MCID: DXT001
MIFTS: 55

Dextrocardia

Categories: Cardiovascular diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Dextrocardia

MalaCards integrated aliases for Dextrocardia:

Name: Dextrocardia 12 74 20 58 29 6 44 15 32
Heart Predominantly in Right Hemithorax 12

Classifications:

Orphanet: 58  
Rare cardiac malformations
Developmental anomalies during embryogenesis


External Ids:

Disease Ontology 12 DOID:9565
MeSH 44 D003914
NCIt 50 C84669
SNOMED-CT 67 27637000
ICD10 32 Q24.0
MESH via Orphanet 45 D003914
ICD10 via Orphanet 33 Q24.0
UMLS via Orphanet 72 C0011813 C0265863
Orphanet 58 ORPHA1666
UMLS 71 C0011813

Summaries for Dextrocardia

GARD : 20 Dextrocardia is a condition in which the heart is located in the right side of the chest instead of the left. It is usually present from birth (congenital). There are several types of dextrocardia. The simplest type occurs when the shape and structure of the heart is a mirror image of a normal heart. Other types of dextrocardia may involve defects of the walls of the heart, nearby blood vessels, or other organs in the abdomen. Chest X-raxys and echocardiograms can be used to determine which type of dextrocardia is present.

MalaCards based summary : Dextrocardia, also known as heart predominantly in right hemithorax, is related to dextrocardia with situs inversus and heart septal defect. An important gene associated with Dextrocardia is CFAP53 (Cilia And Flagella Associated Protein 53), and among its related pathways/superpathways are Mesodermal Commitment Pathway and Signaling pathways regulating pluripotency of stem cells. The drugs Spironolactone and Hormone Antagonists have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and spleen, and related phenotypes are t-wave inversion and situs inversus totalis

Wikipedia : 74 Dextrocardia (from Latin dexter, meaning "right," and Greek kardia, meaning "heart") is a rare... more...

Related Diseases for Dextrocardia

Diseases related to Dextrocardia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 265)
# Related Disease Score Top Affiliating Genes
1 dextrocardia with situs inversus 32.6 NODAL HES7 CFAP53
2 heart septal defect 31.1 ZIC3 NODAL ACTC1
3 ciliary dyskinesia, primary, 1 30.9 ODAD3 ODAD2 DNAI1 DNAH5 DNAH11
4 situs inversus 30.8 ODAD3 DNAI1 DNAH5 DNAH11 CFAP53
5 kartagener syndrome 30.7 ZIC3 ODAD3 ODAD2 DNAI1 DNAH5 DNAH11
6 double outlet right ventricle 30.6 ZIC3 NODAL ACVR2B
7 atrial heart septal defect 30.5 ZIC3 NODAL MYH7 ACTC1
8 heterotaxy 30.5 ZIC3 NODAL CFAP53 ACVR2B
9 tetralogy of fallot 30.2 ZIC3 STRA6 RAI2 NODAL ACTC1
10 wolff-parkinson-white syndrome 30.2 NODAL MYH7 ACTC1
11 bronchiectasis 30.1 DNAI1 DNAH5 DNAH11
12 total anomalous pulmonary venous return 1 30.0 ZIC3 NODAL MYRF
13 tricuspid atresia 30.0 ZIC3 MT-ND1
14 dextro-looped transposition of the great arteries 30.0 ZIC3 ODAD2 NODAL DNAI1 DNAH5 DNAH11
15 hypoplastic left heart syndrome 29.6 ZIC3 NODAL CFAP53
16 heart disease 29.3 ZIC3 NODAL MYH7 DNAI1 DNAH5 DNAH11
17 right atrial isomerism 29.2 ZIC3 NODAL DNAI1 DNAH5 DNAH11 ACVR2B
18 visceral heterotaxy 28.6 ZIC3 ODAD3 ODAD2 NODAL DNAI1 DNAH5
19 primary ciliary dyskinesia 28.4 ZIC3 ODAD3 ODAD2 NODAL DNAI1 DNAH5
20 stratton-parker syndrome 11.4
21 heterotaxy, visceral, 1, x-linked 11.3
22 dextrocardia with unusual facies and microphthalmia 11.2
23 pagod syndrome 11.2
24 poland syndrome 11.0
25 levocardia 11.0
26 heterotaxy, visceral, 5, autosomal 10.9
27 carpenter syndrome 1 10.9
28 marden-walker syndrome 10.9
29 heterotaxy, visceral, 4, autosomal 10.9
30 heterotaxy, visceral, 9, autosomal, with male infertility 10.9
31 intellectual disability - athetosis - microphthalmia 10.9
32 double discordia 10.5
33 ventricular septal defect 10.5
34 mitral valve insufficiency 10.3
35 myocardial infarction 10.3
36 right aortic arch 10.3 CFAP53 ACVR2B
37 acute myocardial infarction 10.3
38 mitral valve stenosis 10.2
39 congenitally corrected transposition of the great arteries 10.2
40 single ventricular heart 10.2
41 atrial fibrillation 10.2
42 progressive familial heart block, type ia 10.2
43 ebstein anomaly 10.2 NODAL MYH7 ACTC1
44 cyanosis, transient neonatal 10.1
45 arteries, anomalies of 10.1
46 pulmonary hypoplasia, primary 10.1
47 lipoprotein quantitative trait locus 10.1
48 pulmonary hypertension 10.1
49 sick sinus syndrome 10.1
50 tricuspid valve insufficiency 10.1

Graphical network of the top 20 diseases related to Dextrocardia:



Diseases related to Dextrocardia

Symptoms & Phenotypes for Dextrocardia

Human phenotypes related to Dextrocardia:

58 31 (show all 28)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 t-wave inversion 58 31 hallmark (90%) Very frequent (99-80%) HP:0010872
2 situs inversus totalis 58 31 frequent (33%) Frequent (79-30%) HP:0001696
3 congenital malformation of the great arteries 58 31 frequent (33%) Frequent (79-30%) HP:0011603
4 intestinal malrotation 58 31 occasional (7.5%) Occasional (29-5%) HP:0002566
5 abnormality of the ureter 58 31 occasional (7.5%) Occasional (29-5%) HP:0000069
6 abnormality of the spleen 58 31 occasional (7.5%) Occasional (29-5%) HP:0001743
7 abnormality of the pulmonary artery 58 31 occasional (7.5%) Occasional (29-5%) HP:0004414
8 abnormal lung lobation 58 31 occasional (7.5%) Occasional (29-5%) HP:0002101
9 abnormal renal morphology 58 31 occasional (7.5%) Occasional (29-5%) HP:0012210
10 abnormal reproductive system morphology 58 31 occasional (7.5%) Occasional (29-5%) HP:0012243
11 abnormality of abdominal situs 58 31 occasional (7.5%) Occasional (29-5%) HP:0011620
12 abnormal pulmonary situs morphology 31 occasional (7.5%) HP:0011615
13 hydrocephalus 58 31 very rare (1%) Very rare (<4-1%) HP:0000238
14 global developmental delay 58 31 very rare (1%) Very rare (<4-1%) HP:0001263
15 webbed neck 58 31 very rare (1%) Very rare (<4-1%) HP:0000465
16 congenital hip dislocation 58 31 very rare (1%) Very rare (<4-1%) HP:0001374
17 preauricular skin tag 58 31 very rare (1%) Very rare (<4-1%) HP:0000384
18 abnormality of the ribs 58 31 very rare (1%) Very rare (<4-1%) HP:0000772
19 neuroblastoma 58 31 very rare (1%) Very rare (<4-1%) HP:0003006
20 meckel diverticulum 58 31 very rare (1%) Very rare (<4-1%) HP:0002245
21 pancreatic hypoplasia 58 31 very rare (1%) Very rare (<4-1%) HP:0002594
22 aplasia/hypoplasia of the ear 58 31 very rare (1%) Very rare (<4-1%) HP:0008771
23 abnormal foot morphology 31 very rare (1%) HP:0001760
24 abnormality of the foot 58 Very rare (<4-1%)
25 dextrocardia 58 Obligate (100%)
26 abnormal heart morphology 58 Very frequent (99-80%)
27 abnormal ekg 58 Very frequent (99-80%)
28 abnormality of pulmonary situs 58 Occasional (29-5%)

MGI Mouse Phenotypes related to Dextrocardia:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.34 ACTC1 ACVR2B CFAP53 DNAH11 DNAH5 DNAI1
2 growth/size/body region MP:0005378 10.3 ACTC1 ACVR2B CFAP53 CTC1 DNAH11 DNAH5
3 cellular MP:0005384 10.29 ACTC1 ACVR2B CFAP53 CTC1 DNAH11 DNAH5
4 immune system MP:0005387 10.22 ACVR2B CFAP53 CTC1 DNAH11 DNAH5 DNAI1
5 mortality/aging MP:0010768 10.22 ACTC1 ACVR2B CFAP53 CTC1 DNAH11 DNAH5
6 hematopoietic system MP:0005397 10.21 ACTC1 ACVR2B CFAP53 CTC1 DNAH11 DNAH5
7 embryo MP:0005380 10.13 ACTC1 ACVR2B CFAP53 DNAH11 HES7 NODAL
8 craniofacial MP:0005382 10.1 ACTC1 DNAH11 DNAH5 DNAI1 NODAL ODAD3
9 nervous system MP:0003631 9.97 ACTC1 ACVR2B CFAP53 CTC1 DNAH5 DNAI1
10 liver/biliary system MP:0005370 9.91 ACVR2B CFAP53 DNAH11 DNAH5 NODAL ODAD3
11 muscle MP:0005369 9.8 ACTC1 ACVR2B DNAH11 MYH7 NODAL ODAD2
12 respiratory system MP:0005388 9.61 ACVR2B CFAP53 DNAH11 DNAH5 DNAI1 NODAL
13 skeleton MP:0005390 9.32 ACVR2B DNAH11 DNAH5 DNAI1 HES7 NODAL

Drugs & Therapeutics for Dextrocardia

Drugs for Dextrocardia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
2 Hormone Antagonists Phase 4
3 Hormones Phase 4
4 diuretics Phase 4
5 Mineralocorticoid Receptor Antagonists Phase 4
6 Diuretics, Potassium Sparing Phase 4
7 Natriuretic Peptide, Brain Phase 4
8 Mineralocorticoids Phase 4
9
Ambrisentan Approved, Investigational Phase 2 177036-94-1 6918493
10
Simendan Investigational Phase 2 131741-08-7
11 Antihypertensive Agents Phase 2
12 Vasodilator Agents Phase 2
13 Protective Agents Phase 2
14 Cardiotonic Agents Phase 2
15 Phosphodiesterase Inhibitors Phase 2
16 Phosphodiesterase 3 Inhibitors Phase 2
17 Pharmaceutical Solutions Phase 2
18 Liver Extracts
19 Phosphodiesterase 5 Inhibitors
20 Respiratory System Agents

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Water Immersion in Right-Sided Heart Failure: A Pilot Study Completed NCT00654264 Phase 4
2 Spironolactone Therapy in Chronic Stable Right HF Trial Suspended NCT03344159 Phase 4 Spironolactone;Placebo
3 Safety, Pharmacokinetics (PK) and Hemodynamic Effects of Ambrisentan in Single Ventricle Pediatric Patients Completed NCT02080637 Phase 2 Ambrisentan
4 Open-Label Rollover Study of Levosimendan in Patients With Pulmonary Hypertension With Heart Failure and Preserved Left Ventricular Ejection Fraction (PH-HFpEF) Active, not recruiting NCT03624010 Phase 2 Levosimendan 2.5 mg/ml Injectable Solution
5 Severe and Transient Hypoxemia During Selective Intra-arterial Chemotherapy for Retinoblastoma in Children: Evaluation of the Right-sided Heart Function. Unknown status NCT03559894
6 Transcatheter Valve Implantation in Patients With Dysfunctional Left and Right Sided Heart Valves Completed NCT02119442
7 Evaluation of Multimodal Monitoring Technologies in the Peri-operative Care of Cardiac Surgical Patients Completed NCT02658006
8 Non-invasive Assessment of Liver Stiffness/Fibrosis by Transient Elastography (Fibroscan) in Patients With Left and/or Right Sided Heart Failure Completed NCT00777725
9 Assessment of Portal Flow Using Bedside Doppler Ultrasonography for the Detection of Portal Pulsatility as a Risk Factor for Acute Kidney Injury in Cardiac Surgery Patients Completed NCT02831907
10 Right Ventricular Function After Withdrawal of Phosphodiesterase-5 Inhibitors in Left Ventricular Assist Device Recipients Recruiting NCT04117659
11 Open Lung Strategy in Critically Ill Morbid Obese Patients Lung Imaging and Heart-lung Interaction Active, not recruiting NCT02503241
12 Cardiac Metabolic Remodeling After Pulmonary Vasodilator Therapy in Pulmonary Arterial Hypertension: A Pilot Study Terminated NCT04090866

Search NIH Clinical Center for Dextrocardia

Cochrane evidence based reviews: dextrocardia

Genetic Tests for Dextrocardia

Genetic tests related to Dextrocardia:

# Genetic test Affiliating Genes
1 Dextrocardia 29

Anatomical Context for Dextrocardia

MalaCards organs/tissues related to Dextrocardia:

40
Heart, Lung, Spleen, Liver, Brain, Bone Marrow, Eye

Publications for Dextrocardia

Articles related to Dextrocardia:

(show top 50) (show all 1455)
# Title Authors PMID Year
1
Pulmonary root translocation in corrected transposition of great arteries with ventricular septal defect and pulmonary stenosis with dextrocardia. 61
33331022 2021
2
Catheter ablation of atrial fibrillation in situs inversus dextrocardia: Challenge, improved procedure, outcomes, and literature review. 61
33372281 2021
3
Characteristics and outcomes of fetuses with laterality defects are the current outcomes better? A single center study. 61
31106637 2021
4
Prenatal characterization of a novel inverted SMAD2 duplication by mate pair sequencing in a fetus with dextrocardia. 61
33598243 2021
5
Unsupervised Deep Anomaly Detection in Chest Radiographs. 61
33555397 2021
6
Successful left bundle branch pacing in a patient with dextrocardia using a modified sheath. 61
33293497 2021
7
Upgrading from a Dual-chamber Pacemaker to a Cardiac Resynchronization Therapy Defibrillator in Situs Inversus Totalis with Dextrocardia Following Mitral Valve Replacement and Tricuspid Annuloplasty Using a Left-sided Approach. 61
33520351 2021
8
Dextrocardia and atrial fibrillation ablation: relevance of anatomy. 61
32651868 2021
9
Routine pre-employment echocardiography assessment in young adults: cost and benefits. 61
33409841 2021
10
Autologous vascularised pericardial flap tunneling technique in Scimitar syndrome repair with dextrocardia: lessons from the Senning procedure. 61
33446287 2021
11
Successful thoracoscopic treatment for tracheoesophageal fistula and esophageal atresia of communicating bronchopulmonary foregut malformation group IB with dextrocardia: a case report of VACTERL association. 61
33409676 2021
12
Successful Radiofrequency Ablation of Recurrent Supraventricular Tachycardia in a Patient with Complex Congenital Heart Disease. 61
33262322 2020
13
Guiding extension catheter facilitated percutaneous coronary intervention for a dextrocardia patient with acute left anterior descending artery occlusion: a case report. 61
33424948 2020
14
Left bundle branch area pacing after His bundle pacing for cardiac resynchronization in a patient with dextrocardia. 61
33365236 2020
15
Assessment of Myocardial Viability Using Nuclear Medicine Imaging in Dextrocardia. 61
32887761 2020
16
Trans-coronary sinus puncture for catheter ablation and left atrial appendage closure device implantation in a patient with dextrocardia and persistent right superior vena cava. 61
33365235 2020
17
Video-assisted minimally invasive aortic valve replacement through left anterior mini-thoracotomy in a patient with situs inversus totalis. 61
32584985 2020
18
A rare cardiac phenotype of dextrocardia observed in a fetus with 1p36 deletion syndrome and a balanced translocation: a prenatal case report. 61
33292381 2020
19
'Hybrid' Bronchopulmonary Malformation - Lobar Emphysema and Extra Lobar Sequestration. 61
33252288 2020
20
An ST-Elevation Myocardial Infarction In Situs Inversus Totalis (DEXTROCARDIA). 61
32713619 2020
21
Senning with Aortic Translocation, Anatomic Repair for Congenitally Corrected Transposition. 61
33045205 2020
22
Atrial fibrillation and atrial flutter ablation using mirror image in a patient with dextrocardia with situs inversus. 61
33001046 2020
23
Lung transplantation for Kartagener syndrome: technical aspects and morphological adaptation of the transplanted lungs. 61
33026567 2020
24
Deterioration of chest wall depression causing congestive hepatopathy after an open thoracostomy window in a patient with pectus excavatum and tuberculosis empyema. 61
31679134 2020
25
Congenital right ventricular diverticulum: An atypical presentation. 61
33311932 2020
26
Acute coronary syndrome in Dextrocardia: Case report. 61
32933811 2020
27
Radiofrequency catheter ablation in a patient with dextrocardia, persistent left superior vena cava, and atrioventricular nodal reentrant tachycardia: A case report. 61
32899085 2020
28
Percutaneous mitral valve repair in adults with congenital heart disease: Report of the first case-series. 61
32898313 2020
29
Off-Pump "Clamp and Sew" Extracardiac Fontan With Inverted Bifurcated Graft for Dextrocardia With Heterotaxy Syndrome. 61
32853072 2020
30
When the left atrium becomes a monster: a case report. 61
32974461 2020
31
Mirror-image dextrocardia: why is the apex impulse not on the right? 61
32761359 2020
32
Percutaneous coronary intervention in dextrocardia: a case report and a brief review of the literature. 61
32618762 2020
33
Feasibility of novel transapical off pump beating heart mitral valve repair in a patient with dextrocardia and situs inversus. 61
32155238 2020
34
Unconventional deployment of atrial septal occluder in a patient with atrial septal defect, dextrocardia, and interrupted inferior vena cava. 61
32594956 2020
35
Left bundle branch pacing in a patient with mirror image dextrocardia and persistent right superior vena cava. 61
32748941 2020
36
Percutaneous coronary intervention for left main coronary artery stenosis in a patient with dextrocardia. 61
31087254 2020
37
A case report of late-onset symptoms of erythrocytosis in univentricular dextrocardia. 61
32629741 2020
38
Tetralogy of Fallot With Dextrocardia and Anomalous Coronary Artery: A Case Report. 61
32195621 2020
39
Right Lung Agenesis Associated with Dextrocardia and Pulmonary Hypertension. 61
31300255 2020
40
Congenitally Corrected Transposition of Great Arteries with Dextrocardia, Patent Ductus Arteriosus, Atrial Septal Defects and Ventricular Septal Defects in a 15-Year-Old Marfanoid Habitus Patient: A Case Study. 61
32765983 2020
41
Dextrocardia, situs solitus, inlet ventricular septal defect (VSD), and iatrogenic tricuspid regurgitation (TR)-A surgical perspective. 61
32349171 2020
42
ST-Elevation Myocardial Infarction in a Patient Having Dextrocardia with Situs Inversus. 61
32359913 2020
43
Adverse impact of univentricular pacing for the patient with functional single ventricle: successful conversion to cardiac resynchronization therapy. 61
32405970 2020
44
A new case with Hermansky-Pudlak syndrome type 9, a rare cause of syndromic albinism with severe defect of platelets dense bodies. 61
32245340 2020
45
Successful Multi-vessel Percutaneous Coronary Intervention for Recent Myocardial Infarction in a Patient with Dextrocardia and Situs Inversus. 61
32506107 2020
46
Exome-Based Case-Control Analysis Highlights the Pathogenic Role of Ciliary Genes in Transposition of the Great Arteries. 61
32078439 2020
47
Scoliosis Curvature Follows Thoracic Organ Orientation. 61
29952884 2020
48
Recurrent Peumonia in an Infant With an Esophageal Lung. 61
32198873 2020
49
Stress cardiomyopathy in dextrocardia with situs inversus and anomalous coronary arteries. 61
32131905 2020
50
Heart transplantation for dextrocardia: preoperative planning using 3D printing. 61
31620774 2020

Variations for Dextrocardia

ClinVar genetic disease variations for Dextrocardia:

6
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 CFAP53 NM_145020.5(CFAP53):c.472A>G (p.Arg158Gly) SNV Likely pathogenic 217132 rs886037751 18:47787435-47787435 18:50261065-50261065
2 CFAP53 NM_145020.5(CFAP53):c.301_473+1del Deletion Likely pathogenic 488411 rs1555672928 18:47787433-47787606 18:50261063-50261236
3 MYRF NM_001127392.3(MYRF):c.1786C>T (p.Gln596Ter) SNV Likely pathogenic 977137 11:61544931-61544931 11:61777459-61777459
4 ROCK2 NM_004850.5(ROCK2):c.3724C>T (p.Gln1242Ter) SNV Uncertain significance 545556 rs1558277937 2:11332802-11332802 2:11192676-11192676
5 RAI2 NM_021785.5(RAI2):c.712G>A (p.Val238Ile) SNV Uncertain significance 545561 rs1208705303 X:17819419-17819419 X:17801299-17801299
6 SUPT16H NM_007192.4(SUPT16H):c.956-1G>A SNV Uncertain significance 545562 rs1566388186 14:21834689-21834689 14:21366530-21366530
7 ZFYVE16 NM_001284236.3(ZFYVE16):c.1798G>A (p.Asp600Asn) SNV Uncertain significance 545559 rs1561277007 5:79734302-79734302 5:80438483-80438483
8 ZFYVE16 NM_001284236.3(ZFYVE16):c.3755G>C (p.Gly1252Ala) SNV Uncertain significance 545560 rs1561310640 5:79752344-79752344 5:80456525-80456525

Expression for Dextrocardia

Search GEO for disease gene expression data for Dextrocardia.

Pathways for Dextrocardia

Pathways related to Dextrocardia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.74 ZIC3 NODAL HES7 ACVR2B
2 11.49 ZIC3 NODAL ACVR2B
3 10.77 ZFYVE16 NODAL ACVR2B

GO Terms for Dextrocardia

Cellular components related to Dextrocardia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoskeleton GO:0005856 9.91 ROCK2 ODAD3 ODAD2 DNAI1 DNAH5 DNAH11
2 cell projection GO:0042995 9.88 ODAD3 ODAD2 DNAI1 DNAH5 DNAH11 CFAP53
3 axoneme GO:0005930 9.46 ODAD3 ODAD2 DNAH5 DNAH11
4 dynein complex GO:0030286 9.43 DNAI1 DNAH5 DNAH11
5 cilium GO:0005929 9.43 ODAD3 ODAD2 DNAI1 DNAH5 DNAH11 CFAP53
6 outer dynein arm GO:0036157 9.32 DNAI1 DNAH5
7 9+2 motile cilium GO:0097729 8.8 DNAI1 DNAH5 DNAH11

Biological processes related to Dextrocardia according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 heart development GO:0007507 9.73 STRA6 ODAD2 NODAL DNAI1 DNAH5 DNAH11
2 lung development GO:0030324 9.71 ZIC3 STRA6 NODAL
3 anterior/posterior pattern specification GO:0009952 9.71 ZIC3 NODAL HES7 ACVR2B
4 BMP signaling pathway GO:0030509 9.7 ZFYVE16 NODAL ACVR2B
5 microtubule-based movement GO:0007018 9.67 DNAI1 DNAH5 DNAH11
6 flagellated sperm motility GO:0030317 9.65 DNAI1 DNAH5 DNAH11
7 digestive tract morphogenesis GO:0048546 9.55 STRA6 NODAL
8 epithelial cilium movement involved in determination of left/right asymmetry GO:0060287 9.51 DNAH11 CFAP53
9 epithelial cilium movement GO:0003351 9.5 DNAI1 DNAH5 DNAH11
10 regulation of cilium beat frequency GO:0003356 9.46 ODAD2 DNAH11
11 outer dynein arm assembly GO:0036158 9.46 ODAD3 ODAD2 DNAI1 DNAH5
12 positive regulation of activin receptor signaling pathway GO:0032927 9.43 NODAL ACVR2B
13 cilium movement GO:0003341 9.43 ODAD3 ODAD2 DNAI1 DNAH5 DNAH11 CFAP53
14 determination of left/right asymmetry in nervous system GO:0035545 9.37 ZIC3 DNAH11
15 determination of left/right symmetry GO:0007368 9.23 ZIC3 ODAD3 ODAD2 NODAL DNAI1 DNAH5

Molecular functions related to Dextrocardia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dynein light intermediate chain binding GO:0051959 9.16 DNAH5 DNAH11
2 ATP-dependent microtubule motor activity, minus-end-directed GO:0008569 8.96 DNAH5 DNAH11
3 motor activity GO:0003774 8.92 MYH7 DNAI1 DNAH5 DNAH11

Sources for Dextrocardia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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