Aliases & Classifications for Detrusor Sphincter Dyssynergia

MalaCards integrated aliases for Detrusor Sphincter Dyssynergia:

Name: Detrusor Sphincter Dyssynergia 12 15
Detrusor and Sphincter Dyssynergia 73

External Ids:

Disease Ontology 12 DOID:12145
ICD9CM 35 596.55
UMLS 73 C0341747

Summaries for Detrusor Sphincter Dyssynergia

MalaCards based summary : Detrusor Sphincter Dyssynergia, also known as detrusor and sphincter dyssynergia, is related to spinal cord injury and neural tube defects, and has symptoms including dysuria and urgency of micturition. An important gene associated with Detrusor Sphincter Dyssynergia is RPS24 (Ribosomal Protein S24). The drugs Darifenacin and Muscarinic Antagonists have been mentioned in the context of this disorder. Affiliated tissues include spinal cord.

Related Diseases for Detrusor Sphincter Dyssynergia

Diseases related to Detrusor Sphincter Dyssynergia via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 spinal cord injury 11.0
2 neural tube defects 10.4
3 spinal cord disease 10.4
4 herpes simplex 10.4
5 multiple sclerosis 10.3
6 multiple system atrophy 1 10.3
7 hydronephrosis 10.3
8 neurogenic bladder 10.3
9 hinman syndrome 10.3

Comorbidity relations with Detrusor Sphincter Dyssynergia via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Detrusor Sphincter Dyssynergia:



Diseases related to Detrusor Sphincter Dyssynergia

Symptoms & Phenotypes for Detrusor Sphincter Dyssynergia

UMLS symptoms related to Detrusor Sphincter Dyssynergia:


dysuria, urgency of micturition

Drugs & Therapeutics for Detrusor Sphincter Dyssynergia

Drugs for Detrusor Sphincter Dyssynergia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Darifenacin Approved, Investigational Phase 2 133099-04-4 444031
2 Muscarinic Antagonists Phase 2
3 Cholinergic Antagonists Phase 2
4 Neurotransmitter Agents Phase 2
5 Cholinergic Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clinical Interest of the Temporary Urethral Stent Allium " Bulbar Urethral Stent " in the Treatment of Detrusor Sphincter Dyssynergia Completed NCT02323243 Phase 1, Phase 2
2 Study of Darifenacin in Patients Suffering From Multiple Sclerosis and Neurogenic Detrusor Overactivity Terminated NCT00845338 Phase 2 Darifenacin (BAY79-4998)
3 Neuro-urological Outcome After Spinal Cord Injury Completed NCT01297660
4 Transcutaneous Tibial Nerve Stimulation for Treating Neurogenic Lower Urinary Tract Dysfunction Recruiting NCT02859844 Not Applicable

Search NIH Clinical Center for Detrusor Sphincter Dyssynergia

Genetic Tests for Detrusor Sphincter Dyssynergia

Anatomical Context for Detrusor Sphincter Dyssynergia

MalaCards organs/tissues related to Detrusor Sphincter Dyssynergia:

41
Spinal Cord

Publications for Detrusor Sphincter Dyssynergia

Articles related to Detrusor Sphincter Dyssynergia:

(show top 50) (show all 83)
# Title Authors Year
1
The Impact of Bowel Management in Alleviating Symptoms of Urinary Incontinence in Spina Bifida Patients with Overactive Bladder and Detrusor Sphincter Dyssynergia. ( 29802783 )
2018
2
Targeting p75 neurotrophin receptors ameliorates spinal cord injury-induced detrusor sphincter dyssynergia in mice. ( 29806700 )
2018
3
The maximum detrusor pressure as a predictive factor of success after sphincterotomy in detrusor-sphincter dyssynergia. ( 30203509 )
2018
4
Effects of botulinum toxin A injections in spinal cord injury patients with detrusor overactivity and detrusor sphincter dyssynergia. ( 27563834 )
2016
5
Improvement in detrusor-sphincter dyssynergia by bladder-wall injection of replication-defective herpes simplex virus vector-mediated gene delivery of kynurenine aminotransferase II in spinal cord injury rats. ( 27995942 )
2016
6
Predictors of outcome for urethral injection of botulinum toxin to treat detrusor sphincter dyssynergia in men with spinal cord injury. ( 27256824 )
2016
7
Detrusor sphincter dyssynergia: a review of physiology, diagnosis, and treatment strategies. ( 26904418 )
2016
8
Quick note on tissue engineering-based surgical measures to treat patients with neurogenic bladder-due detrusor/sphincter dyssynergia. ( 26042661 )
2015
9
Predictors of outcome for urethral injection of botulinum toxin to treat detrusor sphincter dyssynergia in men with spinal cord injury. ( 26712037 )
2015
10
Long-term outcome of intravesical oxybutynin in children with detrusor-sphincter dyssynergia: with special reference to age-dependent parameters. ( 24436114 )
2015
11
Therapeutic outcome and quality of life between urethral and detrusor botulinum toxin treatment for patients with spinal cord lesions and detrusor sphincter dyssynergia. ( 24073977 )
2013
12
Diagnosing detrusor sphincter dyssynergia in the neurological patient. ( 22458490 )
2012
13
Do Sacral/Peripheral Lesions Contribute to Detrusor-Sphincter Dyssynergia? ( 26676618 )
2012
14
Therapeutic effects of detrusor botulinum toxin A injection on neurogenic detrusor overactivity in patients with different levels of spinal cord injury and types of detrusor sphincter dyssynergia. ( 21243000 )
2011
15
Suppression of detrusor-sphincter dyssynergia by herpes simplex virus vector mediated gene delivery of glutamic acid decarboxylase in spinal cord injured rats. ( 20663524 )
2010
16
Olfactory mucosal transplantation after spinal cord injury improves voiding efficiency by suppressing detrusor-sphincter dyssynergia in rats. ( 20639055 )
2010
17
Urodynamic analysis in multiple system atrophy: characterisation of detrusor-sphincter dyssynergia. ( 20683607 )
2010
18
Transperineal injection of botulinum toxin A for treatment of detrusor sphincter dyssynergia: localization with combined fluoroscopic and electromyographic guidance. ( 19406304 )
2009
19
Therapeutic satisfaction and dissatisfaction in patients with spinal cord lesions and detrusor sphincter dyssynergia who received detrusor botulinum toxin a injection. ( 18533231 )
2008
20
Urodynamic responses to anal stretch in patients with detrusor sphincter dyssynergia. ( 18760159 )
2008
21
Outcome after treatment of detrusor-sphincter dyssynergia by temporary stent. ( 17471293 )
2008
22
Satisfaction with urethral injection of botulinum toxin A for detrusor sphincter dyssynergia in patients with spinal cord lesion. ( 18508331 )
2008
23
Long-term follow-up study of intraurethral stents in spinal cord injured patients with detrusor-sphincter dyssynergia. ( 17211463 )
2007
24
Memokath stents for the treatment of detrusor sphincter dyssynergia (DSD) in men with spinal cord injury: the Princess Royal Spinal Injuries Unit 10-year experience. ( 16520816 )
2007
25
Treatment of detrusor sphincter dyssynergia with baclofen and doxazosin. ( 17124622 )
2006
26
Memokath stents for the treatment of detrusor sphincter dyssynergia (DSD) in men with spinal cord injury: the Princess Royal Spinal Injuries Unit 10-year experience. ( 16044169 )
2006
27
Detrusor-sphincter dyssynergia. ( 17169006 )
2006
28
Placebo controlled, randomised, double blind study of the effects of botulinum A toxin on detrusor sphincter dyssynergia in multiple sclerosis patients. ( 16291892 )
2005
29
Understanding detrusor sphincter dyssynergia--significance of chronology. ( 16230135 )
2005
30
Can neurologic examination predict type of detrusor sphincter-dyssynergia in patients with spinal cord injury? ( 15708030 )
2005
31
Urethral stents for detrusor sphincter dyssynergia. ( 15679792 )
2005
32
Suppression of detrusor-sphincter dyssynergia by immunoneutralization of nerve growth factor in lumbosacral spinal cord in spinal cord injured rats. ( 14665959 )
2004
33
Oral nitric oxide donors: a new pharmacological approach to detrusor-sphincter dyssynergia in spinal cord injured patients? ( 15041118 )
2004
34
Urethral stent for the treatment of detrusor-sphincter dyssynergia: evaluation of the clinical, urodynamic, endoscopic and radiological efficacy after more than 1 year. ( 15247742 )
2004
35
The use of the Memokath stent in the treatment of detrusor sphincter dyssynergia in spinal cord injury patients: a single-centre seven-year experience. ( 12706000 )
2003
36
Sphincterotomy and the treatment of detrusor-sphincter dyssynergia: current status, future prospects. ( 12494314 )
2003
37
Botulinum a toxin and detrusor sphincter dyssynergia: a double-blind lidocaine-controlled study in 13 patients with spinal cord disease. ( 12121731 )
2002
38
Treatment of detrusor-sphincter dyssynergia by pudendal nerve block in patients with spinal cord injury. ( 11994813 )
2002
39
A modified biofeedback program for children with detrusor-sphincter dyssynergia: 5-year experience. ( 11547115 )
2001
40
Biofeedback successfully cures detrusor-sphincter dyssynergia in pediatric patients. ( 10799231 )
2000
41
Removal of UroLume endoprosthesis: experience of the North American Study Group for detrusor-sphincter dyssynergia application. ( 10687974 )
2000
42
Clinical significance of detrusor sphincter dyssynergia type in patients with post-traumatic spinal cord injury. ( 11018603 )
2000
43
Long-term followup of the North American multicenter UroLume trial for the treatment of external detrusor-sphincter dyssynergia. ( 10210393 )
1999
44
Detrusor-sphincter dyssynergia and vesico urethral reflux: management. ( 9471129 )
1998
45
Botulinum A toxin treatment for detrusor-sphincter dyssynergia in spinal cord disease. ( 9494997 )
1998
46
Use of the Memokath for detrusor-sphincter dyssynergia after spinal cord injury--a cautionary tale. ( 9471137 )
1998
47
Treatment of detrusor sphincter dyssynergia by transperineal injection of botulinum toxin. ( 9630155 )
1998
48
Bladder leak point pressure: the measure for sphincterotomy success in spinal cord injured patients with external detrusor-sphincter dyssynergia. ( 9649270 )
1998
49
Pediatric case of the day. Hinman syndrome (nonneurogenic bladder [NNNB], detrusor-sphincter dyssynergia). ( 9460133 )
1998
50
Botulinum A toxin as a treatment of detrusor-sphincter dyssynergia in patients with spinal cord injury: MRI controlled transperineal injections. ( 9343126 )
1997

Variations for Detrusor Sphincter Dyssynergia

Expression for Detrusor Sphincter Dyssynergia

Search GEO for disease gene expression data for Detrusor Sphincter Dyssynergia.

Pathways for Detrusor Sphincter Dyssynergia

GO Terms for Detrusor Sphincter Dyssynergia

Sources for Detrusor Sphincter Dyssynergia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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