Diabetes Insipidus disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: DBT005 MIFTS: 54	Diabetes Insipidus Categories: Endocrine diseases, Nephrological diseases, Rare diseases, Neuronal diseases
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Aliases & Classifications for Diabetes Insipidus

MalaCards integrated aliases for Diabetes Insipidus:

Name: Diabetes Insipidus ¹² ⁷⁶ ²⁹ ⁶ ⁴³ ⁴⁴ ¹⁵ ⁷³

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Endocrine diseases Nephrological diseases Neuronal diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Endocrine, nutritional and metabolic diseases

Disorders of other endocrine glands

Hypofunction and other disorders of pituitary gland

Diabetes insipidus

External Ids:

Disease Ontology ¹² DOID:9409

ICD10 ³³ E23.2

ICD9CM ³⁵ 253.5

MeSH ⁴⁴ D003919

NCIt ⁵⁰ C43263

SNOMED-CT ⁶⁸ 15771004 190484000

UMLS ⁷³ C0011848

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Summaries for Diabetes Insipidus

MedlinePlus : ⁴³ Diabetes insipidus (DI) causes frequent urination. You become extremely thirsty, so you drink. Then you urinate. This cycle can keep you from sleeping or even make you wet the bed. Your body produces lots of urine that is almost all water. DI is different from diabetes mellitus (DM), which involves insulin problems and high blood sugar. The symptoms can be similar. However, DI is related to how your kidneys handle fluids. It's much less common than DM. Urine and blood tests can show which one you have. Usually, DI is caused by a problem with your pituitary gland or your kidneys. Treatment depends on the cause of the problem. Medicines can often help. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Diabetes Insipidus is related to diabetes insipidus, nephrogenic, x-linked and wolfram syndrome 1. An important gene associated with Diabetes Insipidus is AVP (Arginine Vasopressin), and among its related pathways/superpathways are Neuroscience and Glucose / Energy Metabolism. The drugs Furosemide and Hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and pituitary, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : ⁷⁶ Diabetes insipidus (DI) is a condition characterized by large amounts of dilute urine and increased... more...

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Related Diseases for Diabetes Insipidus

Diseases in the Diabetes Insipidus family:

Hereditary Central Diabetes Insipidus

Acquired Central Diabetes Insipidus

Diseases related to Diabetes Insipidus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 370)

#	Related Disease	Score	Top Affiliating Genes
1	diabetes insipidus, nephrogenic, x-linked	35.2	AQP2 AVPR2
2	wolfram syndrome 1	34.0	AVP WFS1
3	wolfram syndrome	33.7	AVP CISD2 WFS1
4	diabetes insipidus, nephrogenic, autosomal	33.4	AQP2 ARHGAP4 AVP AVPR2 CLCNKA SLC12A1
5	wolfram syndrome 2	32.6	CISD2 WFS1
6	diabetes insipidus, neurohypophyseal	32.1	AQP2 AVP AVPR2 POMC PRL WFS1
7	nephrogenic syndrome of inappropriate antidiuresis	30.7	AVP AVPR2
8	burns	30.1	CRH INS
9	syndrome of inappropriate antidiuretic hormone	29.9	AQP2 AVP AVPR2 POMC
10	hypoaldosteronism	29.7	POMC REN
11	hypoadrenalism	29.7	CRH POMC
12	bartter disease	29.5	CLCNKA REN SLC12A1
13	empty sella syndrome	29.4	POMC PRL
14	pituitary infarct	29.1	POMC PRL
15	adenohypophysitis	29.0	POMC PRL
16	conn's syndrome	29.0	CRH POMC REN
17	pituitary apoplexy	28.9	INS POMC PRL
18	amenorrhea	28.7	CRH POMC PRL
19	hypokalemia	28.6	AQP2 POMC REN SLC12A1
20	hypopituitarism	28.4	CRH INS POMC PRL
21	acromegaly	28.4	INS POMC PRL
22	anorexia nervosa	28.1	CRH POMC PRL
23	chromophobe adenoma	28.0	AVP INS POMC PRL
24	sheehan syndrome	27.6	CRH INS POMC PRL
25	diabetes insipidus, nephrogenic, with mental retardation and intracerebral calcification	12.3
26	hereditary central diabetes insipidus	12.3
27	acquired central diabetes insipidus	12.3
28	gestational diabetes insipidus	12.3
29	dipsogenic diabetes insipidus	12.2
30	hypopituitarism, congenital, with central diabetes insipidus	12.0
31	x-linked intellectual disability-limb spasticity-retinal dystrophy-diabetes insipidus syndrome	12.0
32	langerhans cell histiocytosis	11.4
33	wolfram syndrome, mitochondrial form	11.0
34	hyperostosis frontalis interna	11.0
35	polyhydramnios, megalencephaly, and symptomatic epilepsy	11.0
36	wolfram-like syndrome, autosomal dominant	11.0
37	culler-jones syndrome	11.0
38	hashimoto-pritzker syndrome	11.0
39	bronchus cancer	10.8	AVP AVPR2
40	seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance	10.7	AQP2 AVP
41	peripheral vertigo	10.6	AQP2 AVP
42	benign essential hypertension	10.6	AVP REN
43	secondary adrenal insufficiency	10.5	AVP INS
44	vestibular disease	10.5	AQP2 AVP
45	central nervous system germinoma	10.4	AVP POMC
46	tuberculous epididymitis	10.4	AVP POMC
47	central nervous system germ cell tumor	10.4	AVP POMC
48	tuberculous empyema	10.4	AVPR2 POMC
49	histiocytosis	10.4
50	diabetes mellitus	10.3

Comorbidity relations with Diabetes Insipidus via Phenotypic Disease Network (PDN):

Acute Cystitis	Diabetes Insipidus, Nephrogenic, Autosomal
Hypothyroidism	Pituitary Hormone Deficiency, Combined, 2

Graphical network of the top 20 diseases related to Diabetes Insipidus:

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Symptoms & Phenotypes for Diabetes Insipidus

MGI Mouse Phenotypes related to Diabetes Insipidus:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	10.11	AQP2 POMC AVP PRL AVPR2 REN
2	homeostasis/metabolism	MP:0005376	10	INS AQP2 POMC AVP PRL AVPR2
3	growth/size/body region	MP:0005378	9.97	INS AQP2 POMC AVPR2 REN CISD2
4	integument	MP:0010771	9.81	INS AQP2 POMC PRL AVPR2 CISD2
5	mortality/aging	MP:0010768	9.61	INS AQP2 AVP POMC AVPR2 REN
6	renal/urinary system	MP:0005367	9.28	POMC AVP AVPR2 REN CISD2 SLC12A1

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Drugs & Therapeutics for Diabetes Insipidus

Drugs for Diabetes Insipidus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 358)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Furosemide

Approved, Vet_approved

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

54-31-9

3440

Hydrocortisone

Approved, Vet_approved

Phase 4,Phase 2,Phase 3

50-23-7

5754

Sevoflurane

Approved, Vet_approved

Phase 4,Phase 1,Not Applicable

28523-86-6

5206

Norepinephrine

Approved

Phase 4,Phase 3,Phase 2,Not Applicable

51-41-2

439260

Propofol

Approved, Investigational, Vet_approved

Phase 4,Phase 1,Not Applicable

2078-54-8

4943

Conivaptan

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

210101-16-9

151171

Tolvaptan

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

150683-30-0

216237

Epinephrine

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

51-43-4

5816

Racepinephrine

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

329-65-7

838

Ephedrine

Approved

Phase 4,Phase 2,Not Applicable

299-42-3

9294

Pseudoephedrine

Approved

Phase 4,Phase 2,Not Applicable

90-82-4

7028

Phenylephrine

Approved

Phase 4,Phase 2,Not Applicable

59-42-7

6041

Prednisolone

Approved, Vet_approved

Phase 4,Phase 3,Phase 2

50-24-8

5755

Oxymetazoline

Approved, Investigational

Phase 4,Phase 2,Not Applicable

1491-59-4

4636

Benzocaine

Approved, Investigational

Phase 4,Phase 2,Not Applicable

1994-09-7, 94-09-7

2337

Misoprostol

Approved

Phase 4

59122-46-2

5282381

Chlorothiazide

Approved, Vet_approved

Phase 4

58-94-6

2720

Methylprednisolone

Approved, Vet_approved

Phase 4,Phase 3,Phase 2

83-43-2

6741

Dexmedetomidine

Approved, Vet_approved

Phase 4

113775-47-6

68602 5311068

Metolazone

Approved

Phase 4,Phase 1

17560-51-9

4170

tannic acid

Approved, Nutraceutical

Phase 4,Phase 2,Not Applicable

Butyric Acid

Experimental, Investigational

Phase 4,Phase 3

107-92-6

264

Synephrine

Experimental

Phase 4

1994-07-5, 94-07-5

7172

Analgesics

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

diuretics

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Respiratory System Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Central Nervous System Depressants

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Adrenergic Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Adrenergic Agonists

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Adrenergic alpha-Agonists

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Adrenergic beta-Agonists

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Mydriatics

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Natriuretic Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Coagulants

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Sodium Potassium Chloride Symporter Inhibitors

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Cortisol succinate

Phase 4,Phase 2,Phase 3

Neurotransmitter Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Hemostatics

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Analgesics, Non-Narcotic

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Anesthetics

Phase 4,Phase 1,Not Applicable

Deamino Arginine Vasopressin

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Hormone Antagonists

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Anesthetics, General

Phase 4,Phase 1,Not Applicable

Anesthetics, Inhalation

Phase 4,Phase 1,Not Applicable

Anesthetics, Intravenous

Phase 4,Phase 1,Not Applicable

Hormones

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Oxytocics

Phase 4,Phase 2,Phase 1,Not Applicable,Early Phase 1

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Vasoconstrictor Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Anti-Asthmatic Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 437)

#	Name	Status	NCT ID	Phase	Drugs
1	Pharmacokinetics and Pharmacodynamics of Desmopressin Oral Lyophilisate Formulation in the Paediatric Population	Unknown status	NCT02584231	Phase 4	desmopressin
2	Desmopressin for Improving Nocturnal Enuresis in Patients After Radical Cystectomy With Bladder Reconstruction	Unknown status	NCT01582542	Phase 4	Desmopressin
3	Desmopressin Melt Therapy in Nocturnal Polyuria Patients: Pharmacodynamic Study	Unknown status	NCT01439997	Phase 4	Desmopressin
4	Desmopressin for Bleeding Related to Low Body Temperature	Unknown status	NCT00902057	Phase 4	desmopressin;desmopressin;desmopressin;placebo
5	Tolvaptan for Hyponatremia in Cirrhotic Patients With Ascites	Unknown status	NCT01716611	Phase 4	Tolvaptan;placebo
6	Effect of Samsca on Control of Hyponatremia and Extracellular Fluid in Cirrhotic Patients With Ascites	Unknown status	NCT01552590	Phase 4	Tolvaptan;Placebo
7	Pilot Study of Using Copeptin to Predict Response to Tolvaptan	Completed	NCT01346072	Phase 4	tolvaptan
8	1-deamino 8-d-arginine Vasopressin (DDAVP) in Percutaneous Ultrasound-guided Renal Biopsy	Completed	NCT00748072	Phase 4	DDAVP;saline solution
9	Vasopressin and Epinephrine Versus Epinephrine Alone in Cardiac Arrest	Completed	NCT00127907	Phase 4	epinephrine (1 mg/1 mL);arginine-vasopressin (40 UI/2 mL)
10	Desmopressin in Cardiac Surgery	Completed	NCT00337766	Phase 4	Desmopressin (DDAVP);Placebo
11	Desmopressin in the Treatment of Mixed Nocturia With Nocturnal Polyuria and Low Nocturnal Bladder Capacity	Completed	NCT00902655	Phase 4	Desmopressin
12	Study of the Use of Misoprostol to Decrease Bleeding During a Myomectomy	Completed	NCT01700478	Phase 4	Misoprostol + vasopressin;Vasopressin
13	Desmopressin Melt: Impact on Sleep and Daytime Functioning	Completed	NCT01645475	Phase 4	Desmopressin lyophilisate (Melt)
14	Effects of Tolvaptan in Healthy Adults	Completed	NCT01973140	Phase 4	Tolvaptan;Hypertonic saline infusion
15	Effects on Exercise Hemodynamics of Vasopressin Blockade by Conivaptan Infusion in Heart Failure Patients	Completed	NCT01752543	Phase 4	Conivaptan;Placebo (Dextrose)
16	A New Check-list Method for Nocturnal Enuresis	Completed	NCT03510975	Phase 4	desmopressin melt form 120 μg
17	Effects of Desmopressin on Blood Loss and the Quality of the Surgical Field During Endoscopic Sinus Surgery	Completed	NCT02125188	Phase 4	Desmopressin;saline
18	Severe Aortic Stenosis and Acquired Von Willebrand´s Disease: The Impact of Desmopressin in Valve-Replacement Surgery	Completed	NCT01994330	Phase 4	desmopressin
19	Desmopressin Melt Therapy in Patients With Nocturnal Polyuria: a Pharmacokinetic/Dynamic Study	Completed	NCT01435083	Phase 4	Desmopressin
20	Influence of Food-intake on Desmopressin Oral Tablets and MELT-formulation	Completed	NCT01036841	Phase 4	desmopressin tablet;desmopressin MELT formulation
21	A Study of Oral Desmopressin in Previously Untreated Children Aged 5 to 15 Years With Primary Nocturnal Enuresis	Completed	NCT00245479	Phase 4	Primary nocturnal enuresis
22	A 6-week Open Label Cross-over Study With 2 Different Daily Doses of Minirin® Oral Lyophilisate in Children and Adolescents With Primary Nocturnal Enuresis (PNE)	Completed	NCT00209261	Phase 4	MINIRIN Oral Lyophilisate;Minirin tablet
23	Vasopressin Administration During Laparoscopic Myomectomy: a Randomized Controlled Trial	Completed	NCT01393704	Phase 4	Vasopressin
24	Comparison of the Effects of Cervical Vasopressin Versus no Premedication on Blood Loss During Vaginal Hysterectomy: A Randomized, Placebo Controlled Trial	Completed	NCT00799292	Phase 4	Vasopressin
25	Effects of Vasopressors on Immune Response	Completed	NCT02675868	Phase 4	Norepinephrine;Phenylephrine;Vasopressins;Placebo
26	Effect of Tolvaptan on Mid- to Long-term Prognosis of Heart Failure Patients	Completed	NCT01439009	Phase 4	Tolvaptan;Placebo of tolvaptan
27	Tolvaptan for Ascites in Cirrhotic Patients	Completed	NCT01292304	Phase 4	Tolvaptan
28	Tolvaptan in Hyponatremic Cancer Patients	Completed	NCT01199198	Phase 4	Tolvaptan;Placebo
29	A Study of Multiple Dosing Regimens of IV Conivaptan in Subjects With Euvolemic or Hypervolemic Hyponatremia	Completed	NCT00435591	Phase 4	Conivaptan;placebo
30	Tolvaptan/Ultrafiltration in the Treatment of Acute Heart Failure	Completed	NCT01863511	Phase 4	loop diuretic;tolvaptan
31	The Safety and Efficacy of Tolvaptan for Patients With Tricuspid Regurgitation and Right Heart Failure After Left Heart Valves Replacement	Completed	NCT02644616	Phase 4	tolvaptan+torasemide;placebo+torasemide
32	Metabolism of Isotonic Versus Hypotonic Maintenance Solutions in Fasting Healthy Adults	Completed	NCT02822898	Phase 4	NaCl 0.9% in Glucose 5% with 40mEq Potassium;Glucion 5%
33	Tolvaptan For Worsening Outpatient Heart Failure: Role of Copeptin In Identifying Responders	Recruiting	NCT02476409	Phase 4	tolvaptan
34	The Effect of MIDazolam PREmedication on COPeptine Concentration in Blood	Recruiting	NCT03474939	Phase 4	Midazolam Oral Tablet
35	The Effect of Selecting Treatment With Desmopressin or Alarm to Children With Enuresis Based on Home Recordings.	Recruiting	NCT03389412	Phase 4	Desmopressin
36	The Effect of Propofol or Sevoflurane on Renal Function	Recruiting	NCT03336801	Phase 4	Propofol;Sevoflurane
37	Exercise Versus DDAVP in Patients With Mild Hemophilia A	Recruiting	NCT03379974	Phase 4	DDAVP Inhalant Product
38	DDAVP vs. Exercise in Patients With Mild Hemophilia A	Recruiting	NCT03136003	Phase 4	DDAVP
39	Effect of Dexmedetomidine on Plasmatic Cortisol Response in Transsphenoidal Surgery	Recruiting	NCT02549768	Phase 4	Dexmedetomidine;Sodium Chloride 0.9%
40	Regional Tolvaptan Registry	Recruiting	NCT02666651	Phase 4	Tolvaptan
41	Tolvaptan for Advanced or Refractory Heart Failure	Recruiting	NCT02959411	Phase 4	Tolvaptan;Standard of care diuretic therapy
42	Aquaresis Utility for Hyponatremic Acute Heart Failure Study	Recruiting	NCT02183792	Phase 4	Tolvaptan;Furosemide
43	Effect of Vasopressin, Steroid, and Epinephrine Treatment in Patients With Out-of-hospital Cardiac Arrest	Recruiting	NCT03317197	Phase 4	Control Group;Experimental Group 1;Experimental Group 2;Experimental Group 3
44	Vasoactive Drugs in Intensive Care Unit	Recruiting	NCT02118467	Phase 4	Norepinephrine;Epinephrine;Phenylephrine;Vasopressin
45	Effects of Prophylactic Desmopressin on Blood Coagulation Parameters in Heart Valve Surgery	Active, not recruiting	NCT03343418	Phase 4	Desmopressin;Placebo
46	Comparison of Oral or Intravenous Thiazides vs Tolvaptan in Diuretic Resistant Decompensated Heart Failure	Enrolling by invitation	NCT02606253	Phase 4	tolvaptan;Chlorothiazide;Metolazone
47	Tolvaptan to Reduce Length of Stay in Hospitalized Patients With Cirrhosis and Hyponatremia	Terminated	NCT01890694	Phase 4	Tolvaptan;Placebo
48	Desmopressin as Treatment for Postoperative Bleeding After Cardiac Surgery	Terminated	NCT00885924	Phase 4	Desmopressin;Placebo
49	Effect of Desmopressin on the Nocturnal Micturition Frequency in Patients With Parkinson Disease	Terminated	NCT00806468	Phase 4	Desmotabs
50	Outcome and Treatment Quality Study of Tolvaptan to Treat Hyponatremia in Patients With Heart Failure	Terminated	NCT02352285	Phase 4	Tolvaptan;Placebo

Search NIH Clinical Center for Diabetes Insipidus

Inferred drug relations via UMLS ⁷³ / NDF-RT ⁵¹ :

desmopressin

desmopressin acetate

vasopressin (usp)

vasopressin tannate (in oil)

Cochrane evidence based reviews: diabetes insipidus

Sources

Genetic Tests for Diabetes Insipidus

Genetic tests related to Diabetes Insipidus:

#	Genetic test	Affiliating Genes
1	Diabetes Insipidus ²⁹

Sources

Anatomical Context for Diabetes Insipidus

MalaCards organs/tissues related to Diabetes Insipidus:

⁴¹

Heart, Kidney, Pituitary, Brain, Liver, Testes, Lung

Sources

Publications for Diabetes Insipidus

Articles related to Diabetes Insipidus:

(show top 50) (show all 1345)

#	Title	Authors	Year
1	Hemorrhagic fever with renal syndrome accompanied by panhypopituitarism and central diabetes insipidus: a case report. ( 29508304 )	Ahn H.J....Kim C.M.	2018
2	Oxcarbazepine Therapy for Complete Central Diabetes Insipidus. ( 29594147 )	Abdallah B....Braden G.	2018
3	Delayed Occurrence of Diabetes Insipidus After Transsphenoidal Surgery with Radiologic Evaluation of the Pituitary Stalk on Magnetic Resonance Imaging. ( 29229338 )	Hayashi Y....Nakada M.	2018
4	Contiguous 22.1-kb deletion embracing AVPR2 and ARHGAP4 genes at novel breakpoints leads to nephrogenic diabetes insipidus in a Chinese pedigree. ( 29394883 )	Bai Y....Kong X.	2018
5	SOCIETY FOR ENDOCRINOLOGY CLINICAL GUIDANCE: Inpatient management of cranial diabetes insipidus. ( 29930026 )	Baldeweg S.E....Wass J.	2018
6	Novel and recurrent variants in AVPR2 in 19 families with X-linked congenital nephrogenic diabetes insipidus. ( 29594432 )	Joshi S....FA	2018
7	AKAPs-PKA disruptors increase AQP2 activity independently of vasopressin in a model of nephrogenic diabetes insipidus. ( 29650969 )	Ando F....Uchida S.	2018
8	Postoperative Diabetes Insipidus and Hyponatremia in Children after Transsphenoidal Surgery for Adrenocorticotropin Hormone and Growth Hormone Secreting Adenomas. ( 29395172 )	Saldarriaga C....Lodish M.	2018
9	Rapid differential diagnosis of diabetes insipidus in a 7-month-old infant: The copeptin approach. ( 29241593 )	Vergier J....Reynaud R.	2018
10	For Debate: Personalized Health Care: As Exemplified by Home Sodium Measurements in a Child with Central Diabetes Insipidus and Impaired Thirst Perception. ( 29806747 )	van der Linde A.A.A....de Grouw E.P.L.M.	2018
11	One too many diabetes: the combination of hyperglycaemic hyperosmolar state and central diabetes insipidus. ( 29675260 )	Burmazovic S....Cioccari L.	2018
12	Bartter Syndrome Type 1 Presenting as Nephrogenic Diabetes Insipidus. ( 29527380 )	Vergine G....Borsa N.	2018
13	From Mechanical to Chemical: A Case of Diabetes Insipidus Induced by Concussive Brain Injury. ( 29596786 )	Shahid M.H....Youngblood L.	2018
14	Diabetes Insipidus following Endoscopic Transsphenoidal Surgery for Pituitary Adenoma. ( 29868315 )	Ajlan A.M....Harsh G.R.	2018
15	Systemic lupus erythematosus with SjAPgren's syndrome and renal tubular acidosis presenting as nephrogenic diabetes insipidus. ( 29657217 )	Parrey A.H....Basher A.	2018
16	Nephrogenic diabetes insipidus in initial stage of acute lymphoblastic leukemia and relapse after haploidentical hematopoietic stem-cell transplantation: A case report. ( 29901649 )	Li D....Feng S.	2018
17	Functional characterization of AVPR2 mutants found in Turkish patients with nephrogenic diabetes insipidus. ( 29117938 )	Erdem B....Mergen H.	2018
18	Relation between change in treatment for central diabetes insipidus and body weight loss. ( 29424204 )	Ito A....Kawakami A.	2018
19	A rat model for pituitary stalk electric lesion-induced central diabetes insipidus: application of 3D printing and further outcome assessments. ( 29681579 )	Feng Z....Qi S.	2018
20	Chemical chaperone 4-phenylbutylate reduces mutant protein accumulation in the endoplasmic reticulum of arginine vasopressin neurons in a mouse model for familial neurohypophysial diabetes insipidus. ( 29886132 )	Tochiya M....Arima H.	2018
21	Diabetes insipidus is an unfavorable prognostic factor for response to glucocorticoids in patients with autoimmune hypophysitis. ( 29141992 )	Chiloiro S....De Marinis L.	2018
22	Tamoxifen attenuates development of lithium-induced nephrogenic diabetes insipidus in rats. ( 29357422 )	Tingskov S.J....kiA	2018
23	Anti-PD-L1 Treatment Induced Central Diabetes Insipidus. ( 29220526 )	Zhao C....Brownell I.	2018
24	Resolution of Diabetes Insipidus After Pyeloplasty: A Case Report and Review of the Literature. ( 29499256 )	Carpenter C.P....Giel D.W.	2018
25	Severe localised granulomatosis with polyangiitis (Wegener's granulomatosis) manifesting with extensive cranial nerve palsies and cranial diabetes insipidus: a case report and literature review. ( 29716529 )	Peters J.E....Jawad A.S.M.	2018
26	Brain Death in Children: Incidence, Donation Rates, and the Occurrence of Central Diabetes Insipidus. ( 29967895 )	Yener N....KAPksoy A.9.	2018
27	A novel mechanism of autophagy-associated cell death of vasopressin neurons in familial neurohypophysial diabetes insipidus. ( 29961215 )	Hagiwara D....Arima H.	2018
28	'If there were water we should stop and drink': neurofibromatosis presenting with diabetes insipidus. ( 29440241 )	Barry R....O' Toole O.	2018
29	Treatment of congenital nephrogenic diabetes insipidus in pregnancy. ( 29512817 )	Gala-BA8A8dziA8ska A....DarmochwaA8-Kolarz D.	2018
30	Cardiovascular autonomic dysfunction in patients with idiopathic diabetes insipidus. ( 29081004 )	Barbot M....Bilora F.	2018
31	Transient diabetes insipidus in a post-partum woman with pre-eclampsia associated with residual placental vasopressinase activity. ( 29850023 )	Rodrigo N....Hocking S.	2018
32	The clinical course and pathophysiological investigation of adolescent gestational diabetes insipidus: a case report. ( 29378555 )	Kondo T....Araki E.	2018
33	Overlap of Post-obstructive Diuresis and Unmasked Diabetes Insipidus in a Case of IgG4-related Retroperitoneal Fibrosis and Tuberoinfundibular Hypophysitis: A Case Report and Review of the Literature. ( 28049999 )	Sasaki Yatabe M....Watanabe T.	2017
34	Opioid-induced hyponatremia in a patient with central diabetes insipidus: independence from ADH. ( 28593907 )	Bhat N....Wilson T.	2017
35	Treatment regimens by pediatric nephrologists in children with congenital nephrogenic diabetes insipidus: A MWPNC studya8c. ( 29162216 )	D'Alessandri-Silva C....Mahan J.D.	2017
36	A case of gestational central diabetes insipidus with oligohydramnios. ( 28764595 )	Park J.W....Han S.Y.	2017
37	Diabetes insipidus after discontinuation of vasopressin infusion for septic shock. ( 28895166 )	Rana H....Dicpinigaitis P.V.	2017
38	A Case of Osteomyelitis of the toe caused by Coccidioidomycosis in a 17 year-old with Diabetes Insipidus. ( 28560172 )	Khalid A....Totten V.Y.	2017
39	Xanthomatous Hypophysitis Presenting with Diabetes Insipidus Completely Cured Through Transsphenoidal Surgery: Case Report and Literature Review. ( 28583458 )	Lin W....Xing B.	2017
40	Two Cases of Central Diabetes Insipidus in Refractory Antineutrophil Cytoplasmic Antibody-associated Vasculitis. ( 28943556 )	Ohashi K....Wada J.	2017
41	Delirium after thiazide diuretic suspension can unmask diabetes insipidus. ( 29265751 )	Gabriele S....Zamboni M.	2017
42	Diabetes Insipidus ( 29262153 )	Hui C....Radbel J.M.	2017
43	Diabetes insipidus and the use of desmopressin in hospitalised children. ( 28073809 )	Elder C.J....Dimitri P.J.	2017
44	Mice deficient for ERAD machinery component Sel1L develop central diabetes insipidus. ( 28920918 )	Bichet D.G....Lussier Y.	2017
45	The soluble (Pro) renin receptor does not influence lithium-induced diabetes insipidus but does provoke beiging of white adipose tissue in mice. ( 29138356 )	Yang K.T....David Symons J.	2017
46	Tuberculoma of the pituitary gland presenting as diabetes insipidus. ( 28681785 )	Reddy R.	2017
47	Diabetes insipidus and hypopituitarism in HIV: an unexpected cause. ( 28620498 )	Tavares Bello C....Vasconcelos C.	2017
48	Novel<i>de novo AVPR2</i>Variant in a Patient with Congenital Nephrogenic Diabetes Insipidus. ( 29177155 )	Joshi S....Christensen J.H.	2017
49	Hereditary Nephrogenic Diabetes Insipidus: Pathophysiology and Possible Treatment. An Update. ( 29125546 )	Milano S....Procino G.	2017
50	Pulmonary langerhans cell histiocytosis case with diabetes insipidus and tuberculosis. ( 28406136 )	Ugurlu E....Bir F.	2017

Sources

Genes for Diabetes Insipidus

Genes related to Diabetes Insipidus (0 elite genes):

(show all 13)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	AVP	Arginine Vasopressin	Protein Coding	81.18	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Gene name Summaries Pathways & Interactions Variants (show sections)
2	AVPR2	Arginine Vasopressin Receptor 2	Protein Coding	80.08	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Gene name Summaries Pathways & Interactions Variants (show sections)
3	AQP2	Aquaporin 2	Protein Coding	58.45	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
4	WFS1	Wolframin ER Transmembrane Glycoprotein	Protein Coding	44.75	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries (show sections)
5	ARHGAP4	Rho GTPase Activating Protein 4	Protein Coding	40.7	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Summaries Variants (show sections)
6	CLCNKA	Chloride Voltage-Gated Channel Ka	Protein Coding	30.44	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Functions (show sections)
7	POMC	Proopiomelanocortin	Protein Coding	24.21	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	CISD2	CDGSH Iron Sulfur Domain 2	Protein Coding	23.32	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders (show sections)
9	PRL	Prolactin	Protein Coding	23.01	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	REN	Renin	Protein Coding	22.94	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
11	CRH	Corticotropin Releasing Hormone	Protein Coding	22.24	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	INS	Insulin	Protein Coding	22.09	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
13	SLC12A1	Solute Carrier Family 12 Member 1	Protein Coding	21.72	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

Sources

Variations for Diabetes Insipidus

ClinVar genetic disease variations for Diabetes Insipidus:

⁶

#	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1	MATN4	NM_030590.3(MATN4): c.515G> C (p.Gly172Ala)	single nucleotide variant	Likely pathogenic	rs730882210	GRCh38	Chromosome 20, 45304356: 45304356
2	MATN4	NM_030590.3(MATN4): c.515G> C (p.Gly172Ala)	single nucleotide variant	Likely pathogenic	rs730882210	GRCh37	Chromosome 20, 43932996: 43932996

Sources

Expression for Diabetes Insipidus

Search GEO for disease gene expression data for Diabetes Insipidus.

Sources

Pathways for Diabetes Insipidus

Pathways related to Diabetes Insipidus according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Neuroscience ⁴	12.16	AVP POMC SLC12A1 WFS1
2	Glucose / Energy Metabolism ⁴	12.05	AQP2 CISD2 INS WFS1
3	Peptide hormone metabolism ⁶⁶ Show member pathways Glycoprotein hormones ⁶⁶ Insulin processing ⁶⁶ Metabolism of Angiotensinogen to Angiotensins ⁶⁶ Peptide hormone biosynthesis ⁶⁶ Synthesis, secretion, and deacylation of Ghrelin ⁶⁶	11.8	INS POMC REN
4	G alpha (s) signalling events ⁶⁶	11.09	AVP AVPR2 CRH POMC
5	Diuretics Pathway, Pharmacodynamics ⁶¹	10.87	CLCNKA SLC12A1
6	Vasopressin-regulated water reabsorption ³⁷	10.78	AQP2 AVP AVPR2
7	Glucocorticoid Pathway (HPA Axis), Pharmacodynamics ⁶¹	10	CRH POMC

Sources

GO Terms for Diabetes Insipidus

Cellular components related to Diabetes Insipidus according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.43	AVP CRH INS POMC PRL REN
2	endosome lumen	GO:0031904	8.62	INS PRL

Biological processes related to Diabetes Insipidus according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of signaling receptor activity	GO:0010469	9.76	AVP INS POMC PRL
2	positive regulation of gene expression	GO:0010628	9.67	AVP AVPR2 CRH INS
3	positive regulation of cell proliferation	GO:0008284	9.55	AVP AVPR2 CRH INS PRL
4	glucose homeostasis	GO:0042593	9.5	INS POMC WFS1
5	positive regulation of vasoconstriction	GO:0045907	9.48	AVP AVPR2
6	response to immobilization stress	GO:0035902	9.43	CRH REN
7	water transport	GO:0006833	9.4	AQP2 AVP
8	positive regulation of systemic arterial blood pressure	GO:0003084	9.26	AVP AVPR2
9	excretion	GO:0007588	9.13	AQP2 AVPR2 CLCNKA
10	renal water homeostasis	GO:0003091	8.92	AQP2 AVP AVPR2 WFS1

Molecular functions related to Diabetes Insipidus according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	signaling receptor binding	GO:0005102	9.56	AVP CRH POMC REN
2	insulin-like growth factor receptor binding	GO:0005159	9.16	INS REN
3	neuropeptide hormone activity	GO:0005184	9.13	AVP CRH POMC
4	hormone activity	GO:0005179	9.02	AVP CRH INS POMC PRL

Sources

Sources for Diabetes Insipidus

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia

Diabetes Insipidus

Aliases & Classifications for Diabetes Insipidus

MalaCards integrated aliases for Diabetes Insipidus:

Classifications:

External Ids:

Summaries for Diabetes Insipidus

Related Diseases for Diabetes Insipidus

Diseases in the Diabetes Insipidus family:

Diseases related to Diabetes Insipidus via text searches within MalaCards or GeneCards Suite gene sharing:

Comorbidity relations with Diabetes Insipidus via Phenotypic Disease Network (PDN):

Graphical network of the top 20 diseases related to Diabetes Insipidus:

Symptoms & Phenotypes for Diabetes Insipidus

MGI Mouse Phenotypes related to Diabetes Insipidus:

Drugs & Therapeutics for Diabetes Insipidus

Drugs for Diabetes Insipidus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 73 / NDF-RT 51 :

Cochrane evidence based reviews: diabetes insipidus

Genetic Tests for Diabetes Insipidus

Genetic tests related to Diabetes Insipidus:

Anatomical Context for Diabetes Insipidus

MalaCards organs/tissues related to Diabetes Insipidus:

Publications for Diabetes Insipidus

Articles related to Diabetes Insipidus:

Genes for Diabetes Insipidus

Genes related to Diabetes Insipidus (0 elite genes):

Variations for Diabetes Insipidus

ClinVar genetic disease variations for Diabetes Insipidus:

Expression for Diabetes Insipidus

Pathways for Diabetes Insipidus

Pathways related to Diabetes Insipidus according to GeneCards Suite gene sharing:

GO Terms for Diabetes Insipidus

Cellular components related to Diabetes Insipidus according to GeneCards Suite gene sharing:

Biological processes related to Diabetes Insipidus according to GeneCards Suite gene sharing:

Molecular functions related to Diabetes Insipidus according to GeneCards Suite gene sharing:

Sources for Diabetes Insipidus

Inferred drug relations via UMLS ⁷³ / NDF-RT ⁵¹ :