IDDM5
MCID: DBT038
MIFTS: 23

Diabetes Mellitus, Insulin-Dependent, 5 (IDDM5)

Categories: Endocrine diseases, Genetic diseases, Metabolic diseases, Rare diseases

Aliases & Classifications for Diabetes Mellitus, Insulin-Dependent, 5

MalaCards integrated aliases for Diabetes Mellitus, Insulin-Dependent, 5:

Name: Diabetes Mellitus, Insulin-Dependent, 5 58 76 30 13 6 74
Iddm5 58 76
Diabetes Mellitus, Insulin-Dependent, Type 5 41
Insulin-Dependent Diabetes Mellitus 5 58

Classifications:



External Ids:

OMIM 58 600320
MeSH 45 D003922
MedGen 43 C1838260
UMLS 74 C1838260

Summaries for Diabetes Mellitus, Insulin-Dependent, 5

UniProtKB/Swiss-Prot : 76 Diabetes mellitus, insulin-dependent, 5: A form of diabetes mellitus, a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.

MalaCards based summary : Diabetes Mellitus, Insulin-Dependent, 5, also known as iddm5, is related to type 1 diabetes mellitus 5 and diabetes mellitus, insulin-dependent. An important gene associated with Diabetes Mellitus, Insulin-Dependent, 5 is SUMO4 (Small Ubiquitin Like Modifier 4). Affiliated tissues include kidney and eye.

Description from OMIM: 600320

Related Diseases for Diabetes Mellitus, Insulin-Dependent, 5

Graphical network of the top 20 diseases related to Diabetes Mellitus, Insulin-Dependent, 5:



Diseases related to Diabetes Mellitus, Insulin-Dependent, 5

Symptoms & Phenotypes for Diabetes Mellitus, Insulin-Dependent, 5

Clinical features from OMIM:

600320

Drugs & Therapeutics for Diabetes Mellitus, Insulin-Dependent, 5

Search Clinical Trials , NIH Clinical Center for Diabetes Mellitus, Insulin-Dependent, 5

Genetic Tests for Diabetes Mellitus, Insulin-Dependent, 5

Genetic tests related to Diabetes Mellitus, Insulin-Dependent, 5:

# Genetic test Affiliating Genes
1 Diabetes Mellitus, Insulin-Dependent, 5 30 SUMO4

Anatomical Context for Diabetes Mellitus, Insulin-Dependent, 5

MalaCards organs/tissues related to Diabetes Mellitus, Insulin-Dependent, 5:

42
Kidney, Eye

Publications for Diabetes Mellitus, Insulin-Dependent, 5

Articles related to Diabetes Mellitus, Insulin-Dependent, 5:

(show all 11)
# Title Authors Year
1
Analyses of multiple single-nucleotide polymorphisms in the SUMO4/IDDM5 region in affected sib-pair families with type I diabetes. ( 19956095 )
2009
2
Association of small ubiquitin-like modifier 4 (SUMO4) variant, located in IDDM5 locus, with type 2 diabetes in the Japanese population. ( 17374705 )
2007
3
Association of SUMO4, as a candidate gene for IDDM5, with susceptibility to type 1 diabetes in Asian populations. ( 17130530 )
2006
4
The type 1 diabetes susceptibility gene SUMO4 at IDDM5 is not associated with susceptibility to rheumatoid arthritis or juvenile idiopathic arthritis. ( 16159953 )
2005
5
Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes. ( 15678135 )
2005
6
Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes. ( 15678134 )
2005
7
Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes. ( 15678137 )
2005
8
A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription factors and is associated with susceptibility to type I diabetes mellitus. ( 15123604 )
2004
9
A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes. ( 15247916 )
2004
10
Preliminary studies on associations of IDDM3, IDDM4, IDDM5 and IDDM8 with IDDM in Chengdu population. ( 12901503 )
2001
11
Confirmation of three susceptibility genes to insulin-dependent diabetes mellitus: IDDM4, IDDM5 and IDDM8. ( 8733139 )
1996

Variations for Diabetes Mellitus, Insulin-Dependent, 5

ClinVar genetic disease variations for Diabetes Mellitus, Insulin-Dependent, 5:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 SUMO4 NM_001002255.1(SUMO4): c.163G> A (p.Val55Met) single nucleotide variant risk factor rs237025 GRCh37 Chromosome 6, 149721690: 149721690
2 SUMO4 NM_001002255.1(SUMO4): c.163G> A (p.Val55Met) single nucleotide variant risk factor rs237025 GRCh38 Chromosome 6, 149400554: 149400554

Expression for Diabetes Mellitus, Insulin-Dependent, 5

Search GEO for disease gene expression data for Diabetes Mellitus, Insulin-Dependent, 5.

Pathways for Diabetes Mellitus, Insulin-Dependent, 5

GO Terms for Diabetes Mellitus, Insulin-Dependent, 5

Sources for Diabetes Mellitus, Insulin-Dependent, 5

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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