MCID: DXT001
MIFTS: 52

Dextrocardia

Categories: Rare diseases, Cardiovascular diseases, Fetal diseases

Aliases & Classifications for Dextrocardia

MalaCards integrated aliases for Dextrocardia:

Name: Dextrocardia 12 76 53 59 29 6 44 15
Heart Predominantly in Right Hemithorax 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9565
ICD10 33 Q24.0
MeSH 44 D003914
NCIt 50 C84669
SNOMED-CT 68 156925007 27637000
Orphanet 59 ORPHA1666
UMLS via Orphanet 74 C0011813 C0265863
ICD10 via Orphanet 34 Q24.0
MESH via Orphanet 45 D003914
UMLS 73 C0011813

Summaries for Dextrocardia

NIH Rare Diseases : 53 Dextrocardia is a condition in which the heart is located in the right side of the chest instead of the left. It is usually present from birth (congenital). There are several types of dextrocardia.  The simplest type occurs when the shape and structure of the heart is a mirror image of a normal heart.  Other types of dextrocardia may involve defects of the walls of the heart, nearby blood vessels, or other organs in the abdomen. Chest X-raxys and echocardiograms can be used to determine which type of dextrocardia is present. 

MalaCards based summary : Dextrocardia, also known as heart predominantly in right hemithorax, is related to dextrocardia with situs inversus and situs inversus. An important gene associated with Dextrocardia is NODAL (Nodal Growth Differentiation Factor), and among its related pathways/superpathways are Mesodermal Commitment Pathway and TGF-beta signaling pathway (KEGG). The drugs Spironolactone and Tadalafil have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and liver, and related phenotypes are t-wave inversion and situs inversus totalis

Wikipedia : 76 Dextrocardia (from Latin dexter, meaning \"right,\" and Greek kardia, meaning \"heart\") is a rare... more...

Related Diseases for Dextrocardia

Diseases related to Dextrocardia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 146)
# Related Disease Score Top Affiliating Genes
1 dextrocardia with situs inversus 32.8 CFAP53 HES7 NODAL
2 situs inversus 30.2 CFAP53 DNAI1 NODAL
3 ventricular septal defect 29.5 MYH7 NODAL
4 heterotaxy 28.9 ACVR2B CFAP53 NODAL
5 dextrocardia with unusual facies and microphthalmia 12.1
6 short stature wormian bones dextrocardia 12.1
7 heterotaxy, visceral, 1, x-linked 11.7
8 kartagener syndrome 11.5
9 ciliary dyskinesia, primary, 1 11.5
10 levocardia 11.2
11 heterotaxy, visceral, 5, autosomal 11.2
12 pagod syndrome 11.1
13 stratton-parker syndrome 10.9
14 marden-walker syndrome 10.9
15 heterotaxy, visceral, 4, autosomal 10.9
16 van allen myhre syndrome 10.9
17 myocardial infarction 10.3
18 double discordia 10.2
19 transposition of the great arteries 10.2
20 acute myocardial infarction 10.1
21 poland syndrome 10.1
22 atrial heart septal defect 10.1
23 atrial fibrillation 10.1
24 heart disease 10.0
25 congenitally corrected transposition of the great arteries 10.0
26 double outlet right ventricle 10.0
27 arteries, anomalies of 9.9
28 progressive familial heart block, type ia 9.9
29 tetralogy of fallot 9.9
30 lung agenesis 9.9
31 coronary artery anomaly 9.9
32 bronchiectasis 9.9
33 transposition of the great arteries, dextro-looped 1 9.9
34 aneurysm 9.9
35 atrial standstill 1 9.9
36 tricuspid atresia 9.9
37 sinusitis 9.9
38 aortic coarctation 9.9
39 sick sinus syndrome 9.8
40 right aortic arch 9.7 ACVR2B CFAP53
41 total anomalous pulmonary venous return 1 9.7
42 cleft palate, isolated 9.7
43 tracheoesophageal fistula with or without esophageal atresia 9.7
44 wolff-parkinson-white syndrome 9.7
45 progressive familial heart block, type ib 9.7
46 atrioventricular septal defect 9.7
47 pulmonary hypertension 9.7
48 rheumatic heart disease 9.7
49 left bundle branch hemiblock 9.7
50 diaphragmatic eventration 9.7

Graphical network of the top 20 diseases related to Dextrocardia:



Diseases related to Dextrocardia

Symptoms & Phenotypes for Dextrocardia

Human phenotypes related to Dextrocardia:

59 32 (show all 28)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 t-wave inversion 59 32 hallmark (90%) Very frequent (99-80%) HP:0010872
2 situs inversus totalis 59 32 frequent (33%) Frequent (79-30%) HP:0001696
3 congenital malformation of the great arteries 59 32 frequent (33%) Frequent (79-30%) HP:0011603
4 abnormality of the ureter 59 32 occasional (7.5%) Occasional (29-5%) HP:0000069
5 abnormality of the spleen 59 32 occasional (7.5%) Occasional (29-5%) HP:0001743
6 abnormal lung lobation 59 32 occasional (7.5%) Occasional (29-5%) HP:0002101
7 intestinal malrotation 59 32 occasional (7.5%) Occasional (29-5%) HP:0002566
8 abnormality of the pulmonary artery 59 32 occasional (7.5%) Occasional (29-5%) HP:0004414
9 abnormality of abdominal situs 59 32 occasional (7.5%) Occasional (29-5%) HP:0011620
10 abnormal renal morphology 59 32 occasional (7.5%) Occasional (29-5%) HP:0012210
11 hydrocephalus 59 32 very rare (1%) Very rare (<4-1%) HP:0000238
12 preauricular skin tag 59 32 very rare (1%) Very rare (<4-1%) HP:0000384
13 webbed neck 59 32 very rare (1%) Very rare (<4-1%) HP:0000465
14 abnormality of the ribs 59 32 very rare (1%) Very rare (<4-1%) HP:0000772
15 global developmental delay 59 32 very rare (1%) Very rare (<4-1%) HP:0001263
16 congenital hip dislocation 59 32 very rare (1%) Very rare (<4-1%) HP:0001374
17 abnormality of the foot 59 32 very rare (1%) Very rare (<4-1%) HP:0001760
18 meckel diverticulum 59 32 very rare (1%) Very rare (<4-1%) HP:0002245
19 pancreatic hypoplasia 59 32 very rare (1%) Very rare (<4-1%) HP:0002594
20 neuroblastoma 59 32 very rare (1%) Very rare (<4-1%) HP:0003006
21 aplasia/hypoplasia of the ear 59 32 very rare (1%) Very rare (<4-1%) HP:0008771
22 dextrocardia 59 Obligate (100%)
23 abnormal heart morphology 59 Very frequent (99-80%)
24 abnormal ekg 59 Very frequent (99-80%)
25 abnormality of pulmonary situs 59 Occasional (29-5%)
26 abnormal genital system morphology 59 Occasional (29-5%)
27 abnormal pulmonary situs morphology 32 occasional (7.5%) HP:0011615
28 abnormal reproductive system morphology 32 occasional (7.5%) HP:0012243

Drugs & Therapeutics for Dextrocardia

Drugs for Dextrocardia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 51)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
2
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
3 Kava Approved, Investigational, Nutraceutical Phase 4 9000-38-8
4
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
5 diuretics Phase 4
6 Mineralocorticoid Receptor Antagonists Phase 4
7 Mineralocorticoids Phase 4
8 Natriuretic Agents Phase 4,Phase 3
9 Sodium Channel Blockers Phase 4
10 Hormone Antagonists Phase 4
11 Hormones Phase 4
12 Diuretics, Potassium Sparing Phase 4
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
14 Vasodilator Agents Phase 4,Phase 3,Not Applicable
15 Natriuretic Peptide, Brain Phase 4,Phase 3
16 Endothelin Receptor Antagonists Phase 4
17 Sildenafil Citrate Phase 4 171599-83-0
18 Phosphodiesterase 5 Inhibitors Phase 4
19 Phosphodiesterase Inhibitors Phase 4
20 Citrate Nutraceutical Phase 4
21
Nitroglycerin Approved, Investigational Phase 3 55-63-0 4510
22
Simvastatin Approved Phase 2 79902-63-9 54454
23
Aspirin Approved, Vet_approved Phase 2 50-78-2 2244
24 Peripheral Nervous System Agents Phase 2,Not Applicable
25 Antihypertensive Agents Phase 2
26 Pharmaceutical Solutions Phase 2
27 Analgesics Phase 2
28 Fibrinolytic Agents Phase 2
29 Cyclooxygenase Inhibitors Phase 2
30 Analgesics, Non-Narcotic Phase 2
31 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 2
32 Hypolipidemic Agents Phase 2
33 Anticholesteremic Agents Phase 2
34 Platelet Aggregation Inhibitors Phase 2
35 Lipid Regulating Agents Phase 2
36 Anti-Inflammatory Agents Phase 2
37 Antipyretics Phase 2
38 Anti-Inflammatory Agents, Non-Steroidal Phase 2
39 Antirheumatic Agents Phase 2
40 Antimetabolites Phase 2
41
Nitric Oxide Approved ,Not Applicable 10102-43-9 145068 160954
42
Menthol Approved Not Applicable 2216-51-5 16666
43 Respiratory System Agents ,Not Applicable
44 Neurotransmitter Agents ,Not Applicable
45 Anti-Asthmatic Agents ,Not Applicable
46 Endothelium-Dependent Relaxing Factors ,Not Applicable
47 Antioxidants ,Not Applicable
48 Protective Agents ,Not Applicable
49 Autonomic Agents ,Not Applicable
50 Bronchodilator Agents ,Not Applicable

Interventional clinical trials:

(show all 50)
# Name Status NCT ID Phase Drugs
1 Effects of Spironolactone on Collagen Metabolism in Patients With Pulmonary Arterial Hypertension Unknown status NCT01468571 Phase 4 Spironolactone;Placebo
2 Water Immersion in Right-Sided Heart Failure: A Pilot Study Completed NCT00654264 Phase 4
3 Spironolactone Therapy in Chronic Stable Right HF Trial Recruiting NCT03344159 Phase 4 Spironolactone;Placebo
4 Riociguat rEplacing PDE-5i Therapy evaLuated Against Continued PDE-5i thErapy Recruiting NCT02891850 Phase 4 Adempas (Riociguat, BAY63-2521);Sildenafil;Tadalafil
5 Heterotopic Implantation Of the Edwards-Sapien Transcatheter Aortic Valve in the Inferior VEna Cava for the Treatment of Severe Tricuspid Regurgitation (HOVER) Recruiting NCT02339974 Phase 4
6 A Study Comparing Blood Flow and Clinical and Safety Effects of the Addition of Natrecor (Nesiritide), Placebo or Intravenous Nitroglycerin to Standard Care for the Treatment of Worsening Congestive Heart Failure. Completed NCT00270374 Phase 3 nesiritide
7 Ketones in Heart Failure - Effects on Cardiac Efficiency Completed NCT03073356 Phase 2
8 Acute Effects of Inorganic Nitrite on Cardiovascular Hemodynamics in Heart Failure With Preserved Ejection Fraction Completed NCT01932606 Phase 2 Nitrite;Saline Placebo for Nitrite
9 Long-term Ambrisentan Extension Study for Pediatric Patients Who Participated in AMB112529 Recruiting NCT01342952 Phase 2 Ambrisentan
10 Ambrisentan in Single Ventricle Active, not recruiting NCT02080637 Phase 2 Ambrisentan
11 Clearing Lungs With ENaC Inhibition in Primary Ciliary Dyskinesia Active, not recruiting NCT02871778 Phase 2 VX-371;Hypertonic Saline;Placebo (0.17% saline);Ivacaftor
12 Efficacy and Safety of Ambrisentan in Children 8-18yrs Suspended NCT01332331 Phase 2 Ambrisentan - low dose;Ambrisentan - high dose
13 A Study of Aspirin and Simvastatin in Pulmonary Arterial Hypertension Terminated NCT00384865 Phase 2 Simvastatin;Aspirin;Placebo
14 Behaviour of Tricuspid Valve Regurgitation in Volume and/or Pressure Loaded Right Heart Unknown status NCT01444222
15 Early Detection and Characterization of Primary Ciliary Dyskinesia Unknown status NCT01070914
16 Screening for Primary Ciliary Dyskinesia Using Nasal Nitric Oxide Unknown status NCT00739817
17 Comparison of On-line and Off-line Measurements of Exhaled Nitric Oxide (NO) Unknown status NCT00686309
18 Transcatheter Valve Implantation in Patients With Dysfunctional Left and Right Sided Heart Valves Completed NCT02119442 Not Applicable
19 Non-invasive Assessment of Liver Stiffness/Fibrosis by Transient Elastography (Fibroscan) in Patients With Left and/or Right Sided Heart Failure Completed NCT00777725
20 Evaluation of Monitoring TECHNOlogies in the PERI-OPerative Care of Cardiac Surgical Patients Completed NCT02658006
21 Portal Flow Pulsatility as a Risk Factor for Acute Kidney Injury After Cardiac Surgery Completed NCT02831907
22 Pilot Chart Review Study Of Sitaxentan Sodium (Thelin) In Patients With Pulmonary Arterial Hypertension (PAH) Completed NCT01445873 Sitaxentan sodium
23 NIOX VERO Nasal Application in Primary Ciliary Dyskinesia Completed NCT02622061
24 Otolith Function in Patients With Primary Ciliary Dyskinesia Completed NCT01246258
25 Inflammatory and Microbiologic Markers in Sputum: Comparing Cystic Fibrosis With Primary Ciliary Dyskinesia Completed NCT01155115 Not Applicable
26 Diagnosis of Primary Ciliary Dyskinesia Completed NCT00783887
27 Dyskinesia, Heterotaxy and Congenital Heart Disease Completed NCT00608556
28 Genetic Study of Patients With Primary Ciliary Dyskinesia Completed NCT00005650
29 Imaging Control Study, 3D Echo, MR and RHC. Recruiting NCT02198456
30 Serial Multiparametric Evaluation of Right Ventricular Function After Left Ventricular Assist Device Implantation Recruiting NCT03552679
31 Molecular Genetics of Heterotaxy and Related Congenital Heart Defects Recruiting NCT02432079
32 Global Congestive Heart Failure Registry Recruiting NCT03078166
33 International Primary Ciliary Dyskinesia Cohort Recruiting NCT03517865
34 Bacteriological Link Between Upper and Lower Airways in Cystic Fibrosis and Primary Ciliary Dyskinesia Recruiting NCT03494894
35 Respiratory Muscle Strength, Exercise Capacity and Physical Activity Levels in Children Primary Ciliary Dyskinesia Recruiting NCT03370029
36 Multiple Breath Washout, a Clinimetric Dataset Recruiting NCT03320382
37 MRI in Cystic Fibrosis and Primary Ciliary Dyskinesia Recruiting NCT03279965
38 Registry for Primary Ciliary Dyskinesia Recruiting NCT03271840
39 High Resolution Micro OCT Imaging Recruiting NCT03256773
40 International Prospective Patient Registry for Primary Ciliary Dyskinesia (PCD) Recruiting NCT02419365
41 Genetics of Primary Ciliary Dyskinesia Recruiting NCT02389049
42 Pathogenesis of Primary Ciliary Dyskinesia (PCD) Lung Disease Recruiting NCT00807482
43 Severe and Transient Hypoxemia During Selective Intra-arterial Chemotherapy for Retinoblastoma in Children: Evaluation of the Right-sided Heart Function. Active, not recruiting NCT03559894
44 Open Lung Strategy in Critically Ill Morbid Obese Patients Active, not recruiting NCT02503241 Not Applicable
45 Long-term Lung Function and Disease Progression in Children With Early Onset Primary Ciliary Dyskinesia Lung Disease Active, not recruiting NCT00722878
46 Evaluating Progression of and Diagnostic Tools for Primary Ciliary Dyskinesia in Children and Adolescents Active, not recruiting NCT00450918
47 Rare Genetic Disorders of the Breathing Airways Active, not recruiting NCT00323167
48 Registry Study on Primary Ciliary Dyskinesia in Chinese Children Not yet recruiting NCT02704455
49 In Vivo Measurements of Nasal Ciliary Beat Frequency by Using Interferometry Not yet recruiting NCT02699177
50 Chest Physiotherapy and Lung Function in Primary Ciliary Dyskinesia Withdrawn NCT01929356 Not Applicable

Search NIH Clinical Center for Dextrocardia

Cochrane evidence based reviews: dextrocardia

Genetic Tests for Dextrocardia

Genetic tests related to Dextrocardia:

# Genetic test Affiliating Genes
1 Dextrocardia 29

Anatomical Context for Dextrocardia

MalaCards organs/tissues related to Dextrocardia:

41
Heart, Lung, Liver, Spleen, Kidney, Skin, Brain

Publications for Dextrocardia

Articles related to Dextrocardia:

(show top 50) (show all 598)
# Title Authors Year
1
Mitral valve replacement via a left thoracotomy in dextrocardia and situs solitus. ( 29338299 )
2018
2
Acute Myocardial Infarction in a Patient with Isolated Dextrocardia. ( 29431312 )
2018
3
Response by Liu and Li to Letter Regarding Article, &amp;quot;Dextrocardia: Why Significant Left Axis Deviation?&amp;quot; ( 29735599 )
2018
4
Quantitation in Dextrocardia on myocardial perfusion imaging: how to perform quantitative analysis using Cedars-Sinai software. ( 29442348 )
2018
5
Late diagnosis of a congenitally corrected transposition of the great arteries discovered at pacemaker implantation in a patient previously diagnosed with dextrocardia and situs solitus. ( 29881577 )
2018
6
Successful Catheter Treatment Using Pre-Operative 3D Organ Model Simulation for Atrial Septal Defect With Dextrocardia and Interrupted Inferior Vena Cava toA theA Superior Vena Cava. ( 29605245 )
2018
7
Hepatoblastoma in a child with dextrocardia and possible histopathological alteration reminiscent of hepatocellular carcinoma after neoadjuvant chemotherapy. ( 29881566 )
2018
8
Transcatheter Aortic Valve Replacement in a Patient with Dextrocardia and Situs Inversus Totalis. ( 29908190 )
2018
9
Electrocardiographic Findings in a Woman With Dextrocardia and Cyanosis. ( 29946689 )
2018
10
Management of scar-related atrial flutter in a patient with dextrocardia, inferior vena cava interruption, and azygos continuation. ( 29424736 )
2018
11
A case of dextrocardia following maternal exposure to generic Fingolimod during the first trimester of pregnancy. ( 29474980 )
2018
12
Letter by Yi-tong Regarding Article, &amp;quot;Dextrocardia: Why Significant Left-Axis Deviation?&amp;quot; ( 29735598 )
2018
13
Successful catheter ablation of a focal atrial tachycardia originating from the coronary sinus ostium in a patient with a history of Fontan conversion and dextrocardia. ( 29688296 )
2018
14
Revisiting Atrioventricular Nodal Ablation and Cardiac Pacing of Atrial Fibrillation in a Patient with Dextrocardia. ( 29666358 )
2018
15
Cryoballoon ablation under transesophageal echocardiographic guidance in dextrocardia. ( 29704566 )
2018
16
Augmented-reality computed tomography-guided transcatheter pacemaker implantation in dextrocardia and congenitally corrected transposition of great arteries. ( 29961937 )
2018
17
Comparing levocardia and dextrocardia in fetuses with heterotaxy syndrome: prenatal features, clinical significance and outcomes. ( 29169330 )
2017
18
Successful percutaneous coronary intervention for an in-stent chronic total occlusion in a patient with dextrocardia: a case report. ( 29145812 )
2017
19
Assessment of coronary artery disease based on coronary flow velocity reserve by transthoracic Doppler echocardiography and coronary computed tomography angiography in a patient with dextrocardia: a case report. ( 29247297 )
2017
20
Review of surgical and anesthetic management for esophageal atresia with tracheoesophageal fistula, unilateral pulmonary agenesis and dextrocardia. ( 28417152 )
2017
21
Unexpected mirror-image dextrocardia in a patient with ST elevation myocardial infarction. ( 28891179 )
2017
22
An unusual cause of 'dextrocardia'. ( 28087601 )
2017
23
Catheter ablation of premature ventricular contractions originating from aortic sinus cusps in a patient with dextrocardia and situs solitus: A case report. ( 29310391 )
2017
24
Surgical challenge in situs inversus with dextrocardia and Lutembacher syndrome. ( 29214824 )
2017
25
Case 4/2017 - Double-Chambered Right Ventricle with Dextrocardia and Hypoxemia Due to Atrial Shunt in a 4-Year-Old Girl. ( 28699979 )
2017
26
Successful Drug-eluting Stent Implantation in a Male Patient with Dextrocardia: A Case Report. ( 29340305 )
2017
27
Prenatal Diagnosis of Dextrocardia with Complex Congenital Heart Disease Using Fetal Intelligent Navigation Echocardiography (FINE) and a Literature Review. ( 28641300 )
2017
28
Aeroembolism in left atrium during catheter ablation of atrial fibrillation in a patient with dextrocardia: a case report and review of the literature. ( 28577360 )
2017
29
Goldenhar Syndrome with Dextrocardia and Right Pulmonary Hypoplasia: An Unusual Association. ( 28377826 )
2017
30
Left side approach for aortic valve replacement in patient with dextrocardia and situs inversus totalis. ( 28983174 )
2017
31
Radiofrequency Pulmonary Vein Isolation in a Patient with Dextrocardia With Situs Inversus Totalis. ( 28462889 )
2017
32
An unusual combination of mirror-image dextrocardia with familial medulloblastoma : Is there a histogenetic relationship? ( 28844926 )
2017
33
Dextrocardia: Why Significant Left-Axis Deviation? ( 29061578 )
2017
34
Dextrocardia With Situs Inversus and Levo-Transposition of Great Vessels. ( 28641729 )
2017
35
Successful left transradial coronary angiography in an elderly patient with dextrocardia and severe aortic stenosis. ( 28529182 )
2017
36
Dextrocardia with asymptomatic right atrial appendage aneurysm: a case report. ( 29152268 )
2017
37
Image Diagnosis: Multivessel Percutaneous Coronary Intervention in Dextrocardia: Success with Usual Techniques in a Case of Mirror-Image Heart. ( 28633731 )
2017
38
Off-pump Coronary Artery Bypass Surgery in a Patient with Dextrocardia and Situs Inversus: Anesthetic, Surgical Consideration and Role of Transesophageal Echocardiography. ( 29184618 )
2017
39
Three-dimensional electroanatomical mapping for non-pulmonary vein foci in a patient with complete situs inversus and dextrocardia. ( 29274801 )
2017
40
Severe aortic stenosis in dextrocardia with situs invertus and anomalous single coronary ostium treated with transcatheter aortic valve replacement. ( 28578896 )
2017
41
Concomitant surgical treatment of coronary artery disease and coarctation of the aorta in a patient with dextrocardia. ( 29281034 )
2017
42
Implantation of VVI pacemaker in a patient with dextrocardia, persistent left superior vena cava, and sick sinus syndrome: A case report. ( 28151908 )
2017
43
Clipping through a mirror: First reported successful MitraClip in a patient with dextrocardia. ( 29087542 )
2017
44
Acute myocardial infarction in a patient with dextrocardia and successful angioplasty. ( 29296253 )
2017
45
Fontan's circulation with dextrocardia, recent pulmonary embolism, and inferior vena cava filter: Anesthetic challenges for urgent hysterectomy. ( 26750698 )
2016
46
Successful Obstetric Outcome in Dextrocardia with Situs Inversus and Moderate Pulmonary Hypertension- Rare Case. ( 27891408 )
2016
47
Valve sparing surgery in an adult patient with dextrocardia and annuloaortic ectasia. ( 27212978 )
2016
48
Robotic atrial septal defect closure and tricuspid annuloplasty in a case of situs inversus totalis with dextrocardia. ( 27344445 )
2016
49
PERFORATED DUODENAL ULCER ASSOCIATED WITH SITUS INVERSUS AND DEXTROCARDIA. ( 27323596 )
2016
50
Repair of Posterior Infarct Ventricular Septal Defect in a Patient with Dextrocardia and Situs Inversus. ( 26785697 )
2016

Variations for Dextrocardia

ClinVar genetic disease variations for Dextrocardia:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 CFAP53 NM_145020.4(CFAP53): c.472A> G (p.Arg158Gly) single nucleotide variant Likely pathogenic rs886037751 GRCh38 Chromosome 18, 50261065: 50261065
2 CFAP53 NM_145020.4(CFAP53): c.472A> G (p.Arg158Gly) single nucleotide variant Likely pathogenic rs886037751 GRCh37 Chromosome 18, 47787435: 47787435
3 CFAP53 NM_145020.4(CFAP53): c.300_473del174 (p.Leu101_Arg158del) deletion Likely pathogenic GRCh38 Chromosome 18, 50261064: 50261237
4 CFAP53 NM_145020.4(CFAP53): c.300_473del174 (p.Leu101_Arg158del) deletion Likely pathogenic GRCh37 Chromosome 18, 47787434: 47787607

Expression for Dextrocardia

Search GEO for disease gene expression data for Dextrocardia.

Pathways for Dextrocardia

Pathways related to Dextrocardia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.28 ACVR2B HES7 NODAL
2 11.08 ACVR2B NODAL
3
Show member pathways
10.65 ACVR2B NODAL

GO Terms for Dextrocardia

Biological processes related to Dextrocardia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 anterior/posterior pattern specification GO:0009952 9.48 ACVR2B NODAL
2 BMP signaling pathway GO:0030509 9.46 ACVR2B NODAL
3 lung development GO:0030324 9.43 ACVR2B NODAL
4 heart development GO:0007507 9.43 ACVR2B DNAI1 NODAL
5 regulation of signal transduction GO:0009966 9.4 ACVR2B NODAL
6 cilium movement GO:0003341 9.37 CFAP53 DNAI1
7 mesoderm development GO:0007498 9.32 ACVR2B HES7
8 gastrulation with mouth forming second GO:0001702 9.16 ACVR2B NODAL
9 positive regulation of activin receptor signaling pathway GO:0032927 8.96 ACVR2B NODAL
10 determination of left/right symmetry GO:0007368 8.92 ACVR2B CFAP53 DNAI1 NODAL

Molecular functions related to Dextrocardia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 motor activity GO:0003774 8.62 DNAI1 MYH7

Sources for Dextrocardia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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