CDH
MCID: DVL012
MIFTS: 33

Developmental Dysplasia of the Hip 1 (CDH)

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Developmental Dysplasia of the Hip 1

MalaCards integrated aliases for Developmental Dysplasia of the Hip 1:

Name: Developmental Dysplasia of the Hip 1 57 73
Acetabular Dysplasia 57 29 13
Hip Dysplasia, Developmental; Ddh 57
Hip Dysplasia, Congenital; Cdh 57
Developmental Dysplasia of Hip 53
Hip Dysplasia, Developmental 57
Congenital Dysplasia of Hip 53
Hip Dysplasia, Congenital 57
Ddh1 57
Ddh 57
Cdh 57

Characteristics:

OMIM:

57
Inheritance:
multifactorial

Miscellaneous:
preponderance of affected females (80%) to males
positive family history in 12-33% patients
incidence 1-1.5/1,000 live births


HPO:

32
developmental dysplasia of the hip 1:
Inheritance multifactorial inheritance


Classifications:



External Ids:

OMIM 57 142700
MedGen 42 C1306065
SNOMED-CT via HPO 69 48334007 52781008
UMLS 73 C1306065

Summaries for Developmental Dysplasia of the Hip 1

OMIM : 57 Congenital dysplasia of the hip (CDH) is an abnormality of the seating of the femoral head in the acetabulum. Its severity ranges from mild instability of the femoral head with slight capsular laxity, through moderate lateral displacement of the femoral head, without loss of contact of the head with the acetabulum, up to complete dislocation of the femoral head from the acetabulum. It is one of the most common skeletal congenital anomalies (summary by Sollazzo et al., 2000). Acetabular dysplasia is an idiopathic, localized developmental dysplasia of the hip that is characterized by a shallow hip socket and decreased coverage of the femoral head. Its radiologic criteria include the center-edge angle of Wiberg, the Sharp angle, and the acetabular roof obliquity. Most patients with acetabular dysplasia develop osteoarthritis (165720) after midlife, and even mild acetabular dysplasia can cause hip osteoarthritis (summary by Mabuchi et al., 2006). CDH occurs as an isolated anomaly or with more general disorders represented by several syndromes and with chromosomal abnormalities such as trisomy 18 (Wynne-Davies, 1970). (142700)

MalaCards based summary : Developmental Dysplasia of the Hip 1, also known as acetabular dysplasia, is related to diaphragmatic hernia, congenital and craniofacial-deafness-hand syndrome. An important gene associated with Developmental Dysplasia of the Hip 1 is DDH2 (Developmental Dysplasia Of The Hip 2). Affiliated tissues include bone, and related phenotypes are congenital hip dislocation and acetabular dysplasia

Related Diseases for Developmental Dysplasia of the Hip 1

Graphical network of the top 20 diseases related to Developmental Dysplasia of the Hip 1:



Diseases related to Developmental Dysplasia of the Hip 1

Symptoms & Phenotypes for Developmental Dysplasia of the Hip 1

Symptoms via clinical synopsis from OMIM:

57
Skeletal Pelvis:
congenital hip dislocation
positive ortolani sign


Clinical features from OMIM:

142700

Human phenotypes related to Developmental Dysplasia of the Hip 1:

32
# Description HPO Frequency HPO Source Accession
1 congenital hip dislocation 32 HP:0001374
2 acetabular dysplasia 32 HP:0008807

Drugs & Therapeutics for Developmental Dysplasia of the Hip 1

Search Clinical Trials , NIH Clinical Center for Developmental Dysplasia of the Hip 1

Genetic Tests for Developmental Dysplasia of the Hip 1

Genetic tests related to Developmental Dysplasia of the Hip 1:

# Genetic test Affiliating Genes
1 Acetabular Dysplasia 29

Anatomical Context for Developmental Dysplasia of the Hip 1

MalaCards organs/tissues related to Developmental Dysplasia of the Hip 1:

41
Bone

Publications for Developmental Dysplasia of the Hip 1

Articles related to Developmental Dysplasia of the Hip 1:

(show top 50) (show all 244)
# Title Authors Year
1
Graf Type-IV Hips Have a Higher Risk of Residual Acetabular Dysplasia at 1 Year of Age Following Successful Pavlik Harness Treatment for Developmental Hip Dysplasia. ( 27662383 )
2018
2
Acetabular index is the best predictor of late residual acetabular dysplasia after closed reduction in developmental dysplasia of the hip. ( 29285666 )
2018
3
Anterior and lateral overcoverage after triple pelvic osteotomy in childhood for developmental dislocation of the hip with acetabular dysplasia: Frequency, features, and medium-term clinical impact. ( 29474949 )
2018
4
Arthroscopic Treatment of Iliopsoas Snapping in Patients With Radiographic Acetabular Dysplasia Using Iliopsoas Fractional Lengthening and Capsular Plication. ( 29653792 )
2018
5
Comparison of four parameters to assess acetabular dysplasia and acetabular dysplasia rates in primary hip osteoarthritis patients: A study in Turkish population. ( 29669444 )
2018
6
Does Severity of Acetabular Dysplasia Influence Clinical Outcomes After Periacetabular Osteotomy?-A Case-Control Study. ( 29724578 )
2018
7
Prevalence and morphological features of acetabular dysplasia with coexisting femoroacetabular impingement-related findings in a Japanese population: a computed tomography-based cross-sectional study. ( 29876130 )
2018
8
Analysis of Femoral Version in Patients Undergoing Periacetabular Osteotomy for Symptomatic Acetabular Dysplasia. ( 29877918 )
2018
9
Joint contact stresses calculated for acetabular dysplasia patients using discrete element analysis are significantly influenced by the applied gait pattern. ( 30104055 )
2018
10
Modified triple pelvic osteotomy for adult symptomatic acetabular dysplasia: clinical and radiographic results at midterm follow-up. ( 30219063 )
2018
11
Comparison of 3 Pediatric Pelvic Osteotomies for Acetabular Dysplasia Using Patient-specific 3D-printed Models. ( 30300278 )
2018
12
Trends of hip arthroscopy in the setting of acetabular dysplasia. ( 30393554 )
2018
13
Ten- and 20-year Survivorship of the Hip After Periacetabular Osteotomy for Acetabular Dysplasia. ( 30433888 )
2018
14
Tönnis triple pelvic osteotomy for the management of late residual acetabular dysplasia: mid-term to long-term follow-up study of 54 patients. ( 30489443 )
2018
15
Three Patterns of Acetabular Deficiency Are Common in Young Adult Patients With Acetabular Dysplasia. ( 27830486 )
2017
16
The Iliofemoral Line: A Radiographic Sign of Acetabular Dysplasia in the Adult Hip. ( 28609639 )
2017
17
Rotational acetabular osteotomy for acetabular dysplasia and osteoarthritis: a mean follow-up of 20A years. ( 28197751 )
2017
18
Patient-specific chondrolabral contact mechanics in patients with acetabular dysplasia following treatment with peri-acetabular osteotomy. ( 27923602 )
2017
19
The Utility of False-Profile Radiographs for the Detection of Osteoarthritis Progression in Acetabular Dysplasia. ( 30229227 )
2017
20
The management of residual acetabular dysplasia: updates and controversies. ( 27379671 )
2017
21
Editorial: Cam Deformity and Acetabular Dysplasia as Risk Factors for Hip Osteoarthritis. ( 27635595 )
2017
22
Cam Deformity and Acetabular Dysplasia as Risk Factors for Hip Osteoarthritis. ( 27696746 )
2017
23
Descriptive Epidemiology of Acetabular Dysplasia: The Academic Network of Conservational Hip Outcomes Research (ANCHOR) Periacetabular Osteotomy. ( 28098707 )
2017
24
Multiplanar evaluation of radiological findings associated with acetabular dysplasia and investigation of its prevalence in an Asian population: a CT-based study. ( 28137249 )
2017
25
Osteoarthritis of the hip joint in elderly patients is most commonly atrophic, with low parameters of acetabular dysplasia and possible involvement of osteoporosis. ( 28332125 )
2017
26
A Contemporary Definition of Hip Dysplasia and Structural Instability: Toward a Comprehensive Classification for Acetabular Dysplasia. ( 28389135 )
2017
27
Functional status and amount of hip displacement independently affect acetabular dysplasia in cerebral palsy. ( 28432692 )
2017
28
Acetabular dysplasia: multiple pathologies and myriad solutions. ( 28566387 )
2017
29
The Birmingham Interlocking Pelvic Osteotomy for acetabular dysplasia: 13- to 21-year survival outcomes. ( 28566390 )
2017
30
Early Functional Outcomes of Periacetabular Osteotomy After Failed Hip Arthroscopic Surgery for Symptomatic Acetabular Dysplasia. ( 28617619 )
2017
31
Copy number loss in the region of the ASPN gene in patients with acetabular dysplasia: ASPN CNV in acetabular dysplasia. ( 28747338 )
2017
32
Incidence of acetabular dysplasia in breech infants following initially normal ultrasound: the effect of variable diagnostic criteria. ( 28904632 )
2017
33
Multiple epiphyseal dysplasia mimicking osteoarthritis due to acetabular dysplasia: A report of a familial case with a COMP mutation. ( 26920793 )
2016
34
The Occurrence of Occult Acetabular Dysplasia in Relatives of Individuals With Developmental Dysplasia of the Hip. ( 25705807 )
2016
35
Acetabuloplasties at Open Reduction Prevent Acetabular Dysplasia in Intentionally Delayed Developmental Dysplasia of the Hip: A Case-control Study. ( 26272657 )
2016
36
Acetabular dysplasia may be related to global joint hyperlaxity. ( 26419956 )
2016
37
Acetabular Dysplasia and Surgical Approaches Other Than Direct Anterior Increases Risk for Malpositioning of the Acetabular Component in Total Hip Arthroplasty. ( 26706838 )
2016
38
How Often Does Femoroacetabular Impingement Occur After an Innominate Osteotomy for Acetabular Dysplasia? ( 26822844 )
2016
39
Computer-Assisted Rotational Acetabular Osteotomy for Patients with Acetabular Dysplasia. ( 26929806 )
2016
40
Return to Play After Periacetabular Osteotomy for Treatment of Acetabular Dysplasia in Adolescent and Young Adult Athletes. ( 26969123 )
2016
41
Preoperative prognosis score is a useful tool regarding eccentric rotational acetabular osteotomy in patients with acetabular dysplasia. ( 27012377 )
2016
42
Acetabular Dysplasia in Middle-Aged Patients: Periacetabular Osteotomy or Total Hip Arthroplasty? ( 27017199 )
2016
43
Femoral Morphology in Patients Undergoing Periacetabular Osteotomy for Classic or Borderline Acetabular Dysplasia: Are Cam Deformities Common? ( 27067756 )
2016
44
Double-Level Pelvic Osteotomy for Managing Persistent Acetabular Dysplasia. ( 27203413 )
2016
45
Do labral tears influence poor outcomes after periacetabular osteotomy for acetabular dysplasia? ( 27235514 )
2016
46
Femoral Deformity May Be More Predictive of Hip Range of Motion Than Severity of Acetabular Disease in Patients With Acetabular Dysplasia: An Analysis of the ANCHOR Cohort. ( 27314923 )
2016
47
Patient Characteristics and Early Functional Outcomes of Combined Arthroscopic Labral Refixation and Periacetabular Osteotomy for Symptomatic Acetabular Dysplasia. ( 27416990 )
2016
48
Factors associated with diagnostic stage of hip osteoarthritis due to acetabular dysplasia among Japanese female patients: a cross-sectional study. ( 27484820 )
2016
49
A pre-operative predictive score for the outcome of eccentric rotational acetabular osteotomy in the treatment of acetabular dysplasia and early osteoarthritis of the hip in adults. ( 27694585 )
2016
50
Triple pelvic osteotomy for the treatment of symptomatic acetabular dysplasia in adolescents and adults : A review of 42 hips. ( 29182108 )
2016

Variations for Developmental Dysplasia of the Hip 1

Expression for Developmental Dysplasia of the Hip 1

Search GEO for disease gene expression data for Developmental Dysplasia of the Hip 1.

Pathways for Developmental Dysplasia of the Hip 1

GO Terms for Developmental Dysplasia of the Hip 1

Sources for Developmental Dysplasia of the Hip 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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