MCID: DBT002
MIFTS: 43

Diabetic Autonomic Neuropathy

Categories: Neuronal diseases

Aliases & Classifications for Diabetic Autonomic Neuropathy

MalaCards integrated aliases for Diabetic Autonomic Neuropathy:

Name: Diabetic Autonomic Neuropathy 12 55 15 73
Diabetic Neuropathies 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:11503
MeSH 44 D003929
NCIt 50 C27068
SNOMED-CT 68 50620007
UMLS 73 C0271686

Summaries for Diabetic Autonomic Neuropathy

MalaCards based summary : Diabetic Autonomic Neuropathy, also known as diabetic neuropathies, is related to diabetic neuropathy and microvascular complications of diabetes 5, and has symptoms including neuralgia and sciatica. An important gene associated with Diabetic Autonomic Neuropathy is AKR1B1 (Aldo-Keto Reductase Family 1 Member B), and among its related pathways/superpathways are PI3K-Akt signaling pathway and p75(NTR)-mediated signaling. The drugs Quinapril and Bromocriptine have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and pancreatic islet, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Diabetic Autonomic Neuropathy

Diseases related to Diabetic Autonomic Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Related Disease Score Top Affiliating Genes
1 diabetic neuropathy 32.1 AKR1B1 EPO INS NGF NTF3
2 microvascular complications of diabetes 5 31.9 AKR1B1 INS
3 autonomic neuropathy 31.2 AKR1B1 INS NGF
4 postural hypotension 30.3 DBH INS
5 peripheral nervous system disease 29.4 INS NGF
6 microvascular complications of diabetes 1 11.5
7 neuropathy 11.0
8 sheehan syndrome 10.5 EPO INS
9 fetal erythroblastosis 10.4 EPO INS
10 hypoglycemic coma 10.4 INS NTF3
11 microvascular complications of diabetes 3 10.4 AKR1B1 INS
12 retinal vascular disease 10.3 AKR1B1 INS
13 pancreatitis 10.2
14 hypoglycemia 10.2
15 ocular dominance 10.1 NGF NTF3
16 cardiac conduction defect 10.0
17 diabetes mellitus 10.0
18 iritis 10.0
19 uremia 10.0 EPO INS
20 sensory peripheral neuropathy 10.0 NGF NTF3
21 aging 9.9
22 myocardial infarction 9.9
23 early-onset schizophrenia 9.9 DBH INS
24 renal hypertension 9.9 DBH EPO
25 pure autonomic failure 9.8 DBH EPO
26 keratoconjunctivitis 9.8 AOC1 NGF
27 diabetic polyneuropathy 9.7 AKR1B1 NGF NTF3
28 arteries, anomalies of 9.7
29 pheochromocytoma 9.7
30 neuroblastoma 9.7
31 insulin-like growth factor i 9.7
32 reflex sympathetic dystrophy 9.7
33 resting heart rate, variation in 9.7
34 acute myocardial infarction 9.7
35 peripheral artery disease 9.7
36 atrial fibrillation 9.7
37 mucositis 9.7
38 esophagitis 9.7
39 algoneurodystrophy 9.7
40 vascular disease 9.7
41 gastric dilatation 9.7
42 cerebritis 9.7
43 type i 9.7
44 primary orthostatic hypotension 9.7
45 autonomic dysfunction 9.7
46 dysautonomia 9.7
47 hypoxia 9.7
48 urinary system disease 9.7 EPO INS
49 neuropathy, hereditary sensory and autonomic, type iii 9.6 DBH NGF
50 autonomic nervous system disease 9.2 DBH INS NGF

Graphical network of the top 20 diseases related to Diabetic Autonomic Neuropathy:



Diseases related to Diabetic Autonomic Neuropathy

Symptoms & Phenotypes for Diabetic Autonomic Neuropathy

UMLS symptoms related to Diabetic Autonomic Neuropathy:


neuralgia, sciatica

MGI Mouse Phenotypes related to Diabetic Autonomic Neuropathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.73 AOC1 DBH EPO INS NGF NTF3
2 homeostasis/metabolism MP:0005376 9.7 AKR1B1 AOC1 DBH EPO INS NGF
3 normal MP:0002873 9.35 INS NGF NTF3 DBH EPO
4 vision/eye MP:0005391 9.1 AKR1B1 AOC1 DBH INS NGF NTF3

Drugs & Therapeutics for Diabetic Autonomic Neuropathy

Drugs for Diabetic Autonomic Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 74)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Quinapril Approved, Investigational Phase 4 85441-61-8 54892
2
Bromocriptine Approved, Investigational Phase 4 25614-03-3 31101
3
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
4
Donepezil Approved Phase 4,Not Applicable 120014-06-4 3152
5
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
6
gamma-Aminobutyric acid Approved, Investigational Phase 4 56-12-2 119
7
Norepinephrine Approved Phase 4 51-41-2 439260
8 Angiotensin-Converting Enzyme Inhibitors Phase 4
9 Antihypertensive Agents Phase 4
10 HIV Protease Inhibitors Phase 4,Phase 2
11
protease inhibitors Phase 4,Phase 2
12 Hormone Antagonists Phase 4,Phase 2
13 Hormones Phase 4,Phase 2
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2
15 Analgesics Phase 4,Phase 2
16 Anti-Anxiety Agents Phase 4,Phase 2
17 Anticonvulsants Phase 4,Phase 2
18 calcium channel blockers Phase 4,Phase 2
19 Calcium, Dietary Phase 4,Phase 2
20 Central Nervous System Depressants Phase 4,Phase 2
21 Peripheral Nervous System Agents Phase 4,Phase 2
22 Psychotropic Drugs Phase 4,Phase 2
23 Tranquilizing Agents Phase 4,Phase 2
24 Antiparkinson Agents Phase 4
25 Dopamine Agents Phase 4
26 Dopamine agonists Phase 4
27 Neurotransmitter Agents Phase 4,Not Applicable
28 Cholinergic Agents Phase 4,Not Applicable
29 Cholinesterase Inhibitors Phase 4,Not Applicable
30 Nootropic Agents Phase 4,Not Applicable
31 Antidepressive Agents Phase 4
32 Antimanic Agents Phase 4
33 Duloxetine Hydrochloride Phase 4
34 Excitatory Amino Acid Antagonists Phase 4
35 Excitatory Amino Acids Phase 4
36 GABA Agents Phase 4
37 Neurotransmitter Uptake Inhibitors Phase 4
38 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4
39
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
40
Allopurinol Approved Phase 3 315-30-0 2094
41
Zinc Approved, Investigational Phase 3 7440-66-6 23994
42
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
43
Niacin Approved, Investigational, Nutraceutical Phase 3 59-67-6 938
44
Nicotinamide Approved, Investigational, Nutraceutical Phase 3 98-92-0 936
45 Antimetabolites Phase 3
46 Antioxidants Phase 3
47 Antirheumatic Agents Phase 3
48 Hypolipidemic Agents Phase 3
49 Lipid Regulating Agents Phase 3
50 Micronutrients Phase 3

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Inspiratory Muscle Training in Patients With Autonomic Neuropathic Unknown status NCT00752440 Phase 4
2 Efficacy of Administration of ACE-Inhibition on Autonomic and Peripheral Neuropathy in Patients With Diabetes Mellitus Completed NCT03031834 Phase 4 Quinapril
3 Bromocriptine-QR Therapy on Sympathetic Tone and Vascular Biology in Type 2 Diabetes Subjects Recruiting NCT02682901 Phase 4 Cycloset;Placebo
4 Three Way Interaction Between Gabapentin, Duloxetine, and Donepezil in Patients With Diabetic Neuropathy Terminated NCT00619983 Phase 4 donepezil;duloxetine;donepezil 2.5 mg and duloxetine 30mg;placebo;gabapentin
5 An Intervention Trial for Cardiac Neuropathy in Type 1 Diabetes Completed NCT00116207 Phase 3 ORAL ANTIOXIDANT
6 Anti-Nephropathic Effects of Chronic Intermittent Intravenous Insulin Therapy (CIIIT) Completed NCT00594152 Phase 3 CIIIT
7 Effect of Autonomic Neuropathy on the Efficacy of a DPP-IV Inhibitor (Galvus) Therapy Completed NCT01452113 Phase 2 Vildagliptin
8 Efficacy and Safety of TAK-583 in Subjects With Diabetic Peripheral Neuropathy Completed NCT00760955 Phase 2 TAK-583;TAK-583;TAK-583;Placebo
9 A Multicenter Study Comparing the Analgesic Effects and Safety of ABT-639 Compared to Placebo in Subjects With Diabetic Neuropathic Pain Completed NCT01345045 Phase 2 ABT-639;pregabalin;Placebo
10 A Comparison Between Pupillometry, Heart Rate Variability and Metaiodobenzylguanidine Scintigraphy for the Diagnosis of Early Diabetic Autonomic Neuropathy in Type 1 Diabetes Unknown status NCT01822431
11 The Relative Prevalence and Severity of Autonomic Nervous System Dysfunction Completed NCT00919347
12 Coronary Blood Flow Regulation During General Anesthesia Completed NCT00866801
13 Gastrointestinal Motility Among Diabetes Patients Recruiting NCT02573519 Not Applicable 3D-Transit during treatment with Pyridostigmine

Search NIH Clinical Center for Diabetic Autonomic Neuropathy

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: diabetic neuropathies

Genetic Tests for Diabetic Autonomic Neuropathy

Anatomical Context for Diabetic Autonomic Neuropathy

MalaCards organs/tissues related to Diabetic Autonomic Neuropathy:

41
Heart, Testes, Pancreatic Islet, Skin, Eye, Brain

Publications for Diabetic Autonomic Neuropathy

Articles related to Diabetic Autonomic Neuropathy:

(show top 50) (show all 292)
# Title Authors Year
1
Managing supine hypertension in a patient with non-diabetic autonomic neuropathy receiving droxidopa for neurogenic orthostatic hypotension. ( 28623420 )
2017
2
Treatment of Diabetic Autonomic Neuropathy in Older Adults with Diabetes Mellitus. ( 28107120 )
2016
3
Morphologic Changes in Autonomic Nerves in Diabetic Autonomic Neuropathy. ( 26706915 )
2015
4
Inspiratory muscle training in patients with diabetic autonomic neuropathy: a randomized clinical trial. ( 25982993 )
2015
5
Role of Microcirculatory Disturbances and Diabetic Autonomic Neuropathy in Takotsubo Cardiomyopathy. ( 26468716 )
2015
6
Association of diabetic autonomic neuropathy with red blood cell aldose reductase activity. ( 24485209 )
2014
7
Diabetic autonomic neuropathy. ( 25410215 )
2014
8
Disproportionate pupillary involvement in diabetic autonomic neuropathy. ( 25377131 )
2014
9
CORNEAL confocal microscopy for the diagnosis of diabetic autonomic neuropathy. ( 25556884 )
2014
10
Diabetic autonomic neuropathy. ( 24095132 )
2013
11
Diabetic autonomic neuropathy affects symptom generation and brain-gut axis. ( 24026548 )
2013
12
Mortality after acute myocardial infarction: significance of cardiovascular diabetic autonomic neuropathy (CDAN). ( 23097964 )
2012
13
Diabetic autonomic neuropathy. ( 23393679 )
2012
14
Highlights in clinical autonomic neuroscience: latest developments in the early detection of diabetic autonomic neuropathy. ( 22306250 )
2012
15
The relationship between diabetic autonomic neuropathy and diabetic risk factors in a Taiwanese population. ( 21986117 )
2011
16
The effect of diabetic autonomic neuropathy on P-wave duration, dispersion and atrial fibrillation. ( 22291825 )
2011
17
Recommendations for the use of cardiovascular tests in diagnosing diabetic autonomic neuropathy. ( 21247746 )
2011
18
Vasopressin release induced by hypothension is blunted in patients with diabetic autonomic neuropathy. ( 20370555 )
2011
19
Severe orthostatic hypotension in a diabetic patient may not be due to diabetic autonomic neuropathy. ( 21902089 )
2011
20
Effect of acute hyperglycaemia on sensory processing in diabetic autonomic neuropathy. ( 20624170 )
2010
21
Gastric mucosal nerve density: a biomarker for diabetic autonomic neuropathy? ( 20837965 )
2010
22
Different effects of diabetic autonomic neuropathy on regional transcutaneous oxygen tension in patients with peripheral arterial disease. ( 21466127 )
2010
23
Cough reflex sensitivity in adolescents with diabetic autonomic neuropathy. ( 20156724 )
2009
24
New insights in diabetic autonomic neuropathy in children and adolescents. ( 19734243 )
2009
25
A pharmacologic pupillary test in the diagnosis of diabetic autonomic neuropathy. ( 20046691 )
2009
26
Erythropoietin and its carbamylated derivative prevent the development of experimental diabetic autonomic neuropathy in STZ-induced diabetic NOD-SCID mice. ( 17967455 )
2008
27
Dynamic cerebral autoregulation assessment using chaotic analysis in diabetic autonomic neuropathy. ( 17874153 )
2008
28
The impact of diabetic autonomic neuropathy on the incretin effect. ( 18376350 )
2008
29
Ergotamine use in severe diabetic autonomic neuropathy. ( 17227338 )
2007
30
Gut sensations in diabetic autonomic neuropathy. ( 17521809 )
2007
31
Effect of quinapril or losartan alone and in combination on left ventricular systolic and diastolic functions in asymptomatic patients with diabetic autonomic neuropathy. ( 16389160 )
2006
32
Ergotamine use in severe diabetic autonomic neuropathy. ( 16681568 )
2006
33
Severe orthostatic hypotension with diabetic autonomic neuropathy successfully treated with a beta(1)-blocker: a case report. ( 16810280 )
2006
34
Images in clinical medicine. Gastric dilatation secondary to diabetic autonomic neuropathy. ( 16371635 )
2005
35
Acute dysautonomia: a rare manifestation of diabetic autonomic neuropathy masquerading as pheochromocytoma. ( 16279988 )
2005
36
Severe and disabling diabetic autonomic neuropathy: a case report. ( 15120708 )
2004
37
Pupillography refines the diagnosis of diabetic autonomic neuropathy. ( 15240199 )
2004
38
Diabetic autonomic neuropathy: evidence for apoptosis in situ in the rat. ( 15198656 )
2004
39
Use of heart rate reserve and rating of perceived exertion to prescribe exercise intensity in diabetic autonomic neuropathy. ( 12663561 )
2003
40
Diagnosis and management of diabetic autonomic neuropathy. ( 14606343 )
2003
41
Diabetic autonomic neuropathy: importance of its early detection for improving morbidity and mortality. ( 12879940 )
2003
42
Diabetic autonomic neuropathy. ( 15088257 )
2003
43
Diagnosis of diabetic autonomic neuropathy: a multivariate approach. ( 12864779 )
2003
44
Analysis of the Zucker Diabetic Fatty (ZDF) type 2 diabetic rat model suggests a neurotrophic role for insulin/IGF-I in diabetic autonomic neuropathy. ( 12819007 )
2003
45
Comparative neuropathology and diabetic autonomic neuropathy. ( 14578168 )
2003
46
Diabetic autonomic neuropathy. ( 12716821 )
2003
47
Non-obese diabetic mice rapidly develop dramatic sympathetic neuritic dystrophy: a new experimental model of diabetic autonomic neuropathy. ( 14578206 )
2003
48
Does diabetic autonomic neuropathy influence the clinical manifestations of reflux esophagitis? ( 14604253 )
2003
49
Diabetic autonomic neuropathy is associated with an increased incidence of strokes. ( 14614967 )
2003
50
The effectiveness of treatments of diabetic autonomic neuropathy is not the same in autonomic nerves supplying different organs. ( 12502507 )
2003

Variations for Diabetic Autonomic Neuropathy

Expression for Diabetic Autonomic Neuropathy

Search GEO for disease gene expression data for Diabetic Autonomic Neuropathy.

Pathways for Diabetic Autonomic Neuropathy

Pathways related to Diabetic Autonomic Neuropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.75 EPO INS NGF NTF3
2
Show member pathways
11.08 NGF NTF3
3
Show member pathways
10.94 NGF NTF3
4 10.64 EPO INS

GO Terms for Diabetic Autonomic Neuropathy

Cellular components related to Diabetic Autonomic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 AOC1 DBH EPO INS NGF NTF3
2 extracellular space GO:0005615 9.17 AKR1B1 AOC1 DBH EPO INS NGF

Biological processes related to Diabetic Autonomic Neuropathy according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.71 INS NGF NTF3
2 negative regulation of apoptotic process GO:0043066 9.71 AKR1B1 EPO INS NGF
3 neuron projection morphogenesis GO:0048812 9.55 NGF NTF3
4 positive regulation of DNA replication GO:0045740 9.52 EPO INS
5 modulation of chemical synaptic transmission GO:0050804 9.51 NGF NTF3
6 acute-phase response GO:0006953 9.49 EPO INS
7 activation of protein kinase B activity GO:0032148 9.48 INS NTF3
8 regulation of neuron differentiation GO:0045664 9.46 NGF NTF3
9 regulation of signaling receptor activity GO:0010469 9.46 EPO INS NGF NTF3
10 peripheral nervous system development GO:0007422 9.43 NGF NTF3
11 positive regulation of Ras protein signal transduction GO:0046579 9.37 EPO NGF
12 nerve development GO:0021675 9.32 NGF NTF3
13 locomotion GO:0040011 9.26 NGF NTF3
14 nerve growth factor signaling pathway GO:0038180 8.96 NGF NTF3
15 memory GO:0007613 8.8 DBH NGF NTF3

Molecular functions related to Diabetic Autonomic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 copper ion binding GO:0005507 8.62 AOC1 DBH

Sources for Diabetic Autonomic Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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