MCID: DVL001
MIFTS: 37

Developmental Coordination Disorder

Categories: Mental diseases, Neuronal diseases

Aliases & Classifications for Developmental Coordination Disorder

MalaCards integrated aliases for Developmental Coordination Disorder:

Name: Developmental Coordination Disorder 12 76 15 73
Motor Skills Disorders 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:9923
ICD10 33 F82
ICD9CM 35 315.4
MeSH 44 D019957
NCIt 50 C92561
SNOMED-CT 68 27544004

Summaries for Developmental Coordination Disorder

Disease Ontology : 12 A specific developmental disorder that involves disordered motor skills where coordinated muscle movement is impaired.

MalaCards based summary : Developmental Coordination Disorder, also known as motor skills disorders, is related to developmental dyspraxia and dysgraphia, and has symptoms including ataxia and clumsiness. An important gene associated with Developmental Coordination Disorder is RBFOX1 (RNA Binding Fox-1 Homolog 1). The drugs Omega 3 Fatty Acid and Olive have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and eye, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Developmental coordination disorder (DCD), also known as developmental dyspraxia or simply dyspraxia, is... more...

Related Diseases for Developmental Coordination Disorder

Diseases related to Developmental Coordination Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 24)
# Related Disease Score Top Affiliating Genes
1 developmental dyspraxia 11.9
2 dysgraphia 11.2
3 attention deficit-hyperactivity disorder 10.5
4 autism 10.4
5 autism spectrum disorder 10.3
6 dysphasia, familial developmental 10.2
7 specific language impairment 10.2
8 dyslexia 10.2
9 learning disability 10.2
10 oculocerebral syndrome with hypopigmentation 10.0
11 cerebral palsy 10.0
12 niemann-pick disease 10.0
13 epilepsy 10.0
14 schizophrenia 9.9
15 ataxia and polyneuropathy, adult-onset 9.9
16 anxiety 9.9
17 spastic hemiplegia 9.9
18 hemiplegia 9.9
19 hypermobility syndrome 9.9
20 vascular disease 9.9
21 infertility 9.9
22 hypermobile ehlers-danlos syndrome 9.9
23 hypotonia 9.9
24 benign epilepsy with centrotemporal spikes 9.8 ELP4 RBFOX1

Graphical network of the top 20 diseases related to Developmental Coordination Disorder:



Diseases related to Developmental Coordination Disorder

Symptoms & Phenotypes for Developmental Coordination Disorder

UMLS symptoms related to Developmental Coordination Disorder:


ataxia, clumsiness

GenomeRNAi Phenotypes related to Developmental Coordination Disorder according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-101 9.36 ELP4 GAP43
2 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.36 GAP43
3 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.36 ELP4
4 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.36 ELP4
5 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.36 GAP43
6 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.36 GAP43
7 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.36 ELP4
8 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.36 ELP4
9 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.36 GAP43
10 Increased shRNA abundance (Z-score > 2) GR00366-A-6 9.36 ELP4

Drugs & Therapeutics for Developmental Coordination Disorder

Drugs for Developmental Coordination Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Omega 3 Fatty Acid Phase 3
2 Olive Phase 3
3
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
4
Everolimus Approved Phase 1, Phase 2 159351-69-6 6442177
5
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 46835353 6436030 5284616
6 Antibiotics, Antitubercular Phase 1, Phase 2
7 Immunologic Factors Phase 1, Phase 2
8 Anti-Bacterial Agents Phase 1, Phase 2
9 Anti-Infective Agents Phase 1, Phase 2
10 Immunosuppressive Agents Phase 1, Phase 2
11 Antifungal Agents Phase 1, Phase 2
12 Hops Approved Not Applicable
13
Methylphenidate Approved, Investigational Not Applicable 113-45-1 4158
14
Dopamine Approved 51-61-6, 62-31-7 681
15
Uric Acid Experimental, Investigational Not Applicable 69-93-2 1175
16 Neurotransmitter Agents
17 Neurotransmitter Uptake Inhibitors
18 Adrenergic Agents
19 Dopamine Uptake Inhibitors
20 Central Nervous System Stimulants ,Not Applicable
21 Atomoxetine Hydrochloride
22 Dopamine Agents
23 Pharmaceutical Solutions Not Applicable
24 Insulin, Globin Zinc Not Applicable
25 insulin Not Applicable

Interventional clinical trials:

(show all 33)
# Name Status NCT ID Phase Drugs
1 Omega-3/Omega-6 Fatty Acids for Attention-Deficit/Hyperactivity Disorder (ADHD): A Trial in Children and Adolescents Completed NCT01219309 Phase 3
2 RAD001 and Neurocognition in PTEN Hamartoma Tumor Syndrome Recruiting NCT02991807 Phase 1, Phase 2 RAD001;Placebo
3 Mental Attention-neuromuscular Training for Children With Developmental Coordination Disorder Unknown status NCT02397161 Not Applicable
4 Functional Movement-power Training for Children With Developmental Coordination Disorder: A Randomised Controlled Trial Unknown status NCT02393404 Not Applicable
5 The Effect of Virtual Reality on Motor Functioning and Participation Abilities Among Children With DCD Unknown status NCT02504385 Not Applicable
6 Characterization of Executive Functions and Patterns of Eye Movements in Children With Developmental Disabilities Unknown status NCT00716235
7 The Effects of a Group-based Gaze Training Intervention for Children With Developmental Coordination Disorder Completed NCT02904980 Not Applicable
8 Efficacy of the CO-OP Approach With Brazilian Children With Developmental Coordination Disorder Completed NCT03112746 Not Applicable
9 Fitball Program Versus Task-oriented Motor Program on Improving Postural Control in Developmental Coordination Disorder Completed NCT01207544 Not Applicable
10 Functional MRI Study in Children With a Developmental Coordination Disorder (DCD) and/or Developmental Dyslexia (DD) Completed NCT02393729 Not Applicable
11 A Teleintervention in Developmental Coordination Disorder Completed NCT03141333 Not Applicable
12 Characteristic of Play: Comparison Between Children With Development Coordination Disorder ( DCD) and Children With Typical Development Completed NCT01130038
13 Developing and Evaluating a Meta-cognitive Intervention Amongst Adolescents With Neuro-development Disabilities Completed NCT03618563 Not Applicable
14 Helping Our Premature Infants ON to Better Motor Skills (HOP-ON) Completed NCT01281358 Not Applicable
15 The Role of Brain-derived Neurotropic Factor in the Relationship Between Executive Function and Physical Training Completed NCT02503579 Not Applicable
16 Differences in Muscle Activity Patterns and Graphical Product Quality in Children With Graphomotor Impairment Copying and Tracing Activities on Horizontal or Vertical Surfaces Completed NCT02501590
17 Hippotherapy to Improve the Balance of Children With Movement Disorders Completed NCT01313325 Not Applicable
18 A Study of Neurophysiologically Based Occupational Therapy Intervention (NBOTI) for Feeding in the NCCU. Completed NCT00766051 Not Applicable
19 Co Morbid Attention Deficit and Hyperactivity Disorder(ADHD) and Developmental Co Ordination Disorder (DCD) Recruiting NCT03595826 Not Applicable Neurostimulant pharmaceutical drugs
20 Does tDCS Improve Motor Learning in Children With DCD? Recruiting NCT03453983 Not Applicable
21 Taekwondo for Children With Developmental Coordination Disorder Recruiting NCT02635711 Not Applicable
22 Development of Children With DCD Before the Age of Six Recruiting NCT03690843
23 DCD Imaging-Intervention Study Recruiting NCT02597751 Not Applicable
24 Reliability and Validity of a Computerized Tool to Assess Proprioception and Motor Planning Among Children With Coordination Disorders Recruiting NCT03285776
25 Neurobehavioural Development of Infants Born <30 Weeks Gestational Age Between Birth and Five Years of Age Recruiting NCT03172104
26 Identification of Neuropsychological, Genetic and Neuroimaging Markers and Treatment Response Predictors of ADHD Recruiting NCT02430896 Methylphenidate (MPH);Atomoxetine
27 Tai Chi Training for Children With ADHD Recruiting NCT02234557 Not Applicable
28 Rhythmic Motor Learning in Children With Developmental Coordination Disorders Active, not recruiting NCT03150784 Not Applicable
29 Taping for Children With and Without Movement Clumsiness Active, not recruiting NCT02945124 Not Applicable
30 Effects of CO-OP Approach on Activity and Participation of Brazilian Children With Developmental Coordination Disorder Active, not recruiting NCT02893852 Not Applicable
31 Exploring the Impact and Feasibility of a Pathway to Sport and Long-term Participation in Young People Enrolling by invitation NCT02517333 Not Applicable
32 Evolution of Maternal Weight During Pregnancy and Influence on the Endothelial Function in Her Offspring Enrolling by invitation NCT02992106 Not Applicable
33 Tai Chi-muscle Power Training for Primary School Children With Developmental Coordination Disorder Not yet recruiting NCT03598478 Not Applicable

Search NIH Clinical Center for Developmental Coordination Disorder

Cochrane evidence based reviews: motor skills disorders

Genetic Tests for Developmental Coordination Disorder

Anatomical Context for Developmental Coordination Disorder

MalaCards organs/tissues related to Developmental Coordination Disorder:

41
Brain, Testes, Eye, Endothelial, Bone, Heart

Publications for Developmental Coordination Disorder

Articles related to Developmental Coordination Disorder:

(show top 50) (show all 661)
# Title Authors Year
1
Children with Autism Spectrum Disorder, Developmental Coordination Disorder, and typical development differ in characteristics of dynamic postural control: A preliminary study. ( 30245240 )
2019
2
Linear and Nonlinear Analyses of the Cardiac Autonomic Control in Children With Developmental Coordination Disorder: A Case-Control Study. ( 29623050 )
2018
3
Quality of life and psychosocial functioning in adolescents with developmental coordination disorder and attention-deficit-hyperactivity disorder. ( 29727010 )
2018
4
Evaluating the evidence for motor-based interventions in developmental coordination disorder: A systematic review and meta-analysis. ( 29413431 )
2018
5
Leg muscle activation patterns during walking and leg lean mass are different in children with and without developmental coordination disorder. ( 29275080 )
2018
6
Developmental Coordination Disorder and Its Association With Developmental Comorbidities at 6.5 Years in Apparently Healthy Children Born Extremely Preterm. ( 29868837 )
2018
7
Comparing Attention to Socially-Relevant Stimuli in Autism Spectrum Disorder and Developmental Coordination Disorder. ( 29313185 )
2018
8
Participation and needs of children with developmental coordination disorder at home and in the community: Perceptions of children and parents. ( 29245043 )
2018
9
Does the Movement Assessment Battery for Children-2 at 3 years of age predict developmental coordination disorder at 4.5 years of age in children born very preterm? ( 29653831 )
2018
10
Health-related quality of life and peer relationships in adolescents with developmental coordination disorder and attention-deficit-hyperactivity disorder. ( 29611868 )
2018
11
Effects of practice on visual finger-force control in children at risk of developmental coordination disorder. ( 29699866 )
2018
12
Sensory and motor differences in Autism Spectrum Conditions and developmental coordination disorder in children: A cross-syndrome study. ( 29408162 )
2018
13
Developmental coordination disorder, psychopathology and IQ in 22q11.2 deletion syndrome. ( 29433607 )
2018
14
Nature of motor impairments in autism spectrum disorder: A comparison with developmental coordination disorder. ( 29923455 )
2018
15
Corticospinal excitability during motor imagery is reduced in young adults with developmental coordination disorder. ( 29195158 )
2018
16
Motor Competence Levels and Prevalence of Developmental Coordination Disorder in Spanish Children: The MOVI-KIDS Study. ( 29864209 )
2018
17
Developmental coordination disorder: the role of executive functions. ( 29333599 )
2018
18
Differences in accuracy and vividness of motor imagery in children with and without Developmental Coordination Disorder. ( 29966867 )
2018
19
Subtyping children with developmental coordination disorder based on physical fitness outcomes. ( 29852337 )
2018
20
Success in Adults With Probable Developmental Coordination Disorder Using Structural Equation Modeling. ( 29426379 )
2018
21
Is auditory perceptual timing a core deficit of developmental coordination disorder? ( 29741273 )
2018
22
Motor Skill Interventions in Children with Developmental Coordination Disorder: A Systematic Review and Meta-Analysis. ( 29329670 )
2018
23
The brains of children with developmental coordination disorder. ( 29298759 )
2018
24
Interhemispheric Cortical Inhibition Is Reduced in Young Adults With Developmental Coordination Disorder. ( 29628909 )
2018
25
Motor Planning and Gait Coordination Assessments for Children with Developmental Coordination Disorder. ( 29851530 )
2018
26
Health-related quality of life of children with Developmental Coordination Disorder. ( 29907374 )
2018
27
Variability in coordination patterns in children with developmental coordination disorder (DCD). ( 29957424 )
2018
28
Developmental dysgraphia is often associated with minor neurological dysfunction in children with developmental coordination disorder (DCD). ( 29605507 )
2018
29
Differential activation of brain areas in children with developmental coordination disorder during tasks of manual dexterity: An ALE meta-analysis. ( 29339004 )
2018
30
Functional brain correlates of motor response inhibition in children with developmental coordination disorder and attention deficit/hyperactivity disorder. ( 29655169 )
2018
31
Behavioral Own-Body-Transformations in Children and Adolescents With Typical Development, Autism Spectrum Disorder, and Developmental Coordination Disorder. ( 29887813 )
2018
32
Reading and Writing Skills in Children With Specific Learning Disabilities With and Without Developmental Coordination Disorder. ( 29488824 )
2018
33
Understanding the Functional Mobility of Adults with Developmental Coordination Disorder (DCD) Through the International Classification of Functioning (ICF). ( 29497595 )
2018
34
Understanding Organisational Ability and Self-Regulation in Children with Developmental Coordination Disorder. ( 29497596 )
2018
35
Reactive balance performance and neuromuscular and cognitive responses to unpredictable balance perturbations in children with developmental coordination disorder. ( 29501972 )
2018
36
Psychometric properties of field-based anaerobic capacity tests in children with Developmental Coordination Disorder. ( 29509037 )
2018
37
Feedforward motor control in developmental dyslexia and developmental coordination disorder: Does comorbidity matter? ( 29547764 )
2018
38
Deficits in Visuo-Motor Temporal Integration Impacts Manual Dexterity in Probable Developmental Coordination Disorder. ( 29556211 )
2018
39
Wrist position sense acuity and its relation to motor dysfunction in children with developmental coordination disorder. ( 29559417 )
2018
40
Role of Pediatric Physical Therapists in Promoting Sports Participation in Developmental Coordination Disorder. ( 29578996 )
2018
41
Commentary on "Role of Pediatric Physical Therapists in Promoting Sports Participation in Developmental Coordination Disorder". ( 29578997 )
2018
42
Physiological characteristics, self-perceptions, and parental support of physical activity in children with, or at risk of, developmental coordination disorder. ( 29914720 )
2018
43
We12BFit!-Improving lifestyle physical activity in children aged 7-12 years with developmental coordination disorder: protocol of a multicentre single-arm mixed-method study. ( 29950462 )
2018
44
Adapted Taekwondo Training for Prepubertal Children with Developmental Coordination Disorder: A Randomized, Controlled Trial. ( 29985447 )
2018
45
Participation of children with developmental coordination disorder. ( 30041931 )
2018
46
Exploring relationships between joint hypermobility and neurodevelopment in children (4-13 years) with hereditary connective tissue disorders and developmental coordination disorder. ( 30070022 )
2018
47
Daily motor characteristics in children with developmental coordination disorder and in children with specific learning disorder. ( 30094891 )
2018
48
Y-Balance Test Performance and Leg Muscle Activations of Children with Developmental Coordination Disorder. ( 30095371 )
2018
49
Visual tracking behaviour of two-handed catching in boys with developmental coordination disorder. ( 30097307 )
2018
50
Suboptimal bone status for adolescents with low motor competence and developmental coordination disorder-It's sex specific. ( 30119956 )
2018

Variations for Developmental Coordination Disorder

Expression for Developmental Coordination Disorder

Search GEO for disease gene expression data for Developmental Coordination Disorder.

Pathways for Developmental Coordination Disorder

GO Terms for Developmental Coordination Disorder

Molecular functions related to Developmental Coordination Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lyase activity GO:0016829 8.62 FTCD PTS

Sources for Developmental Coordination Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....