
4
A case of allergic conjunctivitis with dermatographia. ( 14803111 )
1950

Variations for Dermatographia

Expression for Dermatographia

Search GEO for disease gene expression data for Dermatographia.

Pathways for Dermatographia

Pathways related to Dermatographia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.03 FCER1A MS4A2
2 10.69 CD36 FCER1A

GO Terms for Dermatographia

Cellular components related to Dermatographia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 8.8 CD36 FCER1A SCARB2

Biological processes related to Dermatographia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Fc-epsilon receptor signaling pathway GO:0038095 8.62 FCER1A MS4A2

Molecular functions related to Dermatographia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 scavenger receptor activity GO:0005044 8.96 CD36 SCARB2
2 IgE binding GO:0019863 8.62 FCER1A MS4A2

Sources for Dermatographia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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