MCID: DBT081
MIFTS: 36

Diabetic Encephalopathy

Categories: Neuronal diseases

Aliases & Classifications for Diabetic Encephalopathy

MalaCards integrated aliases for Diabetic Encephalopathy:

Name: Diabetic Encephalopathy 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050850

Summaries for Diabetic Encephalopathy

Disease Ontology : 12 A brain disease that is characterized by functional impairment of cognition, cerebral signal conduction, neurotransmission and synaptic plasticity, and underlying structural pathology associated with diabetes.

MalaCards based summary : Diabetic Encephalopathy is related to hyperglycemia and diabetic neuropathy. An important gene associated with Diabetic Encephalopathy is CREB1 (CAMP Responsive Element Binding Protein 1), and among its related pathways/superpathways are Apoptotic Pathways in Synovial Fibroblasts and ERK Signaling. Affiliated tissues include brain, cortex and endothelial, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Diabetic Encephalopathy

Diseases related to Diabetic Encephalopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 186)
# Related Disease Score Top Affiliating Genes
1 hyperglycemia 30.2 IRS1 INS IGF1 AKT1
2 diabetic neuropathy 30.1 NGF INS GDNF
3 microvascular complications of diabetes 5 29.9 INS IGF1 AKT1
4 microvascular complications of diabetes 1 29.6 INS IL1B IGF1
5 central nervous system disease 29.4 NGF IL1B HMOX1 BDNF
6 liver disease 29.4 IRS1 INS IL1B CASP3 AKT1
7 hyperinsulinism 29.3 SLC2A4 IRS1 INS IGF1
8 nervous system disease 28.3 NGF INS IL1B IGF1 GDNF CASP3
9 peripheral nervous system disease 28.0 NGF INS IL1B IGF1 HMOX1 GDNF
10 diabetes mellitus 27.5 SLC2A4 NFE2L2 IRS1 INS IL1B IGF1
11 type 2 diabetes mellitus 27.3 SLC2A4 NFE2L2 IRS1 INS IL1B IGF1
12 encephalopathy 10.7
13 algoneurodystrophy 10.3 NGF INS
14 neurogenic arthropathy 10.3 NGF INS
15 adrenal gland pheochromocytoma 10.3 NGF BDNF
16 myofascial pain syndrome 10.3 NGF BDNF
17 hypoganglionosis 10.3 GDNF ACHE
18 ocular dominance 10.2 NGF CREB1 BDNF
19 cerebral artery occlusion 10.2 IL1B GDNF BDNF
20 secondary adrenal insufficiency 10.2 INS IGF1
21 hypothalamic obesity 10.2 INS IGF1
22 endogenous depression 10.2 INS IL1B BDNF
23 asphyxia neonatorum 10.2 INS CASP3 BDNF
24 pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities 10.2 INS IGF1
25 fetal alcohol spectrum disorder 10.2 CREB1 CASP3 BDNF
26 spinal cord injury 10.2 GDNF CASP3 BDNF
27 meningoencephalitis 10.2 NGF GDNF BDNF
28 acidophil adenoma 10.2 INS IGF1
29 kaufman oculocerebrofacial syndrome 10.2 INS IL1B BDNF
30 chronic ulcer of skin 10.2 NGF INS IL1B
31 dry eye syndrome 10.2 NGF GDNF BDNF
32 secondary progressive multiple sclerosis 10.2 NGF GDNF BDNF
33 actinomycosis 10.2 INS IL1B CASP3
34 pituitary infarct 10.2 INS IGF1
35 occlusion precerebral artery 10.2 IL1B CASP3 BDNF
36 human cytomegalovirus infection 10.2 IL1B CREB1 CASP3
37 hair disease 10.2 INS IL1B AKT1
38 encephalomalacia 10.2 IL1B CASP3 BDNF
39 carotid artery occlusion 10.2 IL1B CASP3 BDNF
40 somatoform disorder 10.1 NGF IL1B BDNF
41 pain agnosia 10.1 NGF IL1B BDNF
42 paine syndrome 10.1 NGF IL1B BDNF
43 potter's syndrome 10.1 INS IGF1
44 cystitis 10.1 NGF GDNF BDNF
45 lipid storage disease 10.1 INS IL1B AKT1
46 irritable bowel syndrome 10.1 NGF IL1B BDNF
47 metachromatic leukodystrophy 10.1 INS GDNF CASP3
48 thiamine deficiency disease 10.1 NGF BDNF ACHE
49 marasmus 10.1 INS IGF1
50 wernicke-korsakoff syndrome 10.1 NGF BDNF ACHE

Graphical network of the top 20 diseases related to Diabetic Encephalopathy:



Diseases related to Diabetic Encephalopathy

Symptoms & Phenotypes for Diabetic Encephalopathy

GenomeRNAi Phenotypes related to Diabetic Encephalopathy according to GeneCards Suite gene sharing:

26 (show all 22)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-1 9.98 GRB10
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-102 9.98 IGF1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.98 IGF1 NGF
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-107 9.98 ACHE
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.98 IGF1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-144 9.98 IGF1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.98 IGF1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-161 9.98 NGF
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-167 9.98 GRB10
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.98 IGF1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-209 9.98 GRB10
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-21 9.98 IGF1
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.98 IGF1
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.98 IGF1
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-37 9.98 GRB10
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-39 9.98 GRB10
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-46 9.98 GRB10
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-6 9.98 NGF
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.98 ACHE
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.98 IGF1
21 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.28 AKT1 CASP3 IL1B
22 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.28 AKT1 CASP3 GDNF HMOX1 IL1B NFE2L2

MGI Mouse Phenotypes related to Diabetic Encephalopathy:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.37 ACHE AKT1 BDNF CASP3 CREB1 GDNF
2 cardiovascular system MP:0005385 10.35 ACHE AKT1 CASP3 CREB1 GDNF HMOX1
3 cellular MP:0005384 10.3 AKT1 BDNF CASP3 CREB1 GDNF GRB10
4 homeostasis/metabolism MP:0005376 10.3 ACHE AKT1 BDNF CASP3 CREB1 GRB10
5 endocrine/exocrine gland MP:0005379 10.25 AKT1 BDNF CASP3 CREB1 GDNF GRB10
6 adipose tissue MP:0005375 10.2 ACHE AKT1 GRB10 HMOX1 IGF1 INS
7 mortality/aging MP:0010768 10.2 ACHE AKT1 BDNF CASP3 CREB1 GDNF
8 hematopoietic system MP:0005397 10.18 ACHE AKT1 CASP3 GDNF HMOX1 IGF1
9 immune system MP:0005387 10.13 AKT1 CASP3 GDNF HMOX1 IGF1 IL1B
10 muscle MP:0005369 10.03 ACHE AKT1 CASP3 CREB1 GDNF GRB10
11 integument MP:0010771 10.01 AKT1 BDNF CASP3 IGF1 IL1B INS
12 nervous system MP:0003631 9.93 ACHE AKT1 BDNF CASP3 CREB1 GDNF
13 liver/biliary system MP:0005370 9.91 AKT1 GRB10 HMOX1 INS IRS1 NFE2L2
14 reproductive system MP:0005389 9.61 ACHE AKT1 BDNF CASP3 CREB1 GDNF
15 respiratory system MP:0005388 9.28 ACHE AKT1 BDNF CASP3 CREB1 GRB10

Drugs & Therapeutics for Diabetic Encephalopathy

Search Clinical Trials , NIH Clinical Center for Diabetic Encephalopathy

Genetic Tests for Diabetic Encephalopathy

Anatomical Context for Diabetic Encephalopathy

MalaCards organs/tissues related to Diabetic Encephalopathy:

40
Brain, Cortex, Endothelial, Retina, Kidney, Pancreas

Publications for Diabetic Encephalopathy

Articles related to Diabetic Encephalopathy:

(show top 50) (show all 249)
# Title Authors PMID Year
1
Kuwanon G protects HT22 cells from advanced glycation end product-induced damage. 61
33747164 2021
2
A RNA-seq approach for exploring the protective effect of ginkgolide B on glutamate-induced astrocytes injury. 61
33450290 2021
3
Effect of diet supplemented with P. ostreatus and L. subnudus on memory index and key enzymes linked with Alzheimer's disease in streptozotocin-induced diabetes rats. 61
32628296 2021
4
Hydrogen sulfide ameliorates high glucose-induced pro-inflammation factors in HT-22 cells: Involvement of SIRT1-mTOR/NF-κB signaling pathway. 61
33765609 2021
5
Curcumin and its analog alleviate diabetes-induced damages by regulating inflammation and oxidative stress in brain of diabetic rats. 61
33602334 2021
6
The Association between Hepatic Encephalopathy and Diabetic Encephalopathy: The Brain-Liver Axis. 61
33466498 2021
7
Berberine elevates mitochondrial membrane potential and decreases reactive oxygen species by inhibiting the Rho/ROCK pathway in rats with diabetic encephalopathy. 61
33632015 2021
8
Explore of the beneficial effects of Huang-Lian-Jie-Du Decoction on diabetic encephalopathy in db/db mice by UPLC-Q-Orbitrap HRMS/MS based untargeted metabolomics analysis. 61
33039912 2021
9
[Effects of Moringa flavone on cognitive function and neuropathological indexes in diabetic encephalopathy rats]. 61
33541503 2020
10
Decreased miR-132 plays a crucial role in diabetic encephalopathy by regulating the GSK-3β/Tau pathway. 61
33406505 2020
11
Altered regional homogeneity and functional brain networks in Type 2 diabetes with and without mild cognitive impairment. 61
33277510 2020
12
Design, microwave synthesis, and molecular docking studies of catalpol crotonates as potential neuroprotective agent of diabetic encephalopathy. 61
33230173 2020
13
Construction and preliminary characterization of human recombinant proNGF-A variant. 61
32758589 2020
14
NGF receptors and PI3K/AKT pathway involved in glucose fluctuation-induced damage to neurons and α-lipoic acid treatment. 61
32943002 2020
15
Diabetic encephalopathy causes the imbalance of neural activities between hippocampal glutamatergic neurons and GABAergic neurons in mice. 61
32360099 2020
16
A novel hippocampus metabolite signature in diabetes mellitus rat model of diabetic encephalopathy. 61
32367268 2020
17
Sulforaphane attenuates apoptosis of hippocampal neurons induced by high glucose via regulating endoplasmic reticulum. 61
32199985 2020
18
The neuroprotective effect and action mechanism of polyphenols in diabetes mellitus-related cognitive dysfunction. 61
31598747 2020
19
Evaluating blood-brain barrier permeability in a rat model of type 2 diabetes. 61
32580725 2020
20
Deferoxamine regulates neuroinflammation and oxidative stress in rats with diabetes-induced cognitive dysfunction. 61
31786804 2020
21
Quercetin ameliorates diabetic encephalopathy through SIRT1/ER stress pathway in db/db mice. 61
32312941 2020
22
Quercetin protects against diabetic encephalopathy via SIRT1/NLRP3 pathway in db/db mice. 61
32000299 2020
23
Studies of pathology and pharmacology of diabetic encephalopathy with KK-Ay mouse model. 61
31401815 2020
24
Increased Brain Iron Deposition in the Putamen in Patients with Type 2 Diabetes Mellitus Detected by Quantitative Susceptibility Mapping. 61
33062715 2020
25
Corrigendum to "Ameliorative Effect of Saffron Aqueous Extract on Hyperglycemia, Hyperlipidemia, and Oxidative Stress on Diabetic Encephalopathy in Streptozotocin Induced Experimental Diabetes Mellitus". 61
33376739 2020
26
Lipin1 Is Involved in the Pathogenesis of Diabetic Encephalopathy through the PKD/Limk/Cofilin Signaling Pathway. 61
33123308 2020
27
Neuroprotection of dihydrotestosterone via suppression of the toll-like receptor 4/nuclear factor-kappa B signaling pathway in high glucose-induced BV-2 microglia inflammatory responses. 61
31876682 2020
28
Fisetin Prevents HT22 Cells From High Glucose-Induced Neurotoxicity via PI3K/Akt/CREB Signaling Pathway. 61
32265642 2020
29
Type 1 diabetes induces cognitive dysfunction in rats associated with alterations of the gut microbiome and metabolomes in serum and hippocampus. 61
31472216 2019
30
Ginsenoside Rb1 mitigates oxidative stress and apoptosis induced by methylglyoxal in SH-SY5Y cells via the PI3K/Akt pathway. 61
31629029 2019
31
Chronic oleoylethanolamide treatment attenuates diabetes-induced mice encephalopathy by triggering peroxisome proliferator-activated receptor alpha in the hippocampus. 61
31299417 2019
32
Sodium ferulate attenuates high-glucose-induced oxidative injury in HT22 hippocampal cells. 61
31452700 2019
33
Neuroprotective effects of an Nrf2 agonist on high glucose-induced damage in HT22 cells. 61
31542051 2019
34
Application of neurite orientation dispersion and density imaging to characterize brain microstructural abnormalities in type-2 diabetics with mild cognitive impairment. 61
30779402 2019
35
D-ribose is elevated in T1DM patients and can be involved in the onset of encephalopathy. 61
31307014 2019
36
Brain microstructural alterations in type 2 diabetes: diffusion kurtosis imaging provides added value to diffusion tensor imaging. 61
30338363 2019
37
Chronic insulinopenia/hyperglycemia decreases cannabinoid CB1 receptor density and impairs glucose uptake in the mouse forebrain. 61
30721768 2019
38
Antidiabetic treatment on memory and spatial learning: From the pancreas to the neuron. 61
30891152 2019
39
Notoginsenoside R1 Ameliorates Diabetic Retinopathy through PINK1-Dependent Activation of Mitophagy. 61
30832367 2019
40
Protective effects of Liuwei dihuang water extracts on diabetic muscle atrophy. 61
30668418 2019
41
Diabetic encephalopathy: beneficial effects of supplementation with fatty acids ω3 and nordihydroguaiaretic acid in a spontaneous diabetes rat model. 61
30736810 2019
42
Effects of Tianqijiangtang capsule on survival, self-renewal and differentiation of hippocampal neural stem cells of embryonic rats cultured in high glucose medium. 61
31632529 2019
43
Corrigendum: Role of Hippocampal Lipocalin-2 in Experimental Diabetic Encephalopathy. 61
31024460 2019
44
Effect of the APP17 peptide on diabetic encephalopathy. 61
30693738 2019
45
Role of Hippocampal Lipocalin-2 in Experimental Diabetic Encephalopathy. 61
30761088 2019
46
D-Ribose Induces Podocyte NLRP3 Inflammasome Activation and Glomerular Injury via AGEs/RAGE Pathway. 61
31737627 2019
47
Rhizoma coptidis as a Potential Treatment Agent for Type 2 Diabetes Mellitus and the Underlying Mechanisms: A Review. 61
31396083 2019
48
TGF-beta/TGF-beta RII/CLC-3 axis promotes cognitive disorders in diabetes. 61
30468668 2019
49
Metformin attenuates diabetes-induced tau hyperphosphorylation in vitro and in vivo by enhancing autophagic clearance. 61
30219731 2019
50
Icariin Inhibits AGE-Induced Injury in PC12 Cells by Directly Targeting Apoptosis Regulator Bax. 61
31178973 2019

Variations for Diabetic Encephalopathy

Expression for Diabetic Encephalopathy

Search GEO for disease gene expression data for Diabetic Encephalopathy.

Pathways for Diabetic Encephalopathy

Pathways related to Diabetic Encephalopathy according to GeneCards Suite gene sharing:

(show top 50) (show all 91)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.84 NGF INS IL1B IGF1 CREB1 CASP3
2
Show member pathways
13.82 NGF IRS1 IL1B IGF1 CREB1 CASP3
3
Show member pathways
13.66 SLC2A4 NGF INS IL1B GDNF CREB1
4
Show member pathways
13.54 NGF IRS1 INS IL1B IGF1 CREB1
5
Show member pathways
13.5 SLC2A4 IRS1 INS GRB10 GDNF CREB1
6
Show member pathways
13.46 IRS1 INS IL1B CREB1 CASP3 BDNF
7
Show member pathways
13.4 SLC2A4 IRS1 INS IL1B CREB1 CASP3
8
Show member pathways
13.35 IRS1 IL1B HMOX1 GDNF CASP3 AKT1
9
Show member pathways
13.31 SLC2A4 NGF IL1B IGF1 CASP3 BDNF
10
Show member pathways
13.31 SLC2A4 NGF IRS1 IL1B IGF1 CREB1
11
Show member pathways
13.22 SLC2A4 IRS1 IL1B IGF1 CREB1 AKT1
12
Show member pathways
13.06 NGF IRS1 INS IGF1 BDNF AKT1
13
Show member pathways
12.9 SLC2A4 IRS1 INS IGF1 GRB10 AKT1
14
Show member pathways
12.88 SLC2A4 IRS1 IGF1 CREB1 AKT1
15
Show member pathways
12.87 INS IL1B GDNF CREB1 CASP3
16 12.86 NFE2L2 IGF1 HMOX1 CASP3 AKT1
17
Show member pathways
12.85 IRS1 INS IGF1 CREB1 CASP3 AKT1
18
Show member pathways
12.8 SLC2A4 IRS1 INS CREB1 AKT1
19
Show member pathways
12.76 NGF INS IGF1 BDNF AKT1
20
Show member pathways
12.73 NGF IL1B IGF1 BDNF AKT1
21
Show member pathways
12.71 NGF IRS1 CREB1 CASP3 BDNF AKT1
22
Show member pathways
12.66 IL1B CREB1 CASP3 AKT1
23
Show member pathways
12.64 NGF IL1B IGF1 AKT1
24
Show member pathways
12.59 NGF IL1B CASP3 AKT1
25
Show member pathways
12.56 IRS1 INS CREB1 AKT1
26
Show member pathways
12.56 SLC2A4 NGF IRS1 INS GRB10 BDNF
27 12.54 SLC2A4 IRS1 INS AKT1
28
Show member pathways
12.53 SLC2A4 IRS1 INS GRB10 AKT1
29
Show member pathways
12.5 IRS1 INS IGF1 GRB10 AKT1
30
Show member pathways
12.42 IRS1 IGF1 CREB1 AKT1
31
Show member pathways
12.39 NGF IRS1 INS IGF1 CREB1 CASP3
32
Show member pathways
12.37 SLC2A4 IRS1 INS IGF1 CREB1 AKT1
33 12.37 NGF INS IL1B IGF1 CASP3 BDNF
34
Show member pathways
12.35 IRS1 IGF1 CREB1 AKT1
35
Show member pathways
12.33 IRS1 CREB1 CASP3 AKT1
36
Show member pathways
12.33 IRS1 INS IL1B CREB1 CASP3 AKT1
37
Show member pathways
12.29 NGF IL1B IGF1 BDNF AKT1
38 12.27 IL1B CREB1 CASP3 AKT1
39
Show member pathways
12.24 IRS1 CREB1 CASP3 AKT1
40
Show member pathways
12.24 SLC2A4 IRS1 INS AKT1
41
Show member pathways
12.24 IRS1 IGF1 CASP3 AKT1
42 12.18 IRS1 CREB1 CASP3 AKT1
43
Show member pathways
12.18 NGF CREB1 CASP3 AKT1
44
Show member pathways
12.18 IRS1 GDNF CREB1 BDNF AKT1
45 12.16 NGF IL1B CREB1 CASP3 BDNF
46 12.13 NFE2L2 IL1B HMOX1 AKT1
47
Show member pathways
12.1 IRS1 INS IGF1 CREB1 AKT1
48 12.05 IL1B CREB1 AKT1
49 12.04 IL1B GDNF CASP3 BDNF
50
Show member pathways
12.03 SLC2A4 IRS1 INS IGF1 AKT1

GO Terms for Diabetic Encephalopathy

Cellular components related to Diabetic Encephalopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.23 NGF INS IL1B IGF1 HMOX1 GDNF
2 endosome lumen GO:0031904 8.96 NGF INS

Biological processes related to Diabetic Encephalopathy according to GeneCards Suite gene sharing:

(show all 43)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.13 IRS1 INS IL1B IGF1 GRB10 GDNF
2 positive regulation of transcription, DNA-templated GO:0045893 10.08 NFE2L2 IL1B IGF1 CREB1 AKT1
3 negative regulation of apoptotic process GO:0043066 10.04 NGF IGF1 GDNF CASP3 AKT1
4 positive regulation of apoptotic process GO:0043065 10.01 NGF HMOX1 CREB1 CASP3 AKT1
5 response to drug GO:0042493 9.96 NFE2L2 HMOX1 CREB1 CASP3
6 cytokine-mediated signaling pathway GO:0019221 9.96 IL1B HMOX1 CASP3 AKT1
7 positive regulation of cell proliferation GO:0008284 9.93 IRS1 INS IL1B IGF1 GDNF AKT1
8 positive regulation of gene expression GO:0010628 9.91 NGF NFE2L2 INS IL1B IGF1 AKT1
9 negative regulation of neuron apoptotic process GO:0043524 9.88 NGF HMOX1 GDNF BDNF
10 wound healing GO:0042060 9.85 INS IGF1 CASP3
11 cellular response to insulin stimulus GO:0032869 9.85 SLC2A4 IRS1 AKT1
12 cellular response to hypoxia GO:0071456 9.85 SLC2A4 NFE2L2 HMOX1 AKT1
13 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.83 NGF BDNF AKT1
14 response to organic substance GO:0010033 9.83 CREB1 CASP3 AKT1
15 memory GO:0007613 9.82 NGF CREB1 BDNF
16 cellular response to organic cyclic compound GO:0071407 9.8 IL1B CASP3 AKT1
17 positive regulation of smooth muscle cell proliferation GO:0048661 9.8 IGF1 HMOX1 AKT1
18 glucose homeostasis GO:0042593 9.8 SLC2A4 IRS1 INS AKT1
19 phosphatidylinositol-mediated signaling GO:0048015 9.79 NGF IRS1 IGF1
20 protein kinase B signaling GO:0043491 9.78 IL1B IGF1 AKT1
21 negative regulation of insulin receptor signaling pathway GO:0046627 9.77 IRS1 IL1B GRB10
22 phosphatidylinositol 3-kinase signaling GO:0014065 9.77 IRS1 IGF1 AKT1
23 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.75 IL1B GDNF AKT1
24 activation of protein kinase B activity GO:0032148 9.74 INS IGF1 AKT1
25 response to nicotine GO:0035094 9.73 HMOX1 CREB1 CASP3
26 positive regulation of mitotic nuclear division GO:0045840 9.7 INS IL1B IGF1
27 negative regulation of lipid catabolic process GO:0050995 9.69 INS IL1B
28 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.69 IL1B GRB10
29 peripheral nervous system development GO:0007422 9.69 NGF GDNF BDNF
30 positive regulation of cellular protein metabolic process GO:0032270 9.68 INS AKT1
31 nerve development GO:0021675 9.68 NGF BDNF
32 negative regulation of macroautophagy GO:0016242 9.68 HMOX1 AKT1
33 nerve growth factor signaling pathway GO:0038180 9.67 NGF BDNF
34 insulin receptor signaling pathway GO:0008286 9.67 IRS1 INS GRB10 AKT1
35 positive regulation of glucose metabolic process GO:0010907 9.65 IRS1 AKT1
36 positive regulation of collateral sprouting GO:0048672 9.63 NGF BDNF
37 neurotrophin TRK receptor signaling pathway GO:0048011 9.58 NGF CASP3 BDNF
38 positive regulation of brain-derived neurotrophic factor receptor signaling pathway GO:0031550 9.54 SLC2A4 BDNF
39 positive regulation of lipid biosynthetic process GO:0046889 9.5 INS CREB1 AKT1
40 positive regulation of glycogen biosynthetic process GO:0045725 9.46 IRS1 INS IGF1 AKT1
41 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176 9.43 NFE2L2 INS AKT1
42 insulin-like growth factor receptor signaling pathway GO:0048009 9.26 IRS1 IGF1 GRB10 AKT1
43 positive regulation of glucose import GO:0046326 9.02 NFE2L2 IRS1 INS IGF1 AKT1

Molecular functions related to Diabetic Encephalopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.46 NGF IGF1 GDNF BDNF
2 nerve growth factor receptor binding GO:0005163 9.26 NGF BDNF
3 insulin-like growth factor receptor binding GO:0005159 9.13 IRS1 INS IGF1
4 insulin receptor binding GO:0005158 8.92 IRS1 INS IGF1 GRB10

Sources for Diabetic Encephalopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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