MCID: DBT007
MIFTS: 36

Diabetic Cataract

Categories: Eye diseases, Genetic diseases, Neuronal diseases

Aliases & Classifications for Diabetic Cataract

MalaCards integrated aliases for Diabetic Cataract:

Name: Diabetic Cataract 12 54 15 70 32
Cataract - Diabetic 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13328
ICD9CM 34 366.41
SNOMED-CT 67 43959009
ICD10 32 H28.0
UMLS 70 C0011876

Summaries for Diabetic Cataract

Disease Ontology : 12 A cataract that is characterized by loss of lens transparency secondary to hyperglycemia related to diabetes mellitus.

MalaCards based summary : Diabetic Cataract, also known as cataract - diabetic, is related to mature cataract and microvascular complications of diabetes 1. An important gene associated with Diabetic Cataract is AKR1B1 (Aldo-Keto Reductase Family 1 Member B), and among its related pathways/superpathways are Pathways in cancer and Sulfation Biotransformation Reaction. The drugs Ketorolac and Antirheumatic Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, cortex and endothelial.

Related Diseases for Diabetic Cataract

Diseases related to Diabetic Cataract via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Related Disease Score Top Affiliating Genes
1 mature cataract 29.9 CRYGS CRYAA AKR1B1
2 microvascular complications of diabetes 1 29.9 VEGFA SERPINF1 CRYAA AKR1B1
3 microvascular complications of diabetes 5 29.7 VEGFA SORD SERPINF1 CRYAA AKR1B1
4 macular retinal edema 29.7 VEGFA SERPINF1 CRYAA AKR1B1
5 background diabetic retinopathy 29.6 VEGFA SORD AKR1B1
6 senile cataract 29.4 SERPINF1 GSR G6PD CRYGS CRYAA
7 cataract 28.9 VEGFA SORD SERPINF1 MMP2 MIR204 GSR
8 hyperglycemia 10.4
9 retinal microaneurysm 10.3 VEGFA AKR1B1
10 severe nonproliferative diabetic retinopathy 10.3 VEGFA AKR1B1
11 odontogenic myxoma 10.3 VEGFA MMP2
12 eales disease 10.2 VEGFA SERPINF1
13 diabetic macular edema 10.2 VEGFA SERPINF1 AKR1B1
14 branch retinal artery occlusion 10.2 VEGFA CRYAA
15 central retinal artery occlusion 10.1 VEGFA CRYAA
16 endometrial adenocarcinoma 10.1 VEGFA MIR204 MALAT1
17 corneal disease 10.1 VEGFA CRYAA AKR1B1
18 buerger disease 10.1 VEGFA GSR
19 amelogenesis imperfecta, type ig 10.1 VEGFA SP1 AR
20 sorsby fundus dystrophy 10.1 VEGFA MMP2 CRYAA
21 macular dystrophy, dominant cystoid 10.1 VEGFA CRYAA
22 kuhnt-junius degeneration 10.1 VEGFA SERPINF1 CRYAA
23 retinal vascular occlusion 10.1 VEGFA SERPINF1 CRYAA
24 macular holes 10.1 VEGFA SERPINF1 CRYAA
25 corneal neovascularization 10.1 VEGFA SERPINF1 CRYAA
26 morgagni cataract 10.1 CRYGS CRYAA
27 degeneration of macula and posterior pole 10.0 VEGFA SERPINF1 CRYAA
28 early-onset lamellar cataract 10.0 CRYGS CRYAA
29 yemenite deaf-blind hypopigmentation syndrome 10.0
30 parotitis 10.0 MMP2 G6PD
31 disuse amblyopia 10.0 CRYGS CRYAA
32 central retinal vein occlusion 10.0 VEGFA SERPINF1 G6PD
33 laryngeal squamous cell carcinoma 10.0 VEGFA MMP2 MALAT1
34 vitreoretinopathy, neovascular inflammatory 10.0 VEGFA MALAT1 CRYAA
35 transient refractive change 10.0 SORD AKR1B1
36 retinal vascular disease 10.0 VEGFA SERPINF1 CRYAA AKR1B1
37 trimethoprim allergy 10.0 GSR G6PD
38 microvascular complications of diabetes 2 10.0
39 corneal edema 10.0
40 neuropathy 10.0
41 presbyopia 10.0 CRYGS CRYAA
42 exudative vitreoretinopathy 1 10.0 VEGFA SERPINF1 CRYAA
43 retinal perforation 9.9 VEGFA CRYGS CRYAA
44 intraocular pressure quantitative trait locus 9.9 VEGFA SERPINF1 MIR204 CRYAA
45 meningococcal infection 9.9 GSR G6PD
46 axenfeld-rieger syndrome, type 3 9.9 MIR204 CRYGS CRYAA
47 axenfeld-rieger syndrome 9.9 MIR204 CRYGS CRYAA
48 lymphosarcoma 9.9 GSR G6PD
49 eye accommodation disease 9.9 CRYGS CRYAA
50 retinal detachment 9.9 VEGFA SERPINF1 MMP2

Comorbidity relations with Diabetic Cataract via Phenotypic Disease Network (PDN):


Acute Cystitis Diabetic Polyneuropathy
Heart Disease Hypertension, Essential
Microvascular Complications of Diabetes 1 Microvascular Complications of Diabetes 7

Graphical network of the top 20 diseases related to Diabetic Cataract:



Diseases related to Diabetic Cataract

Symptoms & Phenotypes for Diabetic Cataract

Drugs & Therapeutics for Diabetic Cataract

Drugs for Diabetic Cataract (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
2 Antirheumatic Agents Phase 4
3 Anti-Inflammatory Agents Phase 4
4 Anti-Inflammatory Agents, Non-Steroidal Phase 4
5 Cyclooxygenase Inhibitors Phase 4
6 Analgesics, Non-Narcotic Phase 4
7 Analgesics Phase 4
8 Ketorolac Tromethamine Phase 4
9 Diminazene aceturate
10 Antiparasitic Agents
11 Antiprotozoal Agents
12 Anti-Infective Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Protein Profile of Immunoregulatory Factors in Diabetic Cataract Completed NCT01832311 Phase 4 Ketorolac
2 Safety of Trypan Blue Capsule Staining to Corneal Endothelium in Patients With Diabetic Retinopathy Completed NCT03755752

Search NIH Clinical Center for Diabetic Cataract

Genetic Tests for Diabetic Cataract

Anatomical Context for Diabetic Cataract

MalaCards organs/tissues related to Diabetic Cataract:

40
Eye, Cortex, Endothelial, Retina, Tongue, Kidney, Prostate

Publications for Diabetic Cataract

Articles related to Diabetic Cataract:

(show top 50) (show all 496)
# Title Authors PMID Year
1
Changes in erythrocyte glucose-6-phosphate dehydrogenase (G6PD) and reduced glutathione (GSH) activities in the development of senile and diabetic cataracts. 61 54
19058613 2008
2
Antioxidant markers in human senile and diabetic cataractous lenses. 54 61
17007750 2006
3
Role of anti-oxidant enzymes superoxide dismutase and catalase in the development of cataract : study of serum levels in patients with senile and diabetic cataracts. 54 61
17240813 2006
4
Correlation between adult diabetic cataracts and red blood cell aldose reductase levels. 54 61
16639016 2006
5
Alphab-crystallin-assisted reactivation of glucose-6-phosphate dehydrogenase upon refolding. 54 61
15952936 2005
6
Genetic analysis of aldose reductase in diabetic complications. 61 54
12871135 2003
7
Lens superoxide dismutase and catalase activities in diabetic cataract. 54 61
11937081 2002
8
[Magnetic resonance imaging study on rat sugar cataract]. 61 54
8256667 1993
9
[Aldose reductase: physiological role, properties and prospects for regulating activity]. 61 54
1344191 1992
10
[Quantitative study of rat diabetic cataract, by the relaxation times of nuclear magnetic resonance]. 54 61
1908617 1991
11
Polyol accumulation in cultured human lens epithelial cells. 61 54
1907924 1991
12
Glyceraldehyde-derived advanced glycation end-products having pyrrolopyridinium-based crosslinks. 61
33748437 2021
13
Resveratrol protects against high glucose-induced oxidative damage in human lens epithelial cells by activating autophagy. 61
33747177 2021
14
Expression of α-Klotho Is Downregulated and Associated with Oxidative Stress in the Lens in Streptozotocin-induced Diabetic Rats. 61
32744464 2021
15
Protective effect of syringic acid via restoring cells biomechanics and organelle structure in human lens epithelial cells. 61
33704647 2021
16
Changes of the tear film lipid layer thickness after cataract surgery in patients with diabetes mellitus. 61
32749786 2021
17
Orai3 exacerbates apoptosis of lens epithelial cells by disrupting Ca2+ homeostasis in diabetic cataract. 61
33784009 2021
18
Biochemical Evidence Indicates the Preventive Effect of Resveratrol and Nicotinamide in the Treatment of STZ-induced Diabetic Cataract. 61
32631099 2021
19
New Highlights of Resveratrol: A Review of Properties against Ocular Diseases. 61
33525499 2021
20
The Association Between Trace Elements and Osmolality in Plasma and Aqueous Humor Fluid in Diabetic Rabbits. 61
33409916 2021
21
Topical nerve growth factor attenuates streptozotocin-induced diabetic cataracts via polyol pathway inhibition and Na+/K+-ATPase upregulation. 61
33080303 2021
22
Repression of Polyol Pathway Activity by Hemidesmus indicus var. pubescens R.Br. Linn Root Extract, an Aldose Reductase Inhibitor: An In Silico and Ex Vivo Study. 61
33284412 2020
23
microRNA-199a-5p regulates epithelial-to-mesenchymal transition in diabetic cataract by targeting SP1 gene. 61
33276722 2020
24
Status of oxidative stress markers, advanced glycation index, and polyol pathway in age-related cataract subjects with and without diabetes. 61
32931824 2020
25
LncRNA KCNQ1OT1 knockdown inhibits viability, migration and epithelial-mesenchymal transition in human lens epithelial cells via miR-26a-5p/ITGAV/TGF-beta/Smad3 axis. 61
32950535 2020
26
Activation of autophagy inhibits epithelial to mesenchymal transition process of human lens epithelial cells induced by high glucose conditions. 61
32896607 2020
27
Mapping glucose metabolites in the normal bovine lens: Evaluation and optimisation of a matrix-assisted laser desorption/ionisation imaging mass spectrometry method. 61
33089566 2020
28
Association of Serum Magnesium with Oxidative Stress in the Pathogenesis of Diabetic Cataract. 61
33037494 2020
29
Activation of Sirtuin1 by lyceum barbarum polysaccharides in protection against diabetic cataract. 61
32730875 2020
30
Anticataract effects of S. cumini and A. marmelos on goat lenses in an experimental diabetic cataract model. 61
32111448 2020
31
Profiling of circular RNAs in age-related cataract reveals circZNF292 as an antioxidant by sponging miR-23b-3p. 61
32913142 2020
32
Quercetin inhibits AQP1 translocation in high-glucose-cultured SRA01/04 cells through PI3K/Akt/mTOR Pathway. 61
32900356 2020
33
Klotho ameliorates the onset and progression of cataract via suppressing oxidative stress and inflammation in the lens in streptozotocin-induced diabetic rats. 61
32438076 2020
34
Cyanidin-3-O-glucoside Protects Lens Epithelial Cells against High Glucose-Induced Apoptosis and Prevents Cataract Formation via Suppressing NF-κB Activation and Cox-2 Expression. 61
32640796 2020
35
Identification of tRNA-derived fragments and their potential roles in diabetic cataract rats. 61
32700969 2020
36
Citrus hystrix leaf extract attenuated diabetic-cataract in STZ-rats. 61
32539198 2020
37
The potential health benefits of dietary natural plant products in age related eye diseases. 61
32685729 2020
38
Substituted 2-thioxothiazolidin-4-one derivatives showed protective effects against diabetic cataract via inhibition of aldose reductase. 61
32237167 2020
39
N6-Methyladenosine METTL3 Modulates the Proliferation and Apoptosis of Lens Epithelial Cells in Diabetic Cataract. 61
32163892 2020
40
Role of lncRNA NEAT1 mediated by YY1 in the development of diabetic cataract via targeting the microRNA-205-3p/MMP16 axis. 61
32572898 2020
41
AKR1B1-Induced Epithelial-Mesenchymal Transition Mediated by RAGE-Oxidative Stress in Diabetic Cataract Lens. 61
32218152 2020
42
Concentrations of Selected Cytokines and Vascular Endothelial Growth Factor in Aqueous Humor and Serum of Diabetic Patients. 61
32310727 2020
43
SP1-mediated lncRNA PVT1 modulates the proliferation and apoptosis of lens epithelial cells in diabetic cataract via miR-214-3p/MMP2 axis. 61
31755246 2020
44
Aqueous humor and serum 25-Hydroxyvitamin D levels in patients with cataracts. 61
31906919 2020
45
LncRNA MALAT1 Regulates miR-144-3p to Facilitate Epithelial-Mesenchymal Transition of Lens Epithelial Cells via the ROS/NRF2/Notch1/Snail Pathway. 61
33274006 2020
46
Choroidal Structural Changes Assessed with Swept-Source Optical Coherence Tomography after Cataract Surgery in Eyes with Diabetic Retinopathy. 61
33178452 2020
47
Diabetic Cataract in Spontaneously Diabetic Torii Fatty Rats. 61
32832559 2020
48
Decorin inhibits glucose-induced lens epithelial cell apoptosis via suppressing p22phox-p38 MAPK signaling pathway. 61
32339204 2020
49
Histone acetyltransferase and Polo-like kinase 3 inhibitors prevent rat galactose-induced cataract. 61
31882756 2019
50
Vitamin K1 prevents diabetic cataract by inhibiting lens aldose reductase 2 (ALR2) activity. 61
31604989 2019

Variations for Diabetic Cataract

Expression for Diabetic Cataract

Search GEO for disease gene expression data for Diabetic Cataract.

Pathways for Diabetic Cataract

Pathways related to Diabetic Cataract according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.75 VEGFA SP1 PPARD MMP2 AR
2 10.21 GSR G6PD

GO Terms for Diabetic Cataract

Biological processes related to Diabetic Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of inflammatory response GO:0050728 9.5 SERPINF1 PPARD MIR204
2 cellular response to hypoxia GO:0071456 9.43 VEGFA PPARD MALAT1
3 mammary gland alveolus development GO:0060749 9.16 VEGFA AR
4 glucose metabolic process GO:0006006 9.13 SORD PPARD G6PD
5 fructose biosynthetic process GO:0046370 8.62 SORD AKR1B1

Sources for Diabetic Cataract

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....