MCID: DSC005
MIFTS: 31

Descending Colon Cancer

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Descending Colon Cancer

MalaCards integrated aliases for Descending Colon Cancer:

Name: Descending Colon Cancer 12 15
Malignant Neoplasm of Descending Colon 73
Malignant Tumor of Descending Colon 12
Malignant Neoplasm of Left Colon 12
Ca Descending Colon 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12190
ICD10 33 C18.6
ICD9CM 35 153.2
UMLS 73 C0153435

Summaries for Descending Colon Cancer

MalaCards based summary : Descending Colon Cancer, also known as malignant neoplasm of descending colon, is related to splenic flexure cancer and rectum squamous cell carcinoma. An important gene associated with Descending Colon Cancer is GLE1 (GLE1, RNA Export Mediator), and among its related pathways/superpathways are Porphyrin and chlorophyll metabolism and Aryl Hydrocarbon Receptor Pathway. The drug Cola has been mentioned in the context of this disorder. Affiliated tissues include colon and lymph node.

Related Diseases for Descending Colon Cancer

Diseases related to Descending Colon Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
# Related Disease Score Top Affiliating Genes
1 splenic flexure cancer 10.4 DCXR GLE1 PCLO
2 rectum squamous cell carcinoma 10.4 DCXR SMUG1
3 bilirubin, serum level of, quantitative trait locus 1 10.3 UGT1A1 UGT1A6
4 rectosigmoid junction neoplasm 10.3 DCXR SMUG1
5 kernicterus 10.3 UGT1A1 UGT1A6
6 pigmentation disease 10.3 UGT1A1 UGT1A6
7 rectum adenocarcinoma 10.3 CEACAM5 DCXR
8 dihydropyrimidine dehydrogenase deficiency 10.2 UGT1A1 UGT1A6
9 crigler-najjar syndrome, type ii 10.2 UGT1A1 UGT1A6
10 liver lymphoma 10.2 CEACAM5 SMUG1
11 splenic tuberculosis 10.1 CEACAM5 SMUG1
12 gallbladder squamous cell carcinoma 10.1 CEACAM5 SMUG1
13 malignant spiradenoma 10.1 CEACAM5 SMUG1
14 lacrimal apparatus disease 10.1 CDSN DCXR
15 tolosa-hunt syndrome 10.1 CEACAM5 SMUG1
16 gastric signet ring cell adenocarcinoma 10.1 CEACAM5 SMUG1
17 eccrine adenocarcinoma 10.1 CEACAM5 SMUG1
18 femoral neuropathy 10.1 CEACAM5 SMUG1
19 pericardial tuberculosis 10.1 CEACAM5 SMUG1
20 crigler-najjar syndrome, type i 10.0 SLC35A2 UGT1A1 UGT1A6
21 bilirubin metabolic disorder 10.0 SLC35A2 UGT1A1 UGT1A6
22 prostate squamous cell carcinoma 10.0 CEACAM5 SMUG1
23 tuberculous peritonitis 10.0 CEACAM5 SMUG1
24 acetaminophen metabolism 10.0 UGT1A1 UGT1A6
25 xanthogranulomatous cholecystitis 9.9 CEACAM5 SMUG1
26 cecum adenocarcinoma 9.8 MSH2 SMUG1
27 intussusception 9.8
28 gastric cancer 9.8
29 peritonitis 9.8
30 urethral benign neoplasm 9.7 APP CEACAM5
31 gilbert syndrome 9.6 UGT1A1 UGT1A6
32 alzheimer disease 2 9.5 APP SMUG1
33 intestinal benign neoplasm 9.5 CEACAM5 MSH2
34 female reproductive organ cancer 9.4 CEACAM5 MSH2 SMUG1
35 gastrointestinal system cancer 9.4 CEACAM5 MSH2 SMUG1
36 rectal neoplasm 9.0 CEACAM5 DCXR MSH2 SMUG1

Comorbidity relations with Descending Colon Cancer via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Colorectal Cancer
Deficiency Anemia Intestinal Obstruction
Paralytic Ileus Rectosigmoid Junction Neoplasm

Graphical network of the top 20 diseases related to Descending Colon Cancer:



Diseases related to Descending Colon Cancer

Symptoms & Phenotypes for Descending Colon Cancer

Drugs & Therapeutics for Descending Colon Cancer

Drugs for Descending Colon Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Cola Nutraceutical Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Controlled Trial Between Laparoscopic and Open Surgery in Transverse and Descending Colon Cancer Patients Unknown status NCT01861691 Phase 2

Search NIH Clinical Center for Descending Colon Cancer

Genetic Tests for Descending Colon Cancer

Anatomical Context for Descending Colon Cancer

MalaCards organs/tissues related to Descending Colon Cancer:

41
Colon, Lymph Node

Publications for Descending Colon Cancer

Articles related to Descending Colon Cancer:

(show all 12)
# Title Authors Year
1
Robotic left colectomy with complete mesocolectomy for splenic flexure and descending colon cancer, compared with a laparoscopic procedure. ( 29790253 )
2018
2
Laparoscopic versus open resection for transverse and descending colon cancer: Short-term and long-term outcomes of a multicenter retrospective study of 1830 patients. ( 28387060 )
2017
3
Bowel strangulation caused by massive intraperitoneal adhesion due to effective chemotherapy for multiple peritoneal metastases originating from descending colon cancer. ( 27568034 )
2016
4
A Case of Advanced Descending Colon Cancer in an Adult Patient with Intestinal Malrotation. ( 27042367 )
2016
5
A rare case of perforated descending colon cancer complicated with a fistula and abscess of left iliopsoas and ipsilateral obturator muscle. ( 24744948 )
2014
6
Novel emergency management of descending colon cancer presenting with retroperitoneal perforation. ( 24550634 )
2014
7
A birth cohort analysis of the incidence of ascending and descending colon cancer in the United States, 1973-2008. ( 23535866 )
2013
8
Adult Intussusception Caused by Descending Colon Cancer during Chemotherapy of Stomach Cancer Recurrence. ( 22423245 )
2012
9
Clinical outcomes of laparoscopic surgery for advanced transverse and descending colon cancer: a single-center experience. ( 22179459 )
2012
10
Metastatic Small Bowel Tumor from Descending Colon Cancer with Extensive Hematogenous or Lymphogenous Spread: Survey of the Japanese Literature. ( 21060697 )
2010
11
Short-term Outcomes of a Laparoscopic Left Hemicolectomy for Descending Colon Cancer: Retrospective Comparison with an Open Left Hemicolectomy. ( 21152138 )
2010
12
Laparoscopic D3 lymph node dissection with preservation of the superior rectal artery for the treatment of proximal sigmoid and descending colon cancer. ( 17705727 )
2007

Variations for Descending Colon Cancer

Expression for Descending Colon Cancer

Search GEO for disease gene expression data for Descending Colon Cancer.

Pathways for Descending Colon Cancer

GO Terms for Descending Colon Cancer

Cellular components related to Descending Colon Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 9.36 APP CEACAM5 DCXR GLE1 LRP6 MSH2

Biological processes related to Descending Colon Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular glucuronidation GO:0052695 9.16 UGT1A1 UGT1A6
2 xenobiotic glucuronidation GO:0052697 8.96 UGT1A1 UGT1A6
3 flavonoid glucuronidation GO:0052696 8.62 UGT1A1 UGT1A6

Molecular functions related to Descending Colon Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.72 APP CEACAM5 DCXR GLE1 LRP6
2 glucuronosyltransferase activity GO:0015020 9.26 UGT1A1 UGT1A6
3 retinoic acid binding GO:0001972 9.16 UGT1A1 UGT1A6
4 protein homodimerization activity GO:0042803 9.1 CDSN CEACAM5 LRP6 MSH2 UGT1A1 UGT1A6
5 UDP-glycosyltransferase activity GO:0008194 8.96 UGT1A1 UGT1A6

Sources for Descending Colon Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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