IDDM23
MCID: DBT053
MIFTS: 31

Diabetes Mellitus, Insulin-Dependent, 23 (IDDM23)

Categories: Genetic diseases, Metabolic diseases

Aliases & Classifications for Diabetes Mellitus, Insulin-Dependent, 23

MalaCards integrated aliases for Diabetes Mellitus, Insulin-Dependent, 23:

Name: Diabetes Mellitus, Insulin-Dependent, 23 56 13 71
Type 1 Diabetes Mellitus 23 12 15
Iddm23 56 12
Insulin-Dependent Diabetes Mellitus 23 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0110760
OMIM 56 612622
ICD10 32 E10
MedGen 41 C2675472
UMLS 71 C2675472

Summaries for Diabetes Mellitus, Insulin-Dependent, 23

Disease Ontology : 12 A type 1 diabetes mellitus that has material basis in mutation of the locus at chromosome 4q27.

MalaCards based summary : Diabetes Mellitus, Insulin-Dependent, 23, also known as type 1 diabetes mellitus 23, is related to diabetes mellitus, type i and scleredema adultorum. An important gene associated with Diabetes Mellitus, Insulin-Dependent, 23 is IDDM23 (Diabetes Mellitus, Insulin-Dependent, 23), and among its related pathways/superpathways are Allograft rejection and T cell receptor signaling pathway. Affiliated tissues include bone and kidney, and related phenotypes are cellular and hematopoietic system

More information from OMIM: 612622

Related Diseases for Diabetes Mellitus, Insulin-Dependent, 23

Diseases in the Diabetes Mellitus, Insulin-Dependent, 20 family:

Diabetes Mellitus, Insulin-Dependent, 2 Diabetes Mellitus, Insulin-Dependent, 3
Diabetes Mellitus, Insulin-Dependent, 4 Diabetes Mellitus, Insulin-Dependent, 5
Diabetes Mellitus, Insulin-Dependent, 7 Diabetes Mellitus, Insulin-Dependent, 8
Diabetes Mellitus, Insulin-Dependent, 11 Diabetes Mellitus, Insulin-Dependent, 13
Diabetes Mellitus, Insulin-Dependent, 12 Diabetes Mellitus, Insulin-Dependent, 15
Diabetes Mellitus, Insulin-Dependent, 6 Diabetes Mellitus, Insulin-Dependent, 10
Diabetes Mellitus, Insulin-Dependent, 17 Diabetes Mellitus, Insulin-Dependent, 18
Diabetes Mellitus, Insulin-Dependent, 19 Diabetes Mellitus, Insulin-Dependent, 21
Diabetes Mellitus, Insulin-Dependent, 22 Diabetes Mellitus, Insulin-Dependent, 23
Diabetes Mellitus, Insulin-Dependent, 24

Diseases related to Diabetes Mellitus, Insulin-Dependent, 23 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 317)
# Related Disease Score Top Affiliating Genes
1 diabetes mellitus, type i 29.1 TNF SELL INS IDDM23 CD8A CD4
2 scleredema adultorum 10.1 INS CD8A
3 cork-handlers' disease 10.1 CD8A CD4
4 ventilation pneumonitis 10.0 CD8A CD4
5 diffuse infiltrative lymphocytosis syndrome 10.0 CD8A CD4
6 autoimmune lymphoproliferative syndrome, type iia 10.0 CD8A CD4
7 early yaws 10.0 CD8A CD4
8 bird fancier's lung 10.0 CD8A CD4
9 parapsoriasis 10.0 CD8A CD4
10 norwegian scabies 10.0 CD8A CD4
11 variola major 10.0 CD8A CD4
12 follicular mucinosis 10.0 CD8A CD4
13 viral exanthem 10.0 CD8A CD4
14 tertiary syphilis 10.0 CD8A CD4
15 spongiotic dermatitis 10.0 CD8A CD4
16 acute retinal necrosis syndrome 10.0 CD8A CD4
17 invasive malignant thymoma 10.0 CD8A CD4
18 acute interstitial pneumonia 10.0 CD8A CD4
19 west nile encephalitis 10.0 CD8A CD4
20 oral hairy leukoplakia 10.0 CD8A CD4
21 secondary syphilis 10.0 CD8A CD4
22 glanders 10.0 CD8A CD4
23 parotid disease 10.0 CD8A CD4
24 nickel allergic contact dermatitis 10.0 CD8A CD4
25 west nile fever 10.0 CD8A CD4
26 esophageal candidiasis 10.0 CD8A CD4
27 marasmus 10.0 INS CD4
28 myeloid and lymphoid neoplasms associated with fgfr1 abnormalities 10.0 CD8A CD4
29 cardiomyopathy, familial hypertrophic, 9 10.0 CD8A CD4
30 adenoid hypertrophy 10.0 CD8A CD4
31 dacryoadenitis 10.0 CD8A CD4
32 combat disorder 10.0 CD8A CD4
33 xerophthalmia 10.0 CD8A CD4
34 kwashiorkor 10.0 INS CD4
35 monkeypox 10.0 CD8A CD4
36 retinitis pigmentosa 46 10.0 CD8A CD4
37 borst-jadassohn intraepidermal carcinoma 10.0 CD8A CD4
38 immunodeficiency with hyper-igm, type 3 10.0 CD8A CD4
39 ebola hemorrhagic fever 10.0 CD8A CD4
40 mucormycosis 10.0 INS CD4
41 bell's palsy 10.0 CD8A CD4
42 alopecia universalis congenita 10.0 CD8A CD4
43 congenital toxoplasmosis 10.0 CD8A CD4
44 anus cancer 10.0 CD8A CD4
45 giardiasis 10.0 CD8A CD4
46 autoimmune glomerulonephritis 10.0 CD8A CD4
47 autoimmune disease of urogenital tract 10.0 CD8A CD4
48 diabetic angiopathy 10.0 INS AOC3
49 lassa fever 10.0 CD8A CD4
50 t-cell adult acute lymphocytic leukemia 10.0 CD8A CD4

Graphical network of the top 20 diseases related to Diabetes Mellitus, Insulin-Dependent, 23:



Diseases related to Diabetes Mellitus, Insulin-Dependent, 23

Symptoms & Phenotypes for Diabetes Mellitus, Insulin-Dependent, 23

Clinical features from OMIM:

612622

MGI Mouse Phenotypes related to Diabetes Mellitus, Insulin-Dependent, 23:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.73 AOC3 CD4 CD8A INS SELL TNF
2 hematopoietic system MP:0005397 9.63 AOC3 CD4 CD8A INS SELL TNF
3 immune system MP:0005387 9.43 AOC3 CD4 CD8A INS SELL TNF
4 integument MP:0010771 9.02 CD4 CD8A INS SELL TNF

Drugs & Therapeutics for Diabetes Mellitus, Insulin-Dependent, 23

Search Clinical Trials , NIH Clinical Center for Diabetes Mellitus, Insulin-Dependent, 23

Genetic Tests for Diabetes Mellitus, Insulin-Dependent, 23

Anatomical Context for Diabetes Mellitus, Insulin-Dependent, 23

MalaCards organs/tissues related to Diabetes Mellitus, Insulin-Dependent, 23:

40
Bone, Kidney

Publications for Diabetes Mellitus, Insulin-Dependent, 23

Articles related to Diabetes Mellitus, Insulin-Dependent, 23:

# Title Authors PMID Year
1
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci. 56
18978792 2008
2
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. 56
17554260 2007
3
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. 56
17554300 2007
4
Genetics of Kidneys in Diabetes (GoKinD) study: a genetics collection available for identifying genetic susceptibility factors for diabetic nephropathy in type 1 diabetes. 56
16775037 2006
5
Age and sex based genetic locus heterogeneity in type 1 diabetes. 56
10699054 2000
6
A genome-wide search for human type 1 diabetes susceptibility genes. 56
8072542 1994
7
Health-related quality of life in type 1 diabetic patients and influence of peripheral nerve involvement. 61
11731877 2001
8
The effect of pramlintide (amylin analogue) treatment on bone metabolism and bone density in patients with type 1 diabetes mellitus. 61
10494873 1999

Variations for Diabetes Mellitus, Insulin-Dependent, 23

Expression for Diabetes Mellitus, Insulin-Dependent, 23

Search GEO for disease gene expression data for Diabetes Mellitus, Insulin-Dependent, 23.

Pathways for Diabetes Mellitus, Insulin-Dependent, 23

GO Terms for Diabetes Mellitus, Insulin-Dependent, 23

Cellular components related to Diabetes Mellitus, Insulin-Dependent, 23 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.26 TNF SELL CD4 AOC3
2 external side of plasma membrane GO:0009897 8.92 TNF SELL CD8A CD4

Biological processes related to Diabetes Mellitus, Insulin-Dependent, 23 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cognition GO:0050890 9.4 TNF INS
2 T cell activation GO:0042110 9.37 CD8A CD4
3 positive regulation of cytokine secretion GO:0050715 9.32 TNF INS
4 positive regulation of nitric-oxide synthase activity GO:0051000 9.26 TNF INS
5 leukocyte tethering or rolling GO:0050901 9.16 TNF SELL
6 negative regulation of lipid catabolic process GO:0050995 8.96 TNF INS
7 regulation of protein secretion GO:0050708 8.62 TNF INS

Molecular functions related to Diabetes Mellitus, Insulin-Dependent, 23 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 coreceptor activity GO:0015026 8.96 CD8A CD4
2 protease binding GO:0002020 8.8 TNF SELL INS

Sources for Diabetes Mellitus, Insulin-Dependent, 23

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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