MCID: DSC005
MIFTS: 36

Descending Colon Cancer

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Descending Colon Cancer

MalaCards integrated aliases for Descending Colon Cancer:

Name: Descending Colon Cancer 12 15
Malignant Neoplasm of Descending Colon 74
Malignant Tumor of Descending Colon 12
Malignant Neoplasm of Left Colon 12
Ca Descending Colon 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12190
ICD9CM 36 153.2
SNOMED-CT 69 93771007
ICD10 34 C18.6
UMLS 74 C0153435

Summaries for Descending Colon Cancer

MalaCards based summary : Descending Colon Cancer, also known as malignant neoplasm of descending colon, is related to splenic flexure cancer and kernicterus. An important gene associated with Descending Colon Cancer is GLE1 (GLE1 RNA Export Mediator), and among its related pathways/superpathways are Porphyrin and chlorophyll metabolism and Reelin Pathway (Cajal-Retzius cells). The drug Cola has been mentioned in the context of this disorder. Affiliated tissues include colon, appendix and breast, and related phenotype is Negative genetic interaction between PTTG1-/- and PTTG1+/+.

Related Diseases for Descending Colon Cancer

Diseases related to Descending Colon Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Related Disease Score Top Affiliating Genes
1 splenic flexure cancer 10.3 DCXR EZR GLE1
2 kernicterus 10.2 UGT1A1 UGT1A6
3 colorectal cancer 10.2
4 pigmentation disease 10.2 UGT1A1 UGT1A6
5 adenosquamous colon carcinoma 10.2 CDX2 MSH2
6 dihydropyrimidine dehydrogenase deficiency 10.2 UGT1A1 UGT1A6
7 diverticulitis of colon 10.2 DCXR STC1
8 ovary neuroendocrine neoplasm 10.2 CDX2 KRT7
9 appendix adenocarcinoma 10.2 CDX2 KRT7
10 crigler-najjar syndrome, type i 10.2 SLC35A2 UGT1A1 UGT1A6
11 glandular cystitis 10.2 CDX2 KRT7
12 duodenum adenocarcinoma 10.2 CDX2 KRT7
13 bilirubin metabolic disorder 10.2 SLC35A2 UGT1A1 UGT1A6
14 epithelial predominant wilms' tumor 10.2 CDX2 KRT7
15 jejunal adenocarcinoma 10.2 CDX2 KRT7
16 nasal cavity cancer 10.2 CDX2 KRT7
17 ovarian mucinous adenocarcinoma 10.2 CDX2 KRT7
18 appendix disease 10.2 CDX2 KRT7
19 gastric diffuse adenocarcinoma 10.1 CDX2 KRT7
20 bladder adenocarcinoma 10.1 CDX2 KRT7
21 nasal cavity adenocarcinoma 10.1 CDX2 KRT7
22 chronic cystitis 10.1 CDX2 KRT7
23 anal canal adenocarcinoma 10.1 CDX2 KRT7
24 bilirubin, serum level of, quantitative trait locus 1 10.1 UGT1A1 UGT1A6 UGT1A8
25 crigler-najjar syndrome, type ii 10.1 UGT1A1 UGT1A6 UGT1A8
26 gilbert syndrome 10.1 UGT1A1 UGT1A6 UGT1A8
27 mucinous bronchioloalveolar adenocarcinoma 10.1 CDX2 KRT7
28 ampulla of vater adenocarcinoma 10.1 CDX2 KRT7
29 endocervical adenocarcinoma 10.1 CDX2 KRT7
30 appendix cancer 10.1 CDX2 KRT7
31 prostatic acinar adenocarcinoma 10.1 CDX2 KRT7
32 cystic teratoma 10.0 CDX2 KRT7
33 anus cancer 10.0 CDX2 DCXR KRT7
34 horseshoe kidney 10.0 CDX2 KRT7
35 anal paget's disease 10.0 CDX2 CEACAM5
36 duodenum cancer 10.0 CDX2 KRT7
37 leber congenital amaurosis 4 10.0 SLC35A2 UGT1A1 UGT1A6 UGT1A8
38 atypical choroid plexus papilloma 10.0 APP KRT7
39 adenocarcinoma in situ 10.0 CDX2 KRT7
40 gastric signet ring cell adenocarcinoma 10.0 CDX2 CEACAM5
41 cutaneous mucoepidermoid carcinoma 9.9 CEACAM5 KRT7
42 anal gland adenocarcinoma 9.9 CEACAM5 KRT7
43 malignant spiradenoma 9.9 CEACAM5 KRT7
44 bile duct mucoepidermoid carcinoma 9.9 CEACAM5 KRT7
45 cutaneous adenocystic carcinoma 9.9 CEACAM5 KRT7
46 nodular hidradenoma 9.9 CEACAM5 KRT7
47 cecum adenocarcinoma 9.9 CDX2 KRT7 MSH2
48 vulval paget's disease 9.9 CEACAM5 KRT7
49 small intestine cancer 9.9 CDX2 KRT7 MSH2
50 bile duct cystadenocarcinoma 9.9 CEACAM5 KRT7

Comorbidity relations with Descending Colon Cancer via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Colorectal Cancer
Deficiency Anemia Intestinal Obstruction
Paralytic Ileus Rectosigmoid Junction Neoplasm

Graphical network of the top 20 diseases related to Descending Colon Cancer:



Diseases related to Descending Colon Cancer

Symptoms & Phenotypes for Descending Colon Cancer

GenomeRNAi Phenotypes related to Descending Colon Cancer according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Negative genetic interaction between PTTG1-/- and PTTG1+/+ GR00255-A-4 9.02 DCXR EZR MSH2 SLC12A2 SLC35A2

Drugs & Therapeutics for Descending Colon Cancer

Drugs for Descending Colon Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Cola Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Controlled Trial Between Laparoscopic and Open Surgery in Transverse and Descending Colon Cancer Patients Unknown status NCT01861691 Phase 2

Search NIH Clinical Center for Descending Colon Cancer

Genetic Tests for Descending Colon Cancer

Anatomical Context for Descending Colon Cancer

MalaCards organs/tissues related to Descending Colon Cancer:

42
Colon, Appendix, Breast, Prostate, Lymph Node, Spleen, Thymus

Publications for Descending Colon Cancer

Articles related to Descending Colon Cancer:

(show all 15)
# Title Authors Year
1
Randomized controlled trial to evaluate laparoscopic versus open surgery in transverse and descending colon cancer patients. ( 31102008 )
2019
2
Robotic left colectomy with complete mesocolectomy for splenic flexure and descending colon cancer, compared with a laparoscopic procedure. ( 29790253 )
2018
3
Simultaneous laparoscopic left hemicolectomy and spleen-preserving distal pancreatectomy for descending colon cancer with pancreatic invasion. ( 30264485 )
2018
4
Necrotizing fasciitis of the thigh due to penetrated descending colon cancer: a case report. ( 30478748 )
2018
5
Laparoscopic versus open resection for transverse and descending colon cancer: Short-term and long-term outcomes of a multicenter retrospective study of 1830 patients. ( 28387060 )
2017
6
A Case of Advanced Descending Colon Cancer in an Adult Patient with Intestinal Malrotation. ( 27042367 )
2016
7
Bowel strangulation caused by massive intraperitoneal adhesion due to effective chemotherapy for multiple peritoneal metastases originating from descending colon cancer. ( 27568034 )
2016
8
Novel emergency management of descending colon cancer presenting with retroperitoneal perforation. ( 24550634 )
2014
9
A rare case of perforated descending colon cancer complicated with a fistula and abscess of left iliopsoas and ipsilateral obturator muscle. ( 24744948 )
2014
10
A birth cohort analysis of the incidence of ascending and descending colon cancer in the United States, 1973-2008. ( 23535866 )
2013
11
Clinical outcomes of laparoscopic surgery for advanced transverse and descending colon cancer: a single-center experience. ( 22179459 )
2012
12
Adult Intussusception Caused by Descending Colon Cancer during Chemotherapy of Stomach Cancer Recurrence. ( 22423245 )
2012
13
Metastatic Small Bowel Tumor from Descending Colon Cancer with Extensive Hematogenous or Lymphogenous Spread: Survey of the Japanese Literature. ( 21060697 )
2010
14
Short-term Outcomes of a Laparoscopic Left Hemicolectomy for Descending Colon Cancer: Retrospective Comparison with an Open Left Hemicolectomy. ( 21152138 )
2010
15
Laparoscopic D3 lymph node dissection with preservation of the superior rectal artery for the treatment of proximal sigmoid and descending colon cancer. ( 17705727 )
2007

Variations for Descending Colon Cancer

Expression for Descending Colon Cancer

Search GEO for disease gene expression data for Descending Colon Cancer.

Pathways for Descending Colon Cancer

GO Terms for Descending Colon Cancer

Cellular components related to Descending Colon Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 9.93 APP CEACAM5 DCXR EZR GLE1 LRP6
2 apical plasma membrane GO:0016324 9.26 CEACAM5 EZR SLC12A2 STC1
3 astrocyte projection GO:0097449 8.62 APP EZR

Biological processes related to Descending Colon Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to glucocorticoid stimulus GO:0071385 9.43 STC1 UGT1A1
2 cellular response to cAMP GO:0071320 9.43 APP EZR STC1
3 cellular glucuronidation GO:0052695 9.4 UGT1A1 UGT1A6
4 retinoic acid metabolic process GO:0042573 9.37 UGT1A1 UGT1A8
5 flavone metabolic process GO:0051552 9.32 UGT1A1 UGT1A8
6 negative regulation of steroid metabolic process GO:0045939 9.16 UGT1A1 UGT1A8
7 xenobiotic glucuronidation GO:0052697 9.13 UGT1A1 UGT1A6 UGT1A8
8 flavonoid glucuronidation GO:0052696 8.8 UGT1A1 UGT1A6 UGT1A8

Molecular functions related to Descending Colon Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.85 APP CEACAM5 DCXR EZR GLE1 LRP6
2 protein homodimerization activity GO:0042803 9.8 CEACAM5 LRP6 MSH2 UGT1A1 UGT1A6 UGT1A8
3 transferase activity, transferring hexosyl groups GO:0016758 9.43 UGT1A1 UGT1A6 UGT1A8
4 steroid binding GO:0005496 9.4 UGT1A1 UGT1A8
5 glucuronosyltransferase activity GO:0015020 9.33 UGT1A1 UGT1A6 UGT1A8
6 retinoic acid binding GO:0001972 9.13 UGT1A1 UGT1A6 UGT1A8
7 UDP-glycosyltransferase activity GO:0008194 8.8 UGT1A1 UGT1A6 UGT1A8

Sources for Descending Colon Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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