IDDM21
MCID: DBT079
MIFTS: 16

Diabetes Mellitus, Insulin-Dependent, 21 (IDDM21)

Categories: Genetic diseases, Metabolic diseases

Aliases & Classifications for Diabetes Mellitus, Insulin-Dependent, 21

MalaCards integrated aliases for Diabetes Mellitus, Insulin-Dependent, 21:

Name: Diabetes Mellitus, Insulin-Dependent, 21 56 13 71
Type 1 Diabetes Mellitus 21 12 15
Iddm21 56 12
Insulin-Dependent Diabetes Mellitus 21 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0110758
OMIM 56 612521
ICD10 32 E10
MedGen 41 C2675865
UMLS 71 C2675865

Summaries for Diabetes Mellitus, Insulin-Dependent, 21

Disease Ontology : 12 A type 1 diabetes mellitus that has material basis in mutation of the locus at chromosome 6q25.

MalaCards based summary : Diabetes Mellitus, Insulin-Dependent, 21, is also known as type 1 diabetes mellitus 21. An important gene associated with Diabetes Mellitus, Insulin-Dependent, 21 is TAGAP (T Cell Activation RhoGTPase Activating Protein), and among its related pathways/superpathways are NF-kappaB Signaling and Cell adhesion molecules (CAMs). Related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

More information from OMIM: 612521

Symptoms & Phenotypes for Diabetes Mellitus, Insulin-Dependent, 21

Clinical features from OMIM:

612521

GenomeRNAi Phenotypes related to Diabetes Mellitus, Insulin-Dependent, 21 according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-142 9.36 NTAN1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.36 NTAN1 PDCD1LG2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.36 NTAN1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.36 PDCD1LG2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-180 9.36 NTAN1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-200 9.36 PDCD1LG2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-26 9.36 NTAN1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.36 NTAN1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.36 NTAN1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-90 9.36 PDCD1LG2

Drugs & Therapeutics for Diabetes Mellitus, Insulin-Dependent, 21

Search Clinical Trials , NIH Clinical Center for Diabetes Mellitus, Insulin-Dependent, 21

Genetic Tests for Diabetes Mellitus, Insulin-Dependent, 21

Anatomical Context for Diabetes Mellitus, Insulin-Dependent, 21

Publications for Diabetes Mellitus, Insulin-Dependent, 21

Articles related to Diabetes Mellitus, Insulin-Dependent, 21:

# Title Authors PMID Year
1
Shared and distinct genetic variants in type 1 diabetes and celiac disease. 56
19073967 2008
2
Prevalence and clinical profile of celiac disease in type 1 diabetes mellitus in north India. 61
21261730 2011
3
The influence of type-1 diabetes mellitus on dentition and oral health in children and adolescents. 61
18581583 2008
4
Autoantibodies in autoimmune polyendocrine syndrome type II. 61
12092456 2002

Variations for Diabetes Mellitus, Insulin-Dependent, 21

Expression for Diabetes Mellitus, Insulin-Dependent, 21

Search GEO for disease gene expression data for Diabetes Mellitus, Insulin-Dependent, 21.

Pathways for Diabetes Mellitus, Insulin-Dependent, 21

Pathways related to Diabetes Mellitus, Insulin-Dependent, 21 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.47 PDCD1LG2 EOMES
2 10.79 PDCD1LG2 MADCAM1

GO Terms for Diabetes Mellitus, Insulin-Dependent, 21

Sources for Diabetes Mellitus, Insulin-Dependent, 21

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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