MCID: DBT007
MIFTS: 35

Diabetic Cataract

Categories: Eye diseases, Genetic diseases

Aliases & Classifications for Diabetic Cataract

MalaCards integrated aliases for Diabetic Cataract:

Name: Diabetic Cataract 12 55 15 73
Cataract - Diabetic 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13328
ICD9CM 35 366.41
SNOMED-CT 68 43959009
ICD10 33 H28.0
UMLS 73 C0011876

Summaries for Diabetic Cataract

MalaCards based summary : Diabetic Cataract, also known as cataract - diabetic, is related to microvascular complications of diabetes 5 and turner syndrome. An important gene associated with Diabetic Cataract is AKR1B1 (Aldo-Keto Reductase Family 1 Member B), and among its related pathways/superpathways is Celecoxib Pathway, Pharmacodynamics. The drugs Ketorolac and Ketorolac Tromethamine have been mentioned in the context of this disorder. Affiliated tissues include eye, heart and endothelial, and related phenotype is neoplasm.

Related Diseases for Diabetic Cataract

Diseases related to Diabetic Cataract via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 34)
# Related Disease Score Top Affiliating Genes
1 microvascular complications of diabetes 5 29.6 AKR1B1 SERPINF1 VEGFA
2 turner syndrome 11.0
3 premature aging syndrome, okamoto type 10.9
4 cataract 10.8
5 macular dystrophy, dominant cystoid 10.1 SERPINF1 VEGFA
6 central retinal vein occlusion 10.1 SERPINF1 VEGFA
7 diabetic polyneuropathy 10.1 AKR1B1 VEGFA
8 retinal vein occlusion 10.1 SERPINF1 VEGFA
9 eales disease 10.1 SERPINF1 VEGFA
10 lymphangioma 10.1 SERPINF1 VEGFA
11 macular holes 10.1 SERPINF1 VEGFA
12 diabetic macular edema 10.1 SERPINF1 VEGFA
13 corneal neovascularization 10.1 SERPINF1 VEGFA
14 diabetic neuropathy 10.1 AKR1B1 VEGFA
15 retinal ischemia 10.0 CAT VEGFA
16 hyperphenylalaninemia 10.0 CACNA1C CAT
17 retinal vascular disease 10.0 AKR1B1 SERPINF1 VEGFA
18 microvascular complications of diabetes 1 10.0 AKR1B1 SERPINF1 VEGFA
19 retinal detachment 10.0 SERPINF1 VEGFA
20 male reproductive organ cancer 10.0 AR VEGFA
21 male reproductive system disease 9.9 AR VEGFA
22 neuropathy 9.9
23 lens disease 9.8 AKR1B1 GBA3 VEGFA
24 gonadal disease 9.8 AR VEGFA
25 diabetes mellitus 9.7
26 hyperglycemia 9.7
27 macular retinal edema 9.7
28 juvenile rheumatoid arthritis 9.7
29 fibrocalculous pancreatopathy 9.7
30 macular degeneration, age-related, 1 9.6
31 open-angle glaucoma 9.6
32 trachoma 9.6
33 kidney disease 9.6
34 senile cataract 9.6

Comorbidity relations with Diabetic Cataract via Phenotypic Disease Network (PDN):


Acute Cystitis Diabetic Polyneuropathy
Heart Disease Hypertension, Essential
Microvascular Complications of Diabetes 1 Microvascular Complications of Diabetes 7

Graphical network of the top 20 diseases related to Diabetic Cataract:



Diseases related to Diabetic Cataract

Symptoms & Phenotypes for Diabetic Cataract

MGI Mouse Phenotypes related to Diabetic Cataract:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.92 AR CAT PPARD VEGFA

Drugs & Therapeutics for Diabetic Cataract

Drugs for Diabetic Cataract (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
2 Ketorolac Tromethamine Phase 4
3 Analgesics Phase 4
4 Anti-Inflammatory Agents, Non-Steroidal Phase 4
5 Anti-Inflammatory Agents Phase 4
6 Analgesics, Non-Narcotic Phase 4
7 Peripheral Nervous System Agents Phase 4
8 Antirheumatic Agents Phase 4
9 Cyclooxygenase Inhibitors Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Protein Profile of Immunoregulatory Factors in Diabetic Cataract Completed NCT01832311 Phase 4 Ketorolac
2 Safety of Trypan Blue on Endothelium of Diabetic Retinopathy Patients Completed NCT03755752 Not Applicable

Search NIH Clinical Center for Diabetic Cataract

Genetic Tests for Diabetic Cataract

Anatomical Context for Diabetic Cataract

MalaCards organs/tissues related to Diabetic Cataract:

41
Eye, Heart, Endothelial, Kidney

Publications for Diabetic Cataract

Articles related to Diabetic Cataract:

(show top 50) (show all 115)
# Title Authors Year
1
Ursodeoxycholic acid suppresses the formation of fructose/streptozotocin-induced diabetic cataract in rats. ( 29863796 )
2018
2
Zinc Supplementation Ameliorates Diabetic Cataract Through Modulation of Crystallin Proteins and Polyol Pathway in Experimental Rats. ( 29756175 )
2018
3
Markers of poor glycemic control are helpful to assess the risk of pseudophakic macular edema in diabetic cataract surgery patients. ( 29703307 )
2018
4
LncRNA MALAT1 promotes the apoptosis and oxidative stress of human lens epithelial cells via p38MAPK pathway in diabetic cataract. ( 29936249 )
2018
5
Effect of Phacoemulsification Combined with Intraocular Lens Implantation on Inflammatory Factors, Oxidative Stress Response and Hemorheology in Diabetic Cataract Patients. ( 30266120 )
2018
6
Expression levels of aldose reductase enzyme, vascular endothelial growth factor, and intercellular adhesion molecule-1 in the anterior lens capsule of diabetic cataract patients. ( 30274845 )
2018
7
Clinical evaluation of corneal changes after phacoemulsification in diabetic and non-diabetic cataract patients, a systematic review and meta-analysis. ( 29074989 )
2017
8
Interaction of AR and iNOS in lens epithelial cell: A new pathogenesis and potential therapeutic targets of diabetic cataract. ( 28108234 )
2017
9
Potential of CeCl3@mSiO2 nanoparticles in alleviating diabetic cataract development and progression. ( 28065730 )
2017
10
Does oxidative stress play any role in diabetic cataract formation? ----Re-evaluation using a thioltransferase gene knockout mouse model. ( 28579033 )
2017
11
Effects of microRNA-211 on proliferation and apoptosis of lens epithelial cells by targeting SIRT1 gene in diabetic cataract mice. ( 28679650 )
2017
12
MiR-30a inhibits BECN1-mediated autophagy in diabetic cataract. ( 29100392 )
2017
13
Effect of Oral Alpha Lipoic Acid in Preventing the Genesis of Canine Diabetic Cataract: A Preliminary Study. ( 29056677 )
2017
14
Characterization of Emodin as a Therapeutic Agent for Diabetic Cataract. ( 27140653 )
2016
15
DL-3-n-butylphthalide delays the onset and progression of diabetic cataract by inhibiting oxidative stress in rat diabetic model. ( 26759189 )
2016
16
Investigation of synergistic mechanism and identification of interaction site of aldose reductase with the combination of gigantol and syringic acid for prevention of diabetic cataract. ( 27520089 )
2016
17
A Genome-Wide Association Study Provides New Evidence That CACNA1C Gene is Associated With Diabetic Cataract. ( 27124316 )
2016
18
Inhibitory Effect of Crocin(s) on Lens I+-Crystallin Glycation and Aggregation, Results in the Decrease of the Risk of Diabetic Cataract. ( 26821002 )
2016
19
Featured Article: Inhibition of diabetic cataract by glucose tolerance factor extracted from yeast. ( 26825353 )
2016
20
Protective effect of Tephrosia purpurea in diabetic cataract through aldose reductase inhibitory activity. ( 27372406 )
2016
21
Structure-Activity Relationship Study Reveals Benzazepine Derivatives of Luteolin as New Aldose Reductase Inhibitors for Diabetic Cataract. ( 27396410 )
2016
22
Differential Protein Expression between Type 1 Diabetic Cataract and Age-Related Cataract Patients. ( 26333124 )
2015
23
Protective effect of resveratrol on lens epithelial cell apoptosis in diabetic cataract rat. ( 25902031 )
2015
24
Grape seed extract and Zinc containing nutritional food supplement delays onset and progression of Streptozocin-induced diabetic cataract in Wistar rats. ( 25892780 )
2015
25
Corneal Bullous Epithelial Detachment in Diabetic Cataract Surgery. ( 26002007 )
2015
26
Synthesis and Biological Evaluation of Novel Gigantol Derivatives as Potential Agents in Prevention of Diabetic Cataract. ( 26517726 )
2015
27
Inhibition of diabetic-cataract by vitamin K1 involves modulation of hyperglycemia-induced alterations to lens calcium homeostasis. ( 25257692 )
2014
28
Preventive effect of Zea mays L. (purple waxy corn) on experimental diabetic cataract. ( 24527449 )
2014
29
Levels of Selected Aqueous Humor Mediators (IL-10, IL-17, CCL2, VEGF, FasL) in Diabetic Cataract. ( 25314260 )
2014
30
Effects of two antioxidants; I+-lipoic acid and fisetin against diabetic cataract in mice. ( 25488016 )
2014
31
Expression of p53 and caspase-8 in lens epithelial cells of diabetic cataract. ( 24957431 )
2014
32
Retraction. Activation of aldose reductase by interaction with tubulin and involvement of this mechanism in diabetic cataract formation. Diabetes. 10 April 2014 [Epub ahead of print]. DOI: 10.2337/db13-1265. ( 24722247 )
2014
33
Inhibition of aldose reductase by Aegle marmelos and its protective role in diabetic cataract. ( 23827758 )
2013
34
Effects of long-term treatment with ranirestat, a potent aldose reductase inhibitor, on diabetic cataract and neuropathy in spontaneously diabetic torii rats. ( 23671855 )
2013
35
Inhibition of protein glycation by procyanidin-B2 enriched fraction of cinnamon: delay of diabetic cataract in rats. ( 24136906 )
2013
36
Early phacoemulsification in diabetic cataract for early recognition and management of diabetic macular oedema. ( 23763799 )
2013
37
Novel susceptibility genes associated with diabetic cataract in a Taiwanese population. ( 23137000 )
2013
38
Syringic Acid Extracted from Herba dendrobii Prevents Diabetic Cataract Pathogenesis by Inhibiting Aldose Reductase Activity. ( 23365598 )
2012
39
GP-1447, an inhibitor of aldose reductase, prevents the progression of diabetic cataract in rats. ( 22687477 )
2012
40
Na+/H+-exchanger-1 inhibition counteracts diabetic cataract formation and retinal oxidative-nitrative stress and apoptosis. ( 22407349 )
2012
41
Natural flavonoids as potential multifunctional agents in prevention of diabetic cataract. ( 21753902 )
2011
42
Topical metal chelation therapy ameliorates oxidation-induced toxicity in diabetic cataract. ( 21271438 )
2011
43
Diabetic cataract-pathogenesis, epidemiology and treatment. ( 20634936 )
2010
44
Relationship between Pentosidine and Pyridinoline Levels in Human Diabetic Cataract Lenses. ( 21103032 )
2010
45
Antiglycating potential of Zingiber officinalis and delay of diabetic cataract in rats. ( 20806076 )
2010
46
Delay of diabetic cataract in rats by the antiglycating potential of cumin through modulation of alpha-crystallin chaperone activity. ( 18789666 )
2009
47
Elevated Expression of indoleamine 2,3-dioxygenase (IDO) and accumulation of kynurenic acid in the pathogenesis of STZ-induced diabetic cataract in Wistar rats. ( 19373575 )
2009
48
Effect of a combination of carnosine and aspirin eye drops on streptozotocin -- induced diabetic cataract in rats. ( 19898641 )
2009
49
Influence of selected angiotensin-converting enzyme inhibitors on alloxan-induced diabetic cataract in rabbits. ( 19865050 )
2009
50
Effects of N-acetylcysteine and glutathione ethyl ester drops on streptozotocin-induced diabetic cataract in rats. ( 18490958 )
2008

Variations for Diabetic Cataract

Expression for Diabetic Cataract

Search GEO for disease gene expression data for Diabetic Cataract.

Pathways for Diabetic Cataract

Pathways related to Diabetic Cataract according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.39 CACNA1C VEGFA

GO Terms for Diabetic Cataract

Biological processes related to Diabetic Cataract according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cell proliferation GO:0008283 9.65 AR PPARD SERPINF1
2 negative regulation of apoptotic process GO:0043066 9.56 AKR1B1 CAT PPARD VEGFA
3 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.49 CAT PPARD
4 negative regulation of epithelial cell proliferation GO:0050680 9.46 AR PPARD
5 steroid hormone mediated signaling pathway GO:0043401 9.43 AR PPARD
6 positive regulation of cell division GO:0051781 9.4 CAT VEGFA
7 response to activity GO:0014823 9.37 CAT PPARD
8 intracellular receptor signaling pathway GO:0030522 9.32 AR PPARD
9 response to vitamin A GO:0033189 9.16 CAT PPARD
10 mammary gland alveolus development GO:0060749 8.96 AR VEGFA
11 kidney development GO:0001822 8.8 CAT SERPINF1 VEGFA

Molecular functions related to Diabetic Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid hormone receptor activity GO:0003707 8.96 AR PPARD
2 nuclear receptor activity GO:0004879 8.62 AR PPARD

Sources for Diabetic Cataract

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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