MCID: DXT001
MIFTS: 50

Dextrocardia

Categories: Cardiovascular diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Dextrocardia

MalaCards integrated aliases for Dextrocardia:

Name: Dextrocardia 12 76 53 59 29 6 44 15
Heart Predominantly in Right Hemithorax 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9565
ICD10 33 Q24.0
MeSH 44 D003914
NCIt 50 C84669
SNOMED-CT 68 27637000
Orphanet 59 ORPHA1666
UMLS via Orphanet 74 C0011813 C0265863
ICD10 via Orphanet 34 Q24.0
MESH via Orphanet 45 D003914
UMLS 73 C0011813

Summaries for Dextrocardia

NIH Rare Diseases : 53 Dextrocardia is a condition in which the heart is located in the right side of the chest instead of the left. It is usually present from birth (congenital). There are several types of dextrocardia.  The simplest type occurs when the shape and structure of the heart is a mirror image of a normal heart.  Other types of dextrocardia may involve defects of the walls of the heart, nearby blood vessels, or other organs in the abdomen. Chest X-raxys and echocardiograms can be used to determine which type of dextrocardia is present. 

MalaCards based summary : Dextrocardia, also known as heart predominantly in right hemithorax, is related to dextrocardia with situs inversus and situs inversus. An important gene associated with Dextrocardia is NODAL (Nodal Growth Differentiation Factor), and among its related pathways/superpathways are Mesodermal Commitment Pathway and TGF-beta signaling pathway (KEGG). The drugs Spironolactone and Tadalafil have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and spleen, and related phenotypes are hydrocephalus and global developmental delay

Wikipedia : 76 Dextrocardia (from Latin dexter, meaning "right," and Greek kardia, meaning "heart") is a rare... more...

Related Diseases for Dextrocardia

Diseases related to Dextrocardia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 142)
# Related Disease Score Top Affiliating Genes
1 dextrocardia with situs inversus 33.5 CFAP53 HES7 NODAL
2 situs inversus 31.1 CFAP53 DNAI1 NODAL
3 heterotaxy 29.8 ACVR2B CFAP53 NODAL
4 visceral heterotaxy 29.2 ACVR2B CFAP53 DNAI1 NODAL
5 short stature wormian bones dextrocardia 12.3
6 dextrocardia with unusual facies and microphthalmia 12.3
7 heterotaxy, visceral, 1, x-linked 11.9
8 kartagener syndrome 11.7
9 stratton-parker syndrome 11.6
10 ciliary dyskinesia, primary, 1 11.6
11 levocardia 11.3
12 heterotaxy, visceral, 5, autosomal 11.3
13 pagod syndrome 11.3
14 van allen myhre syndrome 11.0
15 marden-walker syndrome 11.0
16 heterotaxy, visceral, 4, autosomal 11.0
17 intellectual disability - athetosis - microphthalmia 11.0
18 myocardial infarction 10.5
19 double discordia 10.4
20 transposition of the great arteries 10.4
21 acute myocardial infarction 10.3
22 poland syndrome 10.3
23 ventricular septal defect 10.3
24 atrial fibrillation 10.2
25 heart disease 10.2
26 atrial heart septal defect 10.2
27 double outlet right ventricle 10.2
28 congenitally corrected transposition of the great arteries 10.2
29 tetralogy of fallot 10.1
30 arteries, anomalies of 10.1
31 progressive familial heart block, type ia 10.1
32 lung agenesis 10.1
33 coronary artery anomaly 10.1
34 bronchiectasis 10.1
35 atrial standstill 1 10.1
36 transposition of the great arteries, dextro-looped 1 10.1
37 tricuspid atresia 10.0
38 sinusitis 10.0
39 aortic coarctation 10.0
40 sick sinus syndrome 10.0
41 lutembacher's syndrome 10.0
42 ischemia 10.0
43 right aortic arch 9.9 ACVR2B CFAP53
44 total anomalous pulmonary venous return 1 9.9
45 cleft palate, isolated 9.9
46 tracheoesophageal fistula with or without esophageal atresia 9.9
47 wolff-parkinson-white syndrome 9.9
48 progressive familial heart block, type ib 9.9
49 atrioventricular septal defect 9.9
50 pulmonary hypertension 9.9

Graphical network of the top 20 diseases related to Dextrocardia:



Diseases related to Dextrocardia

Symptoms & Phenotypes for Dextrocardia

Human phenotypes related to Dextrocardia:

59 32 (show all 27)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hydrocephalus 59 32 very rare (1%) Very rare (<4-1%) HP:0000238
2 global developmental delay 59 32 very rare (1%) Very rare (<4-1%) HP:0001263
3 webbed neck 59 32 very rare (1%) Very rare (<4-1%) HP:0000465
4 abnormality of the foot 59 32 very rare (1%) Very rare (<4-1%) HP:0001760
5 congenital hip dislocation 59 32 very rare (1%) Very rare (<4-1%) HP:0001374
6 intestinal malrotation 59 32 occasional (7.5%) Occasional (29-5%) HP:0002566
7 abnormality of the spleen 59 32 occasional (7.5%) Occasional (29-5%) HP:0001743
8 abnormality of the ribs 59 32 very rare (1%) Very rare (<4-1%) HP:0000772
9 preauricular skin tag 59 32 very rare (1%) Very rare (<4-1%) HP:0000384
10 abnormality of the pulmonary artery 59 32 occasional (7.5%) Occasional (29-5%) HP:0004414
11 abnormality of the ureter 59 32 occasional (7.5%) Occasional (29-5%) HP:0000069
12 situs inversus totalis 59 32 frequent (33%) Frequent (79-30%) HP:0001696
13 neuroblastoma 59 32 very rare (1%) Very rare (<4-1%) HP:0003006
14 abnormal lung lobation 59 32 occasional (7.5%) Occasional (29-5%) HP:0002101
15 meckel diverticulum 59 32 very rare (1%) Very rare (<4-1%) HP:0002245
16 abnormal renal morphology 59 32 occasional (7.5%) Occasional (29-5%) HP:0012210
17 abnormal reproductive system morphology 59 32 occasional (7.5%) Occasional (29-5%) HP:0012243
18 pancreatic hypoplasia 59 32 very rare (1%) Very rare (<4-1%) HP:0002594
19 t-wave inversion 59 32 hallmark (90%) Very frequent (99-80%) HP:0010872
20 congenital malformation of the great arteries 59 32 frequent (33%) Frequent (79-30%) HP:0011603
21 abnormality of abdominal situs 59 32 occasional (7.5%) Occasional (29-5%) HP:0011620
22 aplasia/hypoplasia of the ear 59 32 very rare (1%) Very rare (<4-1%) HP:0008771
23 dextrocardia 59 Obligate (100%)
24 abnormal ekg 59 Very frequent (99-80%)
25 abnormal heart morphology 59 Very frequent (99-80%)
26 abnormality of pulmonary situs 59 Occasional (29-5%)
27 abnormal pulmonary situs morphology 32 occasional (7.5%) HP:0011615

MGI Mouse Phenotypes related to Dextrocardia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.86 ACVR2B CFAP53 CTC1 DNAI1 HES7 NODAL
2 cardiovascular system MP:0005385 9.85 ACVR2B CFAP53 DNAI1 NODAL STRA6 TNNT2
3 embryo MP:0005380 9.8 ACVR2B CFAP53 HES7 NODAL STRA6 TNNT2
4 immune system MP:0005387 9.63 ACVR2B CFAP53 CTC1 DNAI1 NODAL STRA6
5 mortality/aging MP:0010768 9.5 ACVR2B CTC1 DNAI1 HES7 NODAL STRA6
6 skeleton MP:0005390 9.02 ACVR2B DNAI1 HES7 NODAL STRA6

Drugs & Therapeutics for Dextrocardia

Drugs for Dextrocardia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 56)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Spironolactone Approved Phase 4 52-01-7, 1952-01-7 5833
2
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
3 Kava Approved, Investigational, Nutraceutical Phase 4 9000-38-8
4
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
5 Mineralocorticoids Phase 4
6 Hormones Phase 4
7 Natriuretic Agents Phase 4,Phase 3
8 Hormone Antagonists Phase 4
9 Sodium Channel Blockers Phase 4
10 diuretics Phase 4
11 Diuretics, Potassium Sparing Phase 4
12 Mineralocorticoid Receptor Antagonists Phase 4
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
14 Vasodilator Agents Phase 4,Phase 3,Phase 2,Not Applicable
15 Natriuretic Peptide, Brain Phase 4,Phase 3
16 Endothelin Receptor Antagonists Phase 4
17 Sildenafil Citrate Phase 4 171599-83-0
18 Phosphodiesterase Inhibitors Phase 4,Phase 2
19 Phosphodiesterase 5 Inhibitors Phase 4
20 Citrate Phase 4
21
Nitroglycerin Approved, Investigational Phase 3 55-63-0 4510
22
Ivacaftor Approved Phase 2 873054-44-5 16220172
23
Ambrisentan Approved, Investigational Phase 2 177036-94-1 6918493
24
Simvastatin Approved Phase 2 79902-63-9 54454
25
Aspirin Approved, Vet_approved Phase 2 50-78-2 2244
26 Simendan Investigational Phase 2 131741-08-7
27 Protective Agents Phase 2,Not Applicable
28 Peripheral Nervous System Agents Phase 2,Not Applicable
29 Pharmaceutical Solutions Phase 2
30 Cardiotonic Agents Phase 2
31 Anti-Arrhythmia Agents Phase 2
32 Antihypertensive Agents Phase 2
33 Anti-Inflammatory Agents, Non-Steroidal Phase 2
34 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 2
35 Analgesics, Non-Narcotic Phase 2
36 Anti-Inflammatory Agents Phase 2
37 Anticholesteremic Agents Phase 2
38 Cyclooxygenase Inhibitors Phase 2
39 Fibrinolytic Agents Phase 2
40 Antipyretics Phase 2
41 Hypolipidemic Agents Phase 2
42 Lipid Regulating Agents Phase 2
43 Antirheumatic Agents Phase 2
44 Platelet Aggregation Inhibitors Phase 2
45 Analgesics Phase 2
46 Antimetabolites Phase 2
47
Nitric Oxide Approved ,Not Applicable 10102-43-9 145068
48 Endothelium-Dependent Relaxing Factors ,Not Applicable
49 Free Radical Scavengers ,Not Applicable
50 Antioxidants ,Not Applicable

Interventional clinical trials:

(show top 50) (show all 57)
# Name Status NCT ID Phase Drugs
1 Effects of Spironolactone on Collagen Metabolism in Patients With Pulmonary Arterial Hypertension Unknown status NCT01468571 Phase 4 Spironolactone;Placebo
2 Water Immersion in Right-Sided Heart Failure: A Pilot Study Completed NCT00654264 Phase 4
3 Spironolactone Therapy in Chronic Stable Right HF Trial Recruiting NCT03344159 Phase 4 Spironolactone;Placebo
4 Heterotopic Implantation Of the Edwards-Sapien Transcatheter Aortic Valve in the Inferior VEna Cava for the Treatment of Severe Tricuspid Regurgitation (HOVER) Recruiting NCT02339974 Phase 4
5 Riociguat rEplacing PDE-5i Therapy evaLuated Against Continued PDE-5i thErapy Recruiting NCT02891850 Phase 4 Adempas (Riociguat, BAY63-2521);Sildenafil;Tadalafil
6 A Study Comparing Blood Flow and Clinical and Safety Effects of the Addition of Natrecor (Nesiritide), Placebo or Intravenous Nitroglycerin to Standard Care for the Treatment of Worsening Congestive Heart Failure. Completed NCT00270374 Phase 3 nesiritide
7 Ketones in Heart Failure - Effects on Cardiac Efficiency Completed NCT03073356 Phase 2
8 Acute Effects of Inorganic Nitrite on Cardiovascular Hemodynamics in Heart Failure With Preserved Ejection Fraction Completed NCT01932606 Phase 2 Nitrite;Saline Placebo for Nitrite
9 Clearing Lungs With ENaC Inhibition in Primary Ciliary Dyskinesia Completed NCT02871778 Phase 2 VX-371;Hypertonic Saline;Placebo (0.17% saline);Ivacaftor
10 Open-Label Rollover Study of Levosimendan in PH-HFpEF Patients Recruiting NCT03624010 Phase 2 Levosimendan 2.5 mg/ml Injectable Solution
11 Long-term Ambrisentan Extension Study for Pediatric Patients Who Participated in AMB112529 Recruiting NCT01342952 Phase 2 Ambrisentan
12 Ambrisentan in Single Ventricle Active, not recruiting NCT02080637 Phase 2 Ambrisentan
13 Efficacy and Safety of Ambrisentan in Children 8-18yrs Suspended NCT01332331 Phase 2 Ambrisentan - low dose;Ambrisentan - high dose
14 A Study of Aspirin and Simvastatin in Pulmonary Arterial Hypertension Terminated NCT00384865 Phase 2 Simvastatin;Aspirin;Placebo
15 Behaviour of Tricuspid Valve Regurgitation in Volume and/or Pressure Loaded Right Heart Unknown status NCT01444222
16 Early Detection and Characterization of Primary Ciliary Dyskinesia Unknown status NCT01070914
17 Screening for Primary Ciliary Dyskinesia Using Nasal Nitric Oxide Unknown status NCT00739817
18 Comparison of On-line and Off-line Measurements of Exhaled Nitric Oxide (NO) Unknown status NCT00686309
19 Transcatheter Valve Implantation in Patients With Dysfunctional Left and Right Sided Heart Valves Completed NCT02119442 Not Applicable
20 Non-invasive Assessment of Liver Stiffness/Fibrosis by Transient Elastography (Fibroscan) in Patients With Left and/or Right Sided Heart Failure Completed NCT00777725
21 Evaluation of Monitoring TECHNOlogies in the PERI-OPerative Care of Cardiac Surgical Patients Completed NCT02658006
22 Portal Flow Pulsatility as a Risk Factor for Acute Kidney Injury After Cardiac Surgery Completed NCT02831907
23 Pilot Chart Review Study Of Sitaxentan Sodium (Thelin) In Patients With Pulmonary Arterial Hypertension (PAH) Completed NCT01445873 Sitaxentan sodium
24 NIOX VERO Nasal Application in Primary Ciliary Dyskinesia Completed NCT02622061
25 Otolith Function in Patients With Primary Ciliary Dyskinesia Completed NCT01246258
26 Inflammatory and Microbiologic Markers in Sputum: Comparing Cystic Fibrosis With Primary Ciliary Dyskinesia Completed NCT01155115 Not Applicable
27 Diagnosis of Primary Ciliary Dyskinesia Completed NCT00783887
28 Dyskinesia, Heterotaxy and Congenital Heart Disease Completed NCT00608556
29 Genetic Study of Patients With Primary Ciliary Dyskinesia Completed NCT00005650
30 Pulmonary Endarterectomy Guided by CT Scanning for Patients With Chronic Thromboembolic Pulmonary Hypertension----PEACT Recruiting NCT03795740 Not Applicable
31 Imaging Control Study, 3D Echo, MR and RHC. Recruiting NCT02198456
32 Serial Multiparametric Evaluation of Right Ventricular Function After Left Ventricular Assist Device Implantation Recruiting NCT03552679
33 Molecular Genetics of Heterotaxy and Related Congenital Heart Defects Recruiting NCT02432079
34 Global Congestive Heart Failure Registry Recruiting NCT03078166
35 WGS of Korean Idiopathic Bronchiectasis Recruiting NCT03809091
36 PCD New Gene Discovery Recruiting NCT03801395
37 Utility of PCD Diagnostics to Improve Clinical Care Recruiting NCT03704207 Not Applicable
38 Swiss Primary Ciliary Dyskinesia Registry Recruiting NCT03606200
39 International Primary Ciliary Dyskinesia Cohort Recruiting NCT03517865
40 Bacteriological Link Between Upper and Lower Airways in Cystic Fibrosis and Primary Ciliary Dyskinesia Recruiting NCT03494894
41 Respiratory Muscle Strength, Exercise Capacity and Physical Activity Levels in Children Primary Ciliary Dyskinesia Recruiting NCT03370029
42 Multiple Breath Washout, a Clinimetric Dataset Recruiting NCT03320382
43 MRI in Cystic Fibrosis and Primary Ciliary Dyskinesia Recruiting NCT03279965
44 Registry for Primary Ciliary Dyskinesia Recruiting NCT03271840
45 High Resolution Micro OCT Imaging Recruiting NCT03256773
46 International Prospective Patient Registry for Primary Ciliary Dyskinesia (PCD) Recruiting NCT02419365
47 Pathogenesis of Primary Ciliary Dyskinesia (PCD) Lung Disease Recruiting NCT00807482
48 Severe and Transient Hypoxemia During Selective Intra-arterial Chemotherapy for Retinoblastoma in Children: Evaluation of the Right-sided Heart Function. Active, not recruiting NCT03559894
49 Open Lung Strategy in Critically Ill Morbid Obese Patients Active, not recruiting NCT02503241 Not Applicable
50 PRospective Observational Multicentre Study on VAriability of Lung Function in Stable PCD Patients Active, not recruiting NCT03704896

Search NIH Clinical Center for Dextrocardia

Cochrane evidence based reviews: dextrocardia

Genetic Tests for Dextrocardia

Genetic tests related to Dextrocardia:

# Genetic test Affiliating Genes
1 Dextrocardia 29

Anatomical Context for Dextrocardia

MalaCards organs/tissues related to Dextrocardia:

41
Heart, Lung, Spleen, Liver, Skin, Kidney, Bone

Publications for Dextrocardia

Articles related to Dextrocardia:

(show top 50) (show all 632)
# Title Authors Year
1
Mitral valve replacement via a left thoracotomy in dextrocardia and situs solitus. ( 29338299 )
2018
2
Acute Myocardial Infarction in a Patient with Isolated Dextrocardia. ( 29431312 )
2018
3
Response by Liu and Li to Letter Regarding Article, &amp;quot;Dextrocardia: Why Significant Left Axis Deviation?&amp;quot; ( 29735599 )
2018
4
Quantitation in Dextrocardia on myocardial perfusion imaging: how to perform quantitative analysis using Cedars-Sinai software. ( 29442348 )
2018
5
Late diagnosis of a congenitally corrected transposition of the great arteries discovered at pacemaker implantation in a patient previously diagnosed with dextrocardia and situs solitus. ( 29881577 )
2018
6
Successful Catheter Treatment Using Pre-Operative 3D Organ Model Simulation for Atrial Septal Defect With Dextrocardia and Interrupted Inferior Vena Cava toA theA Superior Vena Cava. ( 29605245 )
2018
7
Hepatoblastoma in a child with dextrocardia and possible histopathological alteration reminiscent of hepatocellular carcinoma after neoadjuvant chemotherapy. ( 29881566 )
2018
8
Transcatheter Aortic Valve Replacement in a Patient with Dextrocardia and Situs Inversus Totalis. ( 29908190 )
2018
9
Electrocardiographic Findings in a Woman With Dextrocardia and Cyanosis. ( 29946689 )
2018
10
Management of scar-related atrial flutter in a patient with dextrocardia, inferior vena cava interruption, and azygos continuation. ( 29424736 )
2018
11
A case of dextrocardia following maternal exposure to generic Fingolimod during the first trimester of pregnancy. ( 29474980 )
2018
12
Letter by Yi-tong Regarding Article, &amp;quot;Dextrocardia: Why Significant Left-Axis Deviation?&amp;quot; ( 29735598 )
2018
13
Successful catheter ablation of a focal atrial tachycardia originating from the coronary sinus ostium in a patient with a history of Fontan conversion and dextrocardia. ( 29688296 )
2018
14
Revisiting Atrioventricular Nodal Ablation and Cardiac Pacing of Atrial Fibrillation in a Patient with Dextrocardia. ( 29666358 )
2018
15
Acute myocardial infarction in dextrocardia - A diagnostic and therapeutic challenge. Can dextrocardia be a risk factor? ( 30279853 )
2018
16
Trans-aortic pulmonary vein isolation using magnetic navigation system for paroxysmal atrial fibrillation in a patient with dextrocardia, situs inversus, and inferior vena cava continuity with azygos vein. ( 30327707 )
2018
17
Transcatheter aortic valve implantation for severe aortic stenosis in dextrocardia with situs inversus using a self-expanding aortic valve. ( 30279894 )
2018
18
Transcatheter atrioventricular valve-in-valve implantation for Fontan circulation and dextrocardia. ( 30312393 )
2018
19
Comparison of Morphologic Findings in Patients with Dextrocardia with Situs Solitus vs Situs Inversus: a Retrospective Study. ( 30334087 )
2018
20
Implantation of a completely right sided subcutaneous cardioverter-defibrillator in a patient with situs inversus dextrocardia. ( 30468861 )
2018
21
Persistent dextrocardia after adult orthotopic heart transplantation in a patient with complex congenital heart disease. ( 30528511 )
2018
22
Just flip it!-CRT implantation in a patient with dextrocardia and situs inversus totalis. ( 30555613 )
2018
23
Cryoballoon ablation under transesophageal echocardiographic guidance in dextrocardia. ( 29704566 )
2018
24
Augmented-reality computed tomography-guided transcatheter pacemaker implantation in dextrocardia and congenitally corrected transposition of great arteries. ( 29961937 )
2018
25
Successful Heart Transplantation in Two Infants with Dextrocardia-Heterotaxy Syndrome. ( 30081023 )
2018
26
Senning Procedure for Transposition of the Great Arteries in a Patient with Situs Inversus Totalis and Dextrocardia. ( 30173681 )
2018
27
d-transposition of great arteries, dextrocardia with aberrant origin of right subclavian artery from pulmonary artery. ( 30206995 )
2018
28
Subcutaneous implantable defibrillator in dextrocardia secondary to Lobectomy. ( 30214751 )
2018
29
Partition of common atrioventricular valve in a patient with dextrocardia and univentricular circulation. ( 30273646 )
2018
30
Comparing levocardia and dextrocardia in fetuses with heterotaxy syndrome: prenatal features, clinical significance and outcomes. ( 29169330 )
2017
31
Successful percutaneous coronary intervention for an in-stent chronic total occlusion in a patient with dextrocardia: a case report. ( 29145812 )
2017
32
Assessment of coronary artery disease based on coronary flow velocity reserve by transthoracic Doppler echocardiography and coronary computed tomography angiography in a patient with dextrocardia: a case report. ( 29247297 )
2017
33
Review of surgical and anesthetic management for esophageal atresia with tracheoesophageal fistula, unilateral pulmonary agenesis and dextrocardia. ( 28417152 )
2017
34
Unexpected mirror-image dextrocardia in a patient with ST elevation myocardial infarction. ( 28891179 )
2017
35
An unusual cause of 'dextrocardia'. ( 28087601 )
2017
36
Catheter ablation of premature ventricular contractions originating from aortic sinus cusps in a patient with dextrocardia and situs solitus: A case report. ( 29310391 )
2017
37
Surgical challenge in situs inversus with dextrocardia and Lutembacher syndrome. ( 29214824 )
2017
38
Case 4/2017 - Double-Chambered Right Ventricle with Dextrocardia and Hypoxemia Due to Atrial Shunt in a 4-Year-Old Girl. ( 28699979 )
2017
39
Successful Drug-eluting Stent Implantation in a Male Patient with Dextrocardia: A Case Report. ( 29340305 )
2017
40
Prenatal Diagnosis of Dextrocardia with Complex Congenital Heart Disease Using Fetal Intelligent Navigation Echocardiography (FINE) and a Literature Review. ( 28641300 )
2017
41
Aeroembolism in left atrium during catheter ablation of atrial fibrillation in a patient with dextrocardia: a case report and review of the literature. ( 28577360 )
2017
42
Goldenhar Syndrome with Dextrocardia and Right Pulmonary Hypoplasia: An Unusual Association. ( 28377826 )
2017
43
Left side approach for aortic valve replacement in patient with dextrocardia and situs inversus totalis. ( 28983174 )
2017
44
Radiofrequency Pulmonary Vein Isolation in a Patient with Dextrocardia With Situs Inversus Totalis. ( 28462889 )
2017
45
An unusual combination of mirror-image dextrocardia with familial medulloblastoma : Is there a histogenetic relationship? ( 28844926 )
2017
46
Dextrocardia: Why Significant Left-Axis Deviation? ( 29061578 )
2017
47
Dextrocardia With Situs Inversus and Levo-Transposition of Great Vessels. ( 28641729 )
2017
48
Successful left transradial coronary angiography in an elderly patient with dextrocardia and severe aortic stenosis. ( 28529182 )
2017
49
Dextrocardia with asymptomatic right atrial appendage aneurysm: a case report. ( 29152268 )
2017
50
Image Diagnosis: Multivessel Percutaneous Coronary Intervention in Dextrocardia: Success with Usual Techniques in a Case of Mirror-Image Heart. ( 28633731 )
2017

Variations for Dextrocardia

ClinVar genetic disease variations for Dextrocardia:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 CFAP53 NM_145020.4(CFAP53): c.472A> G (p.Arg158Gly) single nucleotide variant Likely pathogenic rs886037751 GRCh38 Chromosome 18, 50261065: 50261065
2 CFAP53 NM_145020.4(CFAP53): c.472A> G (p.Arg158Gly) single nucleotide variant Likely pathogenic rs886037751 GRCh37 Chromosome 18, 47787435: 47787435
3 CFAP53 NM_145020.4(CFAP53): c.300_473del174 (p.Leu101_Arg158del) deletion Likely pathogenic GRCh38 Chromosome 18, 50261064: 50261237
4 CFAP53 NM_145020.4(CFAP53): c.300_473del174 (p.Leu101_Arg158del) deletion Likely pathogenic GRCh37 Chromosome 18, 47787434: 47787607

Expression for Dextrocardia

Search GEO for disease gene expression data for Dextrocardia.

Pathways for Dextrocardia

Pathways related to Dextrocardia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.28 ACVR2B HES7 NODAL
2 11.18 ACVR2B NODAL
3 10.88 NODAL TNNT2
4
Show member pathways
10.65 ACVR2B NODAL

GO Terms for Dextrocardia

Biological processes related to Dextrocardia according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 anterior/posterior pattern specification GO:0009952 9.49 ACVR2B NODAL
2 BMP signaling pathway GO:0030509 9.48 ACVR2B NODAL
3 regulation of signal transduction GO:0009966 9.46 ACVR2B NODAL
4 mesoderm development GO:0007498 9.43 ACVR2B HES7
5 lung development GO:0030324 9.43 ACVR2B NODAL STRA6
6 cilium movement GO:0003341 9.4 CFAP53 DNAI1
7 gastrulation with mouth forming second GO:0001702 9.37 ACVR2B NODAL
8 digestive tract morphogenesis GO:0048546 9.32 NODAL STRA6
9 heart development GO:0007507 9.26 ACVR2B DNAI1 NODAL STRA6
10 positive regulation of activin receptor signaling pathway GO:0032927 9.16 ACVR2B NODAL
11 determination of left/right symmetry GO:0007368 8.92 ACVR2B CFAP53 DNAI1 NODAL

Sources for Dextrocardia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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