MCID: DVL001
MIFTS: 38

Developmental Coordination Disorder

Categories: Mental diseases, Neuronal diseases

Aliases & Classifications for Developmental Coordination Disorder

MalaCards integrated aliases for Developmental Coordination Disorder:

Name: Developmental Coordination Disorder 12 77 15 74
Motor Skills Disorders 45 74

Classifications:



External Ids:

Disease Ontology 12 DOID:9923
ICD9CM 36 315.4
MeSH 45 D019957
NCIt 51 C92561
SNOMED-CT 69 27544004
ICD10 34 F82

Summaries for Developmental Coordination Disorder

Disease Ontology : 12 A specific developmental disorder that involves disordered motor skills where coordinated muscle movement is impaired.

MalaCards based summary : Developmental Coordination Disorder, also known as motor skills disorders, is related to developmental dyspraxia and dysgraphia, and has symptoms including ataxia and clumsiness. An important gene associated with Developmental Coordination Disorder is RBFOX1 (RNA Binding Fox-1 Homolog 1). The drugs Dopamine and Methylphenidate have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and eye, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 77 Developmental coordination disorder (DCD), also known as developmental motor coordination disorder,... more...

Related Diseases for Developmental Coordination Disorder

Graphical network of the top 20 diseases related to Developmental Coordination Disorder:



Diseases related to Developmental Coordination Disorder

Symptoms & Phenotypes for Developmental Coordination Disorder

UMLS symptoms related to Developmental Coordination Disorder:


ataxia, clumsiness

GenomeRNAi Phenotypes related to Developmental Coordination Disorder according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-101 9.36 ELP4 GAP43
2 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.36 GAP43
3 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.36 ELP4
4 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.36 ELP4
5 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.36 GAP43
6 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.36 GAP43
7 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.36 ELP4
8 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.36 ELP4
9 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.36 GAP43
10 Increased shRNA abundance (Z-score > 2) GR00366-A-6 9.36 ELP4

Drugs & Therapeutics for Developmental Coordination Disorder

Drugs for Developmental Coordination Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 53)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 3,Phase 2 62-31-7, 51-61-6 681
2
Methylphenidate Approved, Investigational Phase 4,Not Applicable 113-45-1 4158
3 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
4 Dopamine Agents Phase 4,Phase 3,Phase 2
5 Dopamine Uptake Inhibitors Phase 4
6 Central Nervous System Stimulants Phase 4,Not Applicable
7 Neurotransmitter Uptake Inhibitors Phase 4
8
Carbidopa Approved Phase 3 28860-95-9 34359
9
Levodopa Approved Phase 3,Phase 2 59-92-7 6047
10
Droxidopa Approved, Investigational Phase 3 23651-95-8 443940
11
Entacapone Approved, Investigational Phase 3 130929-57-6 5281081
12
Tramiprosate Investigational Phase 3 3687-18-1
13
Xaliproden Investigational Phase 3 135354-02-8, 428863-50-7 128919
14 GABA Agonists Phase 3
15 GABA Agents Phase 3
16 Anticonvulsants Phase 3
17 Omega 3 Fatty Acid Phase 3
18 Olive Phase 3
19 Serotonin 5-HT1 Receptor Agonists Phase 3
20 Serotonin Agents Phase 3
21 Serotonin Receptor Agonists Phase 3
22 Antiparkinson Agents Phase 3,Phase 2
23 Aromatic Amino Acid Decarboxylase Inhibitors Phase 3
24 Adjuvants, Immunologic Phase 3
25 Carbidopa, levodopa drug combination Phase 3
26 Immunologic Factors Phase 3,Phase 1,Phase 2
27 Dopamine agonists Phase 3
28 Cardiotonic Agents Phase 3
29 Peripheral Nervous System Agents Phase 3
30 Protective Agents Phase 3
31 Autonomic Agents Phase 3
32 Sympathomimetics Phase 3
33 Catechol Phase 3
34 Catechol O-Methyltransferase Inhibitors Phase 3
35
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
36
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 46835353 5284616 6436030
37
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
38
Everolimus Approved Phase 1, Phase 2 159351-69-6 70789204 6442177
39 Dihydroxyphenylalanine Phase 2
40 Anti-Bacterial Agents Phase 1, Phase 2
41 Anti-Infective Agents Phase 1, Phase 2
42 Immunosuppressive Agents Phase 1, Phase 2
43 Antifungal Agents Phase 1, Phase 2
44 Antibiotics, Antitubercular Phase 1, Phase 2
45 Hops Approved Not Applicable
46
Pramipexole Approved, Investigational 104632-26-0 119570 59868
47
Uric acid Investigational Not Applicable 69-93-2 1175
48 Pharmaceutical Solutions Not Applicable
49 Antioxidants
50 Adrenergic Agents

Interventional clinical trials:

(show top 50) (show all 54)
# Name Status NCT ID Phase Drugs
1 The Effect of Methylphenidate on Non-motor Symptoms and Postural Control in Parkinson's Disease. Terminated NCT01244269 Phase 4 Methylphenidate;Methylphenidate;Placebo 10;Placebo 20
2 Evaluation of 3APS in Patients With Mild to Moderate Alzheimer’s Disease Unknown status NCT00088673 Phase 3 3APS
3 Omega-3/Omega-6 Fatty Acids for Attention-Deficit/Hyperactivity Disorder (ADHD): A Trial in Children and Adolescents Completed NCT01219309 Phase 3
4 18-Month Study of the Efficacy of Xaliproden (SR57746A) in Patients With Mild-to-Moderate Dementia of the Alzheimer's Type Completed NCT00103649 Phase 3 xaliproden (SR57746A)
5 An Open Label Extension Study of the Safety and Clinical Utility of IPX066 in Subjects With Parkinson's Disease Completed NCT01096186 Phase 3 IPX066 95 mg;IPX066 145 mg;IPX066 195 mg;IPX066 245 mg
6 Open-Label Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH) Completed NCT00738062 Phase 3 Droxidopa;Placebo
7 Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH) Completed NCT00633880 Phase 3 Placebo;Droxidopa
8 Efficacy, Safety, and Tolerability of E2007 in Levodopa Treated Parkinson's Disease Patients With Motor Fluctuations Completed NCT00368108 Phase 3 2 mg perampanel;4 mg perampanel;placebo comparator
9 A Study to Evaluate Fixed Dose Carbidopa/Levodopa/Entacapone Versus Immediate Release Carbidopa/Levodopa Completed NCT00134966 Phase 3 capsules containing: carbidopa (25 mg), levodopa (100 mg), entacapone (200 mg)
10 Safinamide in Levodopa Induced Dyskinesia in Parkinson's Disease Subjects Completed NCT01113320 Phase 2 Placebo;Safinamide
11 A Fourteen-Week Placebo-Controlled Dose-Response Efficacy and Safety Study of NS 2330 in Early Parkinson's Disease Patients (Study for Proof of Concept in Early Parkinson's Disease of a Triple Reuptake Inhibitor, NS 2330 / SCEPTRE) Completed NCT00148486 Phase 2 NS 2330
12 Evaluation of the Efficacy and Safety of AFQ056 in Reducing Moderate to Severe L-dopa Induced Dyskinesias in Patients With Parkinson's Disease Completed NCT00986414 Phase 2 AFQ056;AFQ056;AFQ056;AFQ056;AFQ056;Placebo
13 RAD001 and Neurocognition in PTEN Hamartoma Tumor Syndrome Recruiting NCT02991807 Phase 1, Phase 2 RAD001;Placebo
14 Rehabilitating Corticospinal Control of Walking Active, not recruiting NCT02132650 Phase 2
15 Effects of Delayed Cord Clamping in Very Low Birth Weight Infants Completed NCT00840983 Phase 1
16 Mental Attention-neuromuscular Training for Children With Developmental Coordination Disorder Unknown status NCT02397161 Not Applicable
17 Functional Movement-power Training for Children With Developmental Coordination Disorder: A Randomised Controlled Trial Unknown status NCT02393404 Not Applicable
18 The Effect of Virtual Reality on Motor Functioning and Participation Abilities Among Children With DCD Unknown status NCT02504385 Not Applicable
19 Characterization of Executive Functions and Patterns of Eye Movements in Children With Developmental Disabilities Unknown status NCT00716235
20 The Effects of a Group-based Gaze Training Intervention for Children With Developmental Coordination Disorder Completed NCT02904980 Not Applicable
21 Efficacy of the CO-OP Approach With Brazilian Children With Developmental Coordination Disorder Completed NCT03112746 Not Applicable
22 Fitball Program Versus Task-oriented Motor Program on Improving Postural Control in Developmental Coordination Disorder Completed NCT01207544 Not Applicable
23 Functional MRI Study in Children With a Developmental Coordination Disorder (DCD) and/or Developmental Dyslexia (DD) Completed NCT02393729 Not Applicable
24 A Teleintervention in Developmental Coordination Disorder Completed NCT03141333 Not Applicable
25 Effects of CO-OP Approach on Activity and Participation of Brazilian Children With Developmental Coordination Disorder Completed NCT02893852 Not Applicable
26 Characteristic of Play: Comparison Between Children With Development Coordination Disorder ( DCD) and Children With Typical Development Completed NCT01130038
27 Developing and Evaluating a Meta-cognitive Intervention Amongst Adolescents With Neuro-development Disabilities Completed NCT03618563 Not Applicable
28 Helping Our Premature Infants ON to Better Motor Skills (HOP-ON) Completed NCT01281358 Not Applicable
29 The Role of Brain-derived Neurotropic Factor in the Relationship Between Executive Function and Physical Training Completed NCT02503579 Not Applicable
30 Differences in Muscle Activity Patterns and Graphical Product Quality in Children With Graphomotor Impairment Completed NCT02501590
31 Hippotherapy to Improve the Balance of Children With Movement Disorders Completed NCT01313325 Not Applicable
32 A Study of Neurophysiologically Based Occupational Therapy Intervention (NBOTI) for Feeding in the NCCU. Completed NCT00766051 Not Applicable
33 Profile of Newborn Undergoing Early Stimulation in a Neonatal Intensive Care Unit Completed NCT01660178
34 Cognitive and Motor Training in Pediatric Posterior Fossa Tumor Survivors Completed NCT03951246 Not Applicable
35 Impulse Control Disorders in Parkinson's Patients Treated With Pramipexole and Other Agents (DOMINION Study) Completed NCT00617019
36 Co Morbid Attention Deficit and Hyperactivity Disorder(ADHD) and Developmental Co Ordination Disorder (DCD) Recruiting NCT03595826 Not Applicable Neurostimulant pharmaceutical drugs
37 Effect of tDCS on Postural Control of Children With DCD Recruiting NCT03892083 Not Applicable
38 Development of Children With DCD Before the Age of Six Recruiting NCT03690843
39 Does tDCS Improve Motor Learning in Children With DCD? Recruiting NCT03453983 Not Applicable
40 Taekwondo for Children With Developmental Coordination Disorder Recruiting NCT02635711 Not Applicable
41 DCD Imaging-Intervention Study Recruiting NCT02597751 Not Applicable
42 Reliability and Validity of a Computerized Tool to Assess Proprioception and Motor Planning Among Children With Coordination Disorders Recruiting NCT03285776
43 Neurobehavioural Development of Infants Born <30 Weeks Gestational Age Between Birth and Five Years of Age Recruiting NCT03172104
44 Identification of Neuropsychological, Genetic and Neuroimaging Markers and Treatment Response Predictors of ADHD Recruiting NCT02430896 Methylphenidate (MPH);Atomoxetine
45 Tai Chi Training for Children With ADHD Recruiting NCT02234557 Not Applicable
46 tES With Random Noise Stimulation Applied to Children With Brain Injury Recruiting NCT02656433 Not Applicable
47 Rhythmic Motor Learning in Children With Developmental Coordination Disorders Active, not recruiting NCT03150784 Not Applicable
48 Taping for Children With and Without Movement Clumsiness Active, not recruiting NCT02945124 Not Applicable
49 Exploring the Impact and Feasibility of a Pathway to Sport and Long-term Participation in Young People Enrolling by invitation NCT02517333 Not Applicable
50 Evolution of Maternal Weight During Pregnancy and Influence on the Endothelial Function in Her Offspring Enrolling by invitation NCT02992106 Not Applicable

Search NIH Clinical Center for Developmental Coordination Disorder

Cochrane evidence based reviews: motor skills disorders

Genetic Tests for Developmental Coordination Disorder

Anatomical Context for Developmental Coordination Disorder

MalaCards organs/tissues related to Developmental Coordination Disorder:

42
Brain, Testes, Eye, Endothelial, Bone, Heart

Publications for Developmental Coordination Disorder

Articles related to Developmental Coordination Disorder:

(show top 50) (show all 688)
# Title Authors Year
1
Symptoms of anxiety and depression in children with developmental coordination disorder: a systematic review. ( 31029680 )
2019
2
A Review of Functional and Structural Neurobiology of the Action Observation Network in Autism Spectrum Disorder and Developmental Coordination Disorder. ( 30925819 )
2019
3
Children with Autism Spectrum Disorder, Developmental Coordination Disorder, and typical development differ in characteristics of dynamic postural control: A preliminary study. ( 30245240 )
2019
4
Nature of motor impairments in autism spectrum disorder: A comparison with developmental coordination disorder. ( 29923455 )
2019
5
Mirror neuron system activation in children with developmental coordination disorder: A replication functional MRI study. ( 29274848 )
2019
6
Age-related validity and reliability of the Dutch Little Developmental Coordination Disorder Questionnaire (LDCDQ-NL). ( 29477487 )
2019
7
Does the Movement Assessment Battery for Children-2 at 3 years of age predict developmental coordination disorder at 4.5 years of age in children born very preterm? ( 29653831 )
2019
8
Health-related quality of life of children with Developmental Coordination Disorder. ( 29907374 )
2019
9
Physiological characteristics, self-perceptions, and parental support of physical activity in children with, or at risk of, developmental coordination disorder. ( 29914720 )
2019
10
Participation of children with developmental coordination disorder. ( 30041931 )
2019
11
Y-Balance Test Performance and Leg Muscle Activations of Children with Developmental Coordination Disorder. ( 30095371 )
2019
12
Suboptimal bone status for adolescents with low motor competence and developmental coordination disorder-It's sex specific. ( 30119956 )
2019
13
Is virtual reality effective in improving the motor performance of children with developmental coordination disorder? A systematic review. ( 30311491 )
2019
14
Cross-Cultural Adaptation of the Developmental Coordination Disorder Questionnaire in Turkish Children. ( 30428280 )
2019
15
Assessing the potential of the qualitative trajectory calculus to detect gait pathologies: a case study of children with developmental coordination disorder. ( 30449157 )
2019
16
Research Review: Internalising symptoms in developmental coordination disorder: a systematic review and meta-analysis. ( 30485419 )
2019
17
Developmental coordination disorder: the impact on the family. ( 30536221 )
2019
18
Effect of Kinesio taping on Y-balance test performance and the associated leg muscle activation patterns in children with developmental coordination disorder: A randomized controlled trial. ( 30590353 )
2019
19
Do video game interventions improve motor outcomes in children with developmental coordination disorder? A systematic review using the ICF framework. ( 30651097 )
2019
20
Prevalence of suspected developmental coordination disorder and associated factors in Spanish classrooms. ( 30654220 )
2019
21
International clinical practice recommendations on the definition, diagnosis, assessment, intervention, and psychosocial aspects of developmental coordination disorder. ( 30671947 )
2019
22
Risk of Developmental Coordination Disorder in Italian very preterm children at school age compared to general population controls. ( 30711366 )
2019
23
Effect of Kinesio taping on electromyographic activity of leg muscles during gait in children with developmental coordination disorder: A randomized controlled trial. ( 30732198 )
2019
24
Developmental coordination disorder continues to evolve. ( 30734941 )
2019
25
Gaze training supports self-organization of movement coordination in children with developmental coordination disorder. ( 30737438 )
2019
26
Haptic perception is altered in children with developmental coordination disorder. ( 30738812 )
2019
27
The Impact of Equine Therapy and an Audio-Visual Approach Emphasizing Rhythm and Beat Perception in Children with Developmental Coordination Disorder. ( 30789282 )
2019
28
Is Wii-based motor training better than task-specific matched training for children with developmental coordination disorder? A randomized controlled trial. ( 30794762 )
2019
29
Finger soaking enhances effects of light touch on reducing body sway in children with developmental coordination disorder. ( 30815705 )
2019
30
External focus of attention concurrently elicits optimal performance of suprapostural pole-holding task and postural stability in children with developmental coordination disorder. ( 30872044 )
2019
31
A school-based physical activity intervention for children with developmental coordination disorder: A randomized controlled trial. ( 30875607 )
2019
32
Very preterm children at risk for developmental coordination disorder have brain alterations in motor areas. ( 30891804 )
2019
33
Motor imagery during action observation enhances automatic imitation in children with and without developmental coordination disorder. ( 30921604 )
2019
34
Movement Control Strategies in a Dynamic Balance Task in Children With and Without Developmental Coordination Disorder. ( 30961441 )
2019
35
Physical activity in young children at risk for developmental coordination disorder. ( 30963540 )
2019
36
Adults with probable developmental coordination disorder selectively process early visual, but not tactile information during action preparation. An electrophysiological study. ( 30981450 )
2019
37
Automated Fine Motor Evaluation for Developmental Coordination Disorder. ( 30998471 )
2019
38
Hypermobility, developmental coordination disorder and physical activity in an Irish paediatric population. ( 31062457 )
2019
39
Diagnostic challenge and importance of the clinical approach of the Developmental Coordination Disorder. ( 31063311 )
2019
40
Is developmental coordination disorder in preterm children the motor phenotype of more widespread brain pathology? ( 31106450 )
2019
41
Efficacy of the cognitive orientation to daily occupational performance with Brazilian children with developmental coordination disorder. ( 29260603 )
2019
42
Quality of life and psychosocial functioning in adolescents with developmental coordination disorder and attention-deficit-hyperactivity disorder. ( 29727010 )
2018
43
Health-related quality of life and peer relationships in adolescents with developmental coordination disorder and attention-deficit-hyperactivity disorder. ( 29611868 )
2018
44
Functional brain correlates of motor response inhibition in children with developmental coordination disorder and attention deficit/hyperactivity disorder. ( 29655169 )
2018
45
Behavioral Own-Body-Transformations in Children and Adolescents With Typical Development, Autism Spectrum Disorder, and Developmental Coordination Disorder. ( 29887813 )
2018
46
Comparing Attention to Socially-Relevant Stimuli in Autism Spectrum Disorder and Developmental Coordination Disorder. ( 29313185 )
2018
47
Leg muscle activation patterns during walking and leg lean mass are different in children with and without developmental coordination disorder. ( 29275080 )
2018
48
Diversity of activity participation determines bone mineral content in the lower limbs of pre-pubertal children with developmental coordination disorder. ( 29285628 )
2018
49
The brains of children with developmental coordination disorder. ( 29298759 )
2018
50
Motor Skill Interventions in Children With Developmental Coordination Disorder: A Systematic Review and Meta-Analysis. ( 29329670 )
2018

Variations for Developmental Coordination Disorder

Expression for Developmental Coordination Disorder

Search GEO for disease gene expression data for Developmental Coordination Disorder.

Pathways for Developmental Coordination Disorder

GO Terms for Developmental Coordination Disorder

Molecular functions related to Developmental Coordination Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lyase activity GO:0016829 8.62 FTCD PTS

Sources for Developmental Coordination Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
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45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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