Diabetes Mellitus, Insulin-Dependent, 5 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Diabetes Mellitus, Insulin-Dependent, 5

MalaCards integrated aliases for Diabetes Mellitus, Insulin-Dependent, 5:

Name: Diabetes Mellitus, Insulin-Dependent, 5 ⁵⁸ ⁷⁶ ³⁰ ¹³ ⁶ ⁷⁴

Iddm5 ⁵⁸ ⁷⁶

Diabetes Mellitus, Insulin-Dependent, Type 5 ⁴¹

Insulin-Dependent Diabetes Mellitus 5 ⁵⁸

Classifications:

MalaCards categories:
Global: Genetic diseases Metabolic diseases Rare diseases
Anatomical: Endocrine diseases

See all MalaCards categories (disease lists)

External Ids:

OMIM ⁵⁸ 600320

MeSH ⁴⁵ D003922

MedGen ⁴³ C1838260

UMLS ⁷⁴ C1838260

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Summaries for Diabetes Mellitus, Insulin-Dependent, 5

UniProtKB/Swiss-Prot : ⁷⁶ Diabetes mellitus, insulin-dependent, 5: A form of diabetes mellitus, a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.

MalaCards based summary : Diabetes Mellitus, Insulin-Dependent, 5, also known as iddm5, is related to type 1 diabetes mellitus 5 and diabetes mellitus, insulin-dependent. An important gene associated with Diabetes Mellitus, Insulin-Dependent, 5 is SUMO4 (Small Ubiquitin Like Modifier 4). Affiliated tissues include kidney and eye.

Description from OMIM: 600320

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Related Diseases for Diabetes Mellitus, Insulin-Dependent, 5

Diseases in the Diabetes Mellitus, Insulin-Dependent family:

Diabetes Mellitus, Insulin-Dependent, 2	Diabetes Mellitus, Insulin-Dependent, 3
Diabetes Mellitus, Insulin-Dependent, 4	Diabetes Mellitus, Insulin-Dependent, 5
Diabetes Mellitus, Insulin-Dependent, 7	Diabetes Mellitus, Insulin-Dependent, 8
Diabetes Mellitus, Insulin-Dependent, 11	Diabetes Mellitus, Insulin-Dependent, 13
Diabetes Mellitus, Insulin-Dependent, 12	Diabetes Mellitus, Insulin-Dependent, 15
Diabetes Mellitus, Insulin-Dependent, 6	Diabetes Mellitus, Insulin-Dependent, 10
Diabetes Mellitus, Insulin-Dependent, 17	Diabetes Mellitus, Insulin-Dependent, 18
Diabetes Mellitus, Insulin-Dependent, 19	Diabetes Mellitus, Insulin-Dependent, 20
Diabetes Mellitus, Insulin-Dependent, 21	Diabetes Mellitus, Insulin-Dependent, 22
Diabetes Mellitus, Insulin-Dependent, 23	Diabetes Mellitus, Insulin-Dependent, 24

Diseases related to Diabetes Mellitus, Insulin-Dependent, 5 via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	type 1 diabetes mellitus 5	31.6	SUMO4 TAB2
2	diabetes mellitus, insulin-dependent	29.5	SUMO4 TAB2
3	diabetes mellitus, insulin-dependent, 4	10.2
4	diabetes mellitus, insulin-dependent, 8	10.2
5	rheumatoid arthritis	10.0
6	diabetes mellitus, insulin-dependent, 3	10.0
7	arthritis	10.0
8	diabetes mellitus	10.0
9	juvenile rheumatoid arthritis	10.0

Graphical network of the top 20 diseases related to Diabetes Mellitus, Insulin-Dependent, 5:

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Symptoms & Phenotypes for Diabetes Mellitus, Insulin-Dependent, 5

Clinical features from OMIM:

600320

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Drugs & Therapeutics for Diabetes Mellitus, Insulin-Dependent, 5

Search Clinical Trials , NIH Clinical Center for Diabetes Mellitus, Insulin-Dependent, 5

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Genetic Tests for Diabetes Mellitus, Insulin-Dependent, 5

Genetic tests related to Diabetes Mellitus, Insulin-Dependent, 5:

#	Genetic test	Affiliating Genes
1	Diabetes Mellitus, Insulin-Dependent, 5 ³⁰	SUMO4

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Anatomical Context for Diabetes Mellitus, Insulin-Dependent, 5

MalaCards organs/tissues related to Diabetes Mellitus, Insulin-Dependent, 5:

⁴²

Kidney, Eye

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Publications for Diabetes Mellitus, Insulin-Dependent, 5

Articles related to Diabetes Mellitus, Insulin-Dependent, 5:

(show all 11)

#	Title	Authors	Year
1	Analyses of multiple single-nucleotide polymorphisms in the SUMO4/IDDM5 region in affected sib-pair families with type I diabetes. ( 19956095 )	Podolsky R...Type I Diabetes Genetics Consortium	2009
2	Association of small ubiquitin-like modifier 4 (SUMO4) variant, located in IDDM5 locus, with type 2 diabetes in the Japanese population. ( 17374705 )	Noso S...Ikegami H	2007
3	Association of SUMO4, as a candidate gene for IDDM5, with susceptibility to type 1 diabetes in Asian populations. ( 17130530 )	Noso S...Ogihara T	2006
4	The type 1 diabetes susceptibility gene SUMO4 at IDDM5 is not associated with susceptibility to rheumatoid arthritis or juvenile idiopathic arthritis. ( 16159953 )	Gibbons LJ...Hinks A	2005
5	Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes. ( 15678135 )	Qu H...Polychronakos C	2005
6	Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes. ( 15678134 )	Smyth DJ...Todd JA	2005
7	Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes. ( 15678137 )	Park Y...Kim D	2005
8	A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription factors and is associated with susceptibility to type I diabetes mellitus. ( 15123604 )	Bohren KM...Owerbach D	2004
9	A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes. ( 15247916 )	Guo D...Wang CY	2004
10	Preliminary studies on associations of IDDM3, IDDM4, IDDM5 and IDDM8 with IDDM in Chengdu population. ( 12901503 )	Zhoucun A...Xiao C	2001
11	Confirmation of three susceptibility genes to insulin-dependent diabetes mellitus: IDDM4, IDDM5 and IDDM8. ( 8733139 )	Luo DF...She JX	1996

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Genes for Diabetes Mellitus, Insulin-Dependent, 5

Genes related to Diabetes Mellitus, Insulin-Dependent, 5 (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	SUMO4	Small Ubiquitin Like Modifier 4	Protein Coding	702.93	Molecular basis known ⁵⁸ Genetic Tests ³⁰ Susceptibility factor ⁵⁸ Risk factor ⁶ GeneCards inferred via : Disorders Variants (show sections)
2	TAB2	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 2	Protein Coding	18.03	GeneCards inferred via : Variants (show sections)

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Variations for Diabetes Mellitus, Insulin-Dependent, 5

ClinVar genetic disease variations for Diabetes Mellitus, Insulin-Dependent, 5:

⁶

#	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1	SUMO4	NM_001002255.1(SUMO4): c.163G> A (p.Val55Met)	single nucleotide variant	risk factor	rs237025	GRCh37	Chromosome 6, 149721690: 149721690
2	SUMO4	NM_001002255.1(SUMO4): c.163G> A (p.Val55Met)	single nucleotide variant	risk factor	rs237025	GRCh38	Chromosome 6, 149400554: 149400554

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Expression for Diabetes Mellitus, Insulin-Dependent, 5

Search GEO for disease gene expression data for Diabetes Mellitus, Insulin-Dependent, 5.

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Pathways for Diabetes Mellitus, Insulin-Dependent, 5

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GO Terms for Diabetes Mellitus, Insulin-Dependent, 5

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Sources for Diabetes Mellitus, Insulin-Dependent, 5

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⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia

Diabetes Mellitus, Insulin-Dependent, 5 (IDDM5)

Aliases & Classifications for Diabetes Mellitus, Insulin-Dependent, 5

MalaCards integrated aliases for Diabetes Mellitus, Insulin-Dependent, 5:

Classifications:

External Ids:

Summaries for Diabetes Mellitus, Insulin-Dependent, 5

Related Diseases for Diabetes Mellitus, Insulin-Dependent, 5

Diseases in the Diabetes Mellitus, Insulin-Dependent family:

Diseases related to Diabetes Mellitus, Insulin-Dependent, 5 via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Diabetes Mellitus, Insulin-Dependent, 5:

Symptoms & Phenotypes for Diabetes Mellitus, Insulin-Dependent, 5

Clinical features from OMIM:

Drugs & Therapeutics for Diabetes Mellitus, Insulin-Dependent, 5

Genetic Tests for Diabetes Mellitus, Insulin-Dependent, 5

Genetic tests related to Diabetes Mellitus, Insulin-Dependent, 5:

Anatomical Context for Diabetes Mellitus, Insulin-Dependent, 5

MalaCards organs/tissues related to Diabetes Mellitus, Insulin-Dependent, 5:

Publications for Diabetes Mellitus, Insulin-Dependent, 5

Articles related to Diabetes Mellitus, Insulin-Dependent, 5:

Genes for Diabetes Mellitus, Insulin-Dependent, 5

Genes related to Diabetes Mellitus, Insulin-Dependent, 5 (1 elite genes):

Variations for Diabetes Mellitus, Insulin-Dependent, 5

ClinVar genetic disease variations for Diabetes Mellitus, Insulin-Dependent, 5:

Expression for Diabetes Mellitus, Insulin-Dependent, 5

Pathways for Diabetes Mellitus, Insulin-Dependent, 5

GO Terms for Diabetes Mellitus, Insulin-Dependent, 5

Sources for Diabetes Mellitus, Insulin-Dependent, 5