IDDM24
MCID: DBT054
MIFTS: 25

Diabetes Mellitus, Insulin-Dependent, 24 (IDDM24)

Categories: Genetic diseases, Metabolic diseases

Aliases & Classifications for Diabetes Mellitus, Insulin-Dependent, 24

MalaCards integrated aliases for Diabetes Mellitus, Insulin-Dependent, 24:

Name: Diabetes Mellitus, Insulin-Dependent, 24 56 13 71
Type 1 Diabetes Mellitus 24 12 15
Iddm24 56 12
Insulin-Dependent Diabetes Mellitus 24 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0110761
OMIM 56 613006
ICD10 32 E10
MedGen 41 C2751697
UMLS 71 C2751697

Summaries for Diabetes Mellitus, Insulin-Dependent, 24

Disease Ontology : 12 A type 1 diabetes mellitus that has material basis in mutation of the locus at chromosome 10q23.31.

MalaCards based summary : Diabetes Mellitus, Insulin-Dependent, 24, also known as type 1 diabetes mellitus 24, is related to diabetes mellitus, type i and alpha-thalassemia/mental retardation syndrome, chromosome 16-related. An important gene associated with Diabetes Mellitus, Insulin-Dependent, 24 is IDDM24 (Diabetes Mellitus, Insulin-Dependent, 24), and among its related pathways/superpathways are TRAF Pathway and NF-kappaB Signaling. Related phenotype is hematopoietic system.

More information from OMIM: 613006

Related Diseases for Diabetes Mellitus, Insulin-Dependent, 24

Diseases in the Diabetes Mellitus, Insulin-Dependent, 20 family:

Diabetes Mellitus, Insulin-Dependent, 2 Diabetes Mellitus, Insulin-Dependent, 3
Diabetes Mellitus, Insulin-Dependent, 4 Diabetes Mellitus, Insulin-Dependent, 5
Diabetes Mellitus, Insulin-Dependent, 7 Diabetes Mellitus, Insulin-Dependent, 8
Diabetes Mellitus, Insulin-Dependent, 11 Diabetes Mellitus, Insulin-Dependent, 13
Diabetes Mellitus, Insulin-Dependent, 12 Diabetes Mellitus, Insulin-Dependent, 15
Diabetes Mellitus, Insulin-Dependent, 6 Diabetes Mellitus, Insulin-Dependent, 10
Diabetes Mellitus, Insulin-Dependent, 17 Diabetes Mellitus, Insulin-Dependent, 18
Diabetes Mellitus, Insulin-Dependent, 19 Diabetes Mellitus, Insulin-Dependent, 21
Diabetes Mellitus, Insulin-Dependent, 22 Diabetes Mellitus, Insulin-Dependent, 23
Diabetes Mellitus, Insulin-Dependent, 24

Diseases related to Diabetes Mellitus, Insulin-Dependent, 24 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
# Related Disease Score Top Affiliating Genes
1 diabetes mellitus, type i 29.5 TLR3 LTA IFIH1 IDDM24 HBA2 HBA1
2 alpha-thalassemia/mental retardation syndrome, chromosome 16-related 10.3 HBA2 HBA1
3 glutathione peroxidase deficiency 10.3 HBA2 HBA1
4 methemoglobinemia, beta-globin type 10.3 HBA2 HBA1
5 erythrocytosis, familial, 7 10.3 HBA2 HBA1
6 alpha thalassemia-intellectual disability syndrome type 1 10.2 HBA2 HBA1
7 hypoglycemic coma 10.2 HBA2 HBA1
8 hydrops fetalis, nonimmune 10.2 HBA2 HBA1
9 type 1 diabetes mellitus 2 10.2 GIMAP5 G6PC2
10 erythrocytosis, familial, 8 10.2 HBA2 HBA1
11 diabetes mellitus, noninsulin-dependent 10.1
12 heinz body anemias 10.1 HBA2 HBA1
13 hypochromic microcytic anemia 10.1 HBA2 HBA1
14 neuropathy, hereditary sensory and autonomic, type iib 9.9 WNK1 DACT1
15 herpangina 9.2 TLR3 IFIH1
16 malaria 8.5 TLR3 LTA IFIH1 HBA2 HBA1
17 diabetes mellitus, insulin-dependent, 20 8.1 WNK1 UBD TLR3 MAS1L LTA IFIH1

Graphical network of the top 20 diseases related to Diabetes Mellitus, Insulin-Dependent, 24:



Diseases related to Diabetes Mellitus, Insulin-Dependent, 24

Symptoms & Phenotypes for Diabetes Mellitus, Insulin-Dependent, 24

Clinical features from OMIM:

613006

MGI Mouse Phenotypes related to Diabetes Mellitus, Insulin-Dependent, 24:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.28 CASP2 G6PC2 HBA2 IFIH1 LTA NLRP10

Drugs & Therapeutics for Diabetes Mellitus, Insulin-Dependent, 24

Search Clinical Trials , NIH Clinical Center for Diabetes Mellitus, Insulin-Dependent, 24

Genetic Tests for Diabetes Mellitus, Insulin-Dependent, 24

Anatomical Context for Diabetes Mellitus, Insulin-Dependent, 24

Publications for Diabetes Mellitus, Insulin-Dependent, 24

Articles related to Diabetes Mellitus, Insulin-Dependent, 24:

# Title Authors PMID Year
1
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. 56
19430480 2009
2
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci. 56
18978792 2008
3
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. 56
17554300 2007
4
A novel susceptibility locus on rat chromosome 8 affects spontaneous but not experimentally induced type 1 diabetes. 61
17389329 2007

Variations for Diabetes Mellitus, Insulin-Dependent, 24

Expression for Diabetes Mellitus, Insulin-Dependent, 24

Search GEO for disease gene expression data for Diabetes Mellitus, Insulin-Dependent, 24.

Pathways for Diabetes Mellitus, Insulin-Dependent, 24

Pathways related to Diabetes Mellitus, Insulin-Dependent, 24 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.79 UBD TLR3 LTA CASP2
2 11.44 UBD TLR3 IFIH1 GIMAP5
3 10.82 HBA2 HBA1
4
Show member pathways
10.7 HBA2 HBA1

GO Terms for Diabetes Mellitus, Insulin-Dependent, 24

Cellular components related to Diabetes Mellitus, Insulin-Dependent, 24 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endocytic vesicle lumen GO:0071682 9.16 HBA2 HBA1
2 hemoglobin complex GO:0005833 8.96 HBA2 HBA1
3 haptoglobin-hemoglobin complex GO:0031838 8.62 HBA2 HBA1

Biological processes related to Diabetes Mellitus, Insulin-Dependent, 24 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.56 UBD TLR3 LTA CASP2
2 hydrogen peroxide catabolic process GO:0042744 9.37 HBA2 HBA1
3 positive regulation of interferon-beta production GO:0032728 9.32 TLR3 IFIH1
4 cellular response to exogenous dsRNA GO:0071360 9.16 TLR3 IFIH1
5 oxygen transport GO:0015671 8.96 HBA2 HBA1
6 detection of virus GO:0009597 8.62 TLR3 IFIH1

Molecular functions related to Diabetes Mellitus, Insulin-Dependent, 24 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peroxidase activity GO:0004601 9.32 HBA2 HBA1
2 oxygen binding GO:0019825 9.26 HBA2 HBA1
3 oxygen carrier activity GO:0005344 9.16 HBA2 HBA1
4 organic acid binding GO:0043177 8.96 HBA2 HBA1
5 haptoglobin binding GO:0031720 8.62 HBA2 HBA1

Sources for Diabetes Mellitus, Insulin-Dependent, 24

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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