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MCID: DXT002
MIFTS: 43

Dextrocardia with Situs Inversus

Categories: Cardiovascular diseases, Fetal diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Drugs
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Aliases & Classifications for Dextrocardia with Situs Inversus

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MalaCards integrated aliases for Dextrocardia with Situs Inversus:

Name: Dextrocardia with Situs Inversus 20
Situs Inversus Totalis 20 58 29 6
Complete Situs Inversus Viscerum 58
Complete Situs Inversus 58
Situs Inversus 58

Characteristics:

Orphanet epidemiological data:

58
situs inversus totalis
Inheritance: Autosomal dominant,Autosomal recessive,Not applicable;

Classifications:

MalaCards categories:
Global: Rare diseases Fetal diseases
Anatomical: Cardiovascular diseases
See all MalaCards categories (disease lists)
ICD10: 33
Orphanet: 58  
Rare cardiac malformations
Developmental anomalies during embryogenesis


External Ids:

ICD10 via Orphanet 33 Q89.3
UMLS via Orphanet 71 C0037221
Orphanet 58 ORPHA101063
Sources

Summaries for Dextrocardia with Situs Inversus

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GARD : 20 Dextrocardia with situs inversus is a condition that is characterized by abnormal positioning of the heart and other internal organs. In people affected by dextrocardia, the tip of the heart points towards the right side of the chest instead of the left side. Situs inversus refers to the mirror-image reversal of the organs in the chest and abdominal cavity. Some affected people have no obvious signs or symptoms. However, a small percentage of people also have congenital heart defects, usually transposition of the great vessels. Dextrocardia with situs inversus can also be associated with primary ciliary dyskinesia (also known as Kartagener syndrome ). Treatment typically depends on the heart or physical problems the person may have in addition to dextrocardia with situs inversus.

MalaCards based summary : Dextrocardia with Situs Inversus, also known as situs inversus totalis, is related to heterotaxy and dextrocardia. An important gene associated with Dextrocardia with Situs Inversus is PKD1L1 (Polycystin 1 Like 1, Transient Receptor Potential Channel Interacting). The drugs Nitric Oxide and Respiratory System Agents have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and liver, and related phenotypes are embryo and growth/size/body region

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Related Diseases for Dextrocardia with Situs Inversus

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Diseases related to Dextrocardia with Situs Inversus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 545)
# Related Disease Score Top Affiliating Genes
1 heterotaxy 31.7 PKD1L1 NODAL MMP21 CFAP53
2 dextrocardia 31.4 NODAL HES7 CFAP53
3 kartagener syndrome 31.4 PKD1L1 MNS1 DNAH9 CFAP53 CCDC103
4 right atrial isomerism 31.0 NODAL DNAH9 CITED2 ANKS3
5 dextro-looped transposition of the great arteries 30.9 PKD1L1 NODAL
6 situs inversus 30.8 MNS1 DNAH9 CFAP53 CFAP52 CCDC103
7 visceral heterotaxy 30.3 PKD1L1 NODAL NME7 MNS1 MMP21 DNAH9
8 heart septal defect 29.7 NODAL CITED2
9 primary ciliary dyskinesia 28.1 PKD1L1 NODAL NME7 MNS1 MMP21 DNAH9
10 ciliary dyskinesia, primary, 1 11.7
11 retinitis pigmentosa 82 with or without situs inversus 11.7
12 ciliary dyskinesia, primary, 3 11.7
13 ciliary dyskinesia, primary, 9 11.7
14 ciliary dyskinesia, primary, 7 11.7
15 ciliary dyskinesia, primary, 28 11.7
16 ciliary dyskinesia, primary, 5 11.7
17 ciliary dyskinesia, primary, 18 11.7
18 ciliary dyskinesia, primary, 23 11.7
19 ciliary dyskinesia, primary, 20 11.6
20 ciliary dyskinesia, primary, 40 11.6
21 ciliary dyskinesia, primary, 10 11.6
22 ciliary dyskinesia, primary, 16 11.6
23 ciliary dyskinesia, primary, 17 11.6
24 ciliary dyskinesia, primary, 19 11.6
25 ciliary dyskinesia, primary, 25 11.6
26 ciliary dyskinesia, primary, 26 11.6
27 ciliary dyskinesia, primary, 27 11.6
28 ciliary dyskinesia, primary, 35 11.6
29 ciliary dyskinesia, primary, 29 11.6
30 agnathia-otocephaly complex 11.6
31 ciliary dyskinesia, primary, 2 11.6
32 ciliary dyskinesia, primary, 11 11.6
33 ciliary dyskinesia, primary, 12 11.6
34 ciliary dyskinesia, primary, 13 11.6
35 ciliary dyskinesia, primary, 14 11.6
36 ciliary dyskinesia, primary, 15 11.6
37 ciliary dyskinesia, primary, 21 11.6
38 ciliary dyskinesia, primary, 22 11.6
39 ciliary dyskinesia, primary, 30 11.6
40 ciliary dyskinesia, primary, 38 11.6
41 ciliary dyskinesia, primary, 39 11.6
42 ciliary dyskinesia, primary, 43 11.6
43 ciliary dyskinesia, primary, 44 11.6
44 heterotaxy, visceral, 1, x-linked 11.5
45 ciliary dyskinesia, primary, 36, x-linked 11.5
46 ciliary dyskinesia, primary, 24 11.5
47 ciliary dyskinesia, primary, 37 11.5
48 hypoglossia with situs inversus 11.5
49 ciliary dyskinesia, primary, 4 11.5
50 situs inversus totalis with cystic dysplasia of kidneys and pancreas 11.4

Graphical network of the top 20 diseases related to Dextrocardia with Situs Inversus:



Diseases related to Dextrocardia with Situs Inversus
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Symptoms & Phenotypes for Dextrocardia with Situs Inversus

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MGI Mouse Phenotypes related to Dextrocardia with Situs Inversus:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.7 ANKS3 CFAP53 CITED2 HES7 NME7 NODAL
2 growth/size/body region MP:0005378 9.61 ANKS3 CFAP53 CITED2 HES7 MMP21 MNS1
3 respiratory system MP:0005388 9.23 ANKS3 CFAP53 CITED2 MMP21 MNS1 NME7
Sources

Drugs & Therapeutics for Dextrocardia with Situs Inversus

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Drugs for Dextrocardia with Situs Inversus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nitric Oxide Approved Phase 3 10102-43-9 145068
2 Respiratory System Agents Phase 3
3 Anti-Asthmatic Agents Phase 3
4 Vasodilator Agents Phase 3
5 Antioxidants Phase 3
6 Protective Agents Phase 3
7 Neurotransmitter Agents Phase 3
8 Endothelium-Dependent Relaxing Factors Phase 3
9 Bronchodilator Agents Phase 3
10
Mechlorethamine Approved, Investigational 51-75-2 4033
11 3-Iodobenzylguanidine

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomised Controlled Trial of Nitric Oxide Administration During Cardiopulmonary Bypass in Infants Undergoing Arterial Switch Operation for Repair of Transposition of the Great Arteries Recruiting NCT03661385 Phase 3 Nitric Oxide
2 Characterization of the Cardiac Reinnervation of Patients With Transposition of the Great Arteries Long After Repair With the Arterial Switch Operation. Correlation With Electrocardiographic and Exercise Test Parameters Unknown status NCT03469843
3 Ciliary Dysfunction as an Underlying Etiology Linking Primary Ciliary Dyskinesia With Heterotaxy and Complex Congenital Heart Disease Completed NCT00608556
4 MRI Study After Arterial Switch Operation in Patients With Transposition of the Great Arteries Completed NCT01916499
5 Late Function After Surgery for Transposition of the Great Arteries Completed NCT03078413
6 Transposition of the Great Arteries: Prenatal Anatomical and Hemodynamic Findings Associated With Perinatal Outcomes Recruiting NCT03771534 Oxygen gas
7 A Retrospective Comparison of the Efficacy and Safety of Celsior® in Pediatric Cardiac Surgery for Transposition of the Great Vessels Recruiting NCT04616222 CELSIOR® group;Saint-Thomas group
8 Clinical Impact of Rapid Prototyping 3D Models of Congenital Heart Disease on Surgical Management Withdrawn NCT04788082

Search NIH Clinical Center for Dextrocardia with Situs Inversus

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Genetic Tests for Dextrocardia with Situs Inversus

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Genetic tests related to Dextrocardia with Situs Inversus:

# Genetic test Affiliating Genes
1 Situs Inversus Totalis 29
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Anatomical Context for Dextrocardia with Situs Inversus

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MalaCards organs/tissues related to Dextrocardia with Situs Inversus:

40
Heart, Kidney, Liver, Colon, Pancreas, Appendix, Lung
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Publications for Dextrocardia with Situs Inversus

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Articles related to Dextrocardia with Situs Inversus:

(show top 50) (show all 900)
# Title Authors PMID Year
1
Bi-allelic Mutations in PKD1L1 Are Associated with Laterality Defects in Humans. 61 6
27616478 2016
2
Robotic-assisted total gastrectomy in a patient with gastric cancer associated with situs inversus totalis: With video. 61
32875706 2021
3
Robotic-assisted surgery for rectal cancer with situs inversus totalis: A case report. 61
33797194 2021
4
Anesthetic management of a patient with situs inversus totalis undergoing coronary artery bypass grafting surgery: a case report. 61
33782777 2021
5
Left-sided appendicitis due to situs inversus totalis. 61
33768941 2021
6
Double rarity: malignant masquerade biliary stricture in a situs inversus totalis patient. 61
33743673 2021
7
Successful detection of covert paroxysmal atrial fibrillation due to insertable cardiac monitor in embolic stroke of undetermined source in a patient with situs inversus totalis. 61
33768885 2021
8
Laparoscopic Distal Gastrectomy for Synchronous Gastric Cancer and Gastrointestinal Stromal Tumor With Situs Inversus Totalis. 61
33622883 2021
9
Hydrops fetalis in PKD1L1-related heterotaxy: Report of two foetuses and expanding the phenotypic and molecular spectrum. 61
33655537 2021
10
Pure Laparoscopic Anatomic Right Hemihepatectomy for Hepatocellular Carcinoma with Situs Inversus Totalis Using Indocyanine Green Fluorescence Staining (with Video). 61
33615392 2021
11
ASO Author Reflections: A New Minimally Invasive Procedure for Hepatocellular Carcinoma with Situs Inversus Totalis. 61
33620618 2021
12
Respiratory Distress in the Newborn with Primary Ciliary Dyskinesia. 61
33670529 2021
13
Situs Inversus Totalis in the Neonatal Setting. 61
33654643 2021
14
Successful Catheter Ablation for Multiple Atrial Arrhythmias in a Patient with Situs Inversus Totalis. 61
33028769 2021
15
A Huge Ovarian Mucinous Cystadenoma in a 15-Year-Old Girl with Situs Inversus Totalis: Report of a Rare Case. 61
32688052 2021
16
Successful removal of multiple bile duct stones using a papillary large balloon dilation in a very elderly woman with situs inversus totalis. 61
32772241 2021
17
Upgrading from a Dual-chamber Pacemaker to a Cardiac Resynchronization Therapy Defibrillator in Situs Inversus Totalis with Dextrocardia Following Mitral Valve Replacement and Tricuspid Annuloplasty Using a Left-sided Approach. 61
33520351 2021
18
Total minimally invasive McKeown esophagectomy in an esophageal cancer patient with situs inversus totalis: A case report. 61
33155374 2021
19
Nasopharyngeal carcinoma in a child with Kartagener`s syndrome. 61
33686839 2021
20
Routine pre-employment echocardiography assessment in young adults: cost and benefits. 61
33409841 2021
21
A 2-Year-Old Boy With Hypoxemia, Pulmonary Hypertension, and Digital Clubbing. 61
33422240 2021
22
Situs inversus totalis and prenatal diagnosis of a primary ciliary dyskinesia. 61
32447765 2021
23
Performing Endoscopic Retrograde Cholagiopancreatpgraphy and Endoscopic Ultrasound for Management of Malignant Bile Duct Obstruction in a Patient With a Situs Inversus Totalis. 61
33324708 2020
24
Transverse colon cancer with obstruction in a patient with situs inversus totalis: A case report and review of literature. 61
32994114 2020
25
Catheter ablation of the atrioventricular node slow pathway sans fluoroscopy in a patient with situs inversus totalis. 61
33365251 2020
26
Operative Challenges with Minimally Invasive McKeown Esophagostomy with Two-Field Lymphadenectomy in a Case of Situs Inversus Totalis with Carcinoma Esophagus: A Case Report with Review of the Literature. 61
33299283 2020
27
Laparoendoscopic rendezvous procedure in a patient with situs inversus totalis: A case report and review of the literature. 61
33363786 2020
28
Minimally invasive dual-valve repair in situs inversus totalis: strategy for tricuspid valve. 61
33375817 2020
29
Assessment of Myocardial Viability Using Nuclear Medicine Imaging in Dextrocardia. 61
32887761 2020
30
Vallecular cyst: a dangerous cause of failure to thrive in infants. 61
33334753 2020
31
CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module. 61
33139725 2020
32
Unusual Coexistence In Situs Inversus Totalis; Right Arcus Aorta, Variant Left Azygos Lobe, and Aberrant Left Subclavian Artery. 61
32340770 2020
33
Robotic right colectomy for cancer with intracorporeal hand-sewn anastomosis in a patient with situs inversus totalis - a video vignette. 61
32495482 2020
34
Left atrial appendage closure in a patient with situs inversus totalis and interrupted inferior vena cava - A transhepatic approach. 61
33204625 2020
35
Video-assisted minimally invasive aortic valve replacement through left anterior mini-thoracotomy in a patient with situs inversus totalis. 61
32584985 2020
36
Robotic cholecystectomy in situs inversus totalis. 61
32386727 2020
37
Minimally invasive esophagectomy with intrathoracic anastomosis in a situs inversus totalis patient. 61
33274044 2020
38
Half-turned truncal switch operation after single ventricle palliation in a patient with borderline left heart hypoplasia. 61
33036641 2020
39
An ST-Elevation Myocardial Infarction In Situs Inversus Totalis (DEXTROCARDIA). 61
32713619 2020
40
Successful endoscopic retrograde cholangiopancreatography and bilateral stenting in a patient with situs inversus totalis. 61
33067158 2020
41
Atrial fibrillation and atrial flutter ablation using mirror image in a patient with dextrocardia with situs inversus. 61
33001046 2020
42
Acute Type A Aortic Dissection in a Patient with Situs Inversus Totalis. 61
32919440 2020
43
Successful biliary cannulation using a novel rotatable sphincterotome in a patient with situs inversus totalis. 61
32131093 2020
44
Successful endovascular repair of aortic rupture caused by axillary intra-aortic balloon insertion for a Jehovah's Witness patient with situs inversus anomaly. 61
32652620 2020
45
Laparoscopic Cholecystectomy in a Patient with Situs Inversus Totalis: Port Placement and Dissection Techniques. 61
32886654 2020
46
Ex vivo cardiovascular magnetic resonance diffusion weighted imaging in congenital heart disease, an insight into the microstructures of tetralogy of Fallot, biventricular and univentricular systemic right ventricle. 61
32951605 2020
47
Two types of lung cancer with situs inversus totalis: a case report and review of the literature. 61
33106071 2020
48
Laparoscopy-assisted resection of colorectal cancer with situs inversus totalis: A case report and literature review. 61
32994862 2020
49
Endoscopic submucosal dissection of early gastric cancer in a patient with situs inversus totalis. 61
32821864 2020
50
Deceased donor liver transplantation in an adult recipient with situs inversus totalis: A case report of 10-year clinical sequences following primary and repeat transplantation. 61
32843599 2020
Sources

Variations for Dextrocardia with Situs Inversus

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ClinVar genetic disease variations for Dextrocardia with Situs Inversus:

6 (show all 37)
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 CCDC103 NM_213607.3(CCDC103):c.558_559AG[7] (p.Ser190fs) Microsatellite Pathogenic 455029 rs746242380 GRCh37: 17:42980013-42980014
GRCh38: 17:44902645-44902646
2 PKD1L1 NM_138295.4(PKD1L1):c.6473+2_6473+3del Deletion Pathogenic 235796 rs528302390 GRCh37: 7:47870812-47870813
GRCh38: 7:47831214-47831215
3 PKD1L1 NM_138295.4(PKD1L1):c.5072G>C (p.Cys1691Ser) SNV Likely pathogenic 235198 rs886037834 GRCh37: 7:47886558-47886558
GRCh38: 7:47846960-47846960
4 BRWD1 NM_033656.4(BRWD1):c.5573A>T (p.Gln1858Leu) SNV Likely pathogenic 982437 GRCh37: 21:40570769-40570769
GRCh38: 21:39198843-39198843
5 MNS1 NM_018365.4(MNS1):c.407_410del (p.Glu136fs) Microsatellite Likely pathogenic 635005 rs1596264554 GRCh37: 15:56739085-56739088
GRCh38: 15:56446887-56446890
6 CFAP52 NM_145054.5(CFAP52):c.439G>A (p.Ala147Thr) SNV Uncertain significance 962973 GRCh37: 17:9497541-9497541
GRCh38: 17:9594224-9594224
7 CFAP52 NM_145054.5(CFAP52):c.1601G>C (p.Gly534Ala) SNV Uncertain significance 1054061 GRCh37: 17:9545066-9545066
GRCh38: 17:9641749-9641749
8 BRWD1 NM_033656.4(BRWD1):c.166G>A (p.Gly56Ser) SNV Uncertain significance 982435 GRCh37: 21:40684799-40684799
GRCh38: 21:39312873-39312873
9 BRWD1 NM_033656.4(BRWD1):c.523C>T (p.His175Tyr) SNV Uncertain significance 982436 GRCh37: 21:40667755-40667755
GRCh38: 21:39295829-39295829
10 BRWD1 NM_033656.4(BRWD1):c.1016T>C (p.Leu339Ser) SNV Uncertain significance 982514 GRCh37: 21:40649265-40649265
GRCh38: 21:39277339-39277339
11 CFAP52 NM_145054.5(CFAP52):c.482C>A (p.Ala161Asp) SNV Uncertain significance 841952 GRCh37: 17:9497584-9497584
GRCh38: 17:9594267-9594267
12 CFAP52 NM_145054.5(CFAP52):c.509G>A (p.Arg170Gln) SNV Uncertain significance 969026 GRCh37: 17:9497611-9497611
GRCh38: 17:9594294-9594294
13 CFAP52 NM_145054.5(CFAP52):c.1780C>T (p.Arg594Cys) SNV Uncertain significance 841069 GRCh37: 17:9546432-9546432
GRCh38: 17:9643115-9643115
14 CFAP52 NM_145054.5(CFAP52):c.734C>T (p.Ala245Val) SNV Uncertain significance 1001316 GRCh37: 17:9503481-9503481
GRCh38: 17:9600164-9600164
15 CFAP52 NM_145054.5(CFAP52):c.121T>C (p.Tyr41His) SNV Uncertain significance 942263 GRCh37: 17:9489140-9489140
GRCh38: 17:9585823-9585823
16 CFAP52 NM_145054.5(CFAP52):c.969A>T (p.Lys323Asn) SNV Uncertain significance 861945 GRCh37: 17:9515740-9515740
GRCh38: 17:9612423-9612423
17 CFAP52 NM_145054.5(CFAP52):c.1106G>A (p.Arg369Gln) SNV Uncertain significance 1038824 GRCh37: 17:9532069-9532069
GRCh38: 17:9628752-9628752
18 CFAP52 NM_145054.5(CFAP52):c.1752G>A (p.Val584=) SNV Uncertain significance 544337 rs1555545305 GRCh37: 17:9546404-9546404
GRCh38: 17:9643087-9643087
19 CFAP52 NM_145054.5(CFAP52):c.199G>A (p.Val67Ile) SNV Uncertain significance 544338 rs201479202 GRCh37: 17:9489218-9489218
GRCh38: 17:9585901-9585901
20 CFAP52 NM_145054.5(CFAP52):c.1442C>G (p.Thr481Ser) SNV Uncertain significance 565466 rs142289033 GRCh37: 17:9538843-9538843
GRCh38: 17:9635526-9635526
21 CFAP52 NM_145054.5(CFAP52):c.1492A>G (p.Met498Val) SNV Uncertain significance 573466 rs765338836 GRCh37: 17:9541945-9541945
GRCh38: 17:9638628-9638628
22 CFAP52 NM_145054.5(CFAP52):c.1625G>A (p.Gly542Asp) SNV Uncertain significance 574037 rs552119987 GRCh37: 17:9545090-9545090
GRCh38: 17:9641773-9641773
23 CFAP52 NM_145054.5(CFAP52):c.1404G>T (p.Arg468Ser) SNV Uncertain significance 581962 rs775063335 GRCh37: 17:9538805-9538805
GRCh38: 17:9635488-9635488
24 CFAP52 NM_145054.5(CFAP52):c.1430T>C (p.Val477Ala) SNV Uncertain significance 582339 rs77840450 GRCh37: 17:9538831-9538831
GRCh38: 17:9635514-9635514
25 CFAP52 NM_145054.5(CFAP52):c.189delinsAGCA (p.His63delinsGlnAla) Indel Uncertain significance 641856 rs1597763121 GRCh37: 17:9489208-9489208
GRCh38: 17:9585891-9585891
26 CFAP52 NM_145054.5(CFAP52):c.771G>T (p.Arg257Ser) SNV Uncertain significance 645178 rs1389914976 GRCh37: 17:9511453-9511453
GRCh38: 17:9608136-9608136
27 CFAP52 NM_145054.5(CFAP52):c.458C>T (p.Ala153Val) SNV Likely benign 707153 rs77839011 GRCh37: 17:9497560-9497560
GRCh38: 17:9594243-9594243
28 CFAP52 NM_145054.5(CFAP52):c.788G>A (p.Gly263Asp) SNV Likely benign 707233 rs139646620 GRCh37: 17:9511470-9511470
GRCh38: 17:9608153-9608153
29 CFAP52 NM_145054.5(CFAP52):c.1772C>T (p.Thr591Ile) SNV Likely benign 707582 rs112783393 GRCh37: 17:9546424-9546424
GRCh38: 17:9643107-9643107
30 CFAP52 NM_145054.5(CFAP52):c.1613G>C (p.Arg538Thr) SNV Likely benign 791562 rs140641061 GRCh37: 17:9545078-9545078
GRCh38: 17:9641761-9641761
31 CFAP52 NM_145054.5(CFAP52):c.873C>T (p.Gly291=) SNV Likely benign 798153 rs762482958 GRCh37: 17:9515644-9515644
GRCh38: 17:9612327-9612327
32 CFAP52 NM_145054.5(CFAP52):c.213C>T (p.Ala71=) SNV Benign 772897 rs143579503 GRCh37: 17:9489232-9489232
GRCh38: 17:9585915-9585915
33 CFAP52 NM_145054.5(CFAP52):c.1369C>T (p.Leu457=) SNV Benign 707357 rs140517505 GRCh37: 17:9538770-9538770
GRCh38: 17:9635453-9635453
34 CFAP52 NM_145054.5(CFAP52):c.1065T>C (p.Asp355=) SNV Benign 707484 rs57960962 GRCh37: 17:9532028-9532028
GRCh38: 17:9628711-9628711
35 CFAP52 NM_145054.5(CFAP52):c.1392G>T (p.Val464=) SNV Benign 707485 rs73975761 GRCh37: 17:9538793-9538793
GRCh38: 17:9635476-9635476
36 CFAP52 NM_145054.5(CFAP52):c.1692A>C (p.Gly564=) SNV Benign 707486 rs36018005 GRCh37: 17:9546344-9546344
GRCh38: 17:9643027-9643027
37 CFAP52 NM_145054.5(CFAP52):c.1026-3C>T SNV Benign 707576 rs75671790 GRCh37: 17:9531986-9531986
GRCh38: 17:9628669-9628669
Sources

Expression for Dextrocardia with Situs Inversus

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Search GEO for disease gene expression data for Dextrocardia with Situs Inversus.
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Pathways for Dextrocardia with Situs Inversus

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GO Terms for Dextrocardia with Situs Inversus

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Cellular components related to Dextrocardia with Situs Inversus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell projection GO:0042995 9.63 PKD1L1 DNAH9 CFAP53 CFAP52 CCDC103 ANKS3
2 axoneme GO:0005930 9.5 MNS1 DNAH9 CCDC103
3 outer dynein arm GO:0036157 9.26 DNAH9 CCDC103
4 motile cilium GO:0031514 9.26 MNS1 DNAH9 CFAP52 CCDC103
5 cilium GO:0005929 9.1 PKD1L1 DNAH9 CFAP53 CFAP52 CCDC103 ANKS3

Biological processes related to Dextrocardia with Situs Inversus according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 hematopoietic progenitor cell differentiation GO:0002244 9.52 MMP21 CITED2
2 vasculature development GO:0001944 9.51 NODAL CITED2
3 heart looping GO:0001947 9.5 NODAL CITED2 CCDC103
4 embryonic placenta development GO:0001892 9.49 NODAL CITED2
5 positive regulation of cell-cell adhesion GO:0022409 9.48 NODAL CITED2
6 trophectodermal cell differentiation GO:0001829 9.46 NODAL CITED2
7 epithelial cilium movement involved in determination of left/right asymmetry GO:0060287 9.43 CFAP53 CCDC103
8 cilium movement GO:0003341 9.43 DNAH9 CFAP53 CCDC103
9 determination of heart left/right asymmetry GO:0061371 9.4 MMP21 CITED2
10 embryonic process involved in female pregnancy GO:0060136 9.37 NODAL CITED2
11 nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry GO:1900164 9.16 NODAL CITED2
12 left/right axis specification GO:0070986 9.13 PKD1L1 MNS1 CITED2
13 determination of left/right symmetry GO:0007368 9.02 NODAL MMP21 CITED2 CFAP53 CCDC103
Sources

Sources for Dextrocardia with Situs Inversus

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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