MCID: DSC005
MIFTS: 33

Descending Colon Cancer

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Descending Colon Cancer

MalaCards integrated aliases for Descending Colon Cancer:

Name: Descending Colon Cancer 12 15
Malignant Neoplasm of Descending Colon 70
Malignant Tumor of Descending Colon 12
Malignant Neoplasm of Left Colon 12
Ca Descending Colon 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12190
ICD9CM 34 153.2
SNOMED-CT 67 93771007
ICD10 32 C18.6
UMLS 70 C0153435

Summaries for Descending Colon Cancer

MalaCards based summary : Descending Colon Cancer, also known as malignant neoplasm of descending colon, is related to mucinous adenocarcinoma and appendix adenocarcinoma. An important gene associated with Descending Colon Cancer is CEACAM5 (CEA Cell Adhesion Molecule 5), and among its related pathways/superpathways are Cell surface interactions at the vascular wall and Long-term depression. The drug Cola has been mentioned in the context of this disorder. Affiliated tissues include colon, lung and liver.

Related Diseases for Descending Colon Cancer

Diseases related to Descending Colon Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 174)
# Related Disease Score Top Affiliating Genes
1 mucinous adenocarcinoma 30.0 KRAS CEACAM5 CDX2
2 appendix adenocarcinoma 29.7 KRAS HRAS CDX2
3 ascending colon cancer 29.2 KRAS HRAS CEACAM5 CDX2
4 ileus 10.3
5 intussusception 10.2
6 ureter adenocarcinoma 10.2 CEACAM5 CDX2
7 laryngeal mucoepidermoid carcinoma 10.2 CEACAM5 CDX2
8 mucinous adenofibroma 10.2 CEACAM5 CDX2
9 pancreatic foamy gland adenocarcinoma 10.2 CEACAM5 CDX2
10 thymus adenocarcinoma 10.2 CEACAM5 CDX2
11 anal paget's disease 10.2 CEACAM5 CDX2
12 urinary bladder villous adenoma 10.2 CEACAM5 CDX2
13 vulva adenocarcinoma 10.2 CEACAM5 CDX2
14 vaginal tubulovillous adenoma 10.2 CEACAM5 CDX2
15 female urethral cancer 10.2 CEACAM5 CDX2
16 mucinous ovarian cystadenoma 10.2 CEACAM5 CDX2
17 mature teratoma 10.2 KRAS CEACAM5
18 krukenberg carcinoma 10.2 CEACAM5 CDX2
19 anal canal adenocarcinoma 10.2 CEACAM5 CDX2
20 gastric diffuse adenocarcinoma 10.2 CEACAM5 CDX2
21 linitis plastica 10.2 CEACAM5 CDX2
22 esophageal adenosquamous carcinoma 10.2 CEACAM5 CDX2
23 pancreatic cystadenocarcinoma 10.2 KRAS CEACAM5
24 colon neuroendocrine neoplasm 10.2 CEACAM5 CDX2
25 clear cell basal cell carcinoma 10.2 CEACAM5 CDX2
26 urachal adenocarcinoma 10.2 KRAS CEACAM5
27 nasal cavity olfactory neuroblastoma 10.2 CEACAM5 CDX2
28 pancreatic serous cystadenoma 10.1 CELA3B CEACAM5
29 rectosigmoid junction neoplasm 10.1 KRAS CEACAM5
30 ovarian mucinous adenocarcinoma 10.1 CEACAM5 CDX2
31 bile acid synthesis defect, congenital, 5 10.1 KRAS CEACAM5
32 endocervical carcinoma 10.1 CEACAM5 CDX2
33 common bile duct disease 10.1 CELA3B CEACAM5
34 constipation 10.1
35 microinvasive gastric cancer 10.1 CEACAM5 CDX2
36 tubular adenocarcinoma 10.1 CEACAM5 CDX2
37 endocervical adenocarcinoma 10.1 CEACAM5 CDX2
38 benign teratoma 10.1 CEACAM5 CDX2
39 cystic teratoma 10.0 KRAS CDX2
40 gastrointestinal carcinoma 10.0 CEACAM5 CDX2
41 intestinal obstruction 10.0 CEACAM5 CDX2
42 papillary adenocarcinoma 10.0 KRAS CEACAM5
43 aortic aneurysm, familial abdominal, 1 10.0
44 colorectal cancer 10.0
45 systemic lupus erythematosus 10.0
46 leukemia, chronic myeloid 10.0
47 gastric cancer 10.0
48 proteinuria, chronic benign 10.0
49 colitis 10.0
50 polymyositis 10.0

Comorbidity relations with Descending Colon Cancer via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Colorectal Cancer
Deficiency Anemia Intestinal Obstruction
Paralytic Ileus Rectosigmoid Junction Neoplasm

Graphical network of the top 20 diseases related to Descending Colon Cancer:



Diseases related to Descending Colon Cancer

Symptoms & Phenotypes for Descending Colon Cancer

Drugs & Therapeutics for Descending Colon Cancer

Drugs for Descending Colon Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Cola Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Controlled Trial to Evaluate Laparoscopic Versus Open Surgery in Transverse and Descending Colon Cancer Patients Unknown status NCT01861691 Phase 2

Search NIH Clinical Center for Descending Colon Cancer

Genetic Tests for Descending Colon Cancer

Anatomical Context for Descending Colon Cancer

MalaCards organs/tissues related to Descending Colon Cancer:

40
Colon, Lung, Liver, Myeloid, Lymph Node, Thyroid, Ovary

Publications for Descending Colon Cancer

Articles related to Descending Colon Cancer:

(show top 50) (show all 125)
# Title Authors PMID Year
1
Safety and effectiveness of high ligation of the inferior mesenteric artery for cancer of the descending colon under indocyanine green fluorescence imaging: a pilot study. 61
32297053 2021
2
Diaphragmatic plication for diaphragmatic eventration caused by chronic constipation: a case report. 61
33454855 2021
3
Genome sequence and annotation of Bacteroides sp aff. Thetaiotaomicron strain isolated from blood. 61
33771725 2021
4
[A Case of Anastomotic Recurrent Descending Colon Cancer Successfully Treated with Single-Incision Laparoscopic Partial Colectomy with Intracorporeal Anastomosis]. 61
33597370 2021
5
[A Case of Colon Cancer with Synchronous Multiple Metastases Successfully Treated with Combined Chemotherapy]. 61
33468739 2021
6
Inferior mesenteric arteriovenous fistula during treatment with bevacizumab in colorectal cancer patient: A case report. 61
33250967 2020
7
Neoplastic meningitis due to colorectal cancer. 61
32592151 2020
8
Which is more important in the management of splenic flexure colon cancer: strict central lymph node dissection or adequate bowel resection margin? 61
32548666 2020
9
Single-incision laparoscopic totally extraperitoneal repair for bilateral inguinal hernias after femoral-femoral artery bypass in a patient on antiplatelet therapy: A case report. 61
31430041 2020
10
Surgical Outcomes of Laparoscopic and Open D3 Dissection for Clinical Stage II/III Descending Colon Cancer. 61
32132081 2020
11
[Single-Incision Laparoscopic Colectomy for Descending Colon Cancer in a Patient with a Horseshoe Kidney]. 61
32381969 2020
12
[Descending Colon Cancer with Synchronous Solitary Small Intestinal Metastasis-A Case Report]. 61
32381878 2020
13
Performance comparison between MRI and CT for local staging of sigmoid and descending colon cancer. 61
31743882 2019
14
[A Case of Nephrotic Syndrome Induced by FOLFIRI plus Ramucirumab for Metastatic Descending Colon Cancer]. 61
32156863 2019
15
[Two Cases of Advanced Colorectal Cancer Achieving Complete Response by FOLFOXIRI plus Bevacizumab-A Case Report]. 61
32156948 2019
16
Cranial-first approach of laparoscopic left colectomy for T4 descending colon cancer invading the Gerota's fascia. 61
31659502 2019
17
[Anatomical relationship between fascia propria of the rectum and visceral pelvic fascia in the view of continuity of fasciae]. 61
31630492 2019
18
Distribution of lymph node metastasis and the extent of lymph node dissection in descending colon cancer patients. 61
31452333 2019
19
[Postoperative Adjuvant Chemotherapy for Descending Colon Cancer Treated with Imatinib for Chronic Myeloid Leukemia]. 61
31501379 2019
20
3D printed model-based simulation of laparoscopic surgery for descending colon cancer with a concomitant abdominal aortic aneurysm. 61
31440952 2019
21
Simultaneous laparoscopic left hemicolectomy and spleen-preserving distal pancreatectomy for descending colon cancer with pancreatic invasion. 61
30264485 2019
22
Randomized controlled trial to evaluate laparoscopic versus open surgery in transverse and descending colon cancer patients. 61
31102008 2019
23
[Feasibility and safety of the medial approach "four-step method" in the laparoscopic mobilization of splenic flexure]. 61
31302966 2019
24
Laparoscopic colectomy after transcatheter aortic valve implantation in an elderly patient with obstructive descending colon cancer and severe aortic stenosis: a case report. 61
31236739 2019
25
[Usefulness of CT Colonography for a Patient with Three Synchronous Primary Descending Colon Cancers]. 61
31189825 2019
26
[Two Cases of Colorectal Liver Metastasis with Localized Biliary Dilatation]. 61
30914606 2019
27
Three-dimensional computed tomographic angiography with computed tomographic colonography for laparoscopic colorectal surgery. 61
30218252 2018
28
[Laparoscopy-Assisted Surgery for Descending Colon Cancer in a Patient with Persistent Descending Mesocolon-A Case Report]. 61
30692369 2018
29
[A Case of a One-Stage Resection and Anastomosis Procedure for a Descending Colon Cancer Ileus after Decompression with a Trans-Nasal Ileus Tube]. 61
30587734 2018
30
Necrotizing fasciitis of the thigh due to penetrated descending colon cancer: a case report. 61
30478748 2018
31
Robotic left colectomy with complete mesocolectomy for splenic flexure and descending colon cancer, compared with a laparoscopic procedure. 61
29790253 2018
32
Strategy of laparoscopic surgery for colon cancer of the splenic flexure: a novel approach. 61
29075964 2018
33
Mixed Neuroendocrine Carcinoma and Squamous Cell Carcinoma of the Colon: Case Report and Literature Review. 61
30022911 2018
34
[A Case of Local Recurrence of Descending Colon Cancer with Ileus Obstruction and Lung, Liver and Brain Metastasis]. 61
29650833 2018
35
[A Case of Transduodenal Ampullectomy for an Ampullary Neoplasm Coexisting with Gastric and Colon Cancer]. 61
29483427 2018
36
[A Case of Ischemic Colitis Four Months after Laparoscopic Left Hemicolectomy Preserving Superior Rectal Artery]. 61
29483428 2018
37
[A Case of a Hepatic Inflammatory Pseudotumor Difficult to Distinguish from Metastatic Liver Cancer and Potentially Caused by Colon Diverticula]. 61
29394857 2017
38
[Hepatic Lateral Segmentectomy for Management of Liver and Adrenal Abscess Following a Laparoscopy-Assisted Left Hemicolectomy - A Case Report]. 61
29394558 2017
39
[Optimal Dissection of the Intestinal Tract and Preservation of Vascular Supply in Left Hemicolectomy Using Simulation Computed Tomography Colonography]. 61
29394796 2017
40
[A Case of Conversion Surgery for Unresectable Colorectal Liver Metastases, Following Effective Combined Chemotherapy with Molecular Targeting Agents]. 61
29394604 2017
41
[A Case of Local Recurrence with Negative FDG/PET Findings after a Total Proctocolectomy for Ulcerative Colitis Associated with Colon Cancer with Retroperitoneal Penetration]. 61
29394669 2017
42
Mucosa-associated microbiota signature in colorectal cancer. 61
28600626 2017
43
Laparoscopic versus open resection for transverse and descending colon cancer: Short-term and long-term outcomes of a multicenter retrospective study of 1830 patients. 61
28387060 2017
44
[A Case of Mediastinal Lymph Node Metastasis from Liver Metastasis of Colon Cancer]. 61
28790266 2017
45
[Endoscopic metallic stent followed by elective laparoscopic surgery for malignant colorectal obstruction]. 61
28643316 2017
46
Cholecystectomy can increase the risk of colorectal cancer: A meta-analysis of 10 cohort studies. 61
28771518 2017
47
Aggressive resection of frequent peritoneal recurrences in colorectal cancer contributes to long-term survival. 61
28008206 2016
48
[A Case of Mucinous Adenocarcinoma of the Descending Colon with Extramural Progression]. 61
28133301 2016
49
[A Case of Laparoscopic Resection of a Lymph Node Recurrence after Surgery for Descending Colon Cancer]. 61
28133303 2016
50
[A Case of Intussusception Caused by Descending Colon Cancer]. 61
28133257 2016

Variations for Descending Colon Cancer

Expression for Descending Colon Cancer

Search GEO for disease gene expression data for Descending Colon Cancer.

Pathways for Descending Colon Cancer

GO Terms for Descending Colon Cancer

Biological processes related to Descending Colon Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of MAP kinase activity GO:0043406 9.16 KRAS HRAS
2 regulation of long-term neuronal synaptic plasticity GO:0048169 8.96 KRAS HRAS
3 response to isolation stress GO:0035900 8.62 KRAS HRAS

Sources for Descending Colon Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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