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MCID: DTR001
MIFTS: 37

Detrusor Sphincter Dyssynergia

Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Detrusor Sphincter Dyssynergia

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MalaCards integrated aliases for Detrusor Sphincter Dyssynergia:

Name: Detrusor Sphincter Dyssynergia 12 15
Detrusor and Sphincter Dyssynergia 70

External Ids:

Disease Ontology 12 DOID:12145
ICD9CM 34 596.55
SNOMED-CT 67 236655005
UMLS 70 C0341747
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Summaries for Detrusor Sphincter Dyssynergia

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MalaCards based summary : Detrusor Sphincter Dyssynergia, also known as detrusor and sphincter dyssynergia, is related to low compliance bladder and neurogenic bladder, and has symptoms including dysuria and urgency of micturition. An important gene associated with Detrusor Sphincter Dyssynergia is P2RX3 (Purinergic Receptor P2X 3), and among its related pathways/superpathways are Peptide ligand-binding receptors and Calcium signaling pathway. The drugs Acetylcholine and abobotulinumtoxinA have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, smooth muscle and pituitary, and related phenotypes are behavior/neurological and cardiovascular system

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Related Diseases for Detrusor Sphincter Dyssynergia

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Diseases related to Detrusor Sphincter Dyssynergia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 98)
# Related Disease Score Top Affiliating Genes
1 low compliance bladder 31.1 P2RX3 NGF
2 neurogenic bladder 30.8 TRPV1 TAC1 P2RX3 P2RX2 NGF
3 cystitis 30.5 TRPV1 TAC1 P2RX3 NGF
4 constipation 30.3 TRPV1 TAC1 CALCA
5 interstitial cystitis 30.3 TRPV1 TAC1 P2RX3 NGF
6 amnestic disorder 29.9 NGF HTR1A
7 spinal cord injury 11.0
8 urinary tract infection 10.6
9 neural tube defects 10.5
10 vesicoureteral reflux 1 10.5
11 hydronephrosis 10.5
12 acute cystitis 10.5
13 quadriplegia 10.4
14 bladder neck obstruction 10.4
15 spinal cord disease 10.4
16 prostatic hypertrophy 10.3
17 bacteriuria 10.3
18 urethral stricture 10.3
19 paraplegia 10.3
20 herpes simplex 10.3
21 47,xyy 10.3
22 lesion of sciatic nerve 10.3 TRPV1 NGF
23 prurigo nodularis 10.3 TAC1 NGF
24 hyperhidrosis, gustatory 10.3 TRPV1 TAC1
25 cough variant asthma 10.3 TRPV1 NGF
26 punctate epithelial keratoconjunctivitis 10.2 TAC1 NGF
27 facial dermatosis 10.2 TRPV1 TAC1
28 anismus 10.2 TAC1 SNAP25
29 multiple sclerosis 10.2
30 multiple system atrophy 1 10.2
31 ataxia and polyneuropathy, adult-onset 10.2
32 prostatic hyperplasia, benign 10.2
33 parkinsonism 10.2
34 diarrhea 10.2
35 urethritis 10.2
36 prostatitis 10.2
37 rectum adenocarcinoma 10.2
38 wernicke encephalopathy 10.2
39 prostatic adenoma 10.2
40 myopathy 10.2
41 urinary tract obstruction 10.2
42 48,xyyy 10.2
43 autonomic dysfunction 10.2
44 encephalopathy 10.2
45 hypertonia 10.2
46 hinman syndrome 10.2
47 pseudopterygium 10.2 TRPV1 TAC1
48 dental pulp disease 10.2 TRPV1 TAC1
49 femoral cancer 10.1 TAC1 P2RX3 NGF
50 urethral syndrome 10.1 TAC1 P2RX3 NGF

Comorbidity relations with Detrusor Sphincter Dyssynergia via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Detrusor Sphincter Dyssynergia:



Diseases related to Detrusor Sphincter Dyssynergia
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Symptoms & Phenotypes for Detrusor Sphincter Dyssynergia

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UMLS symptoms related to Detrusor Sphincter Dyssynergia:


dysuria; urgency of micturition

MGI Mouse Phenotypes related to Detrusor Sphincter Dyssynergia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.9 AADAT ADCYAP1 ADRA1A HTR1A NGF P2RX3
2 cardiovascular system MP:0005385 9.56 ADRA1A HTR1A NGF P2RX2 P2RX3 SNAP25
3 nervous system MP:0003631 9.32 AADAT ADCYAP1 HTR1A NGF P2RX2 P2RX3
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Drugs & Therapeutics for Detrusor Sphincter Dyssynergia

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Drugs for Detrusor Sphincter Dyssynergia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational Phase 2 51-84-3 187
2 abobotulinumtoxinA Phase 2
3 Neurotransmitter Agents Phase 2
4 Cholinergic Agents Phase 2
5 Botulinum Toxins, Type A Phase 2
6 Botulinum Toxins Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clinical Interest of the Temporary Urethral Stent Allium " Bulbar Urethral Stent " in the Treatment of Detrusor Sphincter Dyssynergia Completed NCT02323243 Phase 1, Phase 2
2 Botulinum Toxin A Treatment of Detrusor External Sphincter Dyssynergia During Early Spinal Cord Injury (Protocol #H-20344) Terminated NCT00711087 Phase 2 BOTOX-A
3 Neuro-urological Outcome After Spinal Cord Injury Completed NCT01297660

Search NIH Clinical Center for Detrusor Sphincter Dyssynergia

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Genetic Tests for Detrusor Sphincter Dyssynergia

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Anatomical Context for Detrusor Sphincter Dyssynergia

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MalaCards organs/tissues related to Detrusor Sphincter Dyssynergia:

40
Spinal Cord, Smooth Muscle, Pituitary, Prostate, Brain, Bone, Kidney
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Publications for Detrusor Sphincter Dyssynergia

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Articles related to Detrusor Sphincter Dyssynergia:

(show top 50) (show all 597)
# Title Authors PMID Year
1
Fluoxetine, a selective serotonin reuptake inhibitor used clinically, improves bladder function in a mouse model of moderate spinal cord injury. 61
33642399 2021
2
High prevalence of lower urinary tract dysfunction in patients with Prader-Willi syndrome. 61
33811390 2021
3
[External sphincterotomy in neurological patients with detrusor sphincter dyssynergia: Short and mid-term results]. 61
33541792 2021
4
The Video-Urodynamic and Electrophysiological Characteristics in Patients With Traumatic Spinal Cord Injury. 61
33504122 2021
5
Lower urinary tract function in frontotemporal lobar degeneration: A preliminary observation. 61
32871389 2020
6
Factors associated with ultrasound diagnosed neurogenic bladder complications following spinal cord injury. 61
33219171 2020
7
A clinico-neurophysiological study of urogenital dysfunction in MOG-antibody transverse myelitis. 61
33046610 2020
8
The influence of bowel management on urodynamic findings in spina bifida children with detrusor overactivity and detrusor sphincter dyssynergia. 61
32376289 2020
9
Improvement of lower urinary tract function by a selective serotonin 5-HT1A receptor agonist, NLX-112, after chronic spinal cord injury. 61
32615138 2020
10
Pharmacotherapeutic management of lower urinary tract symptoms in Multiple Sclerosis patients. 61
32452702 2020
11
TASCI-transcutaneous tibial nerve stimulation in patients with acute spinal cord injury to prevent neurogenic detrusor overactivity: protocol for a nationwide, randomised, sham-controlled, double-blind clinical trial. 61
32792454 2020
12
Urodynamic Study Findings Prior to Myelomeningocele Repair in Neonates. 61
33531935 2020
13
A Single Cell Dissociation Approach for Molecular Analysis of Urinary Bladder in the Mouse Following Spinal Cord Injury. 61
32628176 2020
14
Spinal cord stimulation for the restoration of bladder function after spinal cord injury. 61
32754343 2020
15
Urethral dysfunction and alterations of nitric oxide mechanisms in streptozotocin-induced diabetic rats with or without low-dose insulin treatment. 61
32165214 2020
16
Is baseline routine renal ultrasound indicated for all MS patients? 61
31611266 2020
17
Urinary Symptoms and Bladder Dysfunction in Patients with Neuromyelitis Optica Spectrum Disorders: Evaluation with Urodynamics and Management. 61
32367978 2020
18
Prevalence of Lower Urinary Tract Symptoms in People with Multiple Sclerosis: A Systematic Review and Meta-analysis. 61
32410904 2020
19
Early sacral neuromodulation ameliorates urinary bladder function and structure in complete spinal cord injury minipigs. 61
31868966 2020
20
[Effects of alpha-1A/D adrenoceptor antagonist and phosphodiesterase type 5 inhibitor on bladder remodeling in rats with spinal cord injury]. 61
31902838 2020
21
Botulinum toxin therapy in children with neurogenic detrusor overactivity. 61
31905119 2020
22
The Therapeutic Effects and Pathophysiology of Botulinum Toxin A on Voiding Dysfunction Due to Urethral Sphincter Dysfunction. 61
31847090 2019
23
Therapeutic effects of inhibition of brain-derived neurotrophic factor on voiding dysfunction in mice with spinal cord injury. 61
31566429 2019
24
Functional MRI in patients with detrusor sphincter dyssynergia: Is the neural circuit affected? 61
31396992 2019
25
The impact of bowel management on the quality of life in children with spina bifida with overactive bladder and detrusor sphincter dyssynergia. 61
31202611 2019
26
Promise and the Pharmacological Mechanism of Botulinum Toxin A in Chronic Prostatitis Syndrome. 61
31614473 2019
27
The Spectrum of Clinical and Urodynamic Findings in Patients with Spinal Tuberculosis Exhibiting Lower Urinary Tract Symptoms, before and after Spinal Surgical Intervention with Antitubercular Treatment: A Prospective Study. 61
30909676 2019
28
Safety, Feasibility, and Efficacy of Transcutaneous Tibial Nerve Stimulation in Acute Spinal Cord Injury Neurogenic Bladder: A Randomized Control Pilot Trial. 61
30284350 2019
29
The Description of Urodynamic Study for Bladder Dysfunction in Compressive Myelo- or Radiculo-pathy: A Prospective Study in an Institutional Setup. 61
31497109 2019
30
Time-Dependent Changes of Urethral Function in Diabetes Mellitus: A Review. 61
31260608 2019
31
Anti-Nogo-A Antibodies As a Potential Causal Therapy for Lower Urinary Tract Dysfunction after Spinal Cord Injury. 61
30902870 2019
32
Urine retention in cattle putatively associated with injection of an ivermectin and closantel anthelmintic formulation into the ischiorectal fossa. 61
30742780 2019
33
A Review of Botulinum Toxin A for the Treatment of Neurogenic Bladder. 61
30138720 2019
34
Bladder Neuromodulation in Acute Spinal Cord Injury via Transcutaneous Tibial Nerve Stimulation: Cystometrogram and Autonomic Nervous System Evidence From a Randomized Control Pilot Trial. 61
30837835 2019
35
Impact of bowel management in alleviating symptoms of urinary incontinence in patients with spina bifida associated with overactive bladder and detrusor sphincter dyssynergia. 61
29802783 2019
36
Nocturia in Patients With Multiple Sclerosis. 61
31768133 2019
37
Rationales for a Urodynamic Study in Patients with Cervical Spondylotic Myelopathy. 61
30583129 2018
38
Urethral Pressure Measurement as a Tool for the Urodynamic Diagnosis of Detrusor Sphincter Dyssynergia. 61
30599498 2018
39
The maximum detrusor pressure as a predictive factor of success after sphincterotomy in detrusor-sphincter dyssynergia. 61
30203509 2018
40
Long-term urodynamic follow-up after external sphincterotomy in patients with spinal cord injury. 61
29717510 2018
41
Targeting p75 neurotrophin receptors ameliorates spinal cord injury-induced detrusor sphincter dyssynergia in mice. 61
29806700 2018
42
A Proof-of-Concept Study of Transcutaneous Magnetic Spinal Cord Stimulation for Neurogenic Bladder. 61
30135433 2018
43
Detrusor Acontractility after Acute Spinal Cord Injury-Myth or Reality? 61
29352989 2018
44
Novel Applications of OnabotulinumtoxinA in Lower Urinary Tract Dysfunction. 61
29949878 2018
45
Age-associated urethral dysfunction in urethane-anesthetized rats. 61
29333618 2018
46
ICS Educational Module: Electromyography in the assessment and therapy of lower urinary tract dysfunction in adults. 61
28419532 2018
47
Preserved Adrenal Function After Lumbar Spinal Cord Transection Augments Low Pressure Bladder Activity in the Rat. 61
30233411 2018
48
Botulinum Toxin Use in Neurourology. 61
30288145 2018
49
Lower Urinary Tract Function in Familial Spastic Paraplegia. 61
30391939 2018
50
Urinary Disorders and Marfan Syndrome: A Series of 4 Cases. 61
29176310 2018
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Variations for Detrusor Sphincter Dyssynergia

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Expression for Detrusor Sphincter Dyssynergia

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Search GEO for disease gene expression data for Detrusor Sphincter Dyssynergia.
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Pathways for Detrusor Sphincter Dyssynergia

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Pathways related to Detrusor Sphincter Dyssynergia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Peptide ligand-binding receptors 65
Show member pathways
 13.04 TRPV1 TAC1 P2RX3 P2RX2 HTR1A CALCA
2
Calcium signaling pathway 36
11.94 P2RX3 P2RX2 NGF ADRA1A
3
Neuroscience 4
11.89 SV2A SNAP25 NGF HTR1A CALCA
4
Taste transduction 36
Show member pathways
 11.64 P2RX3 P2RX2 HTR1A
5
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.23 TAC1 SNAP25 NGF HTR1A ADCYAP1
6
Endothelin Pathways 1
10.96 CALCA ADRA1A
7
Trk receptor signaling mediated by PI3K and PLC-gamma 1
10.91 TRPV1 NGF
8
Activation of TRKA receptors 65
Show member pathways
 10.36 NGF ADCYAP1
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GO Terms for Detrusor Sphincter Dyssynergia

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Cellular components related to Detrusor Sphincter Dyssynergia according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.8 TRPV1 SV2A NGF HTR1A
2 synapse GO:0045202 9.8 TRPV1 TAC1 SV2A SNAP25 PCLO P2RX2
3 glutamatergic synapse GO:0098978 9.71 SV2A SNAP25 PCLO ADRA1A
4 synaptic vesicle GO:0008021 9.65 SV2A SNAP25 NGF
5 postsynapse GO:0098794 9.63 SNAP25 P2RX3 P2RX2
6 neuron projection GO:0043005 9.63 TRPV1 SV2A SNAP25 P2RX3 CALCA ADCYAP1
7 GABA-ergic synapse GO:0098982 9.54 SV2A PCLO ADRA1A
8 terminal bouton GO:0043195 9.5 P2RX3 CALCA ADCYAP1
9 integral component of nuclear inner membrane GO:0005639 9.43 P2RX3 P2RX2
10 axon GO:0030424 9.43 TAC1 SNAP25 PCLO P2RX3 NGF CALCA
11 neuronal cell body GO:0043025 9.1 TRPV1 TAC1 SV2A P2RX3 P2RX2 CALCA

Biological processes related to Detrusor Sphincter Dyssynergia according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 10.06 TAC1 HTR1A CALCA ADRA1A ADCYAP1
2 cell-cell signaling GO:0007267 9.8 TAC1 CALCA ADRA1A ADCYAP1
3 neuropeptide signaling pathway GO:0007218 9.73 TAC1 CALCA ADCYAP1
4 cAMP-mediated signaling GO:0019933 9.65 PCLO ADCYAP1
5 insulin secretion GO:0030073 9.65 PCLO ADCYAP1
6 associative learning GO:0008306 9.65 TAC1 SNAP25
7 excitatory postsynaptic potential GO:0060079 9.65 TRPV1 P2RX3 P2RX2
8 glutamate secretion GO:0014047 9.64 TRPV1 SNAP25
9 behavioral fear response GO:0001662 9.64 HTR1A ADCYAP1
10 synaptic vesicle exocytosis GO:0016079 9.63 SNAP25 PCLO
11 neuromuscular synaptic transmission GO:0007274 9.63 P2RX3 P2RX2
12 regulation of vasoconstriction GO:0019229 9.62 HTR1A ADRA1A
13 positive regulation of blood vessel diameter GO:0097755 9.62 CALCA ADCYAP1
14 response to ATP GO:0033198 9.61 P2RX3 P2RX2
15 cellular response to ATP GO:0071318 9.61 TRPV1 P2RX3
16 sensory perception of pain GO:0019233 9.61 TRPV1 TAC1 ADCYAP1
17 detection of temperature stimulus involved in sensory perception of pain GO:0050965 9.6 TRPV1 CALCA
18 positive regulation of calcium-mediated signaling GO:0050850 9.59 P2RX3 P2RX2
19 synaptic vesicle priming GO:0016082 9.58 SV2A SNAP25
20 positive regulation of calcium ion transport into cytosol GO:0010524 9.58 P2RX3 P2RX2
21 response to heat GO:0009408 9.58 TRPV1 P2RX3 CALCA
22 response to carbohydrate GO:0009743 9.57 P2RX3 P2RX2
23 positive regulation of synaptic transmission, GABAergic GO:0032230 9.55 TAC1 ADRA1A
24 positive regulation of cytosolic calcium ion concentration GO:0007204 9.55 TRPV1 TAC1 CALCA ADRA1A ADCYAP1
25 negative regulation of heart rate GO:0010459 9.54 TRPV1 TAC1
26 cellular response to nerve growth factor stimulus GO:1990090 9.54 TRPV1 TAC1 CALCA
27 peristalsis GO:0030432 9.52 P2RX3 P2RX2
28 purinergic nucleotide receptor signaling pathway GO:0035590 9.51 P2RX3 P2RX2
29 response to pain GO:0048265 9.5 TRPV1 TAC1 CALCA
30 positive regulation of action potential GO:0045760 9.46 TAC1 ADRA1A
31 behavioral response to pain GO:0048266 9.43 TRPV1 P2RX3 P2RX2
32 urinary bladder smooth muscle contraction GO:0014832 9.13 TRPV1 P2RX3 P2RX2
33 chemical synaptic transmission GO:0007268 9.1 TAC1 SV2A SNAP25 P2RX3 P2RX2 HTR1A

Molecular functions related to Detrusor Sphincter Dyssynergia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion channel activity GO:0005216 9.33 TRPV1 P2RX3 P2RX2
2 ligand-gated ion channel activity GO:0015276 9.26 TRPV1 P2RX2
3 extracellularly ATP-gated cation channel activity GO:0004931 8.96 P2RX3 P2RX2
4 purinergic nucleotide receptor activity GO:0001614 8.62 P2RX3 P2RX2
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Sources for Detrusor Sphincter Dyssynergia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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