IDDM22
MCID: DBT032
MIFTS: 31

Diabetes Mellitus, Insulin-Dependent, 22 (IDDM22)

Categories: Genetic diseases, Metabolic diseases

Aliases & Classifications for Diabetes Mellitus, Insulin-Dependent, 22

MalaCards integrated aliases for Diabetes Mellitus, Insulin-Dependent, 22:

Name: Diabetes Mellitus, Insulin-Dependent, 22 56 73 29 13 71
Iddm22 56 12 73
Type 1 Diabetes Mellitus 22 12 15
Diabetes Mellitus, Insulin-Dependent, Type 22 39
Insulin-Dependent Diabetes Mellitus 22 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0110759
OMIM 56 612522
MeSH 43 D003922
ICD10 32 E10
MedGen 41 C2675864
UMLS 71 C2675864

Summaries for Diabetes Mellitus, Insulin-Dependent, 22

UniProtKB/Swiss-Prot : 73 Diabetes mellitus, insulin-dependent, 22: A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.

MalaCards based summary : Diabetes Mellitus, Insulin-Dependent, 22, also known as iddm22, is related to submandibular gland cancer and mesangial proliferative glomerulonephritis. An important gene associated with Diabetes Mellitus, Insulin-Dependent, 22 is CCR5 (C-C Motif Chemokine Receptor 5), and among its related pathways/superpathways are Integrin Pathway and Akt Signaling. Affiliated tissues include eye, kidney and heart.

Disease Ontology : 12 A type 1 diabetes mellitus that has material basis in mutation of the CCR5 gene on chromosome 3p21.31.

More information from OMIM: 612522

Related Diseases for Diabetes Mellitus, Insulin-Dependent, 22

Diseases in the Diabetes Mellitus, Insulin-Dependent, 20 family:

Diabetes Mellitus, Insulin-Dependent, 2 Diabetes Mellitus, Insulin-Dependent, 3
Diabetes Mellitus, Insulin-Dependent, 4 Diabetes Mellitus, Insulin-Dependent, 5
Diabetes Mellitus, Insulin-Dependent, 7 Diabetes Mellitus, Insulin-Dependent, 8
Diabetes Mellitus, Insulin-Dependent, 11 Diabetes Mellitus, Insulin-Dependent, 13
Diabetes Mellitus, Insulin-Dependent, 12 Diabetes Mellitus, Insulin-Dependent, 15
Diabetes Mellitus, Insulin-Dependent, 6 Diabetes Mellitus, Insulin-Dependent, 10
Diabetes Mellitus, Insulin-Dependent, 17 Diabetes Mellitus, Insulin-Dependent, 18
Diabetes Mellitus, Insulin-Dependent, 19 Diabetes Mellitus, Insulin-Dependent, 21
Diabetes Mellitus, Insulin-Dependent, 22 Diabetes Mellitus, Insulin-Dependent, 23
Diabetes Mellitus, Insulin-Dependent, 24

Diseases related to Diabetes Mellitus, Insulin-Dependent, 22 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 submandibular gland cancer 10.1 CCR5 CCL3
2 mesangial proliferative glomerulonephritis 10.1 CCR5 CCL3
3 proliferative glomerulonephritis 10.1 CCR5 CCL3
4 crescentic glomerulonephritis 10.0 CCR5 CCL3
5 tick-borne encephalitis 10.0 CCR5 CCL3
6 autoimmune uveitis 10.0 CCR5 CCL3
7 parasitic protozoa infectious disease 9.9 CCR5 CCL3
8 west nile virus infection 9.9 CCR5 CCL5
9 toxoplasmosis 9.9 CCR5 CCL3
10 oral lichen planus 9.8 CCR5 CCL5
11 vaginitis 9.8 CCR5 CCL5
12 genital herpes 9.8 CCR5 CCL5
13 vaginal disease 9.8 CCR5 CCL5
14 allergic encephalomyelitis 9.8 CCL5 CCL3
15 respiratory syncytial virus infectious disease 9.8 CCL5 CCL3
16 stachybotrys chartarum 9.8 CCL5 CCL3
17 ileitis 9.8 CCR5 CCL5
18 african tick-bite fever 9.8 CCL5 CCL3
19 chronic eosinophilic pneumonia 9.8 CCL5 CCL3
20 radiculopathy 9.7 CCL5 CCL3
21 yellow fever 9.7 CCR5 CCL5
22 mast-cell leukemia 9.7 CCL5 CCL3
23 pulmonary eosinophilia 9.7 CCL5 CCL3
24 cytomegalovirus infection 9.7 CCL5 CCL3
25 tropical spastic paraparesis 9.7 CCL5 CCL3
26 dengue disease 9.7 CCL5 CCL3
27 extrinsic allergic alveolitis 9.7 CCL5 CCL3
28 proteasome-associated autoinflammatory syndrome 1 9.6 CCL5 CCL3
29 severe acute respiratory syndrome 9.6 CCL5 CCL3
30 bronchiolitis 9.6 CCL5 CCL3
31 schistosomiasis 9.5 CCL5 CCL3
32 whiplash 9.5 CCR5 CCL5 CCL3
33 orofacial granulomatosis 9.5 CCR5 CCL5 CCL3
34 periapical granuloma 9.5 CCR5 CCL5 CCL3
35 pulmonary sarcoidosis 9.5 CCR5 CCL5 CCL3
36 neuritis 9.5 CCR5 CCL5 CCL3
37 primary bacterial infectious disease 9.5 CCR5 CCL5 CCL3
38 chagas disease 9.5 CCR5 CCL5 CCL3
39 human immunodeficiency virus infectious disease 9.5 CCR5 CCL5 CCL3
40 encephalitis 9.5 CCR5 CCL5 CCL3
41 trypanosomiasis 9.5 CCL5 CCL3
42 viral infectious disease 9.5 CCR5 CCL5 CCL3
43 pulmonary disease, chronic obstructive 9.5 CCR5 CCL5 CCL3
44 human immunodeficiency virus type 1 9.4 CCR5 CCL5 CCL3
45 lung disease 9.4 CCR5 CCL5 CCL3
46 aspergillosis 9.4 CCL5 CCL3
47 relapsing-remitting multiple sclerosis 9.2 CCL5 CCL3
48 sarcoidosis 1 9.2 CXCR6 CCR5 CCL5 CCL3
49 immune deficiency disease 9.1 CXCR6 CCR5 CCL5 CCL3

Graphical network of the top 20 diseases related to Diabetes Mellitus, Insulin-Dependent, 22:



Diseases related to Diabetes Mellitus, Insulin-Dependent, 22

Symptoms & Phenotypes for Diabetes Mellitus, Insulin-Dependent, 22

Clinical features from OMIM:

612522

Drugs & Therapeutics for Diabetes Mellitus, Insulin-Dependent, 22

Search Clinical Trials , NIH Clinical Center for Diabetes Mellitus, Insulin-Dependent, 22

Genetic Tests for Diabetes Mellitus, Insulin-Dependent, 22

Genetic tests related to Diabetes Mellitus, Insulin-Dependent, 22:

# Genetic test Affiliating Genes
1 Diabetes Mellitus, Insulin-Dependent, 22 29 CCR5

Anatomical Context for Diabetes Mellitus, Insulin-Dependent, 22

MalaCards organs/tissues related to Diabetes Mellitus, Insulin-Dependent, 22:

40
Eye, Kidney, Heart, Small Intestine

Publications for Diabetes Mellitus, Insulin-Dependent, 22

Articles related to Diabetes Mellitus, Insulin-Dependent, 22:

# Title Authors PMID Year
1
Shared and distinct genetic variants in type 1 diabetes and celiac disease. 56
19073967 2008
2
Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. 56
8756719 1996
3
Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. 56
8751444 1996
4
Delayed small intestinal transit in patients with long-standing type 1 diabetes mellitus: investigation of the relationships with clinical features, gastric emptying, psychological distress, and nutritional parameters. 61
23126582 2013
5
[Fetuin A and matrix GLA protein in long standing type I diabetic patients without ischaemic heart disease]. 61
17642133 2006

Variations for Diabetes Mellitus, Insulin-Dependent, 22

Expression for Diabetes Mellitus, Insulin-Dependent, 22

Search GEO for disease gene expression data for Diabetes Mellitus, Insulin-Dependent, 22.

Pathways for Diabetes Mellitus, Insulin-Dependent, 22

Pathways related to Diabetes Mellitus, Insulin-Dependent, 22 according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.85 CXCR6 CCR5 CCL5 CCL3
2
Show member pathways
12.82 CXCR6 CCR5 CCL5 CCL3
3
Show member pathways
12.62 CXCR6 CCR5 CCL5 CCL3
4
Show member pathways
12.45 CCR5 CCL5 CCL3
5
Show member pathways
12.21 CXCR6 CCR5 CCL5 CCL3
6
Show member pathways
11.55 CCR5 CCL3
7 11.43 CCL5 CCL3
8 11.34 CXCR6 CCL3
9
Show member pathways
11.26 CXCR6 CCR5 CCL5 CCL3
10 11.12 CCL5 CCL3
11 10.82 CCR5 CCL5 CCL3

GO Terms for Diabetes Mellitus, Insulin-Dependent, 22

Cellular components related to Diabetes Mellitus, Insulin-Dependent, 22 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell GO:0005623 8.92 CXCR6 CCR5 CCL5 CCL3

Biological processes related to Diabetes Mellitus, Insulin-Dependent, 22 according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.99 GPR1 CXCR6 CCR5 CCL5 CCL3
2 G protein-coupled receptor signaling pathway GO:0007186 9.83 GPR1 CXCR6 CCR5 CCL5 CCL3
3 immune response GO:0006955 9.8 CXCR6 CCR5 CCL5 CCL3
4 cytokine-mediated signaling pathway GO:0019221 9.79 CCR5 CCL5 CCL3
5 MAPK cascade GO:0000165 9.77 CCR5 CCL5 CCL3
6 cell-cell signaling GO:0007267 9.76 CCR5 CCL5 CCL3
7 calcium ion transport GO:0006816 9.71 CCR5 CCL5 CCL3
8 inflammatory response GO:0006954 9.71 CXCR6 CCR5 CCL5 CCL3
9 cellular calcium ion homeostasis GO:0006874 9.66 CCL5 CCL3
10 cellular response to interferon-gamma GO:0071346 9.65 CCL5 CCL3
11 response to toxic substance GO:0009636 9.65 CCL5 CCL3
12 cellular response to interleukin-1 GO:0071347 9.65 CCL5 CCL3
13 neutrophil chemotaxis GO:0030593 9.64 CCL5 CCL3
14 cellular response to organic cyclic compound GO:0071407 9.64 CCL5 CCL3
15 positive chemotaxis GO:0050918 9.63 CCL5 CCL3
16 monocyte chemotaxis GO:0002548 9.63 CCL5 CCL3
17 protein kinase B signaling GO:0043491 9.62 CCL5 CCL3
18 lymphocyte chemotaxis GO:0048247 9.62 CCL5 CCL3
19 lipopolysaccharide-mediated signaling pathway GO:0031663 9.61 CCL5 CCL3
20 positive regulation of calcium ion transport GO:0051928 9.58 CCL5 CCL3
21 eosinophil chemotaxis GO:0048245 9.57 CCL5 CCL3
22 dendritic cell chemotaxis GO:0002407 9.56 CCR5 CCL5
23 macrophage chemotaxis GO:0048246 9.55 CCL5 CCL3
24 negative regulation by host of viral transcription GO:0043922 9.52 CCL5 CCL3
25 response to cholesterol GO:0070723 9.51 CCR5 CCL3
26 signaling GO:0023052 9.48 CCR5 CCL3
27 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808 9.46 CCR5 CCL3
28 chemotaxis GO:0006935 9.46 CXCR6 CCR5 CCL5 CCL3
29 calcium-mediated signaling GO:0019722 9.43 CXCR6 CCR5 CCL3
30 positive regulation of natural killer cell chemotaxis GO:2000503 9.37 CCL5 CCL3
31 negative regulation of macrophage apoptotic process GO:2000110 9.32 CCR5 CCL5
32 cell chemotaxis GO:0060326 9.26 CXCR6 CCR5 CCL5 CCL3
33 chemokine-mediated signaling pathway GO:0070098 8.92 CXCR6 CCR5 CCL5 CCL3

Molecular functions related to Diabetes Mellitus, Insulin-Dependent, 22 according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.83 EIF2B1 CCR5 CCL5 CCL3
2 chemokine activity GO:0008009 9.51 CCL5 CCL3
3 coreceptor activity GO:0015026 9.49 CXCR6 CCR5
4 chemoattractant activity GO:0042056 9.48 CCL5 CCL3
5 CCR chemokine receptor binding GO:0048020 9.46 CCL5 CCL3
6 chemokine binding GO:0019956 9.43 CXCR6 CCR5
7 phosphatidylinositol phospholipase C activity GO:0004435 9.4 CCR5 CCL5
8 C-C chemokine binding GO:0019957 9.37 CXCR6 CCR5
9 C-C chemokine receptor activity GO:0016493 9.32 CXCR6 CCR5
10 chemokine receptor activity GO:0004950 9.26 CXCR6 CCR5
11 CCR5 chemokine receptor binding GO:0031730 9.16 CCL5 CCL3
12 phospholipase activator activity GO:0016004 8.96 CCL5 CCL3
13 CCR1 chemokine receptor binding GO:0031726 8.62 CCL5 CCL3

Sources for Diabetes Mellitus, Insulin-Dependent, 22

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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