MCID: DRR001
MIFTS: 55

Diarrhea

Categories: Gastrointestinal diseases, Genetic diseases, Infectious diseases, Nephrological diseases, Oral diseases, Rare diseases

Aliases & Classifications for Diarrhea

MalaCards integrated aliases for Diarrhea:

Name: Diarrhea 12 29 6 42 15 39
Diarrhoea 12 15
Diarrhea of Presumed Infectious Origin 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13250
ICD9CM 34 009.2
MeSH 44 D004403
SNOMED-CT 67 154268000
UMLS 70 C0013369

Summaries for Diarrhea

MedlinePlus : 42 What is diarrhea? Diarrhea is loose, watery stools (bowel movements). You have diarrhea if you have loose stools three or more times in one day. Acute diarrhea is diarrhea that lasts a short time. It is a common problem. It usually lasts about one or two days, but it may last longer. Then it goes away on its own. Diarrhea lasting more than a few days may be a sign of a more serious problem. Chronic diarrhea -- diarrhea that lasts at least four weeks -- can be a symptom of a chronic disease. Chronic diarrhea symptoms may be continual, or they may come and go. What causes diarrhea? The most common causes of diarrhea include Bacteria from contaminated food or water Viruses such as the flu, norovirus, or rotavirus . Rotavirus is the most common cause of acute diarrhea in children. Parasites, which are tiny organisms found in contaminated food or water Medicines such as antibiotics, cancer drugs, and antacids that contain magnesium Food intolerances and sensitivities, which are problems digesting certain ingredients or foods. An example is lactose intolerance. Diseases that affect the stomach, small intestine, or colon, such as Crohn's disease Problems with how the colon functions, such as irritable bowel syndrome Some people also get diarrhea after stomach surgery, because sometimes the surgeries can cause food to move through your digestive system more quickly. Sometimes no cause can be found. If your diarrhea goes away within a few days, finding the cause is usually not necessary. Who is at risk for diarrhea? People of all ages can get diarrhea. On average, adults In the United States have acute diarrhea once a year. Young children have it an average of twice a year. People who visit developing countries are at risk for traveler's diarrhea. It is caused by consuming contaminated food or water. What other symptoms might I have with diarrhea? Other possible symptoms of diarrhea include Cramps or pain in the abdomen An urgent need to use the bathroom Loss of bowel control If a virus or bacteria is the cause of your diarrhea, you may also have a fever, chills, and bloody stools. Diarrhea can cause dehydration, which means that your body does not have enough fluid to work properly. Dehydration can be serious, especially for children, older adults, and people with weakened immune systems. When do I need to see a health care provider for diarrhea? Although it is usually not harmful, diarrhea can become dangerous or signal a more serious problem. Contact your health care provider if you have Signs of dehydration Diarrhea for more than 2 days, if you are an adult. For children, contact the provider if it lasts more than 24 hours. Severe pain in your abdomen or rectum (for adults) A fever of 102 degrees or higher Stools containing blood or pus Stools that are black and tarry If children have diarrhea, parents or caregivers should not hesitate to call a health care provider. Diarrhea can be especially dangerous in newborns and infants. How is the cause of diarrhea diagnosed? To find the cause of diarrhea, your health care provider may Do a physical exam Ask about any medicines you are taking Test your stool or blood to look for bacteria, parasites, or other signs of disease or infection Ask you to stop eating certain foods to see whether your diarrhea goes away If you have chronic diarrhea, your health care provider may perform other tests to look for signs of disease. What are the treatments for diarrhea? Diarrhea is treated by replacing lost fluids and electrolytes to prevent dehydration. Depending on the cause of the problem, you may need medicines to stop the diarrhea or treat an infection. Adults with diarrhea should drink water, fruit juices, sports drinks, sodas without caffeine, and salty broths. As your symptoms improve, you can eat soft, bland food. Children with diarrhea should be given oral rehydration solutions to replace lost fluids and electrolytes. Can diarrhea be prevented? Two types of diarrhea can be prevented - rotavirus diarrhea and traveler's diarrhea. There are vaccines for rotavirus. They are given to babies in two or three doses. You can help prevent traveler's diarrhea by being careful about what you eat and drink when you are in developing countries: Use only bottled or purified water for drinking, making ice cubes, and brushing your teeth If you do use tap water, boil it or use iodine tablets Make sure that the cooked food you eat is fully cooked and served hot Avoid unwashed or unpeeled raw fruits and vegetables NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Diarrhea, also known as diarrhoea, is related to diarrhea 2, with microvillus atrophy and diarrhea 5, with tufting enteropathy, congenital. An important gene associated with Diarrhea is WNT2B (Wnt Family Member 2B), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Bile secretion. The drugs Acetylcholine and Donepezil have been mentioned in the context of this disorder. Affiliated tissues include colon, breast and small intestine, and related phenotypes are digestive/alimentary and homeostasis/metabolism

Disease Ontology : 12 A gastrointestinal system disease described as the condition of having frequent loose or liquid bowel movements. Acute diarrhea is a common cause of death in developing countries and the second most common cause of infant deaths worldwide. The loss of fluids through diarrhea can cause severe dehydration which is one cause of death in diarrhea sufferers. Along with water, sufferers also lose dangerous amounts of important salts, electrolytes, and other nutrients. There are at least four types of diarrhea: secretory diarrhea, osmotic diarrhea, motility-related diarrhea, and inflammatory diarrhea.

Wikipedia : 73 Diarrhea, also spelled diarrhoea, is the condition of having at least three loose, liquid, or watery... more...

Related Diseases for Diarrhea

Diseases in the Diarrhea family:

Diarrhea 6 Diarrhea 9
Chronic Diarrhea Due to Guanylate Cyclase 2c Overactivity Inflammatory Diarrhea
Acute Diarrhea Congenital Diarrhea

Diseases related to Diarrhea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1390)
# Related Disease Score Top Affiliating Genes
1 diarrhea 2, with microvillus atrophy 33.3 TTC37 SLC9A3 SLC26A3 MYO5B
2 diarrhea 5, with tufting enteropathy, congenital 33.3 TTC37 SPINT2 SLC9A3 SLC26A3 NEUROG3 MYO5B
3 diarrhea 3, secretory sodium, congenital, with or without other congenital anomalies 33.2 SPINT2 SLC9A3 GUCY2C
4 diarrhea 1, secretory chloride, congenital 33.2 SLC9A3 SLC26A3
5 diarrhea 4, malabsorptive, congenital 33.1 TTC37 NEUROG3 MYO5B
6 diarrhea 8, secretory sodium, congenital 33.0 SLC9A3 MYO5B
7 secretory diarrhea 32.9 SST SPINT2 SLC9A3 SLC26A3 MYO5B GUCY2C
8 osmotic diarrhea 32.9 WNT2B SLC9A3 SLC26A3 MGAM
9 acute diarrhea 32.8 SLC9A3 MME
10 congenital diarrhea 32.8 TTC37 SPINT2 SLC9A3 SLC26A3 NEUROG3 MYO5B
11 inflammatory diarrhea 32.7 SLC9A3 SLC26A3
12 sucrase-isomaltase deficiency, congenital 32.0 SI MGAM
13 mucopolysaccharidosis iii 31.7 SI SGSH MGAM
14 serotonin syndrome 31.6 SST CYP3A4
15 ileus 31.1 SST SLC9A3 GUCY2C
16 volvulus of midgut 30.6 SST GUCY2C
17 nasopharyngitis 30.4 SI MGAM CYP3A4
18 spermatocele 30.3 SLC9A3 SLC26A3
19 mucopolysaccharidosis-plus syndrome 30.2 SI SGSH MGAM
20 cerebral lymphoma 30.2 SST MME
21 postgastrectomy syndrome 30.2 SST SI MGAM
22 pneumatosis cystoides intestinalis 30.2 SI MGAM
23 scheie syndrome 30.1 SI SGSH MGAM
24 proprotein convertase 1/3 deficiency 30.0 NEUROG3 MYO5B
25 trichohepatoenteric syndrome 1 11.7
26 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 11.6
27 congenital chloride diarrhea 11.6
28 dysentery 11.5
29 diarrhea 6 11.5
30 diarrhea 11, malabsorptive, congenital 11.5
31 diarrhea 9 11.4
32 diarrhea 10, protein-losing enteropathy type 11.4
33 chronic diarrhea due to guanylate cyclase 2c overactivity 11.4
34 congenital diarrhea 7 with exudative enteropathy 11.3
35 hemolytic uremic syndrome, atypical 1 11.3
36 cholera 11.3
37 irritable bowel syndrome 11.3
38 gastroenteritis 11.3
39 satoyoshi syndrome 11.3
40 pancreatic cholera 11.3
41 vipoma 11.2
42 diarrhea 7, protein-losing enteropathy type 11.2
43 motility-related diarrhea 11.2
44 functional diarrhea 11.2
45 cryptosporidiosis 11.2
46 glucose/galactose malabsorption 11.2
47 shigellosis 11.1
48 celiac disease 1 11.1
49 salmonellosis 11.1
50 lactose intolerance 11.1

Graphical network of the top 20 diseases related to Diarrhea:



Diseases related to Diarrhea

Symptoms & Phenotypes for Diarrhea

MGI Mouse Phenotypes related to Diarrhea:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.65 DGAT1 EPCAM FOXP3 GUCY2C MYO5B NEUROG3
2 homeostasis/metabolism MP:0005376 9.44 DGAT1 EPCAM FOXP3 GUCY2C MGAM MME

Drugs & Therapeutics for Diarrhea

Drugs for Diarrhea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 425)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
2
Donepezil Approved Phase 4 120014-06-4 3152
3
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
4
Zinc sulfate Approved, Investigational Phase 4 7733-02-0
5
Azithromycin Approved Phase 4 83905-01-5 447043 55185
6
Curcumin Approved, Experimental, Investigational Phase 4 458-37-7 969516
7
Turmeric Approved, Experimental, Investigational Phase 4
8
Ondansetron Approved Phase 4 99614-02-5 4595
9
chenodeoxycholic acid Approved Phase 4 474-25-9 10133
10
Nicotinamide Approved, Investigational Phase 4 98-92-0 936
11
Copper Approved, Investigational Phase 4 7440-50-8 27099
12
Methylcobalamin Approved, Investigational Phase 4 13422-55-4
13
Hydroxocobalamin Approved Phase 4 13422-51-0 11953898 15589840
14
Iodine Approved, Investigational Phase 4 7553-56-2 807
15
Tocopherol Approved, Investigational Phase 4 1406-66-2
16
Acarbose Approved, Investigational Phase 4 56180-94-0 441184
17
Pemetrexed Approved, Investigational Phase 4 150399-23-8, 137281-23-3 60843 446556
18
Insulin aspart Approved Phase 4 116094-23-6 16132418
19
Simethicone Approved Phase 4 8050-81-5
20
Sodium citrate Approved, Investigational Phase 4 68-04-2
21
Alosetron Approved, Withdrawn Phase 4 122852-42-0 2099
22
Tegaserod Approved, Investigational, Withdrawn Phase 4 189188-57-6, 145158-71-0 122724
23
Ferrous fumarate Approved Phase 4 141-01-5
24
Sulfamethoxazole Approved Phase 4 723-46-6 5329
25
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
26
Metformin Approved Phase 4 657-24-9 4091 14219
27
Salmon calcitonin Approved, Investigational Phase 4 47931-85-1 16129616
28
Lactulose Approved Phase 4 4618-18-2 11333
29
Levoleucovorin Approved, Investigational Phase 4 68538-85-2 149436
30
Clotrimazole Approved, Vet_approved Phase 4 23593-75-1 2812
31
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
32
Bismuth subsalicylate Approved, Vet_approved Phase 4 14882-18-9 53629521
33
Fidaxomicin Approved Phase 4 873857-62-6
34
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
35
Posaconazole Approved, Investigational, Vet_approved Phase 4 171228-49-2 147912
36
Teicoplanin Approved, Investigational Phase 4 61036-62-2
37
Ursodeoxycholic acid Approved, Investigational Phase 4 128-13-2 31401
38
Tacrolimus Approved, Investigational Phase 4 104987-11-3 6473866 445643 439492
39
Mycophenolic acid Approved Phase 4 24280-93-1 446541
40
Metronidazole Approved Phase 4 443-48-1 4173
41
Choline Approved, Nutraceutical Phase 4 62-49-7 305
42
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 5280795 6221
43
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
44
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
45
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
46
Niacin Approved, Investigational, Nutraceutical Phase 4 59-67-6 938
47
Cyanocobalamin Approved, Nutraceutical Phase 4 68-19-9 44176380
48
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 4 70-16-6, 59-43-8 1130
49
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 4 83-88-5 493570
50
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 4 65-23-6 1054

Interventional clinical trials:

(show top 50) (show all 870)
# Name Status NCT ID Phase Drugs
1 Treatment Effect of Colesevelam for Bile Acid Diarrhoea - a Randomised Placebo-controlled Trial Unknown status NCT03876717 Phase 4 Colesevelam Hydrochloride;Placebo oral capsule
2 Changes in Microbiota and Metabolomic Profile Between Rifaximin Responders and Non-responders In Diarrhoea-Predominant Irritable Bowel Syndrome Unknown status NCT03557788 Phase 4 Rifaximin Oral Tablet
3 Prophylaxis of Gastrointestinal Infections in Newborn and Infants With a Suspension Containing the Probiotic Escherichia Coli Strain Nissle Unknown status NCT01469273 Phase 4 Mutaflor® Suspension
4 Treatment With Acetyl-Choline Esterase Inhibitors in Children With Autism Unknown status NCT01098383 Phase 4 Acetyl-Choline Esterase Inhibitors and Choline supplements;Indistinguishable placebo tablets, matching both donepezil and choline
5 The Impact of Lactobacillus Preparation on the Incidence of Diarrhea in Intensive Care Unit-admitted Patients : Randomized Controlled Trial Unknown status NCT01792739 Phase 4 Lactobacillus casei variety rhamnosus granules;Placebo
6 Bacillus Particles Prevent More Children's Antibiotic-associated Diarrhea (AAD), Randomized, Double-blind, Controlled Clinical Trial Unknown status NCT02993419 Phase 4 Bacillus licheniformis Intervention
7 The Role of Short-course Ceftriaxone Therapy in the Treatment of Severe Nontyphoidal Salmonella Enterocolitis Unknown status NCT01278017 Phase 4 ceftriaxone
8 Comparing a Probiotic and Non-probiotic Intervention in Their Ability to Improve Bowel Habits of Residents in Nursing Homes Unknown status NCT02949882 Phase 4
9 Role Of Saccharomyces Boulardii In Diarrhea Dominant Irritable Bowel Syndrome Unknown status NCT00543478 Phase 4 Saccharomyces boulardii;Methyl cellulose powder (low viscosity)
10 Non-specific Effects of Rabies Vaccine on the Incidence of Common Infectious Disease Episodes: a Randomized Controlled Trial Unknown status NCT03656198 Phase 4 Sterile Water Injection
11 Efficacy and Mode of Action of Mesalazine in the Treatment of Diarrhoea-predominant Irritable Bowel Syndrome (IBS-D). Completed NCT01316718 Phase 4 Mesalazine;Placebo
12 Rapid Diagnostics and Probiotic Therapy for Paediatric Acute Gastroenteritis - a Randomized, Factorial, Controlled, Placebo-controlled, Pilot Trial Completed NCT02025452 Phase 4
13 STOP Trial - Sandostatin LAR Depot Trial for the Optimum Prevention of Chemotherapy Induced Diarrhea Completed NCT00050635 Phase 4 Sandostatin LAR Depot
14 Vitamin A and Zinc: Prevention of Pneumonia (VAZPOP) Study Completed NCT00228254 Phase 4 Zinc (12.5 mg/day);vitamin A 10,000 IU per week
15 Post-marketing Clinical Study of Ramosetron Hydrochloride (Irribow Tablets) - Double-blind, Parallel-group Comparative Study in Patients (Male) With Diarrhea-predominant Irritable Bowel Syndrome Completed NCT01225237 Phase 4 Ramosetron;Placebo
16 Efficacy and Safety of a New Oral Rehydration Solution (Hipp ORS 200 Apple) in Children With Acute Gastroenteritis: Randomized, Double-Blind Controlled Trial Completed NCT01467570 Phase 4
17 Delivery of Iron and Zinc Supplements: Evaluation of Interaction Effect on Biochemical and Clinical Outcomes Completed NCT00470158 Phase 4
18 Efficacy of Lactobacillus GG With Diosmectite in Treatment Children With Acute Gastroenteritis: A Double Blind Randomized, Placebo- Controlled Trial Completed NCT01657032 Phase 4
19 Study Title: Curcumin (Tumeric) in the Treatment of Irritable Bowel Syndrome: A Randomized-Controlled Trial Completed NCT00779493 Phase 4
20 Post-marketing Clinical Study of Ramosetron Hydrochloride (Irribow Tablets) - A Preliminary Study to Evaluate the Co-primary Endpoint in Patients (Male) With Diarrhea-predominant Irritable Bowel Syndrome Completed NCT00918411 Phase 4 Ramosetron;Placebo
21 Efficacy of Diosmectite (Smecta®) in the Treatment of Acute Diarrhoea in Adults. A Multicentre, Randomised, Double Blind, Placebo Controlled, Parallel Groups Study. Completed NCT00276328 Phase 4 Diosmectite (Smecta®)
22 Introduction of New Hypo-osmolar ORS Into Routine Use in the Management of Diarrhoeal Disease: a Phase IV Clinical Surveillance. Completed NCT00244777 Phase 4 Hypo-osmolar ORS
23 Efficacy of Diosmectite (Smecta®) in the Symptomatic Treatment of Acute Diarrhoea in Adults. A Multicentre, Randomized, Double Blind Placebo Controlled, Parallel, Groups Study Completed NCT02704091 Phase 4 Smecta;Smecta placebo
24 Ondansetron for the Treatment of IBS With Diarrhoea (IBS-D): Identifying the "Responder" Completed NCT00745004 Phase 4 Ondansetron;Placebo
25 Validation of Stimulated ∆FGF19 for Diagnosing Bile Acid Diarrhoea Completed NCT03059537 Phase 4 Oral chenodeoxycholic acid stimulation
26 Mode of Action of Ondansetron, a 5-HT Receptor 3 Antagonist, in Lactulose Induced Diarrhoea Completed NCT03833999 Phase 4 Ondansetron 8mg;Lactulose;Placebo oral capsule
27 A Randomised Placebo Controlled Trial of "Follow on" Rifaximin for the Prevention of Relapse of Clostridium Associated Diarrhoea Completed NCT01670149 Phase 4 Rifaximin;Placebo
28 Effect of Lactobacillus Reuteri DSM 17938 to Prevent Antibiotic-associated Diarrhea in Children: Prospective, Multi-center, Randomize, Parallel Group Placebo Controlled Clinical Trial Completed NCT02765217 Phase 4 Lactobacillus reuteri DSM 17938;Placebo;Amoxicillin-Clavulanic Acid
29 The Effect of a Probiotic and/or Prebiotic on the Duration of Diarrhea and Length of Hospital Stay in Children With Acute Diarrhea: Prospective, Double Blind, Randomized Controlled Trial Completed NCT01927094 Phase 4
30 A Community Based Intervention and Evaluation of the Impact of Social Marketing of a Diarrhea Management Pack(Comprising of Low Osmolality ORS, Zinc Tablets, Water Purification Tablets and Pictorial Chart) on Childhood Diarrhea. Completed NCT00942812 Phase 4
31 Bacillus Clausii in Preventing Antibiotic-Associated Diarrhea Among Filipino Infant and Children: A Multi-Center, Randomized, Open-Label Controlled (Treatment vs No Treatment) Clinical Trial of Efficacy and Safety Completed NCT00447161 Phase 4 Bacillus Clausii Multi ATB Resist;Placebo
32 Effect of Acarbose on Postprandial Lipoprotein Levels in Glucose Intolerant Patients Completed NCT02355509 Phase 4 Acarbose;Placebo
33 Open-Label Single-Arm Phase IV Study of Pemetrexed in Taiwanese Patients With Advanced Non-Small Cell Lung Cancer Who Have Had Prior Chemotherapy Completed NCT00380718 Phase 4 pemetrexed
34 Oral Administration of Tannins and Flavonoids in Children With Acute Diarrhea : A Pilot, Randomized, Control-case Study Completed NCT03356327 Phase 4 Actitan F;Standard Oral Rehydration
35 The Effect of Berberine on Intestinal Function and Inflammatory Mediators in Severe Patients With Covid-19 Completed NCT04479202 Phase 4 Berberine;Montmorrillonite
36 Comparison of Efficacy and Safety of Prandilin and NovoRapid Evaluated by Continuous Glucose Monitoring System in Newly Diagnosed Type 2 Diabetes Completed NCT03226210 Phase 4 aspart insulin or lipro insulin
37 Loperamide Plus Azithromycin More Effectively Treats Travelers' Diarrhea In Mexico Than Azithromycin Alone Completed NCT00359970 Phase 4 Azithromycin 500 mg;Azithromycin 1000 mg;Loperamide
38 Postmarketing Study of Probiotics Medication in Childhood Diarrhea Completed NCT00463190 Phase 4 Biothree
39 Rifaximin in Standard Three-Day Dosing With and Without the Antimotility Drug, Loperamide, in the Treatment of Travelers' Diarrhea Completed NCT00292344 Phase 4 Rifaximin and loperamide
40 Effect of Zinc Sulphate and Zinc Amino Acid Chelate in Prevention Acute Diarrhea and Acute Respiratory Infection, Medellín 2012 Completed NCT01791608 Phase 4
41 Introduction of New Hypo-Osmolar ORS (Recommended by WHO) for Routine Use in the Management of Diarrhoeal Diseases - A Phase IV Surveillance Study Completed NCT00490932 Phase 4 Hypo-osmolar ORS
42 An Evaluation of the Immune Response to Pentavalent Rotavirus Vaccine After a Supplemental Dose Given at 9 Months of Age With Local EPI Vaccines in Mali Completed NCT02286895 Phase 4
43 A Phase 4 Multicenter, Multinational, Prospective, Randomized, Placebo-Controlled, Double-Blinded Parallel Group Study to Assess Efficacy of Eluxadoline in the Treatment of Irritable Bowel Syndrome With Diarrhea (IBS-D) in Patients Who Report Inadequate Control of IBS-D Symptoms With Prior Loperamide Use (RELIEF) Completed NCT02959983 Phase 4 Eluxadoline;Placebo
44 Phase 4 Study of Probiotics on Intestinal Bacterial Population and Immune Modulation Completed NCT00763399 Phase 4
45 Efficacy of Racecadotril in the Management of Acute Watery Diarrhea in Children Completed NCT01577043 Phase 4 Racecadotril
46 Lactobacillus Reuteri DSM 17938 in the Prevention of Antibiotic-associated Diarrhea in Children: Protocol of a Randomized Controlled Trial Completed NCT02871908 Phase 4 Lactobacillus reuteri DSM 17938;Placebo
47 Lactobacillus Casei e Bifidobacterium Breve as Probiotics at the Treatment of Antibiotic Associated Diarrhea: a Randomized Double Blind Study Completed NCT00700557 Phase 4
48 Use of Probiotic Yogurt in the Treatment of Acute Diarrhea in Children: A Randomized Double-blind Trial Completed NCT01564290 Phase 4 Placebo probiotic
49 A Randomized, Parallel Group Comparison of Loperamide/Simeticone Caplet, Loperamide/Simeticone Chewable Tablet (IMODIUM® PLUS) and a Probiotic (Saccharomyces Boulardii) in the Treatment of Acute Diarrhea in Adults Completed NCT00807326 Phase 4 Loperamide/simeticone 2 mg/125 mg caplets;Loperamide/simeticone 2 mg/125 mg chewable tablets;Probiotic Saccharomyces boulardii 250 mg capsules
50 3030-401-002: An Open-Label Pilot Study of Eluxadoline in Participants With Irritable Bowel Syndrome With Diarrhea (IBS-D) Who Have Evidence of Bile Acid Malabsorption (BAM) Completed NCT03441581 Phase 4 Eluxadoline

Search NIH Clinical Center for Diarrhea

Genetic Tests for Diarrhea

Genetic tests related to Diarrhea:

# Genetic test Affiliating Genes
1 Diarrhea 29

Anatomical Context for Diarrhea

MalaCards organs/tissues related to Diarrhea:

40
Colon, Breast, Small Intestine, Thyroid, Prostate, Skin, Bone Marrow

Publications for Diarrhea

Articles related to Diarrhea:

(show top 50) (show all 57460)
# Title Authors PMID Year
1
Intestinal protozoa in hospitalized under-five children with diarrhoea in Nampula - a cross-sectional analysis in a low-income setting in northern Mozambique. 61 42
33622284 2021
2
A comparison of two multiplex-PCR assays for the diagnosis of traveller's diarrhoea. 61 42
33593278 2021
3
Whole-genome sequencing of patients with rare diseases in a national health system. 6
32581362 2020
4
The prognostic value of comorbidity for the severity of COVID-19: A systematic review and meta-analysis study. 42
33592019 2021
5
Comparative effectiveness of lactulose and sennosides for the prevention of peritoneal dialysis-related peritonitis: an open-label, randomized, active-controlled trial. 61
33596746 2021
6
Sauropus brevipes ethanol extract negatively regulates inflammatory responses in vivo and in vitro by targeting Src, Syk and IRAK1. 61
33439064 2021
7
Attenuation of porcine deltacoronavirus disease severity by porcine reproductive and respiratory syndrome virus coinfection in a weaning pig model. 61
33797313 2021
8
Comprehensive analysis of lncRNA expression profiles in cytopathic biotype BVDV-infected MDBK cells provides an insight into biological contexts of host-BVDV interactions. 61
33258421 2021
9
Antimicrobial resistance and gene regulation in Enteroaggregative Escherichia coli from Egyptian children with diarrhoea: Similarities and differences. 61
33372849 2021
10
Infection of polarized bovine respiratory epithelial cells by bovine viral diarrhea virus (BVDV). 61
33300445 2021
11
Dynamic Dissection of Dynein and Kinesin-1 Cooperatively Mediated Intercellular Transport of Porcine Epidemic Diarrhea Coronavirus along Microtubule Using Single Virus Tracking. 61
33538234 2021
12
Berberine regulates the Notch1/PTEN/PI3K/AKT/mTOR pathway and acts synergistically with 17-AAG and SAHA in SW480 colon cancer cells. 61
33417512 2021
13
Prospect of microbial food borne diseases in Pakistan: a review. 61
33605364 2021
14
Anti-inflammatory effects of Radix Aucklandiae herbal preparation ameliorate intestinal mucositis induced by 5-fluorouracil in mice. 61
33567307 2021
15
Gastrointestinal manifestations of COVID-19: results from a European centre. 61
33787540 2021
16
Protective effects of curcumin against rat intestinal inflammation‑related motility disorders. 61
33760185 2021
17
Phase I trial of the MEK inhibitor selumetinib in combination with thoracic radiotherapy in non-small cell lung cancer. 61
33748440 2021
18
Infectious diseases affecting the small bowel - what not to miss. 61
33769379 2021
19
Diarrhoea in adults with coronavirus disease-beyond incidence and mortality: a systematic review and meta-analysis. 61
33583306 2021
20
Distinct diarrhea profiles during outpatient chemotherapy. 61
32918132 2021
21
Atractylodes oil alleviates diarrhea-predominant irritable bowel syndrome by regulating intestinal inflammation and intestinal barrier via SCF/c-kit and MLCK/MLC2 pathways. 61
33592255 2021
22
Effect of bovine viral diarrhea virus on subsequent infectivity of bovine gammaherpesvirus 4 in endometrial cells in primary culture: An in vitro model of viral co-infection. 61
33600847 2021
23
Effects of 10.6-μm laser moxibustion and electroacupuncture at ST36 in a 5-Fu-induced diarrhea rat model. 61
32959156 2021
24
Antibiotic and medical zinc oxide usage in Danish conventional and welfare-label pig herds in 2016-2018. 61
33556801 2021
25
Aquaporin: targets for dietary nutrients to regulate intestinal health. 61
33811387 2021
26
Dietary copper/zinc-loaded montmorillonite improved growth performance and intestinal barrier and changed gut microbiota in weaned piglets. 61
33793003 2021
27
Determinants and patterns of antibiotic consumption for children under five in Nepal: analysis and modelling of Demographic Health Survey data from 2006 to 2016. 61
33338311 2021
28
Mechanisms of antidiarrhoeal activity of methanol leaf extract of Combretum hypopilinum diels (combretaceae): Involvement of opioidergic and (α1 and β)-adrenergic pathways. 61
33359856 2021
29
Clinical Presentation in Children With Coeliac Disease in Central Europe. 61
33306584 2021
30
Safety and immunogenicity of a synthetic carbohydrate conjugate vaccine against Shigella flexneri 2a in healthy adult volunteers: a phase 1, dose-escalating, single-blind, randomised, placebo-controlled study. 61
33186516 2021
31
Giardia intestinalis can interact, change its shape and internalize large particles and microorganisms. 61
33280628 2021
32
Repurposing of some anti-infective drugs for COVID-19 treatment: A surveillance study supported by an in silico investigation. 61
33300221 2021
33
A case of Cerebrotendinous Xanthomatosis with spinal cord involvement and without tendon xanthomas: identification of a new mutation of the CYP27A1 gene. 61
31875301 2021
34
TMEM16A deficiency: a potentially fatal neonatal disease resulting from impaired chloride currents. 61
32487539 2021
35
One-step differential detection of Salmonella enterica serovar Typhi, serovar Paratyphi A and other Salmonella spp. by using a quadruplex real-time PCR assay. 61
33662480 2021
36
Acute mesenteric ischaemia due to superior mesenteric vein (SMV) thrombosis. 61
33795268 2021
37
Environmental reservoirs of Vibrio cholerae serogroups in the flowing freshwater environs from the tribal areas of Odisha, Eastern India. 61
33264464 2021
38
[Intestinal lymphangiectasia in a patient with Sanfilippo B syndrome]. 61
33749204 2021
39
Clinical and laboratory features associated with mortality in children with severe malnutrition in Papua New Guinea. 61
33797342 2021
40
Effects of Taraxacum and Astragalus extracts combined with probiotic Bacillus subtilis and Lactobacillus on Escherichia coli-infected broiler chickens. 61
33647724 2021
41
Microbiological Survey of Wheat Flour Sold at Retail in Canada, 2018 to 2019. 61
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Effects of Zinc Oxide/Zeolite on Intestinal Morphology, Intestinal Microflora, and Diarrhea Rates in Weaned Piglets. 61
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Expansion of the ophthalmic phenotype of SPINT2-related syndromic congenital sodium diarrhea. 61
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Identification and genotyping of a new subtype of bovine viral diarrhea virus 1 isolated from cattle with diarrhea. 61
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Irinotecan and temozolomide chemotherapy in paediatric and adult populations with relapsed Ewing Sarcoma. 61
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Effectiveness of liraglutide 3 mg for the treatment of obesity in a real-world setting without intensive lifestyle intervention. 61
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Efficacy and safety of 0.0584% hydrocortisone aceponate topical spray and systemic oclacitinib combination therapy in dogs with atopic dermatitis: a randomized, double-blinded, placebo-controlled trial. 61
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Predictors of increased melphalan exposure correlate with overall survival, nonrelapse mortality, and toxicities in patients undergoing reduced-intensity allogeneic stem cell transplantation with fludarabine and melphalan. 61
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Reactive arthritis: an unusual presentation of acute Clostridioides difficile colitis. 61
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Pharmacologycal activity of peperina (Minthostachys verticillata) on gastrointestinal tract. 61
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Variations for Diarrhea

ClinVar genetic disease variations for Diarrhea:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 WNT2B NM_024494.3(WNT2B):c.205C>T (p.Arg69Ter) SNV Pathogenic 545432 rs370244148 GRCh37: 1:113057518-113057518
GRCh38: 1:112514896-112514896
2 SGSH NM_000199.5(SGSH):c.1272_1282del (p.Tyr424_Arg428delinsTer) Deletion Pathogenic 287037 rs752914124 GRCh37: 17:78184478-78184488
GRCh38: 17:80210679-80210689
3 SGSH NM_000199.5(SGSH):c.892T>C (p.Ser298Pro) SNV Pathogenic 30459 rs138504221 GRCh37: 17:78185927-78185927
GRCh38: 17:80212128-80212128
4 NMNAT1 NM_022787.4(NMNAT1):c.769G>A (p.Glu257Lys) SNV Likely pathogenic 37134 rs150726175 GRCh37: 1:10042688-10042688
GRCh38: 1:9982630-9982630
5 RASL12 , SLC51B NM_178859.4(SLC51B):c.84del (p.Arg29fs) Deletion Likely pathogenic 804474 rs1595900104 GRCh37: 15:65342421-65342421
GRCh38: 15:65050083-65050083
6 UNC45A NM_018671.5(UNC45A):c.710T>C (p.Leu237Pro) SNV Uncertain significance 978046 GRCh37: 15:91485689-91485689
GRCh38: 15:90942459-90942459
7 UNC45A NM_018671.5(UNC45A):c.1339_1340delinsCT (p.Ala447Leu) Indel Uncertain significance 978047 GRCh37: 15:91489983-91489984
GRCh38: 15:90946753-90946754
8 OCA2 NM_000275.3(OCA2):c.2020C>G (p.Leu674Val) SNV Uncertain significance 194918 rs371412500 GRCh37: 15:28171332-28171332
GRCh38: 15:27926186-27926186

Expression for Diarrhea

Search GEO for disease gene expression data for Diarrhea.

Pathways for Diarrhea

Pathways related to Diarrhea according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.56 WNT2B NEUROG3 EPCAM
2 11.09 SLC9A3 SLC51B CYP3A4
3 10.39 SLC51B CYP3A4
4 9.58 SI MGAM

GO Terms for Diarrhea

Cellular components related to Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 brush border GO:0005903 9.13 SLC9A3 SI MME
2 apical plasma membrane GO:0016324 9.02 SLC9A3 SLC26A3 SI MGAM EPCAM

Biological processes related to Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 polysaccharide digestion GO:0044245 8.62 SI MGAM

Molecular functions related to Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 alpha-1,4-glucosidase activity GO:0004558 8.62 SI MGAM

Sources for Diarrhea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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