Diabetes Mellitus, Insulin-Dependent, 24 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Diabetes Mellitus, Insulin-Dependent, 24

MalaCards integrated aliases for Diabetes Mellitus, Insulin-Dependent, 24:

Name: Diabetes Mellitus, Insulin-Dependent, 24 ⁵⁷ ¹³ ⁷³

Type 1 Diabetes Mellitus 24 ¹² ¹⁵

Iddm24 ⁵⁷ ¹²

Insulin-Dependent Diabetes Mellitus 24 ¹²

Classifications:

MalaCards categories:
Global: Metabolic diseases Genetic diseases Rare diseases
Anatomical: Endocrine diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Endocrine, nutritional and metabolic diseases

Diabetes mellitus

Insulin-dependent diabetes mellitus

External Ids:

OMIM ⁵⁷ 613006

Disease Ontology ¹² DOID:0110761

ICD10 ³³ E10

MedGen ⁴² C2751697

UMLS ⁷³ C2751697

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Summaries for Diabetes Mellitus, Insulin-Dependent, 24

Disease Ontology : ¹² A type 1 diabetes mellitus that has material basis in mutation of the locus at chromosome 10q23.31.

MalaCards based summary : Diabetes Mellitus, Insulin-Dependent, 24, also known as type 1 diabetes mellitus 24, is related to diabetes mellitus, insulin-dependent and alpha-thalassemia/mental retardation syndrome, chromosome 16-related. An important gene associated with Diabetes Mellitus, Insulin-Dependent, 24 is IDDM24 (Diabetes Mellitus, Insulin-Dependent, 24), and among its related pathways/superpathways are Binding and Uptake of Ligands by Scavenger Receptors and Malaria. Related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Description from OMIM: 613006

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Related Diseases for Diabetes Mellitus, Insulin-Dependent, 24

Diseases in the Diabetes Mellitus, Insulin-Dependent family:

Diabetes Mellitus, Insulin-Dependent, 2	Diabetes Mellitus, Insulin-Dependent, 3
Diabetes Mellitus, Insulin-Dependent, 4	Diabetes Mellitus, Insulin-Dependent, 5
Diabetes Mellitus, Insulin-Dependent, 7	Diabetes Mellitus, Insulin-Dependent, 8
Diabetes Mellitus, Insulin-Dependent, 11	Diabetes Mellitus, Insulin-Dependent, 13
Diabetes Mellitus, Insulin-Dependent, 12	Diabetes Mellitus, Insulin-Dependent, 15
Diabetes Mellitus, Insulin-Dependent, 6	Diabetes Mellitus, Insulin-Dependent, 10
Diabetes Mellitus, Insulin-Dependent, 17	Diabetes Mellitus, Insulin-Dependent, 18
Diabetes Mellitus, Insulin-Dependent, 19	Diabetes Mellitus, Insulin-Dependent, 20
Diabetes Mellitus, Insulin-Dependent, 21	Diabetes Mellitus, Insulin-Dependent, 22
Diabetes Mellitus, Insulin-Dependent, 23	Diabetes Mellitus, Insulin-Dependent, 24

Diseases related to Diabetes Mellitus, Insulin-Dependent, 24 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 24)

#	Related Disease	Score	Top Affiliating Genes
1	diabetes mellitus, insulin-dependent	11.2
2	alpha-thalassemia/mental retardation syndrome, chromosome 16-related	9.9	HBA1 HBA2
3	alpha-thalassemia	9.9	HBA1 HBA2
4	thalassemia	9.9	HBA1 HBA2
5	methemoglobinemia, beta-globin type	9.9	HBA1 HBA2
6	hydrops fetalis	9.9	HBA1 HBA2
7	hydrops fetalis, nonimmune	9.9	HBA1 HBA2
8	glutathione peroxidase deficiency	9.9	HBA1 HBA2
9	immune hydrops fetalis	9.9	HBA1 HBA2
10	hypoglycemic coma	9.9	HBA1 HBA2
11	heinz body anemias	9.9	HBA1 HBA2
12	erythrocytosis, familial, 7	9.9	HBA1 HBA2
13	type 1 diabetes mellitus 7	9.9	HBA1 HBA2
14	type 1 diabetes mellitus 11	9.8	HBA1 HBA2
15	immature cataract	9.8	HBA1 HBA2
16	alpha thalassemia-intellectual disability syndrome type 1	9.8	HBA1 HBA2
17	hemoglobin h disease	9.8	HBA1 HBA2
18	hemoglobinopathy	9.8	HBA1 HBA2
19	microcytic anemia	9.8	HBA1 HBA2
20	retinal vascular disease	9.8	HBA1 HBA2
21	sickle cell anemia	9.8	HBA1 HBA2
22	glucose metabolism disease	9.8	HBA1 HBA2
23	beta-thalassemia	9.7	HBA1 HBA2
24	hemolytic anemia	9.6	HBA1 HBA2

Graphical network of the top 20 diseases related to Diabetes Mellitus, Insulin-Dependent, 24:

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Symptoms & Phenotypes for Diabetes Mellitus, Insulin-Dependent, 24

Clinical features from OMIM:

613006

GenomeRNAi Phenotypes related to Diabetes Mellitus, Insulin-Dependent, 24 according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased shRNA abundance (Z-score < -2)	GR00366-A-181	9.91	HBA1 HBA2
2	Decreased shRNA abundance (Z-score < -2)	GR00366-A-48	9.91	HBA1 HBA2
3	Decreased shRNA abundance (Z-score < -2)	GR00366-A-72	9.91	HBA1 HBA2
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-105	9.7	HBA1 HBA2
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-113	9.7	HBA1 HBA2
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-140	9.7	HBA1 HBA2
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-205	9.7	HBA1 HBA2

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Drugs & Therapeutics for Diabetes Mellitus, Insulin-Dependent, 24

Search Clinical Trials , NIH Clinical Center for Diabetes Mellitus, Insulin-Dependent, 24

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Genetic Tests for Diabetes Mellitus, Insulin-Dependent, 24

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Anatomical Context for Diabetes Mellitus, Insulin-Dependent, 24

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Publications for Diabetes Mellitus, Insulin-Dependent, 24

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Genes for Diabetes Mellitus, Insulin-Dependent, 24

Genes related to Diabetes Mellitus, Insulin-Dependent, 24 (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	IDDM24	Diabetes Mellitus, Insulin-Dependent, 24	Genetic Locus	58.8	Susceptibility factor ⁵⁷ GeneCards inferred via : Gene name (show sections)
2	HBA2	Hemoglobin Subunit Alpha 2	Protein Coding	15	DISEASES inferred ¹⁵
3	HBA1	Hemoglobin Subunit Alpha 1	Protein Coding	14.32	DISEASES inferred ¹⁵
4	OGA	O-GlcNAcase	Protein Coding	5.03	DISEASES inferred ¹⁵

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Variations for Diabetes Mellitus, Insulin-Dependent, 24

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Expression for Diabetes Mellitus, Insulin-Dependent, 24

Search GEO for disease gene expression data for Diabetes Mellitus, Insulin-Dependent, 24.

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Pathways for Diabetes Mellitus, Insulin-Dependent, 24

Pathways related to Diabetes Mellitus, Insulin-Dependent, 24 according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Binding and Uptake of Ligands by Scavenger Receptors ⁶⁶ Show member pathways Scavenging by Class A Receptors ⁶⁶ Scavenging by Class B Receptors ⁶⁶ Scavenging by Class F Receptors ⁶⁶ Scavenging by Class H Receptors ⁶⁶ Scavenging of heme from plasma ⁶⁶	11.27	HBA1 HBA2
2	Malaria ³⁷	10.85	HBA1 HBA2
3	African trypanosomiasis ³⁷	10.5	HBA1 HBA2
4	Erythrocytes take up carbon dioxide and release oxygen ⁶⁶ Show member pathways Erythrocytes take up oxygen and release carbon dioxide ⁶⁶ O2/CO2 exchange in erythrocytes ⁶⁶	10.17	HBA1 HBA2

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GO Terms for Diabetes Mellitus, Insulin-Dependent, 24

Cellular components related to Diabetes Mellitus, Insulin-Dependent, 24 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	blood microparticle	GO:0072562	9.32	HBA1 HBA2
2	cytosolic small ribosomal subunit	GO:0022627	9.26	HBA1 HBA2
3	endocytic vesicle lumen	GO:0071682	9.16	HBA1 HBA2
4	hemoglobin complex	GO:0005833	8.96	HBA1 HBA2
5	haptoglobin-hemoglobin complex	GO:0031838	8.62	HBA1 HBA2

Biological processes related to Diabetes Mellitus, Insulin-Dependent, 24 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	receptor-mediated endocytosis	GO:0006898	9.43	HBA1 HBA2
2	cellular oxidant detoxification	GO:0098869	9.4	HBA1 HBA2
3	protein heterooligomerization	GO:0051291	9.37	HBA1 HBA2
4	response to hydrogen peroxide	GO:0042542	9.32	HBA1 HBA2
5	positive regulation of cell death	GO:0010942	9.26	HBA1 HBA2
6	bicarbonate transport	GO:0015701	9.16	HBA1 HBA2
7	hydrogen peroxide catabolic process	GO:0042744	8.96	HBA1 HBA2
8	oxygen transport	GO:0015671	8.62	HBA1 HBA2

Molecular functions related to Diabetes Mellitus, Insulin-Dependent, 24 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	heme binding	GO:0020037	9.4	HBA1 HBA2
2	iron ion binding	GO:0005506	9.37	HBA1 HBA2
3	oxygen binding	GO:0019825	9.32	HBA1 HBA2
4	peroxidase activity	GO:0004601	9.26	HBA1 HBA2
5	oxygen carrier activity	GO:0005344	9.16	HBA1 HBA2
6	organic acid binding	GO:0043177	8.96	HBA1 HBA2
7	haptoglobin binding	GO:0031720	8.62	HBA1 HBA2

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