Dermatographia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Dermatographia

MalaCards integrated aliases for Dermatographia:

Name: Dermatographia ¹² ¹⁵

Dermatographic Urticaria ¹² ⁷⁶

Dermographism ¹² ⁵⁵

Symptomatic Dermographism ⁷³

Classifications:

MalaCards categories:
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the skin and subcutaneous tissue

Urticaria and erythema

Urticaria

Dermatographic urticaria

External Ids:

Disease Ontology ¹² DOID:743

ICD10 ³³ L50.3

ICD9CM ³⁵ 708.3

NCIt ⁵⁰ C111885

SNOMED-CT ⁶⁸ 123093003 156430003 201263000 more

UMLS ⁷³ C0343065

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Summaries for Dermatographia

Disease Ontology : ¹² An urticaria induced by stroking of the skin.

MalaCards based summary : Dermatographia, also known as dermatographic urticaria, is related to dermographism, familial and allergic conjunctivitis, and has symptoms including darier's sign and integumentary system signs and symptoms. An important gene associated with Dermatographia is OSMR (Oncostatin M Receptor), and among its related pathways/superpathways are Sphingolipid signaling pathway and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Cetirizine and Fexofenadine have been mentioned in the context of this disorder. Affiliated tissues include skin, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : ⁷⁶ Dermatographic urticaria (also known as dermographism, dermatographism or \"skin writing\") is a skin... more...

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Related Diseases for Dermatographia

Diseases related to Dermatographia via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	dermographism, familial	11.7
2	allergic conjunctivitis	9.9
3	conjunctivitis	9.9
4	urticaria	9.7	FCER1A MS4A2
5	allergic hypersensitivity disease	9.4	FCER1A MS4A2
6	physical urticaria	9.3	FCER1A MS4A2 OSMR

Graphical network of the top 20 diseases related to Dermatographia:

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Symptoms & Phenotypes for Dermatographia

UMLS symptoms related to Dermatographia:

darier's sign, integumentary system signs and symptoms

GenomeRNAi Phenotypes related to Dermatographia according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00381-A-1	9.17	MS4A2 SCARB2
2	Decreased viability	GR00381-A-2	9.17	SCARB2
3	Decreased viability	GR00381-A-3	9.17	MS4A2 SCARB2
4	Decreased viability	GR00402-S-2	9.17	MS4A2 SCARB2

MGI Mouse Phenotypes related to Dermatographia:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	9.35	CD36 FCER1A MS4A2 OSMR SCARB2
2	immune system	MP:0005387	9.02	CD36 FCER1A MS4A2 OSMR SCARB2

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Drugs & Therapeutics for Dermatographia

Drugs for Dermatographia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Cetirizine

Approved

Phase 4

83881-51-0

2678

2

Fexofenadine

Approved, Investigational

Phase 4

83799-24-0

3348

3

Desloratadine

Approved, Investigational

Phase 4

100643-71-8

124087

4

Histamine

Approved, Investigational

Phase 4

75614-87-8, 51-45-6

774

5

Ebastine

Approved, Investigational

Phase 4

90729-43-4

3191

6

Histamine Phosphate

Phase 4

51-74-1

65513

7

Cholinergic Agents

Phase 4

8

Cholinergic Antagonists

Phase 4

9

Neurotransmitter Agents

Phase 4

10

Histamine Antagonists

Phase 4,Phase 2

11

Histamine H1 Antagonists

Phase 4,Phase 2

12

Histamine H1 Antagonists, Non-Sedating

Phase 4

13

Anti-Allergic Agents

Phase 4,Phase 2

14

Omalizumab

Approved, Investigational

Phase 2

242138-07-4

15

Respiratory System Agents

Phase 2

16

Anti-Asthmatic Agents

Phase 2

17

Antibodies

Phase 2

18

Immunoglobulins

Phase 2

19

Antibodies, Monoclonal

Phase 2

20

Levocetirizine

Approved

130018-77-8

1549000

21

Dinoprostone

Approved

363-24-6

5280360

22

Serine

Approved, Nutraceutical

56-45-1

5951

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Evaluation of the Inhibitory Effect of 5 Anti-Histamines in Urticaria	Completed	NCT01940393	Phase 4	Cetirizine;Desloratadine;Fexofenadine;Ebastine;Bilastine
2	Bilastine Updosing in Chronic Spontaneous Urticaria	Completed	NCT02213367	Phase 3	Bilastine;Bilastine;Bilastin
3	Urticaria Facticia Treatment With Omalizumab (UFO)	Completed	NCT02169115	Phase 2	Omalizumab;Omalizumab;Placebo
4	Cold Urticaria Treatment With Xolair	Completed	NCT01580592	Phase 2	Omalizumab;Omalizumab;Placebo
5	Phase II Solar Urticaria (SU) Pilot Study	Completed	NCT00859534	Phase 2	afamelanotide
6	Cold Contact Urticaria Treatment With Rilonacept	Active, not recruiting	NCT02171416	Phase 2	Rilonacept;Placebo
7	Pathogenesis of Physical Induced Urticarial Syndromes	Recruiting	NCT00887939
8	The Effect of Levocetirizine on Inflammatory Mediators in Dermatographism	Terminated	NCT01008592		levocetirizine or placebo

Search NIH Clinical Center for Dermatographia

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Genetic Tests for Dermatographia

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Anatomical Context for Dermatographia

MalaCards organs/tissues related to Dermatographia:

⁴¹

Skin

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Publications for Dermatographia

Articles related to Dermatographia:

#	Title	Authors	Year
1	Symptomatic dermographism mimicking latex allergy. ( 24603512 )	Golberg O....Wilkinson M.	2014
2	Papular dermatographia. ( 7451005 )	Burkhart C.G.	1980
3	Peculiarties in dermatology. Case reports. I. A case of dermatographia in an African patient. ( 5683138 )	KINGSLEY H.J.	1968
4	A case of allergic conjunctivitis with dermatographia. ( 14803111 )	Pal D.	1950

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Genes for Dermatographia

Genes related to Dermatographia (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	OSMR	Oncostatin M Receptor	Protein Coding	15.84	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	FCER1A	Fc Fragment Of IgE Receptor Ia	Protein Coding	15.06	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	MS4A2	Membrane Spanning 4-Domains A2	Protein Coding	14.93	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	ZBTB22	Zinc Finger And BTB Domain Containing 22	Protein Coding	14.92	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	SCARB2	Scavenger Receptor Class B Member 2	Protein Coding	14.79	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	CD36	CD36 Molecule	Protein Coding	14.61	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)

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Variations for Dermatographia

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Expression for Dermatographia

Search GEO for disease gene expression data for Dermatographia.

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Pathways for Dermatographia

Pathways related to Dermatographia according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Sphingolipid signaling pathway ³⁷	11.03	FCER1A MS4A2
2	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	10.69	CD36 FCER1A

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GO Terms for Dermatographia

Cellular components related to Dermatographia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell surface	GO:0009986	8.8	CD36 FCER1A SCARB2

Biological processes related to Dermatographia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	Fc-epsilon receptor signaling pathway	GO:0038095	8.62	FCER1A MS4A2

Molecular functions related to Dermatographia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	scavenger receptor activity	GO:0005044	8.96	CD36 SCARB2
2	IgE binding	GO:0019863	8.62	FCER1A MS4A2

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Sources for Dermatographia

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia