Aliases & Classifications for Dermatosis Papulosa Nigra

MalaCards integrated aliases for Dermatosis Papulosa Nigra:

Name: Dermatosis Papulosa Nigra 57 12 44 15 73

Characteristics:

OMIM:

57
Inheritance:
? autosomal dominant


Classifications:



External Ids:

OMIM 57 125600
Disease Ontology 12 DOID:4400
ICD10 33 L82
MeSH 44 C562379
NCIt 50 C2984
MedGen 42 C0011645
SNOMED-CT via HPO 69 199879009 95320005
UMLS 73 C0011645

Summaries for Dermatosis Papulosa Nigra

MalaCards based summary : Dermatosis Papulosa Nigra is related to keratosis and pancreatic neuroendocrine tumor. An important gene associated with Dermatosis Papulosa Nigra is FGFR3 (Fibroblast Growth Factor Receptor 3), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and PI3K/AKT activation. The drugs Pharmaceutical Solutions and Epinephrine have been mentioned in the context of this disorder. Affiliated tissues include skin, and related phenotypes are abnormality of the skin and Decreased viability

Wikipedia : 76 Dermatosis papulosa nigra (DPN) is a condition of many small, benign skin lesions on the face, a... more...

Description from OMIM: 125600

Related Diseases for Dermatosis Papulosa Nigra

Graphical network of the top 20 diseases related to Dermatosis Papulosa Nigra:



Diseases related to Dermatosis Papulosa Nigra

Symptoms & Phenotypes for Dermatosis Papulosa Nigra

Symptoms via clinical synopsis from OMIM:

57
Skin:
black to dark-brown cupoliform or flat facial papules
? variant of seborrheic keratoses

Misc:
occurrence predominantly in blacks


Clinical features from OMIM:

125600

Human phenotypes related to Dermatosis Papulosa Nigra:

32
# Description HPO Frequency HPO Source Accession
1 abnormality of the skin 32 HP:0000951

GenomeRNAi Phenotypes related to Dermatosis Papulosa Nigra according to GeneCards Suite gene sharing:

26 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.74 PIK3CA MTOR
2 Decreased viability GR00221-A-1 9.74 PIK3CA FGFR3 MTOR
3 Decreased viability GR00221-A-2 9.74 PIK3CA FGFR3
4 Decreased viability GR00221-A-3 9.74 FGFR3
5 Decreased viability GR00221-A-4 9.74 PIK3CA MTOR
6 Decreased viability GR00342-S-1 9.74 MTOR
7 Decreased viability GR00342-S-2 9.74 MTOR
8 Decreased viability GR00402-S-2 9.74 PIK3CA FGFR3 MTOR
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-10 9.61 FGFR3
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.61 MTOR
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.61 PIK3CA
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.61 MTOR PIK3CA
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 9.61 FGFR3
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.61 PIK3CA FGFR3 MTOR
15 Decreased cell migration GR00055-A-1 9.33 FGFR3 MTOR PIK3CA

MGI Mouse Phenotypes related to Dermatosis Papulosa Nigra:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 no phenotypic analysis MP:0003012 8.8 FGFR3 MTOR PIK3CA

Drugs & Therapeutics for Dermatosis Papulosa Nigra

Drugs for Dermatosis Papulosa Nigra (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions Phase 2
2
Epinephrine Approved, Vet_approved Not Applicable 51-43-4 5816
3
Lidocaine Approved, Vet_approved Not Applicable 137-58-6 3676
4
Racepinephrine Approved Not Applicable 329-65-7 838
5 Anesthetics Not Applicable
6 Epinephryl borate Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Study of A-101 Topical Solution in Subjects With Dermatosis Papulosa Nigra Active, not recruiting NCT03224598 Phase 2 A-101 Topical Solution 40%
2 Dermatosis Papulosa Nigra Completed NCT00710203 Not Applicable

Search NIH Clinical Center for Dermatosis Papulosa Nigra

Cochrane evidence based reviews: dermatosis papulosa nigra

Genetic Tests for Dermatosis Papulosa Nigra

Anatomical Context for Dermatosis Papulosa Nigra

MalaCards organs/tissues related to Dermatosis Papulosa Nigra:

41
Skin

Publications for Dermatosis Papulosa Nigra

Articles related to Dermatosis Papulosa Nigra:

(show all 24)
# Title Authors Year
1
First case of dermatosis papulosa nigra in a white child. ( 28846142 )
2017
2
Dermatosis papulosa nigra: a clinically and histopathologically distinct entity. ( 28916031 )
2017
3
A clinical, dermoscopic, and histopathological study of Dermatosis Papulosa Nigra (DPN) - An Indian perspective. ( 28485013 )
2017
4
Early-onset dermatosis papulosa nigra. ( 26639606 )
2016
5
Carbon dioxide laser ablation of dermatosis papulosa nigra: high satisfaction and few complications in patients with pigmented skin. ( 26868030 )
2016
6
Effectiveness of the Pulse Dye Laser Treatment in a Caucasian Women With Dermatosis Papulosa Nigra. ( 26120179 )
2015
7
Dermatosis Papulosa Nigra and 10,600-nm CO2 laser, a good choice. ( 24131098 )
2013
8
Postprocedural wound-healing efficacy following removal of dermatosis papulosa nigra lesions in an African American population: a comparison of a skin protectant ointment and a topical antibiotic. ( 21247663 )
2011
9
FGFR3 and PIK3CA mutations in stucco keratosis and dermatosis papulosa nigra. ( 19845664 )
2010
10
Clinical features and treatment of dermatosis papulosa nigra in migrants to Italy. ( 21137605 )
2010
11
Treatment of dermatosis papulosa nigra in 10 patients: a comparison trial of electrodesiccation, pulsed dye laser, and curettage. ( 21040130 )
2010
12
Comparison of electrodesiccation and potassium-titanyl-phosphate laser for treatment of dermatosis papulosa nigra. ( 19469798 )
2009
13
Dermatosis papulosa nigra treatment with fractional photothermolysis. ( 19796255 )
2009
14
Treatment of dermatosis papulosa nigra with a 1064 nm Nd:YAG laser: report of two cases. ( 18569266 )
2008
15
Dermatosis papulosa nigra in Dakar, Senegal. ( 17919208 )
2007
16
Eruptive dermatosis papulosa nigra as a possible sign of internal malignancy. ( 17269973 )
2007
17
A randomized, double-blind comparison of two topical anesthetic formulations prior to electrodesiccation of dermatosis papulosa nigra. ( 16393591 )
2006
18
Dermatosis papulosa nigra in a young child. ( 8302739 )
1993
19
Dermatosis papulosa nigra. ( 6226495 )
1983
20
A surgical approach for dermatosis papulosa nigra. ( 6229500 )
1983
21
Dermatosis papulosa nigra and seborrheic keratoses: clinical aspects. ( 7386792 )
1980
22
Dermatosis papulosa nigra. ( 5662294 )
1968
23
DERMATOSIS PAPULOSA NIGRA. ( 14122095 )
1964
24
A case for diagnosis [dermatosis papulosa nigra?]. ( 18101154 )
1948

Variations for Dermatosis Papulosa Nigra

Expression for Dermatosis Papulosa Nigra

Search GEO for disease gene expression data for Dermatosis Papulosa Nigra.

Pathways for Dermatosis Papulosa Nigra

Pathways related to Dermatosis Papulosa Nigra according to GeneCards Suite gene sharing:

(show all 45)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.05 FGFR3 MTOR PIK3CA
2
Show member pathways
12.71 FGFR3 MTOR PIK3CA
3
Show member pathways
12.56 FGFR3 MTOR PIK3CA
4
Show member pathways
12.45 FGFR3 MTOR PIK3CA
5 12.41 FGFR3 MTOR PIK3CA
6
Show member pathways
12.34 FGFR3 MTOR PIK3CA
7
Show member pathways
12.27 FGFR3 MTOR PIK3CA
8
Show member pathways
12.04 MTOR PIK3CA
9
Show member pathways
12.02 MTOR PIK3CA
10 12.02 FGFR3 MTOR PIK3CA
11 11.99 MTOR PIK3CA
12
Show member pathways
11.97 FGFR3 PIK3CA
13
Show member pathways
11.96 MTOR PIK3CA
14
Show member pathways
11.96 FGFR3 MTOR PIK3CA
15
Show member pathways
11.92 MTOR PIK3CA
16
Show member pathways
11.88 MTOR PIK3CA
17 11.88 MTOR PIK3CA
18
Show member pathways
11.87 MTOR PIK3CA
19
Show member pathways
11.86 FGFR3 PIK3CA
20
Show member pathways
11.85 FGFR3 MTOR PIK3CA
21
Show member pathways
11.84 MTOR PIK3CA
22
Show member pathways
11.83 MTOR PIK3CA
23
Show member pathways
11.82 MTOR PIK3CA
24 11.79 FGFR3 PIK3CA
25
Show member pathways
11.78 FGFR3 MTOR
26 11.75 MTOR PIK3CA
27
Show member pathways
11.74 MTOR PIK3CA
28
Show member pathways
11.73 FGFR3 MTOR PIK3CA
29 11.7 MTOR PIK3CA
30
Show member pathways
11.67 MTOR PIK3CA
31 11.63 MTOR PIK3CA
32 11.62 MTOR PIK3CA
33 11.6 MTOR PIK3CA
34
Show member pathways
11.59 MTOR PIK3CA
35
Show member pathways
11.59 FGFR3 MTOR PIK3CA
36 11.47 MTOR PIK3CA
37 11.45 MTOR PIK3CA
38 11.41 MTOR PIK3CA
39
Show member pathways
11.39 MTOR PIK3CA
40 11.35 MTOR PIK3CA
41 11.29 FGFR3 MTOR PIK3CA
42 11.2 MTOR PIK3CA
43 11.01 MTOR PIK3CA
44 10.91 MTOR PIK3CA
45 10.61 FGFR3 MTOR PIK3CA

GO Terms for Dermatosis Papulosa Nigra

Cellular components related to Dermatosis Papulosa Nigra according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol 3-kinase complex GO:0005942 8.62 MTOR PIK3CA

Biological processes related to Dermatosis Papulosa Nigra according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphorylation GO:0016310 9.58 FGFR3 MTOR PIK3CA
2 protein phosphorylation GO:0006468 9.54 FGFR3 MTOR PIK3CA
3 protein autophosphorylation GO:0046777 9.46 FGFR3 MTOR
4 phosphatidylinositol phosphorylation GO:0046854 9.43 FGFR3 PIK3CA
5 phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 9.32 FGFR3 PIK3CA
6 cardiac muscle contraction GO:0060048 9.26 MTOR PIK3CA
7 negative regulation of macroautophagy GO:0016242 9.16 MTOR PIK3CA
8 anoikis GO:0043276 8.96 MTOR PIK3CA
9 positive regulation of protein kinase B signaling GO:0051897 8.8 FGFR3 MTOR PIK3CA

Molecular functions related to Dermatosis Papulosa Nigra according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATP binding GO:0005524 9.43 FGFR3 MTOR PIK3CA
2 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.16 FGFR3 PIK3CA
3 kinase activity GO:0016301 9.13 FGFR3 MTOR PIK3CA
4 1-phosphatidylinositol-3-kinase activity GO:0016303 8.62 FGFR3 PIK3CA

Sources for Dermatosis Papulosa Nigra

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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