MCID: DBT002
MIFTS: 44

Diabetic Autonomic Neuropathy

Categories: Neuronal diseases

Aliases & Classifications for Diabetic Autonomic Neuropathy

MalaCards integrated aliases for Diabetic Autonomic Neuropathy:

Name: Diabetic Autonomic Neuropathy 12 55 15 73
Diabetic Neuropathies 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:11503
MeSH 44 D003929
NCIt 50 C27068
SNOMED-CT 68 50620007

Summaries for Diabetic Autonomic Neuropathy

MalaCards based summary : Diabetic Autonomic Neuropathy, also known as diabetic neuropathies, is related to diabetic neuropathy and microvascular complications of diabetes 1, and has symptoms including sciatica and neuralgia. An important gene associated with Diabetic Autonomic Neuropathy is AKR1B1 (Aldo-Keto Reductase Family 1 Member B), and among its related pathways/superpathways are PI3K-Akt signaling pathway and p75(NTR)-mediated signaling. The drugs Quinapril and Donepezil have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and bone, and related phenotype is vision/eye.

Related Diseases for Diabetic Autonomic Neuropathy

Diseases related to Diabetic Autonomic Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 126)
# Related Disease Score Top Affiliating Genes
1 diabetic neuropathy 33.5 AKR1B1 EPO INS NGF NTF3
2 microvascular complications of diabetes 1 32.6 AKR1B1 INS NTF3
3 microvascular complications of diabetes 5 32.0 AKR1B1 INS
4 autonomic neuropathy 31.6 AKR1B1 INS NGF
5 diabetic polyneuropathy 29.9 AKR1B1 NGF NTF3
6 peripheral nervous system disease 29.7 AKR1B1 INS NGF
7 microvascular complications of diabetes 3 11.3
8 microvascular complications of diabetes 4 11.3
9 microvascular complications of diabetes 6 11.3
10 microvascular complications of diabetes 7 11.3
11 neuropathy 11.1
12 microvascular complications of diabetes 2 10.9
13 abducens nerve disease 10.9
14 argyll robertson pupil 10.9
15 syncope 10.9
16 postural hypotension 10.4
17 hypoglycemia 10.3
18 diabetes mellitus, noninsulin-dependent 10.2
19 polyneuropathy 10.2
20 sheehan syndrome 10.2 EPO INS
21 plethora of newborn 10.2 EPO INS
22 fetal erythroblastosis 10.1 EPO INS
23 postherpetic neuralgia 10.1
24 functional gastric disease 10.1 INS MLNR
25 type 1 diabetes mellitus 7 10.1 HBA2 INS
26 type 1 diabetes mellitus 11 10.1 HBA2 INS
27 background diabetic retinopathy 10.1 HBA2 INS
28 neonatal anemia 10.1 EPO HBA2
29 cardiac conduction defect 10.1
30 iritis 10.1
31 type 1 diabetes mellitus 5 10.1 HBA2 INS
32 rubeosis iridis 10.1 HBA2 INS
33 splenomegaly 10.1 EPO HBA2
34 hemoglobin h disease 10.1 EPO HBA2
35 sickle cell disease 10.1 EPO HBA2
36 uremia 10.0 EPO INS
37 hemoglobinopathy 10.0 EPO HBA2
38 microcytic anemia 10.0 EPO HBA2
39 endocrine organ benign neoplasm 10.0 INS NGF
40 depression 10.0
41 congenital hemolytic anemia 10.0 EPO HBA2
42 ocular dominance 10.0 NGF NTF3
43 sickle cell anemia 10.0 EPO HBA2
44 myocardial infarction 10.0
45 diabetes mellitus 10.0
46 sexual disorder 10.0
47 retinal vascular disease 10.0 AKR1B1 HBA2 INS
48 anxiety 10.0
49 hypoglycemic coma 10.0 HBA2 INS NTF3
50 sensory peripheral neuropathy 9.9 NGF NTF3

Graphical network of the top 20 diseases related to Diabetic Autonomic Neuropathy:



Diseases related to Diabetic Autonomic Neuropathy

Symptoms & Phenotypes for Diabetic Autonomic Neuropathy

UMLS symptoms related to Diabetic Autonomic Neuropathy:


sciatica, neuralgia

MGI Mouse Phenotypes related to Diabetic Autonomic Neuropathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.02 AKR1B1 AOC1 INS NGF NTF3

Drugs & Therapeutics for Diabetic Autonomic Neuropathy

Drugs for Diabetic Autonomic Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 75)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Quinapril Approved, Investigational Phase 4 85441-61-8 54892
2
Donepezil Approved Phase 4,Not Applicable 120014-06-4 3152
3
Bromocriptine Approved, Investigational Phase 4 25614-03-3 31101
4
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
5
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
6
Norepinephrine Approved Phase 4 51-41-2 439260
7
gamma-Aminobutyric acid Approved, Investigational Phase 4 56-12-2 119
8 HIV Protease Inhibitors Phase 4,Phase 2
9
protease inhibitors Phase 4,Phase 2
10 Antihypertensive Agents Phase 4
11 Angiotensin-Converting Enzyme Inhibitors Phase 4
12 Hormones Phase 4,Phase 2
13 Hormone Antagonists Phase 4,Phase 2
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2
15 Calcium, Dietary Phase 4,Phase 2
16 Central Nervous System Depressants Phase 4,Phase 2
17 Peripheral Nervous System Agents Phase 4,Phase 2
18 Tranquilizing Agents Phase 4,Phase 2
19 Psychotropic Drugs Phase 4,Phase 2
20 Anti-Anxiety Agents Phase 4,Phase 2
21 Analgesics Phase 4,Phase 2
22 calcium channel blockers Phase 4,Phase 2
23 Anticonvulsants Phase 4,Phase 2
24 Neurotransmitter Agents Phase 4,Not Applicable
25 Cholinesterase Inhibitors Phase 4,Not Applicable
26 Cholinergic Agents Phase 4,Not Applicable
27 Nootropic Agents Phase 4,Not Applicable
28 Dopamine Agents Phase 4
29 Antiparkinson Agents Phase 4
30 Dopamine agonists Phase 4
31 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4
32 Excitatory Amino Acid Antagonists Phase 4
33 GABA Agents Phase 4
34 Antidepressive Agents Phase 4
35 Neurotransmitter Uptake Inhibitors Phase 4
36 Antimanic Agents Phase 4
37 Duloxetine Hydrochloride Phase 4
38 Excitatory Amino Acids Phase 4
39
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
40
Nicotinamide Approved, Investigational Phase 3 98-92-0 936
41
Allopurinol Approved Phase 3 315-30-0 2094
42
Zinc Approved, Investigational Phase 3 7440-66-6
43
Niacin Approved, Investigational, Nutraceutical Phase 3 59-67-6 938
44
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
45 Hypolipidemic Agents Phase 3
46 Lipid Regulating Agents Phase 3
47 Vitamin B3 Phase 3
48 Micronutrients Phase 3
49 Nicotinic Acids Phase 3
50 Vasodilator Agents Phase 3,Not Applicable

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Inspiratory Muscle Training in Patients With Autonomic Neuropathic Unknown status NCT00752440 Phase 4
2 Efficacy of Administration of ACE-Inhibition on Autonomic and Peripheral Neuropathy in Patients With Diabetes Mellitus Completed NCT03031834 Phase 4 Quinapril
3 Bromocriptine-QR Therapy on Sympathetic Tone and Vascular Biology in Type 2 Diabetes Subjects Active, not recruiting NCT02682901 Phase 4 Cycloset;Placebo
4 Three Way Interaction Between Gabapentin, Duloxetine, and Donepezil in Patients With Diabetic Neuropathy Terminated NCT00619983 Phase 4 donepezil;duloxetine;donepezil 2.5 mg and duloxetine 30mg;placebo;gabapentin
5 An Intervention Trial for Cardiac Neuropathy in Type 1 Diabetes Completed NCT00116207 Phase 3 ORAL ANTIOXIDANT
6 Anti-Nephropathic Effects of Chronic Intermittent Intravenous Insulin Therapy (CIIIT) Completed NCT00594152 Phase 3 CIIIT
7 Effect of Autonomic Neuropathy on the Efficacy of a DPP-IV Inhibitor (Galvus) Therapy Completed NCT01452113 Phase 2 Vildagliptin
8 Efficacy and Safety of TAK-583 in Subjects With Diabetic Peripheral Neuropathy Completed NCT00760955 Phase 2 TAK-583;TAK-583;TAK-583;Placebo
9 A Multicenter Study Comparing the Analgesic Effects and Safety of ABT-639 Compared to Placebo in Subjects With Diabetic Neuropathic Pain Completed NCT01345045 Phase 2 ABT-639;pregabalin;Placebo
10 A Comparison Between Pupillometry, Heart Rate Variability and Metaiodobenzylguanidine Scintigraphy for the Diagnosis of Early Diabetic Autonomic Neuropathy in Type 1 Diabetes Unknown status NCT01822431
11 The Relative Prevalence and Severity of Autonomic Nervous System Dysfunction Completed NCT00919347
12 Coronary Blood Flow Regulation During General Anesthesia Completed NCT00866801
13 Gastrointestinal Motility Among Diabetes Patients Recruiting NCT02573519 Not Applicable 3D-Transit during treatment with Pyridostigmine
14 Chongqing Diabetes Registry Study Recruiting NCT03692884

Search NIH Clinical Center for Diabetic Autonomic Neuropathy

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: diabetic neuropathies

Genetic Tests for Diabetic Autonomic Neuropathy

Anatomical Context for Diabetic Autonomic Neuropathy

MalaCards organs/tissues related to Diabetic Autonomic Neuropathy:

41
Heart, Testes, Bone, Brain, Spinal Cord, Bone Marrow, Eye

Publications for Diabetic Autonomic Neuropathy

Articles related to Diabetic Autonomic Neuropathy:

(show top 50) (show all 367)
# Title Authors Year
1
Diabetic autonomic neuropathy resulting in sexual dysfunction. ( 30256272 )
2018
2
Diabetic autonomic neuropathy resulting in sexual dysfunction. ( 30320635 )
2018
3
Catechin attenuates diabetic autonomic neuropathy in streptozotocin induced diabetic rats. ( 30372853 )
2018
4
Managing supine hypertension in a patient with non-diabetic autonomic neuropathy receiving droxidopa for neurogenic orthostatic hypotension. ( 28623420 )
2017
5
Treatment of Diabetic Autonomic Neuropathy in Older Adults with Diabetes Mellitus. ( 28107120 )
2016
6
Inflammation as a Therapeutic Target for Diabetic Neuropathies. ( 26897744 )
2016
7
Current Ideas on the Treatment Of Diabetic Neuropathies. ( 30058872 )
2016
8
Morphologic Changes in Autonomic Nerves in Diabetic Autonomic Neuropathy. ( 26706915 )
2015
9
Inspiratory muscle training in patients with diabetic autonomic neuropathy: a randomized clinical trial. ( 25982993 )
2015
10
Role of Microcirculatory Disturbances and Diabetic Autonomic Neuropathy in Takotsubo Cardiomyopathy. ( 26468716 )
2015
11
Sensory manifestations of diabetic neuropathies: anatomical and clinical correlations. ( 25614497 )
2015
12
Identifying Common Genetic Risk Factors of Diabetic Neuropathies. ( 26074879 )
2015
13
Diabetic Neuropathies. ( 26502765 )
2015
14
Association of diabetic autonomic neuropathy with red blood cell aldose reductase activity. ( 24485209 )
2014
15
Diabetic autonomic neuropathy. ( 25410215 )
2014
16
Disproportionate pupillary involvement in diabetic autonomic neuropathy. ( 25377131 )
2014
17
CORNEAL confocal microscopy for the diagnosis of diabetic autonomic neuropathy. ( 25556884 )
2014
18
Calcium signalling in sensory neurones and peripheral glia in the context of diabetic neuropathies. ( 25149565 )
2014
19
Diabetic neuropathies. ( 25299279 )
2014
20
Diabetic autonomic neuropathy. ( 24095132 )
2013
21
Diabetic autonomic neuropathy affects symptom generation and brain-gut axis. ( 24026548 )
2013
22
Muscle strength and ankle mobility for the gait parameters in diabetic neuropathies. ( 23274122 )
2013
23
Alpha lipoic acid and glycaemic control in diabetic neuropathies at type 2 diabetes treatment. ( 23678828 )
2013
24
Diabetic neuropathies: diagnosis and management. ( 24458095 )
2013
25
What is the ideal biological marker in diagnosis of diabetic neuropathies? ( 24843646 )
2013
26
Mortality after acute myocardial infarction: significance of cardiovascular diabetic autonomic neuropathy (CDAN). ( 23097964 )
2012
27
Diabetic autonomic neuropathy. ( 23393679 )
2012
28
Highlights in clinical autonomic neuroscience: latest developments in the early detection of diabetic autonomic neuropathy. ( 22306250 )
2012
29
The diabetic neuropathies: practical and rational therapy. ( 23117944 )
2012
30
The relationship between diabetic autonomic neuropathy and diabetic risk factors in a Taiwanese population. ( 21986117 )
2011
31
The effect of diabetic autonomic neuropathy on P-wave duration, dispersion and atrial fibrillation. ( 22291825 )
2011
32
Recommendations for the use of cardiovascular tests in diagnosing diabetic autonomic neuropathy. ( 21247746 )
2011
33
Vasopressin release induced by hypothension is blunted in patients with diabetic autonomic neuropathy. ( 20370555 )
2011
34
Severe orthostatic hypotension in a diabetic patient may not be due to diabetic autonomic neuropathy. ( 21902089 )
2011
35
Effects of an exercise program on balance and trunk proprioception in older adults with diabetic neuropathies. ( 21561371 )
2011
36
Effect of acute hyperglycaemia on sensory processing in diabetic autonomic neuropathy. ( 20624170 )
2010
37
Gastric mucosal nerve density: a biomarker for diabetic autonomic neuropathy? ( 20837965 )
2010
38
Different effects of diabetic autonomic neuropathy on regional transcutaneous oxygen tension in patients with peripheral arterial disease. ( 21466127 )
2010
39
Role of 12/15-lipoxygenase in nitrosative stress and peripheral prediabetic and diabetic neuropathies. ( 20599608 )
2010
40
Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments. ( 20876709 )
2010
41
Cough reflex sensitivity in adolescents with diabetic autonomic neuropathy. ( 20156724 )
2009
42
New insights in diabetic autonomic neuropathy in children and adolescents. ( 19734243 )
2009
43
A pharmacologic pupillary test in the diagnosis of diabetic autonomic neuropathy. ( 20046691 )
2009
44
Erythropoietin and its carbamylated derivative prevent the development of experimental diabetic autonomic neuropathy in STZ-induced diabetic NOD-SCID mice. ( 17967455 )
2008
45
Dynamic cerebral autoregulation assessment using chaotic analysis in diabetic autonomic neuropathy. ( 17874153 )
2008
46
The impact of diabetic autonomic neuropathy on the incretin effect. ( 18376350 )
2008
47
The spectrum of diabetic neuropathies. ( 18194747 )
2008
48
Diabetic neuropathies: components of etiology. ( 18601656 )
2008
49
Ergotamine use in severe diabetic autonomic neuropathy. ( 17227338 )
2007
50
Gut sensations in diabetic autonomic neuropathy. ( 17521809 )
2007

Variations for Diabetic Autonomic Neuropathy

Expression for Diabetic Autonomic Neuropathy

Search GEO for disease gene expression data for Diabetic Autonomic Neuropathy.

Pathways for Diabetic Autonomic Neuropathy

Pathways related to Diabetic Autonomic Neuropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.77 EPO INS NGF NTF3
2
Show member pathways
11.14 NGF NTF3
3
Show member pathways
11.04 NGF NTF3
4 10.84 EPO INS
5 10.61 NGF NTF3

GO Terms for Diabetic Autonomic Neuropathy

Cellular components related to Diabetic Autonomic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 AOC1 EPO HBA2 INS NGF NTF3
2 extracellular space GO:0005615 9.17 AKR1B1 AOC1 EPO HBA2 INS NGF

Biological processes related to Diabetic Autonomic Neuropathy according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.49 INS NTF3
2 neuron projection morphogenesis GO:0048812 9.48 NGF NTF3
3 modulation of chemical synaptic transmission GO:0050804 9.46 NGF NTF3
4 regulation of signaling receptor activity GO:0010469 9.46 EPO INS NGF NTF3
5 acute-phase response GO:0006953 9.43 EPO INS
6 activation of protein kinase B activity GO:0032148 9.4 INS NTF3
7 peripheral nervous system development GO:0007422 9.37 NGF NTF3
8 regulation of neuron differentiation GO:0045664 9.32 NGF NTF3
9 positive regulation of Ras protein signal transduction GO:0046579 9.26 EPO NGF
10 nerve development GO:0021675 8.96 NGF NTF3
11 nerve growth factor signaling pathway GO:0038180 8.62 NGF NTF3

Sources for Diabetic Autonomic Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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