Aliases & Classifications for Diabetic Cataract

MalaCards integrated aliases for Diabetic Cataract:

Name: Diabetic Cataract 12 55 15 73
Cataract - Diabetic 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13328
ICD9CM 35 366.41
ICD10 33 H28.0
UMLS 73 C0011876

Summaries for Diabetic Cataract

MalaCards based summary : Diabetic Cataract, also known as cataract - diabetic, is related to macular retinal edema and turner syndrome. An important gene associated with Diabetic Cataract is AKR1B1 (Aldo-Keto Reductase Family 1 Member B), and among its related pathways/superpathways is Celecoxib Pathway, Pharmacodynamics. The drugs Ketorolac and Analgesics have been mentioned in the context of this disorder. Affiliated tissues include eye, and related phenotype is neoplasm.

Related Diseases for Diabetic Cataract

Graphical network of the top 20 diseases related to Diabetic Cataract:



Diseases related to Diabetic Cataract

Symptoms & Phenotypes for Diabetic Cataract

MGI Mouse Phenotypes related to Diabetic Cataract:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.92 AR CAT PPARD VEGFA

Drugs & Therapeutics for Diabetic Cataract

Drugs for Diabetic Cataract (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
2 Analgesics Phase 4
3 Analgesics, Non-Narcotic Phase 4
4 Anti-Inflammatory Agents Phase 4
5 Anti-Inflammatory Agents, Non-Steroidal Phase 4
6 Antirheumatic Agents Phase 4
7 Cyclooxygenase Inhibitors Phase 4
8 Ketorolac Tromethamine Phase 4
9 Peripheral Nervous System Agents Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Protein Profile of Immunoregulatory Factors in Diabetic Cataract Completed NCT01832311 Phase 4 Ketorolac

Search NIH Clinical Center for Diabetic Cataract

Genetic Tests for Diabetic Cataract

Anatomical Context for Diabetic Cataract

MalaCards organs/tissues related to Diabetic Cataract:

41
Eye

Publications for Diabetic Cataract

Articles related to Diabetic Cataract:

(show top 50) (show all 121)
# Title Authors Year
1
Ursodeoxycholic acid suppresses the formation of fructose/streptozotocin-induced diabetic cataract in rats. ( 29863796 )
2018
2
Zinc Supplementation Ameliorates Diabetic Cataract Through Modulation of Crystallin Proteins and Polyol Pathway in Experimental Rats. ( 29756175 )
2018
3
Markers of poor glycemic control are helpful to assess the risk of pseudophakic macular edema in diabetic cataract surgery patients. ( 29703307 )
2018
4
LncRNA MALAT1 promotes the apoptosis and oxidative stress of human lens epithelial cells via p38MAPK pathway in diabetic cataract. ( 29936249 )
2018
5
Nrf2 as a target for prevention of age-related and diabetic cataracts by against oxidative stress. ( 28722304 )
2017
6
Clinical evaluation of corneal changes after phacoemulsification in diabetic and non-diabetic cataract patients, a systematic review and meta-analysis. ( 29074989 )
2017
7
Interaction of AR and iNOS in lens epithelial cell: A new pathogenesis and potential therapeutic targets of diabetic cataract. ( 28108234 )
2017
8
Potential of CeCl3@mSiO2 nanoparticles in alleviating diabetic cataract development and progression. ( 28065730 )
2017
9
Does oxidative stress play any role in diabetic cataract formation? ----Re-evaluation using a thioltransferase gene knockout mouse model. ( 28579033 )
2017
10
Effects of microRNA-211 on proliferation and apoptosis of lens epithelial cells by targeting SIRT1 gene in diabetic cataract mice. ( 28679650 )
2017
11
MiR-30a inhibits BECN1-mediated autophagy in diabetic cataract. ( 29100392 )
2017
12
Effect of Oral Alpha Lipoic Acid in Preventing the Genesis of Canine Diabetic Cataract: A Preliminary Study. ( 29056677 )
2017
13
Characterization of Emodin as a Therapeutic Agent for Diabetic Cataract. ( 27140653 )
2016
14
Calpain and Caspase-12 Expression in Lens Epithelial Cells of Diabetic Cataracts. ( 27130368 )
2016
15
DL-3-n-butylphthalide delays the onset and progression of diabetic cataract by inhibiting oxidative stress in rat diabetic model. ( 26759189 )
2016
16
Investigation of synergistic mechanism and identification of interaction site of aldose reductase with the combination of gigantol and syringic acid for prevention of diabetic cataract. ( 27520089 )
2016
17
A Genome-Wide Association Study Provides New Evidence That CACNA1C Gene is Associated With Diabetic Cataract. ( 27124316 )
2016
18
Inhibitory Effect of Crocin(s) on Lens I+-Crystallin Glycation and Aggregation, Results in the Decrease of the Risk of Diabetic Cataract. ( 26821002 )
2016
19
Featured Article: Inhibition of diabetic cataract by glucose tolerance factor extracted from yeast. ( 26825353 )
2016
20
Protective effect of Tephrosia purpurea in diabetic cataract through aldose reductase inhibitory activity. ( 27372406 )
2016
21
Structure-Activity Relationship Study Reveals Benzazepine Derivatives of Luteolin as New Aldose Reductase Inhibitors for Diabetic Cataract. ( 27396410 )
2016
22
Differential Protein Expression between Type 1 Diabetic Cataract and Age-Related Cataract Patients. ( 26333124 )
2015
23
Protective effect of resveratrol on lens epithelial cell apoptosis in diabetic cataract rat. ( 25902031 )
2015
24
Grape seed extract and Zinc containing nutritional food supplement delays onset and progression of Streptozocin-induced diabetic cataract in Wistar rats. ( 25892780 )
2015
25
Corneal Bullous Epithelial Detachment in Diabetic Cataract Surgery. ( 26002007 )
2015
26
Synthesis and Biological Evaluation of Novel Gigantol Derivatives as Potential Agents in Prevention of Diabetic Cataract. ( 26517726 )
2015
27
Inhibition of diabetic-cataract by vitamin K1 involves modulation of hyperglycemia-induced alterations to lens calcium homeostasis. ( 25257692 )
2014
28
Preventive effect of Zea mays L. (purple waxy corn) on experimental diabetic cataract. ( 24527449 )
2014
29
Levels of Selected Aqueous Humor Mediators (IL-10, IL-17, CCL2, VEGF, FasL) in Diabetic Cataract. ( 25314260 )
2014
30
Effects of two antioxidants; I+-lipoic acid and fisetin against diabetic cataract in mice. ( 25488016 )
2014
31
Expression of p53 and caspase-8 in lens epithelial cells of diabetic cataract. ( 24957431 )
2014
32
Retraction. Activation of aldose reductase by interaction with tubulin and involvement of this mechanism in diabetic cataract formation. Diabetes. 10 April 2014 [Epub ahead of print]. DOI: 10.2337/db13-1265. ( 24722247 )
2014
33
Inhibition of aldose reductase by Aegle marmelos and its protective role in diabetic cataract. ( 23827758 )
2013
34
Effects of long-term treatment with ranirestat, a potent aldose reductase inhibitor, on diabetic cataract and neuropathy in spontaneously diabetic torii rats. ( 23671855 )
2013
35
Inhibition of protein glycation by procyanidin-B2 enriched fraction of cinnamon: delay of diabetic cataract in rats. ( 24136906 )
2013
36
Early phacoemulsification in diabetic cataract for early recognition and management of diabetic macular oedema. ( 23763799 )
2013
37
Novel susceptibility genes associated with diabetic cataract in a Taiwanese population. ( 23137000 )
2013
38
Promoter demethylation of Keap1 gene in human diabetic cataractous lenses. ( 22683333 )
2012
39
Syringic Acid Extracted from Herba dendrobii Prevents Diabetic Cataract Pathogenesis by Inhibiting Aldose Reductase Activity. ( 23365598 )
2012
40
GP-1447, an inhibitor of aldose reductase, prevents the progression of diabetic cataract in rats. ( 22687477 )
2012
41
Na+/H+-exchanger-1 inhibition counteracts diabetic cataract formation and retinal oxidative-nitrative stress and apoptosis. ( 22407349 )
2012
42
Natural flavonoids as potential multifunctional agents in prevention of diabetic cataract. ( 21753902 )
2011
43
Topical metal chelation therapy ameliorates oxidation-induced toxicity in diabetic cataract. ( 21271438 )
2011
44
Diabetic cataract-pathogenesis, epidemiology and treatment. ( 20634936 )
2010
45
Relationship between Pentosidine and Pyridinoline Levels in Human Diabetic Cataract Lenses. ( 21103032 )
2010
46
Antiglycating potential of Zingiber officinalis and delay of diabetic cataract in rats. ( 20806076 )
2010
47
Delay of diabetic cataract in rats by the antiglycating potential of cumin through modulation of alpha-crystallin chaperone activity. ( 18789666 )
2009
48
Elevated Expression of indoleamine 2,3-dioxygenase (IDO) and accumulation of kynurenic acid in the pathogenesis of STZ-induced diabetic cataract in Wistar rats. ( 19373575 )
2009
49
Effect of a combination of carnosine and aspirin eye drops on streptozotocin -- induced diabetic cataract in rats. ( 19898641 )
2009
50
Influence of selected angiotensin-converting enzyme inhibitors on alloxan-induced diabetic cataract in rabbits. ( 19865050 )
2009

Variations for Diabetic Cataract

Expression for Diabetic Cataract

Search GEO for disease gene expression data for Diabetic Cataract.

Pathways for Diabetic Cataract

Pathways related to Diabetic Cataract according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.39 CACNA1C VEGFA

GO Terms for Diabetic Cataract

Biological processes related to Diabetic Cataract according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.69 AR PPARD VEGFA
2 cell proliferation GO:0008283 9.67 AR PPARD SERPINF1
3 negative regulation of apoptotic process GO:0043066 9.56 AKR1B1 CAT PPARD VEGFA
4 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.48 CAT PPARD
5 negative regulation of epithelial cell proliferation GO:0050680 9.46 AR PPARD
6 steroid hormone mediated signaling pathway GO:0043401 9.43 AR PPARD
7 positive regulation of cell division GO:0051781 9.4 CAT VEGFA
8 intracellular receptor signaling pathway GO:0030522 9.37 AR PPARD
9 response to activity GO:0014823 9.32 CAT PPARD
10 response to vitamin A GO:0033189 9.16 CAT PPARD
11 mammary gland alveolus development GO:0060749 8.96 AR VEGFA
12 kidney development GO:0001822 8.8 CAT SERPINF1 VEGFA

Molecular functions related to Diabetic Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid hormone receptor activity GO:0003707 8.96 AR PPARD
2 nuclear receptor activity GO:0004879 8.62 AR PPARD

Sources for Diabetic Cataract

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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