MCID: DRM009
MIFTS: 36

Dermatomycosis

Categories: Infectious diseases, Skin diseases

Aliases & Classifications for Dermatomycosis

MalaCards integrated aliases for Dermatomycosis:

Name: Dermatomycosis 12 15
Dermatomycoses 43 71

Classifications:



External Ids:

Disease Ontology 12 DOID:1563
ICD9CM 34 111.9
MeSH 43 D003881
SNOMED-CT 67 14560005
UMLS 71 C0011630

Summaries for Dermatomycosis

Disease Ontology : 12 A cutaneous mycosis that results in fungal infection located in skin or of its appendages, has material basis in Ascomycota fungi other than the dermatophytes.

MalaCards based summary : Dermatomycosis, also known as dermatomycoses, is related to superficial mycosis and lobomycosis. An important gene associated with Dermatomycosis is POLR2B (RNA Polymerase II Subunit B). The drugs Amorolfine and Ciclopirox have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and t cells.

Wikipedia : 74 A dermatomycosis is a skin disease caused by a fungus. This excludes... more...

Related Diseases for Dermatomycosis

Diseases related to Dermatomycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 115)
# Related Disease Score Top Affiliating Genes
1 superficial mycosis 31.8 POLR2B CLEC7A CBSL B4GALNT2
2 lobomycosis 31.6 CR2 CD4
3 tinea corporis 31.3 CBSL B4GALNT2
4 tinea capitis 31.1 CBSL B4GALNT2
5 tinea unguium 31.0 CBSL B4GALNT2
6 pityriasis versicolor 30.9 CLEC7A CBSL
7 tinea cruris 30.8 CYP51A1 CBSL B4GALNT2
8 chromoblastomycosis 30.6 CLEC7A CBSL
9 tinea pedis 30.6 CYP51A1 CLEC7A CBSL B4GALNT2
10 tinea manuum 30.5 CBSL B4GALNT2
11 tinea nigra 30.5 POLR2B CBSL
12 otomycosis 30.4 POLR2B CBSL B4GALNT2
13 cutaneous candidiasis 30.4 CLEC7A B4GALNT2
14 dermatophytosis 30.1 POLR2B CYP51A1 CLEC7A CD4 CBSL B4GALNT2
15 sporotrichosis 29.9 CLEC7A CD4 CBSL
16 cryptococcosis 29.9 CLEC7A CD4
17 histoplasmosis 29.8 CLEC7A CD4
18 eumycotic mycetoma 29.8 TPT1 POLR2B IL37 HAND1 CYP51A1 CBSL
19 white piedra 29.8 POLR2B CLEC7A CBSL B4GALNT2
20 fungal infectious disease 29.8 CYP51A1 CLEC7A CD4 CBSL B4GALNT2
21 coccidioidomycosis 29.8 CYP51A1 CLEC7A CD4
22 nail disease 29.8 CLEC7A CD4
23 mucormycosis 29.5 CYP51A1 CLEC7A CD4 B4GALNT2
24 candidiasis 10.5
25 noonan syndrome 8 10.3 POLR2B CBSL
26 skin disease 10.3
27 panophthalmitis 10.2 CD4 B4GALNT2
28 allergic hypersensitivity disease 10.2
29 tinea imbricata 10.2
30 dermatitis 10.2
31 tinea favosa 10.2
32 alopecia 10.2
33 otitis externa 10.2 POLR2B CBSL B4GALNT2
34 external ear disease 10.2 POLR2B CBSL B4GALNT2
35 hypopyon 10.2 CD4 B4GALNT2
36 erythrasma 10.2
37 esophageal candidiasis 10.2 CYP51A1 CD4
38 conidiobolomycosis 10.1 CYP51A1 CBSL B4GALNT2
39 aspergillosis 10.1
40 paronychia 10.1
41 corneal ulcer 10.1 CLEC7A B4GALNT2
42 noonan syndrome 4 10.1 POLR2B CD4
43 blastomycosis 10.1 CLEC7A CD4
44 fungal meningitis 10.1 CYP51A1 CD4
45 chronic venous insufficiency 10.1
46 venous insufficiency 10.1
47 pyoderma 10.1
48 hyper ige recurrent infection syndrome 1 10.1 CLEC7A CD4
49 pneumocystosis 10.0 CLEC7A CD4
50 penicilliosis 10.0 POLR2B CLEC7A CD4

Comorbidity relations with Dermatomycosis via Phenotypic Disease Network (PDN): (show all 21)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Alzheimer Disease
Decubitus Ulcer Deficiency Anemia
Diabetic Polyneuropathy Esophagitis
Familial Atrial Fibrillation Generalized Atherosclerosis
Heart Disease Hypertension, Essential
Hypothyroidism Iron Deficiency Anemia
Mitral Valve Disease Osteoporosis
Paralytic Ileus Peripheral Vascular Disease
Protein-Energy Malnutrition Respiratory Failure
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Dermatomycosis:



Diseases related to Dermatomycosis

Symptoms & Phenotypes for Dermatomycosis

Drugs & Therapeutics for Dermatomycosis

Drugs for Dermatomycosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amorolfine Approved, Investigational Phase 4 78613-35-1
2
Ciclopirox Approved, Investigational Phase 4 29342-05-0 2749
3
Clotrimazole Approved, Vet_approved Phase 4 23593-75-1 2812
4
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
5 Cytochrome P-450 Enzyme Inhibitors Phase 4
6 Hormone Antagonists Phase 4
7 Hormones Phase 4
8 Cytochrome P-450 CYP3A Inhibitors Phase 4
9 Anti-Infective Agents, Local Phase 4
10 Dermatologic Agents Phase 4
11 Keratolytic Agents Phase 4
12 Antifungal Agents Phase 4
13 Anti-Infective Agents Phase 4
14
Sertaconazole Approved, Investigational Phase 3 99592-32-2 65863
15
Ketoconazole Approved, Investigational Phase 3 65277-42-1 47576
16
Nitric Oxide Approved Phase 2 10102-43-9 145068
17 Pharmaceutical Solutions Phase 2
18 Respiratory System Agents Phase 2
19 Antioxidants Phase 2
20 Endothelium-Dependent Relaxing Factors Phase 2
21 Anti-Asthmatic Agents Phase 2
22 Vasodilator Agents Phase 2
23 Bronchodilator Agents Phase 2
24 Neurotransmitter Agents Phase 2
25 Protective Agents Phase 2
26
Itraconazole Approved, Investigational Phase 1 84625-61-6 55283
27
Hydroxyitraconazole Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Multicentre, Randomized, Controlled Study of the Efficacy, Safety and Cost-effectiveness of a Sequential Therapy With RV4104A Ointment, Ciclopiroxolamine Cream and Ciclopirox Film-forming Solution Compared With Amorolfine Nail Lacquer Alone for the Treatment of Dermatophytic Onychomycosis (Toenail) Without Matrix Involvement Unknown status NCT01014637 Phase 4 Amorolfine (Antifungal);RV4104A, Ciclopiroxolamine, Cyclopirox (Keratolytic Agents/Antifungal)
2 Study for the Assessment of Safety and Efficacy of Ciclopirox Olamine Cream in 3 Months to 10 Years Old Children With Dermatomycoses Terminated NCT01646580 Phase 4 ciclopirox
3 Efficacy Of Sertaconazole 2% (ERTACZO) in the Treatment of Interdigital Tinea Pedis With Once a Day Treatment for 4 Weeks Unknown status NCT00856596 Phase 3 Sertaconazole nitrate cream 2%
4 Phase 3, Multicenter, Double-blind, Randomized, Non-inferiority Clinical Trial of Dapaconazole Cream 2% (Biolab Sanus Farmacêutica Ltda.) Versus Ketoconazole Cream 2% (Nizoral®, Janssen-Cilag Farmacêutica Ltda.) in Patients With Tinea Pedis Unknown status NCT03320486 Phase 3 Dapaconazole;Ketoconazole
5 A Blinded Placebo Controlled Clinical Trial To Evaluate Fungicidal Activity With The Topical Application Of Nitric Oxide Releasing Solution (Nors) In Subjects With Moderate To Severe Tinea Pedis (Athlete's Foot) Completed NCT02871011 Phase 2 Nitric Oxide;Water
6 The Efficacy of Pulsed Dye Laser in Dermatophytosis Completed NCT00351897 Phase 1
7 A Phase I Single-Center, Randomized, Open-label, Single Dose, Crossover Study in Korean Healthy Male Volunteers to Evaluate Pharmacokinetics of Lozanoc and Sporanox Completed NCT02493738 Phase 1 Lozanoc 50mg;Sporanox 100mg
8 Observational Study of the Efficacy, Safety and Tolerance of Travogen Cream (Isoconazole) and Travocort Cream (Isoconazole, Diflurcortolone) in the Treatment of Patients With Local Skin Mycosis of Various Etiology and Localization Completed NCT00722189

Search NIH Clinical Center for Dermatomycosis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Povidone

Cochrane evidence based reviews: dermatomycoses

Genetic Tests for Dermatomycosis

Anatomical Context for Dermatomycosis

MalaCards organs/tissues related to Dermatomycosis:

40
Skin, Testes, T Cells, Thymus, Kidney, Liver

Publications for Dermatomycosis

Articles related to Dermatomycosis:

(show top 50) (show all 1215)
# Title Authors PMID Year
1
Endemic Chromoblastomycosis Caused Predominantly by Fonsecaea nubica, Madagascar1. 61
32441639 2020
2
Unusual dermatomycoses caused by Nannizzia nana: the geophilic origin of human infections. 61
32232786 2020
3
Ex vivo nail infection as an effective preclinical method for screening of new topical antifungals. 61
32111505 2020
4
Subcutaneous pseudocystic phaeohyphomycosis due to Exophiala jeanselmei mimicking an epidermal cyst. 61
32374461 2020
5
8-Hydroxyquinoline-5-sulfonamides are promising antifungal candidates for the topical treatment of dermatomycosis. 61
31816165 2020
6
Deep fungal infections diagnosed by histology in Uganda: a 70-year retrospective study. 61
32242631 2020
7
Interdigital Tinea Nigra. 61
32391228 2020
8
Spotting sporotrichosis skin infection: The first Australian paediatric case series. 61
31613031 2020
9
Discovery of a novel and selective fungicide that targets fungal cell wall to treat dermatomycoses: 1,3-bis(3,4-dichlorophenoxy)propan-2-aminium chloride. 61
31657052 2020
10
Effectiveness of an encecalin standardized extract of Ageratina pichinchensis on the treatment of onychomycosis in patients with diabetes mellitus. 61
32086985 2020
11
The potential for use of non-thermal plasma in microbiology and medicine. 61
32326713 2020
12
Auxotrophic mutations of Trichophyton rubrum created by in vitro synthesized Cas9 ribonucleoprotein. 61
31959181 2020
13
Prognostic factors influencing the treatment outcome of onychomycosis Candida. 61
31603597 2020
14
Dermatomycoses in the Israeli defense forces-Epidemiological and clinical aspects. 61
31599024 2020
15
Epidemiological and clinical aspects of patients with Neoscytalidium spp. dermatomycoses in Switzerland. 61
31374133 2020
16
Identification of Dermatophyte and Nondermatophyte Molds Isolated from Animal Lesions Suspected to Dermatomycoses. 61
32055538 2020
17
Dermatomycosis in Cutaneous Tumors is a Predictor for Non-malignancy: A Cross-sectional Study. 61
31969235 2019
18
Epidemiology of dermatomycoses in southwest Poland, years 2011-2016. 61
31839778 2019
19
Sporotrichosis in the Highlands of Madagascar, 2013-20171. 61
31538565 2019
20
An unusual case of Lyme borreliosis: Can we miss it? 61
31579469 2019
21
ITS rDNA Gene Analysis Versus MALDI-TOF MS For Identification of Neoscytalidium dimidiatum Isolated from Onychomycosis and Dermatomycosis Cases in Medellin (Colombia). 61
31480602 2019
22
[Dermatophytosis caused by rare anthropophilic and zoophilic agents]. 61
31139861 2019
23
[Do the new molecular assays-microarray and realtime polymerase chain reaction-for dermatophyte detection keep what they promise?] 61
31263912 2019
24
Epidemiological survey of onychomycosis pathogens in Japan by real-time PCR. 61
30380094 2019
25
Occurrence of dermatophytoses in patients from the Sistema Único de Saúde. 61
31365657 2019
26
Comparing real-time PCR and Calcofluor-white with conventional methods for rapid detection of dermatophytes: Across-sectional study. 61
31022417 2019
27
Rapid tools to gain insights into the interaction dynamics of new 8-hydroxyquinolines with few fungal lines. 61
30450782 2019
28
Antifungal Activity of Griseofulvin Derivatives against Phytopathogenic Fungi in Vitro and in Vivo and Three-Dimensional Quantitative Structure-Activity Relationship Analysis. 61
31083998 2019
29
Tinea corporis infection manifestating as retinochoroiditis-an unusual presentation. 61
31131426 2019
30
Multiple abscesses in the lower extremities caused by Trichophyton rubrum. 61
30894136 2019
31
2016 Epidemiological Survey of Dermatomycoses in Japan. 61
31474694 2019
32
[Trichophyton mentagrophytes-from snow leopard to man : A molecular approach for uncovering the chain of infection]. 61
30120492 2018
33
A comparison of conventional rapid methods in diagnosis of superficial and cutaneous mycoses based on KOH, Chicago sky blue 6B and calcofluor white stains. 61
30873272 2018
34
The Oomycete Pythium oligandrum Can Suppress and Kill the Causative Agents of Dermatophytoses. 61
29967972 2018
35
[Tinea capitis and onychomycosis due to Trichophyton soudanense : Successful treatment with fluconazole-literature review]. 61
29589043 2018
36
[Hedgehog fungi in a dermatological office in Munich : Case reports and review]. 61
29435597 2018
37
Characterization of Nannizziopsis guarroi with genomic and proteomic analysis in three lizard species. 61
29420823 2018
38
[Prevalence of dermatomycoses in professional football players : A study based on data of German Bundesliga fitness check-ups (2013-2015) compared to data of the general population]. 61
29417157 2018
39
Distal Lateral Subungual Onychomycosis Owing to Tritirachium oryzae: A Bystander or Invader? 61
29164433 2018
40
Dermatomycoses Due to Nannizzia praecox (Formerly Microsporum praecox) in Germany: Case Reports and Review of the Literature. 61
29067631 2018
41
Combined analysis of gene expression and genome binding profiles identified potential therapeutic targets of ciclopirox in Ewing sarcoma. 61
29328472 2018
42
[Dermatophytosis due to Trichophyton violaceum at the parasitology-mycology laboratory of the military hospital of Meknes (about twelve cases)]. 61
29433854 2018
43
Generic selection criteria for safety and patient benefit [VII]: Comparing the physicochemical and pharmaceutical properties of brand-name and generic terbinafine hydrochloride cream. 61
29479048 2018
44
Molecular epidemiology of Trichophyton quinckeanum - a zoophilic dermatophyte on the rise. 61
29314679 2018
45
Criteria for the selection of switch OTC drugs based on patient benefits, efficacy, and safety [II]: Comparing the physicochemical and pharmaceutical properties of brand-name and switch OTC terbinafine hydrochloride cream. 61
30224597 2018
46
Cutaneous lesions due to Trichosporon jirovecii in a tortoise (Testudo hermanni). 61
28794959 2017
47
Human Infections with Microsporum gypseum Complex (Nannizzia gypsea) in Slovenia. 61
28840426 2017
48
[Fungal aetiologies and contributing factors of interdigital tinea pedis among policemen in Abidjan (Ivory Coast)]. 61
28887005 2017
49
Caffeic acid and licochalcone A interfere with the glyoxylate cycle of Trichophyton rubrum. 61
29174577 2017
50
[Pulmonary Embolism Despite Rivaroxaban in an Obese Patient]. 61
29017215 2017

Variations for Dermatomycosis

Expression for Dermatomycosis

Search GEO for disease gene expression data for Dermatomycosis.

Pathways for Dermatomycosis

GO Terms for Dermatomycosis

Biological processes related to Dermatomycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of interleukin-2 biosynthetic process GO:0045086 8.62 CLEC7A CD4

Molecular functions related to Dermatomycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 coreceptor activity GO:0015026 8.62 RGMB CD4

Sources for Dermatomycosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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