MCID: DRR001
MIFTS: 57

Diarrhea

Categories: Gastrointestinal diseases, Genetic diseases, Oral diseases, Rare diseases

Aliases & Classifications for Diarrhea

MalaCards integrated aliases for Diarrhea:

Name: Diarrhea 12 29 6 42 43 15 39
Diarrhoea 12 15
Diarrhea of Presumed Infectious Origin 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13250
ICD9CM 34 009.2
MeSH 43 D003967
SNOMED-CT 67 19213003
UMLS 71 C0013369

Summaries for Diarrhea

MedlinePlus : 42 What is diarrhea? Diarrhea is loose, watery stools (bowel movements). You have diarrhea if you have loose stools three or more times in one day. Acute diarrhea is diarrhea that lasts a short time. It is a common problem. It usually lasts about one or two days, but it may last longer. Then it goes away on its own. Diarrhea lasting more than a few days may be a sign of a more serious problem. Chronic diarrhea -- diarrhea that lasts at least four weeks -- can be a symptom of a chronic disease. Chronic diarrhea symptoms may be continual, or they may come and go. What causes diarrhea? The most common causes of diarrhea include Bacteria from contaminated food or water Viruses such as the flu, norovirus, or rotavirus . Rotavirus is the most common cause of acute diarrhea in children. Parasites, which are tiny organisms found in contaminated food or water Medicines such as antibiotics, cancer drugs, and antacids that contain magnesium Food intolerances and sensitivities, which are problems digesting certain ingredients or foods. An example is lactose intolerance. Diseases that affect the stomach, small intestine, or colon, such as Crohn's disease Problems with how the colon functions, such as irritable bowel syndrome Some people also get diarrhea after stomach surgery, because sometimes the surgeries can cause food to move through your digestive system more quickly. Sometimes no cause can be found. If your diarrhea goes away within a few days, finding the cause is usually not necessary. Who is at risk for diarrhea? People of all ages can get diarrhea. On average, adults In the United States have acute diarrhea once a year. Young children have it an average of twice a year. People who visit developing countries are at risk for traveler's diarrhea. It is caused by consuming contaminated food or water. What other symptoms might I have with diarrhea? Other possible symptoms of diarrhea include Cramps or pain in the abdomen An urgent need to use the bathroom Loss of bowel control If a virus or bacteria is the cause of your diarrhea, you may also have a fever, chills, and bloody stools. Diarrhea can cause dehydration, which means that your body does not have enough fluid to work properly. Dehydration can be serious, especially for children, older adults, and people with weakened immune systems. When should I see a doctor for diarrhea? Although it is usually not harmful, diarrhea can become dangerous or signal a more serious problem. Contact your health care provider if you have Signs of dehydration Diarrhea for more than 2 days, if you are an adult. For children, contact the provider if it lasts more than 24 hours. Severe pain in your abdomen or rectum (for adults) A fever of 102 degrees or higher Stools containing blood or pus Stools that are black and tarry If children have diarrhea, parents or caregivers should not hesitate to call a health care provider. Diarrhea can be especially dangerous in newborns and infants. How is the cause of diarrhea diagnosed? To find the cause of diarrhea, your health care provider may Do a physical exam Ask about any medicines you are taking Test your stool or blood to look for bacteria, parasites, or other signs of disease or infection Ask you to stop eating certain foods to see whether your diarrhea goes away If you have chronic diarrhea, your health care provider may perform other tests to look for signs of disease. What are the treatments for diarrhea? Diarrhea is treated by replacing lost fluids and electrolytes to prevent dehydration. Depending on the cause of the problem, you may need medicines to stop the diarrhea or treat an infection. Adults with diarrhea should drink water, fruit juices, sports drinks, sodas without caffeine, and salty broths. As your symptoms improve, you can eat soft, bland food. Children with diarrhea should be given oral rehydration solutions to replace lost fluids and electrolytes. Can diarrhea be prevented? Two types of diarrhea can be prevented - rotavirus diarrhea and traveler's diarrhea. There are vaccines for rotavirus. They are given to babies in two or three doses. You can help prevent traveler's diarrhea by being careful about what you eat and drink when you are in developing countries: Use only bottled or purified water for drinking, making ice cubes, and brushing your teeth If you do use tap water, boil it or use iodine tablets Make sure that the cooked food you eat is fully cooked and served hot Avoid unwashed or unpeeled raw fruits and vegetables NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Diarrhea, also known as diarrhoea, is related to diarrhea 2, with microvillus atrophy and diarrhea 3, secretory sodium, congenital, with or without other congenital anomalies. An important gene associated with Diarrhea is WNT2B (Wnt Family Member 2B), and among its related pathways/superpathways are Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics and Bile secretion. The drugs Pinaverium and Carboprost tromethamine have been mentioned in the context of this disorder. Affiliated tissues include colon, testes and breast, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

Disease Ontology : 12 A gastrointestinal system disease described as the condition of having frequent loose or liquid bowel movements. Acute diarrhea is a common cause of death in developing countries and the second most common cause of infant deaths worldwide. The loss of fluids through diarrhea can cause severe dehydration which is one cause of death in diarrhea sufferers. Along with water, sufferers also lose dangerous amounts of important salts, electrolytes, and other nutrients. There are at least four types of diarrhea: secretory diarrhea, osmotic diarrhea, motility-related diarrhea, and inflammatory diarrhea.

Wikipedia : 74 Diarrhea, also spelled diarrhoea, is the condition of having at least three loose, liquid, or watery... more...

Related Diseases for Diarrhea

Diseases in the Diarrhea family:

Diarrhea 6 Diarrhea 9
Chronic Diarrhea Due to Guanylate Cyclase 2c Overactivity Inflammatory Diarrhea
Acute Diarrhea Congenital Diarrhea

Diseases related to Diarrhea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1376)
# Related Disease Score Top Affiliating Genes
1 diarrhea 2, with microvillus atrophy 35.1 TTC37 SLC9A3 SLC26A3 MYO5B
2 diarrhea 3, secretory sodium, congenital, with or without other congenital anomalies 35.1 SPINT2 SLC9A3 GUCY2C
3 diarrhea 1, secretory chloride, congenital 35.1 TTC37 SLC9A3 SLC26A3
4 diarrhea 5, with tufting enteropathy, congenital 35.0 TTC37 SPINT2 SLC26A3 NEUROG3 MYO5B EPCAM
5 diarrhea 4, malabsorptive, congenital 35.0 TTC37 NEUROG3 MYO5B
6 osmotic diarrhea 34.8 WNT2B SLC9A3 SLC26A3
7 secretory diarrhea 34.7 SST SPINT2 SLC9A3 SLC26A3 MYO5B GUCY2C
8 inflammatory diarrhea 34.6 SLC9A3 SLC26A3
9 congenital diarrhea 34.6 TTC37 SPINT2 SLC9A3 SLC26A3 NEUROG3 MYO5B
10 short bowel syndrome 33.2 SST SLC9A3 CCK
11 bile acid malabsorption, primary 33.1 TMPRSS15 SST CCK
12 opioid addiction 32.1 CCK ABCB1
13 dumping syndrome 31.4 SST SI CCK
14 ileus 31.3 SST SLC9A3 GUCY2C CCK
15 acute pancreatitis 30.8 TMPRSS15 SST CCK
16 duodenitis 30.8 CD40LG CCK
17 cholelithiasis 30.7 SST CD40LG CCK
18 gastroparesis 30.5 SST CYP3A4 CCK ABCB1
19 spermatocele 30.5 SLC9A3 SLC26A3
20 biliary dyskinesia 30.5 SST CCK
21 colon adenocarcinoma 30.4 SI EPCAM CYP3A4 ABCB1
22 cerebral lymphoma 30.4 SST CD40LG
23 postgastrectomy syndrome 30.4 SST SI
24 hair disease 30.3 CYP3A4 CD40LG ANTXR2
25 bacterial conjunctivitis 30.3 TTC37 CD40LG
26 congenital chloride diarrhea 12.6
27 acute diarrhea 12.6
28 diarrhea 6 12.6
29 diarrhea 8, secretory sodium, congenital 12.6
30 diarrhea 9 12.5
31 chronic diarrhea due to guanylate cyclase 2c overactivity 12.5
32 diarrhea 11, malabsorptive, congenital 12.5
33 diarrhea 10, protein-losing enteropathy type 12.4
34 congenital diarrhea 7 with exudative enteropathy 12.4
35 trichohepatoenteric syndrome 1 12.4
36 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 12.3
37 diarrhea 7, protein-losing enteropathy type 12.3
38 motility-related diarrhea 12.3
39 functional diarrhea 12.3
40 diarrhea, chronic, with villous atrophy 12.2
41 secretory diarrhea, myopathy, and deafness 12.2
42 diarrhea, glucose-stimulated secretory, with common variable immunodeficiency 12.2
43 dysentery 12.2
44 intractable diarrhea-choanal atresia-eye anomalies syndrome 12.1
45 genetic intractable diarrhea of infancy 12.1
46 syndromic congenital sodium diarrhea 12.1
47 chronic diarrhea due to glucoamylase deficiency 12.1
48 hemolytic uremic syndrome, atypical 1 12.0
49 satoyoshi syndrome 11.9
50 pancreatic cholera 11.9

Graphical network of the top 20 diseases related to Diarrhea:



Diseases related to Diarrhea

Symptoms & Phenotypes for Diarrhea

MGI Mouse Phenotypes related to Diarrhea:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.96 ABCB1 DGAT1 EPCAM FOXP3 GUCY2C MYO5B
2 endocrine/exocrine gland MP:0005379 9.81 ABCB1 CCK CD40LG DGAT1 EPCAM FOXP3
3 homeostasis/metabolism MP:0005376 9.8 ABCB1 CCK CD40LG DGAT1 EPCAM FOXP3
4 no phenotypic analysis MP:0003012 9.23 ABCB1 ANTXR2 CCK EPCAM FOXP3 NEUROG3

Drugs & Therapeutics for Diarrhea

Drugs for Diarrhea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 974)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pinaverium Approved Phase 4 59995-65-2
2
Carboprost tromethamine Approved Phase 4 58551-69-2 5284525 35023177
3
Scopolamine Approved, Investigational Phase 4 51-34-3, 6533-68-2 5184
4
Iron isomaltoside 1000 Approved, Investigational Phase 4 1370654-58-2
5
Mecasermin Approved, Investigational Phase 4 68562-41-4
6
Rilpivirine Approved Phase 4 500287-72-9
7
Cobicistat Approved Phase 4 1004316-88-4
8
Ondansetron Approved Phase 4 99614-02-5 4595
9
chenodeoxycholic acid Approved Phase 4 474-25-9 10133
10
Zinc sulfate Approved, Investigational Phase 4 7733-02-0
11
Metformin Approved Phase 4 657-24-9 14219 4091
12
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
13
Artesunate Approved, Investigational Phase 4 88495-63-0 6917864 5464098
14
Formaldehyde Approved, Vet_approved Phase 4 50-00-0 712
15 Strawberry Approved Phase 4
16
Lactulose Approved Phase 4 4618-18-2 11333
17
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
18
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
19
Calcium carbonate Approved, Investigational Phase 4 471-34-1
20
Cefpirome Approved Phase 4 84957-29-9 5479539
21
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
22
Moxifloxacin Approved, Investigational Phase 4 151096-09-2, 354812-41-2 152946
23
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
24
Polyestradiol phosphate Approved Phase 4 28014-46-2
25
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
26
Nicotinamide Approved, Investigational Phase 4 98-92-0 936
27
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
28
Lumefantrine Approved Phase 4 82186-77-4 6437380
29
Artemether Approved Phase 4 71963-77-4 119380 68911
30
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
31
Sulfamethoxazole Approved Phase 4 723-46-6 5329
32
Mebeverine Approved, Investigational Phase 4 3625-06-7 62887
33
Alverine Approved, Investigational Phase 4 150-59-4 3678
34
Dimenhydrinate Approved Phase 4 523-87-5 441281
35
Metoclopramide Approved, Investigational Phase 4 364-62-5 4168
36
Linaclotide Approved Phase 4 851199-59-2 65351
37
Dronabinol Approved, Illicit Phase 4 1972-08-3 16078
38
Regadenoson Approved, Investigational Phase 4 313348-27-5 219024
39
Adenosine Approved, Investigational Phase 4 58-61-7 60961
40
Aminophylline Approved Phase 4 317-34-0 9433
41
Gliclazide Approved Phase 4 21187-98-4 3475
42
Insulin aspart Approved Phase 4 116094-23-6 16132418
43
Granisetron Approved, Investigational Phase 4 109889-09-0 3510
44
Methylene blue Approved, Investigational Phase 4 61-73-4
45
Nystatin Approved, Vet_approved Phase 4 1400-61-9 11953884
46
Mebendazole Approved, Vet_approved Phase 4 31431-39-7 4030
47
Sorbitol Approved Phase 4 50-70-4 5780
48
Pyrazinamide Approved, Investigational Phase 4 98-96-4 1046
49
Tranexamic Acid Approved Phase 4 1197-18-8 5526
50
Sertraline Approved Phase 4 79617-96-2 68617

Interventional clinical trials:

(show top 50) (show all 2456)
# Name Status NCT ID Phase Drugs
1 Comparing a Probiotic and Non-probiotic Intervention in Their Ability to Improve Bowel Habits of Residents in Nursing Homes Unknown status NCT02949882 Phase 4
2 Cross-reactive Immunity Elicited by Oral and Parenteral Typhoid Vaccines Against Non-typhoid Salmonellae Unknown status NCT02121145 Phase 4
3 The Impact of Lactobacillus Preparation on the Incidence of Diarrhea in Intensive Care Unit-admitted Patients : Randomized Controlled Trial Unknown status NCT01792739 Phase 4 Lactobacillus casei variety rhamnosus granules;Placebo
4 Bacillus Particles Prevent More Children's Antibiotic-associated Diarrhea (AAD), Randomized, Double-blind, Controlled Clinical Trial Unknown status NCT02993419 Phase 4 Bacillus licheniformis Intervention
5 Prophylaxis of Gastrointestinal Infections in Newborn and Infants With a Suspension Containing the Probiotic Escherichia Coli Strain Nissle Unknown status NCT01469273 Phase 4 Mutaflor® Suspension
6 Role Of Saccharomyces Boulardii In Diarrhea Dominant Irritable Bowel Syndrome Unknown status NCT00543478 Phase 4 Saccharomyces boulardii;Methyl cellulose powder (low viscosity)
7 Effect of a Mixture of Probiotics, Lactibiane Tolérance® on Intestinal Permeability in Individuals Suffering From Irritable Bowel Syndrome With Diarrheal Predominance Unknown status NCT02728063 Phase 4
8 The Efficacy of Hydrolyzed Guar Gum ( PHGG) in the Treatment of Patients With Irritable Bowel Syndrome- a Double Blind, Placebo - Controlled, Randomized Study Unknown status NCT01779765 Phase 4
9 Polyethylene Glycol for Childhood Constipation Unknown status NCT01875744 Phase 4 Polyethylene glycol 4000
10 Phase 4 Study of Effects of Dexmedetomidine on Prevention of Side Effects of Hemabate in Cesarean Section Patients Unknown status NCT02220361 Phase 4 placebo;low dose dexmedetomidine;high dose dexmedetomidine
11 The Effect of Probiotics on the Rate of Recovery of Inflammatory Bowel Disease Exacerbation (Crohn's Disease) and Markers of Inflammation Unknown status NCT01765998 Phase 4 Probiotic;Placebo
12 The Role of Short-course Ceftriaxone Therapy in the Treatment of Severe Nontyphoidal Salmonella Enterocolitis Unknown status NCT01278017 Phase 4 ceftriaxone
13 Adherence to Therapy in COPD Patients Under Dose Escalation of Roflumilast Unknown status NCT02018432 Phase 4 Roflumilast escalation dosage;Roflumilast conventional dosage
14 Effect of Ramosetron on Postoperative Restoration of Bowel Motility After Gynecological Laparoscopic Surgery Unknown status NCT02849483 Phase 4 Ramosetron;Normal saline
15 Effect of Ramosetron on Bowel Motility and PONV After Laparoscopic Stomach and Colorectal Resection Unknown status NCT01427127 Phase 4 Ramosetron
16 Irinotecan Plus Thalidomide in Second Line Advanced Gastric Cancer : A Multicenter, Randomized, Controlled and Prospective Trial Unknown status NCT02401971 Phase 4 Thalidomide;CPT-11
17 Randomized, Double Blind, Placebo Control Trial to Evaluate the Efficacy of Wu-Chu-Yu Tang on Gastroesophageal Reflux Disease (GERD) Unknown status NCT01822106 Phase 4
18 Application of Pinaverium Bromide in the Treatment of Patients With Post-cholecystectomy Sphincter of Oddi Dysfunction (SOD): A Randomized, Controlled and Multicenter Clinical Study Unknown status NCT02833103 Phase 4 Danshu Capsules;Pinaverium Bromide
19 Assessment of Analgesic Efficacy and Safety of Intravenous Hyoscine-N-Butylbromide in Patients With Abdominal Colic Associated With Acute Gastroenteritis; a Randomized, Double-blind, Placebo Controlled Study Unknown status NCT02508142 Phase 4 Hyoscine-N-Butylbromide
20 The Clinical Use of Probiotics in the Uremia Patients Under Chronic Peritoneal Dialysis Unknown status NCT01076426 Phase 4 Pro-biotics
21 Bacteria and Cytokines as Factors Modulating Visceral Afferent Processing in Irritable Bowel Syndrome: Manipulation of Intestinal Bacteria and Mucosal Cytokines by Probiotic Therapy and the Effect on Visceral Hypersensitivity Unknown status NCT00418340 Phase 4 probiotic (bacterial/dietary supplement)
22 The Hypotensive Effect of Simvastatin in Hypertensive Patients: a Placebo-controlled Randomized Clinical Trial With 24-h Ambulatory Blood Pressure Monitoring Unknown status NCT02072382 Phase 4 Metformin;Placebo
23 Adjunct Methadone to Decrease the Duration of Mechanical Ventilation in the Medical Intensive Care Unit Unknown status NCT02025855 Phase 4 Methadone;Placebo
24 Effects of N-Acetyl-Cysteine on Oxidative Stress Biomarkers in Bipolar Patients With and Without Tobacco Use Disorder Unknown status NCT02252341 Phase 4
25 Evaluation Whether Higher Retention Rate is in Those of Combined Methadone With N-Acetyl-Cysteine Compared to Those With Methadone Alone During a Six-month Study Unknown status NCT01047956 Phase 4 Methadone; NAC;Methadone
26 Metformin for Weight Control in Adolescents Taking Atypical Antipsychotics- Double Blind Placebo Controlled Study Unknown status NCT00845936 Phase 4 Metformin
27 An Pilot Study to Assess the Efficacy of Intravenous Iron Isomaltoside 1000 (Monofer®) in the Management of Anaemia Associated With the Palliative Management of Oesophagogastric Adenocarcinoma Unknown status NCT01927328 Phase 4 Iron isomaltoside 1000
28 Metabolic, Cardiovascular and Body Composition Effects of Sandostatin LAR® Therapy of Acromegaly, Effect of Reduction of Serum Insulin-like Growth Factor 1 (IGF-1) Levels Into a New Normative Range Unknown status NCT01424241 Phase 4 Sandostatin LAR
29 Treatment With Acetyl-Choline Esterase Inhibitors in Children With Autism Unknown status NCT01098383 Phase 4 Acetyl-Choline Esterase Inhibitors and Choline supplements;Indistinguishable placebo tablets, matching both donepezil and choline
30 An Open Pilot Study to Evaluate the Efficacy and Safety, Tolerability of Raltegravir(RAL)in Treatment-experienced HIV-1 Infected Adult Chinese Patients Unknown status NCT01201239 Phase 4 raltegravir
31 COLITIS: Clostridial Infection and Oral Lavage -Improving Treatment Before Illness Becomes Severe Unknown status NCT01630096 Phase 4 Nu-Lytely
32 Evaluation of the Efficacy in Decreasing Iron Absorption in Patients With Congenital Dyserythropoietic Anemia Type I by Treatment With LOSEC Unknown status NCT01795794 Phase 4 omeprazole
33 Randomized Cross-Over Trial of Captafer® vs. Oral Iron Sulfate in the Treatment of Iron Deficiency Anemia in Patients With Inflammatory Bowel Disease Unknown status NCT02774057 Phase 4 Captafer®;Iron Sulfate
34 Adverse Effects of Glucocorticoid Therapy on Bone in Childhood Crohn's Disease Unknown status NCT00609752 Phase 4 prednisolone
35 A Phase IV 48 Week, Open Label, Pilot Study of Darunavir Boosted by Cobicistat in Combination With Rilpivirine to Treat HIV+ Naïve Subjects (PREZENT) Unknown status NCT02404233 Phase 4 darunavir/cobicistat;rilpivirine
36 Multicenter Study Evaluating the Efficacy of Dicopeg Junior in Comparison With Lactulose for the Treatment of Functional Constipation in Children Aged 6 Months to 6 Years. A Prospective, Randomized Study. Unknown status NCT03177434 Phase 4 polyethylene glycols (PEG) 3350;Lactulose Oral Product
37 Prospective, Interventional, Single Arm Study in Outpatients Undergoing Sigmoidoscopy for Evaluation of Efficacy and Safety of Kleen Enema 120ml (Phosphate Enema) Unknown status NCT02386904 Phase 4 Phosphate Enema (Kleen® Enema)
38 ASSESSMENT OF GH-IGF1 AXIS AND TO STUDY RESPONSE TO GH THERAPY IN CHILDREN WITH CML IN REMISSION HAVING GH DEFICIENCY Unknown status NCT01901666 Phase 4 Growth Hormone
39 Efficacy of Diosmectite (Smecta®) in the Treatment of Acute Diarrhoea in Adults. A Multicentre, Randomised, Double Blind, Placebo Controlled, Parallel Groups Study. Completed NCT00276328 Phase 4 Diosmectite (Smecta®)
40 Efficacy of Diosmectite (Smecta®) in the Symptomatic Treatment of Acute Diarrhoea in Adults. A Multicentre, Randomized, Double Blind Placebo Controlled, Parallel, Groups Study Completed NCT02704091 Phase 4 Smecta;Smecta placebo
41 Efficacy and Mode of Action of Mesalazine in the Treatment of Diarrhoea-predominant Irritable Bowel Syndrome (IBS-D). Completed NCT01316718 Phase 4 Mesalazine;Placebo
42 Ondansetron for the Treatment of IBS With Diarrhoea (IBS-D): Identifying the "Responder" Completed NCT00745004 Phase 4 Ondansetron;Placebo
43 Validation of Stimulated ∆FGF19 for Diagnosing Bile Acid Diarrhoea Completed NCT03059537 Phase 4 Oral chenodeoxycholic acid stimulation
44 A Randomised Placebo Controlled Trial of "Follow on" Rifaximin for the Prevention of Relapse of Clostridium Associated Diarrhoea Completed NCT01670149 Phase 4 Rifaximin;Placebo
45 Introduction of New Hypo-Osmolar ORS (Recommended by WHO) for Routine Use in the Management of Diarrhoeal Diseases – A Phase IV Surveillance Study Completed NCT00490932 Phase 4 Hypo-osmolar ORS
46 A Community Based Intervention and Evaluation of the Impact of Social Marketing of a Diarrhea Management Pack(Comprising of Low Osmolality ORS, Zinc Tablets, Water Purification Tablets and Pictorial Chart) on Childhood Diarrhea. Completed NCT00942812 Phase 4
47 Introduction of New Hypo-osmolar ORS Into Routine Use in the Management of Diarrhoeal Disease: a Phase IV Clinical Surveillance. Completed NCT00244777 Phase 4 Hypo-osmolar ORS
48 Immune Response After Inactivated Oral Cholera Vaccine (Dukoral) in Renal Transplant Recipients Completed NCT01109914 Phase 4
49 STOP Trial - Sandostatin LAR Depot Trial for the Optimum Prevention of Chemotherapy Induced Diarrhea Completed NCT00050635 Phase 4 Sandostatin LAR Depot
50 Post-marketing Clinical Study of Ramosetron Hydrochloride (Irribow Tablets) - Double-blind, Parallel-group Comparative Study in Patients (Male) With Diarrhea-predominant Irritable Bowel Syndrome Completed NCT01225237 Phase 4 Ramosetron;Placebo

Search NIH Clinical Center for Diarrhea

Cochrane evidence based reviews: diarrhea

Genetic Tests for Diarrhea

Genetic tests related to Diarrhea:

# Genetic test Affiliating Genes
1 Diarrhea 29

Anatomical Context for Diarrhea

MalaCards organs/tissues related to Diarrhea:

40
Colon, Testes, Breast, Lung, Small Intestine, Liver, Kidney

Publications for Diarrhea

Articles related to Diarrhea:

(show top 50) (show all 56238)
# Title Authors PMID Year
1
Expanded table: antibiotics for treatment of travelers' diarrhea. 61 42
31599873 2019
2
Interventions to improve disposal of child faeces for preventing diarrhoea and soil-transmitted helminth infection. 61 42
31549742 2019
3
Advice for travelers. 42
31599872 2019
4
Clostridioides difficile infection in the Asia-Pacific region. 61
31873046 2020
5
Fenfluramine hydrochloride for the treatment of seizures in Dravet syndrome: a randomised, double-blind, placebo-controlled trial. 61
31862249 2020
6
Shiga toxin-producing Escherichia coli isolates from red deer (Cervus elaphus), roe deer (Capreolus capreolus) and fallow deer (Dama dama) in Poland. 61
31703865 2020
7
Myenteric networks of interstitial cells of Cajal are reduced in horses with inflammatory bowel disease. 61
31397916 2020
8
Practices and opinions of New Zealand beef cattle farmers towards bovine viral diarrhoea control in relation to real and perceived herd serological status. 61
31722187 2020
9
Reversible splenial lesion in a patient with new-onset refractory status epilepticus (NORSE). 61
31909228 2020
10
Cortex Phellodendri extract's anti-diarrhea effect in mice related to its modification of gut microbiota. 61
31884345 2020
11
Cryptosporidium and Giardia in Ruminants. 61
32029186 2020
12
Upregulation of the type I interferon pathway in feedlot cattle persistently infected with bovine viral diarrhea virus. 61
31926963 2020
13
Individual and community-level risk factors in under-five children diarrhea among agro-ecological zones in southwestern Ethiopia. 61
31978740 2020
14
Household coping strategies associated with unreliable water supplies and diarrhea in Ecuador, an upper-middle-income country. 61
31739243 2020
15
Galloyl flavonoids from Acacia farnesiana pods possess potent anthelmintic activity against Haemonchus contortus eggs and infective larvae. 61
31739102 2020
16
Swine acute diarrhea syndrome coronavirus (SADS-CoV) antagonizes interferon-β production via blocking IPS-1 and RIG-I. 61
31884203 2020
17
Characterization of Circulating Clostridium difficile Strains, Host Response and Intestinal Microbiome in Hospitalized Children With Diarrhea. 61
31876614 2020
18
Genetic characterization and phylogenetic analysis of porcine deltacoronavirus (PDCoV) in Shandong Province, China. 61
31962065 2020
19
Congenital Diarrheal Syndromes. 61
32000931 2020
20
Astringent drugs for bleedings and diarrhoea: The history of Cynomorium coccineum (Maltese Mushroom). 61
31678417 2020
21
Recurrent Metabolic Alkalosis in a Cystic Fibrosis Patient: Coexistence with Congenital Chloride Diarrhea. 61
31976143 2020
22
Genetic lineage of genogroup I norovirus identified among children with diarrhoea in Niger-Delta region, Nigeria. 61
31774008 2020
23
Fulvestrant plus capivasertib versus placebo after relapse or progression on an aromatase inhibitor in metastatic, oestrogen receptor-positive breast cancer (FAKTION): a multicentre, randomised, controlled, phase 2 trial. 61
32035020 2020
24
A Spanish case-control study in <5 year-old children reveals the lack of association between MLB and VA astrovirus and diarrhea. 61
32020041 2020
25
Impact of Daily Preventive Zinc or Therapeutic Zinc Supplementation for Diarrhea on Plasma Biomarkers of Environmental Enteric Dysfunction among Rural Laotian Children: A Randomized Controlled Trial. 61
31889508 2020
26
Cryptosporidium Infection Increases the Risk for Chronic Diarrhea Among People Living With HIV in Southeast Asia: A Systematic Review and Meta-Analysis. 61
32037854 2020
27
Impairment of electroneutral Na+ transport and associated downregulation of NHE3 contributes to the development of diarrhea following in vivo challenge with Brachyspira spp. 61
31760765 2020
28
Metronidazole-sensitive organisms in children with severe acute malnutrition: an evaluation of the indication for empiric metronidazole treatment. 61
31185294 2020
29
Idiopathic chronic diarrhea associated with dysbiosis in a captive cynomolgus macaque (Macaca fascicularis). 61
31642533 2020
30
The effect of acute malnutrition on enteric pathogens, moderate-to-severe diarrhoea, and associated mortality in the Global Enteric Multicenter Study cohort: a post-hoc analysis. 61
31981554 2020
31
Risk factors and clinical characteristics of tacrolimus-induced acute nephrotoxicity in children with nephrotic syndrome: a retrospective case-control study. 61
31745585 2020
32
Similarities in Clinical and Psychosocial Characteristics of Functional Diarrhea and Irritable Bowel Syndrome With Diarrhea. 61
31442602 2020
33
Canadian Association of Gastroenterology Clinical Practice Guideline on the Management of Bile Acid Diarrhea. 61
32010878 2020
34
Oral Defense: How Oral Rehydration Solutions Revolutionized the Treatment of Toxigenic Diarrhea. 61
31900719 2020
35
Peroxiredoxin 1 as an inflammatory marker in diarrhea-predominant and postinfectious irritable bowel syndrome. 61
31613423 2020
36
Workflow optimization for syndromic diarrhea diagnosis using the molecular Seegene Allplex™ GI-Bacteria(I) assay. 61
32026192 2020
37
Development and Pathophysiology of Oral Rehydration Therapy for the Treatment for Diarrhea. 61
31659613 2020
38
Use of intestine-related biomarkers for detecting intestinal epithelial damage in neonatal calves with diarrhea. 61
31985285 2020
39
Co-infection status of porcine circoviruses (PCV2 and PCV3) and porcine epidemic diarrhea virus (PEDV) in pigs with watery diarrhea in Henan province, central China. 61
32036077 2020
40
Origin and transmission of bovine viral diarrhea virus type 1 in China revealed by phylodynamic analysis. 61
31809973 2020
41
Rapid manipulation of the porcine epidemic diarrhea virus genome by CRISPR/Cas9 technology. 61
31712093 2020
42
Assessment of environmental exposure factors on child diarrhea and systemic inflammation in the Eastern Cape. 61
31707177 2020
43
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Variations for Diarrhea

ClinVar genetic disease variations for Diarrhea:

6 ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 WNT2B NM_024494.3(WNT2B):c.205C>T (p.Arg69Ter)SNV Pathogenic 545432 rs370244148 1:113057518-113057518 1:112514896-112514896
2 RASL12 , SLC51B NM_178859.4(SLC51B):c.84del (p.Arg29fs)deletion Likely pathogenic 804474 15:65342421-65342421 15:65050083-65050083

Expression for Diarrhea

Search GEO for disease gene expression data for Diarrhea.

Pathways for Diarrhea

GO Terms for Diarrhea

Cellular components related to Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 10.07 TMPRSS15 SPINT2 SLC9A3 SLC26A3 SI MME
2 cell surface GO:0009986 9.63 SLC9A3 MME EPCAM CD40LG ANTXR2 ABCB1
3 apical plasma membrane GO:0016324 9.35 SLC9A3 SLC26A3 SI EPCAM ABCB1
4 brush border GO:0005903 8.92 TMPRSS15 SLC9A3 SI MME

Biological processes related to Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of interleukin-4 production GO:0032753 8.96 FOXP3 CD40LG
2 digestion GO:0007586 8.8 SST GUCY2C CCK

Sources for Diarrhea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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