MCID: DBT008
MIFTS: 47

Diabetic Angiopathy

Categories: Cardiovascular diseases

Aliases & Classifications for Diabetic Angiopathy

MalaCards integrated aliases for Diabetic Angiopathy:

Name: Diabetic Angiopathy 12 73 15 17
Diabetic Angiopathies 54 44 70
Diabetic Peripheral Angiopathy 12 70
Diabetic Vascular Disorder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11713
ICD9CM 34 250.7
MeSH 44 D003925
NCIt 50 C35610
SNOMED-CT 67 127014009
UMLS 70 C0011871 C0011875

Summaries for Diabetic Angiopathy

Disease Ontology : 12 A peripheral vascular disease that is characterized by narrowing of the arteries as a complication arising from chronic diabetes.

MalaCards based summary : Diabetic Angiopathy, also known as diabetic angiopathies, is related to microvascular complications of diabetes 3 and microvascular complications of diabetes 5. An important gene associated with Diabetic Angiopathy is AGER (Advanced Glycosylation End-Product Specific Receptor), and among its related pathways/superpathways are PEDF Induced Signaling and Toll-like Receptor Signaling Pathway. The drugs Bemiparin and Dalteparin have been mentioned in the context of this disorder. Affiliated tissues include endothelial, kidney and heart, and related phenotypes are Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) and cellular

Wikipedia : 73 Diabetic angiopathy is a form of angiopathy associated with diabetic complications. While not exclusive,... more...

Related Diseases for Diabetic Angiopathy

Diseases related to Diabetic Angiopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 171)
# Related Disease Score Top Affiliating Genes
1 microvascular complications of diabetes 3 30.6 INS BMP6 AGER
2 microvascular complications of diabetes 5 29.9 SOD2 NOS3 NOS2 INS AOC3 AGER
3 type 1 diabetes mellitus 29.8 SOD2 NOS2 INS CCL2 AOC3
4 impotence 29.8 NOS3 NOS2 INS EDN1
5 hyperglycemia 29.6 SOD2 SELE NOS3 NOS2 INS AGER
6 peripheral vascular disease 29.6 VWF THBD SELE NOS2 MTHFR CCL2
7 limb ischemia 29.5 VWF SELE NOS3 EDN1 CCL2
8 vasculitis 29.5 VWF THBD SELE CCL2
9 retinal vascular disease 29.5 NOS3 MTHFR INS FN1 CCL2
10 thrombosis 29.4 VWF THBD SELE MTHFR
11 arteriosclerosis 29.0 THBD SELE NOS3 INS EDN1 CCL2
12 atherosclerosis susceptibility 28.4 VWF THBD SELE NOS3 MTHFR INS
13 kidney disease 27.8 TNFRSF11B THBD NOS3 MTHFR INS EDN1
14 vascular disease 27.6 VWF TNFRSF11B THBD SELE NOS3 NOS2
15 hypertension, essential 26.9 VWF THBD SOD2 SELE NOS3 NOS2
16 diabetes mellitus 26.4 VWF THBD SOD2 SELE NOS3 NOS2
17 premature aging 10.3 SOD2 PDGFRB
18 cellular leiomyoma 10.3 CCL2 BMP6
19 scleroderma, familial progressive 10.2 EDN1 BMP6
20 microvascular complications of diabetes 4 10.2
21 microvascular complications of diabetes 6 10.2
22 microvascular complications of diabetes 7 10.2
23 platelet membrane fluidity 10.2 NOS3 NOS2
24 transient cerebral ischemia 10.2 SOD2 MTHFR CCL2
25 unilateral absence of a pulmonary artery 10.2 VWF THBD
26 hemifacial spasm 10.2 NOS3 MTHFR
27 generalized atherosclerosis 10.2 VWF INS
28 type 1 diabetes mellitus 23 10.2 INS AOC3
29 arteritic anterior ischemic optic neuropathy 10.2 NOS3 MTHFR
30 retinal vascular occlusion 10.2 MTHFR EDN1 CCL2
31 neuropathy 10.2
32 nephrosclerosis 10.2 MTHFR INS CCL2
33 thrombotic microangiopathy 10.2 VWF THBD
34 squamous blepharitis 10.2 SELE NOS2
35 retinal vein occlusion 10.2 MTHFR EDN1 CCL2
36 background diabetic retinopathy 10.1 INS EDN1 AGER
37 aging 10.1 SOD2 PDGFRB CAT
38 diabetic neuropathy 10.1 SOD2 INS AGER
39 ectodermal dysplasia 1, hypohidrotic, x-linked 10.1 VWF FN1 CCL2
40 leukostasis 10.1 SELE CCL2 AGER
41 extrinsic allergic alveolitis 10.1 SOD2 FN1 CCL2
42 pneumoconiosis 10.1 SOD2 FN1 CCL2
43 critical illness polyneuropathy 10.1 SELE INS
44 diabetic macular edema 10.1 SOD2 NOS3 CCL2
45 scleredema adultorum 10.1 INS FN1
46 thyroid angiosarcoma 10.1 VWF THBD
47 mesangial proliferative glomerulonephritis 10.1 FN1 EDN1 CCL2
48 gastroschisis 10.1 NOS3 MTHFR BMP6
49 dystrophinopathies 10.1 TNFSF10 NOS2
50 uremia 10.0 VWF TNFRSF11B NOS2 INS

Comorbidity relations with Diabetic Angiopathy via Phenotypic Disease Network (PDN):


Acute Cystitis Heart Disease
Hypertension, Essential Peripheral Vascular Disease

Graphical network of the top 20 diseases related to Diabetic Angiopathy:



Diseases related to Diabetic Angiopathy

Symptoms & Phenotypes for Diabetic Angiopathy

GenomeRNAi Phenotypes related to Diabetic Angiopathy according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 8.92 CAT INS PDGFRB TNFSF10

MGI Mouse Phenotypes related to Diabetic Angiopathy:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.39 ADM AGER AOC3 CAT FN1 IGFBP7
2 cardiovascular system MP:0005385 10.37 ADM AGER EDN1 FN1 INS NOS2
3 growth/size/body region MP:0005378 10.37 AGER BMP6 EDN1 FN1 IGFBP7 INS
4 homeostasis/metabolism MP:0005376 10.36 ADM AGER CAT EDN1 FN1 IGFBP7
5 hematopoietic system MP:0005397 10.32 ADM AGER AOC3 FN1 INS NOS2
6 immune system MP:0005387 10.31 ADM AGER AOC3 CCL2 FN1 INS
7 mortality/aging MP:0010768 10.2 ADM CAT EDN1 FN1 INS MTHFR
8 integument MP:0010771 10.14 ADM AGER FN1 IGFBP7 INS MTHFR
9 liver/biliary system MP:0005370 10.07 ADM FN1 INS MTHFR NOS2 NOS3
10 muscle MP:0005369 9.91 ADM AGER EDN1 FN1 INS NOS2
11 renal/urinary system MP:0005367 9.85 ADM AGER EDN1 INS NOS2 NOS3
12 reproductive system MP:0005389 9.7 ADM BMP6 FN1 IGFBP7 INS MTHFR
13 skeleton MP:0005390 9.36 AGER BMP6 EDN1 FN1 INS MTHFR

Drugs & Therapeutics for Diabetic Angiopathy

Drugs for Diabetic Angiopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Bemiparin Approved, Investigational Phase 2, Phase 3 91449-79-5
2
Dalteparin Approved Phase 2, Phase 3 9005-49-6
3
Heparin Approved, Investigational Phase 2, Phase 3 9005-49-6 772 9812414
4
Tinzaparin Approved Phase 2, Phase 3 9041-08-1, 9005-49-6 25244225
5 Fibrinolytic Agents Phase 2, Phase 3
6 Anticoagulants Phase 2, Phase 3
7 Heparin, Low-Molecular-Weight Phase 2, Phase 3
8 calcium heparin Phase 2, Phase 3
9
Ranibizumab Approved Phase 1, Phase 2 347396-82-1 459903
10
Lactitol Approved, Investigational Phase 1, Phase 2 585-86-4 157355
11 Anesthetics Phase 1, Phase 2
12 Angiogenesis Inhibitors Phase 1, Phase 2
13
Chlorhexidine Approved, Vet_approved Early Phase 1 55-56-1 9552079 2713
14
Povidone-iodine Approved Early Phase 1 25655-41-8
15
Iodine Approved, Investigational Early Phase 1 7553-56-2 807
16
Cadexomer iodine Experimental Early Phase 1 94820-09-4
17 Calcium, Dietary
18 Anti-Infective Agents, Local Early Phase 1
19 Anti-Bacterial Agents Early Phase 1
20 Chlorhexidine gluconate Early Phase 1
21 Anti-Infective Agents Early Phase 1
22 Disinfectants Early Phase 1
23 Dermatologic Agents Early Phase 1
24 insulin
25 Insulin, Globin Zinc
26
Calcium Nutraceutical 7440-70-2 271

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 Pegaptanib for Retinal Edema Secondary to Diabetic Vascular Disease(Preserve) Study Completed NCT01486238 Phase 4 Macugen® pegaptanib sodium
2 Triple-Blind Clinical Trial With Placebo Control to Evaluate the Efficacy of a Heparin of Low Molecular Weight (Bemiparin) for Treating Slow-Responding Ulcers in Diabetic Foot in Primary Care Terminated NCT00399425 Phase 2, Phase 3 bemiparin (low molecular weight heparin)
3 Effectiveness and Safety of Adipose-Derived Regenerative Cells for the Treatment of Critical Lower Limb Ischemia Unknown status NCT02864654 Phase 1, Phase 2
4 Intravitreal Ranibizumab Combined With Panretinal Photocoagulation in Patients With Treatment-Naive Proliferative Diabetic Retinopathy Completed NCT01746563 Phase 1, Phase 2 Ranibizumab
5 Study of the Mechanisms of the Arterial Calcification of the Members Subordinates in the Diabetes (Implication of the System RANK / RANKL / OSTEOPROTEGERINE) Unknown status NCT02431234
6 Patient Comfort and Antimicrobial Efficacy With Aqueous Chlorhexidine Versus Povidine-Iodine (Betadine) as Ocular Surface Disinfectant Prior to Intravitreal Injection Unknown status NCT03571100 Early Phase 1 Chlorhexidine;Povidine-Iodine
7 Does Managed Diabetes Care Decrease Cardiovascular Complications of Diabetes? Unknown status NCT00498147
8 Bone Metabolism and Endothelial Function in Patients With Type 2 Diabetes Mellitus and Charcot Foot - an Observational Comparative Study Completed NCT02435329
9 Prospective Randomised Comparing Trial Between an Infragenual Dilatation (ID), an ID With Stenting, an ID With Cutting Balloon and Laser Therapy Completed NCT00134277
10 Polymorphism Analysis of HLA-DRB1*04 Alleles in Patients With Type 2 Diabetic Macroangiopathy in Northeast Chinese Completed NCT02882945
11 Glycemic Variability Predicts Endothelial Dysfunction Completed NCT01083043
12 Arterial Stiffness and Complication Risk in Type 2 Diabetes Completed NCT02001532
13 Validating Imaging Biomarkers of Small Vessel Disease in Diabetic Individuals Using Advanced MRI Techniques. Recruiting NCT03754608
14 Effects of Flavanoids on Acute Peripheral Vascular Reactivity in Essential Hypertension, Type 2 Diabetes and Healthy Persons Recruiting NCT03722199
15 Additional Hyperbaric Oxygen After Lower Extremity Amputation - A Randomized Controlled Trial Recruiting NCT03594344
16 The Physiological Effects of Remote Ischemic Conditioning on the Healing of Diabetic Foot Ulcers Not yet recruiting NCT04567563
17 Effect of Vitrectomy on the Evolution of Refractory Diabetic Macular Edema: a Randomized Pragmatic Controlled Study Withdrawn NCT03603990

Search NIH Clinical Center for Diabetic Angiopathy

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Pentoxifylline

Cochrane evidence based reviews: diabetic angiopathies

Genetic Tests for Diabetic Angiopathy

Anatomical Context for Diabetic Angiopathy

MalaCards organs/tissues related to Diabetic Angiopathy:

40
Endothelial, Kidney, Heart, Smooth Muscle, Thyroid, Bone, Skin

Publications for Diabetic Angiopathy

Articles related to Diabetic Angiopathy:

(show top 50) (show all 717)
# Title Authors PMID Year
1
Short-chain aldehyde-derived ligands for RAGE and their actions on endothelial cells. 61 54
17462779 2007
2
Endothelins: regulators of extracellular matrix protein production in diabetes. 61 54
16741042 2006
3
Effects of irbesartan on intracellular antioxidant enzyme expression and activity in adolescents and young adults with early diabetic angiopathy. 54 61
15983321 2005
4
[Asymptomatic glycemic instability: how to measure it and which clinical applications? ]. 61 54
12746641 2003
5
Insulin-regulated increase of soluble vascular adhesion protein-1 in diabetes. 54 61
12466139 2002
6
Changes of endothelin in streptozotocin-induced diabetic rats: effects of an angiotensin converting enzyme inhibitor, enalapril maleate. 54 61
12379508 2002
7
Adrenomedullin and diabetes mellitus. 61 54
11747138 2001
8
[Adrenomedullin under physiologic and pathologic conditions]. 61 54
11419298 2001
9
Role of endothelin in diabetic vascular complications. 54 61
11444423 2001
10
Possible pathophysiological mechanisms for diabetic angiopathy in type 2 diabetes. 61 54
11004428 2000
11
Possible involvement of altered RGD sequence in reduced adhesive and spreading activities of advanced glycation end product-modified fibronectin to vascular smooth muscle cells. 61 54
11264870 2000
12
Abnormal markers of endothelial cell activation and oxidative stress in children, adolescents and young adults with type 1 diabetes with no clinical vascular disease. 61 54
10634966 1999
13
Determination of human serum semicarbazide-sensitive amine oxidase activity: a possible clinical marker of atherosclerosis. 54 61
10892891 1999
14
Urinary endothelin in adolescents and young adults with insulin-dependent diabetes mellitus: relation to urinary albumin, blood pressure, and other factors. 54 61
9826222 1998
15
Urinary free cortisol and its nyctohemeral variation in adolescents and young adults with IDDM: relation to endothelin 1 and indices of diabetic angiopathy. 54 61
11517960 1998
16
[Endothelin-1 and its role in diabetes mellitus]. 54 61
9432637 1997
17
Vascular damage and not hypertension per se influences endothelin-1 plasma levels in patients with non insulin dependent diabetes mellitus. 54 61
9270291 1997
18
[The characteristics of the peripheral blood monocytes in diabetics]. 61 54
9173581 1997
19
[Effects of xenotransplantation of pancreatic islet cells on immunological state of patients with diabetic angiopathies]. 61 54
9511343 1997
20
Somatostatin, growth hormone, insulin-like growth factor-1, and diabetes: friends or foes? 54 61
8769394 1996
21
Prostacyclin-stimulating factor, novel protein, and diabetic angiopathy. 54 61
8674874 1996
22
[The results of a comparative study of the lipid peroxidation processes and of the malondialdehyde level of the blood cells in patients with diabetic angiopathies and during insulin therapy]. 54 61
7863440 1994
23
[Cost of the treatments of arterial hypertension associated with diabetes]. 54 61
8206192 1993
24
Antioxidants in the serum of children with insulin-dependent diabetes mellitus. 61 54
8138185 1993
25
[N-acetyl-beta-glucosaminidase (beta-NAG) in urine: a parameter for early detection of diabetogenic nephropathy in childhood]. 61 54
8367178 1993
26
[Change of the complement level in patients with insulin-dependent diabetes mellitus in the course of intensified insulin therapy]. 54 61
1513764 1992
27
[Treatment of purulent-necrotic diseases in patients with diabetes mellitus]. 54 61
1619870 1992
28
[Acupuncture in the treatment of diabetic angiopathy of the lower extremities]. 54 61
1788185 1991
29
[Soluble thrombomodulin: a specific parameter of endothelial injury]. 61 54
1851235 1991
30
Organelle dynamics of endothelial mitochondria in diabetic angiopathy. 61
33460616 2021
31
Transcriptional profiling of mouse cavernous pericytes under high-glucose conditions: Implications for diabetic angiopathy. 61
33258327 2021
32
Salvia Miltiorrhiza in Anti-diabetic Angiopathy. 61
33430756 2021
33
LncRNA UCA1 stimulates the repair of hyperglycemic vascular smooth muscle cells through targeting miR-582-5p. 61
33378036 2020
34
miR-503/Apelin-12 mediates high glucose-induced microvascular endothelial cells injury via JNK and p38MAPK signaling pathway. 61
31989001 2020
35
Naringin inhibits autophagy mediated by PI3K-Akt-mTOR pathway to ameliorate endothelial cell dysfunction induced by high glucose/high fat stress. 61
32045600 2020
36
Differences in foot care practice between participants at risk for and with diabetic foot ulcers (DFUs) in community. 61
32204131 2020
37
MiR-20a ameliorates diabetic angiopathy in streptozotocin-induced diabetic rats by regulating intracellular antioxidant enzymes and VEGF. 61
32141587 2020
38
Resveratrol Attenuates High Glucose-Induced Vascular Endothelial Cell Injury by Activating the E2F3 Pathway. 61
32420356 2020
39
Protective Effects and Mechanisms of Vaccarin on Vascular Endothelial Dysfunction in Diabetic Angiopathy. 61
31533227 2019
40
Evaluation of the Occlusive Arterial Disease and Diabetic Angiopathy Treatment Effects by Hyperbaric Oxygenation. 61
31762558 2019
41
Rare cause of stroke in young: Iron deficiency anemia and diabetic ketoacidosis. 61
31198755 2019
42
Immunoregulatory Siglec ligands are abundant in human and mouse aorta and are up-regulated by high glucose. 61
30471282 2019
43
Synthesis, Metabolism, and Signaling Mechanisms of Hydrogen Sulfide: An Overview. 61
31148102 2019
44
Suppression of Oxygen Radicals Protects Diabetic Endothelium Damage and Tissue Perfusion in a Streptozotocin-Induced Diabetes Rodent Model. 61
30540602 2019
45
Hongjingtian Injection Inhibits Proliferation and Migration and Promotes Apoptosis in High Glucose-Induced Vascular Smooth Muscle Cells. 61
31827318 2019
46
Detecting Vascular Age Using the Analysis of Peripheral Pulse. 61
29993447 2018
47
Huayu Tongmai Granules protects against vascular endothelial dysfunction via up-regulating miR-185 and down-regulating RAGE. 61
30201694 2018
48
Is Skin Tag Associated with Diabetic Macro and Microangiopathy? 61
30129497 2018
49
[Operative treatment of diabetics with vascular complications : Secondary data analysis of diagnosis-related groups statistics from 2005 to 2014 in Germany]. 61
29589075 2018
50
MicroRNA-216b actively modulates diabetic angiopathy through inverse regulation on FZD5. 61
29477872 2018

Variations for Diabetic Angiopathy

Expression for Diabetic Angiopathy

Search GEO for disease gene expression data for Diabetic Angiopathy.

Pathways for Diabetic Angiopathy

Pathways related to Diabetic Angiopathy according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.44 TNFSF10 TNFRSF11B SOD2 PDGFRB NOS3 NOS2
2
Show member pathways
13.06 TNFSF10 SOD2 SELE NOS3 NOS2 CCL2
3
Show member pathways
12.44 PDGFRB NOS3 NOS2 FN1 CCL2
4 12.34 SOD2 MTHFR INS IGFBP7 CAT
5
Show member pathways
12.26 SELE NOS3 NOS2 CCL2
6
Show member pathways
11.99 SOD2 MTHFR INS CCL2 CAT
7
Show member pathways
11.91 TNFSF10 SOD2 INS CAT
8 11.75 INS FN1 BMP6
9 11.71 NOS3 NOS2 INS EDN1
10 11.67 SOD2 NOS2 CAT
11 11.57 VWF PDGFRB NOS3 CCL2
12 11.54 NOS2 EDN1 ADM
13 11.5 THBD SELE NOS3 EDN1 CCL2
14 11.45 SELE NOS2 INS
15 11.28 NOS3 NOS2 INS AGER
16
Show member pathways
11.27 NOS3 NOS2 CAT
17 11.17 THBD SELE NOS3 FN1 EDN1 CCL2
18 11.14 THBD NOS3 CCL2
19 10.89 TNFSF10 PDGFRB FN1 CCL2 BMP6
20 10.75 TNFRSF11B PDGFRB
21 10.7 NOS3 NOS2
22 10.46 NOS3 NOS2

GO Terms for Diabetic Angiopathy

Cellular components related to Diabetic Angiopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 VWF TNFSF10 TNFRSF11B INS IGFBP7 FN1
2 extracellular space GO:0005615 9.44 VWF TNFSF10 TNFRSF11B THBD SELE INS
3 Weibel-Palade body GO:0033093 9.16 VWF EDN1

Biological processes related to Diabetic Angiopathy according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 10.05 SOD2 NOS3 NOS2 MTHFR CAT AOC3
2 cell adhesion GO:0007155 10 VWF SELE IGFBP7 FN1 CCL2 AOC3
3 positive regulation of cell proliferation GO:0008284 9.93 PDGFRB INS FN1 EDN1 BMP6 ADM
4 positive regulation of cell migration GO:0030335 9.92 SOD2 PDGFRB INS EDN1
5 aging GO:0007568 9.85 SOD2 PDGFRB CAT ADM
6 response to drug GO:0042493 9.83 TNFRSF11B SOD2 MTHFR EDN1 CAT
7 cellular response to interferon-gamma GO:0071346 9.82 NOS2 EDN1 CCL2
8 response to insulin GO:0032868 9.79 TNFSF10 CAT ADM
9 regulation of blood pressure GO:0008217 9.77 SOD2 NOS3 EDN1
10 response to hydrogen peroxide GO:0042542 9.73 SOD2 PDGFRB CAT
11 inflammatory response GO:0006954 9.7 SELE NOS2 CCL2 BMP6 AOC3 AGER
12 response to retinoic acid GO:0032526 9.67 PDGFRB IGFBP7 BMP6
13 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.67 PDGFRB INS FN1 CAT
14 response to hyperoxia GO:0055093 9.65 PDGFRB CAT
15 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176 9.64 SOD2 INS
16 negative regulation of blood coagulation GO:0030195 9.63 THBD EDN1
17 response to magnesium ion GO:0032026 9.63 TNFRSF11B BMP6
18 removal of superoxide radicals GO:0019430 9.62 SOD2 NOS3
19 response to wounding GO:0009611 9.62 VWF FN1 AGER ADM
20 positive regulation of guanylate cyclase activity GO:0031284 9.61 NOS3 NOS2
21 negative regulation of platelet activation GO:0010544 9.6 THBD NOS3
22 response to fluid shear stress GO:0034405 9.58 PDGFRB NOS3
23 positive regulation of mitotic nuclear division GO:0045840 9.58 PDGFRB INS EDN1
24 arginine catabolic process GO:0006527 9.57 NOS3 NOS2
25 response to activity GO:0014823 9.56 SOD2 EDN1 CAT BMP6
26 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.54 NOS3 EDN1
27 response to L-ascorbic acid GO:0033591 9.51 SOD2 CAT
28 response to hypoxia GO:0001666 9.5 SOD2 NOS2 MTHFR EDN1 CAT AGER
29 response to ozone GO:0010193 9.48 EDN1 CAT
30 response to lipopolysaccharide GO:0032496 9.17 THBD SOD2 SELE NOS3 NOS2 EDN1

Molecular functions related to Diabetic Angiopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 10.03 VWF TNFSF10 SOD2 INS FN1 CAT
2 oxidoreductase activity GO:0016491 9.85 SOD2 NOS3 NOS2 MTHFR CAT AOC3
3 flavin adenine dinucleotide binding GO:0050660 9.63 NOS3 NOS2 MTHFR
4 cytokine activity GO:0005125 9.55 TNFSF10 TNFRSF11B EDN1 CCL2 BMP6
5 arginine binding GO:0034618 9.48 NOS3 NOS2
6 signaling receptor binding GO:0005102 9.43 TNFSF10 PDGFRB FN1 EDN1 CCL2 ADM
7 NADPH-hemoprotein reductase activity GO:0003958 9.4 NOS3 NOS2
8 tetrahydrobiopterin binding GO:0034617 9.32 NOS3 NOS2
9 nitric-oxide synthase activity GO:0004517 9.26 NOS3 NOS2
10 NADP binding GO:0050661 8.92 NOS3 NOS2 MTHFR CAT

Sources for Diabetic Angiopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....