MCID: DVL001
MIFTS: 38

Developmental Coordination Disorder

Categories: Mental diseases, Neuronal diseases

Aliases & Classifications for Developmental Coordination Disorder

MalaCards integrated aliases for Developmental Coordination Disorder:

Name: Developmental Coordination Disorder 12 77 15 74
Motor Skills Disorders 45 74

Classifications:



External Ids:

Disease Ontology 12 DOID:9923
ICD9CM 36 315.4
MeSH 45 D019957
NCIt 51 C92561
SNOMED-CT 69 27544004
ICD10 34 F82

Summaries for Developmental Coordination Disorder

Disease Ontology : 12 A specific developmental disorder that involves disordered motor skills where coordinated muscle movement is impaired.

MalaCards based summary : Developmental Coordination Disorder, also known as motor skills disorders, is related to developmental dyspraxia and dysgraphia, and has symptoms including ataxia and clumsiness. An important gene associated with Developmental Coordination Disorder is RBFOX1 (RNA Binding Fox-1 Homolog 1). The drugs Dopamine and Methylphenidate have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and eye, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 77 Developmental coordination disorder (DCD), also known as developmental motor coordination disorder,... more...

Related Diseases for Developmental Coordination Disorder

Graphical network of the top 20 diseases related to Developmental Coordination Disorder:



Diseases related to Developmental Coordination Disorder

Symptoms & Phenotypes for Developmental Coordination Disorder

UMLS symptoms related to Developmental Coordination Disorder:


ataxia, clumsiness

GenomeRNAi Phenotypes related to Developmental Coordination Disorder according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-101 9.36 ELP4 GAP43
2 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.36 GAP43
3 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.36 ELP4
4 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.36 ELP4
5 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.36 GAP43
6 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.36 GAP43
7 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.36 ELP4
8 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.36 ELP4
9 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.36 GAP43
10 Increased shRNA abundance (Z-score > 2) GR00366-A-6 9.36 ELP4

Drugs & Therapeutics for Developmental Coordination Disorder

Drugs for Developmental Coordination Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 53)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 3,Phase 2 62-31-7, 51-61-6 681
2
Methylphenidate Approved, Investigational Phase 4,Not Applicable 113-45-1 4158
3 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
4 Dopamine Agents Phase 4,Phase 3,Phase 2
5 Neurotransmitter Uptake Inhibitors Phase 4
6 Dopamine Uptake Inhibitors Phase 4
7 Central Nervous System Stimulants Phase 4,Not Applicable
8
Levodopa Approved Phase 3,Phase 2 59-92-7 6047
9
Carbidopa Approved Phase 3 28860-95-9 34359
10
Droxidopa Approved, Investigational Phase 3 23651-95-8 443940
11
Entacapone Approved, Investigational Phase 3 130929-57-6 5281081
12
Tramiprosate Investigational Phase 3 3687-18-1
13
Xaliproden Investigational Phase 3 135354-02-8, 428863-50-7 128919
14 Anticonvulsants Phase 3
15 GABA Agents Phase 3
16 GABA Agonists Phase 3
17 Olive Phase 3
18 Omega 3 Fatty Acid Phase 3
19 Serotonin Agents Phase 3
20 Serotonin 5-HT1 Receptor Agonists Phase 3
21 Serotonin Receptor Agonists Phase 3
22 Carbidopa, levodopa drug combination Phase 3
23 Dopamine agonists Phase 3
24 Adjuvants, Immunologic Phase 3
25 Antiparkinson Agents Phase 3,Phase 2
26 Aromatic Amino Acid Decarboxylase Inhibitors Phase 3
27 Immunologic Factors Phase 3,Phase 1,Phase 2
28 Cardiotonic Agents Phase 3
29 Protective Agents Phase 3
30 Autonomic Agents Phase 3
31 Sympathomimetics Phase 3
32 Peripheral Nervous System Agents Phase 3
33 Catechol O-Methyltransferase Inhibitors Phase 3
34 Catechol Phase 3
35
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
36
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
37
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 46835353 6436030 5284616
38
Everolimus Approved Phase 1, Phase 2 159351-69-6 6442177 70789204
39 Dihydroxyphenylalanine Phase 2
40 Anti-Infective Agents Phase 1, Phase 2
41 Immunosuppressive Agents Phase 1, Phase 2
42 Anti-Bacterial Agents Phase 1, Phase 2
43 Antibiotics, Antitubercular Phase 1, Phase 2
44 Antifungal Agents Phase 1, Phase 2
45 Hops Approved Not Applicable
46
Pramipexole Approved, Investigational 104632-26-0 119570 59868
47
Uric Acid Experimental, Investigational Not Applicable 69-93-2 1175
48 Pharmaceutical Solutions Not Applicable
49 Antioxidants
50 Atomoxetine Hydrochloride

Interventional clinical trials:

(show top 50) (show all 53)
# Name Status NCT ID Phase Drugs
1 The Effect of Methylphenidate on Non-motor Symptoms and Postural Control in Parkinson's Disease. Terminated NCT01244269 Phase 4 Methylphenidate;Methylphenidate;Placebo 10;Placebo 20
2 Evaluation of 3APS in Patients With Mild to Moderate Alzheimer’s Disease Unknown status NCT00088673 Phase 3 3APS
3 Omega-3/Omega-6 Fatty Acids for Attention-Deficit/Hyperactivity Disorder (ADHD): A Trial in Children and Adolescents Completed NCT01219309 Phase 3
4 18-Month Study of the Efficacy of Xaliproden (SR57746A) in Patients With Mild-to-Moderate Dementia of the Alzheimer's Type Completed NCT00103649 Phase 3 xaliproden (SR57746A)
5 An Open Label Extension Study of the Safety and Clinical Utility of IPX066 in Subjects With Parkinson's Disease Completed NCT01096186 Phase 3 IPX066 95 mg;IPX066 145 mg;IPX066 195 mg;IPX066 245 mg
6 Open-Label Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH) Completed NCT00738062 Phase 3 Droxidopa;Placebo
7 Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH) Completed NCT00633880 Phase 3 Placebo;Droxidopa
8 Efficacy, Safety, and Tolerability of E2007 in Levodopa Treated Parkinson's Disease Patients With Motor Fluctuations Completed NCT00368108 Phase 3 2 mg perampanel;4 mg perampanel;placebo comparator
9 A Study to Evaluate Fixed Dose Carbidopa/Levodopa/Entacapone Versus Immediate Release Carbidopa/Levodopa Completed NCT00134966 Phase 3 capsules containing: carbidopa (25 mg), levodopa (100 mg), entacapone (200 mg)
10 Effect of tDCS on Postural Control of Children With DCD Recruiting NCT03892083 Phase 2, Phase 3
11 Safinamide in Levodopa Induced Dyskinesia in Parkinson's Disease Subjects Completed NCT01113320 Phase 2 Placebo;Safinamide
12 A Fourteen-Week Placebo-Controlled Dose-Response Efficacy and Safety Study of NS 2330 in Early Parkinson's Disease Patients (Study for Proof of Concept in Early Parkinson's Disease of a Triple Reuptake Inhibitor, NS 2330 / SCEPTRE) Completed NCT00148486 Phase 2 NS 2330
13 Evaluation of the Efficacy and Safety of AFQ056 in Reducing Moderate to Severe L-dopa Induced Dyskinesias in Patients With Parkinson's Disease Completed NCT00986414 Phase 2 AFQ056;AFQ056;AFQ056;AFQ056;AFQ056;Placebo
14 RAD001 and Neurocognition in PTEN Hamartoma Tumor Syndrome Recruiting NCT02991807 Phase 1, Phase 2 RAD001;Placebo
15 Rehabilitating Corticospinal Control of Walking Active, not recruiting NCT02132650 Phase 2
16 Effects of Delayed Cord Clamping in Very Low Birth Weight Infants Completed NCT00840983 Phase 1
17 Mental Attention-neuromuscular Training for Children With Developmental Coordination Disorder Unknown status NCT02397161 Not Applicable
18 Functional Movement-power Training for Children With Developmental Coordination Disorder: A Randomised Controlled Trial Unknown status NCT02393404 Not Applicable
19 The Effect of Virtual Reality on Motor Functioning and Participation Abilities Among Children With DCD Unknown status NCT02504385 Not Applicable
20 Characterization of Executive Functions and Patterns of Eye Movements in Children With Developmental Disabilities Unknown status NCT00716235
21 The Effects of a Group-based Gaze Training Intervention for Children With Developmental Coordination Disorder Completed NCT02904980 Not Applicable
22 Efficacy of the CO-OP Approach With Brazilian Children With Developmental Coordination Disorder Completed NCT03112746 Not Applicable
23 Fitball Program Versus Task-oriented Motor Program on Improving Postural Control in Developmental Coordination Disorder Completed NCT01207544 Not Applicable
24 Functional MRI Study in Children With a Developmental Coordination Disorder (DCD) and/or Developmental Dyslexia (DD) Completed NCT02393729 Not Applicable
25 A Teleintervention in Developmental Coordination Disorder Completed NCT03141333 Not Applicable
26 Effects of CO-OP Approach on Activity and Participation of Brazilian Children With Developmental Coordination Disorder Completed NCT02893852 Not Applicable
27 Characteristic of Play: Comparison Between Children With Development Coordination Disorder ( DCD) and Children With Typical Development Completed NCT01130038
28 Developing and Evaluating a Meta-cognitive Intervention Amongst Adolescents With Neuro-development Disabilities Completed NCT03618563 Not Applicable
29 Helping Our Premature Infants ON to Better Motor Skills (HOP-ON) Completed NCT01281358 Not Applicable
30 The Role of Brain-derived Neurotropic Factor in the Relationship Between Executive Function and Physical Training Completed NCT02503579 Not Applicable
31 Differences in Muscle Activity Patterns and Graphical Product Quality in Children With Graphomotor Impairment Copying and Tracing Activities on Horizontal or Vertical Surfaces Completed NCT02501590
32 Hippotherapy to Improve the Balance of Children With Movement Disorders Completed NCT01313325 Not Applicable
33 A Study of Neurophysiologically Based Occupational Therapy Intervention (NBOTI) for Feeding in the NCCU. Completed NCT00766051 Not Applicable
34 Profile of Newborn Undergoing Early Stimulation in a Neonatal Intensive Care Unit Completed NCT01660178
35 Impulse Control Disorders in Parkinson's Patients Treated With Pramipexole and Other Agents (DOMINION Study) Completed NCT00617019
36 Co Morbid Attention Deficit and Hyperactivity Disorder(ADHD) and Developmental Co Ordination Disorder (DCD) Recruiting NCT03595826 Not Applicable Neurostimulant pharmaceutical drugs
37 Development of Children With DCD Before the Age of Six Recruiting NCT03690843
38 Does tDCS Improve Motor Learning in Children With DCD? Recruiting NCT03453983 Not Applicable
39 Taekwondo for Children With Developmental Coordination Disorder Recruiting NCT02635711 Not Applicable
40 DCD Imaging-Intervention Study Recruiting NCT02597751 Not Applicable
41 Reliability and Validity of a Computerized Tool to Assess Proprioception and Motor Planning Among Children With Coordination Disorders Recruiting NCT03285776
42 Neurobehavioural Development of Infants Born <30 Weeks Gestational Age Between Birth and Five Years of Age Recruiting NCT03172104
43 Identification of Neuropsychological, Genetic and Neuroimaging Markers and Treatment Response Predictors of ADHD Recruiting NCT02430896 Methylphenidate (MPH);Atomoxetine
44 Tai Chi Training for Children With ADHD Recruiting NCT02234557 Not Applicable
45 tES With Random Noise Stimulation Applied to Children With Brain Injury Recruiting NCT02656433 Not Applicable
46 Rhythmic Motor Learning in Children With Developmental Coordination Disorders Active, not recruiting NCT03150784 Not Applicable
47 Taping for Children With and Without Movement Clumsiness Active, not recruiting NCT02945124 Not Applicable
48 Exploring the Impact and Feasibility of a Pathway to Sport and Long-term Participation in Young People Enrolling by invitation NCT02517333 Not Applicable
49 Evolution of Maternal Weight During Pregnancy and Influence on the Endothelial Function in Her Offspring Enrolling by invitation NCT02992106 Not Applicable
50 Gait and Muscle Power Training for Children With Developmental Coordination Disorder Not yet recruiting NCT03838614 Not Applicable

Search NIH Clinical Center for Developmental Coordination Disorder

Cochrane evidence based reviews: motor skills disorders

Genetic Tests for Developmental Coordination Disorder

Anatomical Context for Developmental Coordination Disorder

MalaCards organs/tissues related to Developmental Coordination Disorder:

42
Brain, Testes, Eye, Endothelial, Bone, Heart

Publications for Developmental Coordination Disorder

Articles related to Developmental Coordination Disorder:

(show top 50) (show all 678)
# Title Authors Year
1
Children with Autism Spectrum Disorder, Developmental Coordination Disorder, and typical development differ in characteristics of dynamic postural control: A preliminary study. ( 30245240 )
2019
2
Do video game interventions improve motor outcomes in children with developmental coordination disorder? A systematic review using the ICF framework. ( 30651097 )
2019
3
Prevalence of suspected developmental coordination disorder and associated factors in Spanish classrooms. ( 30654220 )
2019
4
International clinical practice recommendations on the definition, diagnosis, assessment, intervention, and psychosocial aspects of developmental coordination disorder. ( 30671947 )
2019
5
Risk of Developmental Coordination Disorder in Italian very preterm children at school age compared to general population controls. ( 30711366 )
2019
6
Effect of Kinesio taping on electromyographic activity of leg muscles during gait in children with developmental coordination disorder: A randomized controlled trial. ( 30732198 )
2019
7
Developmental coordination disorder continues to evolve. ( 30734941 )
2019
8
Gaze training supports self-organization of movement coordination in children with developmental coordination disorder. ( 30737438 )
2019
9
Haptic perception is altered in children with developmental coordination disorder. ( 30738812 )
2019
10
The Impact of Equine Therapy and an Audio-Visual Approach Emphasizing Rhythm and Beat Perception in Children with Developmental Coordination Disorder. ( 30789282 )
2019
11
Is Wii-based motor training better than task-specific matched training for children with developmental coordination disorder? A randomized controlled trial. ( 30794762 )
2019
12
Finger soaking enhances effects of light touch on reducing body sway in children with developmental coordination disorder. ( 30815705 )
2019
13
External focus of attention concurrently elicits optimal performance of suprapostural pole-holding task and postural stability in children with developmental coordination disorder. ( 30872044 )
2019
14
A school-based physical activity intervention for children with developmental coordination disorder: A randomized controlled trial. ( 30875607 )
2019
15
Very preterm children at risk for developmental coordination disorder have brain alterations in motor areas. ( 30891804 )
2019
16
Linear and Nonlinear Analyses of the Cardiac Autonomic Control in Children With Developmental Coordination Disorder: A Case-Control Study. ( 29623050 )
2018
17
Quality of life and psychosocial functioning in adolescents with developmental coordination disorder and attention-deficit-hyperactivity disorder. ( 29727010 )
2018
18
Evaluating the evidence for motor-based interventions in developmental coordination disorder: A systematic review and meta-analysis. ( 29413431 )
2018
19
Leg muscle activation patterns during walking and leg lean mass are different in children with and without developmental coordination disorder. ( 29275080 )
2018
20
Developmental Coordination Disorder and Its Association With Developmental Comorbidities at 6.5 Years in Apparently Healthy Children Born Extremely Preterm. ( 29868837 )
2018
21
Comparing Attention to Socially-Relevant Stimuli in Autism Spectrum Disorder and Developmental Coordination Disorder. ( 29313185 )
2018
22
Participation and needs of children with developmental coordination disorder at home and in the community: Perceptions of children and parents. ( 29245043 )
2018
23
Does the Movement Assessment Battery for Children-2 at 3 years of age predict developmental coordination disorder at 4.5 years of age in children born very preterm? ( 29653831 )
2018
24
Health-related quality of life and peer relationships in adolescents with developmental coordination disorder and attention-deficit-hyperactivity disorder. ( 29611868 )
2018
25
Effects of practice on visual finger-force control in children at risk of developmental coordination disorder. ( 29699866 )
2018
26
Sensory and motor differences in Autism Spectrum Conditions and developmental coordination disorder in children: A cross-syndrome study. ( 29408162 )
2018
27
Developmental coordination disorder, psychopathology and IQ in 22q11.2 deletion syndrome. ( 29433607 )
2018
28
Nature of motor impairments in autism spectrum disorder: A comparison with developmental coordination disorder. ( 29923455 )
2018
29
Corticospinal excitability during motor imagery is reduced in young adults with developmental coordination disorder. ( 29195158 )
2018
30
Motor Competence Levels and Prevalence of Developmental Coordination Disorder in Spanish Children: The MOVI-KIDS Study. ( 29864209 )
2018
31
Developmental coordination disorder: the role of executive functions. ( 29333599 )
2018
32
Differences in accuracy and vividness of motor imagery in children with and without Developmental Coordination Disorder. ( 29966867 )
2018
33
Subtyping children with developmental coordination disorder based on physical fitness outcomes. ( 29852337 )
2018
34
Success in Adults With Probable Developmental Coordination Disorder Using Structural Equation Modeling. ( 29426379 )
2018
35
Is auditory perceptual timing a core deficit of developmental coordination disorder? ( 29741273 )
2018
36
Motor Skill Interventions in Children with Developmental Coordination Disorder: A Systematic Review and Meta-Analysis. ( 29329670 )
2018
37
The brains of children with developmental coordination disorder. ( 29298759 )
2018
38
Interhemispheric Cortical Inhibition Is Reduced in Young Adults With Developmental Coordination Disorder. ( 29628909 )
2018
39
Motor Planning and Gait Coordination Assessments for Children with Developmental Coordination Disorder. ( 29851530 )
2018
40
Health-related quality of life of children with Developmental Coordination Disorder. ( 29907374 )
2018
41
Variability in coordination patterns in children with developmental coordination disorder (DCD). ( 29957424 )
2018
42
Developmental dysgraphia is often associated with minor neurological dysfunction in children with developmental coordination disorder (DCD). ( 29605507 )
2018
43
Differential activation of brain areas in children with developmental coordination disorder during tasks of manual dexterity: An ALE meta-analysis. ( 29339004 )
2018
44
We12BFit!-Improving lifestyle physical activity in children aged 7-12 years with developmental coordination disorder: protocol of a multicentre single-arm mixed-method study. ( 29950462 )
2018
45
Functional brain correlates of motor response inhibition in children with developmental coordination disorder and attention deficit/hyperactivity disorder. ( 29655169 )
2018
46
Behavioral Own-Body-Transformations in Children and Adolescents With Typical Development, Autism Spectrum Disorder, and Developmental Coordination Disorder. ( 29887813 )
2018
47
Physiological characteristics, self-perceptions, and parental support of physical activity in children with, or at risk of, developmental coordination disorder. ( 29914720 )
2018
48
Atypical inter-hemispheric communication correlates with altered motor inhibition during learning of a new bimanual coordination pattern in developmental coordination disorder. ( 28440058 )
2018
49
Developmental coordination disorder and its cause: The road less travelled. ( 28465073 )
2018
50
Local dynamic stability during treadmill walking can detect children with developmental coordination disorder. ( 29028627 )
2018

Variations for Developmental Coordination Disorder

Expression for Developmental Coordination Disorder

Search GEO for disease gene expression data for Developmental Coordination Disorder.

Pathways for Developmental Coordination Disorder

GO Terms for Developmental Coordination Disorder

Molecular functions related to Developmental Coordination Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lyase activity GO:0016829 8.62 FTCD PTS

Sources for Developmental Coordination Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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