MCID: DXT001
MIFTS: 54

Dextrocardia

Categories: Cardiovascular diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Dextrocardia

MalaCards integrated aliases for Dextrocardia:

Name: Dextrocardia 12 77 54 60 30 6 45 15
Heart Predominantly in Right Hemithorax 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9565
MeSH 45 D003914
NCIt 51 C84669
SNOMED-CT 69 27637000
ICD10 34 Q24.0
MESH via Orphanet 46 D003914
ICD10 via Orphanet 35 Q24.0
UMLS via Orphanet 75 C0011813 C0265863
Orphanet 60 ORPHA1666
UMLS 74 C0011813

Summaries for Dextrocardia

NIH Rare Diseases : 54 Dextrocardia is a condition in which the heart is located in the right side of the chest instead of the left. It is usually present from birth (congenital). There are several types of dextrocardia.  The simplest type occurs when the shape and structure of the heart is a mirror image of a normal heart.  Other types of dextrocardia may involve defects of the walls of the heart, nearby blood vessels, or other organs in the abdomen. Chest X-raxys and echocardiograms can be used to determine which type of dextrocardia is present. 

MalaCards based summary : Dextrocardia, also known as heart predominantly in right hemithorax, is related to dextrocardia with situs inversus and situs inversus. An important gene associated with Dextrocardia is CFAP53 (Cilia And Flagella Associated Protein 53), and among its related pathways/superpathways are Mesodermal Commitment Pathway and TGF-beta signaling pathway (KEGG). The drugs Spironolactone and Riociguat have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and kidney, and related phenotypes are t-wave inversion and situs inversus totalis

Wikipedia : 77 Dextrocardia (from Latin dexter, meaning "right," and Greek kardia, meaning "heart") is a rare... more...

Related Diseases for Dextrocardia

Diseases related to Dextrocardia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 165)
# Related Disease Score Top Affiliating Genes
1 dextrocardia with situs inversus 33.3 CFAP53 HES7 NODAL
2 situs inversus 31.0 CFAP53 DNAI1 NODAL
3 heterotaxy 29.6 ACVR2B CFAP53 NODAL
4 visceral heterotaxy 29.1 ACVR2B CFAP53 DNAI1 NODAL
5 short stature wormian bones dextrocardia 12.4
6 dextrocardia with unusual facies and microphthalmia 12.3
7 heterotaxy, visceral, 1, x-linked 11.9
8 kartagener syndrome 11.7
9 stratton-parker syndrome 11.7
10 ciliary dyskinesia, primary, 1 11.7
11 levocardia 11.4
12 heterotaxy, visceral, 5, autosomal 11.4
13 pagod syndrome 11.3
14 van allen myhre syndrome 11.1
15 marden-walker syndrome 11.0
16 heterotaxy, visceral, 4, autosomal 11.0
17 intellectual disability - athetosis - microphthalmia 11.0
18 myocardial infarction 10.5
19 double discordia 10.4
20 transposition of the great arteries 10.4
21 acute myocardial infarction 10.3
22 poland syndrome 10.3
23 heart disease 10.3
24 ventricular septal defect 10.3
25 atrial fibrillation 10.3
26 atrial heart septal defect 10.2
27 mitral valve stenosis 10.2
28 double outlet right ventricle 10.2
29 congenitally corrected transposition of the great arteries 10.2
30 tetralogy of fallot 10.2
31 arteries, anomalies of 10.1
32 progressive familial heart block, type ia 10.1
33 lung agenesis 10.1
34 coronary artery anomaly 10.1
35 bronchiectasis 10.1
36 atrial standstill 1 10.1
37 transposition of the great arteries, dextro-looped 1 10.1
38 tricuspid atresia 10.0
39 sinusitis 10.0
40 sick sinus syndrome 10.0
41 aortic coarctation 10.0
42 moebius syndrome 10.0
43 atrioventricular septal defect 10.0
44 single ventricular heart 10.0
45 lutembacher's syndrome 10.0
46 ischemia 10.0
47 charlie m syndrome 10.0
48 total anomalous pulmonary venous return 1 9.9
49 cleft palate, isolated 9.9
50 lipomatosis, multiple 9.9

Graphical network of the top 20 diseases related to Dextrocardia:



Diseases related to Dextrocardia

Symptoms & Phenotypes for Dextrocardia

Human phenotypes related to Dextrocardia:

60 33 (show all 27)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 t-wave inversion 60 33 hallmark (90%) Very frequent (99-80%) HP:0010872
2 situs inversus totalis 60 33 frequent (33%) Frequent (79-30%) HP:0001696
3 congenital malformation of the great arteries 60 33 frequent (33%) Frequent (79-30%) HP:0011603
4 intestinal malrotation 60 33 occasional (7.5%) Occasional (29-5%) HP:0002566
5 abnormality of the spleen 60 33 occasional (7.5%) Occasional (29-5%) HP:0001743
6 abnormality of the pulmonary artery 60 33 occasional (7.5%) Occasional (29-5%) HP:0004414
7 abnormality of the ureter 60 33 occasional (7.5%) Occasional (29-5%) HP:0000069
8 abnormal lung lobation 60 33 occasional (7.5%) Occasional (29-5%) HP:0002101
9 abnormal renal morphology 60 33 occasional (7.5%) Occasional (29-5%) HP:0012210
10 abnormal reproductive system morphology 60 33 occasional (7.5%) Occasional (29-5%) HP:0012243
11 abnormality of abdominal situs 60 33 occasional (7.5%) Occasional (29-5%) HP:0011620
12 abnormal pulmonary situs morphology 33 occasional (7.5%) HP:0011615
13 hydrocephalus 60 33 very rare (1%) Very rare (<4-1%) HP:0000238
14 global developmental delay 60 33 very rare (1%) Very rare (<4-1%) HP:0001263
15 webbed neck 60 33 very rare (1%) Very rare (<4-1%) HP:0000465
16 abnormality of the foot 60 33 very rare (1%) Very rare (<4-1%) HP:0001760
17 congenital hip dislocation 60 33 very rare (1%) Very rare (<4-1%) HP:0001374
18 abnormality of the ribs 60 33 very rare (1%) Very rare (<4-1%) HP:0000772
19 preauricular skin tag 60 33 very rare (1%) Very rare (<4-1%) HP:0000384
20 neuroblastoma 60 33 very rare (1%) Very rare (<4-1%) HP:0003006
21 meckel diverticulum 60 33 very rare (1%) Very rare (<4-1%) HP:0002245
22 pancreatic hypoplasia 60 33 very rare (1%) Very rare (<4-1%) HP:0002594
23 aplasia/hypoplasia of the ear 60 33 very rare (1%) Very rare (<4-1%) HP:0008771
24 dextrocardia 60 Obligate (100%)
25 abnormal ekg 60 Very frequent (99-80%)
26 abnormal heart morphology 60 Very frequent (99-80%)
27 abnormality of pulmonary situs 60 Occasional (29-5%)

MGI Mouse Phenotypes related to Dextrocardia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.8 ACVR2B CFAP53 CTC1 DNAI1 HES7 NODAL
2 cardiovascular system MP:0005385 9.77 ACVR2B CFAP53 DNAI1 NODAL STRA6
3 embryo MP:0005380 9.72 ACVR2B CFAP53 HES7 NODAL STRA6
4 immune system MP:0005387 9.63 ACVR2B CFAP53 CTC1 DNAI1 NODAL STRA6
5 respiratory system MP:0005388 9.26 ACVR2B CFAP53 DNAI1 NODAL
6 skeleton MP:0005390 9.02 ACVR2B DNAI1 HES7 NODAL STRA6

Drugs & Therapeutics for Dextrocardia

Drugs for Dextrocardia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 58)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
2
Riociguat Approved Phase 4 625115-55-1
3
Sodium Citrate Approved, Investigational Phase 4 68-04-2
4
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
5 Kava Approved, Investigational, Nutraceutical Phase 4 9000-38-8
6
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
7 Sodium Channel Blockers Phase 4
8 Mineralocorticoids Phase 4
9 Hormones Phase 4
10 Hormone Antagonists Phase 4
11 Natriuretic Agents Phase 4,Phase 3
12 Diuretics, Potassium Sparing Phase 4
13 diuretics Phase 4
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
15 Mineralocorticoid Receptor Antagonists Phase 4
16 Vasodilator Agents Phase 4,Phase 3,Phase 2,Not Applicable
17 Natriuretic Peptide, Brain Phase 4,Phase 3
18 Endothelin Receptor Antagonists Phase 4
19 Phosphodiesterase Inhibitors Phase 4,Phase 2
20 Sildenafil Citrate Phase 4 171599-83-0
21 Citrate Phase 4
22 Phosphodiesterase 5 Inhibitors Phase 4
23
Nitroglycerin Approved, Investigational Phase 3 55-63-0 4510
24
Ivacaftor Approved Phase 2 873054-44-5 16220172
25
Ambrisentan Approved, Investigational Phase 2 177036-94-1 6918493
26
Simvastatin Approved Phase 2 79902-63-9 54454
27
Aspirin Approved, Vet_approved Phase 2 50-78-2 2244
28 Simendan Investigational Phase 2 131741-08-7
29 Protective Agents Phase 2,Not Applicable
30 Peripheral Nervous System Agents Phase 2,Not Applicable
31 Pharmaceutical Solutions Phase 2
32 Cardiotonic Agents Phase 2
33 Phosphodiesterase 3 Inhibitors Phase 2
34 Antihypertensive Agents Phase 2
35 Platelet Aggregation Inhibitors Phase 2
36 Antipyretics Phase 2
37 Cyclooxygenase Inhibitors Phase 2
38 Analgesics Phase 2
39 Fibrinolytic Agents Phase 2
40 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 2
41 Anti-Inflammatory Agents Phase 2
42 Antirheumatic Agents Phase 2
43 Antimetabolites Phase 2
44 Lipid Regulating Agents Phase 2
45 Anticholesteremic Agents Phase 2
46 Hypolipidemic Agents Phase 2
47 Anti-Inflammatory Agents, Non-Steroidal Phase 2
48 Analgesics, Non-Narcotic Phase 2
49
Nitric Oxide Approved ,Not Applicable 10102-43-9 145068
50 Autonomic Agents ,Not Applicable

Interventional clinical trials:

(show top 50) (show all 59)
# Name Status NCT ID Phase Drugs
1 Effects of Spironolactone on Collagen Metabolism in Patients With Pulmonary Arterial Hypertension Unknown status NCT01468571 Phase 4 Spironolactone;Placebo
2 Water Immersion in Right-Sided Heart Failure: A Pilot Study Completed NCT00654264 Phase 4
3 Spironolactone Therapy in Chronic Stable Right HF Trial Recruiting NCT03344159 Phase 4 Spironolactone;Placebo
4 Heterotopic Implantation Of the Edwards-Sapien Transcatheter Aortic Valve in the Inferior VEna Cava for the Treatment of Severe Tricuspid Regurgitation (HOVER) Recruiting NCT02339974 Phase 4
5 Riociguat rEplacing PDE-5i Therapy evaLuated Against Continued PDE-5i thErapy Recruiting NCT02891850 Phase 4 Adempas (Riociguat, BAY63-2521);Sildenafil;Tadalafil
6 A Study Comparing Blood Flow and Clinical and Safety Effects of the Addition of Natrecor (Nesiritide), Placebo or Intravenous Nitroglycerin to Standard Care for the Treatment of Worsening Congestive Heart Failure. Completed NCT00270374 Phase 3 nesiritide
7 Ketones in Heart Failure - Effects on Cardiac Efficiency Completed NCT03073356 Phase 2
8 Acute Effects of Inorganic Nitrite on Cardiovascular Hemodynamics in Heart Failure With Preserved Ejection Fraction Completed NCT01932606 Phase 2 Nitrite;Saline Placebo for Nitrite
9 Clearing Lungs With ENaC Inhibition in Primary Ciliary Dyskinesia Completed NCT02871778 Phase 2 VX-371;Hypertonic Saline;Placebo (0.17% saline);Ivacaftor
10 Open-Label Rollover Study of Levosimendan in PH-HFpEF Patients Recruiting NCT03624010 Phase 2 Levosimendan 2.5 mg/ml Injectable Solution
11 Long-term Ambrisentan Extension Study for Pediatric Patients Who Participated in AMB112529 Recruiting NCT01342952 Phase 2 Ambrisentan
12 Ambrisentan in Single Ventricle Active, not recruiting NCT02080637 Phase 2 Ambrisentan
13 Efficacy and Safety of Ambrisentan in Children 8-18yrs Suspended NCT01332331 Phase 2 Ambrisentan - low dose;Ambrisentan - high dose
14 A Study of Aspirin and Simvastatin in Pulmonary Arterial Hypertension Terminated NCT00384865 Phase 2 Simvastatin;Aspirin;Placebo
15 Behaviour of Tricuspid Valve Regurgitation in Volume and/or Pressure Loaded Right Heart Unknown status NCT01444222
16 Early Detection and Characterization of Primary Ciliary Dyskinesia Unknown status NCT01070914
17 Screening for Primary Ciliary Dyskinesia Using Nasal Nitric Oxide Unknown status NCT00739817
18 Comparison of On-line and Off-line Measurements of Exhaled Nitric Oxide (NO) Unknown status NCT00686309
19 Transcatheter Valve Implantation in Patients With Dysfunctional Left and Right Sided Heart Valves Completed NCT02119442 Not Applicable
20 Non-invasive Assessment of Liver Stiffness/Fibrosis by Transient Elastography (Fibroscan) in Patients With Left and/or Right Sided Heart Failure Completed NCT00777725
21 Evaluation of Monitoring TECHNOlogies in the PERI-OPerative Care of Cardiac Surgical Patients Completed NCT02658006
22 Portal Flow Pulsatility as a Risk Factor for Acute Kidney Injury After Cardiac Surgery Completed NCT02831907
23 Pilot Chart Review Study Of Sitaxentan Sodium (Thelin) In Patients With Pulmonary Arterial Hypertension (PAH) Completed NCT01445873 Sitaxentan sodium
24 Respiratory Muscle Strength, Exercise Capacity and Physical Activity Levels in Children Primary Ciliary Dyskinesia Completed NCT03370029
25 NIOX VERO Nasal Application in Primary Ciliary Dyskinesia Completed NCT02622061
26 Otolith Function in Patients With Primary Ciliary Dyskinesia Completed NCT01246258
27 Inflammatory and Microbiologic Markers in Sputum: Comparing Cystic Fibrosis With Primary Ciliary Dyskinesia Completed NCT01155115 Not Applicable
28 Diagnosis of Primary Ciliary Dyskinesia Completed NCT00783887
29 Dyskinesia, Heterotaxy and Congenital Heart Disease Completed NCT00608556
30 Genetic Disorders of Mucociliary Clearance in Nontuberculous Mycobacterial Lung Disease Completed NCT00368446
31 Rare Genetic Disorders of the Breathing Airways Completed NCT00323167
32 Genetic Study of Patients With Primary Ciliary Dyskinesia Completed NCT00005650
33 Pulmonary Endarterectomy Guided by CT Scanning for Patients With Chronic Thromboembolic Pulmonary Hypertension----PEACT Recruiting NCT03795740 Not Applicable
34 Imaging Control Study, 3D Echo, MR and RHC. Recruiting NCT02198456
35 Serial Multiparametric Evaluation of Right Ventricular Function After Left Ventricular Assist Device Implantation Recruiting NCT03552679
36 Molecular Genetics of Heterotaxy and Related Congenital Heart Defects Recruiting NCT02432079
37 WGS of Korean Idiopathic Bronchiectasis Recruiting NCT03809091
38 PCD New Gene Discovery Recruiting NCT03801395
39 Utility of PCD Diagnostics to Improve Clinical Care Recruiting NCT03704207 Not Applicable
40 Swiss Primary Ciliary Dyskinesia Registry Recruiting NCT03606200
41 International Primary Ciliary Dyskinesia Cohort Recruiting NCT03517865
42 Bacteriological Link Between Upper and Lower Airways in Cystic Fibrosis and Primary Ciliary Dyskinesia Recruiting NCT03494894
43 Multiple Breath Washout, a Clinimetric Dataset Recruiting NCT03320382
44 MRI in Cystic Fibrosis and Primary Ciliary Dyskinesia Recruiting NCT03279965
45 Registry for Primary Ciliary Dyskinesia Recruiting NCT03271840
46 High Resolution Micro OCT Imaging Recruiting NCT03256773
47 International Prospective Patient Registry for Primary Ciliary Dyskinesia (PCD) Recruiting NCT02419365
48 Pathogenesis of Primary Ciliary Dyskinesia (PCD) Lung Disease Recruiting NCT00807482
49 Long-term Lung Function and Disease Progression in Children With Early Onset Primary Ciliary Dyskinesia Lung Disease Recruiting NCT00722878
50 Evaluating Progression of and Diagnostic Tools for Primary Ciliary Dyskinesia in Children and Adolescents Recruiting NCT00450918

Search NIH Clinical Center for Dextrocardia

Cochrane evidence based reviews: dextrocardia

Genetic Tests for Dextrocardia

Genetic tests related to Dextrocardia:

# Genetic test Affiliating Genes
1 Dextrocardia 30

Anatomical Context for Dextrocardia

MalaCards organs/tissues related to Dextrocardia:

42
Heart, Lung, Kidney, Liver, Spleen, Skin, Brain

Publications for Dextrocardia

Articles related to Dextrocardia:

(show top 50) (show all 641)
# Title Authors Year
1
His-bundle pacing in a patient with dextrocardia, severe systolic dysfunction, and complete atrioventricular block. ( 30891412 )
2019
2
Transcatheter Aortic Valve Replacement in a Patient With Dextrocardia and Situs Inversus Totalis. ( 29908190 )
2019
3
Successful Heart Transplantation in Two Infants With Dextrocardia-Heterotaxy Syndrome. ( 30081023 )
2019
4
Partition of Common Atrioventricular Valve in a Patient With Dextrocardia and Univentricular Circulation. ( 30273646 )
2019
5
Transcatheter atrioventricular valve-in-valve implantation for Fontan circulation and dextrocardia. ( 30312393 )
2019
6
Comparison of Morphologic Findings in Patients with Dextrocardia with Situs Solitus vs Situs Inversus: a Retrospective Study. ( 30334087 )
2019
7
Implantation of a completely right sided subcutaneous cardioverter-defibrillator in a patient with situs inversus dextrocardia. ( 30468861 )
2019
8
Catheter ablation of supraventricular tachycardia in patients with dextrocardia and situs inversus. ( 30661266 )
2019
9
Coronary angioplasty in an adult with dextrocardia and single coronary artery with the right coronary artery originating from the left anterior descending artery. ( 30707111 )
2019
10
Right-Sided Subcutaneous Implantable Cardioverter Defibrillator System Implantation in a Patient with Complex Congenital Heart Disease and Dextrocardia: A Case Report and Literature Review. ( 30867968 )
2019
11
Dextrocardia with complete AV block and the implantation of a temporary pacemaker before cesarean section: A case report. ( 31027067 )
2019
12
Transradial Approach to Coronary Angiography and Percutaneous Intervention in Patients With Dextrocardia. ( 31034439 )
2019
13
SPECT myocardial perfusion imaging in patients with Dextrocardia. ( 31062220 )
2019
14
Percutaneous coronary intervention for left main coronary artery stenosis in a patient with dextrocardia. ( 31087254 )
2019
15
Acute myocardial infarction in dextrocardia - A diagnostic and therapeutic challenge. Can dextrocardia be a risk factor? ( 30279853 )
2018
16
Acute Myocardial Infarction in a Patient with Isolated Dextrocardia. ( 29431312 )
2018
17
Trans-aortic pulmonary vein isolation using magnetic navigation system for paroxysmal atrial fibrillation in a patient with dextrocardia, situs inversus, and inferior vena cava continuity with azygos vein. ( 30327707 )
2018
18
Late diagnosis of a congenitally corrected transposition of the great arteries discovered at pacemaker implantation in a patient previously diagnosed with dextrocardia and situs solitus. ( 29881577 )
2018
19
Severe aortic stenosis in dextrocardia with situs invertus and anomalous single coronary ostium treated with transcatheter aortic valve replacement. ( 28578896 )
2018
20
Prenatal Diagnosis of Dextrocardia with Complex Congenital Heart Disease Using Fetal Intelligent Navigation Echocardiography (FINE) and a Literature Review. ( 28641300 )
2018
21
Surgical challenge in situs inversus with dextrocardia and Lutembacher syndrome. ( 29214824 )
2018
22
Assessment of coronary artery disease based on coronary flow velocity reserve by transthoracic Doppler echocardiography and coronary computed tomography angiography in a patient with dextrocardia: a case report. ( 29247297 )
2018
23
Three-dimensional electroanatomical mapping for non-pulmonary vein foci in a patient with complete situs inversus and dextrocardia. ( 29274801 )
2018
24
Concomitant surgical treatment of coronary artery disease and coarctation of the aorta in a patient with dextrocardia. ( 29281034 )
2018
25
Mitral valve replacement via a left thoracotomy in dextrocardia and situs solitus. ( 29338299 )
2018
26
Management of scar-related atrial flutter in a patient with dextrocardia, inferior vena cava interruption, and azygos continuation. ( 29424736 )
2018
27
Quantitation in Dextrocardia on myocardial perfusion imaging: how to perform quantitative analysis using Cedars-Sinai software. ( 29442348 )
2018
28
A case of dextrocardia following maternal exposure to generic Fingolimod during the first trimester of pregnancy. ( 29474980 )
2018
29
Successful Catheter Treatment Using Pre-Operative 3D Organ Model Simulation for Atrial Septal Defect With Dextrocardia and Interrupted Inferior Vena Cava to the Superior Vena Cava. ( 29605245 )
2018
30
Revisiting Atrioventricular Nodal Ablation and Cardiac Pacing of Atrial Fibrillation in a Patient with Dextrocardia. ( 29666358 )
2018
31
Successful catheter ablation of a focal atrial tachycardia originating from the coronary sinus ostium in a patient with a history of Fontan conversion and dextrocardia. ( 29688296 )
2018
32
Cryoballoon ablation under transesophageal echocardiographic guidance in dextrocardia. ( 29704566 )
2018
33
Letter by Yi-tong Regarding Article, "Dextrocardia: Why Significant Left-Axis Deviation?" ( 29735598 )
2018
34
Response by Liu and Li to Letter Regarding Article, "Dextrocardia: Why Significant Left Axis Deviation?" ( 29735599 )
2018
35
Hepatoblastoma in a child with dextrocardia and possible histopathological alteration reminiscent of hepatocellular carcinoma after neoadjuvant chemotherapy. ( 29881566 )
2018
36
Electrocardiographic Findings in a Woman With Dextrocardia and Cyanosis. ( 29946689 )
2018
37
Augmented-reality computed tomography-guided transcatheter pacemaker implantation in dextrocardia and congenitally corrected transposition of great arteries. ( 29961937 )
2018
38
Senning Procedure for Transposition of the Great Arteries in a Patient with Situs Inversus Totalis and Dextrocardia. ( 30173681 )
2018
39
d-transposition of great arteries, dextrocardia with aberrant origin of right subclavian artery from pulmonary artery. ( 30206995 )
2018
40
Subcutaneous implantable defibrillator in dextrocardia secondary to Lobectomy. ( 30214751 )
2018
41
Transcatheter aortic valve implantation for severe aortic stenosis in dextrocardia with situs inversus using a self-expanding aortic valve. ( 30279894 )
2018
42
Persistent dextrocardia after adult orthotopic heart transplantation in a patient with complex congenital heart disease. ( 30528511 )
2018
43
Just flip it!-CRT implantation in a patient with dextrocardia and situs inversus totalis. ( 30555613 )
2018
44
Atrioventricular Canal and Dextrocardia: A Case Report with Implications for Community-Based Providers. ( 30567810 )
2018
45
Rare case of septum primum malposition defect in dextrocardia and situs inversus totalis without heterotaxy syndrome. ( 30585568 )
2018
46
Doing the "right" thing: Cardiac transplantation in patients with dextrocardia. ( 30630604 )
2018
47
Acute myocardial infarction in a patient with dextrocardia and successful angioplasty. ( 29296253 )
2017
48
Orthotropic heart transplantation for adult congenital heart disease: a case with heterotaxy and dextrocardia. ( 26162269 )
2017
49
Robotic atrial septal defect closure and tricuspid annuloplasty in a case of situs inversus totalis with dextrocardia. ( 27344445 )
2017
50
Acute coronary syndrome in dextrocardia and situs inversus patient. ( 27677448 )
2017

Variations for Dextrocardia

ClinVar genetic disease variations for Dextrocardia:

6 (show all 14)
# Gene Variation Type Significance SNP ID Assembly Location
1 CFAP53 NM_145020.4(CFAP53): c.472A> G (p.Arg158Gly) single nucleotide variant Likely pathogenic rs886037751 GRCh38 Chromosome 18, 50261065: 50261065
2 CFAP53 NM_145020.4(CFAP53): c.472A> G (p.Arg158Gly) single nucleotide variant Likely pathogenic rs886037751 GRCh37 Chromosome 18, 47787435: 47787435
3 CFAP53 NM_145020.4(CFAP53): c.300_473del174 (p.Leu101_Arg158del) deletion Likely pathogenic rs1555672928 GRCh38 Chromosome 18, 50261064: 50261237
4 CFAP53 NM_145020.4(CFAP53): c.300_473del174 (p.Leu101_Arg158del) deletion Likely pathogenic rs1555672928 GRCh37 Chromosome 18, 47787434: 47787607
5 ROCK2 NM_004850.4(ROCK2): c.3724C> T (p.Gln1242Ter) single nucleotide variant Uncertain significance GRCh37 Chromosome 2, 11332802: 11332802
6 ROCK2 NM_004850.4(ROCK2): c.3724C> T (p.Gln1242Ter) single nucleotide variant Uncertain significance GRCh38 Chromosome 2, 11192676: 11192676
7 ZFYVE16 NM_001349434.1(ZFYVE16): c.1798G> A (p.Asp600Asn) single nucleotide variant Uncertain significance GRCh37 Chromosome 5, 79734302: 79734302
8 ZFYVE16 NM_001349434.1(ZFYVE16): c.1798G> A (p.Asp600Asn) single nucleotide variant Uncertain significance GRCh38 Chromosome 5, 80438483: 80438483
9 ZFYVE16 NM_001349434.1(ZFYVE16): c.3755G> C (p.Gly1252Ala) single nucleotide variant Uncertain significance GRCh37 Chromosome 5, 79752344: 79752344
10 ZFYVE16 NM_001349434.1(ZFYVE16): c.3755G> C (p.Gly1252Ala) single nucleotide variant Uncertain significance GRCh38 Chromosome 5, 80456525: 80456525
11 RAI2 NM_021785.4(RAI2): c.712G> A (p.Val238Ile) single nucleotide variant Uncertain significance GRCh37 Chromosome X, 17819419: 17819419
12 RAI2 NM_021785.4(RAI2): c.712G> A (p.Val238Ile) single nucleotide variant Uncertain significance GRCh38 Chromosome X, 17801299: 17801299
13 SUPT16H NM_007192.3(SUPT16H): c.956-1G> A single nucleotide variant Uncertain significance GRCh37 Chromosome 14, 21834689: 21834689
14 SUPT16H NM_007192.3(SUPT16H): c.956-1G> A single nucleotide variant Uncertain significance GRCh38 Chromosome 14, 21366530: 21366530

Expression for Dextrocardia

Search GEO for disease gene expression data for Dextrocardia.

Pathways for Dextrocardia

Pathways related to Dextrocardia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.28 ACVR2B HES7 NODAL
2 11.13 ACVR2B NODAL
3
Show member pathways
10.65 ACVR2B NODAL

GO Terms for Dextrocardia

Biological processes related to Dextrocardia according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 kidney development GO:0001822 9.51 ACVR2B STRA6
2 anterior/posterior pattern specification GO:0009952 9.49 ACVR2B NODAL
3 BMP signaling pathway GO:0030509 9.48 ACVR2B NODAL
4 regulation of signal transduction GO:0009966 9.46 ACVR2B NODAL
5 mesoderm development GO:0007498 9.43 ACVR2B HES7
6 lung development GO:0030324 9.43 ACVR2B NODAL STRA6
7 cilium movement GO:0003341 9.4 CFAP53 DNAI1
8 gastrulation with mouth forming second GO:0001702 9.37 ACVR2B NODAL
9 digestive tract morphogenesis GO:0048546 9.32 NODAL STRA6
10 heart development GO:0007507 9.26 ACVR2B DNAI1 NODAL STRA6
11 positive regulation of activin receptor signaling pathway GO:0032927 9.16 ACVR2B NODAL
12 determination of left/right symmetry GO:0007368 8.92 ACVR2B CFAP53 DNAI1 NODAL

Sources for Dextrocardia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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