Dermatographia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Dermatographia

MalaCards integrated aliases for Dermatographia:

Name: Dermatographia ¹² ¹⁵

Dermatographic Urticaria ¹² ⁷⁶

Dermographism ¹² ⁵⁵

Symptomatic Dermographism ⁷³

Classifications:

MalaCards categories:
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the skin and subcutaneous tissue

Urticaria and erythema

Urticaria

Dermatographic urticaria

External Ids:

Disease Ontology ¹² DOID:743

ICD10 ³³ L50.3

ICD9CM ³⁵ 708.3

NCIt ⁵⁰ C111885

SNOMED-CT ⁶⁸ 7632005

UMLS ⁷³ C0343065

Sources

Summaries for Dermatographia

Disease Ontology : ¹² An urticaria induced by stroking of the skin.

MalaCards based summary : Dermatographia, also known as dermatographic urticaria, is related to physical urticaria and dermographism, familial, and has symptoms including integumentary system signs and symptoms and darier's sign. An important gene associated with Dermatographia is OSMR (Oncostatin M Receptor), and among its related pathways/superpathways are Phospholipase D signaling pathway and Sphingolipid signaling pathway. The drugs Desloratadine and Ebastine have been mentioned in the context of this disorder. Affiliated tissues include skin and testes, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : ⁷⁶ Dermatographic urticaria (also known as dermographism, dermatographism or "skin writing") is a skin... more...

Sources

Related Diseases for Dermatographia

Diseases related to Dermatographia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 21)

#	Related Disease	Score	Top Affiliating Genes
1	physical urticaria	31.6	FCER1A MS4A2 OSMR
2	dermographism, familial	11.8
3	urticaria	10.5
4	mastocytosis, cutaneous	10.2
5	allergic conjunctivitis	10.1
6	conjunctivitis	10.1
7	cold urticaria	10.1
8	alopecia universalis congenita	9.9
9	alopecia	9.9
10	latex allergy	9.9
11	dermatomyositis	9.9
12	adult-onset still's disease	9.9
13	dermatitis	9.9
14	contact dermatitis	9.9
15	allergic contact dermatitis	9.9
16	cellulitis	9.9
17	mastocytosis	9.9
18	wells syndrome	9.9
19	chronic actinic dermatitis	9.9
20	fixed drug eruption	9.9
21	dermatitis, atopic	9.8	CDSN MS4A2

Graphical network of the top 20 diseases related to Dermatographia:

Sources

Symptoms & Phenotypes for Dermatographia

UMLS symptoms related to Dermatographia:

integumentary system signs and symptoms, darier's sign

GenomeRNAi Phenotypes related to Dermatographia according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00381-A-1	9.17	MS4A2 SCARB2
2	Decreased viability	GR00381-A-2	9.17	SCARB2
3	Decreased viability	GR00381-A-3	9.17	MS4A2 SCARB2
4	Decreased viability	GR00402-S-2	9.17	MS4A2 SCARB2

Sources

Drugs & Therapeutics for Dermatographia

Drugs for Dermatographia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Desloratadine

Approved, Investigational

Phase 4

100643-71-8

124087

2

Ebastine

Approved, Investigational

Phase 4

90729-43-4

3191

3

Histamine

Approved, Investigational

Phase 4

51-45-6, 75614-87-8

774

4

Fexofenadine

Approved, Investigational

Phase 4

83799-24-0

3348

5

Cetirizine

Approved

Phase 4

83881-51-0

2678

6

Histamine H1 Antagonists, Non-Sedating

Phase 4

7

Cholinergic Antagonists

Phase 4

8

Anti-Allergic Agents

Phase 4,Phase 2

9

Cholinergic Agents

Phase 4

10

Neurotransmitter Agents

Phase 4

11

Histamine H1 Antagonists

Phase 4,Phase 2

12

Histamine Phosphate

Phase 4

51-74-1

65513

13

Histamine Antagonists

Phase 4,Phase 2

14

Omalizumab

Approved, Investigational

Phase 2

242138-07-4

15

Anti-Asthmatic Agents

Phase 2

16

Immunologic Factors

Phase 2

17

Antibodies, Monoclonal

Phase 2

18

Antibodies

Phase 2

19

Respiratory System Agents

Phase 2

20

Immunoglobulins

Phase 2

21

Levocetirizine

Approved

130018-77-8

1549000

22

Dinoprostone

Approved

363-24-6

5280360

23

Serine

Approved, Nutraceutical

56-45-1

5951

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Evaluation of the Inhibitory Effect of 5 Anti-Histamines in Urticaria	Completed	NCT01940393	Phase 4	Cetirizine;Desloratadine;Fexofenadine;Ebastine;Bilastine
2	Bilastine Updosing in Chronic Spontaneous Urticaria	Completed	NCT02213367	Phase 3	Bilastine;Bilastine;Bilastin
3	Urticaria Facticia Treatment With Omalizumab (UFO)	Completed	NCT02169115	Phase 2	Omalizumab;Omalizumab;Placebo
4	Cold Urticaria Treatment With Xolair	Completed	NCT01580592	Phase 2	Omalizumab;Omalizumab;Placebo
5	Cold Contact Urticaria Treatment With Rilonacept	Completed	NCT02171416	Phase 2	Rilonacept;Placebo
6	Phase II Solar Urticaria (SU) Pilot Study	Completed	NCT00859534	Phase 2	afamelanotide
7	Pathogenesis of Physical Induced Urticarial Syndromes	Recruiting	NCT00887939
8	Electroacupuncture Frequency-related Effects on Non-specific Low Back Pain in Older Adults.	Recruiting	NCT03802045	Not Applicable
9	The Effect of Levocetirizine on Inflammatory Mediators in Dermatographism	Terminated	NCT01008592		levocetirizine or placebo

Search NIH Clinical Center for Dermatographia

Sources

Genetic Tests for Dermatographia

Sources

Anatomical Context for Dermatographia

MalaCards organs/tissues related to Dermatographia:

⁴¹

Skin, Testes

Sources

Publications for Dermatographia

Articles related to Dermatographia:

(show all 23)

#	Title	Authors	Year
1	Omalizumab is effective in symptomatic dermographism-results of a randomized placebo-controlled trial. ( 28389391 )	Maurer M...Metz M	2017
2	Brain-derived neurotrophic factor is increased in serum levels of patients with symptomatic dermographism. ( 28951710 )	Erpolat S...Bozkurt B	2017
3	Symptomatic dermographism: an inadequately described disease. ( 25174372 )	Schoepke N...Maurer M	2015
4	Validation of a simplified provocation instrument for diagnosis and threshold testing of symptomatic dermographism. ( 25522055 )	Schoepke N...Magerl M	2015
5	Feasibility and Utility of the Fric Test in Symptomatic Dermographism: A Pilot Study. ( 26677310 )	Mehta A...Patil S	2015
6	Symptomatic dermographism mimicking latex allergy. ( 24603512 )	Golberg O....Wilkinson M.	2014
7	A novel, simple, validated and reproducible instrument for assessing provocation threshold levels in patients with symptomatic dermographism. ( 23621090 )	Mlynek A...Maurer M	2013
8	Dermatomyositis presenting with symptomatic dermographism and raised troponin T: a case report. ( 19830184 )	Rahim KF...Dawe RS	2009
9	Narrowband ultraviolet B phototherapy is beneficial in antihistamine-resistant symptomatic dermographism: a pilot study. ( 18774200 )	Borzova E...Grattan CE	2008
10	Evaluation of patients with symptomatic dermographism. ( 16405609 )	Ta?kapan O...Harmanyeri Y	2006
11	Congenital symptomatic dermographism as the first symptom of mastocytosis. ( 11069538 )	Grimm V...Abeck D	2000
12	Dyspareunia and vulvodynia: unrecognised manifestations of symptomatic dermographism. ( 8988122 )	Lambiris A...Greaves MW	1997
13	Acrivastine versus terfenadine in the treatment of symptomatic dermographism--a double-blind, placebo-controlled study. ( 2570004 )	Boyle J...Gibson JR	1989
14	Symptomatic dermographism: wealing, mast cells and histamine are decreased in the skin following long-term application of a potent topical corticosteroid. ( 2597634 )	Lawlor F...Greaves MW	1989
15	The effect of psoralen photochemotherapy (PUVA) on symptomatic dermographism. ( 2680176 )	Logan RA...Greaves MW	1989
16	Calcium antagonist in the treatment of symptomatic dermographism. Low-dose and high-dose studies with nifedipine. ( 3072223 )	Lawlor F...Greaves MW	1988
17	Symptomatic dermographism (factitious urticaria)--passive transfer experiments from human to monkey. ( 3620341 )	Murphy GM...Winkelmann RK	1987
18	Symptomatic dermographism: natural history, clinical features laboratory investigations and response to therapy. ( 6139191 )	Breathnach SM...Greaves MW	1983
19	Symptomatic dermographism. ( 6118390 )	Margolis CF...Estes SA	1981
20	Papular dermatographia. ( 7451005 )	Burkhart C.G.	1980
21	The effect of H1 and H2 histamine antagonists on symptomatic dermographism. ( 475988 )	Matthews CN...Storari F	1979
22	Peculiarties in dermatology. Case reports. I. A case of dermatographia in an African patient. ( 5683138 )	Kingsley HJ	1968
23	A case of allergic conjunctivitis with dermatographia. ( 14803111 )	Pal D.	1950

Sources

Genes for Dermatographia

Genes related to Dermatographia (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	OSMR	Oncostatin M Receptor	Protein Coding	15.79	DISEASES inferred ¹⁵
2	CDSN	Corneodesmosin	Protein Coding	15.37	DISEASES inferred ¹⁵
3	ZBTB22	Zinc Finger And BTB Domain Containing 22	Protein Coding	14.91	DISEASES inferred ¹⁵
4	MS4A2	Membrane Spanning 4-Domains A2	Protein Coding	14.89	DISEASES inferred ¹⁵
5	FCER1A	Fc Fragment Of IgE Receptor Ia	Protein Coding	14.88	DISEASES inferred ¹⁵
6	SCARB2	Scavenger Receptor Class B Member 2	Protein Coding	14.8	DISEASES inferred ¹⁵

Sources

Variations for Dermatographia

Sources

Expression for Dermatographia

Search GEO for disease gene expression data for Dermatographia.

Sources

Pathways for Dermatographia

Pathways related to Dermatographia according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Phospholipase D signaling pathway ³⁷ Show member pathways Choline metabolism in cancer ³⁷	11.34	FCER1A MS4A2
2	Sphingolipid signaling pathway ³⁷	10.7	FCER1A MS4A2

Sources

GO Terms for Dermatographia

Biological processes related to Dermatographia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	Fc-epsilon receptor signaling pathway	GO:0038095	8.62	FCER1A MS4A2

Molecular functions related to Dermatographia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	IgE binding	GO:0019863	8.62	FCER1A MS4A2

Sources

Sources for Dermatographia

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia