IDDM23
MCID: DBT053
MIFTS: 32

Diabetes Mellitus, Insulin-Dependent, 23 (IDDM23)

Categories: Endocrine diseases, Genetic diseases, Metabolic diseases, Rare diseases

Aliases & Classifications for Diabetes Mellitus, Insulin-Dependent, 23

MalaCards integrated aliases for Diabetes Mellitus, Insulin-Dependent, 23:

Name: Diabetes Mellitus, Insulin-Dependent, 23 56 13 71
Type 1 Diabetes Mellitus 23 12 15
Iddm23 56 12
Insulin-Dependent Diabetes Mellitus 23 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0110760
OMIM 56 612622
ICD10 32 E10
MedGen 41 C2675472
UMLS 71 C2675472

Summaries for Diabetes Mellitus, Insulin-Dependent, 23

Disease Ontology : 12 A type 1 diabetes mellitus that has material basis in mutation of the locus at chromosome 4q27.

MalaCards based summary : Diabetes Mellitus, Insulin-Dependent, 23, also known as type 1 diabetes mellitus 23, is related to diabetes mellitus, insulin-dependent and granulocytopenia. An important gene associated with Diabetes Mellitus, Insulin-Dependent, 23 is IDDM23 (Diabetes Mellitus, Insulin-Dependent, 23), and among its related pathways/superpathways are Allograft rejection and T cell receptor signaling pathway. Affiliated tissues include bone and kidney, and related phenotypes are cellular and hematopoietic system

More information from OMIM: 612622

Related Diseases for Diabetes Mellitus, Insulin-Dependent, 23

Diseases in the Diabetes Mellitus, Insulin-Dependent family:

Diabetes Mellitus, Insulin-Dependent, 2 Diabetes Mellitus, Insulin-Dependent, 3
Diabetes Mellitus, Insulin-Dependent, 4 Diabetes Mellitus, Insulin-Dependent, 5
Diabetes Mellitus, Insulin-Dependent, 7 Diabetes Mellitus, Insulin-Dependent, 8
Diabetes Mellitus, Insulin-Dependent, 11 Diabetes Mellitus, Insulin-Dependent, 13
Diabetes Mellitus, Insulin-Dependent, 12 Diabetes Mellitus, Insulin-Dependent, 15
Diabetes Mellitus, Insulin-Dependent, 6 Diabetes Mellitus, Insulin-Dependent, 10
Diabetes Mellitus, Insulin-Dependent, 17 Diabetes Mellitus, Insulin-Dependent, 18
Diabetes Mellitus, Insulin-Dependent, 19 Diabetes Mellitus, Insulin-Dependent, 20
Diabetes Mellitus, Insulin-Dependent, 21 Diabetes Mellitus, Insulin-Dependent, 22
Diabetes Mellitus, Insulin-Dependent, 23 Diabetes Mellitus, Insulin-Dependent, 24

Diseases related to Diabetes Mellitus, Insulin-Dependent, 23 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 292)
# Related Disease Score Top Affiliating Genes
1 diabetes mellitus, insulin-dependent 29.3 TNF SELL INS IDDM23 CD8A CD4
2 granulocytopenia 10.1 TNF SELL
3 scleredema adultorum 10.1 INS CD8A
4 arthus reaction 10.1 TNF SELL
5 listeria meningitis 10.0 TNF CD8A
6 non-alcoholic steatohepatitis 10.0 TNF INS
7 necrobiosis lipoidica 10.0 TNF INS
8 diabetic angiopathy 10.0 INS AOC3
9 alveolar echinococcosis 10.0 TNF CD8A
10 echinococcosis 10.0 TNF CD8A
11 decubitus ulcer 10.0 TNF INS
12 swine influenza 10.0 TNF CD8A
13 macular retinal edema 10.0 TNF INS
14 dermatitis herpetiformis 9.9 TNF SELL
15 diabetic polyneuropathy 9.9 TNF INS
16 chronic ulcer of skin 9.9 TNF INS
17 cork-handlers' disease 9.9 CD8A CD4
18 inflammatory bowel disease 28 9.9 CD4 AOC3
19 syphilitic meningitis 9.9 CD8A CD4
20 ventilation pneumonitis 9.9 CD8A CD4
21 diffuse infiltrative lymphocytosis syndrome 9.9 CD8A CD4
22 autoimmune lymphoproliferative syndrome, type iia 9.9 CD8A CD4
23 chromosome 14q11-q22 deletion syndrome 9.9 CD8A CD4
24 bird fancier's lung 9.9 CD8A CD4
25 early yaws 9.9 CD8A CD4
26 parapsoriasis 9.9 CD8A CD4
27 sebaceous gland disease 9.9 TNF INS
28 norwegian scabies 9.9 CD8A CD4
29 metal allergy 9.9 CD8A CD4
30 variola major 9.9 CD8A CD4
31 follicular mucinosis 9.9 CD8A CD4
32 tertiary syphilis 9.9 CD8A CD4
33 syphilis 9.9 CD8A CD4
34 spongiotic dermatitis 9.9 CD8A CD4
35 acute retinal necrosis syndrome 9.9 CD8A CD4
36 granulomatous hepatitis 9.9 CD8A CD4
37 nickel allergic contact dermatitis 9.9 CD8A CD4
38 west nile encephalitis 9.9 CD8A CD4
39 cd3zeta deficiency 9.9 CD8A CD4
40 immunodeficiency 18 9.9 CD8A CD4
41 cerebritis 9.9 CD8A CD4
42 acute interstitial pneumonia 9.9 CD8A CD4
43 parotid disease 9.9 CD8A CD4
44 apnea, obstructive sleep 9.9 TNF INS
45 superficial basal cell carcinoma 9.9 CD8A CD4
46 secondary syphilis 9.9 CD8A CD4
47 oral hairy leukoplakia 9.9 CD8A CD4
48 marasmus 9.9 INS CD4
49 esophageal candidiasis 9.9 CD8A CD4
50 myeloid and lymphoid neoplasms associated with fgfr1 abnormalities 9.9 CD8A CD4

Graphical network of the top 20 diseases related to Diabetes Mellitus, Insulin-Dependent, 23:



Diseases related to Diabetes Mellitus, Insulin-Dependent, 23

Symptoms & Phenotypes for Diabetes Mellitus, Insulin-Dependent, 23

Clinical features from OMIM:

612622

MGI Mouse Phenotypes related to Diabetes Mellitus, Insulin-Dependent, 23:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.73 AOC3 CD4 CD8A INS SELL TNF
2 hematopoietic system MP:0005397 9.63 AOC3 CD4 CD8A INS SELL TNF
3 immune system MP:0005387 9.43 AOC3 CD4 CD8A INS SELL TNF
4 integument MP:0010771 9.02 CD4 CD8A INS SELL TNF

Drugs & Therapeutics for Diabetes Mellitus, Insulin-Dependent, 23

Search Clinical Trials , NIH Clinical Center for Diabetes Mellitus, Insulin-Dependent, 23

Genetic Tests for Diabetes Mellitus, Insulin-Dependent, 23

Anatomical Context for Diabetes Mellitus, Insulin-Dependent, 23

MalaCards organs/tissues related to Diabetes Mellitus, Insulin-Dependent, 23:

40
Bone, Kidney

Publications for Diabetes Mellitus, Insulin-Dependent, 23

Articles related to Diabetes Mellitus, Insulin-Dependent, 23:

# Title Authors PMID Year
1
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci. 56
18978792 2008
2
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. 56
17554260 2007
3
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. 56
17554300 2007
4
Genetics of Kidneys in Diabetes (GoKinD) study: a genetics collection available for identifying genetic susceptibility factors for diabetic nephropathy in type 1 diabetes. 56
16775037 2006
5
Age and sex based genetic locus heterogeneity in type 1 diabetes. 56
10699054 2000
6
A genome-wide search for human type 1 diabetes susceptibility genes. 56
8072542 1994
7
Health-related quality of life in type 1 diabetic patients and influence of peripheral nerve involvement. 61
11731877 2001
8
The effect of pramlintide (amylin analogue) treatment on bone metabolism and bone density in patients with type 1 diabetes mellitus. 61
10494873 1999

Variations for Diabetes Mellitus, Insulin-Dependent, 23

Expression for Diabetes Mellitus, Insulin-Dependent, 23

Search GEO for disease gene expression data for Diabetes Mellitus, Insulin-Dependent, 23.

Pathways for Diabetes Mellitus, Insulin-Dependent, 23

GO Terms for Diabetes Mellitus, Insulin-Dependent, 23

Cellular components related to Diabetes Mellitus, Insulin-Dependent, 23 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 TNF SELL CD8A CD4

Biological processes related to Diabetes Mellitus, Insulin-Dependent, 23 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 T cell activation GO:0042110 9.4 CD8A CD4
2 cognition GO:0050890 9.37 TNF INS
3 positive regulation of cytokine secretion GO:0050715 9.32 TNF INS
4 positive regulation of nitric-oxide synthase activity GO:0051000 9.26 TNF INS
5 leukocyte tethering or rolling GO:0050901 9.16 TNF SELL
6 negative regulation of lipid catabolic process GO:0050995 8.96 TNF INS
7 regulation of protein secretion GO:0050708 8.62 TNF INS

Molecular functions related to Diabetes Mellitus, Insulin-Dependent, 23 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 coreceptor activity GO:0015026 8.96 CD8A CD4
2 protease binding GO:0002020 8.8 TNF SELL INS

Sources for Diabetes Mellitus, Insulin-Dependent, 23

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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