IDDM21
MCID: DBT079
MIFTS: 31

Diabetes Mellitus, Insulin-Dependent, 21 (IDDM21)

Categories: Endocrine diseases, Genetic diseases, Metabolic diseases, Rare diseases

Aliases & Classifications for Diabetes Mellitus, Insulin-Dependent, 21

MalaCards integrated aliases for Diabetes Mellitus, Insulin-Dependent, 21:

Name: Diabetes Mellitus, Insulin-Dependent, 21 56 13 71
Type 1 Diabetes Mellitus 21 12 15
Iddm21 56 12
Insulin-Dependent Diabetes Mellitus 21 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0110758
OMIM 56 612521
ICD10 32 E10
MedGen 41 C2675865
UMLS 71 C2675865

Summaries for Diabetes Mellitus, Insulin-Dependent, 21

Disease Ontology : 12 A type 1 diabetes mellitus that has material basis in mutation of the locus at chromosome 6q25.

MalaCards based summary : Diabetes Mellitus, Insulin-Dependent, 21, also known as type 1 diabetes mellitus 21, is related to primary cutaneous diffuse large b-cell lymphoma, leg type and primary mediastinal large b-cell lymphoma. An important gene associated with Diabetes Mellitus, Insulin-Dependent, 21 is TAGAP (T Cell Activation RhoGTPase Activating Protein), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

More information from OMIM: 612521

Related Diseases for Diabetes Mellitus, Insulin-Dependent, 21

Diseases in the Diabetes Mellitus, Insulin-Dependent family:

Diabetes Mellitus, Insulin-Dependent, 2 Diabetes Mellitus, Insulin-Dependent, 3
Diabetes Mellitus, Insulin-Dependent, 4 Diabetes Mellitus, Insulin-Dependent, 5
Diabetes Mellitus, Insulin-Dependent, 7 Diabetes Mellitus, Insulin-Dependent, 8
Diabetes Mellitus, Insulin-Dependent, 11 Diabetes Mellitus, Insulin-Dependent, 13
Diabetes Mellitus, Insulin-Dependent, 12 Diabetes Mellitus, Insulin-Dependent, 15
Diabetes Mellitus, Insulin-Dependent, 6 Diabetes Mellitus, Insulin-Dependent, 10
Diabetes Mellitus, Insulin-Dependent, 17 Diabetes Mellitus, Insulin-Dependent, 18
Diabetes Mellitus, Insulin-Dependent, 19 Diabetes Mellitus, Insulin-Dependent, 20
Diabetes Mellitus, Insulin-Dependent, 21 Diabetes Mellitus, Insulin-Dependent, 22
Diabetes Mellitus, Insulin-Dependent, 23 Diabetes Mellitus, Insulin-Dependent, 24

Diseases related to Diabetes Mellitus, Insulin-Dependent, 21 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 primary cutaneous diffuse large b-cell lymphoma, leg type 10.3 PDCD1LG2 CD274
2 primary mediastinal large b-cell lymphoma 10.3 PDCD1LG2 CD274
3 testicular lymphoma 10.2 PDCD1LG2 PDCD1 CD274
4 gray zone lymphoma 10.2 PDCD1LG2 CD274
5 myopathy, distal, 1 10.2 PDCD1LG2 PDCD1 CD274
6 macular degeneration, age-related, 8 10.1 TBX21 EOMES CD28
7 aneruptive fever 10.1 TBX21 GATA3 CD28
8 angioimmunoblastic t-cell lymphoma 10.0 TBX21 PDCD1LG2 PDCD1 CD28
9 gastroesophageal junction adenocarcinoma 10.0 PDCD1 CD274
10 malignant dermis tumor 9.9 CTLA4 CD274
11 malignant skin fibrous histiocytoma 9.9 CTLA4 CD274
12 sympathetic ophthalmia 9.9 VCAM1 PDCD1 CTLA4
13 filariasis 9.9 PDCD1LG2 GATA3 CTLA4
14 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 9.8 TBX21 CTLA4 CD28
15 vitiligo-associated multiple autoimmune disease susceptibility 1 9.8 PDCD1 CTLA4 CD274
16 peripheral t-cell lymphoma 9.7 PDCD1 GATA3 CD274 AKT1
17 mixed oligodendroglioma-astrocytoma 9.7 PDCD1 CD276 CD274
18 autoimmune cardiomyopathy 9.7 PDCD1LG2 PDCD1 CTLA4 CD274
19 inflammatory bowel disease 18 9.7 CTLA4 CD28
20 sezary's disease 9.6 GATA3 CTLA4 CD28
21 autoimmune peripheral neuropathy 9.6 CD28 CD276
22 thymus gland disease 9.6 CTLA4 CD274 AKT1
23 thymus cancer 9.6 CTLA4 CD274 AKT1
24 spinal chordoma 9.6 CD274 AKT1
25 autoimmune disease of cardiovascular system 9.6 PDCD1LG2 CTLA4 CD28 CD274
26 autoimmune disease of central nervous system 9.6 VCAM1 TBX21 CTLA4 CD28
27 adult t-cell leukemia 9.5 CTLA4 CD274 AKT1
28 viral infectious disease 9.5 PDCD1 CTLA4 CD28 CD274
29 exanthem 9.5 PDCD1 CTLA4 CD274 AKT1
30 gastric adenocarcinoma 9.4 PDCD1LG2 PDCD1 GATA3 CD274 AKT1
31 celiac disease 1 9.4 TBX21 TAGAP GCG CTLA4 CD28
32 bone inflammation disease 9.4 MMP13 CTLA4 CD28
33 dermatitis, atopic 9.4 VCAM1 TBX21 GATA3 CTLA4 CD28
34 aplastic anemia 9.2 VCAM1 TBX21 PDCD1 GATA3 CTLA4 CD28
35 multiple sclerosis 9.1 VCAM1 TAGAP PDCD1 CTLA4 CD28 CD274
36 diabetes mellitus, insulin-dependent 8.9 VCAM1 PDCD1 GCG CTLA4 CD28 AKT1
37 myeloma, multiple 8.8 VCAM1 IL6R CTLA4 CD28 CD274 AKT1
38 squamous cell carcinoma, head and neck 8.7 PDCD1 MMP13 IL6R CTLA4 CD274 AKT1
39 rheumatoid arthritis 8.7 VCAM1 TAGAP PDCD1 MMP13 IL6R CTLA4
40 cone-rod dystrophy 2 8.6 TNFRSF14 CTLA4 CD28 CD276 AKT1
41 inflammatory bowel disease 8.5 VCAM1 TBX21 MMP13 MADCAM1 IL6R GCG
42 systemic lupus erythematosus 7.9 VCAM1 TBX21 PDCD1 GATA3 CTLA4 CD28

Graphical network of the top 20 diseases related to Diabetes Mellitus, Insulin-Dependent, 21:



Diseases related to Diabetes Mellitus, Insulin-Dependent, 21

Symptoms & Phenotypes for Diabetes Mellitus, Insulin-Dependent, 21

Clinical features from OMIM:

612521

GenomeRNAi Phenotypes related to Diabetes Mellitus, Insulin-Dependent, 21 according to GeneCards Suite gene sharing:

26 (show all 28)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.19 TBX21
2 Increased shRNA abundance (Z-score > 2) GR00366-A-101 10.19 CD274
3 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.19 MMP13
4 Increased shRNA abundance (Z-score > 2) GR00366-A-12 10.19 CD274
5 Increased shRNA abundance (Z-score > 2) GR00366-A-120 10.19 CD274
6 Increased shRNA abundance (Z-score > 2) GR00366-A-125 10.19 MMP13 RAN
7 Increased shRNA abundance (Z-score > 2) GR00366-A-135 10.19 RAN
8 Increased shRNA abundance (Z-score > 2) GR00366-A-146 10.19 RAN
9 Increased shRNA abundance (Z-score > 2) GR00366-A-158 10.19 RAN
10 Increased shRNA abundance (Z-score > 2) GR00366-A-159 10.19 RAN TBX21
11 Increased shRNA abundance (Z-score > 2) GR00366-A-166 10.19 RAN
12 Increased shRNA abundance (Z-score > 2) GR00366-A-173 10.19 TBX21
13 Increased shRNA abundance (Z-score > 2) GR00366-A-174 10.19 MMP13
14 Increased shRNA abundance (Z-score > 2) GR00366-A-177 10.19 RAN
15 Increased shRNA abundance (Z-score > 2) GR00366-A-180 10.19 CD274
16 Increased shRNA abundance (Z-score > 2) GR00366-A-191 10.19 CD274
17 Increased shRNA abundance (Z-score > 2) GR00366-A-192 10.19 TBX21
18 Increased shRNA abundance (Z-score > 2) GR00366-A-201 10.19 RAN
19 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.19 CD274
20 Increased shRNA abundance (Z-score > 2) GR00366-A-30 10.19 CD274 RAN
21 Increased shRNA abundance (Z-score > 2) GR00366-A-32 10.19 CD274 MMP13 RAN TBX21
22 Increased shRNA abundance (Z-score > 2) GR00366-A-6 10.19 RAN
23 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.19 RAN
24 Increased shRNA abundance (Z-score > 2) GR00366-A-70 10.19 RAN
25 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.19 TBX21
26 Increased shRNA abundance (Z-score > 2) GR00366-A-78 10.19 RAN
27 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.19 CD274 TBX21
28 Reduced mammosphere formation GR00396-S 9.17 CD28 HOXD13 IL6R MMP13 NTAN1 RAN

MGI Mouse Phenotypes related to Diabetes Mellitus, Insulin-Dependent, 21:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.17 AKT1 CD274 CD276 CD28 CTLA4 EOMES
2 cellular MP:0005384 10.14 AKT1 CD274 CD28 EOMES GATA3 IL6R
3 homeostasis/metabolism MP:0005376 10.1 AKT1 CD274 CD276 CD28 CTLA4 EOMES
4 endocrine/exocrine gland MP:0005379 10.02 AKT1 CD28 CTLA4 GATA3 HOXD13 IL6R
5 immune system MP:0005387 10 AKT1 CD274 CD276 CD28 CTLA4 EOMES
6 neoplasm MP:0002006 9.5 AKT1 CD28 EOMES IL6R PDCD1 PDCD1LG2
7 skeleton MP:0005390 9.28 AKT1 CD274 CD276 CTLA4 EOMES GATA3

Drugs & Therapeutics for Diabetes Mellitus, Insulin-Dependent, 21

Search Clinical Trials , NIH Clinical Center for Diabetes Mellitus, Insulin-Dependent, 21

Genetic Tests for Diabetes Mellitus, Insulin-Dependent, 21

Anatomical Context for Diabetes Mellitus, Insulin-Dependent, 21

Publications for Diabetes Mellitus, Insulin-Dependent, 21

Articles related to Diabetes Mellitus, Insulin-Dependent, 21:

# Title Authors PMID Year
1
Shared and distinct genetic variants in type 1 diabetes and celiac disease. 56
19073967 2008
2
Prevalence and clinical profile of celiac disease in type 1 diabetes mellitus in north India. 61
21261730 2011
3
The influence of type-1 diabetes mellitus on dentition and oral health in children and adolescents. 61
18581583 2008
4
Autoantibodies in autoimmune polyendocrine syndrome type II. 61
12092456 2002

Variations for Diabetes Mellitus, Insulin-Dependent, 21

Expression for Diabetes Mellitus, Insulin-Dependent, 21

Search GEO for disease gene expression data for Diabetes Mellitus, Insulin-Dependent, 21.

Pathways for Diabetes Mellitus, Insulin-Dependent, 21

Pathways related to Diabetes Mellitus, Insulin-Dependent, 21 according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.88 VCAM1 TNFRSF14 PDCD1LG2 PDCD1 MADCAM1 IL6R
2
Show member pathways
13.24 VCAM1 TNFRSF14 PDCD1LG2 PDCD1 MADCAM1 CTLA4
3
Show member pathways
12.39 PDCD1 GATA3 CTLA4 CD28 CD274 AKT1
4
Show member pathways
12.04 TNFRSF14 PDCD1LG2 PDCD1 CTLA4 CD28 CD274
5 11.93 VCAM1 PDCD1LG2 PDCD1 MADCAM1 CTLA4 CD28
6
Show member pathways
11.89 TBX21 IL6R GATA3 CD28
7 11.84 VCAM1 TBX21 PDCD1LG2 PDCD1 GATA3 EOMES
8 11.79 VCAM1 IL6R GATA3 AKT1
9
Show member pathways
11.77 PDCD1LG2 PDCD1 CD274
10 11.63 TBX21 GATA3 AKT1
11 11.6 TBX21 GATA3 EOMES
12
Show member pathways
11.57 TBX21 GATA3 CTLA4
13 11.52 CTLA4 CD28 AKT1
14 11.26 TNFRSF14 PDCD1LG2 PDCD1 CTLA4 CD28 CD276
15 11.14 TBX21 GATA3 EOMES
16 11.11 PDCD1 CTLA4 CD28 AKT1

GO Terms for Diabetes Mellitus, Insulin-Dependent, 21

Cellular components related to Diabetes Mellitus, Insulin-Dependent, 21 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.28 VCAM1 TNFRSF14 PDCD1LG2 PDCD1 IL6R CTLA4
2 protein complex involved in cell adhesion GO:0098636 8.96 CTLA4 CD28

Biological processes related to Diabetes Mellitus, Insulin-Dependent, 21 according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.88 VCAM1 IL6R GATA3 AKT1
2 cell surface receptor signaling pathway GO:0007166 9.83 TNFRSF14 PDCD1LG2 CD28 CD274
3 regulation of immune response GO:0050776 9.8 VCAM1 TBX21 MADCAM1 CD276
4 adaptive immune response GO:0002250 9.8 TNFRSF14 PDCD1LG2 PDCD1 EOMES CTLA4 CD274
5 immune response GO:0006955 9.8 TNFRSF14 PDCD1LG2 MADCAM1 CTLA4 CD28 CD276
6 T cell receptor signaling pathway GO:0050852 9.76 GATA3 CTLA4 CD28 CD276
7 immune system process GO:0002376 9.76 TNFRSF14 PDCD1LG2 PDCD1 GATA3 EOMES CTLA4
8 humoral immune response GO:0006959 9.65 PDCD1 GATA3 CD28
9 leukocyte tethering or rolling GO:0050901 9.61 VCAM1 MADCAM1
10 negative regulation of T cell proliferation GO:0042130 9.61 PDCD1LG2 CTLA4 CD274
11 TOR signaling GO:0031929 9.6 GATA3 AKT1
12 regulation of regulatory T cell differentiation GO:0045589 9.59 CTLA4 CD28
13 negative regulation of immune response GO:0050777 9.58 PDCD1 CTLA4
14 negative regulation of interleukin-2 production GO:0032703 9.57 TBX21 GATA3
15 negative regulation of interleukin-10 production GO:0032693 9.56 PDCD1LG2 CD274
16 regulation of T cell proliferation GO:0042129 9.55 CTLA4 CD28
17 negative regulation of activated T cell proliferation GO:0046007 9.54 PDCD1LG2 CD274
18 negative regulation of interferon-gamma production GO:0032689 9.54 PDCD1LG2 GATA3 CD274
19 positive regulation of isotype switching to IgG isotypes GO:0048304 9.51 TBX21 CD28
20 lymphocyte migration GO:0072676 9.4 TBX21 GATA3
21 positive regulation of T cell proliferation GO:0042102 9.35 VCAM1 PDCD1LG2 CD28 CD276 CD274
22 T cell costimulation GO:0031295 9.17 TNFRSF14 PDCD1LG2 PDCD1 CTLA4 CD28 CD274

Sources for Diabetes Mellitus, Insulin-Dependent, 21

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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