Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Our Publications Academic Licensing Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: DBT009
MIFTS: 64

Diabetes Mellitus

Categories: Endocrine diseases, Metabolic diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Diabetes Mellitus

About this section

MalaCards integrated aliases for Diabetes Mellitus:

Name: Diabetes Mellitus 38 12 76 29 55 6 44 15 73
Diabetes 43 3 40 73

Classifications:

MalaCards categories:
Global: Metabolic diseases
Anatomical: Endocrine diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:9351
ICD9CM 35 250
MeSH 44 D003920
NCIt 50 C2985
Sources

Summaries for Diabetes Mellitus

About this section
MedlinePlus : 43 Diabetes is a disease in which your blood glucose, or blood sugar, levels are too high. Glucose comes from the foods you eat. Insulin is a hormone that helps the glucose get into your cells to give them energy. With type 1 diabetes, your body does not make insulin. With type 2 diabetes, the more common type, your body does not make or use insulin well. Without enough insulin, the glucose stays in your blood. You can also have prediabetes. This means that your blood sugar is higher than normal but not high enough to be called diabetes. Having prediabetes puts you at a higher risk of getting type 2 diabetes. Over time, having too much glucose in your blood can cause serious problems. It can damage your eyes, kidneys, and nerves. Diabetes can also cause heart disease, stroke and even the need to remove a limb. Pregnant women can also get diabetes, called gestational diabetes. Blood tests can show if you have diabetes. One type of test, the A1C, can also check on how you are managing your diabetes. Exercise, weight control and sticking to your meal plan can help control your diabetes. You should also monitor your blood glucose level and take medicine if prescribed. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Diabetes Mellitus, also known as diabetes, is related to diabetes mellitus, permanent neonatal and neonatal diabetes mellitus, and has symptoms including angina pectoris, tremor and equilibration disorder. An important gene associated with Diabetes Mellitus is KCNJ11 (Potassium Voltage-Gated Channel Subfamily J Member 11), and among its related pathways/superpathways are Aldosterone synthesis and secretion and MicroRNAs in cancer. The drugs Linagliptin and Metformin have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and endothelial.

Disease Ontology : 12 A glucose metabolism disease characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both.

Novus Biologicals : 56 Diabetes is a disease in which the body does not produce or properly use insulin. There are four major types of diabetes: Type 1, Type 2, Gestational and Pre-Diabetes. Type 1 diabetes, previously known as juvenile diabetes, is an autoimmune disease resulting when one's own immune system destroys insulin-producing beta cells in the pancreas. This causes the pancreas to produce little or no insulin. In type 2 diabetes, the body either does not produce enough insulin or beta cells ignore insulin. Gestational diabetes refers to high glucose levels caused by pregnancy. Pre-diabetes is a condition in which blood glucose levels are high, but not high enough for the diagnosis of type 2 diabetes.

Wikipedia : 76 Diabetes mellitus (DM), commonly referred to as diabetes, is a group of metabolic disorders in which... more...

Sources

Related Diseases for Diabetes Mellitus

About this section

Diseases in the Diabetes Mellitus family:

Diabetes Mellitus, Congenital Autoimmune Type 1 Diabetes Mellitus 2
Type 1 Diabetes Mellitus 3 Type 1 Diabetes Mellitus 4
Type 1 Diabetes Mellitus 5 Type 1 Diabetes Mellitus 6
Type 1 Diabetes Mellitus 7 Type 1 Diabetes Mellitus 8
Type 1 Diabetes Mellitus 10 Type 1 Diabetes Mellitus 11
Type 1 Diabetes Mellitus 12 Type 1 Diabetes Mellitus 13
Type 1 Diabetes Mellitus 15 Type 1 Diabetes Mellitus 17
Type 1 Diabetes Mellitus 18

Diseases related to Diabetes Mellitus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1062)
# Related Disease Score Top Affiliating Genes
1 diabetes mellitus, permanent neonatal 36.6 ABCC8 INS KCNJ11 PDX1
2 neonatal diabetes mellitus 36.4 ABCC8 INS KCNJ11 PDX1
3 diabetes mellitus, transient neonatal, 1 36.4 ABCC8 INS KCNJ11
4 epiphyseal dysplasia, multiple, with early-onset diabetes mellitus 35.7 ABCC8 KCNJ11
5 maturity-onset diabetes of the young 35.6 ABCC8 INS KCNJ11 PDX1
6 diabetes mellitus, noninsulin-dependent 35.3 ABCC8 CDKN2B-AS1 INS KCNJ11 PDX1 PVT1
7 diabetes mellitus, insulin-dependent 34.8 INS MEG3 PDX1 PVT1
8 microvascular complications of diabetes 3 32.9 INS MALAT1 PVT1
9 hypoglycemia 32.6 ABCC8 INS KCNJ11
10 abdominal obesity-metabolic syndrome 1 32.6 INS MEG3
11 hyperglycemia 32.6 ABCC8 INS KCNJ11 MALAT1 PDX1
12 monogenic diabetes 32.5 ABCC8 INS KCNJ11 PDX1
13 pancreatic agenesis 32.5 ABCC8 INS KCNJ11 PDX1
14 insulinoma 32.3 ABCC8 INS MEN1 PDX1
15 acute insulin response 32.3 ABCC8 INS KCNJ11
16 hyperinsulinism 32.3 ABCC8 INS KCNJ11
17 hyperinsulinemic hypoglycemia 32.0 ABCC8 INS KCNJ11
18 factitious disorder 31.8 ABCC8 INS KCNJ11
19 glucose metabolism disease 31.6 ABCC8 INS KCNJ11
20 coronary artery anomaly 31.5 CDKN2B-AS1 INS MIR145 MIR155
21 hypertension, essential 31.0 CDKN2B-AS1 INS MEN1 MIR155
22 fanconi-bickel syndrome 31.0 ABCC8 INS
23 diffuse large b-cell lymphoma 29.8 MIR145 MIR155 MIR99A
24 kidney cancer 29.7 MALAT1 MEG3 PVT1
25 lymphoma, hodgkin, classic 29.7 MIR140 MIR155 PVT1
26 pancreatic ductal adenocarcinoma 29.3 MALAT1 MIR145 MIR155 MIR375 PVT1
27 thyroid cancer, nonmedullary, 1 28.9 MALAT1 MEG3 MIR155 PVT1
28 gallbladder cancer 28.6 CDKN2B-AS1 MALAT1 MEG3 TUG1
29 myeloma, multiple 28.5 MALAT1 MEG3 PVT1 TUG1
30 gastric cancer 28.1 CDKN2B-AS1 MALAT1 MEG3 MIR145 PVT1 TUG1
31 melanoma 28.1 CDKN2B-AS1 MALAT1 MEG3 MIR140 PVT1
32 bladder cancer 27.6 CDKN2B-AS1 MALAT1 MEG3 MIR145 MIR99A PVT1
33 pancreatic cancer 27.3 CDKN2B-AS1 MALAT1 MEG3 MEN1 MIR155 MIR375
34 prostate cancer 27.2 CDKN2B-AS1 MALAT1 MEG3 MIR145 MIR375 MIR99A
35 ovarian cancer 26.7 CDKN2B-AS1 MALAT1 MEG3 MIR134 MIR155 MIR99A
36 hepatocellular carcinoma 26.6 CDKN2B-AS1 MALAT1 MEG3 MIR132 MIR145 MIR155
37 colorectal cancer 26.5 CDKN2B-AS1 MALAT1 MEG3 MIR132 MIR140 MIR145
38 lung cancer 26.3 CDKN2B-AS1 MALAT1 MEG3 MIR140 MIR145 MIR155
39 diabetes mellitus, ketosis-prone 12.5
40 diabetes mellitus, insulin-dependent, 20 12.5
41 diabetes mellitus, insulin-dependent, 22 12.5
42 type 1 diabetes mellitus 10 12.4
43 diabetes mellitus, insulin-dependent, 10 12.4
44 pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities 12.4
45 diabetes mellitus, noninsulin-dependent, 1 12.4
46 diabetes mellitus, insulin-dependent, 19 12.4
47 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 12.4
48 diabetes mellitus, insulin-dependent, 21 12.4
49 diabetes mellitus, insulin-dependent, 23 12.4
50 diabetes mellitus, insulin-dependent, 24 12.4

Graphical network of the top 20 diseases related to Diabetes Mellitus:



Diseases related to Diabetes Mellitus
Sources

Symptoms & Phenotypes for Diabetes Mellitus

About this section

UMLS symptoms related to Diabetes Mellitus:


angina pectoris, tremor, equilibration disorder, symptoms
Sources

Drugs & Therapeutics for Diabetes Mellitus

About this section

Drugs for Diabetes Mellitus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1062)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Linagliptin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 668270-12-0 10096344
2
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 657-24-9 14219 4091
3
Voglibose Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 83480-29-9 444020
4
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 7440-66-6 23994
5
Saxagliptin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 361442-04-8 11243969
6
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-78-2 2244
7
Citalopram Approved Phase 4 59729-33-8 2771
8
Angiotensin II Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
9
Valsartan Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 137862-53-4 60846
10
Ethanol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 64-17-5 702
11
Repaglinide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 135062-02-1 65981
12
Insulin Glargine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 160337-95-1
13
Everolimus Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 159351-69-6 6442177
14
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
15
Paclitaxel Approved, Vet_approved Phase 4,Phase 2,Phase 3 33069-62-4 36314
16
Sirolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 53123-88-9 5284616 6436030 46835353
17
Insulin Detemir Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 169148-63-4 5311023
18
Calcium Carbonate Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 471-34-1
19
Liraglutide Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 204656-20-2 44147092
20
Insulin Lispro Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 133107-64-9
21
Enalapril Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 75847-73-3 5362032 40466924
22
Enalaprilat Approved Phase 4,Phase 3,Phase 2,Not Applicable 76420-72-9 6917719
23
Ezetimibe Approved Phase 4,Phase 3,Phase 2,Not Applicable 163222-33-1 150311
24
Simvastatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 79902-63-9 54454
25
Clopidogrel Approved Phase 4,Phase 3,Phase 2,Not Applicable 120202-66-6, 113665-84-2 60606
26
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 9005-49-6 772 46507594
27
Ticagrelor Approved Phase 4,Phase 3,Not Applicable 274693-27-5 9871419
28
Ticlopidine Approved Phase 4,Phase 3,Phase 2 55142-85-3 5472
29
Pancrelipase Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 53608-75-6
30
Pioglitazone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 111025-46-8 4829
31
Glipizide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 29094-61-9 3478
32
Exenatide Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 141758-74-9 15991534
33
Insulin Aspart Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 116094-23-6 16132418
34
Allopurinol Approved Phase 4,Phase 3,Phase 2,Not Applicable 315-30-0 2094
35
Glimepiride Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 93479-97-1 3476
36
rituximab Approved Phase 4,Phase 1,Phase 2 174722-31-7 10201696
37
Gliclazide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 21187-98-4 3475
38
Acarbose Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1 56180-94-0 441184
39
Glyburide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 10238-21-8 3488
40
Insulin glulisine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 207748-29-6
41
Ramipril Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 87333-19-5 5362129
42
Resveratrol Approved, Experimental, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 501-36-0 445154
43
Alogliptin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 850649-61-5 11450633
44
Vildagliptin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 274901-16-5 6918537
45
Ursodeoxycholic acid Approved, Investigational Phase 4,Phase 2 128-13-2 31401
46
AT-101 Approved, Investigational Phase 4,Not Applicable 90141-22-3, 652-67-5 12597
47
Isosorbide Dinitrate Approved, Investigational Phase 4,Not Applicable 87-33-2 6883
48
Nitric Oxide Approved Phase 4,Phase 2,Not Applicable 10102-43-9 145068 160954
49
Fluvastatin Approved Phase 4 93957-54-1 1548972
50
Mitiglinide Approved, Investigational Phase 4,Phase 3,Phase 1 145375-43-5 3047758

Interventional clinical trials:

(show top 50) (show all 10000)
# Name Status NCT ID Phase Drugs
1 A Comprehensive Intervention for Diabetes and Comorbid Depression in Primary Care Unknown status NCT00939250 Phase 4
2 Effect of Linagliptin on Insulin Sensitivity and Pancreatic Beta Cell Function in Patients With Type 2 Diabetes Mellitus Unknown status NCT02097342 Phase 4 Linagliptin;Placebo;Voglibose
3 The Impact of Rosuvastatin on the Density Score of Coronary Artery Calcification in CAD Patients With Diabetes Mellitus Unknown status NCT02418884 Phase 4 rosuvastatin
4 Diabetes Prevention Program in Schizophrenia [DPPS] Unknown status NCT00182494 Phase 4
5 Prevention of Diabetes Mellitus Development in Women Who Had Already Experienced A Gestational Diabetes Unknown status NCT00265746 Phase 4 Metformin
6 Real-Time Continuous Glucose Monitoring in Pre-School Children With Type-1 Diabetes Mellitus Unknown status NCT01016457 Phase 4
7 Organization Program of DiabEtes INsulIN ManaGement Unknown status NCT01338376 Phase 4 Scilin®M30
8 The Effect of Saxagliptin on Glucose Fluctuation and Immune Regulation in Patients With Type 1 Diabetes Unknown status NCT02307695 Phase 4 Saxagliptin;Insulin
9 Type 2 Diabetes Mellitus and Atherosclerosis Unknown status NCT01250340 Phase 4 Aspirin;Placebo
10 Prospective Randomized Trials of Gastric Bypass Surgery in Patients With Type II Diabetes Mellitus Unknown status NCT00540462 Phase 4
11 Efficacy Study of Escitalopram for Depression in Patients With Diabetes Unknown status NCT00650897 Phase 4 Escitalopram
12 Effects of Valsartan and Aliskiren on Hemostatic Indices in Hypertensive Diabetics Unknown status NCT01095822 Phase 4 Aliskiren + Valsartan
13 Vascular Effects of Sitagliptin in Diabetes Mellitus Unknown status NCT01096277 Phase 4 Sitagliptin;Placebo
14 German Diabetes-Diet-Intervention and Energy Restriction-Trial (DDIET) Unknown status NCT01409330 Phase 4
15 A Double-Blind, Randomized, Parallel, Comparative Study to Evaluate the Efficacy and Safety of an Antidiabetic Agent Repaglinide for the Treatment of Type 2 Diabetes Mellitus Patients Unknown status NCT00336310 Phase 4 Repaglinide
16 Investigation of a Switch From Insulin Therapy to a Metformin & Saxagliptin Combination in Patients With Type 2 Diabetes Mellitus Unknown status NCT01206647 Phase 4 Metformin and Saxagliptin
17 Chronic Treatment With Benfotiamine Restores Endothelial Function in People With Type 2 Diabetes Mellitus Unknown status NCT00446810 Phase 4 Benfotiamine;Placebo
18 Continuous Glucose Monitoring in Patients With Type 2 Diabetes Unknown status NCT00529815 Phase 4
19 Comparison of Diabetes Mellitus and Non-diabetes Mellitus Patients for DES Surface COVERage by OCT Unknown status NCT01021930 Phase 4
20 Thyroid Study Type 2 Diabetes Mellitus (T2DM) Unknown status NCT01379170 Phase 4 Euthyrox (levothyroxine)
21 Comparing Long-acting Insulins During Exercise in Type 1 Diabetes Unknown status NCT01440439 Phase 4 Insulin glargine;Insulin detemir
22 Assessment of Surface Coverage of Two Types of DES in Diabetes Mellitus and Non- Diabetes Mellitus Unknown status NCT01023919 Phase 4
23 Effect of Supplementary Vitamin D in Patients With Diabetes Mellitus and Pulmonary Tuberculosis Unknown status NCT02169570 Phase 4
24 Effects of Liraglutide on ER Stress in Obese Patients With Type 2 Diabetes Unknown status NCT02344186 Phase 4 Liraglutide
25 Metformin and Sitagliptin Therapy for Adult Patients With Type 2 Diabetes Admitted to the General Medical Unit Unknown status NCT02250794 Phase 4 metformin and sitagliptin;insulin glargine and insulin lispro;metformin and sitagliptin;insulin glargine and insulin lispro
26 Glucometer and Mobile-phone Based Data Transfer System in Diabetes Unknown status NCT02769377 Phase 4
27 The Effect of n-3 Fatty Acid Supplementation on Serum Levels, and Gene Expression of type2 Diabetes Patient Unknown status NCT02261545 Phase 4
28 Aspirin and Enalapril in Microalbuminuric Type 2 Diabetes Mellitus Patients Unknown status NCT00427271 Phase 4 aspirin
29 Bone Turnover in Type 2 Diabetes Patients Unknown status NCT00732121 Phase 4 Sitagliptin;Placebo
30 Study to Compare the Effect of Vytorin (Simvastatin/Ezetimibe) 10/20mg Versus Atorvastatin 20mg on ApoB/ApoA1 Ratio in Subjects With Diabetes Unknown status NCT01185236 Phase 4 simvastatin/ezetimibe;atorvastatin 20mg
31 Intervention to Promote Weight Loss in Latinas At-risk for Diabetes Unknown status NCT02088034 Phase 4 Metformin Therapy
32 PRotective Effect on the Coronary Microcirculation of Patients With DIabetes by Clopidogrel or Ticagrelor Unknown status NCT02698618 Phase 4 Randomization
33 Chronic Cold Acclimation Stimulates the Browning of Subcutaneous White Adipose in Patients With Type 2 Diabetes Mellitus Unknown status NCT02775253 Phase 4
34 Mixed Meal Test in Type 1 Diabetes: Optimization of Artificial Pancreas-Pilot Study Unknown status NCT01800734 Phase 4
35 How Does the Diabetes Drug, Pioglitazone, Reduce Protein Loss in the Urine? Unknown status NCT00749047 Phase 4 Pioglitazone
36 Outpatient Discharge Therapy With Saxagliptin+MetforminXR vs GlipizideXL for Type 2 Diabetes With Severe Hyperglycemia Unknown status NCT01267448 Phase 4 Glipizide XL;Saxagliptin + Metformin XR;Metformin XR
37 A Crossover Study With Hexalacton in Patients With Type 1 Diabetes and Microalbuminuria Unknown status NCT00843388 Phase 4 Spironolacton (hexalacton(R));placebo tablet
38 Treatment of Low Blood Sugar With Glucagon Among Patients With Type 1 Diabetes Unknown status NCT02232971 Phase 4 Glucagon
39 A Study on Ca Blocker Versus AII Antagonists in Hypertension With Type 2 Diabetes Unknown status NCT00144144 Phase 4 Angiotensin II receptor antagonists, Calcium channel blocker
40 Multifactorial Intervention in Type 2 Diabetes - Italy Unknown status NCT01240070 Phase 4
41 Comparison of Exenatide vs. Biphasic Insulin Aspart 30 on Glucose Variability in Type 2 Diabetes Unknown status NCT02449603 Phase 4 Exenatide;Biphasic insulin Aspart 30
42 Comparison of TIcagrelor and Clopidogrel in Patients With Coronary Artery diseaSe and Type 2 Diabetes Mellitus (TICS-DM) Unknown status NCT02457130 Phase 4 Ticagrelor;Clopidogrel
43 Effect of SGLT-2 Inhibitor Dapagliflozin on Glycemic Variability in Patients With Diabetes Mellitus Type 2 Unknown status NCT02719756 Phase 4 Metformin;Dapagliflozin;Metformin up-titration
44 Microalbuminuria and Allopurinol in Type 1 Diabetes Unknown status NCT02829177 Phase 4 Allopurinol;Placebo
45 Mechanistic Study of the Systolic Blood Pressure Lowering Effect of Dapagliflozin in Type 2 Diabetes Unknown status NCT02372955 Phase 4 dapagliflozin;glimpiride
46 Immune Intervention With Rituximab to Preserve Beta Cell Function in Early Onset Type 1 Diabetes Unknown status NCT01280682 Phase 4 rituximab
47 ASCEND: A Study of Cardiovascular Events iN Diabetes Unknown status NCT00135226 Phase 4 aspirin;Omega-3-acid Ethyl Esters;Placebo Aspirin;Placebo omega-3-Ethyl Esters
48 Effect of Linagliptin in Comparison With Glimepiride as Add on to Metformin on Postprandial Beta Cell Function, Postprandial Metabolism and Oxidative Stress in Patients With Type 2 Diabetes Mellitus Unknown status NCT01547104 Phase 4 Linagliptin;Glimepiride
49 Effect on Beta Cell Function and Glycaemic Control After Insulin and Exenatide Sequential Therapy Unknown status NCT02129985 Phase 4 Exenatide;Metformin
50 Effect of Modifying Anti-platelet Treatment to Ticagrelor in Patients With Diabetes and Low Response to Clopidogrel Unknown status NCT01643031 Phase 4 Ticagrelor;Continued clopidogrel

Search NIH Clinical Center for Diabetes Mellitus

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: diabetes mellitus

Sources

Genetic Tests for Diabetes Mellitus

About this section

Genetic tests related to Diabetes Mellitus:

# Genetic test Affiliating Genes
1 Diabetes Mellitus 29
Sources

Anatomical Context for Diabetes Mellitus

About this section

MalaCards organs/tissues related to Diabetes Mellitus:

41
Heart, Kidney, Endothelial, Testes, Pancreas, Liver, Bone
Sources

Publications for Diabetes Mellitus

About this section

Articles related to Diabetes Mellitus:

(show top 50) (show all 11003)
# Title Authors Year
1
Assessment of association between lipoxygenase genes variants in elderly Greek population and type 2 diabetes mellitus. ( 29392977 )
2018
2
Nanoliposomal Resveratrol as a Novel Approach to Treatment of Diabetes Mellitus. ( 29442719 )
2018
3
Increasing prevalence of type 2 diabetes mellitus and impact of ethnicity in north Sudan. ( 29203255 )
2018
4
Maternal lipids, BMI and IL-17/IL-35 imbalance in concurrent gestational diabetes mellitus and preeclampsia. ( 29977366 )
2018
5
Naringin prevents bone loss in a rat model of type 1 Diabetes mellitus. ( 29208404 )
2018
6
Hemoglobin levels during the first trimester of pregnancy are associated with the risk of gestational diabetes mellitus, pre-eclampsia and preterm birth in Chinese women: a retrospective study. ( 29940874 )
2018
7
Maturity-onset diabetes of the young (MODY) as a model for elucidating the multifactorial origin of type 2 diabetes mellitus. ( 29406598 )
2018
8
Role of omentin 1 and IL-6 in type 2 diabetes mellitus patients with diabetic nephropathy. ( 28864059 )
2018
9
Disseminated Invasive Mycobacterium marinum Infection Involving the Lung of a Patient with Diabetes Mellitus. ( 29637757 )
2018
10
Quality assessment of recent evidence-based clinical practice guidelines for management of type 2 diabetes mellitus in adults using the AGREE II instrument. ( 28948654 )
2018
11
Tunable injectable alginate-based hydrogel for cell therapy in Type 1 Diabetes Mellitus. ( 28962846 )
2018
12
Sodium-glucose co-transporter 2 (SGLT2) inhibitors as add-on therapy to insulin for type 1 diabetes mellitus: Systematic review and meta-analysis of randomized controlled trials. ( 29451721 )
2018
13
History of mood or anxiety disorders and risk of gestational diabetes mellitus in a population-based cohort. ( 29120506 )
2018
14
Maternal gestational diabetes mellitus: is it associated with long-term pediatric ophthalmic morbidity of the offspring? ( 29429374 )
2018
15
The influence of prehypertension, hypertension, and glycated hemoglobin on the development of type 2 diabetes mellitus in prediabetes: the Korean Genome and Epidemiology Study (KoGES). ( 29380232 )
2018
16
A new promising simultaneous approach for attenuating type II diabetes mellitus induced neuropathic pain in rats: iNOS inhibition and neuroregeneration. ( 29154836 )
2018
17
Vitamin D status and oxidative stress in diabetes mellitus. ( 29974854 )
2018
18
Onset of fulminant type 1 diabetes mellitus under immunotolerance status after long-term therapy for chronic inflammatory demyelinating polyneuropathy. ( 29905029 )
2018
19
Extracellular vesicles in obesity and diabetes mellitus. ( 29175307 )
2018
20
The interaction between apolipoprotein B insertion/deletion polymorphism and macronutrient intake on lipid profile and serum leptin and ghrelin levels in type 2 diabetes mellitus patients. ( 29374794 )
2018
21
The FTO variant is associated with chronic complications of diabetes mellitus in Czech population. ( 29154870 )
2018
22
Agenesis of dorsal pancreas in a young adult: a rare cause of diabetes mellitus. ( 29444795 )
2018
23
Osteoprotegerin concentration is associated with the presence and severity of peripheral arterial disease in type 2 diabetes mellitus. ( 29313442 )
2018
24
Visceral leishmaniasis in a patient with diabetes mellitus type 2 and discrete bicytopenia. ( 29375842 )
2018
25
Unmasking of poorly controlled diabetes mellitus by pulmonary nocardiosis. ( 29776946 )
2018
26
Incidence of type 2 diabetes mellitus and hyperlipidemia in patients prescribed dasatinib or nilotinib as first- or second-line therapy for chronic myelogenous leukemia in the US. ( 29095654 )
2018
27
Role of silibinin in the management of diabetes mellitus and its complications. ( 29978427 )
2018
28
Level of maternal triglycerides is a predictor of fetal macrosomia in non-obese pregnant women with gestational diabetes mellitus. ( 29398554 )
2018
29
The value of fast-acting insulin aspart compared with insulin aspart for patients with diabetes mellitus treated with bolus insulin from a UK health care system perspective. ( 29977497 )
2018
30
Pulse pressure amplification and cardiac autonomic dysfunction in patients with type 2 diabetes mellitus. ( 29789692 )
2018
31
Association between chemerin rs17173608 and rs4721 gene polymorphisms and gestational diabetes mellitus in Iranian pregnant women. ( 29360607 )
2018
32
Barriers to insulin initiation in elderly patients with type 2 diabetes mellitus in Brazil. ( 28864058 )
2018
33
Plasma Levels of Myonectin But Not Myostatin or Fibroblast-Derived Growth Factor 21 Are Associated with Insulin Resistance in Adult Humans without Diabetes Mellitus. ( 29445355 )
2018
34
CD36 gene variants is associated with type 2 diabetes mellitus through the interaction of obesity in rural Chinese adults. ( 29572193 )
2018
35
Genetic mutations associated with neonatal diabetes mellitus in Omani patients. ( 29329106 )
2018
36
Efficacy of Growth Hormone Treatment in Children with Type 1 Diabetes Mellitus and Growth Hormone Deficiency-An Analysis of KIGS Data. ( 29656861 )
2018
37
Different Indexes of Glycemic Variability as Identifiers of Patients with Risk of Hypoglycemia in Type 2 Diabetes Mellitus. ( 29451006 )
2018
38
Neonatal Diabetes Mellitus: An Update on Diagnosis and Management. ( 29406006 )
2018
39
Impaired Vascular Redox Signaling in the Vascular Complications of Obesity and Diabetes Mellitus. ( 29084432 )
2018
40
Association of hypoglycaemia and risk of cardiac arrhythmia in patients with diabetes mellitus: A systematic review and meta-analysis. ( 29740922 )
2018
41
Glucagon-like peptide-1 receptor agonists reduced the low-density lipoprotein cholesterol in Japanese patients with type 2 diabetes mellitus treated with statins. ( 29217412 )
2018
42
Definition, Classification and Diagnosis of Diabetes Mellitus. ( 29975979 )
2018
43
Exploration of predictive metabolic factors for gestational diabetes mellitus in Japanese women using metabolomic analysis. ( 29956893 )
2018
44
Analysis of the correlation of gestational diabetes mellitus and peripheral ferritin with iron levels in early pregnancy. ( 29442476 )
2018
45
Combined creatinine-cystatin C CKD-EPI equation significantly underestimates measured glomerular filtration rate in people with type 2 diabetes mellitus. ( 29331592 )
2018
46
Hyperglycemia and diabetes mellitus are related to vestibular organs dysfunction: truth or suggestion? A literature review. ( 29936650 )
2018
47
Effectiveness of vildagliptin as add-on to metformin monotherapy among uncontrolled type 2 diabetes mellitus patients in a real-world setting. ( 28418203 )
2018
48
Risk of acute epiglottitis in patients with preexisting diabetes mellitus: A population-based case-control study. ( 29889887 )
2018
49
Association between depression and persistence with oral antihyperglycemic drugs in type 2 diabetes mellitus patients in Germany. ( 29291478 )
2018
50
Inequalities in glycaemic control, hypoglycaemia and diabetic ketoacidosis according to socio-economic status and area-level deprivation in Type 1 diabetes mellitus: a systematic review. ( 28945942 )
2018
Sources

Variations for Diabetes Mellitus

About this section

ClinVar genetic disease variations for Diabetes Mellitus:

6
(show all 18)
# Gene Variation Type Significance SNP ID Assembly Location
1 KCNJ11 NM_000525.3(KCNJ11): c.601C> T (p.Arg201Cys) single nucleotide variant Pathogenic rs80356625 GRCh37 Chromosome 11, 17409038: 17409038
2 KCNJ11 NM_000525.3(KCNJ11): c.601C> T (p.Arg201Cys) single nucleotide variant Pathogenic rs80356625 GRCh38 Chromosome 11, 17387491: 17387491
3 KCNJ11 NM_000525.3(KCNJ11): c.964G> A (p.Glu322Lys) single nucleotide variant Pathogenic rs193929355 GRCh37 Chromosome 11, 17408675: 17408675
4 KCNJ11 NM_000525.3(KCNJ11): c.964G> A (p.Glu322Lys) single nucleotide variant Pathogenic rs193929355 GRCh38 Chromosome 11, 17387128: 17387128
5 ABCC8 NM_000352.4(ABCC8): c.1562G> A (p.Arg521Gln) single nucleotide variant Uncertain significance rs368114790 GRCh37 Chromosome 11, 17464335: 17464335
6 ABCC8 NM_000352.4(ABCC8): c.1562G> A (p.Arg521Gln) single nucleotide variant Uncertain significance rs368114790 GRCh38 Chromosome 11, 17442788: 17442788
7 KCNJ11 NM_000525.3(KCNJ11): c.988T> C (p.Tyr330His) single nucleotide variant Pathogenic rs587783675 GRCh37 Chromosome 11, 17408651: 17408651
8 KCNJ11 NM_000525.3(KCNJ11): c.988T> C (p.Tyr330His) single nucleotide variant Pathogenic rs587783675 GRCh38 Chromosome 11, 17387104: 17387104
9 KCNJ11 NM_000525.3(KCNJ11): c.685G> A (p.Glu229Lys) single nucleotide variant Pathogenic rs587783673 GRCh37 Chromosome 11, 17408954: 17408954
10 KCNJ11 NM_000525.3(KCNJ11): c.685G> A (p.Glu229Lys) single nucleotide variant Pathogenic rs587783673 GRCh38 Chromosome 11, 17387407: 17387407
11 KCNJ11 NM_000525.3(KCNJ11): c.679G> A (p.Glu227Lys) single nucleotide variant Pathogenic rs587783672 GRCh37 Chromosome 11, 17408960: 17408960
12 KCNJ11 NM_000525.3(KCNJ11): c.679G> A (p.Glu227Lys) single nucleotide variant Pathogenic rs587783672 GRCh38 Chromosome 11, 17387413: 17387413
13 KCNJ11 NM_000525.3(KCNJ11): c.498C> G (p.Cys166Trp) single nucleotide variant Likely pathogenic rs587783669 GRCh37 Chromosome 11, 17409141: 17409141
14 KCNJ11 NM_000525.3(KCNJ11): c.498C> G (p.Cys166Trp) single nucleotide variant Likely pathogenic rs587783669 GRCh38 Chromosome 11, 17387594: 17387594
15 KCNJ11 NM_000525.3(KCNJ11): c.463G> A (p.Val155Met) single nucleotide variant Uncertain significance rs587783668 GRCh37 Chromosome 11, 17409176: 17409176
16 KCNJ11 NM_000525.3(KCNJ11): c.463G> A (p.Val155Met) single nucleotide variant Uncertain significance rs587783668 GRCh38 Chromosome 11, 17387629: 17387629
17 MEN1 NM_000244.3(MEN1): c.669+1delG deletion Pathogenic rs1057518903 GRCh37 Chromosome 11, 64575362: 64575362
18 MEN1 NM_000244.3(MEN1): c.669+1delG deletion Pathogenic rs1057518903 GRCh38 Chromosome 11, 64807890: 64807890

Copy number variations for Diabetes Mellitus from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 110220 17 3154257 3410803 Deletion HNF1b Diabetes mellitus
2 110369 17 31923035 33323544 Deletion HNF1B Diabetes mellitus
3 110541 17 33120546 33179209 Deletion HNF1B Diabetes mellitus
4 203632 1 158846514 158883705 Rearrangement SLAM Diabetes mellitus
5 225144 7 43300000 45400000 Gain or loss GCK Diabetes mellitus
Sources

Expression for Diabetes Mellitus

About this section
Search GEO for disease gene expression data for Diabetes Mellitus.
Sources

Pathways for Diabetes Mellitus

About this section

Pathways related to Diabetes Mellitus according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Aldosterone synthesis and secretion 37
Show member pathways
 12.58 ABCC8 INS KCNJ11 MEN1 PDX1
2
MicroRNAs in cancer 37
12.03 MIR145 MIR155 MIR30E MIR375 MIR99A
3
Parkinsons Disease Pathway 1
11.36 MIR132 MIR30E MIR375
4
Type II diabetes mellitus 37 1
Show member pathways
 11.24 ABCC8 INS KCNJ11 PDX1
5
FOXA2 and FOXA3 transcription factor networks 1
10.57 ABCC8 INS KCNJ11 PDX1
Sources

GO Terms for Diabetes Mellitus

About this section

Cellular components related to Diabetes Mellitus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.28 INS MIR132 MIR134 MIR140 MIR155 MIR197
2 inward rectifying potassium channel GO:0008282 8.96 ABCC8 KCNJ11

Biological processes related to Diabetes Mellitus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 miRNA mediated inhibition of translation GO:0035278 9.43 MIR132 MIR134 MIR145
2 type B pancreatic cell differentiation GO:0003309 9.16 MEN1 PDX1
3 glucose metabolic process GO:0006006 9.13 INS KCNJ11 PDX1
4 gene silencing by miRNA GO:0035195 9.02 MIR132 MIR140 MIR145 MIR155 MIR30E

Molecular functions related to Diabetes Mellitus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATP-activated inward rectifier potassium channel activity GO:0015272 9.16 ABCC8 KCNJ11
2 RNA polymerase II core binding GO:0000993 9.13 MIR140 MIR145 MIR375
3 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.1 MIR132 MIR134 MIR140 MIR145 MIR155 MIR30E
Sources

Sources for Diabetes Mellitus

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....