MCID: DBT007
MIFTS: 38

Diabetic Cataract

Categories: Eye diseases, Genetic diseases

Aliases & Classifications for Diabetic Cataract

MalaCards integrated aliases for Diabetic Cataract:

Name: Diabetic Cataract 12 56 15 74
Cataract - Diabetic 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13328
ICD9CM 36 366.41
SNOMED-CT 69 43959009
ICD10 34 H28.0
UMLS 74 C0011876

Summaries for Diabetic Cataract

MalaCards based summary : Diabetic Cataract, also known as cataract - diabetic, is related to microvascular complications of diabetes 5 and turner syndrome. An important gene associated with Diabetic Cataract is AKR1B1 (Aldo-Keto Reductase Family 1 Member B), and among its related pathways/superpathways are Pathways in cancer and HIF-1-alpha transcription factor network. The drugs Ketorolac and Analgesics have been mentioned in the context of this disorder. Affiliated tissues include eye and endothelial, and related phenotypes are homeostasis/metabolism and mortality/aging

Related Diseases for Diabetic Cataract

Diseases related to Diabetic Cataract via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)
# Related Disease Score Top Affiliating Genes
1 microvascular complications of diabetes 5 29.6 AKR1B1 SERPINF1 VEGFA
2 turner syndrome 11.0
3 premature aging syndrome, okamoto type 11.0
4 cataract 10.8
5 macular dystrophy, dominant cystoid 10.2 SERPINF1 VEGFA
6 central retinal vein occlusion 10.2 SERPINF1 VEGFA
7 diabetic polyneuropathy 10.1 AKR1B1 VEGFA
8 retinal vein occlusion 10.1 SERPINF1 VEGFA
9 macular holes 10.1 SERPINF1 VEGFA
10 diabetic macular edema 10.1 SERPINF1 VEGFA
11 lens disease 10.1 AKR1B1 VEGFA
12 corneal neovascularization 10.0 SERPINF1 VEGFA
13 diabetes mellitus 10.0
14 diabetic neuropathy 10.0 AKR1B1 VEGFA
15 retinal vascular disease 10.0 AKR1B1 SERPINF1 VEGFA
16 retinal ischemia 10.0 CAT VEGFA
17 microvascular complications of diabetes 1 10.0 AKR1B1 SERPINF1 VEGFA
18 diabetic angiopathy 10.0 CAT NOS2
19 hepatopulmonary syndrome 10.0 NOS2 VEGFA
20 eales disease 9.9 NOS2 SERPINF1 VEGFA
21 neuropathy 9.9
22 hyperphenylalaninemia 9.9 CACNA1C CAT
23 vascular disease 9.8 CAT NOS2 VEGFA
24 senile cataract 9.7
25 diabetes mellitus, noninsulin-dependent 9.7
26 aging 9.7
27 yemenite deaf-blind hypopigmentation syndrome 9.7
28 hyperglycemia 9.7
29 macular retinal edema 9.7
30 fibrocalculous pancreatopathy 9.7
31 osteoporosis 9.6
32 macular degeneration, age-related, 1 9.6
33 open-angle glaucoma 9.6
34 trachoma 9.6
35 male reproductive organ cancer 9.5 AR VEGFA

Comorbidity relations with Diabetic Cataract via Phenotypic Disease Network (PDN):


Acute Cystitis Diabetic Polyneuropathy
Heart Disease Hypertension, Essential
Microvascular Complications of Diabetes 1 Microvascular Complications of Diabetes 7

Graphical network of the top 20 diseases related to Diabetic Cataract:



Diseases related to Diabetic Cataract

Symptoms & Phenotypes for Diabetic Cataract

MGI Mouse Phenotypes related to Diabetic Cataract:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.95 AKR1B1 AR CACNA1C CAT NOS2 PPARD
2 mortality/aging MP:0010768 9.87 AKR1B1 AR CACNA1C CAT NOS2 PPARD
3 digestive/alimentary MP:0005381 9.83 AR NOS2 PPARD SERPINF1 VEGFA
4 integument MP:0010771 9.77 AR CACNA1C NOS2 PPARD VEGFA
5 muscle MP:0005369 9.65 AR CACNA1C NOS2 PPARD VEGFA
6 neoplasm MP:0002006 9.55 AR CAT NOS2 PPARD VEGFA
7 reproductive system MP:0005389 9.43 AR CACNA1C NOS2 PPARD SERPINF1 VEGFA
8 skeleton MP:0005390 9.1 AKR1B1 AR NOS2 PPARD SERPINF1 VEGFA

Drugs & Therapeutics for Diabetic Cataract

Drugs for Diabetic Cataract (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
2 Analgesics Phase 4
3 Anti-Inflammatory Agents Phase 4
4 Antirheumatic Agents Phase 4
5 Peripheral Nervous System Agents Phase 4
6 Anti-Inflammatory Agents, Non-Steroidal Phase 4
7 Cyclooxygenase Inhibitors Phase 4
8 Ketorolac Tromethamine Phase 4
9 Analgesics, Non-Narcotic Phase 4
10
Diminazene Experimental Not Applicable 536-71-0
11 Anti-Infective Agents Not Applicable
12 Antiparasitic Agents Not Applicable
13 Diminazene aceturate Not Applicable
14 Antiprotozoal Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Protein Profile of Immunoregulatory Factors in Diabetic Cataract Completed NCT01832311 Phase 4 Ketorolac
2 Safety of Trypan Blue on Endothelium of Diabetic Retinopathy Patients Completed NCT03755752 Not Applicable

Search NIH Clinical Center for Diabetic Cataract

Genetic Tests for Diabetic Cataract

Anatomical Context for Diabetic Cataract

MalaCards organs/tissues related to Diabetic Cataract:

42
Eye, Endothelial

Publications for Diabetic Cataract

Articles related to Diabetic Cataract:

(show top 50) (show all 121)
# Title Authors Year
1
Protective effect of glycine in streptozotocin-induced diabetic cataract through aldose reductase inhibitory activity. ( 30947017 )
2019
2
Investigation of expression and effects of TGF-β1 and MMP-9 in lens epithelial cells of diabetic cataract rats. ( 31086584 )
2019
3
Correlations of insulin resistance and HbA1c with cytokines IGF-1, bFGF and IL-6 in the aqueous humor of patients with diabetic cataract. ( 30657541 )
2019
4
Dietary flavonoids inhibit the glycation of lens proteins: implications in the management of diabetic cataract. ( 30729071 )
2019
5
Zinc Supplementation Ameliorates Diabetic Cataract Through Modulation of Crystallin Proteins and Polyol Pathway in Experimental Rats. ( 29756175 )
2019
6
Effect of Phacoemulsification Combined with Intraocular Lens Implantation on Inflammatory Factors, Oxidative Stress Response and Hemorheology in Diabetic Cataract Patients. ( 30266120 )
2018
7
Expression levels of aldose reductase enzyme, vascular endothelial growth factor, and intercellular adhesion molecule-1 in the anterior lens capsule of diabetic cataract patients. ( 30274845 )
2018
8
LncRNA MALAT1 promotes the apoptosis and oxidative stress of human lens epithelial cells via p38MAPK pathway in diabetic cataract. ( 29936249 )
2018
9
Markers of poor glycemic control are helpful to assess the risk of pseudophakic macular edema in diabetic cataract surgery patients. ( 29703307 )
2018
10
Ursodeoxycholic acid suppresses the formation of fructose/streptozotocin-induced diabetic cataract in rats. ( 29863796 )
2018
11
Effect of Oral Alpha Lipoic Acid in Preventing the Genesis of Canine Diabetic Cataract: A Preliminary Study. ( 29056677 )
2017
12
Clinical evaluation of corneal changes after phacoemulsification in diabetic and non-diabetic cataract patients, a systematic review and meta-analysis. ( 29074989 )
2017
13
MiR-30a inhibits BECN1-mediated autophagy in diabetic cataract. ( 29100392 )
2017
14
Effects of microRNA-211 on proliferation and apoptosis of lens epithelial cells by targeting SIRT1 gene in diabetic cataract mice. ( 28679650 )
2017
15
Potential of CeCl3@mSiO2 nanoparticles in alleviating diabetic cataract development and progression. ( 28065730 )
2017
16
Interaction of AR and iNOS in lens epithelial cell: A new pathogenesis and potential therapeutic targets of diabetic cataract. ( 28108234 )
2017
17
Does oxidative stress play any role in diabetic cataract formation? ----Re-evaluation using a thioltransferase gene knockout mouse model. ( 28579033 )
2017
18
Protective effect of Tephrosia purpurea in diabetic cataract through aldose reductase inhibitory activity. ( 27372406 )
2016
19
Structure-Activity Relationship Study Reveals Benzazepine Derivatives of Luteolin as New Aldose Reductase Inhibitors for Diabetic Cataract. ( 27396410 )
2016
20
A Genome-Wide Association Study Provides New Evidence That CACNA1C Gene is Associated With Diabetic Cataract. ( 27124316 )
2016
21
Characterization of Emodin as a Therapeutic Agent for Diabetic Cataract. ( 27140653 )
2016
22
Inhibitory Effect of Crocin(s) on Lens α-Crystallin Glycation and Aggregation, Results in the Decrease of the Risk of Diabetic Cataract. ( 26821002 )
2016
23
Featured Article: Inhibition of diabetic cataract by glucose tolerance factor extracted from yeast. ( 26825353 )
2016
24
Levels of Selected Aqueous Humor Mediators (IL-10, IL-17, CCL2, VEGF, FasL) in Diabetic Cataract. ( 25314260 )
2016
25
DL-3-n-butylphthalide delays the onset and progression of diabetic cataract by inhibiting oxidative stress in rat diabetic model. ( 26759189 )
2016
26
Investigation of synergistic mechanism and identification of interaction site of aldose reductase with the combination of gigantol and syringic acid for prevention of diabetic cataract. ( 27520089 )
2016
27
Synthesis and Biological Evaluation of Novel Gigantol Derivatives as Potential Agents in Prevention of Diabetic Cataract. ( 26517726 )
2015
28
Corneal Bullous Epithelial Detachment in Diabetic Cataract Surgery. ( 26002007 )
2015
29
Protective effect of resveratrol on lens epithelial cell apoptosis in diabetic cataract rat. ( 25902031 )
2015
30
Grape seed extract and Zinc containing nutritional food supplement delays onset and progression of Streptozocin-induced diabetic cataract in Wistar rats. ( 25892780 )
2015
31
Effects of two antioxidants; α-lipoic acid and fisetin against diabetic cataract in mice. ( 25488016 )
2015
32
Differential Protein Expression between Type 1 Diabetic Cataract and Age-Related Cataract Patients. ( 26333124 )
2015
33
Inhibition of diabetic-cataract by vitamin K1 involves modulation of hyperglycemia-induced alterations to lens calcium homeostasis. ( 25257692 )
2014
34
Expression of p53 and caspase-8 in lens epithelial cells of diabetic cataract. ( 24957431 )
2014
35
Retraction. Activation of aldose reductase by interaction with tubulin and involvement of this mechanism in diabetic cataract formation. Diabetes. 10 April 2014 [Epub ahead of print]. DOI: 10.2337/db13-1265. ( 24722247 )
2014
36
Preventive effect of Zea mays L. (purple waxy corn) on experimental diabetic cataract. ( 24527449 )
2014
37
Incidence of visual impairment due to cataract, diabetic retinopathy and trachoma in indigenous Australians within central Australia: the Central Australian Ocular Health Study. ( 22594763 )
2013
38
Inhibition of protein glycation by procyanidin-B2 enriched fraction of cinnamon: delay of diabetic cataract in rats. ( 24136906 )
2013
39
Inhibition of aldose reductase by Aegle marmelos and its protective role in diabetic cataract. ( 23827758 )
2013
40
Early phacoemulsification in diabetic cataract for early recognition and management of diabetic macular oedema. ( 23763799 )
2013
41
Effects of long-term treatment with ranirestat, a potent aldose reductase inhibitor, on diabetic cataract and neuropathy in spontaneously diabetic torii rats. ( 23671855 )
2013
42
Novel susceptibility genes associated with diabetic cataract in a Taiwanese population. ( 23137000 )
2013
43
Syringic Acid Extracted from Herba dendrobii Prevents Diabetic Cataract Pathogenesis by Inhibiting Aldose Reductase Activity. ( 23365598 )
2012
44
GP-1447, an inhibitor of aldose reductase, prevents the progression of diabetic cataract in rats. ( 22687477 )
2012
45
Na+/H+-exchanger-1 inhibition counteracts diabetic cataract formation and retinal oxidative-nitrative stress and apoptosis. ( 22407349 )
2012
46
Natural flavonoids as potential multifunctional agents in prevention of diabetic cataract. ( 21753902 )
2011
47
Topical metal chelation therapy ameliorates oxidation-induced toxicity in diabetic cataract. ( 21271438 )
2011
48
Relationship between Pentosidine and Pyridinoline Levels in Human Diabetic Cataract Lenses. ( 21103032 )
2010
49
Antiglycating potential of Zingiber officinalis and delay of diabetic cataract in rats. ( 20806076 )
2010
50
Diabetic cataract-pathogenesis, epidemiology and treatment. ( 20634936 )
2010

Variations for Diabetic Cataract

Expression for Diabetic Cataract

Search GEO for disease gene expression data for Diabetic Cataract.

Pathways for Diabetic Cataract

GO Terms for Diabetic Cataract

Cellular components related to Diabetic Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peroxisomal matrix GO:0005782 8.62 CAT NOS2

Biological processes related to Diabetic Cataract according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 cell proliferation GO:0008283 9.71 AR PPARD SERPINF1
2 negative regulation of apoptotic process GO:0043066 9.62 AKR1B1 CAT PPARD VEGFA
3 negative regulation of gene expression GO:0010629 9.54 NOS2 SERPINF1 VEGFA
4 regulation of insulin secretion GO:0050796 9.52 CACNA1C NOS2
5 protein targeting to peroxisome GO:0006625 9.51 CAT NOS2
6 negative regulation of epithelial cell proliferation GO:0050680 9.49 AR PPARD
7 steroid hormone mediated signaling pathway GO:0043401 9.48 AR PPARD
8 positive regulation of cell division GO:0051781 9.46 CAT VEGFA
9 response to activity GO:0014823 9.43 CAT PPARD
10 response to hypoxia GO:0001666 9.43 CAT NOS2 VEGFA
11 intracellular receptor signaling pathway GO:0030522 9.4 AR PPARD
12 response to vitamin A GO:0033189 9.16 CAT PPARD
13 mammary gland alveolus development GO:0060749 8.96 AR VEGFA
14 kidney development GO:0001822 8.8 CAT SERPINF1 VEGFA

Molecular functions related to Diabetic Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid hormone receptor activity GO:0003707 9.16 AR PPARD
2 nuclear receptor activity GO:0004879 8.96 AR PPARD
3 NADP binding GO:0050661 8.62 CAT NOS2

Sources for Diabetic Cataract

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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