MCID: DSC005
MIFTS: 34

Descending Colon Cancer

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Descending Colon Cancer

MalaCards integrated aliases for Descending Colon Cancer:

Name: Descending Colon Cancer 12 15
Malignant Neoplasm of Descending Colon 74
Malignant Tumor of Descending Colon 12
Malignant Neoplasm of Left Colon 12
Ca Descending Colon 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12190
ICD9CM 36 153.2
SNOMED-CT 69 93771007
ICD10 34 C18.6
UMLS 74 C0153435

Summaries for Descending Colon Cancer

MalaCards based summary : Descending Colon Cancer, also known as malignant neoplasm of descending colon, is related to rectum squamous cell carcinoma and splenic flexure cancer. An important gene associated with Descending Colon Cancer is GLE1 (GLE1 RNA Export Mediator), and among its related pathways/superpathways are Porphyrin and chlorophyll metabolism and Reelin Pathway (Cajal-Retzius cells). The drug Cola has been mentioned in the context of this disorder. Affiliated tissues include colon, lymph node and spleen, and related phenotype is Negative genetic interaction between PTTG1-/- and PTTG1+/+.

Related Diseases for Descending Colon Cancer

Diseases related to Descending Colon Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
# Related Disease Score Top Affiliating Genes
1 rectum squamous cell carcinoma 10.2 DCXR SMUG1
2 splenic flexure cancer 10.2 DCXR EZR GLE1
3 rectosigmoid junction neoplasm 10.2 DCXR SMUG1
4 rectum adenocarcinoma 10.1 CEACAM5 DCXR
5 kernicterus 10.1 UGT1A1 UGT1A6
6 pigmentation disease 10.1 UGT1A1 UGT1A6
7 dihydropyrimidine dehydrogenase deficiency 10.1 UGT1A1 UGT1A6
8 anus cancer 10.1 DCXR SMUG1
9 anus disease 10.1 DCXR SMUG1
10 liver lymphoma 10.1 CEACAM5 SMUG1
11 splenic tuberculosis 10.1 CEACAM5 SMUG1
12 malignant acrospiroma 10.1 CEACAM5 SMUG1
13 malignant spiradenoma 10.1 CEACAM5 SMUG1
14 tolosa-hunt syndrome 10.0 CEACAM5 SMUG1
15 eccrine adenocarcinoma 10.0 CEACAM5 SMUG1
16 acetaminophen metabolism 10.0 UGT1A1 UGT1A6
17 colorectal cancer 10.0
18 benign childhood occipital epilepsy, gastaut type 10.0
19 crigler-najjar syndrome, type i 10.0 SLC35A2 UGT1A1 UGT1A6
20 pericardial tuberculosis 10.0 CEACAM5 SMUG1
21 bilirubin metabolic disorder 10.0 SLC35A2 UGT1A1 UGT1A6
22 prostate squamous cell carcinoma 10.0 CEACAM5 SMUG1
23 tuberculous peritonitis 10.0 CEACAM5 SMUG1
24 ascending colon cancer 10.0 MSH2 SMUG1
25 bilirubin, serum level of, quantitative trait locus 1 10.0 UGT1A1 UGT1A6 UGT1A8
26 crigler-najjar syndrome, type ii 10.0 UGT1A1 UGT1A6 UGT1A8
27 gilbert syndrome 10.0 UGT1A1 UGT1A6 UGT1A8
28 xanthogranulomatous cholecystitis 9.9 CEACAM5 SMUG1
29 cecum adenocarcinoma 9.9 MSH2 SMUG1
30 intussusception 9.9
31 fasciitis 9.9
32 necrotizing fasciitis 9.9
33 tracheal cancer 9.8 CEACAM5 SMUG1
34 intestinal benign neoplasm 9.8 CEACAM5 MSH2
35 leber congenital amaurosis 4 9.8 SLC35A2 UGT1A1 UGT1A6 UGT1A8
36 pleural disease 9.8 CEACAM5 SMUG1
37 alzheimer disease 2 9.8 APP SMUG1
38 intestinal disease 9.7 CEACAM5 MSH2 SMUG1
39 gastrointestinal system cancer 9.7 CEACAM5 MSH2 SMUG1
40 gastrointestinal system disease 9.7 CEACAM5 MSH2 SMUG1
41 esophageal disease 9.7 CEACAM5 SMUG1
42 gallbladder squamous cell carcinoma 9.6 APP CEACAM5 SMUG1
43 large intestine cancer 8.9 CEACAM5 DCXR MSH2 SLC35A2 SMUG1 UGT1A1

Comorbidity relations with Descending Colon Cancer via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Colorectal Cancer
Deficiency Anemia Intestinal Obstruction
Paralytic Ileus Rectosigmoid Junction Neoplasm

Graphical network of the top 20 diseases related to Descending Colon Cancer:



Diseases related to Descending Colon Cancer

Symptoms & Phenotypes for Descending Colon Cancer

GenomeRNAi Phenotypes related to Descending Colon Cancer according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Negative genetic interaction between PTTG1-/- and PTTG1+/+ GR00255-A-4 9.02 DCXR EZR MSH2 SLC12A2 SLC35A2

Drugs & Therapeutics for Descending Colon Cancer

Drugs for Descending Colon Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Cola Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Controlled Trial Between Laparoscopic and Open Surgery in Transverse and Descending Colon Cancer Patients Unknown status NCT01861691 Phase 2

Search NIH Clinical Center for Descending Colon Cancer

Genetic Tests for Descending Colon Cancer

Anatomical Context for Descending Colon Cancer

MalaCards organs/tissues related to Descending Colon Cancer:

42
Colon, Lymph Node, Spleen

Publications for Descending Colon Cancer

Articles related to Descending Colon Cancer:

(show all 14)
# Title Authors Year
1
Robotic left colectomy with complete mesocolectomy for splenic flexure and descending colon cancer, compared with a laparoscopic procedure. ( 29790253 )
2018
2
Simultaneous laparoscopic left hemicolectomy and spleen-preserving distal pancreatectomy for descending colon cancer with pancreatic invasion. ( 30264485 )
2018
3
Necrotizing fasciitis of the thigh due to penetrated descending colon cancer: a case report. ( 30478748 )
2018
4
Laparoscopic versus open resection for transverse and descending colon cancer: Short-term and long-term outcomes of a multicenter retrospective study of 1830 patients. ( 28387060 )
2017
5
Bowel strangulation caused by massive intraperitoneal adhesion due to effective chemotherapy for multiple peritoneal metastases originating from descending colon cancer. ( 27568034 )
2016
6
A Case of Advanced Descending Colon Cancer in an Adult Patient with Intestinal Malrotation. ( 27042367 )
2016
7
A rare case of perforated descending colon cancer complicated with a fistula and abscess of left iliopsoas and ipsilateral obturator muscle. ( 24744948 )
2014
8
Novel emergency management of descending colon cancer presenting with retroperitoneal perforation. ( 24550634 )
2014
9
A birth cohort analysis of the incidence of ascending and descending colon cancer in the United States, 1973-2008. ( 23535866 )
2013
10
Adult Intussusception Caused by Descending Colon Cancer during Chemotherapy of Stomach Cancer Recurrence. ( 22423245 )
2012
11
Clinical outcomes of laparoscopic surgery for advanced transverse and descending colon cancer: a single-center experience. ( 22179459 )
2012
12
Metastatic Small Bowel Tumor from Descending Colon Cancer with Extensive Hematogenous or Lymphogenous Spread: Survey of the Japanese Literature. ( 21060697 )
2010
13
Short-term Outcomes of a Laparoscopic Left Hemicolectomy for Descending Colon Cancer: Retrospective Comparison with an Open Left Hemicolectomy. ( 21152138 )
2010
14
Laparoscopic D3 lymph node dissection with preservation of the superior rectal artery for the treatment of proximal sigmoid and descending colon cancer. ( 17705727 )
2007

Variations for Descending Colon Cancer

Expression for Descending Colon Cancer

Search GEO for disease gene expression data for Descending Colon Cancer.

Pathways for Descending Colon Cancer

Pathways related to Descending Colon Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.81 DCXR UGT1A1 UGT1A6 UGT1A8
2 11.58 APP EZR LRP6
3
Show member pathways
11.4 UGT1A1 UGT1A6 UGT1A8
4 11.29 APP EZR LRP6
5
Show member pathways
11.25 UGT1A1 UGT1A6 UGT1A8
6 10.96 UGT1A1 UGT1A6
7
Show member pathways
10.88 UGT1A1 UGT1A6 UGT1A8
8 10.69 UGT1A6 UGT1A8
9
Show member pathways
10.33 UGT1A1 UGT1A6 UGT1A8

GO Terms for Descending Colon Cancer

Cellular components related to Descending Colon Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 9.4 APP CEACAM5 DCXR EZR GLE1 LRP6
2 membrane raft GO:0045121 9.33 APP EZR LRP6
3 astrocyte projection GO:0097449 8.96 APP EZR

Biological processes related to Descending Colon Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular glucuronidation GO:0052695 9.37 UGT1A1 UGT1A6
2 retinoic acid metabolic process GO:0042573 9.32 UGT1A1 UGT1A8
3 flavone metabolic process GO:0051552 9.26 UGT1A1 UGT1A8
4 negative regulation of steroid metabolic process GO:0045939 9.16 UGT1A1 UGT1A8
5 xenobiotic glucuronidation GO:0052697 9.13 UGT1A1 UGT1A6 UGT1A8
6 flavonoid glucuronidation GO:0052696 8.8 UGT1A1 UGT1A6 UGT1A8

Molecular functions related to Descending Colon Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.85 APP CEACAM5 DCXR EZR GLE1 LRP6
2 protein homodimerization activity GO:0042803 9.8 CEACAM5 LRP6 MSH2 UGT1A1 UGT1A6 UGT1A8
3 transferase activity, transferring glycosyl groups GO:0016757 9.63 UGT1A1 UGT1A6 UGT1A8
4 enzyme inhibitor activity GO:0004857 9.43 UGT1A1 UGT1A8
5 transferase activity, transferring hexosyl groups GO:0016758 9.43 UGT1A1 UGT1A6 UGT1A8
6 steroid binding GO:0005496 9.4 UGT1A1 UGT1A8
7 glucuronosyltransferase activity GO:0015020 9.33 UGT1A1 UGT1A6 UGT1A8
8 retinoic acid binding GO:0001972 9.13 UGT1A1 UGT1A6 UGT1A8
9 UDP-glycosyltransferase activity GO:0008194 8.8 UGT1A1 UGT1A6 UGT1A8

Sources for Descending Colon Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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