MCID: DXT001
MIFTS: 55

Dextrocardia

Categories: Cardiovascular diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Dextrocardia

MalaCards integrated aliases for Dextrocardia:

Name: Dextrocardia 12 74 52 58 29 6 43 15 32
Heart Predominantly in Right Hemithorax 12

Classifications:

Orphanet: 58  
Rare cardiac malformations
Developmental anomalies during embryogenesis


External Ids:

Disease Ontology 12 DOID:9565
MeSH 43 D003914
NCIt 49 C84669
SNOMED-CT 67 27637000
ICD10 32 Q24.0
MESH via Orphanet 44 D003914
ICD10 via Orphanet 33 Q24.0
UMLS via Orphanet 72 C0011813 C0265863
Orphanet 58 ORPHA1666
UMLS 71 C0011813

Summaries for Dextrocardia

NIH Rare Diseases : 52 Dextrocardia is a condition in which the heart is located in the right side of the chest instead of the left. It is usually present from birth (congenital ). There are several types of dextrocardia. The simplest type occurs when the shape and structure of the heart is a mirror image of a normal heart. Other types of dextrocardia may involve defects of the walls of the heart, nearby blood vessels, or other organs in the abdomen. Chest X-raxys and echocardiograms can be used to determine which type of dextrocardia is present.

MalaCards based summary : Dextrocardia, also known as heart predominantly in right hemithorax, is related to dextrocardia with situs inversus and ciliary dyskinesia, primary, 1. An important gene associated with Dextrocardia is DNAI1 (Dynein Axonemal Intermediate Chain 1), and among its related pathways/superpathways are Mesodermal Commitment Pathway and Signaling pathways regulating pluripotency of stem cells. The drugs Spironolactone and Mineralocorticoid Receptor Antagonists have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and liver, and related phenotypes are t-wave inversion and situs inversus totalis

Wikipedia : 74 Dextrocardia (from Latin dexter, meaning "right," and Greek kardia, meaning "heart") is a rare... more...

Related Diseases for Dextrocardia

Diseases related to Dextrocardia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 265)
# Related Disease Score Top Affiliating Genes
1 dextrocardia with situs inversus 34.4 NODAL HES7 CFAP53
2 ciliary dyskinesia, primary, 1 31.6 DNAI1 DNAH5 DNAH11 CCDC40 CCDC151 ARMC4
3 kartagener syndrome 31.4 ZIC3 DNAI1 DNAH5 DNAH11 CFAP53 CCDC40
4 heart septal defect 31.1 ZIC3 NODAL ACTC1
5 heterotaxy 30.6 ZIC3 NODAL CFAP53 ACVR2B
6 atrial heart septal defect 30.5 ZIC3 NODAL MYH7 ACTC1
7 ventricular septal defect 30.3 ZIC3 NODAL MYH7
8 situs inversus 30.3 DNAI1 DNAH5 DNAH11 CFAP53 CCDC40 CCDC151
9 tetralogy of fallot 30.2 ZIC3 STRA6 RAI2 NODAL ACTC1
10 dextro-looped transposition of the great arteries 30.1 ZIC3 NODAL DNAI1 DNAH5 DNAH11 ARMC4
11 tricuspid atresia 30.1 ZIC3 MT-ND1
12 bronchiectasis 30.0 DNAI1 DNAH5 DNAH11 CCDC40
13 total anomalous pulmonary venous return 1 30.0 ZIC3 NODAL
14 hypoplastic left heart syndrome 29.8 ZIC3 NODAL CFAP53
15 right atrial isomerism 29.3 ZIC3 NODAL DNAI1 DNAH5 DNAH11 ACVR2B
16 visceral heterotaxy 28.2 ZIC3 NODAL DNAI1 DNAH5 DNAH11 CFAP53
17 primary ciliary dyskinesia 28.0 ZIC3 NODAL DNAI1 DNAH5 DNAH11 CFAP53
18 dextrocardia with unusual facies and microphthalmia 12.4
19 stratton-parker syndrome 12.1
20 heterotaxy, visceral, 1, x-linked 12.1
21 poland syndrome 11.5
22 levocardia 11.5
23 heterotaxy, visceral, 5, autosomal 11.5
24 pagod syndrome 11.4
25 carpenter syndrome 1 11.2
26 marden-walker syndrome 11.2
27 heterotaxy, visceral, 4, autosomal 11.2
28 intellectual disability - athetosis - microphthalmia 11.2
29 double discordia 10.6
30 myocardial infarction 10.5
31 mitral valve insufficiency 10.4
32 right aortic arch 10.4 CFAP53 ACVR2B
33 double outlet right ventricle 10.4
34 acute myocardial infarction 10.4
35 osteogenesis imperfecta, type xi 10.4 DNAI1 ARMC4
36 mitral valve stenosis 10.3
37 hyperlipoproteinemia, type iii 10.3
38 lipoprotein quantitative trait locus 10.3
39 congenitally corrected transposition of the great arteries 10.3
40 progressive familial heart block, type ia 10.3
41 single ventricular heart 10.3
42 pulmonary hypertension 10.3
43 atrial fibrillation 10.3
44 congestive heart failure 10.3
45 arteries, anomalies of 10.2
46 pulmonary hypoplasia, primary 10.2
47 tricuspid valve insufficiency 10.2
48 cyanosis, transient neonatal 10.2
49 heart disease 10.2
50 sick sinus syndrome 10.2

Graphical network of the top 20 diseases related to Dextrocardia:



Diseases related to Dextrocardia

Symptoms & Phenotypes for Dextrocardia

Human phenotypes related to Dextrocardia:

58 31 (show all 27)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 t-wave inversion 58 31 hallmark (90%) Very frequent (99-80%) HP:0010872
2 situs inversus totalis 58 31 frequent (33%) Frequent (79-30%) HP:0001696
3 congenital malformation of the great arteries 58 31 frequent (33%) Frequent (79-30%) HP:0011603
4 intestinal malrotation 58 31 occasional (7.5%) Occasional (29-5%) HP:0002566
5 abnormality of the ureter 58 31 occasional (7.5%) Occasional (29-5%) HP:0000069
6 abnormality of the spleen 58 31 occasional (7.5%) Occasional (29-5%) HP:0001743
7 abnormality of the pulmonary artery 58 31 occasional (7.5%) Occasional (29-5%) HP:0004414
8 abnormal lung lobation 58 31 occasional (7.5%) Occasional (29-5%) HP:0002101
9 abnormal renal morphology 58 31 occasional (7.5%) Occasional (29-5%) HP:0012210
10 abnormal reproductive system morphology 58 31 occasional (7.5%) Occasional (29-5%) HP:0012243
11 abnormality of abdominal situs 58 31 occasional (7.5%) Occasional (29-5%) HP:0011620
12 abnormal pulmonary situs morphology 31 occasional (7.5%) HP:0011615
13 global developmental delay 58 31 very rare (1%) Very rare (<4-1%) HP:0001263
14 hydrocephalus 58 31 very rare (1%) Very rare (<4-1%) HP:0000238
15 webbed neck 58 31 very rare (1%) Very rare (<4-1%) HP:0000465
16 congenital hip dislocation 58 31 very rare (1%) Very rare (<4-1%) HP:0001374
17 preauricular skin tag 58 31 very rare (1%) Very rare (<4-1%) HP:0000384
18 abnormality of the ribs 58 31 very rare (1%) Very rare (<4-1%) HP:0000772
19 abnormality of the foot 58 31 very rare (1%) Very rare (<4-1%) HP:0001760
20 neuroblastoma 58 31 very rare (1%) Very rare (<4-1%) HP:0003006
21 meckel diverticulum 58 31 very rare (1%) Very rare (<4-1%) HP:0002245
22 pancreatic hypoplasia 58 31 very rare (1%) Very rare (<4-1%) HP:0002594
23 aplasia/hypoplasia of the ear 58 31 very rare (1%) Very rare (<4-1%) HP:0008771
24 dextrocardia 58 Obligate (100%)
25 abnormal heart morphology 58 Very frequent (99-80%)
26 abnormal ekg 58 Very frequent (99-80%)
27 abnormality of pulmonary situs 58 Occasional (29-5%)

MGI Mouse Phenotypes related to Dextrocardia:

45 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.34 ACTC1 ACVR2B ARMC4 CCDC151 CFAP53 DNAH11
2 growth/size/body region MP:0005378 10.33 ACTC1 ACVR2B ARMC4 CCDC151 CCDC40 CFAP53
3 cellular MP:0005384 10.32 ACTC1 ACVR2B ARMC4 CCDC151 CCDC40 CFAP53
4 mortality/aging MP:0010768 10.22 ACTC1 ACVR2B ARMC4 CCDC151 CCDC40 CFAP53
5 immune system MP:0005387 10.18 ACVR2B ARMC4 CCDC151 CFAP53 CTC1 DNAH11
6 hematopoietic system MP:0005397 10.17 ACVR2B ARMC4 CCDC151 CFAP53 CTC1 DNAH11
7 embryo MP:0005380 10.13 ACVR2B CCDC40 CFAP53 DNAH11 HES7 NODAL
8 craniofacial MP:0005382 10.04 CCDC151 DNAH11 DNAH5 DNAI1 NODAL STRA6
9 nervous system MP:0003631 9.93 ACTC1 ARMC4 CCDC151 CCDC40 CFAP53 CTC1
10 liver/biliary system MP:0005370 9.91 ACVR2B CCDC151 CFAP53 DNAH11 DNAH5 NODAL
11 muscle MP:0005369 9.8 ACTC1 ACVR2B ARMC4 DNAH11 MYH7 NODAL
12 respiratory system MP:0005388 9.65 ACVR2B ARMC4 CCDC151 CCDC40 CFAP53 DNAH11
13 skeleton MP:0005390 9.28 ACVR2B CCDC151 DNAH11 DNAH5 DNAI1 HES7

Drugs & Therapeutics for Dextrocardia

Drugs for Dextrocardia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Spironolactone Approved Phase 4 52-01-7, 1952-01-7 5833
2 Mineralocorticoid Receptor Antagonists Phase 4
3 Hormone Antagonists Phase 4
4 Hormones Phase 4
5 Mineralocorticoids Phase 4
6 Natriuretic Peptide, Brain Phase 4
7 diuretics Phase 4
8 Diuretics, Potassium Sparing Phase 4
9
Ambrisentan Approved, Investigational Phase 2 177036-94-1 6918493
10
Simendan Investigational Phase 2 131741-08-7
11 Antihypertensive Agents Phase 2
12 Cardiotonic Agents Phase 2
13 Phosphodiesterase Inhibitors Phase 2
14 Pharmaceutical Solutions Phase 2
15 Phosphodiesterase 3 Inhibitors Phase 2
16 Protective Agents Phase 2
17 Liver Extracts
18 Phosphodiesterase 5 Inhibitors
19 Respiratory System Agents
20 Vasodilator Agents

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Water Immersion in Right-Sided Heart Failure: A Pilot Study Completed NCT00654264 Phase 4
2 Spironolactone Therapy in Chronic Stable Right HF Trial Suspended NCT03344159 Phase 4 Spironolactone;Placebo
3 Safety, Pharmacokinetics (PK) and Hemodynamic Effects of Ambrisentan in Single Ventricle Pediatric Patients Completed NCT02080637 Phase 2 Ambrisentan
4 Open-Label Rollover Study of Levosimendan in Patients With Pulmonary Hypertension With Heart Failure and Preserved Left Ventricular Ejection Fraction (PH-HFpEF) Active, not recruiting NCT03624010 Phase 2 Levosimendan 2.5 mg/ml Injectable Solution
5 Severe and Transient Hypoxemia During Selective Intra-arterial Chemotherapy for Retinoblastoma in Children: Evaluation of the Right-sided Heart Function. Unknown status NCT03559894
6 Non-invasive Assessment of Liver Stiffness/Fibrosis by Transient Elastography (Fibroscan) in Patients With Left and/or Right Sided Heart Failure Completed NCT00777725
7 Evaluation of Multimodal Monitoring Technologies in the Peri-operative Care of Cardiac Surgical Patients Completed NCT02658006
8 Assessment of Portal Flow Using Bedside Doppler Ultrasonography for the Detection of Portal Pulsatility as a Risk Factor for Acute Kidney Injury in Cardiac Surgery Patients Completed NCT02831907
9 Transcatheter Valve Implantation in Patients With Dysfunctional Left and Right Sided Heart Valves Completed NCT02119442
10 Molecular Genetics of Heterotaxy and Related Congenital Heart Defects Recruiting NCT02432079
11 Right Ventricular Function After Withdrawal of Phosphodiesterase-5 Inhibitors in Left Ventricular Assist Device Recipients Recruiting NCT04117659
12 Open Lung Strategy in Critically Ill Morbid Obese Patients Lung Imaging and Heart-lung Interaction Active, not recruiting NCT02503241
13 Cardiac Metabolic Remodeling After Pulmonary Vasodilator Therapy in Pulmonary Arterial Hypertension: A Pilot Study Suspended NCT04090866

Search NIH Clinical Center for Dextrocardia

Cochrane evidence based reviews: dextrocardia

Genetic Tests for Dextrocardia

Genetic tests related to Dextrocardia:

# Genetic test Affiliating Genes
1 Dextrocardia 29

Anatomical Context for Dextrocardia

MalaCards organs/tissues related to Dextrocardia:

40
Heart, Lung, Liver, Kidney, Spleen, Brain, Skin

Publications for Dextrocardia

Articles related to Dextrocardia:

(show top 50) (show all 1397)
# Title Authors PMID Year
1
Percutaneous coronary intervention for left main coronary artery stenosis in a patient with dextrocardia. 61
31087254 2020
2
Dextrocardia, situs solitus, inlet ventricular septal defect (VSD), and iatrogenic tricuspid regurgitation (TR)-A surgical perspective. 61
32349171 2020
3
Right Lung Agenesis Associated with Dextrocardia and Pulmonary Hypertension. 61
31300255 2020
4
ST-Elevation Myocardial Infarction in a Patient Having Dextrocardia with Situs Inversus. 61
32359913 2020
5
Adverse impact of univentricular pacing for the patient with functional single ventricle: successful conversion to cardiac resynchronization therapy. 61
32405970 2020
6
A new case with Hermansky-Pudlak syndrome type 9, a rare cause of syndromic albinism with severe defect of platelets dense bodies. 61
32245340 2020
7
Successful Multi-vessel Percutaneous Coronary Intervention for Recent Myocardial Infarction in a Patient with Dextrocardia and Situs Inversus. 61
32506107 2020
8
Feasibility of novel transapical off pump beating heart mitral valve repair in a patient with dextrocardia and situs inversus. 61
32155238 2020
9
Exome-Based Case-Control Analysis Highlights the Pathogenic Role of Ciliary Genes in Transposition of the Great Arteries. 61
32078439 2020
10
Stress cardiomyopathy in dextrocardia with situs inversus and anomalous coronary arteries. 61
32131905 2020
11
Scoliosis Curvature Follows Thoracic Organ Orientation. 61
29952884 2020
12
Tetralogy of Fallot With Dextrocardia and Anomalous Coronary Artery: A Case Report. 61
32195621 2020
13
Recurrent Peumonia in an Infant With an Esophageal Lung. 61
32198873 2020
14
Heart transplantation for dextrocardia: preoperative planning using 3D printing. 61
31620774 2020
15
Late Presentation of a Congenitally Corrected Transposition of Great Arteries and Hemodynamically Balanced Ventricles Associated with a Large Ventricular Septal Defect and Severe Pulmonary Stenosis: A Case Report and a Multi-Imaging Approach. 61
32111814 2020
16
Intraoperative Transesophageal Echocardiography in a Rare Case of Dextrocardia, Situs Inversus Totalis, and Double-Outlet Right Ventricle. 61
31850907 2020
17
Transseptal Approach for Mitral Valve Replacement in Dextrocardia with Situs Inversus Totalis: A Case Report and Review of the Literature. 61
32118539 2020
18
Acute total occlusion of left circumflex artery in a patient with dextrocardia and situs inversus. 61
31939325 2020
19
Anesthesia During Functional Endoscopic Sinus Surgery for Kartagener's Syndrome: A Case Report and Literature Review. 61
32431532 2020
20
HotBalloon ablation of atrial fibrillation in patients with dextrocardia and situs inversus by "mirror image" approach. 61
31844479 2019
21
Jarvik 2000 axial flow ventricular assist device in right single ventricle after Fontan operation. 61
31392523 2019
22
Ischemic mitral regurgitation in a patient with dextrocardia and situs inversus totalis. 61
31768245 2019
23
Deterioration of chest wall depression causing congestive hepatopathy after an open thoracostomy window in a patient with pectus excavatum and tuberculosis empyema. 61
31679134 2019
24
Isthmic Aortic False Aneurysm Post-Patch Coarctation Aortoplasty: A Hybrid Solution. 61
31376546 2019
25
Effective alcohol septal ablation for left ventricular outflow tract obstruction in a patient with isolated dextrocardia. 61
31780619 2019
26
Permanent His-bundle pacing for dextrocardia with situs inversus totalis using a combination of an electrode catheter and a deflectable sheath. 61
31890571 2019
27
Thoracoscopic segmentectomy assisted by three-dimensional computed tomography bronchography and angiography for lung cancer in a patient living with situs inversus totalis: A case report. 61
31799313 2019
28
STEMI in a patient with mirror-image dextrocardia. 61
31567739 2019
29
Percutaneous closure of ostium secundum atrial septal defect using left internal jugular vein access in a child with situs inversus and absence of inferior caval vein. 61
31475660 2019
30
Successful cryoballoon ablation of a focal atrial tachycardia in a patient with situs inversus and dextrocardia. 61
31624605 2019
31
Management of a young patient with dextrocardia, atrial septal defect, and Eisenmenger syndrome with venous-venous extracorporeal membrane oxygenation and heart-lung transplantation. 61
31332841 2019
32
Prolonged sustained ventricular fibrillation in a patient with dextrocardia and a left ventricular assist device. 61
31389822 2019
33
Multicenter Experience of Subcutaneous Implantable Cardioverter-Defibrillator Therapy in Patients With Dextrocardia. 61
31648749 2019
34
Surgical ductal stent implantation in total anomalous pulmonary venous connection to vena porta with right pulmonary sequestration in a mature newborn. 61
31360457 2019
35
Redo robotic cardiac surgery and concomitant cesarean section in a pregnant patient with dextrocardia and situs inversus totalis. 61
31233237 2019
36
[Mitral Valve and Tricuspid Valve Regurgitation in a Patient with Dextrocardia and Absence of the Inferior Vena Cava]. 61
31353349 2019
37
Case Reports of Situs Inversus Totalis and Dextrocardia in Sprague Dawley Rats. 61
31443162 2019
38
Interstitial 5p15.2-p13.3 deletion in association with situs inversus, dextrocardia, L-loop of the ventricles, and transposition of great arteries in a newborn infant. 61
31331405 2019
39
Successful high-density mapping and ablation of atrial tachycardia in a patient with dextrocardia and situs inversus: a complex case. 61
31400210 2019
40
Situs Inversus: Inferior-Lateral ST-Elevation Myocardial Infarction on Right-Sided Electrocardiogram. 61
31404172 2019
41
[A Total Right Heart Bypass Operation for Polysplenia with Unilateral Pulmonary Arteriovenous Fistula;the Usefulness of the Anastomosis of the Hepatic Vein to the Azygous Vein Combined with Dilatable Pulmonary Artery Banding]. 61
31353348 2019
42
L-looped Transposition of the Great Arteries in a Patient with Marfanoid Habitus: First Reported Case in Literature. 61
31632869 2019
43
SPECT myocardial perfusion imaging in patients with Dextrocardia. 61
31062220 2019
44
Coronary angioplasty in an adult with dextrocardia and single coronary artery with the right coronary artery originating from the left anterior descending artery. 61
30707111 2019
45
Implantation of a Dual-Chamber Pacemaker in a Patient with Situs Inversus and Dextrocardia using a Novel Ultrasound Technique. 61
31728305 2019
46
Atrial Septal Defect Size and Rims on Transesophageal Echocardiogram. 61
31523285 2019
47
Computed Tomography Angiography and Magnetic Resonance Angiography of Congenital Anomalies of Pulmonary Veins. 61
31082945 2019
48
Computed Tomography Angiography and Magnetic Resonance Angiography of Congenital Anomalies of Pulmonary Veins. 61
31082974 2019
49
3D Printing to Model Surgical Repair of Complex Congenitally Corrected Transposition of the Great Arteries. 61
28825385 2019
50
Persistent dextrocardia after adult orthotopic heart transplantation in a patient with complex congenital heart disease. 61
30528511 2019

Variations for Dextrocardia

ClinVar genetic disease variations for Dextrocardia:

6 ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 CFAP53 NM_145020.5(CFAP53):c.301_473+1deldeletion Likely pathogenic 488411 rs1555672928 18:47787433-47787606 18:50261063-50261236
2 CFAP53 NM_145020.5(CFAP53):c.472A>G (p.Arg158Gly)SNV Likely pathogenic 217132 rs886037751 18:47787435-47787435 18:50261065-50261065
3 ROCK2 NM_004850.5(ROCK2):c.3724C>T (p.Gln1242Ter)SNV Uncertain significance 545556 rs1558277937 2:11332802-11332802 2:11192676-11192676
4 ZFYVE16 NM_001284236.3(ZFYVE16):c.1798G>A (p.Asp600Asn)SNV Uncertain significance 545559 rs1561277007 5:79734302-79734302 5:80438483-80438483
5 ZFYVE16 NM_001284236.3(ZFYVE16):c.3755G>C (p.Gly1252Ala)SNV Uncertain significance 545560 rs1561310640 5:79752344-79752344 5:80456525-80456525
6 RAI2 NM_021785.5(RAI2):c.712G>A (p.Val238Ile)SNV Uncertain significance 545561 rs1208705303 X:17819419-17819419 X:17801299-17801299
7 SUPT16H NM_007192.4(SUPT16H):c.956-1G>ASNV Uncertain significance 545562 rs1566388186 14:21834689-21834689 14:21366530-21366530

Expression for Dextrocardia

Search GEO for disease gene expression data for Dextrocardia.

Pathways for Dextrocardia

Pathways related to Dextrocardia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.74 ZIC3 NODAL HES7 ACVR2B
2 11.49 ZIC3 NODAL ACVR2B
3 10.77 ZFYVE16 NODAL ACVR2B

GO Terms for Dextrocardia

Cellular components related to Dextrocardia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoskeleton GO:0005856 9.95 ROCK2 DNAI1 DNAH5 DNAH11 CCDC151 ARMC4
2 cell projection GO:0042995 9.87 DNAI1 DNAH5 DNAH11 CFAP53 CCDC40 CCDC151
3 outer dynein arm GO:0036157 9.37 DNAI1 DNAH5
4 axoneme GO:0005930 9.35 DNAH5 DNAH11 CCDC40 CCDC151 ARMC4
5 dynein complex GO:0030286 9.33 DNAI1 DNAH5 DNAH11
6 9+2 motile cilium GO:0097729 9.26 DNAH5 DNAH11
7 cilium GO:0005929 9.17 DNAI1 DNAH5 DNAH11 CFAP53 CCDC40 CCDC151

Biological processes related to Dextrocardia according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 anterior/posterior pattern specification GO:0009952 9.8 ZIC3 NODAL HES7 ACVR2B
2 lung development GO:0030324 9.8 ZIC3 STRA6 NODAL CCDC40 ACVR2B
3 flagellated sperm motility GO:0030317 9.76 DNAI1 DNAH5 DNAH11 CCDC40
4 BMP signaling pathway GO:0030509 9.75 ZFYVE16 NODAL ACVR2B
5 microtubule-based movement GO:0007018 9.74 DNAI1 DNAH5 DNAH11
6 heart looping GO:0001947 9.73 ZIC3 NODAL CCDC40
7 heart development GO:0007507 9.7 STRA6 NODAL DNAI1 DNAH5 DNAH11 ARMC4
8 epithelial cilium movement GO:0003351 9.62 DNAI1 DNAH5 DNAH11 CCDC40
9 epithelial cilium movement involved in determination of left/right asymmetry GO:0060287 9.61 DNAH11 CFAP53 CCDC40
10 gastrulation with mouth forming second GO:0001702 9.6 NODAL ACVR2B
11 digestive tract morphogenesis GO:0048546 9.59 STRA6 NODAL
12 axonemal dynein complex assembly GO:0070286 9.58 CCDC40 CCDC151
13 outer dynein arm assembly GO:0036158 9.56 DNAI1 DNAH5 CCDC151 ARMC4
14 positive regulation of activin receptor signaling pathway GO:0032927 9.55 NODAL ACVR2B
15 determination of liver left/right asymmetry GO:0071910 9.54 ZIC3 CCDC40
16 regulation of cilium beat frequency GO:0003356 9.54 DNAH11 CCDC40 ARMC4
17 determination of digestive tract left/right asymmetry GO:0071907 9.52 ZIC3 CCDC40
18 determination of pancreatic left/right asymmetry GO:0035469 9.51 ZIC3 CCDC40
19 cilium movement GO:0003341 9.5 DNAI1 DNAH5 DNAH11 CFAP53 CCDC40 CCDC151
20 determination of left/right asymmetry in nervous system GO:0035545 9.48 ZIC3 DNAH11
21 determination of left/right symmetry GO:0007368 9.28 ZIC3 NODAL DNAI1 DNAH5 DNAH11 CFAP53

Molecular functions related to Dextrocardia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATP-dependent microtubule motor activity, minus-end-directed GO:0008569 8.96 DNAH5 DNAH11
2 motor activity GO:0003774 8.92 MYH7 DNAI1 DNAH5 DNAH11

Sources for Dextrocardia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....