MCID: DRM012
MIFTS: 25

Dermis Tumor

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Dermis Tumor

MalaCards integrated aliases for Dermis Tumor:

Name: Dermis Tumor 12 15
Neoplasm of Dermis 12
Tumour of Dermis 12
Tumor of Dermis 12
Dermis Tumour 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2438
NCIt 50 C4475
SNOMED-CT 67 254735005
UMLS 70 C0346041

Summaries for Dermis Tumor

MalaCards based summary : Dermis Tumor, also known as neoplasm of dermis, is related to malignant dermis tumor and colon leiomyoma. An important gene associated with Dermis Tumor is FH (Fumarate Hydratase), and among its related pathways/superpathways are Pathways in cancer and Carbon metabolism. Affiliated tissues include kidney, smooth muscle and colon.

Related Diseases for Dermis Tumor

Diseases in the Dermis Tumor family:

Malignant Dermis Tumor

Diseases related to Dermis Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 malignant dermis tumor 11.2
2 colon leiomyoma 10.2 MED12 FH
3 kidney angiomyolipoma 10.2 FNIP1 FLCN
4 gastric leiomyoma 10.2 FH CALD1
5 diffuse peritoneal leiomyomatosis 10.2 MED12 CALD1
6 peritoneal benign neoplasm 10.2 MED12 CALD1
7 pneumothorax, primary spontaneous 10.2 FNIP1 FLCN
8 intravenous leiomyomatosis 10.2 MED12 CALD1
9 cutaneous leiomyosarcoma 10.2 FH CALD1
10 skin tag 10.2 FNIP1 FLCN
11 cellular leiomyoma 10.2 MED12 CALD1
12 atypical polypoid adenomyoma 10.2 MED12 CALD1
13 adenomyoma 10.2 MED12 CALD1
14 angiolipoma 10.2 FLCN CALD1
15 oncocytoma 10.1 FNIP2 FLCN FH
16 kidney benign neoplasm 10.1 FNIP1 FLCN
17 familial renal oncocytoma 10.1 FNIP2 FNIP1 FLCN
18 multilocular clear cell renal cell carcinoma 10.1 FNIP2 FNIP1 FLCN
19 cardiomyopathy, dilated, 1gg 10.1 SDHA FH
20 bladder sarcoma 10.1 MED12 CALD1
21 myoma 10.1 MED12 FH CALD1
22 bizarre leiomyoma 10.1 MED12 FH CALD1
23 uterine benign neoplasm 10.1 MED12 FH CALD1
24 reproductive organ benign neoplasm 10.1 MED12 FH CALD1
25 fumarase deficiency 10.0 SDHA FH
26 smooth muscle tumor 10.0 MED12 CALD1
27 birt-hogg-dube syndrome 10.0 FNIP2 FNIP1 FLCN FH
28 neural crest tumor 10.0 SDHD SDHA
29 foster-kennedy syndrome 10.0 SDHD SDHA
30 gastric leiomyosarcoma 10.0 SDHD SDHA
31 paragangliomas 1 9.9 SDHD SDHA
32 cerebellar angioblastoma 9.9 SDHD SDHA
33 extra-adrenal pheochromocytoma 9.9 SDHD SDHA
34 pheochromocytoma-paraganglioma 9.9 SDHD SDHA
35 esophagus leiomyoma 9.9 SDHD SDHA
36 carney triad 9.9 SDHD SDHA
37 retinal hemangioblastoma 9.9 ELOC ELOB CUL2
38 erythrocytosis, familial, 2 9.9 ELOC ELOB CUL2
39 leiomyoma 9.9 MED12 FH COL4A6
40 adrenal medulla cancer 9.9 SDHD SDHA
41 chondroma 9.9 SDHD SDHA
42 persistent generalized lymphadenopathy 9.8 SDHD SDHA FH
43 glomus tumor 9.8 SDHD CALD1
44 paraganglioma and gastric stromal sarcoma 9.8 SDHD SDHA FH
45 paraganglioma 9.8 SDHD SDHA FH
46 hereditary paraganglioma-pheochromocytoma syndromes 9.8 SDHD SDHA FH
47 endocrine organ benign neoplasm 9.8 SDHD SDHA FH
48 renal cell carcinoma, papillary, 1 9.8 FNIP2 FNIP1 FLCN FH ELOC
49 mitochondrial complex ii deficiency, nuclear type 1 9.7 SDHD SDHA
50 leiomyomatosis 9.7 MED12 FLCN FH COL4A6

Graphical network of the top 20 diseases related to Dermis Tumor:



Diseases related to Dermis Tumor

Symptoms & Phenotypes for Dermis Tumor

Drugs & Therapeutics for Dermis Tumor

Search Clinical Trials , NIH Clinical Center for Dermis Tumor

Genetic Tests for Dermis Tumor

Anatomical Context for Dermis Tumor

MalaCards organs/tissues related to Dermis Tumor:

40
Kidney, Smooth Muscle, Colon, Skin

Publications for Dermis Tumor

Articles related to Dermis Tumor:

# Title Authors PMID Year
1
Dermatofibrosarcoma protuberans post basal cell carcinoma excision: A case report. 61
27494371 2016
2
Application of electron microscopic analysis and fluorescent in situ hybridization technique for the successful diagnosis of extraskeletal Ewing's sarcoma. 61
25959109 2015
3
A case of diffuse large B-cell lymphoma misdiagnosed as an erysipelas of the face. 61
24278087 2013
4
Suppression of an already established tumor growing through activated mucosal CTLs induced by oral administration of tumor antigen with cholera toxin. 61
18322209 2008

Variations for Dermis Tumor

Expression for Dermis Tumor

Search GEO for disease gene expression data for Dermis Tumor.

Pathways for Dermis Tumor

GO Terms for Dermis Tumor

Cellular components related to Dermis Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 elongin complex GO:0070449 9.26 ELOC ELOB
2 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 9.16 SDHD SDHA
3 Cul2-RING ubiquitin ligase complex GO:0031462 9.13 ELOC ELOB CUL2
4 VCB complex GO:0030891 8.8 ELOC ELOB CUL2

Biological processes related to Dermis Tumor according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 protein ubiquitination GO:0016567 9.8 MED12 ELOC ELOB CUL2
2 regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061418 9.54 ELOC ELOB CUL2
3 regulation of protein phosphorylation GO:0001932 9.5 FNIP2 FNIP1 FLCN
4 positive regulation of TOR signaling GO:0032008 9.48 FNIP1 FLCN
5 negative regulation of TOR signaling GO:0032007 9.46 FNIP1 FLCN
6 translational elongation GO:0006414 9.43 ELOC ELOB
7 TOR signaling GO:0031929 9.4 FNIP1 FLCN
8 negative regulation of mitochondrion organization GO:0010823 9.26 FNIP1 FLCN
9 mitochondrial electron transport, succinate to ubiquinone GO:0006121 9.16 SDHD SDHA
10 regulation of pro-B cell differentiation GO:2000973 8.96 FNIP1 FLCN
11 tricarboxylic acid cycle GO:0006099 8.8 SDHD SDHA FH

Molecular functions related to Dermis Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.07 WDR64 SDHD SDHA MED12 FNIP2 FNIP1
2 translation elongation factor activity GO:0003746 9.16 ELOC ELOB
3 ATPase inhibitor activity GO:0042030 8.96 FNIP2 FNIP1
4 succinate dehydrogenase activity GO:0000104 8.62 SDHD SDHA

Sources for Dermis Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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