MCID: DBT081
MIFTS: 27

Diabetic Encephalopathy

Categories: Neuronal diseases

Aliases & Classifications for Diabetic Encephalopathy

MalaCards integrated aliases for Diabetic Encephalopathy:

Name: Diabetic Encephalopathy 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050850

Summaries for Diabetic Encephalopathy

Disease Ontology : 12 A brain disease that is characterized by functional impairment of cognition, cerebral signal conduction, neurotransmission and synaptic plasticity, and underlying structural pathology associated with diabetes.

MalaCards based summary : Diabetic Encephalopathy is related to alzheimer disease and encephalopathy. An important gene associated with Diabetic Encephalopathy is CREB1 (CAMP Responsive Element Binding Protein 1), and among its related pathways/superpathways are Sterol Regulatory Element-Binding Proteins (SREBP) signalling and ATF-2 transcription factor network. Affiliated tissues include brain, and related phenotypes are Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) and behavior/neurological

Related Diseases for Diabetic Encephalopathy

Diseases related to Diabetic Encephalopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 alzheimer disease 27.7 CAT CREB1 DLG4 GDNF
2 encephalopathy 10.4
3 diabetic angiopathy 10.1 CAT INS
4 neuronitis 9.9
5 diabetic neuropathy 9.7 GDNF INS
6 cerebritis 9.7
7 type i 9.7
8 depression 9.7
9 cerebral atrophy 9.7
10 diabetes mellitus 9.6
11 hyperglycemia 9.6
12 asthma 9.0 CAT CREB1 INS MYLK

Graphical network of the top 20 diseases related to Diabetic Encephalopathy:



Diseases related to Diabetic Encephalopathy

Symptoms & Phenotypes for Diabetic Encephalopathy

GenomeRNAi Phenotypes related to Diabetic Encephalopathy according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 8.8 CAT INS MYLK

MGI Mouse Phenotypes related to Diabetic Encephalopathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.7 INS MAD2L2 MYLK SHANK1 CREB1 DLG4
2 homeostasis/metabolism MP:0005376 9.5 GLO1 INS MAD2L2 MYLK CAT CREB1
3 mortality/aging MP:0010768 9.17 GDNF INS MAD2L2 MYLK CAT CREB1

Drugs & Therapeutics for Diabetic Encephalopathy

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Early Warning System for the Diabetic Encephalopathy Recruiting NCT02420470

Search NIH Clinical Center for Diabetic Encephalopathy

Genetic Tests for Diabetic Encephalopathy

Anatomical Context for Diabetic Encephalopathy

MalaCards organs/tissues related to Diabetic Encephalopathy:

41
Brain

Publications for Diabetic Encephalopathy

Articles related to Diabetic Encephalopathy:

(show all 42)
# Title Authors Year
1
Identification of Protein Kinase C Isoforms Involved in Type 1 Diabetic Encephalopathy in Mice. ( 29744369 )
2018
2
Control of macrophage autophagy by miR-384-5p in the development of diabetic encephalopathy. ( 29511445 )
2018
3
Inhibiting the NLRP3 Inflammasome Activation with MCC950 Ameliorates Diabetic Encephalopathy in db/db Mice. ( 29495433 )
2018
4
Notoginsenoside R1 ameliorates diabetic encephalopathy by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation. ( 29507694 )
2018
5
Mathematical model of diabetic encephalopathy. ( 29203738 )
2017
6
Autophagy plays beneficial effect on diabetic encephalopathy in type 2 diabetes: studies in vivo and in vitro. ( 28456145 )
2017
7
Quantitative profiling of neurotransmitter abnormalities in brain, cerebrospinal fluid, and serum of experimental diabetic encephalopathy male rat. ( 28609588 )
2017
8
Coenzyme Q10 and niacin mitigate streptozotocin- induced diabetic encephalopathy in a rat model. ( 28560538 )
2017
9
Role of microglia-neuron interactions in diabetic encephalopathy. ( 29247713 )
2017
10
Berberine Improves Diabetic Encephalopathy Through the SIRT1/ER Stress Pathway in db/db Mice. ( 28782427 )
2017
11
Physiological targets for the treatment of diabetic encephalopathy. ( 27121380 )
2016
12
Protective effects of Huanglian Wendan Decoction aganist cognitive deficits and neuronal damages in rats with diabetic encephalopathy by inhibiting the release of inflammatory cytokines and repairing insulin signaling pathway in hippocampus. ( 27914525 )
2016
13
A Therapeutic Insight of Niacin and Coenzyme Q10 Against Diabetic Encephalopathy in Rats. ( 26867655 )
2016
14
Endoplasmic reticulum stress-induced neuronal inflammatory response and apoptosis likely plays a key role in the development of diabetic encephalopathy. ( 27793043 )
2016
15
A novel role for the calcium sensing receptor in rat diabetic encephalopathy. ( 25547907 )
2015
16
GABAergic Modulation in Diabetic Encephalopathy-Related Depression. ( 26365139 )
2015
17
Quantitative-profiling of neurotransmitter abnormalities in the disease progression of experimental diabetic encephalopathy rat. ( 26426748 )
2015
18
The Protective Effect of Radix Polygoni Multiflori on Diabetic Encephalopathy via Regulating Myosin Light Chain Kinase Expression. ( 26199947 )
2015
19
Upregulation of pa89Akt by glial cell linea89derived neurotrophic factor ameliorates cell apoptosis in the hippocampus of rats with streptozotocina89induced diabetic encephalopathy. ( 26549420 )
2015
20
Role of the Insulin-Like Growth Factor Type 1 Receptor in the Pathogenesis of Diabetic Encephalopathy. ( 26089889 )
2015
21
Inflammatory Macrophages Promotes Development of Diabetic Encephalopathy. ( 26113412 )
2015
22
Diabetic encephalopathy-related depression: experimental evidence that insulin and clonazepam restore antioxidant status in rat brain. ( 25431174 )
2014
23
Cerebroprotective effects of ibuprofen on diabetic encephalopathy in rats. ( 24291733 )
2014
24
Ameliorative effect of saffron aqueous extract on hyperglycemia, hyperlipidemia, and oxidative stress on diabetic encephalopathy in streptozotocin induced experimental diabetes mellitus. ( 25114929 )
2014
25
Retraction. Francis GJ, Martinez JA, Liu WQ, Xu K, Ayer A, Fine J, Tuor UI, Glazner G, Hanson LR, Frey WH 2nd, Toth C. Intranasal insulin prevents cognitive decline, cerebral atrophy and white matter changes in murine type I diabetic encephalopathy. Brain 2008 Dec;131(Pt 12):3311a8934. doi:10.1093/brain/awn288. ( 24860127 )
2014
26
L-type calcium channel blocker ameliorates diabetic encephalopathy by modulating dysregulated calcium homeostasis. ( 25267297 )
2014
27
Axonal and dendritic changes are associated with diabetic encephalopathy in rats: an important risk factor for Alzheimer's disease. ( 23302655 )
2013
28
Hypoglycemic and antioxidant activities of paeonol and its beneficial effect on diabetic encephalopathy in streptozotocin-induced diabetic rats. ( 23875897 )
2013
29
Neuroprotective effect of paeonol on cognition deficits of diabetic encephalopathy in streptozotocin-induced diabetic rat. ( 23791853 )
2013
30
Luteolin attenuates neuronal apoptosis in the hippocampi of diabetic encephalopathy rats. ( 25206401 )
2013
31
Neuroprotective effect of Liuwei Dihuang decoction on cognition deficits of diabetic encephalopathy in streptozotocin-induced diabetic rat. ( 24041458 )
2013
32
Effects of amyloid precursor protein 17 peptide on the protection of diabetic encephalopathy and improvement of glycol metabolism in the diabetic rat. ( 23844373 )
2013
33
Neuroprotective properties of aucubin in diabetic rats and diabetic encephalopathy rats. ( 22810648 )
2012
34
C-peptide and diabetic encephalopathy. ( 21703121 )
2011
35
Choline-deprivation alters crucial brain enzyme activities in a rat model of diabetic encephalopathy. ( 20838865 )
2010
36
Oral supplementation of catalpol ameliorates diabetic encephalopathy in rats. ( 19852947 )
2010
37
Aucubin prevents loss of hippocampal neurons and regulates antioxidative activity in diabetic encephalopathy rats. ( 19140154 )
2009
38
Inflammation in Diabetic Encephalopathy is Prevented by C-Peptide. ( 19557294 )
2009
39
Sequential abnormalities in type 1 diabetic encephalopathy and the effects of C-Peptide. ( 20039010 )
2009
40
Neuroprotection in diabetic encephalopathy. ( 20145418 )
2009
41
Intranasal insulin prevents cognitive decline, cerebral atrophy and white matter changes in murine type I diabetic encephalopathy. ( 19015157 )
2008
42
Neuroprotective effect of N-acetylcysteine in the development of diabetic encephalopathy in streptozotocin-induced diabetes. ( 18802743 )
2008

Variations for Diabetic Encephalopathy

Expression for Diabetic Encephalopathy

Search GEO for disease gene expression data for Diabetic Encephalopathy.

Pathways for Diabetic Encephalopathy

Pathways related to Diabetic Encephalopathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.23 CREB1 INS
2 11.06 CREB1 INS
3
Show member pathways
10.98 CAT CREB1 INS
4 10.9 CREB1 INS
5 10.74 CREB1 GDNF
6 10.49 CREB1 DLG4

GO Terms for Diabetic Encephalopathy

Cellular components related to Diabetic Encephalopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 excitatory synapse GO:0060076 9.16 DLG4 SHANK1
2 ionotropic glutamate receptor complex GO:0008328 8.96 DLG4 SHANK1
3 neuron spine GO:0044309 8.62 DLG4 SHANK1

Biological processes related to Diabetic Encephalopathy according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.71 CAT GDNF GLO1 INS
2 MAPK cascade GO:0000165 9.67 DLG4 GDNF INS
3 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.57 CAT INS
4 cellular response to growth factor stimulus GO:0071363 9.56 CAT CREB1
5 social behavior GO:0035176 9.55 DLG4 SHANK1
6 positive regulation of cell differentiation GO:0045597 9.54 GDNF INS
7 neuromuscular process controlling balance GO:0050885 9.52 DLG4 SHANK1
8 ureteric bud development GO:0001657 9.51 CAT GDNF
9 response to activity GO:0014823 9.48 CAT CREB1
10 negative regulation of protein catabolic process GO:0042177 9.46 INS MAD2L2
11 positive regulation of excitatory postsynaptic potential GO:2000463 9.43 DLG4 SHANK1
12 positive regulation of long-term synaptic potentiation GO:1900273 9.37 CREB1 INS
13 dendritic spine morphogenesis GO:0060997 9.32 DLG4 SHANK1
14 positive regulation of lipid biosynthetic process GO:0046889 9.26 CREB1 INS
15 vocalization behavior GO:0071625 9.16 DLG4 SHANK1
16 protein localization to synapse GO:0035418 8.96 DLG4 SHANK1
17 negative regulation of transcription by competitive promoter binding GO:0010944 8.62 CREB1 MAD2L2

Molecular functions related to Diabetic Encephalopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 scaffold protein binding GO:0097110 9.16 DLG4 SHANK1
2 RNA polymerase II activating transcription factor binding GO:0001102 8.96 CREB1 MAD2L2
3 ionotropic glutamate receptor binding GO:0035255 8.62 DLG4 SHANK1

Sources for Diabetic Encephalopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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