MCID: DVL001
MIFTS: 36

Developmental Coordination Disorder

Categories: Mental diseases

Aliases & Classifications for Developmental Coordination Disorder

MalaCards integrated aliases for Developmental Coordination Disorder:

Name: Developmental Coordination Disorder 12 76 15 73
Motor Skills Disorders 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:9923
ICD10 33 F82
ICD9CM 35 315.4
MeSH 44 D019957
NCIt 50 C92561
SNOMED-CT 68 192578006 27544004

Summaries for Developmental Coordination Disorder

Disease Ontology : 12 A specific developmental disorder that involves disordered motor skills where coordinated muscle movement is impaired.

MalaCards based summary : Developmental Coordination Disorder, also known as motor skills disorders, is related to developmental dyspraxia and dysgraphia, and has symptoms including ataxia and clumsiness. An important gene associated with Developmental Coordination Disorder is RBFOX1 (RNA Binding Fox-1 Homolog 1). The drugs Olive and Omega 3 Fatty Acid have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and eye, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Developmental coordination disorder (DCD), also known as developmental dyspraxia or simply dyspraxia, is... more...

Related Diseases for Developmental Coordination Disorder

Diseases related to Developmental Coordination Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 29)
# Related Disease Score Top Affiliating Genes
1 developmental dyspraxia 11.8
2 dysgraphia 11.1
3 attention deficit-hyperactivity disorder 10.4
4 aging 10.4
5 autism 10.3
6 autism spectrum disorder 10.2
7 dysphasia, familial developmental 10.1
8 specific language impairment 10.1
9 cerebritis 10.0
10 dyslexia 10.0
11 neuronitis 10.0
12 niemann-pick disease, type c1 9.9
13 oculocerebral syndrome with hypopigmentation 9.9
14 cerebral palsy 9.9
15 niemann-pick disease 9.9
16 learning disability 9.9
17 schizophrenia 9.7
18 anxiety 9.7
19 spastic hemiplegia 9.7
20 hemiplegia 9.7
21 parametritis 9.7
22 hypermobility syndrome 9.7
23 vascular disease 9.7
24 epilepsy 9.7
25 infertility 9.7
26 depression 9.7
27 hypotonia 9.7
28 spasticity 9.7
29 benign epilepsy with centrotemporal spikes 9.5 ELP4 RBFOX1

Graphical network of the top 20 diseases related to Developmental Coordination Disorder:



Diseases related to Developmental Coordination Disorder

Symptoms & Phenotypes for Developmental Coordination Disorder

UMLS symptoms related to Developmental Coordination Disorder:


ataxia, clumsiness

GenomeRNAi Phenotypes related to Developmental Coordination Disorder according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-101 9.36 ELP4 GAP43
2 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.36 GAP43
3 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.36 ELP4
4 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.36 ELP4
5 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.36 GAP43
6 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.36 GAP43
7 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.36 ELP4
8 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.36 ELP4
9 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.36 GAP43
10 Increased shRNA abundance (Z-score > 2) GR00366-A-6 9.36 ELP4

Drugs & Therapeutics for Developmental Coordination Disorder

Drugs for Developmental Coordination Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Olive Nutraceutical Phase 3
2 Omega 3 Fatty Acid Nutraceutical Phase 3
3
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
4
Everolimus Approved Phase 1, Phase 2 159351-69-6 6442177
5
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 5284616 6436030 46835353
6 Anti-Bacterial Agents Phase 1, Phase 2
7 Antibiotics, Antitubercular Phase 1, Phase 2
8 Immunosuppressive Agents Phase 1, Phase 2
9 Anti-Infective Agents Phase 1, Phase 2
10 Antifungal Agents Phase 1, Phase 2
11
Menthol Approved Not Applicable 2216-51-5 16666
12
Dopamine Approved 51-61-6, 62-31-7 681
13
Methylphenidate Approved, Investigational 113-45-1 4158
14 Hops Approved, Nutraceutical Not Applicable
15
Uric Acid Experimental, Investigational Not Applicable 69-93-2 1175
16 Adrenergic Agents
17 Central Nervous System Stimulants ,Not Applicable
18 Neurotransmitter Agents
19 Neurotransmitter Uptake Inhibitors
20 Dopamine Agents
21 Dopamine Uptake Inhibitors
22 Atomoxetine Hydrochloride
23 Pharmaceutical Solutions Not Applicable
24 insulin Not Applicable
25 Insulin, Globin Zinc Not Applicable

Interventional clinical trials:

(show all 29)
# Name Status NCT ID Phase Drugs
1 Omega-3/Omega-6 Fatty Acids for Attention-Deficit/Hyperactivity Disorder (ADHD): A Trial in Children and Adolescents Completed NCT01219309 Phase 3
2 RAD001 and Neurocognition in PTEN Hamartoma Tumor Syndrome (PTEN) Recruiting NCT02991807 Phase 1, Phase 2 RAD001;Placebo
3 Mental Attention-neuromuscular Training for Children With Developmental Coordination Disorder Unknown status NCT02397161 Not Applicable
4 Functional Movement-power Training for Children With Developmental Coordination Disorder: A Randomised Controlled Trial Unknown status NCT02393404 Not Applicable
5 The Effect of Virtual Reality on Motor Functioning and Participation Abilities Among Children With DCD Unknown status NCT02504385 Not Applicable
6 DCD Imaging-Intervention Study Unknown status NCT02597751 Not Applicable
7 Characterization of Executive Functions and Patterns of Eye Movements in Children With Developmental Disabilities Unknown status NCT00716235
8 The Effects of a Group-based Gaze Training Intervention for Children With Developmental Coordination Disorder Completed NCT02904980 Not Applicable
9 Efficacy of the CO-OP Approach With Brazilian Children With Developmental Coordination Disorder Completed NCT03112746 Not Applicable
10 Fitball Program Versus Task-oriented Motor Program on Improving Postural Control in Developmental Coordination Disorder Completed NCT01207544 Not Applicable
11 Functional MRI Study in Children With a Developmental Coordination Disorder (DCD) and/or Developmental Dyslexia (DD) Completed NCT02393729 Not Applicable
12 A Teleintervention in Developmental Coordination Disorder Completed NCT03141333 Not Applicable
13 Characteristic of Play: Comparison Between Children With Development Coordination Disorder ( DCD) and Children With Typical Development Completed NCT01130038
14 Helping Our Premature Infants ON to Better Motor Skills (HOP-ON) Completed NCT01281358 Not Applicable
15 The Role of Brain-derived Neurotropic Factor in the Relationship Between Executive Function and Physical Training Completed NCT02503579 Not Applicable
16 Differences in Muscle Activity Patterns and Graphical Product Quality in Children With Graphomotor Impairment Copying and Tracing Activities on Horizontal or Vertical Surfaces Completed NCT02501590
17 Hippotherapy to Improve the Balance of Children With Movement Disorders Completed NCT01313325 Not Applicable
18 A Study of Neurophysiologically Based Occupational Therapy Intervention (NBOTI) for Feeding in the NCCU. Completed NCT00766051 Not Applicable
19 Taekwondo for Children With Developmental Coordination Disorder Recruiting NCT02635711 Not Applicable
20 Reliability and Validity of a Computerized Tool to Assess Proprioception and Motor Planning Among Children With Coordination Disorders Recruiting NCT03285776
21 Neurobehavioural Development of Infants Born <30 Weeks Gestational Age Between Birth and Five Years of Age Recruiting NCT03172104
22 Identification of Neuropsychological, Genetic and Neuroimaging Markers and Treatment Response Predictors of ADHD Recruiting NCT02430896 Methylphenidate (MPH);Atomoxetine
23 Tai Chi Training for Children With ADHD Recruiting NCT02234557 Not Applicable
24 Rhythmic Motor Learning in Children With Developmental Coordination Disorders Active, not recruiting NCT03150784 Not Applicable
25 Taping for Children With and Without Movement Clumsiness Active, not recruiting NCT02945124 Not Applicable
26 Effects of CO-OP Approach on Activity and Participation of Brazilian Children With Developmental Coordination Disorder Active, not recruiting NCT02893852 Not Applicable
27 Exploring the Impact and Feasibility of a Pathway to Sport and Long-term Participation in Young People Enrolling by invitation NCT02517333 Not Applicable
28 Evolution of Maternal Weight During Pregnancy and Influence on the Endothelial Function in Her Offspring Enrolling by invitation NCT02992106 Not Applicable
29 Does tDCS Improve Motor Learning in Children With DCD? Not yet recruiting NCT03453983 Not Applicable

Search NIH Clinical Center for Developmental Coordination Disorder

Cochrane evidence based reviews: motor skills disorders

Genetic Tests for Developmental Coordination Disorder

Anatomical Context for Developmental Coordination Disorder

MalaCards organs/tissues related to Developmental Coordination Disorder:

41
Brain, Testes, Eye, Endothelial, Heart, Bone

Publications for Developmental Coordination Disorder

Articles related to Developmental Coordination Disorder:

(show top 50) (show all 548)
# Title Authors Year
1
Linear and Nonlinear Analyses of the Cardiac Autonomic Control in Children With Developmental Coordination Disorder: A Case-Control Study. ( 29623050 )
2018
2
Quality of life and psychosocial functioning in adolescents with developmental coordination disorder and attention-deficit-hyperactivity disorder. ( 29727010 )
2018
3
Evaluating the evidence for motor-based interventions in developmental coordination disorder: A systematic review and meta-analysis. ( 29413431 )
2018
4
Leg muscle activation patterns during walking and leg lean mass are different in children with and without developmental coordination disorder. ( 29275080 )
2018
5
Developmental Coordination Disorder and Its Association With Developmental Comorbidities at 6.5 Years in Apparently Healthy Children Born Extremely Preterm. ( 29868837 )
2018
6
Comparing Attention to Socially-Relevant Stimuli in Autism Spectrum Disorder and Developmental Coordination Disorder. ( 29313185 )
2018
7
Participation and needs of children with developmental coordination disorder at home and in the community: Perceptions of children and parents. ( 29245043 )
2018
8
Does the Movement Assessment Battery for Children-2 at 3 years of age predict developmental coordination disorder at 4.5 years of age in children born very preterm? ( 29653831 )
2018
9
Health-related quality of life and peer relationships in adolescents with developmental coordination disorder and attention-deficit-hyperactivity disorder. ( 29611868 )
2018
10
Effects of practice on visual finger-force control in children at risk of developmental coordination disorder. ( 29699866 )
2018
11
Sensory and motor differences in Autism Spectrum Conditions and developmental coordination disorder in children: A cross-syndrome study. ( 29408162 )
2018
12
Developmental coordination disorder, psychopathology and IQ in 22q11.2 deletion syndrome. ( 29433607 )
2018
13
Nature of motor impairments in autism spectrum disorder: A comparison with developmental coordination disorder. ( 29923455 )
2018
14
Corticospinal excitability during motor imagery is reduced in young adults with developmental coordination disorder. ( 29195158 )
2018
15
Motor Competence Levels and Prevalence of Developmental Coordination Disorder in Spanish Children: The MOVI-KIDS Study. ( 29864209 )
2018
16
Developmental coordination disorder: the role of executive functions. ( 29333599 )
2018
17
Differences in accuracy and vividness of motor imagery in children with and without Developmental Coordination Disorder. ( 29966867 )
2018
18
Subtyping children with developmental coordination disorder based on physical fitness outcomes. ( 29852337 )
2018
19
Success in Adults With Probable Developmental Coordination Disorder Using Structural Equation Modeling. ( 29426379 )
2018
20
Is auditory perceptual timing a core deficit of developmental coordination disorder? ( 29741273 )
2018
21
Motor Skill Interventions in Children with Developmental Coordination Disorder: A Systematic Review and Meta-Analysis. ( 29329670 )
2018
22
The brains of children with developmental coordination disorder. ( 29298759 )
2018
23
Interhemispheric Cortical Inhibition Is Reduced in Young Adults With Developmental Coordination Disorder. ( 29628909 )
2018
24
Motor Planning and Gait Coordination Assessments for Children with Developmental Coordination Disorder. ( 29851530 )
2018
25
Health-related quality of life of children with Developmental Coordination Disorder. ( 29907374 )
2018
26
Variability in coordination patterns in children with developmental coordination disorder (DCD). ( 29957424 )
2018
27
Developmental dysgraphia is often associated with minor neurological dysfunction in children with developmental coordination disorder (DCD). ( 29605507 )
2018
28
Differential activation of brain areas in children with developmental coordination disorder during tasks of manual dexterity: An ALE meta-analysis. ( 29339004 )
2018
29
We12BFit!-Improving lifestyle physical activity in children aged 7-12 years with developmental coordination disorder: protocol of a multicentre single-arm mixed-method study. ( 29950462 )
2018
30
Functional brain correlates of motor response inhibition in children with developmental coordination disorder and attention deficit/hyperactivity disorder. ( 29655169 )
2018
31
Behavioral Own-Body-Transformations in Children and Adolescents With Typical Development, Autism Spectrum Disorder, and Developmental Coordination Disorder. ( 29887813 )
2018
32
Physiological characteristics, self-perceptions, and parental support of physical activity in children with, or at risk of, developmental coordination disorder. ( 29914720 )
2018
33
Mental health outcomes of developmental coordination disorder in late adolescence. ( 28512766 )
2017
34
Executive functions in children with developmental coordination disorder: a 2-year follow-up study. ( 29238952 )
2017
35
The Impact of Methylphenidate on Motor Performance in Children with both Attention Deficit Hyperactivity Disorder and Developmental Coordination Disorder: A Randomized Double-Blind Crossover Clinical Trial. ( 28761201 )
2017
36
Impaired postural control in children with developmental coordination disorder is related to less efficient central as well as peripheral control. ( 27693806 )
2017
37
A Range of Service Delivery Modes for Children With Developmental Coordination Disorder Are Effective: A Randomized Controlled Trial. ( 28654492 )
2017
38
Efficacy of the cognitive orientation to daily occupational performance with Brazilian children with developmental coordination disorder. ( 29260603 )
2017
39
Gait symmetry in individuals with and without Developmental Coordination Disorder. ( 27912103 )
2017
40
Children With Developmental Coordination Disorder. ( 28558620 )
2017
41
Corrigendum to &amp;quot;Niemann-Pick Disease Type C Presenting as a Developmental Coordination Disorder with Bullying by Peers in a School-Age Child&amp;quot;. ( 29085694 )
2017
42
White matter alterations in adults with probable developmental coordination disorder: an MRI diffusion tensor imaging study. ( 27902527 )
2017
43
Diversity of activity participation determines bone mineral content in the lower limbs of pre-pubertal children with developmental coordination disorder. ( 29285628 )
2017
44
Emotional and behavioural problems in children with Developmental Coordination Disorder: Exploring parent and teacher reports. ( 28915470 )
2017
45
Understanding why an active video game intervention did not improve motor skill and physical activity in children with developmental coordination disorder: A quantity or quality issue? ( 27863326 )
2017
46
Cognitive and neuroimaging findings in developmental coordination disorder: new insights from a systematic review of recent research. ( 28872667 )
2017
47
Lack of Motor Inhibition as a Marker of Learning Difficulties of Bimanual Coordination in Teenagers With Developmental Coordination Disorder. ( 28481145 )
2017
48
Cortical activity in fine-motor tasks in children with Developmental Coordination Disorder: A preliminary fNIRS study. ( 29126862 )
2017
49
Insights in Developmental Coordination Disorder. ( 28745216 )
2017
50
Commentary on &amp;quot;A Range of Service Delivery Modes for Children With Developmental Coordination Disorder Are Effective: A Randomized Controlled Trial&amp;quot;. ( 28654493 )
2017

Variations for Developmental Coordination Disorder

Expression for Developmental Coordination Disorder

Search GEO for disease gene expression data for Developmental Coordination Disorder.

Pathways for Developmental Coordination Disorder

GO Terms for Developmental Coordination Disorder

Molecular functions related to Developmental Coordination Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lyase activity GO:0016829 8.62 FTCD PTS

Sources for Developmental Coordination Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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