DIG
MCID: DSM006
MIFTS: 28

Desmoplastic Infantile Ganglioglioma (DIG)

Categories: Rare diseases

Aliases & Classifications for Desmoplastic Infantile Ganglioglioma

MalaCards integrated aliases for Desmoplastic Infantile Ganglioglioma:

Name: Desmoplastic Infantile Ganglioglioma 53 73
Dig 53

Classifications:



External Ids:

UMLS 73 C1321878

Summaries for Desmoplastic Infantile Ganglioglioma

NIH Rare Diseases : 53 Desmoplastic infantile gangliomas (DIGs) are rare brain tumors that are normally located in the frontal or parietal lobes of the brain. They are usually diagnosed before 18 months of age with most infants presenting with a short duration of symptoms. Although seizures are not commonly observed, a bulging fontanelle, rapid head growth, vomiting, and a sunset sign are usually noted. The standard treatment for DIGs is surgical resection (surgical procedure in which the portion of the brain with the tumor is removed).

MalaCards based summary : Desmoplastic Infantile Ganglioglioma, also known as dig, is related to ganglioglioma and pleomorphic xanthoastrocytoma, and has symptoms including seizures An important gene associated with Desmoplastic Infantile Ganglioglioma is GFAP (Glial Fibrillary Acidic Protein), and among its related pathways/superpathways are Neuroscience and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include brain, parietal lobe and heart, and related phenotype is normal.

Related Diseases for Desmoplastic Infantile Ganglioglioma

Diseases related to Desmoplastic Infantile Ganglioglioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Related Disease Score Top Affiliating Genes
1 ganglioglioma 31.4 GFAP SYP
2 pleomorphic xanthoastrocytoma 30.1 GFAP SYP
3 astrocytoma 10.4
4 desmoplastic infantile astrocytoma 10.1
5 autonomic nervous system benign neoplasm 10.0 MYCN SYP
6 nodular ganglioneuroblastoma 10.0 MYCN SYP
7 ganglioneuroblastoma 9.9 MYCN SYP
8 nervous system benign neoplasm 9.9 GFAP SYP
9 extraventricular neurocytoma 9.9 GFAP SYP
10 lung combined type small cell carcinoma 9.9 GFAP SYP
11 cellular ependymoma 9.9 GFAP SYP
12 ependymoma 9.9 GFAP SYP
13 chordoid meningioma 9.9 GFAP SYP
14 central nervous system primitive neuroectodermal neoplasm 9.9 GFAP SYP
15 clear cell ependymoma 9.9 GFAP SYP
16 chiari malformation 9.9 GFAP SYP
17 dysembryoplastic neuroepithelial tumor 9.9 GFAP SYP
18 cerebral neuroblastoma 9.9 GFAP SYP
19 subependymal glioma 9.9 GFAP SYP
20 astroblastoma 9.9 GFAP SYP
21 cerebral ventricle cancer 9.9 GFAP SYP
22 pineal gland cancer 9.9 GFAP SYP
23 melanotic neuroectodermal tumor 9.9 GFAP SYP
24 benign ependymoma 9.9 GFAP SYP
25 angiocentric glioma 9.9 GFAP SYP
26 obstructive hydrocephalus 9.9 GFAP SYP
27 cerebral primitive neuroectodermal tumor 9.9 MYCN SYP
28 hydrocephalus 9.9 GFAP SYP
29 medulloepithelioma 9.9 GFAP SYP
30 pineocytoma 9.9 GFAP SYP
31 subependymoma 9.9 GFAP SYP
32 anaplastic ependymoma 9.9 GFAP SYP
33 benign glioma 9.9 GFAP SYP
34 childhood oligodendroglioma 9.9 GFAP SYP
35 oligodendroglioma 9.9 GFAP SYP
36 tanycytic ependymoma 9.9 GFAP SYP
37 tracheoesophageal fistula 9.9 MYCN SYP
38 papillary ependymoma 9.9 GFAP SYP
39 pineoblastoma 9.9 GFAP SYP
40 infratentorial cancer 9.9 MYCN SYP
41 papilloma of choroid plexus 9.9 GFAP SYP
42 central neurocytoma 9.9 GFAP SYP
43 binswanger's disease 9.9 GFAP SYP
44 cystic teratoma 9.9 GFAP SYP
45 teratoma 9.9 GFAP SYP
46 subependymal giant cell astrocytoma 9.9 GFAP SYP
47 cerebellar liponeurocytoma 9.9 GFAP SYP
48 pilomyxoid astrocytoma 9.9 GFAP SYP
49 cerebellopontine angle tumor 9.9 GFAP SYP
50 optic nerve glioma 9.9 GFAP SYP

Graphical network of the top 20 diseases related to Desmoplastic Infantile Ganglioglioma:



Diseases related to Desmoplastic Infantile Ganglioglioma

Symptoms & Phenotypes for Desmoplastic Infantile Ganglioglioma

UMLS symptoms related to Desmoplastic Infantile Ganglioglioma:


seizures

MGI Mouse Phenotypes related to Desmoplastic Infantile Ganglioglioma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 normal MP:0002873 8.8 GFAP MYCN SYP

Drugs & Therapeutics for Desmoplastic Infantile Ganglioglioma

Search Clinical Trials , NIH Clinical Center for Desmoplastic Infantile Ganglioglioma

Genetic Tests for Desmoplastic Infantile Ganglioglioma

Anatomical Context for Desmoplastic Infantile Ganglioglioma

MalaCards organs/tissues related to Desmoplastic Infantile Ganglioglioma:

41
Brain, Parietal Lobe, Heart, Liver, Lung, Pineal, Testes

Publications for Desmoplastic Infantile Ganglioglioma

Articles related to Desmoplastic Infantile Ganglioglioma:

(show top 50) (show all 374)
# Title Authors Year
1
A Randomized Trial of Binocular Dig Rush Game Treatment for Amblyopia in Children Aged 7 to 12 Years of Age. ( 30352226 )
2018
2
Desmoplastic Infantile Ganglioglioma/Astrocytoma (DIG/DIA) Are Distinct Entities with Frequent BRAFV600 Mutations. ( 30006355 )
2018
3
Novel BRAF alteration in desmoplastic infantile ganglioglioma with response to targeted therapy. ( 30396366 )
2018
4
Unacknowledged adverse transfusion reactions: Are they a mine to dig? ( 28690037 )
2018
5
'These people who dig roots in the forests cannot treat HIV': Women and men in Durban, South Africa, reflect on traditional medicine and antiretroviral drugs. ( 28793809 )
2018
6
Spike-In Normalization of ChIP Data Using DNA-DIG-Antibody Complex. ( 29027177 )
2018
7
When DNA Topology Turns Deadly - RNA Polymerases Dig in Their R-Loops to Stand Their Ground: New Positive and Negative (Super)Twists in the Replication-Transcription Conflict. ( 29179918 )
2018
8
Catalyst-Controlled Structural Divergence: Selective Intramolecular 7-endo-dig and 6-exo-dig Post-Ugi Cyclization for the Synthesis of Benzoxazepinones and Benzoxazinones. ( 29181970 )
2018
9
Behavioral Evolution: Can You Dig It? ( 29316414 )
2018
10
Gold-Catalyzed Selective 6-exo-dig and 7-endo-dig Cyclizations of Alkyn-Tethered Indoles To Prepare Rutaecarpine Derivatives. ( 29394066 )
2018
11
Role of tumor-infiltrating lymphocytes in patients with solid tumors: Can a drop dig a stone? ( 29395859 )
2018
12
Corrigendum to "Differences in liver stiffness values obtained with new ultrasound elastography machines and fibroscan: A comparative study" [Dig. Liver Dis. 49 (2017) 802-808]. ( 29625910 )
2018
13
Stereoselective and regioselective 5-exo-dig cyclization of 8-alkynylnaphthalen-1-amines for the synthesis of (E)-2-(arylthio)alkylene-1,2-dihydrobenzo[cd]indoles. ( 29632928 )
2018
14
Probabilistic non-carcinogenic and carcinogenic risk assessments (Monte Carlo simulation method) of the measured acrylamide content in Tah-dig using QuEChERS extraction and UHPLC-MS/MS. ( 29792981 )
2018
15
Merging " Anti-Baldwin" 3- Exo-Dig Cyclization with 1,2-Alkynyl Migration for Radical Alkylalkynylation of Unactivated Olefins. ( 29856223 )
2018
16
A novel electrochemiluminescence biosensor based on S-doped yttrium oxide ultrathin nanosheets for the detection of anti-Dig antibodies. ( 29872773 )
2018
17
Regioselective 5-exo-dig oxy-cyclization of 2-alkynylbenzamide for the synthesis of isobenzofuran-1-imines and isobenzofuran. ( 29873384 )
2018
18
Dig seeks site of first English settlement in the New World. ( 29880667 )
2018
19
Congress Readying User Fee Program for OTC Products: Money Needed to Dig FDA Out of Its Review Ditch. ( 30186025 )
2018
20
How deep do we dig? Formal explanations as placeholders for inherent explanations. ( 30189296 )
2018
21
Tandem Palladium-Catalyzed 6- exo- dig Oxocyclization Coupling of δ-Acetylenic β-Ketoesters with Aryl Bromides and Chlorides: Route to Substituted Dihydropyrans. ( 30204434 )
2018
22
The Dig It Check It model. ( 30238027 )
2018
23
FeCl3-promoted tandem 1,4-conjugate addition/6-endo-dig cyclization/oxidation of propargylamines and benzoylacetonitriles/malononitriles: direct access to functionalized 2-aryl-4H-chromenes. ( 30255179 )
2018
24
Silyl Group-Directed 6-exo-dig Iodocyclization of Homopropargylic Carbamates and Amides. ( 30311697 )
2018
25
Bringing Darkness to Light: Intrinsic Disorder as a Means to Dig into the Dark Proteome. ( 30334344 )
2018
26
Do subterranean mammals use the Earth's magnetic field as a heading indicator to dig straight tunnels? ( 30402349 )
2018
27
DIG-seq: a genome-wide CRISPR off-target profiling method using chromatin DNA. ( 30413470 )
2018
28
Domino reaction of a gold catalyzed 5-endo-dig cyclization and a [3,3]-sigmatropic rearrangement towards polysubstituted pyrazoles. ( 30515488 )
2018
29
Gold(i)-catalyzed 6-endo-dig azide-yne cyclization: efficient access to 2H-1,3-oxazines. ( 27990524 )
2017
30
Gold-Catalyzed Intramolecular Regioselective 7-exo-dig Cyclization To Access 3-Methylene-3,4-dihydrobenzo[b]oxepinones. ( 28001425 )
2017
31
Dietary Intervention for Glucose Tolerance In Teens (DIG IT): Protocol of a randomized controlled trial using health coaching to prevent youth-onset type 2 diabetes. ( 28011388 )
2017
32
Colonic Endometriosis: Dig Deeper for Diagnosis. ( 28270880 )
2017
33
Altering the Cyclization Modes: Temperature-Dependent Intramolecular 7-Endo-Dig vs 6-Endo-Dig Electrophilic Ring Closures. ( 28271894 )
2017
34
Construction of the septahydroxylated ABC-ring system of dihydro-β-agarofurans: application of 6-exo-dig radical cyclization. ( 28345082 )
2017
35
Changing the path of least resistance, or access to endo-dig products via a sequence of three exo-trig transition states: electronic effects in homoallyic ring expansion cascades of alkenyl isonitriles. ( 28398443 )
2017
36
Regioselective 6-endo-dig iodocyclization: an accessible approach for iodo-benzo[a]phenazines. ( 28516995 )
2017
37
Silver-mediated radical 5-exo-dig cyclization of 2-alkynylbenzonitriles: synthesis of phosphinylated 1-indenones. ( 28548155 )
2017
38
Double Gold Activation of 1-Ethynyl-2-(Phenylethynyl)Benzene Toward 5-exo-dig and 6-endo-dig Cyclization Reactions. ( 28593693 )
2017
39
Paediatrics: Integrating genomics to dig deeper into Wilms tumour biology. ( 29068437 )
2017
40
Facile access to functionalized indenes and fused quinolines by regioselective 5-enolexo-dig Michael addition and cyclization reactions. ( 29085944 )
2017
41
Indium-Catalyzed Intramolecular Hydroamidation of Alkynes: An Exo-Dig Cyclization for the Synthesis of Pyranoquinolines through Post-Transformational Reaction. ( 29087201 )
2017
42
One-Pot Synthesis of α-Carbonyl Bicyclic Furans via a Sequential Diels-Alder/5-Exo-Dig Cyclization/Oxidation Reaction. ( 29111730 )
2017
43
Co(OAc)2-Catalyzed Trifluoromethylation and C(3)-Selective Arylation of 2-(Propargylamino)pyridines via a 6-Endo-Dig Cyclization. ( 29116802 )
2017
44
Lewis Acid Mediated "endo-dig" Hydroalkoxylation-Reduction on Internal Alkynols for the Stereoselective Synthesis of Cyclic Ethers and 1,4-Oxazepanes. ( 29166034 )
2017
45
Resuscitation outcomes consortium (ROC) studies dig deep into the science of CPR. ( 29206401 )
2017
46
Scratching the Surface in Autoimmune Epilepsy: It is the Time to Dig Deeper, But How? ( 29225526 )
2017
47
Chaco Canyon Dig Unearths Ethical Concerns. ( 29745246 )
2017
48
Supratentorial tumors typical of the infantile age: desmoplastic infantile ganglioglioma (DIG) and astrocytoma (DIA). A review. ( 27659826 )
2016
49
Desmoplastic infantile ganglioglioma with focal cortical dysplasia: A rare double pathology in an infant with history of seizures. ( 26991995 )
2016
50
Diffusion, Perfusion, and Histopathologic Characteristics of Desmoplastic Infantile Ganglioglioma. ( 27761184 )
2016

Variations for Desmoplastic Infantile Ganglioglioma

Expression for Desmoplastic Infantile Ganglioglioma

Search GEO for disease gene expression data for Desmoplastic Infantile Ganglioglioma.

Pathways for Desmoplastic Infantile Ganglioglioma

Pathways related to Desmoplastic Infantile Ganglioglioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.33 GFAP MYCN SYP
2 10.85 GFAP SYP

GO Terms for Desmoplastic Infantile Ganglioglioma

Molecular functions related to Desmoplastic Infantile Ganglioglioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kinase binding GO:0019900 8.62 GFAP MYCN

Sources for Desmoplastic Infantile Ganglioglioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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