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MCID: DVL012
MIFTS: 35

Developmental Dysplasia of the Hip 1

Categories: Rare diseases
Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs
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Aliases & Classifications for Developmental Dysplasia of the Hip 1

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MalaCards integrated aliases for Developmental Dysplasia of the Hip 1:

Name: Developmental Dysplasia of the Hip 1 57 73
Acetabular Dysplasia 57 29 13
Hip Dysplasia, Developmental; Ddh 57
Hip Dysplasia, Congenital; Cdh 57
Developmental Dysplasia of Hip 53
Hip Dysplasia, Developmental 57
Congenital Dysplasia of Hip 53
Hip Dysplasia, Congenital 57
Ddh1 57
Ddh 57
Cdh 57

Characteristics:

OMIM:

57
Inheritance:
multifactorial

Miscellaneous:
preponderance of affected females (80%) to males
positive family history in 12-33% patients
incidence 1-1.5/1,000 live births


HPO:

32
developmental dysplasia of the hip 1:
Inheritance multifactorial inheritance


Classifications:

MalaCards categories:
Global: Rare diseases
See all MalaCards categories (disease lists)


External Ids:

OMIM 57 142700
MedGen 42 C1306065
SNOMED-CT via HPO 69 48334007 52781008
UMLS 73 C1306065
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Summaries for Developmental Dysplasia of the Hip 1

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OMIM : 57 Congenital dysplasia of the hip (CDH) is an abnormality of the seating of the femoral head in the acetabulum. Its severity ranges from mild instability of the femoral head with slight capsular laxity, through moderate lateral displacement of the femoral head, without loss of contact of the head with the acetabulum, up to complete dislocation of the femoral head from the acetabulum. It is one of the most common skeletal congenital anomalies (summary by Sollazzo et al., 2000). Acetabular dysplasia is an idiopathic, localized developmental dysplasia of the hip that is characterized by a shallow hip socket and decreased coverage of the femoral head. Its radiologic criteria include the center-edge angle of Wiberg, the Sharp angle, and the acetabular roof obliquity. Most patients with acetabular dysplasia develop osteoarthritis (165720) after midlife, and even mild acetabular dysplasia can cause hip osteoarthritis (summary by Mabuchi et al., 2006). CDH occurs as an isolated anomaly or with more general disorders represented by several syndromes and with chromosomal abnormalities such as trisomy 18 (Wynne-Davies, 1970). (142700)

MalaCards based summary : Developmental Dysplasia of the Hip 1, also known as acetabular dysplasia, is related to diaphragmatic hernia, congenital and craniofacial-deafness-hand syndrome. An important gene associated with Developmental Dysplasia of the Hip 1 is DDH2 (Developmental Dysplasia Of The Hip 2). The drugs Clonidine and Epinephrine have been mentioned in the context of this disorder. Affiliated tissues include bone, and related phenotypes are congenital hip dislocation and acetabular dysplasia

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Related Diseases for Developmental Dysplasia of the Hip 1

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Diseases related to Developmental Dysplasia of the Hip 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 20)
# Related Disease Score Top Affiliating Genes
1 diaphragmatic hernia, congenital 12.1
2 craniofacial-deafness-hand syndrome 11.8
3 diaphragmatic hernia 3 11.1
4 developmental dysplasia of the hip 2 11.0
5 osteoarthritis 10.5
6 cerebritis 10.0
7 aging 10.0
8 thrombophilia due to thrombin defect 10.0
9 thrombosis 10.0
10 papilledema 10.0
11 intracranial hypertension 10.0
12 torticollis 9.9
13 congenital torticollis 9.9
14 cerebral palsy 9.9
15 tracheoesophageal fistula with or without esophageal atresia 9.8
16 fryns syndrome 9.8
17 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.8
18 pulmonary hypertension 9.8
19 esophageal atresia 9.8
20 esophagitis 9.8

Graphical network of the top 20 diseases related to Developmental Dysplasia of the Hip 1:



Diseases related to Developmental Dysplasia of the Hip 1
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Symptoms & Phenotypes for Developmental Dysplasia of the Hip 1

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Symptoms via clinical synopsis from OMIM:

57
Skeletal Pelvis:
congenital hip dislocation
positive ortolani sign


Clinical features from OMIM:

142700

Human phenotypes related to Developmental Dysplasia of the Hip 1:

32
# Description HPO Frequency HPO Source Accession
1 congenital hip dislocation 32 HP:0001374
2 acetabular dysplasia 32 HP:0008807
Sources

Drugs & Therapeutics for Developmental Dysplasia of the Hip 1

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Drugs for Developmental Dysplasia of the Hip 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 51)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clonidine Approved Phase 4 4205-90-7 2803
2
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
3
Racepinephrine Approved Phase 4 329-65-7 838
4
Methyclothiazide Approved Phase 4 135-07-9 4121
5
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
6 Adrenergic Agents Phase 4
7 Adrenergic Agonists Phase 4
8 Adrenergic alpha-2 Receptor Agonists Phase 4
9 Adrenergic alpha-Agonists Phase 4
10 Adrenergic beta-Agonists Phase 4
11 Analgesics Phase 4
12 Anesthetics Phase 4,Not Applicable
13 Anesthetics, Local Phase 4,Not Applicable
14 Anti-Asthmatic Agents Phase 4
15 Antihypertensive Agents Phase 4
16 Autonomic Agents Phase 4
17 Bronchodilator Agents Phase 4
18 Epinephryl borate Phase 4
19 Mydriatics Phase 4
20 Neurotransmitter Agents Phase 4
21 Peripheral Nervous System Agents Phase 4,Not Applicable
22 Respiratory System Agents Phase 4
23 Sympatholytics Phase 4
24 Vasoconstrictor Agents Phase 4
25 Anti-Bacterial Agents Phase 4
26 Anti-Infective Agents Phase 4
27 Gentamicins Phase 4
28 diuretics Phase 4
29 Natriuretic Agents Phase 4
30 Sodium Chloride Symporter Inhibitors Phase 4
31 Antiemetics Phase 4
32 Anti-Inflammatory Agents Phase 4
33 Antineoplastic Agents, Hormonal Phase 4
34 BB 1101 Phase 4
35 Dexamethasone acetate Phase 4 1177-87-3
36 Gastrointestinal Agents Phase 4
37 glucocorticoids Phase 4
38 HIV Protease Inhibitors Phase 4
39 Hormone Antagonists Phase 4
40 Hormones Phase 4
41 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
42
protease inhibitors Phase 4
43
Ropivacaine Approved Not Applicable 84057-95-4 71273 175805
44
Salicylic acid Approved, Investigational, Vet_approved 69-72-7 338
45
Menthol Approved 2216-51-5 16666
46
Adenosine Approved, Investigational 58-61-7 60961
47
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
48 tannic acid Approved, Nutraceutical
49 Central Nervous System Depressants Not Applicable
50 Pharmaceutical Solutions Not Applicable

Interventional clinical trials:

(show top 50) (show all 90)
# Name Status NCT ID Phase Drugs
1 Hip Scope Fascia-iliaca (FI) Block Study Unknown status NCT02365961 Phase 4 ropivicaine;clonidine;Epinephrine;Noropin
2 Efficacy and Satisfaction Comparing Two Braces in the Treatment of Developmental Dysplasia of the Hip (DDH) in Infants Completed NCT01375218 Phase 4
3 A Study to Assess the Long-term Performance of SmartSet® HV and SmartSet® GHV Bone Cements in Primary Total Hip Replacement Completed NCT00872066 Phase 4
4 A Randomised Single Centre Study to Compare the Long-term Wear Characteristics of Marathonâ„¢ and Enduronâ„¢ Polyethylene Cup Liners in Primary Total Hip Replacement Completed NCT00208442 Phase 4
5 High vs Low Dose Dexamethasone on Complications in the Immediate Postoperative Phase Recruiting NCT03161938 Phase 4 Dexamethasone
6 Post Approval Study: NOVATION Ceramic Articulation Hip System Recruiting NCT00715143 Phase 4
7 Multi-centre Study to Assess the Long-term Performance of the Deltamotion Cup System in Primary Hip Replacement Surgery Active, not recruiting NCT01635166 Phase 4
8 Trilogy AB Acetabular Hip System Post Approval Study Terminated NCT00715026 Phase 4
9 Post-approval Study of the DURALOC® Option Ceramic-on-Ceramic Hip Prosthesis System Terminated NCT00546598 Phase 4
10 A Randomised Study to Compare Metal Ion Release and Long-term Performance of the Pinnacleâ„¢ Cup With a Ceramic-on-Metal or a Metal-on-Metal Bearing Terminated NCT00873444 Phase 4
11 An Electronic Data Capture Study to Assess the Long-term Performance of the DePuy PROXIMAâ„¢ Hip in Primary Total Hip Replacement Terminated NCT01134445 Phase 4
12 A Multi-centre Study to Assess the Long-term Performance of the DePuy PROXIMAâ„¢ Hip in Primary Total Hip Replacement Terminated NCT00208455 Phase 4
13 Metal on Metal Versus Metal on Highly Crossed Linked Polyethylene Sytem Terminated NCT01422564 Phase 4
14 A Single Centre Study to Assess the Long-term Performance of the DePuy ASRâ„¢ System in Primary Hip Resurfacing Surgery Terminated NCT00872794 Phase 4
15 A Two Centre Study to Assess the Stability and Long-term Performance of the C-Stemâ„¢ AMT in a Total Primary Hip Replacement Terminated NCT00872573 Phase 4
16 Multi-Centre Study to Assess the Long-term Performance of the DePuy ASRâ„¢ System in Resurfacing and Primary Total Hip Replacement Terminated NCT00872547 Phase 4
17 A Single Centre Study to Assess the Long-term Performance of the Pinnacleâ„¢ Cup With a Ceramic-on-ceramic Bearing in Primary Total Hip Replacement Terminated NCT00872222 Phase 4
18 A Multi-centre Study to Assess the Long-term Performance of the Summitâ„¢ Hip in Primary Total Hip Replacement Terminated NCT00208390 Phase 4
19 A Multi-centre Study to Assess the Long-term Performance of the DePuy ASRâ„¢ System in Primary Hip Resurfacing Surgery Terminated NCT00208377 Phase 4
20 A Two Centre Study to Assess the Long-term Performance of the Pinnacleâ„¢ Cup With a Metal-on-Metal Bearing in Primary Total Hip Replacement Terminated NCT00208364 Phase 4
21 A Multi-centre Study to Assess the Long-term Performance of the Pinnacleâ„¢ Cup With a Polyethylene-on-metal Bearing in Primary Total Hip Replacement Withdrawn NCT00208429 Phase 4
22 A Randomised Multi-centre Study to Compare the Long-term Performance of the Future Hip to 3 Other Implants in Primary Total Hip Replacement Terminated NCT00208468 Phase 3
23 A Randomised Single Centre Study to Compare the Long-term Performance of 4 Designs of the DePuy Ultima LX Stem in Primary Total Hip Replacement Terminated NCT00208351 Phase 3
24 Soft Tissue Pathology in Hip Dysplasia Before and After Periacetabular Osteotomy Unknown status NCT02311166
25 Universal Ultrasound-screening for Developmental Dysplasia of the Hip in Newborn Unknown status NCT01053299 Not Applicable
26 Modified Triple Osteotomy for Acetabular Dysplasia Unknown status NCT01285154
27 Automatic Characterization of the Neonatal Hip Using Ultrasound Imaging Unknown status NCT02796768
28 Acetabular Labral Tear in Dysplastic Hips Unknown status NCT01345838
29 Assessment of Digital Radiograph Measurements of Hip,Spine and Lower Limbs Unknown status NCT00782223
30 Movement Pattern in Patients With Hip Dysplasia Completed NCT01344421
31 Treatment for Mild Hip Dysplasia in Newborns Completed NCT00843258 Not Applicable
32 Truncal Blocks for Pediatric With Developmental Dysplasia of the Hip Undergoing Open Reduction Completed NCT03189966 Not Applicable
33 Functional Capacity After Computer Assisted Periacetabular Osteotomy in Patients With Hip Dysplasia Completed NCT02015247 Not Applicable
34 Ultrasound Screening for Developmental Dysplasia of the Hip in Newborns Completed NCT01818934 Not Applicable
35 Selective Ultrasound Screening for DDH 1991-2006 Completed NCT01866527
36 Developmental Hip Dysplasia by Ultrasonographic Screening of Asymptomatic Infants at Assiut University Hospital Completed NCT03476915
37 Predictive Factors for the Development of Osteonecrosis After the Treatment of the Developmental Dislocated Hip Completed NCT01133938
38 Retrospective Follow-up Study After Periacetabular Osteotomy in Adults Completed NCT01348178
39 Outcome After Arthroscopic Surgery in Patients Treated With PAO Completed NCT02945995
40 Psychological, Sexually and Social Consequences of Osteoarthritis Treatment With THA or TKA and Joint Preserving Surgery Completed NCT01305759
41 EBIS: The Eindhoven Breech Intervention Study Completed NCT00516555
42 Routine Follow up After Total Hip Arthroplasty Prior Periacetabular Osteotomy Completed NCT01657357
43 Periacetabular Osteotomy.A Prospective Study With Reference to Cartilage, Migration and Bone Density Completed NCT00119977 Not Applicable
44 A Clinical Trial Study of Hip System in Primary Total Hip Arthroplasty in China Completed NCT02399007 Not Applicable
45 Metal Ions in Ceramic on Metal Total Hip Arthroplasty Completed NCT01437124
46 A Clinical Investigation of the C2a-Taperâ„¢ Acetabular System Completed NCT00578851
47 Periprosthetic Bone Mineral Density After Total Hip Arthroplasty Performed Through a Minimally Invasive Anterior Approach (AMIS) With Either an AMIStem or a Quadra Femoral Component Completed NCT01285843 Not Applicable
48 Project JAY THA Registration Study Completed NCT02347384 Not Applicable
49 Research for Genetic Factors Involved in Congenital Dislocation of Hip: Genome-wide Association Study in Grand West France Recruiting NCT02900482
50 Sequelae of Developmental Dysplasia of the Hip Recruiting NCT02431871

Search NIH Clinical Center for Developmental Dysplasia of the Hip 1

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Genetic Tests for Developmental Dysplasia of the Hip 1

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Genetic tests related to Developmental Dysplasia of the Hip 1:

# Genetic test Affiliating Genes
1 Acetabular Dysplasia 29
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Anatomical Context for Developmental Dysplasia of the Hip 1

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MalaCards organs/tissues related to Developmental Dysplasia of the Hip 1:

41
Bone
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Publications for Developmental Dysplasia of the Hip 1

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Articles related to Developmental Dysplasia of the Hip 1:

(show top 50) (show all 176)
# Title Authors Year
1
Three Patterns of Acetabular Deficiency Are Common in Young Adult Patients With Acetabular Dysplasia. ( 27830486 )
2017
2
The Iliofemoral Line: A Radiographic Sign of Acetabular Dysplasia in the Adult Hip. ( 28609639 )
2017
3
Rotational acetabular osteotomy for acetabular dysplasia and osteoarthritis: a mean follow-up of 20A years. ( 28197751 )
2017
4
Patient-specific chondrolabral contact mechanics in patients with acetabular dysplasia following treatment with peri-acetabular osteotomy. ( 27923602 )
2017
5
Multiple epiphyseal dysplasia mimicking osteoarthritis due to acetabular dysplasia: A report of a familial case with a COMP mutation. ( 26920793 )
2016
6
Are there sex-dependent differences in acetabular dysplasia characteristics? ( 25637398 )
2015
7
Does Labral Size Correlate With Degree of Acetabular Dysplasia? ( 26535386 )
2015
8
Focal concavity of posterior superior acetabulum and its relation with acetabular dysplasia and retroversion in adults without advanced hip osteoarthritis. ( 26527292 )
2015
9
Postural correction reduces hip pain in adult with acetabular dysplasia: A case report. ( 25731688 )
2015
10
A novel classification to guide total hip arthroplasty for adult acetabular dysplasia. ( 23935749 )
2013
11
Is there a role for acetabular dysplasia correction in an asymptomatic patient? ( 23764798 )
2013
12
Abduction bracing for residual acetabular dysplasia in infantile DDH. ( 23812157 )
2013
13
Demographic differences in adolescent-diagnosed and adult-diagnosed acetabular dysplasia compared with infantile developmental dysplasia of the hip. ( 23389561 )
2013
14
Pincer deformity does not lead to osteoarthritis of the hip whereas acetabular dysplasia does: acetabular coverage and development of osteoarthritis in a nationwide prospective cohort study (CHECK). ( 23850552 )
2013
15
Effect of acetabular reinforcement ring with hook for acetabular dysplasia clarified by three-dimensional finite element analysis. ( 23993349 )
2013
16
Femoral head deformity and severity of acetabular dysplasia of the hip. ( 23997130 )
2013
17
Acetabular dysplasia at the age of 1 year in children with neonatal instability of the hip. ( 24171679 )
2013
18
Alternatives to periacetabular osteotomy for adult acetabular dysplasia. ( 23395034 )
2013
19
Selective epiphysiodesis of the triradiate cartilage for treatment of residual experimental acetabular dysplasia. ( 23812147 )
2013
20
Segmental copy number loss in the region of Semaphorin 4D gene in patients with acetabular dysplasia. ( 23335257 )
2013
21
Rotational acetabular osteotomy through an Ollier lateral U approach for early-stage osteoarthritis secondary to acetabular dysplasia. ( 23420742 )
2013
22
Patient-specific analysis of cartilage and labrum mechanics in human hips with acetabular dysplasia. ( 24269633 )
2013
23
What is the evidence to support acetabular dysplasia as a cause of osteoarthritis? ( 23764788 )
2013
24
How to choose the right patient for correction of acetabular dysplasia after skeletal maturity. ( 23764785 )
2013
25
Dome osteotomy of the pelvis using a modified trochanteric osteotomy for acetabular dysplasia. ( 21533997 )
2012
26
Modified triple innominate osteotomy for acetabular dysplasia: for better femoral head medialization and coverage. ( 22186704 )
2012
27
Dega osteotomy for the correction of acetabular dysplasia of the hip: a radiographic review of 21 cases. ( 22327443 )
2012
28
High survivorship of cemented sockets with roof graft for severe acetabular dysplasia. ( 22492173 )
2012
29
Evaluation of radial distribution of cartilage degeneration and necessity of pre-contrast measurements using radial dGEMRIC in adults with acetabular dysplasia. ( 23110607 )
2012
30
Midterm results of transtrochanteric anterior rotational osteotomy combined with shelf acetabuloplasty for osteonecrosis with acetabular dysplasia: a preliminary report. ( 22406867 )
2012
31
Hip acetabular dysplasia and joint laxity of female anterior cruciate ligament-injured patients. ( 21051427 )
2011
32
Responsiveness of the SF-36 and WOMAC following periacetabular osteotomy for acetabular dysplasia. ( 22159857 )
2011
33
Clinical presentation of symptomatic acetabular dysplasia in skeletally mature patients. ( 21543683 )
2011
34
Osteoarthritis hip joints in Japan: involvement of acetabular dysplasia. ( 21359510 )
2011
35
Arthroscopic disease classification and interventions as an adjunct in the treatment of acetabular dysplasia. ( 21709035 )
2011
36
Measuring acetabular dysplasia in plain radiographs. ( 21360130 )
2011
37
Periacetabular osteotomy after failed hip arthroscopy for labral tears in patients with acetabular dysplasia. ( 21543690 )
2011
38
The Shenton line in the diagnosis of acetabular dysplasia in the skeletally mature patient. ( 21543686 )
2011
39
Effect of kampo medicine on pain and range of motion of osteoarthritis of the hip accompanied by acetabular dysplasia: case report and literature review. ( 22174570 )
2011
40
Outcome of periacetabular osteotomy for the management of acetabular dysplasia: experience in an academic centre. ( 21473443 )
2011
41
Relationship of acetabular dysplasia and femoroacetabular impingement to hip osteoarthritis: a focused review. ( 22108232 )
2011
42
Analysis of interobserver reliability for radiographic staging of coxarthrosis and indexes of acetabular dysplasia: a preliminary study. ( 20151246 )
2010
43
Treatment for acetabular dysplasia using the uncemented RM acetabular component - a 20 year follow-up. ( 20853254 )
2010
44
Effect of periacetabular osteotomy for acetabular dysplasia clarified by three-dimensional finite element analysis. ( 20953924 )
2010
45
Mild acetabular dysplasia and risk of osteoarthritis of the hip: a case-control study. ( 20472600 )
2010
46
Intracapsular pressure and interleukin-1beta cytokine in hips with acetabular dysplasia. ( 20367415 )
2010
47
Treatment for acetabular dysplasia using the uncemented RM acetabular component - a 20 year follow-up. ( 20563996 )
2010
48
Increasing thickness and fibrosis of the cartilage in acetabular dysplasia: a rabbit model research. ( 21162956 )
2010
49
Early catastrophic failure of Birmingham acetabular dysplasia cup in revision arthroplasty: a case report. ( 19830096 )
2009
50
Three-dimensional computed tomography analysis of non-osteoarthritic adult acetabular dysplasia. ( 18830593 )
2009
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Variations for Developmental Dysplasia of the Hip 1

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Expression for Developmental Dysplasia of the Hip 1

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Search GEO for disease gene expression data for Developmental Dysplasia of the Hip 1.
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Pathways for Developmental Dysplasia of the Hip 1

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GO Terms for Developmental Dysplasia of the Hip 1

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Sources for Developmental Dysplasia of the Hip 1

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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