Aliases & Classifications for Dermatographia

MalaCards integrated aliases for Dermatographia:

Name: Dermatographia 12 15 17
Dermatographic Urticaria 12 77
Dermographism 12 56
Symptomatic Dermographism 74

Classifications:



External Ids:

Disease Ontology 12 DOID:743
ICD9CM 36 708.3
NCIt 51 C111885
SNOMED-CT 69 7632005
ICD10 34 L50.3
UMLS 74 C0343065

Summaries for Dermatographia

Disease Ontology : 12 An urticaria induced by stroking of the skin.

MalaCards based summary : Dermatographia, also known as dermatographic urticaria, is related to physical urticaria and dermographism, familial, and has symptoms including integumentary system signs and symptoms and darier's sign. An important gene associated with Dermatographia is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways is Sphingolipid signaling pathway. The drugs Fexofenadine and Ebastine have been mentioned in the context of this disorder. Affiliated tissues include skin and testes, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 77 Dermatographic urticaria is a skin disorder and one of the most common types of urticaria, affecting... more...

Related Diseases for Dermatographia

Diseases related to Dermatographia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 22)
# Related Disease Score Top Affiliating Genes
1 physical urticaria 31.6 FCER1A MS4A2
2 dermographism, familial 11.9
3 urticaria 10.6
4 mastocytosis, cutaneous 10.2
5 allergic conjunctivitis 10.1
6 conjunctivitis 10.1
7 mastocytosis 10.1
8 cold urticaria 10.1
9 ige responsiveness, atopic 10.0
10 alopecia universalis congenita 10.0
11 alopecia 10.0
12 systemic scleroderma 10.0
13 latex allergy 10.0
14 dermatomyositis 10.0
15 adult-onset still's disease 10.0
16 dermatitis 10.0
17 contact dermatitis 10.0
18 allergic contact dermatitis 10.0
19 cellulitis 10.0
20 wells syndrome 10.0
21 chronic actinic dermatitis 10.0
22 fixed drug eruption 10.0

Graphical network of the top 20 diseases related to Dermatographia:



Diseases related to Dermatographia

Symptoms & Phenotypes for Dermatographia

UMLS symptoms related to Dermatographia:


integumentary system signs and symptoms, darier's sign

GenomeRNAi Phenotypes related to Dermatographia according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00381-A-1 9.17 MS4A2 SCARB2
2 Decreased viability GR00381-A-2 9.17 SCARB2
3 Decreased viability GR00381-A-3 9.17 MS4A2 SCARB2
4 Decreased viability GR00402-S-2 9.17 MS4A2 SCARB2

Drugs & Therapeutics for Dermatographia

Drugs for Dermatographia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fexofenadine Approved, Investigational Phase 4 83799-24-0 3348
2
Ebastine Approved, Investigational Phase 4 90729-43-4 3191
3
Desloratadine Approved, Investigational Phase 4 100643-71-8 124087
4
Histamine Approved, Investigational Phase 4 51-45-6 774
5
Cetirizine Approved Phase 4 83881-51-0 2678
6 Histamine H1 Antagonists Phase 4,Phase 2
7 Histamine Antagonists Phase 4,Phase 2
8 Cholinergic Antagonists Phase 4
9
Histamine Phosphate Phase 4 51-74-1 65513
10 Anti-Allergic Agents Phase 4,Phase 2
11 Cholinergic Agents Phase 4
12 Histamine H1 Antagonists, Non-Sedating Phase 4
13 Neurotransmitter Agents Phase 4
14
Omalizumab Approved, Investigational Phase 2 242138-07-4
15
Rilonacept Approved, Investigational Phase 2 501081-76-1 104924
16
Afamelanotide Experimental, Investigational Phase 2 75921-69-6
17 Immunoglobulins Phase 2
18 Respiratory System Agents Phase 2
19 Anti-Asthmatic Agents Phase 2
20 Antibodies, Monoclonal Phase 2
21 Immunologic Factors Phase 2
22 Antibodies Phase 2
23 Anti-Inflammatory Agents Phase 2
24 Dermatologic Agents Phase 2
25
Ethanol Approved Not Applicable 64-17-5 702
26
Dinoprostone Approved 363-24-6 5280360
27
Levocetirizine Approved 130018-77-8 1549000
28
Serine Approved, Nutraceutical 56-45-1 5951

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of the Inhibitory Effect of 5 Anti-Histamines in Urticaria Completed NCT01940393 Phase 4 Cetirizine;Desloratadine;Fexofenadine;Ebastine;Bilastine
2 Bilastine Updosing in Chronic Spontaneous Urticaria Completed NCT02213367 Phase 3 Bilastine;Bilastine;Bilastin
3 Urticaria Facticia Treatment With Omalizumab (UFO) Completed NCT02169115 Phase 2 Omalizumab;Omalizumab;Placebo
4 Cold Urticaria Treatment With Xolair Completed NCT01580592 Phase 2 Omalizumab;Omalizumab;Placebo
5 Cold Contact Urticaria Treatment With Rilonacept Completed NCT02171416 Phase 2 Rilonacept;Placebo
6 Phase II Solar Urticaria (SU) Pilot Study Completed NCT00859534 Phase 2 afamelanotide
7 Pathogenesis of Physical Induced Urticarial Syndromes Recruiting NCT00887939
8 Electroacupuncture Frequency-related Effects on Non-specific Low Back Pain in Older Adults. Recruiting NCT03802045 Not Applicable
9 Biomarkers for the Detection of Lymphatic Insufficiency Enrolling by invitation NCT02375165
10 The Effect of Levocetirizine on Inflammatory Mediators in Dermatographism Terminated NCT01008592 levocetirizine or placebo

Search NIH Clinical Center for Dermatographia

Genetic Tests for Dermatographia

Anatomical Context for Dermatographia

MalaCards organs/tissues related to Dermatographia:

42
Skin, Testes

Publications for Dermatographia

Articles related to Dermatographia:

(show all 23)
# Title Authors Year
1
Omalizumab is effective in symptomatic dermographism-results of a randomized placebo-controlled trial. ( 28389391 )
2017
2
Brain-derived neurotrophic factor is increased in serum levels of patients with symptomatic dermographism. ( 28951710 )
2017
3
Symptomatic dermographism: an inadequately described disease. ( 25174372 )
2015
4
Validation of a simplified provocation instrument for diagnosis and threshold testing of symptomatic dermographism. ( 25522055 )
2015
5
Feasibility and Utility of the Fric Test in Symptomatic Dermographism: A Pilot Study. ( 26677310 )
2015
6
Symptomatic dermographism mimicking latex allergy. ( 24603512 )
2014
7
A novel, simple, validated and reproducible instrument for assessing provocation threshold levels in patients with symptomatic dermographism. ( 23621090 )
2013
8
Dermatomyositis presenting with symptomatic dermographism and raised troponin T: a case report. ( 19830184 )
2009
9
Narrowband ultraviolet B phototherapy is beneficial in antihistamine-resistant symptomatic dermographism: a pilot study. ( 18774200 )
2008
10
Evaluation of patients with symptomatic dermographism. ( 16405609 )
2006
11
Congenital symptomatic dermographism as the first symptom of mastocytosis. ( 11069538 )
2000
12
Dyspareunia and vulvodynia: unrecognised manifestations of symptomatic dermographism. ( 8988122 )
1997
13
Acrivastine versus terfenadine in the treatment of symptomatic dermographism--a double-blind, placebo-controlled study. ( 2570004 )
1989
14
Symptomatic dermographism: wealing, mast cells and histamine are decreased in the skin following long-term application of a potent topical corticosteroid. ( 2597634 )
1989
15
The effect of psoralen photochemotherapy (PUVA) on symptomatic dermographism. ( 2680176 )
1989
16
Calcium antagonist in the treatment of symptomatic dermographism. Low-dose and high-dose studies with nifedipine. ( 3072223 )
1988
17
Symptomatic dermographism (factitious urticaria)--passive transfer experiments from human to monkey. ( 3620341 )
1987
18
Symptomatic dermographism: natural history, clinical features laboratory investigations and response to therapy. ( 6139191 )
1983
19
Symptomatic dermographism. ( 6118390 )
1981
20
Papular dermatographia. ( 7451005 )
1980
21
The effect of H1 and H2 histamine antagonists on symptomatic dermographism. ( 475988 )
1979
22
Peculiarties in dermatology. Case reports. I. A case of dermatographia in an African patient. ( 5683138 )
1968
23
A case of allergic conjunctivitis with dermatographia. ( 14803111 )
1950

Variations for Dermatographia

Expression for Dermatographia

Search GEO for disease gene expression data for Dermatographia.

Pathways for Dermatographia

Pathways related to Dermatographia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.7 FCER1A MS4A2

GO Terms for Dermatographia

Cellular components related to Dermatographia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 8.62 CCR6 FCER1A

Biological processes related to Dermatographia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Fc-epsilon receptor signaling pathway GO:0038095 8.62 FCER1A MS4A2

Molecular functions related to Dermatographia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 IgE binding GO:0019863 8.62 FCER1A MS4A2

Sources for Dermatographia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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