MCID: DRM050
MIFTS: 28

Dermographism, Familial

Categories: Genetic diseases, Rare diseases, Skin diseases

Aliases & Classifications for Dermographism, Familial

MalaCards integrated aliases for Dermographism, Familial:

Name: Dermographism, Familial 57
Familial Dermographism 53 73
Dermo-Distortive Urticaria 53
Dermodistortive Urticaria 73
Dermatographism, Familial 57
Symptomatic Dermographism 73
Familial Dermatographism 53
Dermatographia 53
Dermographism 53

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
dermographism, familial:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 57 125635
MedGen 42 C1852145

Summaries for Dermographism, Familial

NIH Rare Diseases : 53 Familial dermographism is a condition also known as skin writing. When people who have dermatographia lightly scratch their skin, the scratches redden into a raised wheal similar to hives. Signs and symptoms of dermatographia include raised red lines, swelling, inflammation, hive-like welts and itching. Symptoms usually disappear within 30 minutes. The exact cause of this condition is unknown. Treatment may invovle use of antihistamines if symptoms do not go away on their own.

MalaCards based summary : Dermographism, Familial, also known as familial dermographism, is related to dermatographia and physical urticaria, and has symptoms including integumentary system signs and symptoms and darier's sign. An important gene associated with Dermographism, Familial is PRG2 (Proteoglycan 2, Pro Eosinophil Major Basic Protein). Affiliated tissues include skin, and related phenotypes are stroke and dermatographic urticaria

Wikipedia : 76 Dermatographic urticaria (also known as dermographism, dermatographism or "skin writing") is a skin... more...

Description from OMIM: 125635

Related Diseases for Dermographism, Familial

Diseases related to Dermographism, Familial via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 23)
# Related Disease Score Top Affiliating Genes
1 dermatographia 12.3
2 physical urticaria 11.5
3 urticaria 10.5
4 mastocytosis, cutaneous 10.2
5 allergic conjunctivitis 10.1
6 conjunctivitis 10.1
7 cold urticaria 10.1
8 alopecia universalis congenita 9.9
9 alopecia 9.9
10 latex allergy 9.9
11 dermatomyositis 9.9
12 adult-onset still's disease 9.9
13 dermatitis 9.9
14 contact dermatitis 9.9
15 allergic contact dermatitis 9.9
16 cellulitis 9.9
17 mastocytosis 9.9
18 wells syndrome 9.9
19 chronic actinic dermatitis 9.9
20 fixed drug eruption 9.9
21 atopic keratoconjunctivitis 9.8 IGHE PRG2
22 hypereosinophilic syndrome 9.8 IGHE PRG2
23 asthma 9.7 IGHE PRG2

Graphical network of the top 20 diseases related to Dermographism, Familial:



Diseases related to Dermographism, Familial

Symptoms & Phenotypes for Dermographism, Familial

Symptoms via clinical synopsis from OMIM:

57
Skin:
dermographism
localized urticarial wheal and flare from a single skin stroke or scratch


Clinical features from OMIM:

125635

Human phenotypes related to Dermographism, Familial:

32
# Description HPO Frequency HPO Source Accession
1 stroke 32 HP:0001297
2 dermatographic urticaria 32 HP:0011971

UMLS symptoms related to Dermographism, Familial:


integumentary system signs and symptoms, darier's sign

Drugs & Therapeutics for Dermographism, Familial

Search Clinical Trials , NIH Clinical Center for Dermographism, Familial

Genetic Tests for Dermographism, Familial

Anatomical Context for Dermographism, Familial

MalaCards organs/tissues related to Dermographism, Familial:

41
Skin

Publications for Dermographism, Familial

Articles related to Dermographism, Familial:

# Title Authors Year
1
Familial dermographism. ( 2063925 )
1991

Variations for Dermographism, Familial

Expression for Dermographism, Familial

Search GEO for disease gene expression data for Dermographism, Familial.

Pathways for Dermographism, Familial

GO Terms for Dermographism, Familial

Biological processes related to Dermographism, Familial according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 8.96 IGHE PRG2
2 defense response to bacterium GO:0042742 8.62 IGHE PRG2

Sources for Dermographism, Familial

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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