Dermatographia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Dermatographia

MalaCards integrated aliases for Dermatographia:

Name: Dermatographia ¹² ¹⁵ ¹⁷

Dermatographic Urticaria ¹² ⁷⁷

Dermographism ¹² ⁵⁶

Symptomatic Dermographism ⁷⁴

Classifications:

MalaCards categories:
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴

Diseases of the skin and subcutaneous tissue

Urticaria and erythema

Urticaria

Dermatographic urticaria

External Ids:

Disease Ontology ¹² DOID:743

ICD9CM ³⁶ 708.3

NCIt ⁵¹ C111885

SNOMED-CT ⁶⁹ 7632005

ICD10 ³⁴ L50.3

EFO ¹⁷ EFO_1000685

UMLS ⁷⁴ C0343065

Sources

Summaries for Dermatographia

Disease Ontology : ¹² An urticaria induced by stroking of the skin.

MalaCards based summary : Dermatographia, also known as dermatographic urticaria, is related to physical urticaria and dermographism, familial, and has symptoms including integumentary system signs and symptoms and darier's sign. An important gene associated with Dermatographia is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways is Sphingolipid signaling pathway. The drugs Fexofenadine and Cetirizine have been mentioned in the context of this disorder. Affiliated tissues include skin and testes, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : ⁷⁷ Dermatographic urticaria (also known as dermographism, dermatographism or "skin writing") is a skin... more...

Sources

Related Diseases for Dermatographia

Diseases related to Dermatographia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 23)

#	Related Disease	Score	Top Affiliating Genes
1	physical urticaria	31.5	FCER1A MS4A2
2	dermographism, familial	11.8
3	urticaria	10.6
4	mastocytosis, cutaneous	10.2
5	allergic conjunctivitis	10.1
6	conjunctivitis	10.1
7	mastocytosis	10.1
8	cold urticaria	10.1
9	ige responsiveness, atopic	9.9
10	alopecia universalis congenita	9.9
11	alopecia	9.9
12	systemic scleroderma	9.9
13	latex allergy	9.9
14	dermatomyositis	9.9
15	brucellosis	9.9
16	adult-onset still's disease	9.9
17	dermatitis	9.9
18	contact dermatitis	9.9
19	allergic contact dermatitis	9.9
20	cellulitis	9.9
21	wells syndrome	9.9
22	chronic actinic dermatitis	9.9
23	fixed drug eruption	9.9

Graphical network of the top 20 diseases related to Dermatographia:

Sources

Symptoms & Phenotypes for Dermatographia

UMLS symptoms related to Dermatographia:

integumentary system signs and symptoms, darier's sign

GenomeRNAi Phenotypes related to Dermatographia according to GeneCards Suite gene sharing:

²⁷

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00381-A-1	9.17	MS4A2 SCARB2
2	Decreased viability	GR00381-A-2	9.17	SCARB2
3	Decreased viability	GR00381-A-3	9.17	MS4A2 SCARB2
4	Decreased viability	GR00402-S-2	9.17	MS4A2 SCARB2

Sources

Drugs & Therapeutics for Dermatographia

Drugs for Dermatographia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Fexofenadine

Approved, Investigational

Phase 4

83799-24-0

3348

2

Cetirizine

Approved

Phase 4

83881-51-0

2678

3

Ebastine

Approved, Investigational

Phase 4

90729-43-4

3191

4

Desloratadine

Approved, Investigational

Phase 4

100643-71-8

124087

5

Histamine

Approved, Investigational

Phase 4

51-45-6

774

6

Histamine Phosphate

Phase 4

51-74-1

65513

7

Anti-Allergic Agents

Phase 4,Phase 2

8

Cholinergic Agents

Phase 4

9

Cholinergic Antagonists

Phase 4

10

Neurotransmitter Agents

Phase 4

11

Histamine H1 Antagonists

Phase 4,Phase 2

12

Histamine H1 Antagonists, Non-Sedating

Phase 4

13

Histamine Antagonists

Phase 4,Phase 2

14

Omalizumab

Approved, Investigational

Phase 2

242138-07-4

15

Rilonacept

Approved, Investigational

Phase 2

501081-76-1

104924

16

Afamelanotide

Experimental, Investigational

Phase 2

75921-69-6

17

Respiratory System Agents

Phase 2

18

Immunologic Factors

Phase 2

19

Antibodies

Phase 2

20

Antibodies, Monoclonal

Phase 2

21

Anti-Asthmatic Agents

Phase 2

22

Immunoglobulins

Phase 2

23

Anti-Inflammatory Agents

Phase 2

24

Dermatologic Agents

Phase 2

25

Ethanol

Approved

Not Applicable

64-17-5

702

26

Levocetirizine

Approved

130018-77-8

1549000

27

Dinoprostone

Approved

363-24-6

5280360

28

Serine

Approved, Nutraceutical

56-45-1

5951

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Evaluation of the Inhibitory Effect of 5 Anti-Histamines in Urticaria	Completed	NCT01940393	Phase 4	Cetirizine;Desloratadine;Fexofenadine;Ebastine;Bilastine
2	Bilastine Updosing in Chronic Spontaneous Urticaria	Completed	NCT02213367	Phase 3	Bilastine;Bilastine;Bilastin
3	Urticaria Facticia Treatment With Omalizumab (UFO)	Completed	NCT02169115	Phase 2	Omalizumab;Omalizumab;Placebo
4	Cold Urticaria Treatment With Xolair	Completed	NCT01580592	Phase 2	Omalizumab;Omalizumab;Placebo
5	Cold Contact Urticaria Treatment With Rilonacept	Completed	NCT02171416	Phase 2	Rilonacept;Placebo
6	Phase II Solar Urticaria (SU) Pilot Study	Completed	NCT00859534	Phase 2	afamelanotide
7	Pathogenesis of Physical Induced Urticarial Syndromes	Recruiting	NCT00887939
8	Electroacupuncture Frequency-related Effects on Non-specific Low Back Pain in Older Adults.	Recruiting	NCT03802045	Not Applicable
9	The Effect of Levocetirizine on Inflammatory Mediators in Dermatographism	Terminated	NCT01008592		levocetirizine or placebo

Search NIH Clinical Center for Dermatographia

Sources

Genetic Tests for Dermatographia

Sources

Anatomical Context for Dermatographia

MalaCards organs/tissues related to Dermatographia:

⁴²

Skin, Testes

Sources

Publications for Dermatographia

Articles related to Dermatographia:

(show all 23)

#	Title	Authors	Year
1	Omalizumab is effective in symptomatic dermographism-results of a randomized placebo-controlled trial. ( 28389391 )	Maurer M...Metz M	2017
2	Brain-derived neurotrophic factor is increased in serum levels of patients with symptomatic dermographism. ( 28951710 )	Erpolat S...Bozkurt B	2017
3	Symptomatic dermographism: an inadequately described disease. ( 25174372 )	Schoepke N...Maurer M	2015
4	Validation of a simplified provocation instrument for diagnosis and threshold testing of symptomatic dermographism. ( 25522055 )	Schoepke N...Magerl M	2015
5	Feasibility and Utility of the Fric Test in Symptomatic Dermographism: A Pilot Study. ( 26677310 )	Mehta A...Patil S	2015
6	Symptomatic dermographism mimicking latex allergy. ( 24603512 )	Golberg O....Wilkinson M.	2014
7	A novel, simple, validated and reproducible instrument for assessing provocation threshold levels in patients with symptomatic dermographism. ( 23621090 )	Mlynek A...Maurer M	2013
8	Dermatomyositis presenting with symptomatic dermographism and raised troponin T: a case report. ( 19830184 )	Rahim KF...Dawe RS	2009
9	Narrowband ultraviolet B phototherapy is beneficial in antihistamine-resistant symptomatic dermographism: a pilot study. ( 18774200 )	Borzova E...Grattan CE	2008
10	Evaluation of patients with symptomatic dermographism. ( 16405609 )	Ta?kapan O...Harmanyeri Y	2006
11	Congenital symptomatic dermographism as the first symptom of mastocytosis. ( 11069538 )	Grimm V...Abeck D	2000
12	Dyspareunia and vulvodynia: unrecognised manifestations of symptomatic dermographism. ( 8988122 )	Lambiris A...Greaves MW	1997
13	Acrivastine versus terfenadine in the treatment of symptomatic dermographism--a double-blind, placebo-controlled study. ( 2570004 )	Boyle J...Gibson JR	1989
14	Symptomatic dermographism: wealing, mast cells and histamine are decreased in the skin following long-term application of a potent topical corticosteroid. ( 2597634 )	Lawlor F...Greaves MW	1989
15	The effect of psoralen photochemotherapy (PUVA) on symptomatic dermographism. ( 2680176 )	Logan RA...Greaves MW	1989
16	Calcium antagonist in the treatment of symptomatic dermographism. Low-dose and high-dose studies with nifedipine. ( 3072223 )	Lawlor F...Greaves MW	1988
17	Symptomatic dermographism (factitious urticaria)--passive transfer experiments from human to monkey. ( 3620341 )	Murphy GM...Winkelmann RK	1987
18	Symptomatic dermographism: natural history, clinical features laboratory investigations and response to therapy. ( 6139191 )	Breathnach SM...Greaves MW	1983
19	Symptomatic dermographism. ( 6118390 )	Margolis CF...Estes SA	1981
20	Papular dermatographia. ( 7451005 )	Burkhart C.G.	1980
21	The effect of H1 and H2 histamine antagonists on symptomatic dermographism. ( 475988 )	Matthews CN...Storari F	1979
22	Peculiarties in dermatology. Case reports. I. A case of dermatographia in an African patient. ( 5683138 )	KINGSLEY H.J.	1968
23	A case of allergic conjunctivitis with dermatographia. ( 14803111 )	Pal D.	1950

Sources

Genes for Dermatographia

Genes related to Dermatographia (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	18.14	DISEASES inferred ¹⁵ ¹⁵
2	CDSN	Corneodesmosin	Protein Coding	15.33	DISEASES inferred ¹⁵
3	SCARB2	Scavenger Receptor Class B Member 2	Protein Coding	14.97	DISEASES inferred ¹⁵
4	ZBTB22	Zinc Finger And BTB Domain Containing 22	Protein Coding	14.85	DISEASES inferred ¹⁵
5	FCER1A	Fc Fragment Of IgE Receptor Ia	Protein Coding	14.84	DISEASES inferred ¹⁵
6	MS4A2	Membrane Spanning 4-Domains A2	Protein Coding	14.84	DISEASES inferred ¹⁵

Sources

Variations for Dermatographia

Sources

Expression for Dermatographia

Search GEO for disease gene expression data for Dermatographia.

Sources

Pathways for Dermatographia

Pathways related to Dermatographia according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Sphingolipid signaling pathway ³⁸	10.7	FCER1A MS4A2

Sources

GO Terms for Dermatographia

Cellular components related to Dermatographia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell surface	GO:0009986	8.62	CCR6 FCER1A

Biological processes related to Dermatographia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	Fc-epsilon receptor signaling pathway	GO:0038095	8.62	FCER1A MS4A2

Molecular functions related to Dermatographia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	IgE binding	GO:0019863	8.62	FCER1A MS4A2

Sources

Sources for Dermatographia

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia