IDDM4
MCID: DBT056
MIFTS: 19

Diabetes Mellitus, Insulin-Dependent, 4 (IDDM4)

Categories: Endocrine diseases, Genetic diseases, Metabolic diseases, Rare diseases

Aliases & Classifications for Diabetes Mellitus, Insulin-Dependent, 4

MalaCards integrated aliases for Diabetes Mellitus, Insulin-Dependent, 4:

Name: Diabetes Mellitus, Insulin-Dependent, 4 57 13 72
Insulin-Dependent Diabetes Mellitus 4 57
Iddm4 57

Classifications:



External Ids:

OMIM 57 600319
MedGen 42 C1838261
UMLS 72 C1838261

Summaries for Diabetes Mellitus, Insulin-Dependent, 4

MalaCards based summary : Diabetes Mellitus, Insulin-Dependent, 4, also known as insulin-dependent diabetes mellitus 4, is related to type 1 diabetes mellitus 4 and diabetes mellitus, insulin-dependent. An important gene associated with Diabetes Mellitus, Insulin-Dependent, 4 is IDDM4 (Insulin Dependent Diabetes Mellitus 4). Affiliated tissues include bone, bone marrow and t cells.

More information from OMIM: 600319

Related Diseases for Diabetes Mellitus, Insulin-Dependent, 4

Diseases in the Diabetes Mellitus, Insulin-Dependent family:

Diabetes Mellitus, Insulin-Dependent, 2 Diabetes Mellitus, Insulin-Dependent, 3
Diabetes Mellitus, Insulin-Dependent, 4 Diabetes Mellitus, Insulin-Dependent, 5
Diabetes Mellitus, Insulin-Dependent, 7 Diabetes Mellitus, Insulin-Dependent, 8
Diabetes Mellitus, Insulin-Dependent, 11 Diabetes Mellitus, Insulin-Dependent, 13
Diabetes Mellitus, Insulin-Dependent, 12 Diabetes Mellitus, Insulin-Dependent, 15
Diabetes Mellitus, Insulin-Dependent, 6 Diabetes Mellitus, Insulin-Dependent, 10
Diabetes Mellitus, Insulin-Dependent, 17 Diabetes Mellitus, Insulin-Dependent, 18
Diabetes Mellitus, Insulin-Dependent, 19 Diabetes Mellitus, Insulin-Dependent, 20
Diabetes Mellitus, Insulin-Dependent, 21 Diabetes Mellitus, Insulin-Dependent, 22
Diabetes Mellitus, Insulin-Dependent, 23 Diabetes Mellitus, Insulin-Dependent, 24

Diseases related to Diabetes Mellitus, Insulin-Dependent, 4 via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 13, show less)
# Related Disease Score Top Affiliating Genes
1 type 1 diabetes mellitus 4 11.7
2 diabetes mellitus, insulin-dependent 11.6
3 diabetes mellitus, insulin-dependent, 2 10.4
4 diabetes mellitus, insulin-dependent, 3 10.4
5 diabetes mellitus, insulin-dependent, 5 10.4
6 diabetes mellitus, insulin-dependent, 8 10.3
7 lymphopenia 10.3
8 diabetes mellitus 10.3
9 diabetes mellitus, insulin-dependent, 7 10.1
10 diabetes mellitus, insulin-dependent, 17 10.1
11 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.1
12 diabetes mellitus, insulin-dependent, 20 10.1
13 type 1 diabetes mellitus 7 10.1

Graphical network of the top 20 diseases related to Diabetes Mellitus, Insulin-Dependent, 4:



Diseases related to Diabetes Mellitus, Insulin-Dependent, 4

Symptoms & Phenotypes for Diabetes Mellitus, Insulin-Dependent, 4

Clinical features from OMIM:

600319

Drugs & Therapeutics for Diabetes Mellitus, Insulin-Dependent, 4

Search Clinical Trials , NIH Clinical Center for Diabetes Mellitus, Insulin-Dependent, 4

Genetic Tests for Diabetes Mellitus, Insulin-Dependent, 4

Anatomical Context for Diabetes Mellitus, Insulin-Dependent, 4

MalaCards organs/tissues related to Diabetes Mellitus, Insulin-Dependent, 4:

41
Bone, Bone Marrow, T Cells

Publications for Diabetes Mellitus, Insulin-Dependent, 4

Articles related to Diabetes Mellitus, Insulin-Dependent, 4:

(showing 42, show less)
# Title Authors PMID Year
1
Age and sex based genetic locus heterogeneity in type 1 diabetes. 38 8
10699054 2000
2
Fine-mapping of the type 1 diabetes locus (IDDM4) on chromosome 11q and evaluation of two candidate genes (FADD and GALN) by affected sibpair and linkage-disequilibrium analyses. 38 8
10982176 2000
3
Cloning of a novel member of the low-density lipoprotein receptor family. 38 8
9714764 1998
4
Fine mapping of the diabetes-susceptibility locus, IDDM4, on chromosome 11q13. 38 8
9683605 1998
5
Two-locus maximum lod score analysis of a multifactorial trait: joint consideration of IDDM2 and IDDM4 with IDDM1 in type 1 diabetes. 38 8
7573054 1995
6
A genome-wide search for human type 1 diabetes susceptibility genes. 38 8
8072542 1994
7
Analysis of the CD3 gene region and type 1 diabetes: application of fluorescence-based technology to linkage disequilibrium mapping. 8
7757067 1995
8
Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome 11q. 8
8072544 1994
9
High-resolution linkage mapping for susceptibility genes in human polygenic disease: insulin-dependent diabetes mellitus and chromosome 11q. 8
1990836 1991
10
Susceptibility to type I diabetes in women is associated with the CD3 epsilon locus on chromosome 11. 8
1671006 1991
11
Linkage strategies for genetically complex traits. I. Multilocus models. 8
2301392 1990
12
Diabetic mouse incorrectly typed. 8
3187535 1988
13
Three recessive loci required for insulin-dependent diabetes in nonobese diabetic mice. 8
2885918 1987
14
Ampligen: a potential toll-like 3 receptor adjuvant for immunotherapy of cancer. 38
19200817 2009
15
Analysis of the rat Iddm14 diabetes susceptibility locus in multiple rat strains: identification of a susceptibility haplotype in the Tcrb-V locus. 38
19205800 2009
16
PolyI:C induction of diabetes is controlled by Iddm4 in rats with a full regulatory T cell pool. 38
17911421 2007
17
Refinement of the Iddm4 diabetes susceptibility locus reveals TCRVbeta4 as a candidate gene. 38
17376830 2007
18
Aberrancies in the differentiation and maturation of dendritic cells from bone-marrow precursors are linked to various genes on chromosome 4 and other chromosomes of the BB-DP rat. 38
16023326 2005
19
The rat diabetes susceptibility locus Iddm4 and at least one additional gene are required for autoimmune diabetes induced by viral infection. 38
15793267 2005
20
Genetic variation in the multifunctional transcription factor Yy1 and type 1 diabetes mellitus in the BB rat. 38
15234341 2004
21
Rat models of type 1 diabetes: genetics, environment, and autoimmunity. 38
15229375 2004
22
Comparative mapping of rat Iddm4 to segments on HSA7 and MMU6. 38
14727142 2004
23
Linkage and association mapping of the LRP5 locus on chromosome 11q13 in type 1 diabetes. 38
12700977 2003
24
The iddm4 locus segregates with diabetes susceptibility in congenic WF.iddm4 rats. 38
12401717 2002
25
Preliminary studies on associations of IDDM3, IDDM4, IDDM5 and IDDM8 with IDDM in Chengdu population. 38
12901503 2001
26
Genes of SHR rats protect spontaneously diabetic BB/OK rats from diabetes: lessons from congenic BB.SHR rat strains. 38
11327715 2001
27
The sequence and gene characterization of a 400-kb candidate region for IDDM4 on chromosome 11q13. 38
11401438 2001
28
Evidence for a new Graves disease susceptibility locus at chromosome 18q21. 38
10762555 2000
29
Diabetes-prone and diabetes-resistant BB rats share a common major diabetes susceptibility locus, iddm4: additional evidence for a "universal autoimmunity locus" on rat chromosome 4. 38
10535446 1999
30
Genetic susceptibility factors in type 1 diabetes: linkage, disequilibrium and functional analyses. 38
9914216 1998
31
Quantitative trait loci for blood glucose confirm diabetes predisposing and protective genes, Iddm4 and Iddm5r, in the spontaneously diabetic BB/OK rat. 38
9858659 1998
32
Mapping of novel genes predisposing or protecting diabetes development in the BB/OK rat. 38
9571179 1998
33
A 3-Mb sequence-ready contig map encompassing the multiple disease gene cluster on chromosome 11q13.1-q13.3. 38
9405936 1997
34
Linkage analyses in type I diabetes mellitus using CASPAR, a software and statistical program for conditional analysis of polygenic diseases. 38
9239508 1997
35
Genetics of type 1 diabetes. 38
9296067 1997
36
Genomic structure and mapping of human FADD, an intracellular mediator of lymphocyte apoptosis. 38
8955195 1996
37
Confirmation of three susceptibility genes to insulin-dependent diabetes mellitus: IDDM4, IDDM5 and IDDM8. 38
8733139 1996
38
Linkage studies of NIDDM with 23 chromosome 11 markers in a sample of whites of northern European descent. 38
8593945 1996
39
Panning for gold: genome-wide scanning for linkage in type 1 diabetes. 38
8875250 1996
40
Affected-sib-pair mapping of a novel susceptibility gene to insulin-dependent diabetes mellitus (IDDM8) on chromosome 6q25-q27. 38
7573053 1995
41
Molecular genetics of diabetes mellitus. 38
7575335 1995
42
A locus on chromosome 15q26 (IDDM3) produces susceptibility to insulin-dependent diabetes mellitus. 38
7842018 1994

Variations for Diabetes Mellitus, Insulin-Dependent, 4

Expression for Diabetes Mellitus, Insulin-Dependent, 4

Search GEO for disease gene expression data for Diabetes Mellitus, Insulin-Dependent, 4.

Pathways for Diabetes Mellitus, Insulin-Dependent, 4

GO Terms for Diabetes Mellitus, Insulin-Dependent, 4

Sources for Diabetes Mellitus, Insulin-Dependent, 4

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64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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