MCID: DRR001
MIFTS: 55

Diarrhea

Categories: Gastrointestinal diseases, Genetic diseases, Oral diseases, Rare diseases

Aliases & Classifications for Diarrhea

MalaCards integrated aliases for Diarrhea:

Name: Diarrhea 12 29 6 43 44 15 40
Diarrhoea 12 15
Diarrhea of Presumed Infectious Origin 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13250
ICD9CM 35 009.2
MeSH 44 D003967
SNOMED-CT 68 19213003
UMLS 72 C0013369

Summaries for Diarrhea

MedlinePlus : 43 What is diarrhea? Diarrhea is loose, watery stools (bowel movements). You have diarrhea if you have loose stools three or more times in one day. Acute diarrhea is diarrhea that lasts a short time. It is a common problem. It usually lasts about one or two days, but it may last longer. Then it goes away on its own. Diarrhea lasting more than a few days may be a sign of a more serious problem. Chronic diarrhea -- diarrhea that lasts at least four weeks -- can be a symptom of a chronic disease. Chronic diarrhea symptoms may be continual, or they may come and go. What causes diarrhea? The most common causes of diarrhea include Bacteria from contaminated food or water Viruses such as the flu, norovirus, or rotavirus . Rotavirus is the most common cause of acute diarrhea in children. Parasites, which are tiny organisms found in contaminated food or water Medicines such as antibiotics, cancer drugs, and antacids that contain magnesium Food intolerances and sensitivities, which are problems digesting certain ingredients or foods. An example is lactose intolerance. Diseases that affect the stomach, small intestine, or colon, such as Crohn's disease Problems with how the colon functions, such as irritable bowel syndrome Some people also get diarrhea after stomach surgery, because sometimes the surgeries can cause food to move through your digestive system more quickly. Sometimes no cause can be found. If your diarrhea goes away within a few days, finding the cause is usually not necessary. Who is at risk for diarrhea? People of all ages can get diarrhea. On average, adults In the United States have acute diarrhea once a year. Young children have it an average of twice a year. People who visit developing countries are at risk for traveler's diarrhea. It is caused by consuming contaminated food or water. What other symptoms might I have with diarrhea? Other possible symptoms of diarrhea include Cramps or pain in the abdomen An urgent need to use the bathroom Loss of bowel control If a virus or bacteria is the cause of your diarrhea, you may also have a fever, chills, and bloody stools. Diarrhea can cause dehydration, which means that your body does not have enough fluid to work properly. Dehydration can be serious, especially for children, older adults, and people with weakened immune systems. When should I see a doctor for diarrhea? Although it is usually not harmful, diarrhea can become dangerous or signal a more serious problem. Contact your health care provider if you have Signs of dehydration Diarrhea for more than 2 days, if you are an adult. For children, contact the provider if it lasts more than 24 hours. Severe pain in your abdomen or rectum (for adults) A fever of 102 degrees or higher Stools containing blood or pus Stools that are black and tarry If children have diarrhea, parents or caregivers should not hesitate to call a health care provider. Diarrhea can be especially dangerous in newborns and infants. How is the cause of diarrhea diagnosed? To find the cause of diarrhea, your health care provider may Do a physical exam Ask about any medicines you are taking Test your stool or blood to look for bacteria, parasites, or other signs of disease or infection Ask you to stop eating certain foods to see whether your diarrhea goes away If you have chronic diarrhea, your health care provider may perform other tests to look for signs of disease. What are the treatments for diarrhea? Diarrhea is treated by replacing lost fluids and electrolytes to prevent dehydration. Depending on the cause of the problem, you may need medicines to stop the diarrhea or treat an infection. Adults with diarrhea should drink water, fruit juices, sports drinks, sodas without caffeine, and salty broths. As your symptoms improve, you can eat soft, bland food. Children with diarrhea should be given oral rehydration solutions to replace lost fluids and electrolytes. Can diarrhea be prevented? Two types of diarrhea can be prevented - rotavirus diarrhea and traveler's diarrhea. There are vaccines for rotavirus. They are given to babies in two or three doses. You can help prevent traveler's diarrhea by being careful about what you eat and drink when you are in developing countries: Use only bottled or purified water for drinking, making ice cubes, and brushing your teeth If you do use tap water, boil it or use iodine tablets Make sure that the cooked food you eat is fully cooked and served hot Avoid unwashed or unpeeled raw fruits and vegetables NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Diarrhea, also known as diarrhoea, is related to diarrhea 8, secretory sodium, congenital and diarrhea 1, secretory chloride, congenital. An important gene associated with Diarrhea is WNT2B (Wnt Family Member 2B), and among its related pathways/superpathways is Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Pinaverium and Carboprost tromethamine have been mentioned in the context of this disorder. Affiliated tissues include colon, testes and breast, and related phenotypes are digestive/alimentary and homeostasis/metabolism

Disease Ontology : 12 A gastrointestinal system disease described as the condition of having frequent loose or liquid bowel movements. Acute diarrhea is a common cause of death in developing countries and the second most common cause of infant deaths worldwide. The loss of fluids through diarrhea can cause severe dehydration which is one cause of death in diarrhea sufferers. Along with water, sufferers also lose dangerous amounts of important salts, electrolytes, and other nutrients. There are at least four types of diarrhea: secretory diarrhea, osmotic diarrhea, motility-related diarrhea, and inflammatory diarrhea.

Wikipedia : 75 Diarrhea, also spelled diarrhoea, is the condition of having at least three loose, liquid, or watery... more...

Related Diseases for Diarrhea

Diseases in the Diarrhea family:

Diarrhea 6 Diarrhea 9
Chronic Diarrhea Due to Guanylate Cyclase 2c Overactivity Inflammatory Diarrhea
Acute Diarrhea Congenital Diarrhea

Diseases related to Diarrhea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1370)
# Related Disease Score Top Affiliating Genes
1 diarrhea 8, secretory sodium, congenital 35.0 SPINT2 SLC9A3
2 diarrhea 1, secretory chloride, congenital 35.0 SLC9A3 SLC26A3
3 diarrhea 5, with tufting enteropathy, congenital 34.9 SPINT2 NEUROG3 MYO5B EPCAM
4 diarrhea 2, with microvillus atrophy 34.6 TTC37 SLC9A3 SLC26A3 SKIV2L MYO5B
5 trichohepatoenteric syndrome 1 34.5 TTC37 SKIV2L
6 secretory diarrhea 34.0 SST SPINT2 SLC9A3 SLC26A3 MYO5B GUCY2C
7 congenital diarrhea 33.9 SPINT2 SLC9A3 SKIV2L NEUROG3 MYO5B EPCAM
8 cryptosporidiosis 33.0 SST CD40LG
9 pancreatic cholera 32.7 SST CCK
10 pancreatitis 32.4 TMPRSS15 SST CCK
11 steatorrhea 31.4 TMPRSS15 SST CCK
12 gastrointestinal system disease 31.1 SST FOXP3 CCK
13 paralytic ileus 30.8 SLC26A3 CCK
14 acute pancreatitis 30.7 TMPRSS15 SST CCK
15 duodenal gastrinoma 30.4 SST CCK
16 postcholecystectomy syndrome 30.2 SST CCK
17 spermatocele 30.2 SLC26A3 MME
18 diarrhea 3, secretory sodium, congenital, with or without other congenital anomalies 12.6
19 diarrhea 4, malabsorptive, congenital 12.6
20 congenital chloride diarrhea 12.6
21 acute diarrhea 12.6
22 diarrhea 6 12.6
23 diarrhea 9 12.5
24 chronic diarrhea due to guanylate cyclase 2c overactivity 12.5
25 osmotic diarrhea 12.5
26 inflammatory diarrhea 12.5
27 diarrhea 10, protein-losing enteropathy type 12.4
28 congenital diarrhea 7 with exudative enteropathy 12.4
29 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 12.3
30 diarrhea 7, protein-losing enteropathy type 12.3
31 functional diarrhea 12.3
32 motility-related diarrhea 12.3
33 diarrhea, chronic, with villous atrophy 12.3
34 secretory diarrhea, myopathy, and deafness 12.3
35 diarrhea, glucose-stimulated secretory, with common variable immunodeficiency 12.2
36 dysentery 12.1
37 intractable diarrhea-choanal atresia-eye anomalies syndrome 12.1
38 genetic intractable diarrhea of infancy 12.1
39 chronic diarrhea due to glucoamylase deficiency 12.1
40 hemolytic uremic syndrome, atypical 1 12.0
41 satoyoshi syndrome 11.9
42 wdha syndrome 11.9
43 vipoma 11.9
44 cholera 11.7
45 gastroenteritis 11.7
46 irritable bowel syndrome 11.7
47 shigellosis 11.6
48 salmonellosis 11.5
49 lactose intolerance 11.5
50 celiac disease 1 11.5

Graphical network of the top 20 diseases related to Diarrhea:



Diseases related to Diarrhea

Symptoms & Phenotypes for Diarrhea

MGI Mouse Phenotypes related to Diarrhea:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.91 DGAT1 EPCAM FOXP3 GUCY2C MYO5B NEUROG3
2 homeostasis/metabolism MP:0005376 9.77 CCK CD40LG DGAT1 EPCAM FOXP3 GUCY2C
3 endocrine/exocrine gland MP:0005379 9.76 CCK CD40LG DGAT1 EPCAM FOXP3 NEUROG3
4 no phenotypic analysis MP:0003012 9.17 ANTXR2 CCK EPCAM FOXP3 NEUROG3 SST

Drugs & Therapeutics for Diarrhea

Drugs for Diarrhea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 991)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pinaverium Approved Phase 4 59995-65-2
2
Carboprost tromethamine Approved Phase 4 58551-69-2 35023177 5284525
3
Scopolamine Approved, Investigational Phase 4 6533-68-2, 51-34-3 5184
4
Mecasermin Approved, Investigational Phase 4 68562-41-4
5
Iron isomaltoside 1000 Approved, Investigational Phase 4 1370654-58-2
6
Cobicistat Approved Phase 4 1004316-88-4
7
Rilpivirine Approved Phase 4 500287-72-9
8
Ondansetron Approved Phase 4 99614-02-5 4595
9
chenodeoxycholic acid Approved Phase 4 474-25-9 10133
10
Zinc sulfate Approved, Investigational Phase 4 7733-02-0
11
Metformin Approved Phase 4 657-24-9 4091 14219
12
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
13
Artesunate Approved, Investigational Phase 4 88495-63-0 5464098 6917864
14
Formaldehyde Approved, Vet_approved Phase 4 50-00-0 712
15
Lactulose Approved Phase 4 4618-18-2 11333
16
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
17
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
18
Calcium carbonate Approved, Investigational Phase 4 471-34-1
19
Cefpirome Approved Phase 4 84957-29-9 5479539
20
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
21
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
22
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
23
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
24
Polyestradiol phosphate Approved Phase 4 28014-46-2
25
Ofloxacin Approved Phase 4 82419-36-1 4583
26
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
27
Nicotinamide Approved, Investigational Phase 4 98-92-0 936
28
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
29 Strawberry Approved Phase 4
30
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
31
Sulfamethoxazole Approved Phase 4 723-46-6 5329
32
Lumefantrine Approved Phase 4 82186-77-4 6437380
33
Artemether Approved Phase 4 71963-77-4 68911 119380
34
Dimenhydrinate Approved Phase 4 523-87-5 441281
35
Metoclopramide Approved, Investigational Phase 4 364-62-5 4168
36
Linaclotide Approved Phase 4 851199-59-2 65351
37
Sucralfate Approved Phase 4 54182-58-0
38
Dronabinol Approved, Illicit Phase 4 1972-08-3 16078
39
Aminophylline Approved Phase 4 317-34-0 9433
40
Regadenoson Approved, Investigational Phase 4 313348-27-5 219024
41
Adenosine Approved, Investigational Phase 4 58-61-7 60961
42
Insulin Aspart Approved Phase 4 116094-23-6 16132418
43
Granisetron Approved, Investigational Phase 4 109889-09-0 3510
44
Chlorpheniramine Approved Phase 4 132-22-9, 113-92-8 2725
45
Ranitidine Approved Phase 4 66357-35-5, 66357-59-3 3001055
46
Gliclazide Approved Phase 4 21187-98-4 3475
47
Methylene blue Approved, Investigational Phase 4 61-73-4
48
Nystatin Approved, Vet_approved Phase 4 1400-61-9 11953884
49
Mebendazole Approved, Vet_approved Phase 4 31431-39-7 4030
50
Sorbitol Approved Phase 4 50-70-4 5780

Interventional clinical trials:

(show top 50) (show all 2380)
# Name Status NCT ID Phase Drugs
1 Comparing a Probiotic and Non-probiotic Intervention in Their Ability to Improve Bowel Habits of Residents in Nursing Homes Unknown status NCT02949882 Phase 4
2 The Impact of Lactobacillus Preparation on the Incidence of Diarrhea in Intensive Care Unit-admitted Patients : Randomized Controlled Trial Unknown status NCT01792739 Phase 4 Lactobacillus casei variety rhamnosus granules;Placebo
3 Bacillus Particles Prevent More Children's Antibiotic-associated Diarrhea (AAD), Randomized, Double-blind, Controlled Clinical Trial Unknown status NCT02993419 Phase 4 Bacillus licheniformis Intervention
4 Prophylaxis of Gastrointestinal Infections in Newborn and Infants With a Suspension Containing the Probiotic Escherichia Coli Strain Nissle Unknown status NCT01469273 Phase 4 Mutaflor® Suspension
5 Effect of a Mixture of Probiotics, Lactibiane Tolérance® on Intestinal Permeability in Individuals Suffering From Irritable Bowel Syndrome With Diarrheal Predominance Unknown status NCT02728063 Phase 4
6 Role Of Saccharomyces Boulardii In Diarrhea Dominant Irritable Bowel Syndrome Unknown status NCT00543478 Phase 4 Saccharomyces boulardii;Methyl cellulose powder (low viscosity)
7 The Efficacy of Hydrolyzed Guar Gum ( PHGG) in the Treatment of Patients With Irritable Bowel Syndrome- a Double Blind, Placebo - Controlled, Randomized Study Unknown status NCT01779765 Phase 4
8 Polyethylene Glycol for Childhood Constipation Unknown status NCT01875744 Phase 4 Polyethylene glycol 4000
9 The Effect of Probiotics on the Rate of Recovery of Inflammatory Bowel Disease Exacerbation (Crohn's Disease) and Markers of Inflammation Unknown status NCT01765998 Phase 4 Probiotic;Placebo
10 Phase 4 Study of Effects of Dexmedetomidine on Prevention of Side Effects of Hemabate in Cesarean Section Patients Unknown status NCT02220361 Phase 4 placebo;low dose dexmedetomidine;high dose dexmedetomidine
11 The Role of Short-course Ceftriaxone Therapy in the Treatment of Severe Nontyphoidal Salmonella Enterocolitis Unknown status NCT01278017 Phase 4 ceftriaxone
12 Effect of Ramosetron on Postoperative Restoration of Bowel Motility After Gynecological Laparoscopic Surgery Unknown status NCT02849483 Phase 4 Ramosetron;Normal saline
13 Adherence to Therapy in COPD Patients Under Dose Escalation of Roflumilast Unknown status NCT02018432 Phase 4 Roflumilast escalation dosage;Roflumilast conventional dosage
14 Effect of Ramosetron on Bowel Motility and PONV After Laparoscopic Stomach and Colorectal Resection Unknown status NCT01427127 Phase 4 Ramosetron
15 Irinotecan Plus Thalidomide in Second Line Advanced Gastric Cancer : A Multicenter, Randomized, Controlled and Prospective Trial Unknown status NCT02401971 Phase 4 Thalidomide;CPT-11
16 Randomized, Double Blind, Placebo Control Trial to Evaluate the Efficacy of Wu-Chu-Yu Tang on Gastroesophageal Reflux Disease (GERD) Unknown status NCT01822106 Phase 4
17 Application of Pinaverium Bromide in the Treatment of Patients With Post-cholecystectomy Sphincter of Oddi Dysfunction (SOD): A Randomized, Controlled and Multicenter Clinical Study Unknown status NCT02833103 Phase 4 Danshu Capsules;Pinaverium Bromide
18 The Clinical Use of Probiotics in the Uremia Patients Under Chronic Peritoneal Dialysis Unknown status NCT01076426 Phase 4 Pro-biotics
19 Assessment of Analgesic Efficacy and Safety of Intravenous Hyoscine-N-Butylbromide in Patients With Abdominal Colic Associated With Acute Gastroenteritis; a Randomized, Double-blind, Placebo Controlled Study Unknown status NCT02508142 Phase 4 Hyoscine-N-Butylbromide
20 Bacteria and Cytokines as Factors Modulating Visceral Afferent Processing in Irritable Bowel Syndrome: Manipulation of Intestinal Bacteria and Mucosal Cytokines by Probiotic Therapy and the Effect on Visceral Hypersensitivity Unknown status NCT00418340 Phase 4 probiotic (bacterial/dietary supplement)
21 Adjunct Methadone to Decrease the Duration of Mechanical Ventilation in the Medical Intensive Care Unit Unknown status NCT02025855 Phase 4 Methadone;Placebo
22 Effects of N-Acetyl-Cysteine on Oxidative Stress Biomarkers in Bipolar Patients With and Without Tobacco Use Disorder Unknown status NCT02252341 Phase 4
23 The Hypotensive Effect of Simvastatin in Hypertensive Patients: a Placebo-controlled Randomized Clinical Trial With 24-h Ambulatory Blood Pressure Monitoring Unknown status NCT02072382 Phase 4 Metformin;Placebo
24 Evaluation Whether Higher Retention Rate is in Those of Combined Methadone With N-Acetyl-Cysteine Compared to Those With Methadone Alone During a Six-month Study Unknown status NCT01047956 Phase 4 Methadone; NAC;Methadone
25 Metabolic, Cardiovascular and Body Composition Effects of Sandostatin LAR® Therapy of Acromegaly, Effect of Reduction of Serum Insulin-like Growth Factor 1 (IGF-1) Levels Into a New Normative Range Unknown status NCT01424241 Phase 4 Sandostatin LAR
26 An Open Pilot Study to Evaluate the Efficacy and Safety, Tolerability of Raltegravir(RAL)in Treatment-experienced HIV-1 Infected Adult Chinese Patients Unknown status NCT01201239 Phase 4 raltegravir
27 An Pilot Study to Assess the Efficacy of Intravenous Iron Isomaltoside 1000 (Monofer®) in the Management of Anaemia Associated With the Palliative Management of Oesophagogastric Adenocarcinoma Unknown status NCT01927328 Phase 4 Iron isomaltoside 1000
28 Evaluation of the Efficacy in Decreasing Iron Absorption in Patients With Congenital Dyserythropoietic Anemia Type I by Treatment With LOSEC Unknown status NCT01795794 Phase 4 omeprazole
29 Treatment With Acetyl-Choline Esterase Inhibitors in Children With Autism Unknown status NCT01098383 Phase 4 Acetyl-Choline Esterase Inhibitors and Choline supplements;Indistinguishable placebo tablets, matching both donepezil and choline
30 COLITIS: Clostridial Infection and Oral Lavage -Improving Treatment Before Illness Becomes Severe Unknown status NCT01630096 Phase 4 Nu-Lytely
31 Adverse Effects of Glucocorticoid Therapy on Bone in Childhood Crohn's Disease Unknown status NCT00609752 Phase 4 prednisolone
32 Randomized Cross-Over Trial of Captafer® vs. Oral Iron Sulfate in the Treatment of Iron Deficiency Anemia in Patients With Inflammatory Bowel Disease Unknown status NCT02774057 Phase 4 Captafer®;Iron Sulfate
33 Metformin for Weight Control in Adolescents Taking Atypical Antipsychotics- Double Blind Placebo Controlled Study Unknown status NCT00845936 Phase 4 Metformin
34 A Phase IV 48 Week, Open Label, Pilot Study of Darunavir Boosted by Cobicistat in Combination With Rilpivirine to Treat HIV+ Naïve Subjects (PREZENT) Unknown status NCT02404233 Phase 4 darunavir/cobicistat;rilpivirine
35 Multicenter Study Evaluating the Efficacy of Dicopeg Junior in Comparison With Lactulose for the Treatment of Functional Constipation in Children Aged 6 Months to 6 Years. A Prospective, Randomized Study. Unknown status NCT03177434 Phase 4 polyethylene glycols (PEG) 3350;Lactulose Oral Product
36 Prospective, Interventional, Single Arm Study in Outpatients Undergoing Sigmoidoscopy for Evaluation of Efficacy and Safety of Kleen Enema 120ml (Phosphate Enema) Unknown status NCT02386904 Phase 4 Phosphate Enema (Kleen® Enema)
37 ASSESSMENT OF GH-IGF1 AXIS AND TO STUDY RESPONSE TO GH THERAPY IN CHILDREN WITH CML IN REMISSION HAVING GH DEFICIENCY Unknown status NCT01901666 Phase 4 Growth Hormone
38 Efficacy of Diosmectite (Smecta®) in the Treatment of Acute Diarrhoea in Adults. A Multicentre, Randomised, Double Blind, Placebo Controlled, Parallel Groups Study. Completed NCT00276328 Phase 4 Diosmectite (Smecta®)
39 Efficacy of Diosmectite (Smecta®) in the Symptomatic Treatment of Acute Diarrhoea in Adults. A Multicentre, Randomized, Double Blind Placebo Controlled, Parallel, Groups Study Completed NCT02704091 Phase 4 Smecta;Smecta placebo
40 Efficacy and Mode of Action of Mesalazine in the Treatment of Diarrhoea-predominant Irritable Bowel Syndrome (IBS-D). Completed NCT01316718 Phase 4 Mesalazine;Placebo
41 Ondansetron for the Treatment of IBS With Diarrhoea (IBS-D): Identifying the "Responder" Completed NCT00745004 Phase 4 Ondansetron;Placebo
42 Validation of Stimulated ∆FGF19 for Diagnosing Bile Acid Diarrhoea Completed NCT03059537 Phase 4 Oral chenodeoxycholic acid stimulation
43 A Randomised Placebo Controlled Trial of "Follow on" Rifaximin for the Prevention of Relapse of Clostridium Associated Diarrhoea Completed NCT01670149 Phase 4 Rifaximin;Placebo
44 Introduction of New Hypo-Osmolar ORS (Recommended by WHO) for Routine Use in the Management of Diarrhoeal Diseases – A Phase IV Surveillance Study Completed NCT00490932 Phase 4 Hypo-osmolar ORS
45 A Community Based Intervention and Evaluation of the Impact of Social Marketing of a Diarrhea Management Pack(Comprising of Low Osmolality ORS, Zinc Tablets, Water Purification Tablets and Pictorial Chart) on Childhood Diarrhea. Completed NCT00942812 Phase 4
46 Introduction of New Hypo-osmolar ORS Into Routine Use in the Management of Diarrhoeal Disease: a Phase IV Clinical Surveillance. Completed NCT00244777 Phase 4 Hypo-osmolar ORS
47 Immune Response After Inactivated Oral Cholera Vaccine (Dukoral) in Renal Transplant Recipients Completed NCT01109914 Phase 4
48 STOP Trial - Sandostatin LAR Depot Trial for the Optimum Prevention of Chemotherapy Induced Diarrhea Completed NCT00050635 Phase 4 Sandostatin LAR Depot
49 Post-marketing Clinical Study of Ramosetron Hydrochloride (Irribow Tablets) - Double-blind, Parallel-group Comparative Study in Patients (Male) With Diarrhea-predominant Irritable Bowel Syndrome Completed NCT01225237 Phase 4 Ramosetron;Placebo
50 Efficacy of Glutamine in the Prevention of Acute Radiation Enteritis Among Patients Treated With Radiation of Abdomen and Pelvis. Completed NCT00828399 Phase 4

Search NIH Clinical Center for Diarrhea

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Bismuth subsalicylate
Difenoxin
Diphenoxylate
Loperamide
Pancrelipase
Sodium phosphate, monobasic

Cochrane evidence based reviews: diarrhea

Genetic Tests for Diarrhea

Genetic tests related to Diarrhea:

# Genetic test Affiliating Genes
1 Diarrhea 29

Anatomical Context for Diarrhea

MalaCards organs/tissues related to Diarrhea:

41
Colon, Testes, Breast, Small Intestine, Lung, Liver, Kidney

Publications for Diarrhea

Articles related to Diarrhea:

(show top 50) (show all 55786)
# Title Authors PMID Year
1
Impact of a school-based water, sanitation, and hygiene intervention on school absence, diarrhea, respiratory infection, and soil-transmitted helminths: results from the WASH HELPS cluster-randomized trial. 38 17
31360445 2019
2
Clinical efficacy of oral immunoglobulin Y in infant rotavirus enteritis: Systematic review and meta-analysis. 38 17
31277110 2019
3
Clinical evaluation of the use of an mhealth intervention on quality of care provided by Community Health Workers in southwest Niger. 17
31263555 2019
4
Lessons from the integrated community case management (iCCM) Rapid Access Expansion Program. 38
31360441 2019
5
Pegbelfermin (BMS-986036), a PEGylated fibroblast growth factor 21 analogue, in patients with non-alcoholic steatohepatitis: a randomised, double-blind, placebo-controlled, phase 2a trial. 38
30554783 2019
6
Identification and prevalence of in vivo-induced genes in enterohaemorrhagic Escherichia coli. 38
30806162 2019
7
Effects of Phyllanthus amarus PHYLLPROTM leaves on hangover symptoms: a randomized, double-blind, placebo-controlled crossover study. 38
30922154 2019
8
Modelling the dynamics of direct and pathogens-induced dysentery diarrhoea epidemic with controls. 38
30843764 2019
9
Chitosan nano-structure loaded with recombinant E. coli O157:H7 antigens as a vaccine candidate can effectively increase immunization capacity. 38
31240960 2019
10
Metabolite profiling and identification of enzymes responsible for the metabolism of mitragynine, the major alkaloid of Mitragyna speciosa (kratom). 38
30547698 2019
11
Diarrhea and patient outcomes in the intensive care unit: Systematic review and meta-analysis. 38
31238230 2019
12
Establishment and application of a multiplex RT-PCR to differentiate wild-type and vaccine strains of porcine epidemic diarrhea virus. 38
31288038 2019
13
Prevalence and genetic diversity of human sapovirus associated with sporadic acute gastroenteritis in South China from 2013 to 2017. 38
31180139 2019
14
Phylogenetic and immunoinformatic analysis of VP4, VP7, and NSP4 genes of rotavirus strains circulating in children with acute gastroenteritis in Indonesia. 38
31243786 2019
15
Molecular epidemiology of group A rotavirus in outpatient diarrhea infants and children in Chongqing, China, 2011-2015. 38
31241179 2019
16
Evaluation of currently available bovine viral diarrhoea virus (BVDV) and HoBi-like pestivirus (HoBiPeV) specific diagnostic tests in detection of highly divergent HoBiPeVs in cattle. 38
31351170 2019
17
Effects of three husbandry systems on health, welfare and productivity of organic pigs. 38
30761969 2019
18
Infection, colonization and shedding of Campylobacter and Salmonella in animals and their contribution to human disease: A review. 38
31179637 2019
19
Adverse outcomes in obstetric-atypical haemolytic uraemic syndrome: a case series analysis. 38
29606012 2019
20
Management of Diarrhea in Patients With Carcinoid Syndrome. 38
31425482 2019
21
Development of a Model of Porcine Epidemic Diarrhea in Microminipigs. 38
30991905 2019
22
Prevalence of, and predictors of, bile acid diarrhea in outpatients with chronic diarrhea: A follow-up study. 38
31225936 2019
23
Genetic analysis of bovine viral diarrhea virus in pre-weaned native Korean calves. 38
30955148 2019
24
Anti-diarrhea effects and identification of Musca domestica larvae low molecular weight peptides (LMWP). 38
31146171 2019
25
Faecal microbiota transplantation for diarrhoea-predominant irritable bowel syndrome: a double-blind, randomised, placebo-controlled trial. 38
31326345 2019
26
Recommendations for the testing and control of bovine viral diarrhoea in New Zealand pastoral cattle production systems. 38
31104579 2019
27
A novel reassortant mammalian orthoreovirus with a divergent S1 genome segment identified in a traveler with diarrhea. 38
31176029 2019
28
Polymorphisms in the promotor region of the CRBN gene as a predictive factor for peripheral neuropathy in the course of thalidomide-based chemotherapy in multiple myeloma patients. 38
31115923 2019
29
Vincristine, irinotecan, and temozolomide treatment for refractory/relapsed pediatric solid tumors: A single center experience. 38
30080131 2019
30
A fatal case of bowel obstruction caused by non-steroidal anti-inflammatory drug enteropathy. 38
30632013 2019
31
Bacillus Clausii Septicemia in a Pediatric Patient After Treatment With Probiotics. 38
31033906 2019
32
Ileal Neuroendocrine Tumor With Bilateral Breast and Ovarian Metastases: Findings on 68Ga-DOTANOC PET/CT Scan. 38
31274557 2019
33
Maintenance of Intestinal Epithelial Homeostasis by Zinc Transporters. 38
30830525 2019
34
Nivolumab in patients with unresectable locally advanced or metastatic urothelial carcinoma: CheckMate 275 2-year global and Japanese patient population analyses. 38
31218529 2019
35
Safety and activity of ivosidenib in patients with IDH1-mutant advanced cholangiocarcinoma: a phase 1 study. 38
31300360 2019
36
Microvillous Inclusion Disease as a Cause of Protracted Diarrhea. 38
31049800 2019
37
Detection and spike gene characterization in porcine deltacoronavirus in China during 2016-2018. 38
31026605 2019
38
Correlates of Gut Function in Children Hospitalized for Severe Acute Malnutrition, a Cross-sectional Study in Uganda. 38
31169661 2019
39
Retrospective analysis of Cryptosporidium species in Western Australian human populations (2015-2018), and emergence of the C. hominis IfA12G1R5 subtype. 38
31146044 2019
40
Prophylactic use of probiotics for gastrointestinal disorders in children. 38
31279590 2019
41
Safety and efficacy of intravenous bimagrumab in inclusion body myositis (RESILIENT): a randomised, double-blind, placebo-controlled phase 2b trial. 38
31397289 2019
42
A Meta-analysis Assessing Diarrhea and Pneumonia in HIV-Exposed Uninfected Compared With HIV-Unexposed Uninfected Infants and Children. 38
31408450 2019
43
Effect of in-line drinking water chlorination at the point of collection on child diarrhoea in urban Bangladesh: a double-blind, cluster-randomised controlled trial. 38
31402005 2019
44
Abnormalities of mucosal serotonin metabolism and 5-HT3 receptor subunit 3C polymorphism in irritable bowel syndrome with diarrhoea predict responsiveness to ondansetron. 38
31342534 2019
45
Patients' preferences for postmenopausal hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer treatments in Japan. 38
30949915 2019
46
In vitro antimicrobial activity against equine Lawsonia intracellularis strains. 38
30629755 2019
47
Economic Evaluation of Human Rotavirus Vaccine in Thailand. 38
31197662 2019
48
Whole genome characterization of feline-like G3P[8] reassortant rotavirus A strains bearing the DS-1-like backbone genes detected in Vietnam, 2016. 38
30978460 2019
49
Health sequelae of human cryptosporidiosis-a 12-month prospective follow-up study. 38
31302785 2019
50
Prevalence of Giardia intestinalis with other co-infecting parasites in Barak Valley, Assam, India: a molecular approach. 38
31406408 2019

Variations for Diarrhea

ClinVar genetic disease variations for Diarrhea:

6
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 WNT2B NM_004185.4(WNT2B): c.148C> T (p.Arg50Ter) single nucleotide variant Pathogenic rs370244148 1:113057518-113057518 1:112514896-112514896

Expression for Diarrhea

Search GEO for disease gene expression data for Diarrhea.

Pathways for Diarrhea

Pathways related to Diarrhea according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.92 WNT2B NEUROG3 EPCAM

GO Terms for Diarrhea

Cellular components related to Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 9.46 SLC9A3 SLC26A3 SI EPCAM
2 Ski complex GO:0055087 8.96 TTC37 SKIV2L
3 brush border GO:0005903 8.92 TMPRSS15 SLC9A3 SI MME
4 integral component of membrane GO:0016021 10.03 TMPRSS15 SPINT2 SLC9A3 SLC26A3 SI MME

Biological processes related to Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA catabolic process GO:0006401 9.16 TTC37 SKIV2L
2 positive regulation of interleukin-4 production GO:0032753 8.96 FOXP3 CD40LG
3 digestion GO:0007586 8.8 SST GUCY2C CCK

Sources for Diarrhea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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