MCID: DST006
MIFTS: 46

Diastolic Heart Failure

Categories: Cardiovascular diseases

Aliases & Classifications for Diastolic Heart Failure

MalaCards integrated aliases for Diastolic Heart Failure:

Name: Diastolic Heart Failure 12 15
Heart Failure, Diastolic 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:9775
ICD10 33 I50.30
ICD9CM 35 428.3 428.30
MeSH 44 D054144
UMLS 73 C1135196

Summaries for Diastolic Heart Failure

MalaCards based summary : Diastolic Heart Failure, also known as heart failure, diastolic, is related to systolic heart failure and pulmonary hypertension, primary, 1. An important gene associated with Diastolic Heart Failure is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are Development Angiotensin activation of ERK and MicroRNAs in cardiomyocyte hypertrophy. The drugs Spironolactone and Eplerenone have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and testes, and related phenotypes are Reduced mammosphere formation and behavior/neurological

Related Diseases for Diastolic Heart Failure

Diseases related to Diastolic Heart Failure via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 109)
# Related Disease Score Top Affiliating Genes
1 systolic heart failure 30.2 ACE NPPB
2 pulmonary hypertension, primary, 1 30.1 NPPA NPPB
3 mitral valve insufficiency 30.1 ACE NPPA NPPB
4 congestive heart failure 30.1 ACE AGTR1 NPPA NPPB
5 hypertrophic cardiomyopathy 29.9 ACE ANKRD1 MYBPC3
6 renal hypertension 29.9 ACE AGTR1 NPPB
7 pulmonary hypertension 29.8 ACE NOS3 NPPA NPPB
8 atrial standstill 1 29.8 ACE MYBPC3 NPPB
9 diabetes mellitus 29.8 ACE AGT AGTR1 NOS3
10 hypertensive heart disease 29.8 ACE AGT AGTR1 MMP2 NPPB
11 sleep apnea 29.6 ACE NOS3 NPPB
12 pulmonary edema 29.6 ACE NOS3 NPPA NPPB
13 autosomal dominant polycystic kidney disease 29.6 ACE AGT NOS3
14 atrial fibrillation 29.6 ACE AGT AGTR1 MYBPC3 NPPA NPPB
15 kidney disease 29.6 ACE AGT AGTR1 NOS3 NPPA NPPB
16 arteries, anomalies of 29.5 ACE AGT AGTR1 NOS3 NPPB
17 chronic kidney failure 29.5 ACE AGT AGTR1 NOS3 NPPA NPPB
18 coronary artery anomaly 29.5 ACE AGTR1 NOS3 NPPA NPPB
19 pre-eclampsia 29.4 AGT AGTR1 NOS3 NPPA
20 heart disease 29.1 ACE AGTR1 ANKRD1 MYBPC3 NOS3 NPPA
21 myocardial infarction 28.7 ACE AGT AGTR1 MMP2 NOS3 NPPA
22 pediatric hypertension 10.2 ACE AGT
23 hypertensive nephropathy 10.2 ACE AGTR1
24 meningococcal infection 10.2 AGT AGTR1
25 hypoaldosteronism 10.2 ACE NPPA
26 left bundle branch hemiblock 10.2 ACE NPPB
27 aortic valve insufficiency 10.2 ACE NPPB
28 nephrosclerosis 10.2 ACE AGTR1
29 hepatorenal syndrome 10.1 ACE NPPA
30 pure autonomic failure 10.1 ACE NPPA
31 mitral valve stenosis 10.1 NPPA NPPB
32 syncope 10.1 NPPA NPPB
33 posterior urethral valves 10.1 ACE AGT AGTR1
34 microvascular complications of diabetes 3 10.1 ACE AGT AGTR1
35 anuria 10.1 ACE AGT AGTR1
36 fibromuscular dysplasia 10.1 ACE AGT AGTR1
37 renal tubular dysgenesis 10.1 ACE AGT AGTR1
38 heart conduction disease 10.1 ACE NPPB
39 constrictive pericarditis 10.1
40 pericarditis 10.1
41 amyloidosis 10.1
42 renal dysplasia 10.1 ACE AGT AGTR1
43 end stage renal failure 10.1 ACE AGT AGTR1
44 otosclerosis 10.1 ACE AGT AGTR1
45 interstitial nephritis 10.1 ACE AGT
46 pericardial effusion 10.1 NPPA NPPB
47 anterolateral myocardial infarction 10.1 ACE NPPA NPPB
48 syndrome of inappropriate antidiuretic hormone 10.1 ACE NPPA NPPB
49 idiopathic edema 10.1 ACE NPPA NPPB
50 familial hypertension 10.1 AGT AGTR1 NPPA

Graphical network of the top 20 diseases related to Diastolic Heart Failure:



Diseases related to Diastolic Heart Failure

Symptoms & Phenotypes for Diastolic Heart Failure

GenomeRNAi Phenotypes related to Diastolic Heart Failure according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.02 AGTR1 ANKRD1 MADD MMP2 MYBPC3

MGI Mouse Phenotypes related to Diastolic Heart Failure:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.87 ACE AGT AGTR1 ANKRD1 MADD MYBPC3
2 cardiovascular system MP:0005385 9.86 ACE AGT AGTR1 ANKRD1 MMP2 MYBPC3
3 homeostasis/metabolism MP:0005376 9.81 ACE AGT AGTR1 ANKRD1 MADD MMP2
4 muscle MP:0005369 9.43 AGT ANKRD1 MMP2 MYBPC3 NOS3 NPPA
5 renal/urinary system MP:0005367 9.02 ACE AGT AGTR1 NOS3 NPPA

Drugs & Therapeutics for Diastolic Heart Failure

Drugs for Diastolic Heart Failure (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 100)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Spironolactone Approved Phase 4,Phase 3,Phase 2,Not Applicable 52-01-7, 1952-01-7 5833
2
Eplerenone Approved Phase 4,Phase 2,Phase 3,Not Applicable 107724-20-9 443872 150310
3
Angiotensin II Approved, Investigational Phase 4,Phase 3 11128-99-7, 68521-88-0, 4474-91-3 172198 65143
4
Valsartan Approved, Investigational Phase 4,Phase 3 137862-53-4 60846
5
Nebivolol Approved, Investigational Phase 4 99200-09-6, 152520-56-4, 118457-14-0 71301
6
Regadenoson Approved, Investigational Phase 4 313348-27-5 219024
7
Adenosine Approved, Investigational Phase 4 58-61-7 60961
8
Ambrisentan Approved, Investigational Phase 4 177036-94-1 6918493
9
Exenatide Approved, Investigational Phase 4 141758-74-9 15991534
10
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
11 Estradiol valerate Approved, Investigational, Vet_approved Phase 4 979-32-8
12
Polyestradiol phosphate Approved Phase 4 28014-46-2
13
Norethindrone Approved Phase 4 68-22-4 6230
14
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 77-92-9 311
15 Hypolipidemic Agents Phase 4,Not Applicable
16 Calcium, Dietary Phase 4,Phase 2,Not Applicable
17 Atorvastatin Calcium Phase 4,Not Applicable 134523-03-8
18 Anticholesteremic Agents Phase 4,Not Applicable
19 Antimetabolites Phase 4,Not Applicable
20 Lipid Regulating Agents Phase 4,Not Applicable
21 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4,Not Applicable
22 Diuretics, Potassium Sparing Phase 4,Phase 3,Phase 2,Not Applicable
23 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
24 Natriuretic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
25 Phosphodiesterase Inhibitors Phase 4,Phase 3,Phase 2
26 Vasodilator Agents Phase 4,Phase 3,Phase 2,Not Applicable
27 Phosphodiesterase 5 Inhibitors Phase 4,Phase 3,Phase 2
28 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
29 diuretics Phase 4,Phase 3,Phase 2,Not Applicable
30 Mineralocorticoids Phase 4,Phase 3,Phase 2,Not Applicable
31 Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
32 Mineralocorticoid Receptor Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
33 Angiotensin Receptor Antagonists Phase 4,Phase 3
34 Antihypertensive Agents Phase 4,Phase 3,Not Applicable
35 Angiotensin II Type 1 Receptor Blockers Phase 4,Phase 3
36 Angiotensinogen Phase 4,Phase 3
37 Sildenafil Citrate Phase 4,Phase 3,Phase 2 171599-83-0
38 Citrate Phase 4,Phase 3,Phase 2
39 Adrenergic beta-Antagonists Phase 4,Not Applicable
40 Natriuretic Peptide, Brain Phase 4,Phase 1,Phase 2,Not Applicable
41 Hypoglycemic Agents Phase 4,Not Applicable
42 Adrenergic beta-Agonists Phase 4
43 Adrenergic Agents Phase 4
44 Adrenergic Agonists Phase 4
45 Neurotransmitter Agents Phase 4
46 LCZ 696 Phase 4,Phase 3
47 Incretins Phase 4
48 glucagon Phase 4
49 Glucagon-Like Peptide 1 Phase 4
50 Contraceptive Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 97)
# Name Status NCT ID Phase Drugs
1 Effects of Atorvastatin Treatment on Left Ventricular Diastolic Function in Peritoneal Dialysis Patients Unknown status NCT01503671 Phase 4 Atorvastatin
2 Novel Treatment for Diastolic Heart Failure in Women Completed NCT00206232 Phase 4 Spironolactone
3 Aldosterone Antagonism in Diastolic Heart Failure Completed NCT00108251 Phase 4 Eplerenone;Placebo
4 A Trial of Fimasartan for Early Diastolic Heart Failure Completed NCT01691118 Phase 4 Fimasartan;Antihypertensive treatment
5 Impacts of Aldosterone Blockade on Myocardial Remodeling in Hypertensive Patients With Diastolic Failing Heart Completed NCT01944384 Phase 4 aldactone
6 Efficacy and Safety of Valsartan Versus Placebo on Exercise Tolerance in Patients With Heart Failure Completed NCT00171106 Phase 4 valsartan
7 SIDAMI - Sildenafil and Diastolic Dysfunction After Acute Myocardial Infarction (AMI) Completed NCT01046838 Phase 4 Sildenafil;Placebo
8 Improving Treatment Personalization of Pulmonary Hypertension Associated With Diastolic Heart Failure Recruiting NCT02053246 Phase 4 Nebivolol
9 Myocardial Perfusion, Oxidative Metabolism, and Fibrosis in HFpEF Recruiting NCT02589977 Phase 4 regadenoson
10 Circulating NEP and NEP Inhibition Study in Heart Failure With Preserved Ejection Fraction Recruiting NCT03506412 Phase 4 Entresto™ 49Mg-51 mg tablet
11 Reversing Endothelial and Diastolic Dysfunction and Improving Collagen Turnover in Diastolic Heart Failure Terminated NCT00293150 Phase 4 Eplerenone
12 Use of Nesiritide in the Management of Acute Diastolic Heart Failure Terminated NCT00083772 Phase 4 Nesiritide
13 Safety and Efficacy Trial to Treat Diastolic Heart Failure Using Ambrisentan Terminated NCT00840463 Phase 4 Ambrisentan
14 Evaluating the Use of Exenatide in People With Type 2 Diabetes and Diastolic Heart Failure Terminated NCT00799435 Phase 4 Exenatide
15 Estrogen Diastolic Heart Failure Terminated NCT02693002 Phase 4 Estradiol/Norethindrone acetate;Placebo
16 Denervation of the renAl sympathetIc nerveS in hearT Failure With nOrmal Lv Ejection Fraction Unknown status NCT01583881 Phase 2, Phase 3
17 A Randomized Trial of Udenafil Therapy in Patients With Heart Failure With Preserved Ejection Fraction [ULTIMATE-HFpEF] Unknown status NCT01599117 Phase 3 Placebo;Udenafil (Zydena)
18 Evaluating the Effectiveness of Sildenafil at Improving Health Outcomes and Exercise Ability in People With Diastolic Heart Failure (The RELAX Study) Completed NCT00763867 Phase 3 Placebo;Sildenafil
19 Phosphodiesterase-5 (PDE5) Inhibition and Pulmonary Hypertension in Diastolic Heart Failure Completed NCT01156636 Phase 2, Phase 3 Sildenafil;Placebo
20 Evaluation of Enalapril Versus Placebo in Patients With Diastolic Heart Failure Completed NCT01411735 Phase 3 Enalapril;placebo
21 PIE II: Pharmacological Intervention in the Elderly II Completed NCT00123955 Phase 3 Spironolactone;Placebo
22 Safety and Efficacy of Bosentan in Patients With Diastolic Heart Failure and Secondary Pulmonary Hypertension Completed NCT00820352 Phase 3 bosentan;placebo
23 Aldosterone Antagonist Therapy for Adults With Heart Failure and Preserved Systolic Function Completed NCT00094302 Phase 3 Spironolactone;Placebo
24 Efficacy and Safety of LCZ696 Compared to Valsartan, on Morbidity and Mortality in Heart Failure Patients With Preserved Ejection Fraction Active, not recruiting NCT01920711 Phase 3 LCZ696;Valsartan
25 Study of the Effect of Eplerenone on Heart Function in Women Receiving Anthracycline Chemotherapy for Breast Cancer Terminated NCT01708798 Phase 2, Phase 3 Eplerenone;Placebo
26 Study of Nesiritide in Diastolic Heart Failure. Completed NCT00309868 Phase 1, Phase 2 neseritide
27 A Study of the Effectiveness of Sitaxsentan Sodium in Patients With Diastolic Heart Failure Completed NCT00303498 Phase 2 Sitaxsentan sodium;Placebo
28 The DIAMOND Study: Distensibility Improvement And Remodeling in Diastolic Heart Failure Completed NCT00043836 Phase 2 ALT-711
29 Ranolazine in Diastolic Heart Failure Completed NCT01163734 Phase 2 Ranolazine
30 Perhexiline Therapy in Heart Failure With Preserved Ejection Fraction Syndrome Completed NCT00839228 Phase 2 Perhexiline;Placebo
31 Pharmacokinetics, Pharmacodynamics, and Impact of Inorganic Nitrate on Exercise in HFpEF Completed NCT02256345 Phase 2 KNO3;KCl
32 Natriuretic Peptide System as Therapy in Human Preclinical Left Ventricle Dysfunction Completed NCT00387621 Phase 1, Phase 2 Nesiritide;Placebo;Saline
33 Interleukin-1 Blockade in HF With Preserved EF Completed NCT02173548 Phase 2 Anakinra;Placebo
34 CoQ10 and D-ribose in Patients With Diastolic Heart Failure Recruiting NCT03133793 Phase 2 CoQ10;D-Ribose Oral Powder
35 Beginning a Randomized Evaluation of the AGE Breaker Alagebrium in Diastolic Heart Failure (BREAK-DHF-I) Terminated NCT00662116 Phase 2 alagebrium;placebo
36 A Randomized Double-Blind, Placebo-Controlled, Multiple-Dose Study to Evaluate the Effects of Alagebrium on Exercise in Subjects With Diastolic Heart Failure Terminated NCT01913301 Phase 2 Alagebrium
37 The Use of Ranolazine for Atrial Fibrillation and Diastolic Heart Failure Terminated NCT01887353 Phase 2 Ranolazine;Placebo
38 A Study to Test the Effects of Riociguat in Patients With Pulmonary Hypertension Associated With Left Ventricular Diastolic Dysfunction Terminated NCT01172756 Phase 2 Riociguat (BAY63-2521);Riociguat (BAY63-2521);Riociguat (BAY63-2521);Placebo
39 If Channel Blockade With Ivabradine in Patients With Diastolic Heart Failure Withdrawn NCT00757055 Phase 2 Ivabradine;Placebo
40 BNP Testing in Patients With SOB on Presentation to ED Unknown status NCT00163709 Phase 1
41 Physiological Effects of Grape Seed Extract in Diastolic Heart Failure Completed NCT01185067 Phase 1 grape seed extract (MegaNatural BP, Polyphenolics, Inc.)
42 Diastolic Heart Failure Management by Nifedipine Unknown status NCT01157481 Not Applicable Conventional therapy plus nifedipine;Conventional therapy
43 Assessment of Functional Capacity and Inflammatory Markers in Women With Heart Failure With Preserved Ejection Fraction Unknown status NCT02649400
44 Validation of New Non-Invasive Parameters of Diastolic Suction in the Left Ventricle Unknown status NCT02315859
45 CORolla™ TAA for Heart Failure and Preserved Ejection Fraction and Diastolic Dysfunction Unknown status NCT01956526 Not Applicable
46 Markers of Oxidative Stress Diastolic Dysfunction Unknown status NCT00846404
47 Renal Denervation in Patients With Heart Failure With Normal LV Ejection Fraction Unknown status NCT02115230 Not Applicable
48 China National Heart Failure Registry Unknown status NCT02079428
49 Effect of Ranolazine on Echocardiographic Indices of Diastolic Dysfunction Unknown status NCT00574756 Not Applicable ranolazine
50 The Metabolic Road to Diastolic Heart Failure: Diastolic Heart Failure Study Completed NCT02446327 Not Applicable

Search NIH Clinical Center for Diastolic Heart Failure

Cochrane evidence based reviews: heart failure, diastolic

Genetic Tests for Diastolic Heart Failure

Anatomical Context for Diastolic Heart Failure

MalaCards organs/tissues related to Diastolic Heart Failure:

41
Heart, Brain, Testes, Endothelial, Kidney, Breast, Lung

Publications for Diastolic Heart Failure

Articles related to Diastolic Heart Failure:

(show top 50) (show all 479)
# Title Authors Year
1
Pulmonary Edema and Diastolic Heart Failure in the Perioperative Period. ( 29607222 )
2018
2
Impact of end stage renal disease on in-hospital outcomes of patients with systolic and diastolic heart failure (insights from the Nationwide Inpatient Sample 2010 to 2014). ( 29887443 )
2018
3
Etiologies, Trends, and Predictors of 30-Day Readmissions in Patients With Diastolic Heart Failure. ( 28648393 )
2017
4
Complexity of pathomechanisms leading to diastolic heart failure in diabetes mellitus - potential field for therapeutic interventions? ( 28934928 )
2017
5
Diastolic heart failure associated with hemangiosarcoma infiltrating left ventricular walls in a dog. ( 29089652 )
2017
6
Age-dependent diastolic heart failure in an in vivo Drosophila model. ( 28328397 )
2017
7
Endomyocardial Fibrosis: A Rare Case of Diastolic Heart Failure in a European Caucasian Elderly Woman. ( 28818409 )
2017
8
Stachydrine ameliorates pressure overload-induced diastolic heart failure by suppressing myocardial fibrosis. ( 28979698 )
2017
9
The role of Ivabradine in Diastolic Heart Failure with preserved Ejection Fraction. A Doppler-Echocardiographic study. ( 29142810 )
2017
10
Exercise training in Diastolic Heart Failure (Ex-DHF): rationale and design of a multicentre, prospective, randomized, controlled, parallel group trial. ( 28516519 )
2017
11
Shared biomarkers between female diastolic heart failure and pre-eclampsia: a systematic review and meta-analysis. ( 28451444 )
2017
12
Interleukin-1 blockade in heart failure with preserved ejection fraction: rationale and design of the Diastolic Heart Failure Anakinra Response Trial 2 (D-HART2). ( 28475816 )
2017
13
Shortness of breath in clinical practice: A case for left atrial function and exercise stress testing for a comprehensive diastolic heart failure workup. ( 29354484 )
2017
14
Deliberations on Diastolic Heart Failure. ( 28029360 )
2016
15
The Stiff Left Atrium Is to Atrial Fibrillation as the Stiff Left Ventricle Is to Diastolic Heart Failure. ( 26966289 )
2016
16
Diastolic Heart Failure Predicted by Left Atrial Expansion Index in Patients with Severe Diastolic Dysfunction. ( 27622475 )
2016
17
Association of ACE gene D polymorphism with left ventricular hypertrophy in patients with diastolic heart failure: a case-control study. ( 26861937 )
2016
18
Clinical effects of combined treatment by optimal dose of furosemide and spironolactone on diastolic heart failure in elderly patients. ( 26998008 )
2016
19
Diastolic heart failure: diagnosis and therapy. ( 26658178 )
2016
20
Impaired Right Ventricular-Pulmonary Arterial Coupling and Effect of Sildenafil in Heart Failure With Preserved Ejection Fraction: An Ancillary Analysis From the Phosphodiesterase-5 Inhibition to Improve Clinical Status And Exercise Capacity in Diastolic Heart Failure (RELAX) Trial. ( 27072860 )
2016
21
Pathophysiological role of oxidative stress in systolic and diastolic heart failure and its therapeutic implications. ( 26142467 )
2015
22
Complete heart block with diastolic heart failure and pulmonary edema secondary to enlarging previously diagnosed thrombosed aneurysm of sinus of valsalva in a patient with history of autosomal dominant polycystic kidney disease. ( 25861484 )
2015
23
Lowering body weight in obese mice with diastolic heart failure improves cardiac insulin sensitivity and function: implications for the obesity paradox. ( 25524917 )
2015
24
Constrictive pericarditis-a curable diastolic heart failure. ( 26440983 )
2015
25
Galectin-3 in heart failure with preserved ejection fraction. A RELAX trial substudy (Phosphodiesterase-5 Inhibition to Improve Clinical Status and Exercise Capacity in Diastolic Heart Failure). ( 25742762 )
2015
26
Increased Prevalence of Diastolic Heart Failure in Patients with Rheumatoid Arthritis Correlates with Active Disease, but Not with Treatment Type. ( 26373561 )
2015
27
Successful resection of a huge metastatic liposarcoma in the pericardium resulting in improvement of diastolic heart failure: a case report. ( 26366370 )
2015
28
The association and interaction analysis of hypertension and diabetes mellitus on diastolic heart failure in a high-risk population. ( 26885071 )
2015
29
Sustained Toll-Like Receptor 9 Activation Promotes Systemic and Cardiac Inflammation, and Aggravates Diastolic Heart Failure in SERCA2a KO Mice. ( 26461521 )
2015
30
Impact of the renin-angiotensin system and inflammatory gene polymorphisms on diastolic heart failure. ( 24530241 )
2014
31
Utility of lower limb positive pressure test for diagnosis of diastolic heart failure: a case report. ( 25264062 )
2014
32
Increased reactive oxygen species, metabolic maladaptation, and autophagy contribute to pulmonary arterial hypertension-induced ventricular hypertrophy and diastolic heart failure. ( 25267798 )
2014
33
Genetics of systolic and diastolic heart failure. ( 25380161 )
2014
34
Digoxin and 30-day All-cause Hospital Admission in Older Patients with Chronic Diastolic Heart Failure. ( 24067296 )
2014
35
Atorvastatin ameliorates cardiac fibrosis and improves left ventricular diastolic function in hypertensive diastolic heart failure model rats. ( 24759122 )
2014
36
Acute Hemodynamic Effects of Riociguat in Patients With Pulmonary Hypertension Associated With Diastolic Heart Failure (DILATE-1): A Randomized, Double-Blind, Placebo-Controlled, Single-Dose Study. ( 24991733 )
2014
37
Optimising exercise training in prevention and treatment of diastolic heart failure (OptimEx-CLIN): rationale and design of a prospective, randomised, controlled trial. ( 25354950 )
2014
38
CrossTalk opposing view: the late sodium current is not an important player in the development of diastolic heart failure (heart failure with a preserved ejection fraction). ( 24488067 )
2014
39
Myocardial energetics and ubiquinol in diastolic heart failure. ( 25263245 )
2014
40
Case 6/2014--A case of a 61-year-old woman with diastolic heart failure. ( 25590936 )
2014
41
CrossTalk proposal: The late sodium current is an important player in the development of diastolic heart failure (heart failure with a preserved ejection fraction). ( 24488066 )
2014
42
Heart failure with normal ejection fraction, heart failure with preserved ejection fraction, diastolic heart failure, or huff-puff: time for a new taxonomy for hypertensive-metabolic heart failure. ( 25151212 )
2014
43
Constrictive pericarditis--a curable diastolic heart failure. ( 25072910 )
2014
44
Connective tissue growth factor and cardiac diastolic dysfunction: human data from the Taiwan diastolic heart failure registry and molecular basis by cellular and animal models. ( 24464932 )
2014
45
New diagnostic and therapeutic possibilities for diastolic heart failure. ( 24494212 )
2014
46
Socioeconomic factors and mortality in diastolic heart failure. ( 24467732 )
2014
47
Association and predictive value analysis for metabolic syndrome on systolic and diastolic heart failure in high-risk patients. ( 25249273 )
2014
48
Tissue Doppler-derived E/e' ratio as a parameter for assessing diastolic heart failure and as a predictor of mortality in patients with chronic kidney disease. ( 23345995 )
2013
49
Diastolic heart failure: a confusing concept. ( 22961410 )
2013
50
Diastolic Heart Failure in Hypertension: Possible Preventive Benefits of Nebivolol Beyond Lowering Blood Pressure. ( 24371501 )
2013

Variations for Diastolic Heart Failure

Expression for Diastolic Heart Failure

Search GEO for disease gene expression data for Diastolic Heart Failure.

Pathways for Diastolic Heart Failure

GO Terms for Diastolic Heart Failure

Biological processes related to Diastolic Heart Failure according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.83 AGT MADD NPPB
2 negative regulation of cell growth GO:0030308 9.74 AGT NPPA NPPB
3 kidney development GO:0001822 9.73 ACE AGT AGTR1
4 cellular response to mechanical stimulus GO:0071260 9.69 AGT ANKRD1 NPPA
5 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.66 AGT MMP2
6 regulation of cardiac conduction GO:1903779 9.65 AGT NPPA
7 sarcomere organization GO:0045214 9.65 ANKRD1 MYBPC3
8 positive regulation of protein tyrosine kinase activity GO:0061098 9.64 ACE AGT
9 positive regulation of reactive oxygen species metabolic process GO:2000379 9.64 AGT AGTR1
10 positive regulation of blood pressure GO:0045777 9.63 ACE AGT
11 cardiac muscle tissue morphogenesis GO:0055008 9.63 ANKRD1 MYBPC3
12 vasodilation GO:0042311 9.62 AGT NOS3
13 nitric oxide mediated signal transduction GO:0007263 9.62 AGT NOS3
14 positive regulation of cellular protein metabolic process GO:0032270 9.61 AGT AGTR1
15 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.61 AGT AGTR1
16 cell growth involved in cardiac muscle cell development GO:0061049 9.6 AGT NPPA
17 response to muscle stretch GO:0035994 9.59 ANKRD1 NPPA
18 low-density lipoprotein particle remodeling GO:0034374 9.58 AGT AGTR1
19 positive regulation of renal sodium excretion GO:0035815 9.58 AGT NPPB
20 cGMP biosynthetic process GO:0006182 9.55 NPPA NPPB
21 receptor guanylyl cyclase signaling pathway GO:0007168 9.54 NPPA NPPB
22 blood vessel remodeling GO:0001974 9.54 ACE AGT NOS3
23 positive regulation of cholesterol esterification GO:0010873 9.52 AGT AGTR1
24 regulation of vasoconstriction GO:0019229 9.5 ACE AGT AGTR1
25 positive regulation of NAD(P)H oxidase activity GO:0033864 9.49 AGT AGTR1
26 regulation of renal sodium excretion GO:0035813 9.48 AGT AGTR1
27 renin-angiotensin regulation of aldosterone production GO:0002018 9.46 AGT AGTR1
28 regulation of blood vessel diameter by renin-angiotensin GO:0002034 9.43 AGT AGTR1
29 regulation of blood vessel diameter GO:0097746 9.43 ACE AGTR1 NPPB
30 regulation of renal output by angiotensin GO:0002019 9.4 ACE AGT
31 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.33 ACE AGT AGTR1
32 regulation of blood vessel size GO:0050880 9.26 AGT NOS3 NPPA NPPB
33 regulation of blood pressure GO:0008217 9.02 ACE AGT NOS3 NPPA NPPB

Molecular functions related to Diastolic Heart Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.33 AGT NPPA NPPB
2 titin binding GO:0031432 9.26 ANKRD1 MYBPC3
3 hormone receptor binding GO:0051427 8.96 NPPA NPPB
4 bradykinin receptor binding GO:0031711 8.62 ACE AGTR1

Sources for Diastolic Heart Failure

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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