Aliases & Classifications for Dermatosis Papulosa Nigra

MalaCards integrated aliases for Dermatosis Papulosa Nigra:

Name: Dermatosis Papulosa Nigra 57 12 44 15 17 71

Characteristics:

OMIM®:

57 (Updated 05-Mar-2021)
Inheritance:
? autosomal dominant


HPO:

31
dermatosis papulosa nigra:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:4400
OMIM® 57 125600
MeSH 44 C562379
NCIt 50 C2984
SNOMED-CT 67 254669003
ICD10 32 L82
MedGen 41 C0011645
SNOMED-CT via HPO 68 199879009 263681008 95320005
UMLS 71 C0011645

Summaries for Dermatosis Papulosa Nigra

MalaCards based summary : Dermatosis Papulosa Nigra is related to keratosis and keratosis, seborrheic. An important gene associated with Dermatosis Papulosa Nigra is FGFR3 (Fibroblast Growth Factor Receptor 3), and among its related pathways/superpathways is Central carbon metabolism in cancer. The drugs Pharmaceutical Solutions and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include skin, and related phenotype is abnormality of the skin.

Wikipedia : 74 Dermatosis papulosa nigra (DPN) is a condition of many small, benign skin lesions on the face, a... more...

More information from OMIM: 125600

Related Diseases for Dermatosis Papulosa Nigra

Graphical network of the top 20 diseases related to Dermatosis Papulosa Nigra:



Diseases related to Dermatosis Papulosa Nigra

Symptoms & Phenotypes for Dermatosis Papulosa Nigra

Human phenotypes related to Dermatosis Papulosa Nigra:

31
# Description HPO Frequency HPO Source Accession
1 abnormality of the skin 31 HP:0000951

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Mar-2021)
Skin:
black to dark-brown cupoliform or flat facial papules
? variant of seborrheic keratoses

Misc:
occurrence predominantly in blacks

Clinical features from OMIM®:

125600 (Updated 05-Mar-2021)

Drugs & Therapeutics for Dermatosis Papulosa Nigra

Drugs for Dermatosis Papulosa Nigra (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions Phase 2
2
Racepinephrine Approved 329-65-7 838
3
Lidocaine Approved, Vet_approved 137-58-6 3676
4
Epinephrine Approved, Vet_approved 51-43-4 5816
5 Anesthetics
6 Epinephryl borate

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 2 Open Label Study of A-101 Topical Solution in Subjects With Dermatosis Papulosa Nigra Completed NCT03224598 Phase 2 A-101 Topical Solution 40%
2 Efficacy of a 585 nm Pulsed Dye Laser (PDL) for the Treatment of Dermatosis Papulosa Nigra, and Compare it to Therapy With Curettage and Electrodesiccation. Completed NCT00710203

Search NIH Clinical Center for Dermatosis Papulosa Nigra

Cochrane evidence based reviews: dermatosis papulosa nigra

Genetic Tests for Dermatosis Papulosa Nigra

Anatomical Context for Dermatosis Papulosa Nigra

MalaCards organs/tissues related to Dermatosis Papulosa Nigra:

40
Skin

Publications for Dermatosis Papulosa Nigra

Articles related to Dermatosis Papulosa Nigra:

(show top 50) (show all 56)
# Title Authors PMID Year
1
Elective Treatment of Dermatosis Papulosa Nigra: A Review of Treatment Modalities. 61
33017107 2020
2
Superimposed segmental dermatosis papulosa nigra. 61
31642076 2020
3
Dermatosis Papulosa Nigra: A Quality of Life Survey Study. 61
32308781 2020
4
Treatment of dermatosis papulosa nigra using a carbon dioxide laser. 61
31990432 2020
5
[Clinical-pathological analysis of 71 cases of dermatosis papulosa nigra of Han Chinese people]. 61
31607018 2019
6
Pigmented transverse nasal band: A distinct presentation. 61
29808609 2019
7
Recent advances in managing and understanding seborrheic keratosis. 61
31508199 2019
8
First case of dermatosis papulosa nigra in a white child. 61
28846142 2017
9
A clinical, dermoscopic, and histopathological study of Dermatosis Papulosa Nigra (DPN) - An Indian perspective. 61
28485013 2017
10
Dermatosis papulosa nigra: a clinically and histopathologically distinct entity. 61
28916031 2017
11
Cutaneous problems in elderly diabetics: A population-based comparative cross-sectional survey. 61
27647359 2017
12
A Clinicopathological and Dermoscopic Correlation of Seborrheic Keratosis. 61
27904179 2016
13
Early-onset dermatosis papulosa nigra. 61
26639606 2016
14
Carbon dioxide laser ablation of dermatosis papulosa nigra: high satisfaction and few complications in patients with pigmented skin. 61
26868030 2016
15
Effectiveness of the Pulse Dye Laser Treatment in a Caucasian Women With Dermatosis Papulosa Nigra. 61
26120179 2015
16
Dermatosis Papulosa Nigra and 10,600-nm CO2 laser, a good choice. 61
24131098 2014
17
What's new in objective assessment and treatment of facial hyperpigmentation? 61
24679999 2014
18
Acquired hyperpigmentations. 61
24626644 2014
19
Dermatologic conditions in skin of color: part II. Disorders occurring predominately in skin of color. 61
23939568 2013
20
Spectrum of seborrheic keratoses in South Indians: a clinical and dermoscopic study. 61
21727696 2011
21
Laser eradication of pigmented lesions: a review. 61
21492309 2011
22
Postprocedural wound-healing efficacy following removal of dermatosis papulosa nigra lesions in an African American population: a comparison of a skin protectant ointment and a topical antibiotic. 61
21247663 2011
23
Treatment of dermatosis papulosa nigra in 10 patients: a comparison trial of electrodesiccation, pulsed dye laser, and curettage. 61
21040130 2010
24
Clinical features and treatment of dermatosis papulosa nigra in migrants to Italy. 61
21137605 2010
25
FGFR3 and PIK3CA mutations in stucco keratosis and dermatosis papulosa nigra. 61
19845664 2010
26
Dermatosis papulosa nigra treatment with fractional photothermolysis. 61
19796255 2009
27
Comparison of electrodesiccation and potassium-titanyl-phosphate laser for treatment of dermatosis papulosa nigra. 61
19469798 2009
28
Are all seborrheic keratoses benign? Review of the typical lesion and its variants. 61
18845088 2008
29
Treatment of dermatosis papulosa nigra with a 1064 nm Nd:YAG laser: report of two cases. 61
18569266 2008
30
Dermatosis papulosa nigra in Dakar, Senegal. 61
17919208 2007
31
Eruptive dermatosis papulosa nigra as a possible sign of internal malignancy. 61
17269973 2007
32
A randomized, double-blind comparison of two topical anesthetic formulations prior to electrodesiccation of dermatosis papulosa nigra. 61
16393591 2006
33
Study of the skin disease spectrum occurring in an Afro-Caribbean population. 61
12694494 2003
34
[Characteristics of genetically pigmented skins]. 61
15015846 2003
35
Dermatosis papulosa nigra in a young child. 61
8302739 1993
36
[Dermatosis papulosa nigra]. 61
3622869 1987
37
[A case of dermatosis papulosa nigra in a white man]. 61
6240957 1984
38
[Verrucous-form dermatosis papulosa nigra of the eyelid]. 61
6501785 1984
39
A surgical approach for dermatosis papulosa nigra. 61
6229500 1983
40
Dermatosis papulosa nigra. 61
6226495 1983
41
Dermatosis papulosa nigra and seborrheic keratoses: clinical aspects. 61
7386792 1980
42
[Dermatosis papulosa nigra]. 61
4802175 1973
43
[Castellani's dermatosis papulosa nigra]. 61
5558861 1971
44
Dermatosis papulosa nigra. 61
5662294 1968
45
[Dermatosis papulosa nigra]. 61
6045812 1967
46
[Dermatosis papulosa nigra (Castellani 1925)]. 61
4223695 1966
47
DERMATOSIS PAPULOSA NIGRA. 61
14122095 1964
48
[DERMATOSIS PAPULOSA NIGRA (CASTELLANI 1925)]. 61
14143405 1964
49
[CASTELLANI'S DERMATOSIS PAPULOSA NIGRA]. 61
14165081 1964
50
[CASTELLANI'S DERMATOSIS PAPULOSA NIGRA; CLINICAL AND GEOGRAPHIC NOTE]. 61
14119317 1963

Variations for Dermatosis Papulosa Nigra

Expression for Dermatosis Papulosa Nigra

Search GEO for disease gene expression data for Dermatosis Papulosa Nigra.

Pathways for Dermatosis Papulosa Nigra

Pathways related to Dermatosis Papulosa Nigra according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.47 PIK3CA FGFR3

GO Terms for Dermatosis Papulosa Nigra

Biological processes related to Dermatosis Papulosa Nigra according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of melanin biosynthetic process GO:0048022 8.62 OPN3 MFSD12

Sources for Dermatosis Papulosa Nigra

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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