MCID: DBT081
MIFTS: 28

Diabetic Encephalopathy

Categories: Neuronal diseases

Aliases & Classifications for Diabetic Encephalopathy

MalaCards integrated aliases for Diabetic Encephalopathy:

Name: Diabetic Encephalopathy 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050850

Summaries for Diabetic Encephalopathy

Disease Ontology : 12 A brain disease that is characterized by functional impairment of cognition, cerebral signal conduction, neurotransmission and synaptic plasticity, and underlying structural pathology associated with diabetes.

MalaCards based summary : Diabetic Encephalopathy is related to encephalopathy and pigmentation disease. An important gene associated with Diabetic Encephalopathy is CREB1 (CAMP Responsive Element Binding Protein 1), and among its related pathways/superpathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Sterol Regulatory Element-Binding Proteins (SREBP) signalling. Affiliated tissues include brain, kidney and cortex, and related phenotypes are behavior/neurological and homeostasis/metabolism

Related Diseases for Diabetic Encephalopathy

Diseases related to Diabetic Encephalopathy via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 encephalopathy 10.6
2 pigmentation disease 10.0 CREB1 INS
3 diabetic neuropathy 9.9 GDNF GLO1 INS
4 diabetic angiopathy 9.9 CAT INS
5 depression 9.8
6 cerebral atrophy 9.8
7 alzheimer disease 9.7
8 diabetes mellitus 9.7
9 hyperglycemia 9.7

Graphical network of the top 20 diseases related to Diabetic Encephalopathy:



Diseases related to Diabetic Encephalopathy

Symptoms & Phenotypes for Diabetic Encephalopathy

MGI Mouse Phenotypes related to Diabetic Encephalopathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.5 COX4I2 CREB1 DLG4 GDNF INS MAD2L2
2 homeostasis/metabolism MP:0005376 9.17 CAT COX4I2 CREB1 DLG4 GLO1 INS

Drugs & Therapeutics for Diabetic Encephalopathy

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Early Warning System for the Diabetic Encephalopathy Recruiting NCT02420470

Search NIH Clinical Center for Diabetic Encephalopathy

Genetic Tests for Diabetic Encephalopathy

Anatomical Context for Diabetic Encephalopathy

MalaCards organs/tissues related to Diabetic Encephalopathy:

41
Brain, Kidney, Cortex

Publications for Diabetic Encephalopathy

Articles related to Diabetic Encephalopathy:

(show top 50) (show all 60)
# Title Authors Year
1
Identification of Protein Kinase C Isoforms Involved in Type 1 Diabetic Encephalopathy in Mice. ( 29744369 )
2018
2
Control of macrophage autophagy by miR-384-5p in the development of diabetic encephalopathy. ( 29511445 )
2018
3
Inhibiting the NLRP3 Inflammasome Activation with MCC950 Ameliorates Diabetic Encephalopathy in db/db Mice. ( 29495433 )
2018
4
Notoginsenoside R1 ameliorates diabetic encephalopathy by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation. ( 29507694 )
2018
5
Simultaneous determination of nine analytes related to the pathogenesis of diabetic encephalopathy in diabetic rat cortex and hippocampus by HPLC-FLD. ( 30003560 )
2018
6
Morphological and Pathological Characteristics of Brain in Diabetic Encephalopathy. ( 30040723 )
2018
7
Berberine Alleviates Tau Hyperphosphorylation and Axonopathy-Associated with Diabetic Encephalopathy via Restoring PI3K/Akt/GSK3β Pathway. ( 30175975 )
2018
8
Autophagy of macrophages is regulated by PI3k/Akt/mTOR signalling in the development of diabetic encephalopathy. ( 30346929 )
2018
9
Mathematical model of diabetic encephalopathy. ( 29203738 )
2017
10
Autophagy plays beneficial effect on diabetic encephalopathy in type 2 diabetes: studies in vivo and in vitro. ( 28456145 )
2017
11
Quantitative profiling of neurotransmitter abnormalities in brain, cerebrospinal fluid, and serum of experimental diabetic encephalopathy male rat. ( 28609588 )
2017
12
Coenzyme Q10 and niacin mitigate streptozotocin- induced diabetic encephalopathy in a rat model. ( 28560538 )
2017
13
Role of microglia-neuron interactions in diabetic encephalopathy. ( 29247713 )
2017
14
Berberine Improves Diabetic Encephalopathy Through the SIRT1/ER Stress Pathway in db/db Mice. ( 28782427 )
2017
15
Erratum to: A Therapeutic Insight of Niacin and Coenzyme Q10 against Diabetic Encephalopathy in Rats. ( 28321767 )
2017
16
Physiological targets for the treatment of diabetic encephalopathy. ( 27121380 )
2016
17
Protective effects of Huanglian Wendan Decoction aganist cognitive deficits and neuronal damages in rats with diabetic encephalopathy by inhibiting the release of inflammatory cytokines and repairing insulin signaling pathway in hippocampus. ( 27914525 )
2016
18
A Therapeutic Insight of Niacin and Coenzyme Q10 Against Diabetic Encephalopathy in Rats. ( 26867655 )
2016
19
Endoplasmic reticulum stress-induced neuronal inflammatory response and apoptosis likely plays a key role in the development of diabetic encephalopathy. ( 27793043 )
2016
20
A novel role for the calcium sensing receptor in rat diabetic encephalopathy. ( 25547907 )
2015
21
GABAergic Modulation in Diabetic Encephalopathy-Related Depression. ( 26365139 )
2015
22
Quantitative-profiling of neurotransmitter abnormalities in the disease progression of experimental diabetic encephalopathy rat. ( 26426748 )
2015
23
The Protective Effect of Radix Polygoni Multiflori on Diabetic Encephalopathy via Regulating Myosin Light Chain Kinase Expression. ( 26199947 )
2015
24
Upregulation of pa89Akt by glial cell linea89derived neurotrophic factor ameliorates cell apoptosis in the hippocampus of rats with streptozotocina89induced diabetic encephalopathy. ( 26549420 )
2015
25
Role of the Insulin-Like Growth Factor Type 1 Receptor in the Pathogenesis of Diabetic Encephalopathy. ( 26089889 )
2015
26
Inflammatory Macrophages Promotes Development of Diabetic Encephalopathy. ( 26113412 )
2015
27
Diabetic encephalopathy-related depression: experimental evidence that insulin and clonazepam restore antioxidant status in rat brain. ( 25431174 )
2014
28
Cerebroprotective effects of ibuprofen on diabetic encephalopathy in rats. ( 24291733 )
2014
29
Ameliorative effect of saffron aqueous extract on hyperglycemia, hyperlipidemia, and oxidative stress on diabetic encephalopathy in streptozotocin induced experimental diabetes mellitus. ( 25114929 )
2014
30
Retraction. Francis GJ, Martinez JA, Liu WQ, Xu K, Ayer A, Fine J, Tuor UI, Glazner G, Hanson LR, Frey WH 2nd, Toth C. Intranasal insulin prevents cognitive decline, cerebral atrophy and white matter changes in murine type I diabetic encephalopathy. Brain 2008 Dec;131(Pt 12):3311a8934. doi:10.1093/brain/awn288. ( 24860127 )
2014
31
L-type calcium channel blocker ameliorates diabetic encephalopathy by modulating dysregulated calcium homeostasis. ( 25267297 )
2014
32
Axonal and dendritic changes are associated with diabetic encephalopathy in rats: an important risk factor for Alzheimer's disease. ( 23302655 )
2013
33
Hypoglycemic and antioxidant activities of paeonol and its beneficial effect on diabetic encephalopathy in streptozotocin-induced diabetic rats. ( 23875897 )
2013
34
Neuroprotective effect of paeonol on cognition deficits of diabetic encephalopathy in streptozotocin-induced diabetic rat. ( 23791853 )
2013
35
Luteolin attenuates neuronal apoptosis in the hippocampi of diabetic encephalopathy rats. ( 25206401 )
2013
36
Neuroprotective effect of Liuwei Dihuang decoction on cognition deficits of diabetic encephalopathy in streptozotocin-induced diabetic rat. ( 24041458 )
2013
37
Effects of amyloid precursor protein 17 peptide on the protection of diabetic encephalopathy and improvement of glycol metabolism in the diabetic rat. ( 23844373 )
2013
38
Neuroprotective properties of aucubin in diabetic rats and diabetic encephalopathy rats. ( 22810648 )
2012
39
C-peptide and diabetic encephalopathy. ( 21703121 )
2011
40
Choline-deprivation alters crucial brain enzyme activities in a rat model of diabetic encephalopathy. ( 20838865 )
2010
41
Oral supplementation of catalpol ameliorates diabetic encephalopathy in rats. ( 19852947 )
2010
42
Aucubin prevents loss of hippocampal neurons and regulates antioxidative activity in diabetic encephalopathy rats. ( 19140154 )
2009
43
Inflammation in Diabetic Encephalopathy is Prevented by C-Peptide. ( 19557294 )
2009
44
Sequential abnormalities in type 1 diabetic encephalopathy and the effects of C-Peptide. ( 20039010 )
2009
45
Neuroprotection in diabetic encephalopathy. ( 20145418 )
2009
46
Intranasal insulin prevents cognitive decline, cerebral atrophy and white matter changes in murine type I diabetic encephalopathy. ( 19015157 )
2008
47
Neuroprotective effect of N-acetylcysteine in the development of diabetic encephalopathy in streptozotocin-induced diabetes. ( 18802743 )
2008
48
Neuroprotection of aucubin in primary diabetic encephalopathy. ( 18488169 )
2008
49
The TCM kidney-nourishing method for protection of brain in patients with diabetic encephalopathy. ( 17710797 )
2007
50
Curcumin attenuates diabetic encephalopathy in rats: behavioral and biochemical evidences. ( 17822693 )
2007

Variations for Diabetic Encephalopathy

Expression for Diabetic Encephalopathy

Search GEO for disease gene expression data for Diabetic Encephalopathy.

Pathways for Diabetic Encephalopathy

GO Terms for Diabetic Encephalopathy

Cellular components related to Diabetic Encephalopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 excitatory synapse GO:0060076 9.16 DLG4 SHANK1
2 ionotropic glutamate receptor complex GO:0008328 8.96 DLG4 SHANK1
3 neuron spine GO:0044309 8.62 DLG4 SHANK1

Biological processes related to Diabetic Encephalopathy according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.55 CAT INS
2 cellular response to growth factor stimulus GO:0071363 9.54 CAT CREB1
3 social behavior GO:0035176 9.52 DLG4 SHANK1
4 neuromuscular process controlling balance GO:0050885 9.51 DLG4 SHANK1
5 positive regulation of cell differentiation GO:0045597 9.49 GDNF INS
6 response to activity GO:0014823 9.48 CAT CREB1
7 ureteric bud development GO:0001657 9.46 CAT GDNF
8 negative regulation of protein catabolic process GO:0042177 9.43 INS MAD2L2
9 positive regulation of excitatory postsynaptic potential GO:2000463 9.4 DLG4 SHANK1
10 dendritic spine morphogenesis GO:0060997 9.37 DLG4 SHANK1
11 positive regulation of long-term synaptic potentiation GO:1900273 9.32 CREB1 INS
12 positive regulation of lipid biosynthetic process GO:0046889 9.26 CREB1 INS
13 protein localization to synapse GO:0035418 9.16 DLG4 SHANK1
14 vocalization behavior GO:0071625 8.96 DLG4 SHANK1
15 negative regulation of transcription by competitive promoter binding GO:0010944 8.62 CREB1 MAD2L2

Molecular functions related to Diabetic Encephalopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 scaffold protein binding GO:0097110 9.16 DLG4 SHANK1
2 RNA polymerase II activating transcription factor binding GO:0001102 8.96 CREB1 MAD2L2
3 ionotropic glutamate receptor binding GO:0035255 8.62 DLG4 SHANK1

Sources for Diabetic Encephalopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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