MCID: DST006
MIFTS: 46

Diastolic Heart Failure

Categories: Cardiovascular diseases

Aliases & Classifications for Diastolic Heart Failure

MalaCards integrated aliases for Diastolic Heart Failure:

Name: Diastolic Heart Failure 12 15
Heart Failure, Diastolic 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:9775
ICD10 33 I50.30
ICD9CM 35 428.3 428.30
MeSH 44 D054144
SNOMED-CT 68 418304008
UMLS 73 C1135196

Summaries for Diastolic Heart Failure

MalaCards based summary : Diastolic Heart Failure, also known as heart failure, diastolic, is related to systolic heart failure and congestive heart failure. An important gene associated with Diastolic Heart Failure is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are p70S6K Signaling and Immune response IL-23 signaling pathway. The drugs Spironolactone and Eplerenone have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and brain, and related phenotypes are cardiovascular system and growth/size/body region

Related Diseases for Diastolic Heart Failure

Diseases related to Diastolic Heart Failure via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 104)
# Related Disease Score Top Affiliating Genes
1 systolic heart failure 30.2 ACE NPPB
2 congestive heart failure 30.2 ACE AGTR1 NPPB
3 renal hypertension 29.9 ACE AGTR1 NPPB
4 chronic kidney failure 29.7 ACE AGT AGTR1 NPPB
5 kidney disease 29.7 ACE AGT AGTR1 NPPB
6 atrial standstill 1 29.5 ACE MYBPC3 NPPB
7 hypertrophic cardiomyopathy 29.3 ACE ANKRD1 MYBPC3
8 pulmonary edema 29.3 ACE NOS3 NPPB
9 autosomal dominant polycystic kidney disease 29.0 ACE AGT NOS3
10 sleep apnea 29.0 ACE NOS3 NPPB
11 pulmonary hypertension 29.0 ACE NOS3 NPPB
12 atrial fibrillation 28.7 ACE AGT AGTR1 MYBPC3 NPPB
13 pre-eclampsia 28.7 AGT AGTR1 NOS3
14 diabetes mellitus 28.7 ACE AGT AGTR1 NOS3
15 hypertensive heart disease 28.6 ACE AGT AGTR1 MMP2 NPPB
16 diabetes mellitus, noninsulin-dependent 28.3 ACE AGT AGTR1 NOS3
17 arteries, anomalies of 28.1 ACE AGT AGTR1 NOS3 NPPB
18 coronary artery anomaly 28.0 ACE AGT AGTR1 NOS3 NPPB
19 heart disease 27.1 ACE AGTR1 ANKRD1 MYBPC3 NOS3 NPPB
20 myocardial infarction 26.7 ACE AGT AGTR1 MMP2 NOS3 NPPB
21 pediatric hypertension 10.6 ACE AGT
22 hypertensive nephropathy 10.6 ACE AGTR1
23 familial hypertension 10.6 AGT AGTR1
24 meningococcal infection 10.5 AGT AGTR1
25 syndrome of inappropriate antidiuretic hormone 10.5 ACE NPPB
26 aortic valve insufficiency 10.5 ACE NPPB
27 idiopathic edema 10.5 ACE NPPB
28 mitral valve insufficiency 10.4 ACE NPPB
29 interstitial nephritis 10.3 ACE AGT
30 ureteral disease 10.3 ACE CTGF
31 posterior urethral valves 10.3 ACE AGT AGTR1
32 anuria 10.3 ACE AGT AGTR1
33 malignant hypertension 10.2 ACE AGT AGTR1
34 fibromuscular dysplasia 10.2 ACE AGT AGTR1
35 renal tubular dysgenesis 10.2 ACE AGT AGTR1
36 renal dysplasia 10.2 ACE AGT AGTR1
37 end stage renal failure 10.2 ACE AGT AGTR1
38 heart conduction disease 10.2 ACE NPPB
39 hypertension, diastolic 10.2
40 otosclerosis 10.2 ACE AGT AGTR1
41 aging 10.1
42 acute myocardial infarction 10.1 ACE AGTR1 NPPB
43 aortic valve disease 2 10.1 ACE AGT NPPB
44 familial isolated dilated cardiomyopathy 10.1 ANKRD1 MYBPC3
45 nephrosclerosis 10.1 ACE AGTR1 CTGF
46 endotheliitis 10.0
47 vasculogenic impotence 10.0 ACE NOS3
48 angina pectoris 10.0 ACE NOS3
49 constrictive pericarditis 10.0
50 pericarditis 10.0

Graphical network of the top 20 diseases related to Diastolic Heart Failure:



Diseases related to Diastolic Heart Failure

Symptoms & Phenotypes for Diastolic Heart Failure

MGI Mouse Phenotypes related to Diastolic Heart Failure:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.86 MYBPC3 NOS3 ACE AGT AGTR1 ANKRD1
2 growth/size/body region MP:0005378 9.7 MMP2 NOS3 ACE AGT AGTR1 ANKRD1
3 homeostasis/metabolism MP:0005376 9.56 MYBPC3 NOS3 ACE AGT AGTR1 ANKRD1
4 muscle MP:0005369 9.02 MYBPC3 NOS3 AGT ANKRD1 MMP2

Drugs & Therapeutics for Diastolic Heart Failure

Drugs for Diastolic Heart Failure (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 109)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Spironolactone Approved Phase 4,Phase 3,Phase 2,Not Applicable 1952-01-7, 52-01-7 5833
2
Eplerenone Approved Phase 4,Phase 2,Phase 3,Not Applicable 107724-20-9 150310 443872
3
Valsartan Approved, Investigational Phase 4,Phase 3 137862-53-4 60846
4
Angiotensin II Approved, Investigational Phase 4,Phase 3 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
5
Regadenoson Approved, Investigational Phase 4 313348-27-5 219024
6
Nebivolol Approved, Investigational Phase 4 152520-56-4, 99200-09-6, 118457-14-0 71301
7
Adenosine Approved, Investigational Phase 4 58-61-7 60961
8
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
9
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
10
Exenatide Approved, Investigational Phase 4 141758-74-9 15991534
11 Estradiol valerate Approved, Investigational, Vet_approved Phase 4 979-32-8
12
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
13
Norethindrone Approved Phase 4 68-22-4 6230
14
Polyestradiol phosphate Approved Phase 4 28014-46-2
15
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 77-92-9 311
16 Atorvastatin Calcium Phase 4,Not Applicable 134523-03-8
17 Natriuretic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
18 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
19 Diuretics, Potassium Sparing Phase 4,Phase 3,Phase 2,Not Applicable
20 Vasodilator Agents Phase 4,Phase 3,Phase 2,Not Applicable
21 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4,Not Applicable
22 Hypolipidemic Agents Phase 4,Not Applicable
23 Phosphodiesterase 5 Inhibitors Phase 4,Phase 3,Phase 2
24 Phosphodiesterase Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
25 Anticholesteremic Agents Phase 4,Not Applicable
26 Lipid Regulating Agents Phase 4,Not Applicable
27 Antimetabolites Phase 4,Not Applicable
28 Calcium, Dietary Phase 4,Phase 2,Not Applicable
29 Sildenafil Citrate Phase 4,Phase 3,Phase 2 171599-83-0
30 diuretics Phase 4,Phase 3,Phase 2,Not Applicable
31 Mineralocorticoid Receptor Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
32 Mineralocorticoids Phase 4,Phase 3,Phase 2,Not Applicable
33 Adrenergic beta-Antagonists Phase 4,Not Applicable
34 Natriuretic Peptide, Brain Phase 4,Phase 1,Phase 2,Not Applicable
35 Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
36 Angiotensin II Type 1 Receptor Blockers Phase 4,Phase 3
37 Angiotensin Receptor Antagonists Phase 4,Phase 3
38 Angiotensinogen Phase 4,Phase 3
39 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
40 Peripheral Nervous System Agents Phase 4,Phase 1
41 Hypoglycemic Agents Phase 4,Not Applicable
42 Antihypertensive Agents Phase 4,Phase 3,Not Applicable
43 Protective Agents Phase 4,Phase 1,Not Applicable
44 Adrenergic Agents Phase 4
45 Adrenergic Agonists Phase 4
46 Adrenergic beta-Agonists Phase 4
47 Neurotransmitter Agents Phase 4
48 Sodium Potassium Chloride Symporter Inhibitors Phase 4
49 Dopamine Agents Phase 4
50 Autonomic Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 122)
# Name Status NCT ID Phase Drugs
1 Effects of Atorvastatin Treatment on Left Ventricular Diastolic Function in Peritoneal Dialysis Patients Unknown status NCT01503671 Phase 4 Atorvastatin
2 Novel Treatment for Diastolic Heart Failure in Women Completed NCT00206232 Phase 4 Spironolactone
3 Aldosterone Antagonism in Diastolic Heart Failure Completed NCT00108251 Phase 4 Eplerenone;Placebo
4 A Trial of Fimasartan for Early Diastolic Heart Failure Completed NCT01691118 Phase 4 Fimasartan;Antihypertensive treatment
5 Impacts of Aldosterone Blockade on Myocardial Remodeling in Hypertensive Patients With Diastolic Failing Heart Completed NCT01944384 Phase 4 aldactone
6 Efficacy and Safety of Valsartan Versus Placebo on Exercise Tolerance in Patients With Heart Failure Completed NCT00171106 Phase 4 valsartan
7 SIDAMI - Sildenafil and Diastolic Dysfunction After Acute Myocardial Infarction (AMI) Completed NCT01046838 Phase 4 Sildenafil;Placebo
8 Improving Treatment Personalization of Pulmonary Hypertension Associated With Diastolic Heart Failure Recruiting NCT02053246 Phase 4 Nebivolol
9 Myocardial Perfusion, Oxidative Metabolism, and Fibrosis in HFpEF Recruiting NCT02589977 Phase 4 regadenoson
10 Diuretics and Dopamine in Heart Failure With Preserved Ejection Fraction Active, not recruiting NCT01901809 Phase 4 Furosemide;Dopamine
11 Circulating NEP and NEP Inhibition Study in Heart Failure With Preserved Ejection Fraction Not yet recruiting NCT03506412 Phase 4 Entresto™ 49Mg-51 mg tablet
12 Reversing Endothelial and Diastolic Dysfunction and Improving Collagen Turnover in Diastolic Heart Failure Terminated NCT00293150 Phase 4 Eplerenone
13 Use of Nesiritide in the Management of Acute Diastolic Heart Failure Terminated NCT00083772 Phase 4 Nesiritide
14 Safety and Efficacy Trial to Treat Diastolic Heart Failure Using Ambrisentan Terminated NCT00840463 Phase 4 Ambrisentan
15 Evaluating the Use of Exenatide in People With Type 2 Diabetes and Diastolic Heart Failure Terminated NCT00799435 Phase 4 Exenatide
16 Estrogen Diastolic Heart Failure Terminated NCT02693002 Phase 4 Estradiol/Norethindrone acetate;Placebo
17 Denervation of the renAl sympathetIc nerveS in hearT Failure With nOrmal Lv Ejection Fraction Unknown status NCT01583881 Phase 2, Phase 3
18 A Randomized Trial of Udenafil Therapy in Patients With Heart Failure With Preserved Ejection Fraction [ULTIMATE-HFpEF] Unknown status NCT01599117 Phase 3 Placebo;Udenafil (Zydena)
19 Evaluating the Effectiveness of Sildenafil at Improving Health Outcomes and Exercise Ability in People With Diastolic Heart Failure (The RELAX Study) Completed NCT00763867 Phase 3 Placebo;Sildenafil
20 Phosphodiesterase-5 (PDE5) Inhibition and Pulmonary Hypertension in Diastolic Heart Failure Completed NCT01156636 Phase 2, Phase 3 Sildenafil;Placebo
21 Evaluation of Enalapril Versus Placebo in Patients With Diastolic Heart Failure Completed NCT01411735 Phase 3 Enalapril;placebo
22 PIE II: Pharmacological Intervention in the Elderly II Completed NCT00123955 Phase 3 Spironolactone;Placebo
23 Safety and Efficacy of Bosentan in Patients With Diastolic Heart Failure and Secondary Pulmonary Hypertension Completed NCT00820352 Phase 3 bosentan;placebo
24 Aldosterone Antagonist Therapy for Adults With Heart Failure and Preserved Systolic Function Completed NCT00094302 Phase 3 Spironolactone;Placebo
25 Sildenafil in HFpEF (Heart Failure With Preserved Ejection Fraction) and PH Completed NCT01726049 Phase 3 Sildenafil;Placebo
26 Novel Cardiac Rehabilitation in Patients Heart Failure and Preserved Ejection Fraction Recruiting NCT02762825 Phase 3
27 Optimized Management of Comorbidity in Heart Failure With Preserved Ejection Fraction in the Elderly (>60 Years) Recruiting NCT02425371 Phase 3
28 Efficacy and Safety of LCZ696 Compared to Valsartan, on Morbidity and Mortality in Heart Failure Patients With Preserved Ejection Fraction Active, not recruiting NCT01920711 Phase 3 LCZ696;Valsartan
29 Study of the Effect of Eplerenone on Heart Function in Women Receiving Anthracycline Chemotherapy for Breast Cancer Terminated NCT01708798 Phase 2, Phase 3 Eplerenone;Placebo
30 Study of Nesiritide in Diastolic Heart Failure. Completed NCT00309868 Phase 1, Phase 2 neseritide
31 A Study of the Effectiveness of Sitaxsentan Sodium in Patients With Diastolic Heart Failure Completed NCT00303498 Phase 2 Sitaxsentan sodium;Placebo
32 The DIAMOND Study: Distensibility Improvement And Remodeling in Diastolic Heart Failure Completed NCT00043836 Phase 2 ALT-711
33 Ranolazine in Diastolic Heart Failure Completed NCT01163734 Phase 2 Ranolazine
34 Perhexiline Therapy in Heart Failure With Preserved Ejection Fraction Syndrome Completed NCT00839228 Phase 2 Perhexiline;Placebo
35 Pharmacokinetics, Pharmacodynamics, and Impact of Inorganic Nitrate on Exercise in HFpEF Completed NCT02256345 Phase 2 KNO3;KCl
36 Natriuretic Peptide System as Therapy in Human Preclinical Left Ventricle Dysfunction Completed NCT00387621 Phase 1, Phase 2 Nesiritide;Placebo;Saline
37 Interleukin-1 Blockade in HF With Preserved EF Completed NCT02173548 Phase 2 Anakinra;Placebo
38 Radiofrequency-based Speckle Tracking Echocardiography to Evaluate Diastolic Function Completed NCT01182805 Phase 1, Phase 2
39 CoQ10 and D-ribose in Patients With Diastolic Heart Failure Recruiting NCT03133793 Phase 2 CoQ10;D-Ribose Oral Powder
40 Regression of Fibrosis & Reversal of Diastolic Dysfunction in HFPEF Patients Treated With Allogeneic CDCs Recruiting NCT02941705 Phase 2
41 Beginning a Randomized Evaluation of the AGE Breaker Alagebrium in Diastolic Heart Failure (BREAK-DHF-I) Terminated NCT00662116 Phase 2 alagebrium;placebo
42 A Randomized Double-Blind, Placebo-Controlled, Multiple-Dose Study to Evaluate the Effects of Alagebrium on Exercise in Subjects With Diastolic Heart Failure Terminated NCT01913301 Phase 2 Alagebrium
43 The Use of Ranolazine for Atrial Fibrillation and Diastolic Heart Failure Terminated NCT01887353 Phase 2 Ranolazine;Placebo
44 A Study to Test the Effects of Riociguat in Patients With Pulmonary Hypertension Associated With Left Ventricular Diastolic Dysfunction Terminated NCT01172756 Phase 2 Riociguat (BAY63-2521);Riociguat (BAY63-2521);Riociguat (BAY63-2521);Placebo
45 If Channel Blockade With Ivabradine in Patients With Diastolic Heart Failure Withdrawn NCT00757055 Phase 2 Ivabradine;Placebo
46 BNP Testing in Patients With SOB on Presentation to ED Unknown status NCT00163709 Phase 1
47 Physiological Effects of Grape Seed Extract in Diastolic Heart Failure Completed NCT01185067 Phase 1 grape seed extract (MegaNatural BP, Polyphenolics, Inc.)
48 Diastolic Heart Failure Management by Nifedipine Unknown status NCT01157481 Not Applicable Conventional therapy plus nifedipine;Conventional therapy
49 Effects of the Dietary Approaches to Stop Hypertension(DASH) Sodium-restricted Diet in Diastolic Heart Failure Unknown status NCT00939640 Not Applicable
50 LEft Atrial Pacing in Diastolic Heart Failure Unknown status NCT01618981 Not Applicable

Search NIH Clinical Center for Diastolic Heart Failure

Cochrane evidence based reviews: heart failure, diastolic

Genetic Tests for Diastolic Heart Failure

Anatomical Context for Diastolic Heart Failure

MalaCards organs/tissues related to Diastolic Heart Failure:

41
Heart, Testes, Brain, Endothelial, Kidney, Breast, Lung

Publications for Diastolic Heart Failure

Articles related to Diastolic Heart Failure:

(show top 50) (show all 460)
# Title Authors Year
1
Pulmonary Edema and Diastolic Heart Failure in the Perioperative Period. ( 29607222 )
2018
2
Impact of end stage renal disease on in-hospital outcomes of patients with systolic and diastolic heart failure (insights from the Nationwide Inpatient Sample 2010 to 2014). ( 29887443 )
2018
3
Etiologies, Trends, and Predictors of 30-Day Readmissions in Patients With Diastolic Heart Failure. ( 28648393 )
2017
4
Complexity of pathomechanisms leading to diastolic heart failure in diabetes mellitus - potential field for therapeutic interventions? ( 28934928 )
2017
5
Diastolic heart failure associated with hemangiosarcoma infiltrating left ventricular walls in a dog. ( 29089652 )
2017
6
Age-dependent diastolic heart failure in an in vivo Drosophila model. ( 28328397 )
2017
7
Endomyocardial Fibrosis: A Rare Case of Diastolic Heart Failure in a European Caucasian Elderly Woman. ( 28818409 )
2017
8
Stachydrine ameliorates pressure overload-induced diastolic heart failure by suppressing myocardial fibrosis. ( 28979698 )
2017
9
The role of Ivabradine in Diastolic Heart Failure with preserved Ejection Fraction. A Doppler-Echocardiographic study. ( 29142810 )
2017
10
Exercise training in Diastolic Heart Failure (Ex-DHF): rationale and design of a multicentre, prospective, randomized, controlled, parallel group trial. ( 28516519 )
2017
11
Shared biomarkers between female diastolic heart failure and pre-eclampsia: a systematic review and meta-analysis. ( 28451444 )
2017
12
Interleukin-1 blockade in heart failure with preserved ejection fraction: rationale and design of the Diastolic Heart Failure Anakinra Response Trial 2 (D-HART2). ( 28475816 )
2017
13
Shortness of breath in clinical practice: A case for left atrial function and exercise stress testing for a comprehensive diastolic heart failure workup. ( 29354484 )
2017
14
Deliberations on Diastolic Heart Failure. ( 28029360 )
2016
15
The Stiff Left Atrium Is to Atrial Fibrillation as the Stiff Left Ventricle Is to Diastolic Heart Failure. ( 26966289 )
2016
16
Diastolic Heart Failure Predicted by Left Atrial Expansion Index in Patients with Severe Diastolic Dysfunction. ( 27622475 )
2016
17
Association of ACE gene D polymorphism with left ventricular hypertrophy in patients with diastolic heart failure: a case-control study. ( 26861937 )
2016
18
Clinical effects of combined treatment by optimal dose of furosemide and spironolactone on diastolic heart failure in elderly patients. ( 26998008 )
2016
19
Impaired Right Ventricular-Pulmonary Arterial Coupling and Effect of Sildenafil in Heart Failure With Preserved Ejection Fraction: An Ancillary Analysis From the Phosphodiesterase-5 Inhibition to Improve Clinical Status And Exercise Capacity in Diastolic Heart Failure (RELAX) Trial. ( 27072860 )
2016
20
Diastolic heart failure: diagnosis and therapy. ( 26658178 )
2016
21
Pathophysiological role of oxidative stress in systolic and diastolic heart failure and its therapeutic implications. ( 26142467 )
2015
22
Complete heart block with diastolic heart failure and pulmonary edema secondary to enlarging previously diagnosed thrombosed aneurysm of sinus of valsalva in a patient with history of autosomal dominant polycystic kidney disease. ( 25861484 )
2015
23
Lowering body weight in obese mice with diastolic heart failure improves cardiac insulin sensitivity and function: implications for the obesity paradox. ( 25524917 )
2015
24
Constrictive pericarditis-a curable diastolic heart failure. ( 26440983 )
2015
25
Galectin-3 in heart failure with preserved ejection fraction. A RELAX trial substudy (Phosphodiesterase-5 Inhibition to Improve Clinical Status and Exercise Capacity in Diastolic Heart Failure). ( 25742762 )
2015
26
Increased Prevalence of Diastolic Heart Failure in Patients with Rheumatoid Arthritis Correlates with Active Disease, but Not with Treatment Type. ( 26373561 )
2015
27
Successful resection of a huge metastatic liposarcoma in the pericardium resulting in improvement of diastolic heart failure: a case report. ( 26366370 )
2015
28
The association and interaction analysis of hypertension and diabetes mellitus on diastolic heart failure in a high-risk population. ( 26885071 )
2015
29
Sustained Toll-Like Receptor 9 Activation Promotes Systemic and Cardiac Inflammation, and Aggravates Diastolic Heart Failure in SERCA2a KO Mice. ( 26461521 )
2015
30
Impact of the renin-angiotensin system and inflammatory gene polymorphisms on diastolic heart failure. ( 24530241 )
2014
31
Utility of lower limb positive pressure test for diagnosis of diastolic heart failure: a case report. ( 25264062 )
2014
32
Increased reactive oxygen species, metabolic maladaptation, and autophagy contribute to pulmonary arterial hypertension-induced ventricular hypertrophy and diastolic heart failure. ( 25267798 )
2014
33
Genetics of systolic and diastolic heart failure. ( 25380161 )
2014
34
Digoxin and 30-day All-cause Hospital Admission in Older Patients with Chronic Diastolic Heart Failure. ( 24067296 )
2014
35
Atorvastatin ameliorates cardiac fibrosis and improves left ventricular diastolic function in hypertensive diastolic heart failure model rats. ( 24759122 )
2014
36
Acute Hemodynamic Effects of Riociguat in Patients With Pulmonary Hypertension Associated With Diastolic Heart Failure (DILATE-1): A Randomized, Double-Blind, Placebo-Controlled, Single-Dose Study. ( 24991733 )
2014
37
Optimising exercise training in prevention and treatment of diastolic heart failure (OptimEx-CLIN): rationale and design of a prospective, randomised, controlled trial. ( 25354950 )
2014
38
CrossTalk opposing view: the late sodium current is not an important player in the development of diastolic heart failure (heart failure with a preserved ejection fraction). ( 24488067 )
2014
39
Myocardial energetics and ubiquinol in diastolic heart failure. ( 25263245 )
2014
40
Case 6/2014--A case of a 61-year-old woman with diastolic heart failure. ( 25590936 )
2014
41
CrossTalk proposal: The late sodium current is an important player in the development of diastolic heart failure (heart failure with a preserved ejection fraction). ( 24488066 )
2014
42
Heart failure with normal ejection fraction, heart failure with preserved ejection fraction, diastolic heart failure, or huff-puff: time for a new taxonomy for hypertensive-metabolic heart failure. ( 25151212 )
2014
43
Constrictive pericarditis--a curable diastolic heart failure. ( 25072910 )
2014
44
Connective tissue growth factor and cardiac diastolic dysfunction: human data from the Taiwan diastolic heart failure registry and molecular basis by cellular and animal models. ( 24464932 )
2014
45
New diagnostic and therapeutic possibilities for diastolic heart failure. ( 24494212 )
2014
46
Socioeconomic factors and mortality in diastolic heart failure. ( 24467732 )
2014
47
Association and predictive value analysis for metabolic syndrome on systolic and diastolic heart failure in high-risk patients. ( 25249273 )
2014
48
Tissue Doppler-derived E/e' ratio as a parameter for assessing diastolic heart failure and as a predictor of mortality in patients with chronic kidney disease. ( 23345995 )
2013
49
Diastolic heart failure: a confusing concept. ( 22961410 )
2013
50
Diastolic Heart Failure in Hypertension: Possible Preventive Benefits of Nebivolol Beyond Lowering Blood Pressure. ( 24371501 )
2013

Variations for Diastolic Heart Failure

Expression for Diastolic Heart Failure

Search GEO for disease gene expression data for Diastolic Heart Failure.

Pathways for Diastolic Heart Failure

GO Terms for Diastolic Heart Failure

Cellular components related to Diastolic Heart Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 ACE AGT CTGF MMP2 NPPB
2 sarcomere GO:0030017 8.62 MMP2 MYBPC3

Biological processes related to Diastolic Heart Failure according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.8 CTGF MMP2 NOS3
2 kidney development GO:0001822 9.72 ACE AGT AGTR1
3 regulation of lipid metabolic process GO:0019216 9.7 AGT ANKRD1 CTGF
4 regulation of cell growth GO:0001558 9.69 AGT AGTR1 CTGF
5 sarcomere organization GO:0045214 9.64 ANKRD1 MYBPC3
6 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.63 AGT MMP2
7 positive regulation of protein tyrosine kinase activity GO:0061098 9.62 ACE AGT
8 positive regulation of reactive oxygen species metabolic process GO:2000379 9.62 AGT AGTR1
9 positive regulation of blood vessel diameter GO:0097755 9.61 AGT NOS3
10 vasodilation GO:0042311 9.61 AGT NOS3
11 nitric oxide mediated signal transduction GO:0007263 9.6 AGT NOS3
12 positive regulation of cellular protein metabolic process GO:0032270 9.59 AGT AGTR1
13 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.58 AGT AGTR1
14 positive regulation of renal sodium excretion GO:0035815 9.58 AGT NPPB
15 low-density lipoprotein particle remodeling GO:0034374 9.57 AGT AGTR1
16 angiotensin maturation GO:0002003 9.56 ACE AGT
17 positive regulation of cholesterol esterification GO:0010873 9.54 AGT AGTR1
18 blood vessel remodeling GO:0001974 9.54 ACE AGT NOS3
19 regulation of vasoconstriction GO:0019229 9.5 ACE AGT AGTR1
20 positive regulation of NAD(P)H oxidase activity GO:0033864 9.49 AGT AGTR1
21 regulation of renal sodium excretion GO:0035813 9.48 AGT AGTR1
22 renin-angiotensin regulation of aldosterone production GO:0002018 9.46 AGT AGTR1
23 regulation of blood vessel diameter by renin-angiotensin GO:0002034 9.43 AGT AGTR1
24 regulation of blood vessel size GO:0050880 9.43 AGT NOS3 NPPB
25 regulation of renal output by angiotensin GO:0002019 9.4 ACE AGT
26 regulation of blood vessel diameter GO:0097746 9.33 ACE AGTR1 NPPB
27 regulation of blood pressure GO:0008217 9.26 ACE AGT NOS3 NPPB
28 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 8.8 ACE AGT AGTR1

Molecular functions related to Diastolic Heart Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 titin binding GO:0031432 8.96 ANKRD1 MYBPC3
2 bradykinin receptor binding GO:0031711 8.62 ACE AGTR1

Sources for Diastolic Heart Failure

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....