IDDM22
MCID: DBT032
MIFTS: 28

Diabetes Mellitus, Insulin-Dependent, 22 (IDDM22)

Categories: Endocrine diseases, Genetic diseases, Metabolic diseases, Rare diseases

Aliases & Classifications for Diabetes Mellitus, Insulin-Dependent, 22

MalaCards integrated aliases for Diabetes Mellitus, Insulin-Dependent, 22:

Name: Diabetes Mellitus, Insulin-Dependent, 22 56 73 29 13 71
Iddm22 56 12 73
Type 1 Diabetes Mellitus 22 12 15
Diabetes Mellitus, Insulin-Dependent, Type 22 39
Insulin-Dependent Diabetes Mellitus 22 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0110759
OMIM 56 612522
MeSH 43 D003922
ICD10 32 E10
MedGen 41 C2675864
UMLS 71 C2675864

Summaries for Diabetes Mellitus, Insulin-Dependent, 22

UniProtKB/Swiss-Prot : 73 Diabetes mellitus, insulin-dependent, 22: A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.

MalaCards based summary : Diabetes Mellitus, Insulin-Dependent, 22, also known as iddm22, is related to whiplash and alexithymia. An important gene associated with Diabetes Mellitus, Insulin-Dependent, 22 is CCR5 (C-C Motif Chemokine Receptor 5 (Gene/Pseudogene)), and among its related pathways/superpathways are Integrin Pathway and Akt Signaling. Affiliated tissues include eye, kidney and heart.

Disease Ontology : 12 A type 1 diabetes mellitus that has material basis in mutation of the CCR5 gene on chromosome 3p21.31.

More information from OMIM: 612522

Related Diseases for Diabetes Mellitus, Insulin-Dependent, 22

Graphical network of the top 20 diseases related to Diabetes Mellitus, Insulin-Dependent, 22:



Diseases related to Diabetes Mellitus, Insulin-Dependent, 22

Symptoms & Phenotypes for Diabetes Mellitus, Insulin-Dependent, 22

Clinical features from OMIM:

612522

Drugs & Therapeutics for Diabetes Mellitus, Insulin-Dependent, 22

Search Clinical Trials , NIH Clinical Center for Diabetes Mellitus, Insulin-Dependent, 22

Genetic Tests for Diabetes Mellitus, Insulin-Dependent, 22

Genetic tests related to Diabetes Mellitus, Insulin-Dependent, 22:

# Genetic test Affiliating Genes
1 Diabetes Mellitus, Insulin-Dependent, 22 29 CCR5

Anatomical Context for Diabetes Mellitus, Insulin-Dependent, 22

MalaCards organs/tissues related to Diabetes Mellitus, Insulin-Dependent, 22:

40
Eye, Kidney, Heart, Small Intestine

Publications for Diabetes Mellitus, Insulin-Dependent, 22

Articles related to Diabetes Mellitus, Insulin-Dependent, 22:

# Title Authors PMID Year
1
Shared and distinct genetic variants in type 1 diabetes and celiac disease. 56
19073967 2008
2
Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. 56
8756719 1996
3
Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. 56
8751444 1996
4
Delayed small intestinal transit in patients with long-standing type 1 diabetes mellitus: investigation of the relationships with clinical features, gastric emptying, psychological distress, and nutritional parameters. 61
23126582 2013
5
[Fetuin A and matrix GLA protein in long standing type I diabetic patients without ischaemic heart disease]. 61
17642133 2006

Variations for Diabetes Mellitus, Insulin-Dependent, 22

Expression for Diabetes Mellitus, Insulin-Dependent, 22

Search GEO for disease gene expression data for Diabetes Mellitus, Insulin-Dependent, 22.

Pathways for Diabetes Mellitus, Insulin-Dependent, 22

Pathways related to Diabetes Mellitus, Insulin-Dependent, 22 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.81 GNAO1 CCR5 CCL4L1 CCL4
2
Show member pathways
12.77 GNAO1 CCR5 CCL4L1 CCL4
3
Show member pathways
12.39 CCR5 CCL4L1 CCL4
4
Show member pathways
12.05 GNAO1 CCR5 CCL4L1 CCL4
5
Show member pathways
11.67 CCR5 CCL4L1 CCL4
6 11.49 CCL4L1 CCL4
7 11.31 CCL4L1 CCL4
8 10.95 CCR5 CCL4
9
Show member pathways
10.85 CCR5 CCL4L1 CCL4
10 10.51 GNAO1 CCL4L1 CCL4

GO Terms for Diabetes Mellitus, Insulin-Dependent, 22

Biological processes related to Diabetes Mellitus, Insulin-Dependent, 22 according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.8 GPR1 GNAO1 CCR5 CCL4
2 inflammatory response GO:0006954 9.54 CCR5 CCL4L1 CCL4
3 positive regulation of GTPase activity GO:0043547 9.5 GNAO1 CCL4L1 CCL4
4 cellular response to tumor necrosis factor GO:0071356 9.48 CCL4L1 CCL4
5 cellular response to interferon-gamma GO:0071346 9.46 CCL4L1 CCL4
6 neutrophil chemotaxis GO:0030593 9.43 CCL4L1 CCL4
7 cellular response to interleukin-1 GO:0071347 9.4 CCL4L1 CCL4
8 G protein-coupled receptor signaling pathway GO:0007186 9.35 GPR1 GNAO1 CCR5 CCL4L1 CCL4
9 monocyte chemotaxis GO:0002548 9.26 CCL4L1 CCL4
10 lymphocyte chemotaxis GO:0048247 9.16 CCL4L1 CCL4
11 chemokine-mediated signaling pathway GO:0070098 8.8 CCR5 CCL4L1 CCL4

Molecular functions related to Diabetes Mellitus, Insulin-Dependent, 22 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 8.96 CCL4L1 CCL4
2 CCR chemokine receptor binding GO:0048020 8.62 CCL4L1 CCL4

Sources for Diabetes Mellitus, Insulin-Dependent, 22

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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