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MCID: DRR001
MIFTS: 57

Diarrhea

Categories: Gastrointestinal diseases, Genetic diseases, Oral diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Diarrhea

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MalaCards integrated aliases for Diarrhea:

Name: Diarrhea 12 29 6 43 44 15 40
Diarrhoea 12 15
Diarrhea of Presumed Infectious Origin 12

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Gastrointestinal diseases Oral diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:13250
ICD9CM 35 009.2
MeSH 44 D003967
SNOMED-CT 68 19213003
UMLS 73 C0013369
Sources

Summaries for Diarrhea

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MedlinePlus : 43 What is diarrhea? Diarrhea is loose, watery stools (bowel movements). You have diarrhea if you have loose stools three or more times in one day. Acute diarrhea is diarrhea that lasts a short time. It is a common problem. It usually lasts about one or two days, but it may last longer. Then it goes away on its own. Diarrhea lasting more than a few days may be a sign of a more serious problem. Chronic diarrhea -- diarrhea that lasts at least four weeks -- can be a symptom of a chronic disease. Chronic diarrhea symptoms may be continual, or they may come and go. Who is at risk for diarrhea? People of all ages can get diarrhea. On average, adults In the United States have acute diarrhea once a year. Young children have it an average of twice a year. People who visit developing countries are at risk for traveler's diarrhea. It is caused by consuming contaminated food or water. What causes diarrhea? The most common causes of diarrhea include Bacteria from contaminated food or water Viruses such as the flu, norovirus, or rotavirus . Rotavirus is the most common cause of acute diarrhea in children. Parasites, which are tiny organisms found in contaminated food or water Medicines such as antibiotics, cancer drugs, and antacids that contain magnesium Food intolerances and sensitivities, which are problems digesting certain ingredients or foods. An example is lactose intolerance. Diseases that affect the stomach, small intestine, or colon, such as Crohn's disease Problems with how the colon functions, such as irritable bowel syndrome Some people also get diarrhea after stomach surgery, because sometimes the surgeries can cause food to move through your digestive system more quickly. Sometimes no cause can be found. If your diarrhea goes away within a few days, finding the cause is usually not necessary. What other symptoms might I have with diarrhea? Other possible symptoms of diarrhea include Cramps or pain in the abdomen An urgent need to use the bathroom Loss of bowel control If a virus or bacteria is the cause of your diarrhea, you may also have a fever, chills, and bloody stools. Diarrhea can cause dehydration, which means that your body does not have enough fluid to work properly. Dehydration can be serious, especially for children, older adults, and people with weakened immune systems. When should I see a doctor for diarrhea? Although it is usually not harmful, diarrhea can become dangerous or signal a more serious problem. Contact your health care provider if you have Signs of dehydration Diarrhea for more than 2 days, if you are an adult. For children, contact the provider if it lasts more than 24 hours. Severe pain in your abdomen or rectum (for adults) A fever of 102 degrees or higher Stools containing blood or pus Stools that are black and tarry If children have diarrhea, parents or caregivers should not hesitate to call a health care provider. Diarrhea can be especially dangerous in newborns and infants. How is the cause of diarrhea diagnosed? To find the cause of diarrhea, your health care provider may Do a physical exam Ask about any medicines you are taking Test your stool or blood to look for bacteria, parasites, or other signs of disease or infection Ask you to stop eating certain foods to see whether your diarrhea goes away If you have chronic diarrhea, your health care provider may perform other tests to look for signs of disease. What are the treatments for diarrhea? Diarrhea is treated by replacing lost fluids and electrolytes to prevent dehydration. Depending on the cause of the problem, you may need medicines to stop the diarrhea or treat an infection. Adults with diarrhea should drink water, fruit juices, sports drinks, sodas without caffeine, and salty broths. As your symptoms improve, you can eat soft, bland food. Children with diarrhea should be given oral rehydration solutions to replace lost fluids and electrolytes. Can diarrhea be prevented? Two types of diarrhea can be prevented - rotavirus diarrhea and traveler's diarrhea. There are vaccines for rotavirus. They are given to babies in two or three doses. You can help prevent traveler's diarrhea by being careful about what you eat and drink when you are in developing countries: Use only bottled or purified water for drinking, making ice cubes, and brushing your teeth If you do use tap water, boil it or use iodine tablets Make sure that the cooked food you eat is fully cooked and served hot Avoid unwashed or unpeeled raw fruits and vegetables NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Diarrhea, also known as diarrhoea, is related to diarrhea 1, secretory chloride, congenital and diarrhea 8, secretory sodium, congenital. An important gene associated with Diarrhea is WNT2B (Wnt Family Member 2B), and among its related pathways/superpathways is Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Ceftriaxone and Carboprost Tromethamine have been mentioned in the context of this disorder. Affiliated tissues include colon, breast and testes, and related phenotypes are digestive/alimentary and homeostasis/metabolism

Disease Ontology : 12 A gastrointestinal system disease described as the condition of having frequent loose or liquid bowel movements. Acute diarrhea is a common cause of death in developing countries and the second most common cause of infant deaths worldwide. The loss of fluids through diarrhea can cause severe dehydration which is one cause of death in diarrhea sufferers. Along with water, sufferers also lose dangerous amounts of important salts, electrolytes, and other nutrients. There are at least four types of diarrhea

Wikipedia : 76 Diarrhea, also spelled diarrhoea, is the condition of having at least three loose or liquid bowel... more...

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Related Diseases for Diarrhea

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Diseases in the Diarrhea family:

Diarrhea 6 Diarrhea 7
Diarrhea 9 Chronic Diarrhea Due to Guanylate Cyclase 2c Overactivity
Inflammatory Diarrhea Acute Diarrhea
Congenital Diarrhea

Diseases related to Diarrhea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 710)
# Related Disease Score Top Affiliating Genes
1 diarrhea 1, secretory chloride, congenital 34.2 SLC26A3 SLC9A3
2 diarrhea 8, secretory sodium, congenital 34.1 SLC9A3 SPINT2
3 diarrhea 2, with microvillus atrophy 34.0 MYO5B SKIV2L SLC26A3 SLC9A3 TTC37
4 diarrhea 5, with tufting enteropathy, congenital 34.0 EPCAM MYO5B NEUROG3 SPINT2
5 trichohepatoenteric syndrome 1 33.7 SKIV2L TTC37
6 secretory diarrhea 33.6 FOXP3 GUCY2C MYO5B SLC26A3 SLC9A3 SPINT2
7 congenital diarrhea 33.5 DGAT1 EPCAM MYO5B NEUROG3 SKIV2L SLC9A3
8 cryptosporidiosis 32.2 CD40LG SST
9 pancreatic cholera 32.0 CCK SST
10 pancreatitis 31.8 CCK SST TMPRSS15
11 steatorrhea 30.4 CCK SST TMPRSS15
12 paralytic ileus 29.8 CCK SLC26A3
13 duodenal gastrinoma 29.8 CCK SST
14 duodenal disease 29.6 CCK SST
15 acute pancreatitis 29.6 CCK SST TMPRSS15
16 diarrhea 3, secretory sodium, congenital, with or without other congenital anomalies 12.5
17 diarrhea 4, malabsorptive, congenital 12.4
18 congenital chloride diarrhea 12.4
19 acute diarrhea 12.4
20 diarrhea 6 12.4
21 chronic diarrhea due to guanylate cyclase 2c overactivity 12.3
22 osmotic diarrhea 12.3
23 inflammatory diarrhea 12.3
24 diarrhea 7 12.3
25 congenital diarrhea 7 with exudative enteropathy 12.2
26 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 12.2
27 diarrhea 9 12.1
28 functional diarrhea 12.1
29 motility-related diarrhea 12.1
30 dysentery 12.0
31 diarrhea, chronic, with villous atrophy 12.0
32 secretory diarrhea, myopathy, and deafness 12.0
33 diarrhea, glucose-stimulated secretory, with common variable immunodeficiency 11.9
34 intractable diarrhea-choanal atresia-eye anomalies syndrome 11.9
35 chronic diarrhea due to glucoamylase deficiency 11.9
36 hemolytic uremic syndrome, atypical 1 11.9
37 satoyoshi syndrome 11.8
38 wdha syndrome 11.8
39 vipoma 11.7
40 cholera 11.5
41 irritable bowel syndrome 11.4
42 hemolytic uremic syndrome, atypical 2 11.4
43 hemolytic uremic syndrome, atypical 3 11.4
44 hemolytic uremic syndrome, atypical 4 11.4
45 hemolytic uremic syndrome, atypical 5 11.4
46 hemolytic uremic syndrome, atypical 6 11.4
47 gastroenteritis 11.4
48 shigellosis 11.4
49 collagenous colitis 11.3
50 acrodermatitis enteropathica, zinc-deficiency type 11.3

Graphical network of the top 20 diseases related to Diarrhea:



Diseases related to Diarrhea
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Symptoms & Phenotypes for Diarrhea

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MGI Mouse Phenotypes related to Diarrhea:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.91 DGAT1 EPCAM FOXP3 GUCY2C MYO5B NEUROG3
2 homeostasis/metabolism MP:0005376 9.77 CCK CD40LG DGAT1 EPCAM FOXP3 GUCY2C
3 endocrine/exocrine gland MP:0005379 9.76 CCK CD40LG DGAT1 EPCAM FOXP3 NEUROG3
4 no phenotypic analysis MP:0003012 9.17 ANTXR2 CCK EPCAM FOXP3 NEUROG3 SST
Sources

Drugs & Therapeutics for Diarrhea

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Drugs for Diarrhea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1262)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ceftriaxone Approved Phase 4,Phase 2,Not Applicable 73384-59-5 5479530 5361919
2
Carboprost Tromethamine Approved Phase 4 58551-69-2 45266502 5284525
3
Dexmedetomidine Approved, Vet_approved Phase 4,Not Applicable 113775-47-6 68602 5311068
4
Glyburide Approved Phase 4,Phase 3 10238-21-8 3488
5 Pinaverium Approved Phase 4,Not Applicable 59995-65-2
6
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 7440-66-6
7
leucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58-05-9 6006 143
8
Tocopherol Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 1406-66-2 14986
9
Iron Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 7439-89-6 23925
10
Copper Approved, Investigational Phase 4,Not Applicable 7440-50-8 27099
11
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 73590-58-6 4594
12
Diltiazem Approved, Investigational Phase 4 42399-41-7 39186
13
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable 93-14-1 3516
14
Methadone Approved Phase 4,Phase 3 76-99-3 4095
15
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 657-24-9 14219 4091
16
Exenatide Approved, Investigational Phase 4,Phase 2,Phase 3 141758-74-9 15991534
17
Insulin Glargine Approved Phase 4,Phase 3 160337-95-1
18
Insulin Lispro Approved Phase 4,Phase 3,Phase 2 133107-64-9
19
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 50-78-2 2244
20
Clopidogrel Approved Phase 4 113665-84-2, 120202-66-6 60606
21
Ticlopidine Approved Phase 4 55142-85-3 5472
22
Donepezil Approved Phase 4,Phase 3,Phase 2,Not Applicable 120014-06-4 3152
23
Acetylcholine Approved Phase 4,Phase 2,Not Applicable 51-84-3 187
24
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 26787-78-0 33613
25 Strawberry Approved Phase 4,Phase 3,Phase 2,Not Applicable
26
Bisoprolol Approved Phase 4 66722-44-9 2405
27
Ferrous fumarate Approved Phase 4,Phase 3,Not Applicable 141-01-5
28 lanreotide Approved Phase 4,Phase 2,Phase 3 108736-35-2
29
Somatostatin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 51110-01-1, 38916-34-6 53481605
30
Pasireotide Approved Phase 4,Phase 3,Phase 2 396091-73-9 9941444
31
Octreotide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83150-76-9 383414 6400441
32
Alendronate Approved Phase 4 66376-36-1, 121268-17-5 2088
33
Norepinephrine Approved Phase 4,Phase 3 51-41-2 439260
34
Clonazepam Approved, Illicit Phase 4 1622-61-3 2802
35
Acetylcysteine Approved, Investigational Phase 4,Phase 2 616-91-1 12035
36
Cisplatin Approved Phase 4,Phase 2,Phase 3,Phase 1 15663-27-1 2767 441203 84093
37
Mifepristone Approved, Investigational Phase 4,Not Applicable 84371-65-3 55245
38
Misoprostol Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 59122-46-2 5282381
39
Naproxen Approved, Vet_approved Phase 4 22204-53-1 1302 156391
40
Esomeprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 161796-78-7, 119141-88-7 4594 9579578
41
Celecoxib Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 169590-42-5 2662
42
Naltrexone Approved, Investigational, Vet_approved Phase 4,Phase 3 16590-41-3 5360515
43 tannic acid Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
44
Benzocaine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 94-09-7, 1994-09-7 2337
45
Loperamide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 53179-11-6 3955
46
Zinc sulfate Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 7733-02-0
47
Rifaximin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 80621-81-4 6436173
48
Ondansetron Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 99614-02-5 4595
49
Hydroxocobalamin Approved Phase 4,Phase 3,Phase 2,Not Applicable 13422-51-0 11953898 44475014
50
Nicotinamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 98-92-0 936

Interventional clinical trials:

(show top 50) (show all 3479)
# Name Status NCT ID Phase Drugs
1 Lactobacillus Preparation on the Incidence of Diarrhea Unknown status NCT01792739 Phase 4 Lactobacillus casei variety rhamnosus granules;Placebo
2 Bacillus Particles Prevent Children Antibiotics Associated Diarrhea Unknown status NCT02993419 Phase 4 Bacillus licheniformis Intervention
3 Saccharomyces Boulardii in Diarrhea Dominant Irritable Bowel Syndrome Unknown status NCT00543478 Phase 4 Saccharomyces boulardii;Methyl cellulose powder (low viscosity)
4 Prophylaxis of Gastrointestinal Infections With EcN Unknown status NCT01469273 Phase 4 Mutaflor® Suspension
5 Improving Bowel Habits of Elderly With Probiotics and Non-probiotics Unknown status NCT02949882 Phase 4
6 Lactibiane Tolérance® in Individuals Suffering From Irritable Bowel Syndrome With Diarrheal Predominance Unknown status NCT02728063 Phase 4
7 The Role of Short-course Ceftriaxone Therapy in the Treatment of Severe Nontyphoidal Salmonella Enterocolitis Unknown status NCT01278017 Phase 4 ceftriaxone
8 Anti-inflammatory Effect of Atorvastatin in Atherosclerotic Plaques Assessed by FDG-PET Imaging Unknown status NCT00920101 Phase 4 Atorvastatin
9 Dexmedetomidine on Prevention of Side Effects of Hemabate Unknown status NCT02220361 Phase 4 placebo;low dose dexmedetomidine;high dose dexmedetomidine
10 Long-Term Sulfonylurea Response in ABCC8 Neonatal Diabetes (SuResponsSUR) Unknown status NCT02624830 Phase 4 Sulfonylurea
11 Pinaverium Bromide in Post-cholecystectomy Sphincter of Oddi Dysfunction Unknown status NCT02833103 Phase 4 Danshu Capsules;Pinaverium Bromide
12 The Effect of Probiotics on Exacerbation of Inflammatory Bowel Disease Exacerbation (Crohn's Disease) Unknown status NCT01765998 Phase 4 Probiotic;Placebo
13 Comparison of Enteral Versus Intravenous Potassium Supplementation Unknown status NCT02015962 Phase 4 Intravenous potassium chloride;Oral potassium chloride
14 Effect of Ramosetron on Bowel Motility After Colorectal Resection Unknown status NCT01427127 Phase 4 Ramosetron
15 Strategy to Improve Adherence of Roflumilast Unknown status NCT02018432 Phase 4 Roflumilast escalation dosage;Roflumilast conventional dosage
16 Trial of Captafer® vs. Oral Iron Sulfate in the Treatment of Iron Deficiency Anemia in Patients With IBD Unknown status NCT02774057 Phase 4 Captafer®;Iron Sulfate
17 Randomized, Double Blind, Placebo Control Trial to Evaluate the Efficacy of Wu-Chu-Yu Tang on Gastroesophageal Reflux Disease (GERD) Unknown status NCT01822106 Phase 4
18 Pediatrics Anal Fissures Treatment With Polyethylene Glycol Unknown status NCT02419534 Phase 4 Polyethylene glycol;Polyethylene glycol with Diltiazem
19 Adjunct Methadone to Decrease the Duration of Mechanical Ventilation in the Medical Intensive Care Unit Unknown status NCT02025855 Phase 4 Methadone;Placebo
20 Manipulation of Visceral Sensitivity and Immune System in IBS Unknown status NCT00418340 Phase 4 probiotic (bacterial/dietary supplement)
21 Assessment Of Gh-Igf-1 Axis In Children With Chronic Myelogenous Leukemia (CML) In Remission Unknown status NCT01901666 Phase 4 Growth Hormone
22 Metformin for Weight Control in Adolescents Taking Atypical Antipsychotics Unknown status NCT00845936 Phase 4 Metformin
23 Effect of Exenatide on 24h-UAER in Patients With Diabetic Nephropathy Unknown status NCT02690883 Phase 4 Exenatide;Lispro
24 Safety Study of Enterovirus 71 Vaccine in Children Aged 6-35 Months Old Unknown status NCT02806531 Phase 4
25 The Efficacy of Hydrolyzed Guar Gum ( PHGG) in the Treatment of Patients With Irritable Bowel Syndrome (IBS) Unknown status NCT01779765 Phase 4
26 Medical and Endovascular Treatment of Atherosclerotic Renal Artery Stenosis (METRAS Study) Unknown status NCT01208714 Phase 4 Optimal medical therapy
27 Treatment With Acetyl-Choline Esterase Inhibitors in Children With Autism Spectrum Disorders Unknown status NCT01098383 Phase 4 Acetyl-Choline Esterase Inhibitors and Choline supplements;Indistinguishable placebo tablets, matching both donepezil and choline
28 Middle Meatal Bacteriology During Acute Respiratory Infection in Children Unknown status NCT00545961 Phase 4 placebo;amoxicillin clavulanate acid
29 BRAVE Study With Uncontrolled Essential Hypertension (BRAVE Study) Unknown status NCT02398929 Phase 4 Bisoprolol 2.5 mg;Placebo
30 The Use of Iron Therapy for Patients With Anemia After Surgery Unknown status NCT01975272 Phase 4 Ferinject;Ferrous fumarate;Placebo for ferrous fumarate;Placebo for ferinject
31 Pasireotide LAR and Pegvisomant Study in Acromegaly Unknown status NCT02668172 Phase 4 Pasireotide LAR 60 mg;Pegvisomant
32 Efficacy and Safety of Brand Versus Generic Alendronate for Osteoporosis Treatment Unknown status NCT02371252 Phase 4 Generic alendronate
33 Neurochemical, Metabonomics and Neuroimaging Characterization of TCM Diagnostic Subtypes of Major Depression Disorder Unknown status NCT02346682 Phase 4 venlafaxine
34 THE USE OF N-ACETYLCYSTEINE ATTENUATING CISPLATIN-INDUCED TOXICITIES BY OXIDATIVE STRESS Unknown status NCT02241876 Phase 4 N-acetylcysteine
35 Probiotics in Newly Recognized Type 1 Diabetes Unknown status NCT03032354 Phase 4 Lactobacillus rhamnosus GG and Bifidobacterium lactis BB12
36 Medical Abortion at Gestational Age of 8 to ≤9 Weeks Versus >9 to ≤12 Weeks Unknown status NCT02745093 Phase 4 Mifepristone;Misoprostol
37 Duration of Antibiotic Therapy in Community - Acquired Pneumonia Unknown status NCT01492387 Phase 4
38 Gastro-protective Effect and Pain Relief Effect of Naxozol Compared to Celecoxib in Patients With Osteoarthritis Unknown status NCT02355236 Phase 4 Naproxen/Esomeprazol 500/20mg;Celecoxib 200mg;Naxozol-Placebo;Comparator-Placebo
39 Trial on the Ideal Duration of Oral Antibiotics in Children With Pneumonia Unknown status NCT02258763 Phase 4 Amoxicillin-Potassium Clavulanate Combination;Placebo
40 Pain Relief In Irritable Bowel Syndrome Unknown status NCT02573844 Phase 4 Proklama
41 Low Dose Naltrexone for Treatment of Pain in Patients With Fibromyalgia - Effect Via a Central Mechanism? Unknown status NCT02806440 Phase 4 Low dose naltrexone;Placebo
42 Effects of Probiotics and/or Prebiotics on the Duration of Diarrhea and Hospitalization in Children Completed NCT01927094 Phase 4
43 Community Based Intervention and Evaluation of the Impact of Social Marketing of a Diarrhea Management Pack Completed NCT00942812 Phase 4
44 Lactobacillus Reuteri DSM 17938 in the Prevention of Antibiotic-associated Diarrhea in Children: Protocol of a Randomized Controlled Trial Completed NCT02871908 Phase 4 Lactobacillus reuteri DSM 17938;Placebo
45 Oral Administration of Tannins and Flavonoids in Children With Acute Diarrhea Completed NCT03356327 Phase 4 Actitan F;Standard Oral Rehydration
46 Use of Probiotic Yogurt in the Treatment of Acute Diarrhea in Children Completed NCT01564290 Phase 4 Placebo probiotic
47 Efficacy of Lactobacillus GG With Diosmectite in Treatment Children With Acute Gastroenteritis Completed NCT01657032 Phase 4
48 Preventing Antibiotic-Associated DiarRhea Using Erceflora Completed NCT00447161 Phase 4 Bacillus Clausii Multi ATB Resist;Placebo
49 Azithromycin, With or Without Loperamide, to Treat Travelers' Diarrhea Completed NCT00359970 Phase 4 Azithromycin 500 mg;Azithromycin 1000 mg;Loperamide
50 Efficacy of Racecadotril in Acute Watery Diarrhea in Children Completed NCT01577043 Phase 4 Racecadotril

Search NIH Clinical Center for Diarrhea

Cochrane evidence based reviews: diarrhea

Sources

Genetic Tests for Diarrhea

About this section

Genetic tests related to Diarrhea:

# Genetic test Affiliating Genes
1 Diarrhea 29
Sources

Anatomical Context for Diarrhea

About this section

MalaCards organs/tissues related to Diarrhea:

41
Colon, Breast, Testes, Lung, Kidney, Liver, Prostate
Sources

Publications for Diarrhea

About this section

Articles related to Diarrhea:

(show top 50) (show all 4431)
# Title Authors Year
1
Vitamin A supplementation improves the intestinal mucosal barrier and facilitates the expression of tight junction proteins in rats with diarrhea. ( 30153586 )
2019
2
Detection and differentiation of five diarrhea related pig viruses utilizing a multiplex PCR assay. ( 30336161 )
2019
3
A newly isolated Chinese virulent genotype GIIb porcine epidemic diarrhea virus strain: Biological characteristics, pathogenicity and immune protective effects as an inactivated vaccine candidate. ( 30342075 )
2019
4
MRI findings of metronidazole neurotoxicity in a pediatric patient with chronic diarrhea. ( 30364867 )
2019
5
Acute Diarrhea in an Immunocompromised 55-year-old Man. ( 29549045 )
2018
6
Therapeutic Efficacy of Bumped Kinase Inhibitor 1369 in a Pig Model of Acute Diarrhea Caused by Cryptosporidium hominis. ( 29661877 )
2018
7
Development of a TaqMan-based real-time RT-PCR assay for the detection of SADS-CoV associated with severe diarrhea disease in pigs. ( 29427670 )
2018
8
Cost-effectiveness analysis of telotristat ethyl for treatment of carcinoid syndrome diarrhea inadequately controlled with somatostatin analogs. ( 28959913 )
2018
9
PERIPHERAL RETINAL DRUSEN-LIKE DEPOSITS IN GUCY2C CONGENITAL SECRETORY DIARRHEA SYNDROME. ( 29979251 )
2018
10
Porcine Epidemic Diarrhea Virus and Porcine Deltacoronavirus not Detected in Waterfowl in the North American Mississippi Migratory Flyway in 2013. ( 29953312 )
2018
11
Schistosomiasis in a returning international traveler with cyclic fevers and diarrhea. ( 29449243 )
2018
12
Rotavirus infection among hospitalized children under five years of age with acute watery diarrhea in Sri Lanka. ( 29945833 )
2018
13
Chronic diarrhea: A case of WaldenstrAPm Macroglobulinemia. ( 29463427 )
2018
14
The effect of Clostridium butyricum on symptoms and fecal microbiota in diarrhea-dominant irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial. ( 29445178 )
2018
15
Molecular detection and phylogenetic analysis of human parechovirus in individuals with acute diarrhea and healthy controls in Guangzhou, China. ( 29738080 )
2018
16
Universal recommendations for the management of acute diarrhea in non-malnourished children. ( 29901556 )
2018
17
Incidence of Acute Diarrhea-Associated Death among Children < 5 Years of Age in Bangladesh, 2010-12. ( 29141756 )
2018
18
Primary Prevention of Clostridium difficile-Associated Diarrhea: Current Controversies and Future Tools. ( 29959605 )
2018
19
A rare cause of diarrhea in the occident: A case of colonic schistosomiasis. ( 29887404 )
2018
20
Estimating the distribution of morbidity and mortality of childhood diarrhea, measles, and pneumonia by wealth group in low- and middle-income countries. ( 29970074 )
2018
21
Validation of primer for promoting maternal self-efficacy in preventing childhood diarrhea. ( 29972542 )
2018
22
Stability of Porcine Epidemic Diarrhea Virus on Fomite Materials at Different Temperatures. ( 29438310 )
2018
23
Irritable Bowel Syndrome with predominant diarrhea and giardiasis: is it one or the other? ( 29500067 )
2018
24
Prevalence and Molecular Characterization of<i>Campylobacter</i>spp. Isolated from Patients with Diarrhea in Shunyi, Beijing. ( 29434579 )
2018
25
Analysis of Fecal Primary Bile Acids Detects Increased Stool Weight and Colonic Transit in Patients with Chronic Functional Diarrhea. ( 29902647 )
2018
26
Extracellular Calcium Dictates Onset, Severity, and Recovery of Diarrhea in a Child with Immune-Mediated Enteropathy. ( 29435439 )
2018
27
Epidemiology of acute diarrhea caused by rotavirus in sentinel surveillance sites of Vietnam, 2012-2015. ( 29784467 )
2018
28
Severe Heinz body anemia and methemoglobinemia in a kitten with chronic diarrhea. ( 29615382 )
2018
29
High Rate of Clostridium difficile Among Young Adults Presenting with Diarrhea to Two Hospitals in Kenya. ( 29960098 )
2018
30
Chronic Diarrhea in Common Variable Immunodeficiency: a Case Series and Review of the Literature. ( 29138951 )
2018
31
Clinical Scales for Assessment of Dehydration in Children with Diarrhea: Pediatric Gastroenterologist's Viewpoint. ( 29978820 )
2018
32
Patient-Reported Symptom Control of Diarrhea and Flushing in Patients with Neuroendocrine Tumors Treated with Lanreotide Depot/Autogel: Results from a Randomized, Placebo-Controlled, Double-Blind and 32-Week Open-Label Study. ( 29038234 )
2018
33
Does Bismuth Subgallate Affect Smell and Stool Character? A Randomized Double-Blinded Placebo-Controlled Trial of Bismuth Subgallate on Loop Duodenal Switch Patients with Complaints of Smelly Stools and Diarrhea. ( 29956108 )
2018
34
Diagnostics and Treatments in Chronic Diarrhea and Weight Loss in Horses. ( 29426710 )
2018
35
Construction and immunogenicity analysis of Lactobacillus plantarum expressing a porcine epidemic diarrhea virus S gene fused to a DC-targeting peptide. ( 29288673 )
2018
36
The other Campylobacters: Not innocent bystanders in endemic diarrhea and dysentery in children in low income settings. ( 29415075 )
2018
37
Altered Intestinal Microbiota with Increased Abundance of <i>Prevotella</i> Is Associated with High Risk of Diarrhea-Predominant Irritable Bowel Syndrome. ( 29967640 )
2018
38
An Integrated Approach to Control Soil-Transmitted Helminthiasis, Schistosomiasis, Intestinal Protozoa Infection, and Diarrhea: Protocol for a Cluster Randomized Trial. ( 29895511 )
2018
39
A traumatic hepatic artery pseudoaneurysm and arterioportal fistula, with severe diarrhea as the first symptom: A case report and review of the literature. ( 29443759 )
2018
40
Short communication: Calf cleanliness does not predict diarrhea upon arrival at a veal calf facility. ( 29428765 )
2018
41
Congenital chloride diarrhea needs to be distinguished from Bartter and Gitelman syndrome. ( 29849040 )
2018
42
Clinical Scales for Assessment of Dehydration in Children with Diarrhea: Pediatrician's Viewpoint. ( 29978821 )
2018
43
Bta-miR-2411 attenuates bovine viral diarrhea virus replication via directly suppressing Pelota protein in Madin-Darby bovine kidney cells. ( 29426405 )
2018
44
Efficacy of heat-labile enterotoxin B subunit-adjuvanted parenteral porcine epidemic diarrhea virus trimeric spike subunit vaccine in piglets. ( 29961099 )
2018
45
Peptide inhibitors of chloride channels for treating secretory diarrhea. ( 29772528 )
2018
46
Efficacy and safety of Modified Tongxie Yaofang in diarrhea-predominant irritable bowel syndrome management: A meta-analysis of randomized, positive medicine-controlled trials. ( 29408906 )
2018
47
Nucleocapsid protein from porcine epidemic diarrhea virus isolates can antagonize interferon-I> production by blocking the nuclear factor-I_B nuclear translocation. ( 29971995 )
2018
48
Cost utility, budget impact, and scenario analysis of racecadotril in addition to oral rehydration for acute diarrhea in children in Malaysia. ( 29588606 )
2018
49
Complete Genome Sequence of a Recombinant Porcine Epidemic Diarrhea Virus Strain, CH/JXJA/2017, Isolated in Jiangxi, China, in 2017. ( 29439052 )
2018
50
Diarrhea Prevalence and Sociodemographic Factors among Under-Five Children in Rural Areas of North Gondar Zone, Northwest Ethiopia. ( 29971113 )
2018
Sources

Variations for Diarrhea

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ClinVar genetic disease variations for Diarrhea:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 WNT2B NM_024494.2(WNT2B): c.205C> T (p.Arg69Ter) single nucleotide variant Pathogenic rs370244148 GRCh37 Chromosome 1, 113057518: 113057518
2 WNT2B NM_024494.2(WNT2B): c.205C> T (p.Arg69Ter) single nucleotide variant Pathogenic rs370244148 GRCh38 Chromosome 1, 112514896: 112514896
Sources

Expression for Diarrhea

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Search GEO for disease gene expression data for Diarrhea.
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Pathways for Diarrhea

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Pathways related to Diarrhea according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers 65
10.92 EPCAM NEUROG3 WNT2B
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GO Terms for Diarrhea

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Cellular components related to Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 9.46 EPCAM SI SLC26A3 SLC9A3
2 Ski complex GO:0055087 8.96 SKIV2L TTC37
3 brush border GO:0005903 8.92 MME SI SLC9A3 TMPRSS15
4 integral component of membrane GO:0016021 10.03 ANTXR2 CD40LG CYP3A4 DGAT1 EPCAM GUCY2C

Biological processes related to Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA catabolic process GO:0006401 9.16 SKIV2L TTC37
2 positive regulation of interleukin-4 production GO:0032753 8.96 CD40LG FOXP3
3 digestion GO:0007586 8.8 CCK GUCY2C SST
Sources

Sources for Diarrhea

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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