MCID: DBT054
MIFTS: 27

Diabetes Mellitus, Insulin-Dependent, 24

Categories: Metabolic diseases, Genetic diseases, Rare diseases, Endocrine diseases

Aliases & Classifications for Diabetes Mellitus, Insulin-Dependent, 24

MalaCards integrated aliases for Diabetes Mellitus, Insulin-Dependent, 24:

Name: Diabetes Mellitus, Insulin-Dependent, 24 57 13 73
Type 1 Diabetes Mellitus 24 12 15
Iddm24 57 12
Insulin-Dependent Diabetes Mellitus 24 12

Classifications:



External Ids:

OMIM 57 613006
Disease Ontology 12 DOID:0110761
ICD10 33 E10
MedGen 42 C2751697
UMLS 73 C2751697

Summaries for Diabetes Mellitus, Insulin-Dependent, 24

Disease Ontology : 12 A type 1 diabetes mellitus that has material basis in mutation of the locus at chromosome 10q23.31.

MalaCards based summary : Diabetes Mellitus, Insulin-Dependent, 24, also known as type 1 diabetes mellitus 24, is related to diabetes mellitus, insulin-dependent and alpha-thalassemia/mental retardation syndrome, chromosome 16-related. An important gene associated with Diabetes Mellitus, Insulin-Dependent, 24 is IDDM24 (Diabetes Mellitus, Insulin-Dependent, 24), and among its related pathways/superpathways are Binding and Uptake of Ligands by Scavenger Receptors and Malaria. Related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Description from OMIM: 613006

Related Diseases for Diabetes Mellitus, Insulin-Dependent, 24

Diseases in the Diabetes Mellitus, Insulin-Dependent family:

Diabetes Mellitus, Insulin-Dependent, 2 Diabetes Mellitus, Insulin-Dependent, 3
Diabetes Mellitus, Insulin-Dependent, 4 Diabetes Mellitus, Insulin-Dependent, 5
Diabetes Mellitus, Insulin-Dependent, 7 Diabetes Mellitus, Insulin-Dependent, 8
Diabetes Mellitus, Insulin-Dependent, 11 Diabetes Mellitus, Insulin-Dependent, 13
Diabetes Mellitus, Insulin-Dependent, 12 Diabetes Mellitus, Insulin-Dependent, 15
Diabetes Mellitus, Insulin-Dependent, 6 Diabetes Mellitus, Insulin-Dependent, 10
Diabetes Mellitus, Insulin-Dependent, 17 Diabetes Mellitus, Insulin-Dependent, 18
Diabetes Mellitus, Insulin-Dependent, 19 Diabetes Mellitus, Insulin-Dependent, 20
Diabetes Mellitus, Insulin-Dependent, 21 Diabetes Mellitus, Insulin-Dependent, 22
Diabetes Mellitus, Insulin-Dependent, 23 Diabetes Mellitus, Insulin-Dependent, 24

Diseases related to Diabetes Mellitus, Insulin-Dependent, 24 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 21)
# Related Disease Score Top Affiliating Genes
1 diabetes mellitus, insulin-dependent 11.1
2 alpha-thalassemia/mental retardation syndrome, chromosome 16-related 9.6 HBA1 HBA2
3 methemoglobinemia, beta-globin type 9.6 HBA1 HBA2
4 hydrops fetalis, nonimmune 9.6 HBA1 HBA2
5 glutathione peroxidase deficiency 9.6 HBA1 HBA2
6 hypoglycemic coma 9.6 HBA1 HBA2
7 heinz body anemias 9.6 HBA1 HBA2
8 type 1 diabetes mellitus 7 9.6 HBA1 HBA2
9 type 1 diabetes mellitus 11 9.6 HBA1 HBA2
10 immature cataract 9.5 HBA1 HBA2
11 hydrops fetalis 9.5 HBA1 HBA2
12 hemoglobin h disease 9.5 HBA1 HBA2
13 hemoglobinopathy 9.5 HBA1 HBA2
14 microcytic anemia 9.5 HBA1 HBA2
15 retinal vascular disease 9.4 HBA1 HBA2
16 sickle cell anemia 9.4 HBA1 HBA2
17 glucose metabolism disease 9.4 HBA1 HBA2
18 alpha-thalassemia 9.3 HBA1 HBA2
19 thalassemia 9.2 HBA1 HBA2
20 beta-thalassemia 9.1 HBA1 HBA2
21 hemolytic anemia 8.9 HBA1 HBA2

Graphical network of the top 20 diseases related to Diabetes Mellitus, Insulin-Dependent, 24:



Diseases related to Diabetes Mellitus, Insulin-Dependent, 24

Symptoms & Phenotypes for Diabetes Mellitus, Insulin-Dependent, 24

Clinical features from OMIM:

613006

GenomeRNAi Phenotypes related to Diabetes Mellitus, Insulin-Dependent, 24 according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.91 HBA1 HBA2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.91 HBA1 HBA2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.91 HBA1 HBA2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.7 HBA2 HBA1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.7 HBA1 HBA2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-140 9.7 HBA1 HBA2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-205 9.7 HBA2 HBA1

Drugs & Therapeutics for Diabetes Mellitus, Insulin-Dependent, 24

Search Clinical Trials , NIH Clinical Center for Diabetes Mellitus, Insulin-Dependent, 24

Genetic Tests for Diabetes Mellitus, Insulin-Dependent, 24

Anatomical Context for Diabetes Mellitus, Insulin-Dependent, 24

Publications for Diabetes Mellitus, Insulin-Dependent, 24

Variations for Diabetes Mellitus, Insulin-Dependent, 24

Expression for Diabetes Mellitus, Insulin-Dependent, 24

Search GEO for disease gene expression data for Diabetes Mellitus, Insulin-Dependent, 24.

Pathways for Diabetes Mellitus, Insulin-Dependent, 24

GO Terms for Diabetes Mellitus, Insulin-Dependent, 24

Cellular components related to Diabetes Mellitus, Insulin-Dependent, 24 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 9.32 HBA1 HBA2
2 cytosolic small ribosomal subunit GO:0022627 9.26 HBA1 HBA2
3 endocytic vesicle lumen GO:0071682 9.16 HBA1 HBA2
4 hemoglobin complex GO:0005833 8.96 HBA1 HBA2
5 haptoglobin-hemoglobin complex GO:0031838 8.62 HBA1 HBA2

Biological processes related to Diabetes Mellitus, Insulin-Dependent, 24 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor-mediated endocytosis GO:0006898 9.43 HBA1 HBA2
2 cellular oxidant detoxification GO:0098869 9.4 HBA1 HBA2
3 protein heterooligomerization GO:0051291 9.37 HBA1 HBA2
4 response to hydrogen peroxide GO:0042542 9.32 HBA1 HBA2
5 positive regulation of cell death GO:0010942 9.26 HBA1 HBA2
6 bicarbonate transport GO:0015701 9.16 HBA1 HBA2
7 hydrogen peroxide catabolic process GO:0042744 8.96 HBA1 HBA2
8 oxygen transport GO:0015671 8.62 HBA1 HBA2

Molecular functions related to Diabetes Mellitus, Insulin-Dependent, 24 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 iron ion binding GO:0005506 9.37 HBA1 HBA2
2 heme binding GO:0020037 9.32 HBA1 HBA2
3 oxygen binding GO:0019825 9.26 HBA1 HBA2
4 peroxidase activity GO:0004601 9.16 HBA1 HBA2
5 oxygen carrier activity GO:0005344 8.96 HBA1 HBA2
6 haptoglobin binding GO:0031720 8.62 HBA1 HBA2

Sources for Diabetes Mellitus, Insulin-Dependent, 24

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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